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PROS1 protein S (alpha) [Homo sapiens (human)]

Gene Symbol PROS1
Entrez Gene ID 5627
Full Name protein S (alpha)
Synonyms PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
General protein information
Preferred Names
vitamin K-dependent protein S
Names
vitamin K-dependent protein S
protein Sa
vitamin K-dependent plasma protein S
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q11.2

Summary This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]. lac of sum
Disorder MIM:

176880

Disorder Html: Thrombophilia due to protein S deficiency, 612336 (3)





The following PROS1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROS1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu38054 XM_005247626 PREDICTED: Homo sapiens protein S (alpha) (PROS1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price
OHu21617 NM_000313 Homo sapiens protein S (alpha) (PROS1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu38054
Accession Version XM_005247626.3
Sequence Information ORF Nucleotide Sequence (Length: 2127bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein S isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005612.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578807587. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTG TTTATATTTT AGAAATGATT TTATATACAA CCGTGCATGC
ATTTCTGTAT TGGTCGGCTT ATCTGGATGC AATTTTTTCT ATTCTATATG CTTTTTGTCA
AAGCAACAGG CTTCACAAGT CCTGGTTAGG AAGCGTCGTG CAAATTCTTT ACTTGAAGAA
ACCAAACAGG GTAATCTTGA AAGAGAATGC ATCGAAGAAC TGTGCAATAA AGAAGAAGCC
AGGGAGGTCT TTGAAAATGA CCCGGAAACG GATTATTTTT ATCCAAAATA CTTAGTTTGT
CTTCGCTCTT TTCAAACTGG GTTATTCACT GCTGCACGTC AGTCAACTAA TGCTTATCCT
GACCTAAGAA GCTGTGTCAA TGCCATTCCA GACCAGTGTA GTCCTCTGCC ATGCAATGAA
GATGGATATA TGAGCTGCAA AGATGGAAAA GCTTCTTTTA CTTGCACTTG TAAACCAGGT
TGGCAAGGAG AAAAGTGTGA ATTTGACATA AATGAATGCA AAGATCCCTC AAATATAAAT
GGAGGTTGCA GTCAAATTTG TGATAATACA CCTGGAAGTT ACCACTGTTC CTGTAAAAAT
GGTTTTGTTA TGCTTTCAAA TAAGAAAGAT TGTAAAGATG TGGATGAATG CTCTTTGAAG
CCAAGCATTT GTGGCACAGC TGTGTGCAAG AACATCCCAG GAGATTTTGA ATGTGAATGC
CCCGAAGGCT ACAGATATAA TCTCAAATCA AAGTCTTGTG AAGATATAGA TGAATGCTCT
GAGAACATGT GTGCTCAGCT TTGTGTCAAT TACCCTGGAG GTTACACTTG CTATTGTGAT
GGGAAGAAAG GATTCAAACT TGCCCAAGAT CAGAAGAGTT GTGAGGTTGT TTCAGTGTGC
CTTCCCTTGA ACCTTGACAC AAAGTATGAA TTACTTTACT TGGCGGAGCA GTTTGCAGGG
GTTGTTTTAT ATTTAAAATT TCGTTTGCCA GAAATCAGCA GATTTTCAGC AGAATTTGAT
TTCCGGACAT ATGATTCAGA AGGCGTGATA CTGTACGCAG AATCTATCGA TCACTCAGCG
TGGCTCCTGA TTGCACTTCG TGGTGGAAAG ATTGAAGTTC AGCTTAAGAA TGAACATACA
TCCAAAATCA CAACTGGAGG TGATGTTATT AATAATGGTC TATGGAATAT GGTGTCTGTG
GAAGAATTAG AACATAGTAT TAGCATTAAA ATAGCTAAAG AAGCTGTGAT GGATATAAAT
AAACCTGGAC CCCTTTTTAA GCCGGAAAAT GGATTGCTGG AAACCAAAGT ATACTTTGCA
GGATTCCCTC GGAAAGTGGA AAGTGAACTC ATTAAACCGA TTAACCCTCG TCTAGATGGA
TGTATACGAA GCTGGAATTT GATGAAGCAA GGAGCTTCTG GAATAAAGGA AATTATTCAA
GAAAAACAAA ATAAGCATTG CCTGGTTACT GTGGAGAAGG GCTCCTACTA TCCTGGTTCT
GGAATTGCTC AATTTCACAT AGATTATAAT AATGTATCCA GTGCTGAGGG TTGGCATGTA
AATGTGACCT TGAATATTCG TCCATCCACG GGCACTGGTG TTATGCTTGC CTTGGTTTCT
GGTAACAACA CAGTGCCCTT TGCTGTGTCC TTGGTGGACT CCACCTCTGA AAAATCACAG
GATATTCTGT TATCTGTTGA AAATACTGTA ATATATCGGA TACAGGCCCT AAGTCTATGT
TCCGATCAAC AATCTCATCT GGAATTTAGA GTCAACAGAA ACAATCTGGA GTTGTCGACA
CCACTTAAAA TAGAAACCAT CTCCCATGAA GACCTTCAAA GACAACTTGC CGTCTTGGAC
AAAGCAATGA AAGCAAAAGT GGCCACATAC CTGGGTGGCC TTCCAGATGT TCCATTCAGT
GCCACACCAG TGAATGCCTT TTATAATGGC TGCATGGAAG TGAATATTAA TGGTGTACAG
TTGGATCTGG ATGAAGCCAT TTCTAAACAT AATGATATTA GAGCTCACTC ATGTCCATCA
GTTTGGAAAA AGACAAAGAA TTCTTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005247683.1
CDS342..2468
Misc Feature(1)513..692(+)
Misc Feature(2)792..902(+)
Misc Feature(3)795..845(+)
Misc Feature(4)906..1007(+)
Misc Feature(5)906..968(+)
Misc Feature(6)1038..1163(+)
Misc Feature(7)1038..1094(+)
Misc Feature(8)1140..1280(+)
Misc Feature(9)1371..1802(+)
Misc Feature(10)1977..2378(+)
Translation
Position Chain Variation Link
33 33 c, t dbSNP:573869029
152 152 c, g dbSNP:149028936
153 153 c, g dbSNP:556161398
174 174 c, t dbSNP:199469484
202 202 a, c dbSNP:576574328
207 207 c, t dbSNP:750502941
217 217 a, c dbSNP:115932544
231 231 c, t dbSNP:767438604
240 240 a, g dbSNP:578237469
262 262 g, t dbSNP:560637972
280 280 g, t dbSNP:556711298
282 282 c, g dbSNP:368555701
293 293 a, c dbSNP:768787371
294 294 a, c dbSNP:775507528
299 299 a, g dbSNP:370938580
305 305 c, t dbSNP:769954380
311 311 c, g dbSNP:746249443
312 312 a, g dbSNP:781650662
320 320 c, t dbSNP:757542202
321 321 a, g dbSNP:752168816
325 325 a, c dbSNP:778142027
329 329 c, t dbSNP:757989356
330 330 a, g dbSNP:752200826
331 331 c, t dbSNP:765008272
333 333 a, c dbSNP:759298994
334 334 g, t dbSNP:535366972
346 346 a, g dbSNP:766252664
347 347 a, g dbSNP:566125037
350 350 c, g dbSNP:773204468
353 353 c, g dbSNP:771937532
354 354 a, g dbSNP:763043055
357 357 a, g dbSNP:775508221
364 364 -, g dbSNP:764581697
370 370 a, c dbSNP:769834423
373 373 c, t dbSNP:1130095
374 374 c, g dbSNP:372436056
375 375 c, g dbSNP:781259302
377 377 a, g dbSNP:769931178
382 382 -, gt dbSNP:761068042
382 382 a, g dbSNP:771394908
389 389 a, c, t dbSNP:559292587
395 395 g, t dbSNP:758928762
397 397 g, t dbSNP:752290481
402 402 a, c, g dbSNP:754518511
417 417 g, t dbSNP:753590699
439 439 a, t dbSNP:747426570
453 453 c, t dbSNP:750488882
460 460 a, g dbSNP:772538645
462 462 a, g dbSNP:767606472
476 476 c, t dbSNP:539094974
493 493 a, t dbSNP:577895925
499 499 -, t dbSNP:776147804
518 518 c, g dbSNP:200631087
519 519 c, t dbSNP:776526548
531 531 a, g dbSNP:192961830
541 541 c, t dbSNP:760850517
546 546 c, g dbSNP:773551347
555 555 c, t dbSNP:772628286
556 556 a, g, t dbSNP:7614835
558 558 c, t dbSNP:768994686
565 565 a, g dbSNP:748858986
571 571 -, t dbSNP:774537315
574 574 c, t dbSNP:779469907
585 585 a, g dbSNP:748630360
586 586 a, c dbSNP:745579260
589 589 -, ag dbSNP:199469485
590 590 a, g dbSNP:370320595
603 603 a, g dbSNP:377491237
604 604 a, g dbSNP:764911524
606 606 c, g dbSNP:757051970
607 607 a, t dbSNP:751299946
614 614 c, t dbSNP:764115962
615 615 a, g dbSNP:758232970
620 620 a, g dbSNP:536944947
626 626 c, t dbSNP:752653267
637 637 a, c dbSNP:766423432
644 644 a, g dbSNP:760800328
664 664 c, t dbSNP:73846070
665 665 a, g, t dbSNP:6121
670 670 c, t dbSNP:6122
671 671 a, g dbSNP:145399944
672 672 g, t dbSNP:776082764
673 673 a, t dbSNP:770400563
675 675 c, t dbSNP:145704559
686 686 a, g dbSNP:368834111
695 695 a, g dbSNP:139964194
696 696 c, g dbSNP:557733421
700 700 gtcttcgctc, ta dbSNP:199469486
705 705 c, t dbSNP:765935815
706 706 a, g dbSNP:200886866
712 712 g, t dbSNP:772748769
717 717 a, g dbSNP:200093789
721 721 a, g dbSNP:144526169
729 729 a, g dbSNP:747923334
730 730 c, g, t dbSNP:142805170
734 734 a, t dbSNP:768547718
736 736 a, c dbSNP:375363379
738 738 c, t dbSNP:778731080
747 747 a, g dbSNP:754897308
748 748 a, c dbSNP:753950548
751 751 a, g dbSNP:372589167
767 767 a, g dbSNP:201089893
775 775 g, t dbSNP:757418321
790 790 c, t dbSNP:761574063
801 801 a, t dbSNP:774133229
802 802 a, g dbSNP:768639397
823 823 a, g dbSNP:749024073
830 830 c, t dbSNP:775583347
835 835 a, g dbSNP:762130737
836 836 c, t dbSNP:769806365
856 856 a, c dbSNP:747091771
857 857 g, t dbSNP:200181798
867 867 a, c dbSNP:777950737
868 868 a, c dbSNP:146366248
875 875 a, c dbSNP:748464326
880 880 a, g dbSNP:779106655
885 885 a, c dbSNP:755346249
886 886 a, g dbSNP:754149240
889 889 g, t dbSNP:372605525
907 907 a, g dbSNP:751090951
908 908 c, t dbSNP:763878105
917 917 a, g dbSNP:75078530
923 923 a, g dbSNP:148015989
925 925 a, t dbSNP:765091559
933 933 a, c dbSNP:758625995
938 938 a, g dbSNP:776693071
940 940 a, g dbSNP:144430063
943 943 c, g dbSNP:761924988
963 963 c, g dbSNP:774449465
966 966 a, g dbSNP:138674918
973 973 c, g dbSNP:749528007
992 992 c, t dbSNP:780075199
994 994 a, g dbSNP:779391826
997 997 a, g dbSNP:755594059
1000 1000 -, a dbSNP:753544869
1000 1000 a, g dbSNP:146070827
1009 1009 a, t dbSNP:781747126
1013 1013 gctttcaa, tgaaagc dbSNP:199469487
1015 1015 c, t dbSNP:757807269
1016 1016 c, t dbSNP:752071797
1022 1022 c, t dbSNP:372109285
1023 1023 a, g dbSNP:121918474
1027 1027 a, g dbSNP:150360829
1031 1031 c, t dbSNP:752399066
1038 1038 a, g dbSNP:199469497
1050 1050 c, t dbSNP:755841990
1052 1052 c, t dbSNP:750429400
1064 1064 a, g dbSNP:767430849
1066 1066 c, g dbSNP:140490120
1069 1069 c, t dbSNP:557512030
1084 1084 c, t dbSNP:765320453
1099 1099 c, g, t dbSNP:1130097
1104 1104 g, t dbSNP:372919392
1113 1113 a, t dbSNP:370855515
1115 1115 c, t dbSNP:771424094
1121 1121 c, t dbSNP:377173471
1124 1124 c, g, t dbSNP:149129715
1125 1125 a, g dbSNP:575777099
1128 1128 a, g dbSNP:372735635
1132 1132 a, g dbSNP:754454487
1135 1135 -, t dbSNP:34250262
1135 1135 a, g dbSNP:41267007
1138 1138 a, g dbSNP:387906675
1140 1140 a, t dbSNP:779679020
1144 1144 g, t dbSNP:778562750
1146 1146 a, g dbSNP:750196720
1147 1147 a, c, g dbSNP:558211174
1151 1151 a, g dbSNP:751463817
1172 1172 c, t dbSNP:770695382
1175 1175 a, c dbSNP:139786558
1210 1210 a, g dbSNP:121918473
1224 1224 c, t dbSNP:1130098
1229 1229 c, t dbSNP:746804462
1231 1231 -, g dbSNP:774711924
1234 1234 a, g dbSNP:777616039
1251 1251 a, g dbSNP:41267005
1253 1253 a, t dbSNP:748053104
1256 1256 a, c dbSNP:780299397
1261 1261 c, t dbSNP:200839461
1264 1264 c, t dbSNP:756199160
1269 1269 a, g dbSNP:750744790
1272 1272 c, t dbSNP:121918475
1286 1286 c, g dbSNP:767767470
1288 1288 g, t dbSNP:751683365
1289 1289 g, t dbSNP:371425622
1292 1292 g, t dbSNP:758693569
1297 1297 c, t dbSNP:753269101
1301 1301 c, t dbSNP:554787241
1302 1302 c, t dbSNP:199469488
1317 1317 a, g dbSNP:368607471
1324 1324 a, t dbSNP:776171385
1329 1329 a, g dbSNP:765763193
1337 1337 c, t dbSNP:376814926
1340 1340 c, t dbSNP:760392622
1345 1345 c, t dbSNP:772677117
1346 1346 a, g, t dbSNP:537938359
1356 1356 g, t dbSNP:761691331
1357 1357 a, c dbSNP:774481269
1361 1361 g, t dbSNP:768686455
1365 1365 g, t dbSNP:749198162
1369 1369 c, t dbSNP:781355040
1383 1383 c, t dbSNP:373983977
1384 1384 a, g dbSNP:747259055
1387 1387 a, t dbSNP:777851115
1400 1400 c, t dbSNP:569018785
1408 1408 c, t dbSNP:780414556
1413 1413 c, g dbSNP:755702160
1417 1417 a, t dbSNP:746799331
1425 1425 c, t dbSNP:536077692
1426 1426 a, g dbSNP:549405539
1442 1442 a, g dbSNP:201547678
1445 1445 c, t dbSNP:141208672
1446 1446 a, g, t dbSNP:200771229
1452 1452 c, g dbSNP:775553965
1457 1457 c, t dbSNP:374634410
1458 1458 a, g dbSNP:189883848
1467 1467 a, t dbSNP:773309134
1469 1469 c, t dbSNP:78449232
1470 1470 a, g, t dbSNP:1130107
1478 1478 a, g dbSNP:376656035
1480 1480 c, t dbSNP:769125007
1481 1481 a, g dbSNP:375245889
1487 1487 c, t dbSNP:559926905
1493 1493 g, t dbSNP:199797185
1500 1500 c, t dbSNP:387906674
1501 1501 a, g dbSNP:780863931
1514 1514 a, t dbSNP:756759376
1531 1531 a, g dbSNP:751321863
1532 1532 g, t dbSNP:199469491
1535 1535 a, g dbSNP:758262158
1537 1537 a, t dbSNP:752399627
1540 1540 c, t dbSNP:765038390
1544 1544 c, t dbSNP:138227513
1581 1581 c, t dbSNP:776490592
1583 1583 -, at dbSNP:312262905
1590 1590 a, g dbSNP:767653920
1592 1592 g, t dbSNP:199469492
1616 1616 c, t dbSNP:373182289
1620 1620 a, g dbSNP:368987511
1623 1623 a, g dbSNP:761925121
1628 1628 c, t dbSNP:751672587
1632 1632 a, g dbSNP:764185248
1633 1633 c, t dbSNP:763099794
1642 1642 a, g dbSNP:775715647
1647 1647 a, g dbSNP:770121235
1652 1652 g, t dbSNP:201275494
1654 1654 a, t dbSNP:777326642
1658 1658 a, g dbSNP:771532496
1665 1665 a, c dbSNP:772372291
1666 1666 a, c dbSNP:199469495
1668 1668 c, g dbSNP:377398252
1679 1679 a, t dbSNP:771550308
1684 1684 a, c, t dbSNP:565325519
1685 1685 a, g dbSNP:148869673
1689 1689 a, t dbSNP:753603433
1698 1698 c, t dbSNP:779787688
1710 1710 a, g dbSNP:756068205
1718 1718 c, g, t dbSNP:764087288
1724 1724 a, t dbSNP:763086326
1725 1725 c, t dbSNP:374311589
1726 1726 c, t dbSNP:752918810
1728 1728 c, t dbSNP:765473908
1731 1731 c, t dbSNP:370129669
1741 1741 a, g dbSNP:777166983
1746 1746 -, gaaagtg dbSNP:773487150
1746 1746 a, g dbSNP:771370692
1759 1759 c, t dbSNP:375465427
1761 1761 a, g dbSNP:768097849
1768 1768 c, t dbSNP:369244777
1770 1770 c, t dbSNP:5017719
1771 1771 a, g dbSNP:375034896
1788 1788 c, t dbSNP:5017717
1789 1789 a, g dbSNP:571772261
1798 1798 a, g dbSNP:142464892
1807 1807 a, c dbSNP:781029829
1814 1814 a, g dbSNP:371312357
1830 1830 a, g, t dbSNP:199469496
1842 1842 a, g dbSNP:267599946
1843 1843 a, g dbSNP:779144609
1848 1848 a, c dbSNP:755038574
1856 1856 a, g dbSNP:367557409
1858 1858 a, t dbSNP:754177398
1861 1861 g, t dbSNP:766692725
1865 1865 a, g dbSNP:756478197
1871 1871 c, t dbSNP:199750003
1874 1874 -, gg dbSNP:199469499
1881 1881 a, g dbSNP:767728911
1883 1883 c, t dbSNP:535201753
1892 1892 a, t dbSNP:774654528
1895 1895 c, t dbSNP:763660645
1902 1902 a, g dbSNP:762438750
1913 1913 a, g dbSNP:372203184
1918 1918 a, g dbSNP:769404555
1920 1920 a, g dbSNP:745470312
1923 1923 -, gatta dbSNP:199469498
1923 1923 c, g dbSNP:776507863
1925 1925 a, t dbSNP:770570577
1931 1931 c, t dbSNP:76877671
1938 1938 c, g, t dbSNP:121918472
1940 1940 c, t dbSNP:752234716
1942 1942 a, g dbSNP:764602594
1949 1949 g, t dbSNP:759240142
1950 1950 a, g dbSNP:185502739
1958 1958 c, g, t dbSNP:760371116
1960 1960 c, t dbSNP:773328733
1965 1965 a, c, g dbSNP:138925964
1973 1973 a, g dbSNP:780297724
1980 1980 c, t dbSNP:199469500
1981 1981 a, g dbSNP:769700380
1982 1982 c, t dbSNP:779137762
1990 1990 c, t dbSNP:373336653
1991 1991 a, g dbSNP:754209314
1994 1994 c, g dbSNP:757691694
1995 1995 a, c dbSNP:751888892
2001 2001 a, c, g dbSNP:758927346
2003 2003 a, t dbSNP:753144615
2016 2016 c, g dbSNP:143448451
2026 2026 a, t dbSNP:764804836
2030 2030 c, t dbSNP:758960496
2031 2031 a, g, t dbSNP:371028997
2033 2033 a, g dbSNP:55897523
2063 2063 c, t dbSNP:760366435
2066 2066 c, t dbSNP:773166529
2081 2081 g, t dbSNP:532641819
2088 2088 c, g dbSNP:762910577
2091 2091 c, t dbSNP:776594061
2093 2093 a, g dbSNP:770939909
2112 2112 a, g dbSNP:747235908
2114 2114 a, g dbSNP:184798444
2117 2117 a, g, t dbSNP:199469503
2118 2118 c, g, t dbSNP:121918476
2119 2119 a, g dbSNP:377174703
2144 2144 c, t dbSNP:566166669
2145 2145 a, g, t dbSNP:755684845
2150 2150 a, g dbSNP:571916140
2153 2153 a, g dbSNP:767257726
2154 2154 c, t dbSNP:202089574
2155 2155 a, c dbSNP:751343895
2163 2163 a, g dbSNP:763898193
2164 2164 a, t dbSNP:528604865
2174 2174 c, t dbSNP:775431133
2179 2179 a, g dbSNP:766513087
2182 2182 -, a dbSNP:771849864
2184 2184 a, c dbSNP:139479630
2187 2187 a, c dbSNP:773471178
2189 2189 a, g dbSNP:772250170
2190 2190 c, g dbSNP:748359980
2195 2195 c, g dbSNP:774595077
2197 2197 c, t dbSNP:200228050
2198 2198 a, c, g, t dbSNP:148234743
2199 2199 a, g dbSNP:142846443
2227 2227 a, c dbSNP:780812527
2232 2232 c, g dbSNP:193013939
2244 2244 c, g dbSNP:751163405
2247 2247 c, t dbSNP:777431045
2252 2252 c, t dbSNP:758204799
2253 2253 a, g dbSNP:371885410
2254 2254 c, t dbSNP:765135930
2258 2258 a, g dbSNP:760782629
2269 2269 c, t dbSNP:750531364
2275 2275 c, g dbSNP:767529331
2277 2277 a, g dbSNP:761946767
2280 2280 a, g dbSNP:368612500
2283 2283 a, g dbSNP:768960007
2284 2284 c, t dbSNP:145711536
2288 2288 a, g dbSNP:372298532
2301 2301 a, c dbSNP:770459080
2303 2303 c, t dbSNP:746331652
2326 2326 c, t dbSNP:202190731
2336 2336 c, t dbSNP:761940023
2339 2339 c, t dbSNP:751777823
2344 2344 a, g dbSNP:368173480
2357 2357 a, g dbSNP:764350708
2365 2365 a, t dbSNP:140472966
2373 2373 a, g dbSNP:776022988
2374 2374 a, g dbSNP:555902969
2376 2376 a, g dbSNP:760123082
2382 2382 c, t dbSNP:777271187
2385 2385 g, t dbSNP:770401147
2387 2387 c, t dbSNP:746506055
2388 2388 c, g dbSNP:772779235
2415 2415 a, g dbSNP:375706546
2417 2417 c, t dbSNP:771787159
2418 2418 a, g dbSNP:141122478
2427 2427 c, t dbSNP:147324335
2431 2431 c, t dbSNP:778685576
2438 2438 a, g dbSNP:6123
2445 2445 a, t dbSNP:749281590
2448 2448 a, c dbSNP:780019458
2454 2454 a, c dbSNP:757325057
2457 2457 a, g dbSNP:751695331
2459 2459 g, t dbSNP:764034062
2468 2468 a, g, t dbSNP:267606981
2473 2473 c, t dbSNP:752897750
2474 2474 c, t dbSNP:539986049
2479 2479 a, c dbSNP:556217785
2483 2483 c, g dbSNP:777322625
2485 2485 c, t dbSNP:766878244
2486 2486 g, t dbSNP:761046948
2489 2489 a, g dbSNP:772800528
2493 2493 a, c dbSNP:771423259
2498 2498 g, t dbSNP:747865234
2500 2500 a, c dbSNP:199820528
2502 2502 a, t dbSNP:773981911
2505 2505 a, g dbSNP:772879763
2513 2513 a, g dbSNP:768490238
2514 2514 -, ta dbSNP:778661381
2514 2514 c, t dbSNP:539591634
2553 2553 a, g dbSNP:570472005
2564 2564 c, t dbSNP:553753206
2623 2623 a, t dbSNP:534064879
2663 2663 a, c dbSNP:555142434
2665 2665 c, t dbSNP:182088150
2686 2686 a, c dbSNP:548497101
2689 2689 -, a dbSNP:776969264
2755 2755 a, g dbSNP:531381061
2769 2769 a, c dbSNP:569117154
2790 2790 a, g dbSNP:768432447
2837 2837 c, t dbSNP:535034037
2838 2838 a, g dbSNP:144135580
2848 2848 a, g, t dbSNP:138546241
2890 2890 c, g dbSNP:770100925
2922 2922 a, g dbSNP:539871594
2937 2937 a, c dbSNP:147496684
2972 2972 c, t dbSNP:562230741
2984 2984 g, t dbSNP:542539134
2988 2988 a, c dbSNP:9681204
2998 2998 c, t dbSNP:556348407
3087 3087 c, g dbSNP:746059789
3091 3091 a, c dbSNP:781732448
3098 3098 g, t dbSNP:545846439
3154 3154 a, g dbSNP:550909963
3161 3161 a, g dbSNP:189450409
3168 3168 c, g dbSNP:778445562
3205 3205 c, g dbSNP:538937681
3210 3210 c, t dbSNP:374824636
3222 3222 a, c dbSNP:60153116
3247 3247 g, t dbSNP:112945093
3251 3251 c, t dbSNP:137965257
3301 3301 a, g dbSNP:574802526
3302 3302 c, t dbSNP:757503126
3399 3399 c, t dbSNP:554561641
3400 3400 a, g dbSNP:558951098
3440 3440 c, t dbSNP:538178021
3441 3441 g, t dbSNP:569034825
3444 3444 c, t dbSNP:552407111
3460 3460 g, t dbSNP:538711279
3485 3485 c, t dbSNP:566589234
3514 3514 c, t dbSNP:546710591
3544 3544 c, t dbSNP:753438503
3571 3571 a, g dbSNP:779418455
3573 3573 c, t dbSNP:186560028
3587 3587 c, t dbSNP:556433008
3588 3588 a, g dbSNP:548591822
3638 3638 a, g dbSNP:140073790
3659 3659 a, t dbSNP:562714994

Target ORF information:

RefSeq Version XM_005247626
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein S (alpha) (PROS1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005247626

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTG TTTATATTTT AGAAATGATT TTATATACAA CCGTGCATGC
ATTTCTGTAT TGGTCGGCTT ATCTGGATGC AATTTTTTCT ATTCTATATG CTTTTTGTCA
AAGCAACAGG CTTCACAAGT CCTGGTTAGG AAGCGTCGTG CAAATTCTTT ACTTGAAGAA
ACCAAACAGG GTAATCTTGA AAGAGAATGC ATCGAAGAAC TGTGCAATAA AGAAGAAGCC
AGGGAGGTCT TTGAAAATGA CCCGGAAACG GATTATTTTT ATCCAAAATA CTTAGTTTGT
CTTCGCTCTT TTCAAACTGG GTTATTCACT GCTGCACGTC AGTCAACTAA TGCTTATCCT
GACCTAAGAA GCTGTGTCAA TGCCATTCCA GACCAGTGTA GTCCTCTGCC ATGCAATGAA
GATGGATATA TGAGCTGCAA AGATGGAAAA GCTTCTTTTA CTTGCACTTG TAAACCAGGT
TGGCAAGGAG AAAAGTGTGA ATTTGACATA AATGAATGCA AAGATCCCTC AAATATAAAT
GGAGGTTGCA GTCAAATTTG TGATAATACA CCTGGAAGTT ACCACTGTTC CTGTAAAAAT
GGTTTTGTTA TGCTTTCAAA TAAGAAAGAT TGTAAAGATG TGGATGAATG CTCTTTGAAG
CCAAGCATTT GTGGCACAGC TGTGTGCAAG AACATCCCAG GAGATTTTGA ATGTGAATGC
CCCGAAGGCT ACAGATATAA TCTCAAATCA AAGTCTTGTG AAGATATAGA TGAATGCTCT
GAGAACATGT GTGCTCAGCT TTGTGTCAAT TACCCTGGAG GTTACACTTG CTATTGTGAT
GGGAAGAAAG GATTCAAACT TGCCCAAGAT CAGAAGAGTT GTGAGGTTGT TTCAGTGTGC
CTTCCCTTGA ACCTTGACAC AAAGTATGAA TTACTTTACT TGGCGGAGCA GTTTGCAGGG
GTTGTTTTAT ATTTAAAATT TCGTTTGCCA GAAATCAGCA GATTTTCAGC AGAATTTGAT
TTCCGGACAT ATGATTCAGA AGGCGTGATA CTGTACGCAG AATCTATCGA TCACTCAGCG
TGGCTCCTGA TTGCACTTCG TGGTGGAAAG ATTGAAGTTC AGCTTAAGAA TGAACATACA
TCCAAAATCA CAACTGGAGG TGATGTTATT AATAATGGTC TATGGAATAT GGTGTCTGTG
GAAGAATTAG AACATAGTAT TAGCATTAAA ATAGCTAAAG AAGCTGTGAT GGATATAAAT
AAACCTGGAC CCCTTTTTAA GCCGGAAAAT GGATTGCTGG AAACCAAAGT ATACTTTGCA
GGATTCCCTC GGAAAGTGGA AAGTGAACTC ATTAAACCGA TTAACCCTCG TCTAGATGGA
TGTATACGAA GCTGGAATTT GATGAAGCAA GGAGCTTCTG GAATAAAGGA AATTATTCAA
GAAAAACAAA ATAAGCATTG CCTGGTTACT GTGGAGAAGG GCTCCTACTA TCCTGGTTCT
GGAATTGCTC AATTTCACAT AGATTATAAT AATGTATCCA GTGCTGAGGG TTGGCATGTA
AATGTGACCT TGAATATTCG TCCATCCACG GGCACTGGTG TTATGCTTGC CTTGGTTTCT
GGTAACAACA CAGTGCCCTT TGCTGTGTCC TTGGTGGACT CCACCTCTGA AAAATCACAG
GATATTCTGT TATCTGTTGA AAATACTGTA ATATATCGGA TACAGGCCCT AAGTCTATGT
TCCGATCAAC AATCTCATCT GGAATTTAGA GTCAACAGAA ACAATCTGGA GTTGTCGACA
CCACTTAAAA TAGAAACCAT CTCCCATGAA GACCTTCAAA GACAACTTGC CGTCTTGGAC
AAAGCAATGA AAGCAAAAGT GGCCACATAC CTGGGTGGCC TTCCAGATGT TCCATTCAGT
GCCACACCAG TGAATGCCTT TTATAATGGC TGCATGGAAG TGAATATTAA TGGTGTACAG
TTGGATCTGG ATGAAGCCAT TTCTAAACAT AATGATATTA GAGCTCACTC ATGTCCATCA
GTTTGGAAAA AGACAAAGAA TTCTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21617
Accession Version NM_000313.3
Sequence Information ORF Nucleotide Sequence (Length: 2031bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein S preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB275740.1, BC015801.1, AC144562.5 and AI139337.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2009 this sequence version replaced gi:192447437. Summary: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y00692.1, M15036.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000304.2
CDS342..2372
Misc Feature(1)90..92(+)
Misc Feature(2)408..596(+)
Misc Feature(3)480..482(+)
Misc Feature(4)483..485(+)
Misc Feature(5)504..506(+)
Misc Feature(6)510..512(+)
Misc Feature(7)519..521(+)
Misc Feature(8)522..524(+)
Misc Feature(9)537..539(+)
Misc Feature(10)540..542(+)
Misc Feature(11)549..551(+)
Misc Feature(12)558..560(+)
Misc Feature(13)570..572(+)
Misc Feature(14)603..689(+)
Misc Feature(15)696..806(+)
Misc Feature(16)699..749(+)
Misc Feature(17)810..911(+)
Misc Feature(18)810..872(+)
Misc Feature(19)942..1067(+)
Misc Feature(20)942..998(+)
Misc Feature(21)1080..1187(+)
Misc Feature(22)1275..1706(+)
Misc Feature(23)1836..1838(+)
Misc Feature(24)1881..2282(+)
Exon (1)1..417
Gene:PROS1
Gene Synonym:
Exon (2)418..575
Gene:PROS1
Gene Synonym:
Exon (3)576..600
Gene:PROS1
Gene Synonym:
Exon (4)601..687
Gene:PROS1
Gene Synonym:
Exon (5)688..810
Gene:PROS1
Gene Synonym:
Exon (6)811..942
Gene:PROS1
Gene Synonym:
Exon (7)943..1068
Gene:PROS1
Gene Synonym:
Exon (8)1069..1190
Gene:PROS1
Gene Synonym:
Exon (9)1191..1306
Gene:PROS1
Gene Synonym:
Exon (10)1307..1496
Gene:PROS1
Gene Synonym:
Exon (11)1497..1664
Gene:PROS1
Gene Synonym:
Exon (12)1665..1833
Gene:PROS1
Gene Synonym:
Exon (13)1834..1985
Gene:PROS1
Gene Synonym:
Exon (14)1986..2211
Gene:PROS1
Gene Synonym:
Exon (15)2212..3580
Gene:PROS1
Gene Synonym:
Translation
Position Chain Variation Link
33 33 c, t dbSNP:573869029
152 152 c, g dbSNP:149028936
153 153 c, g dbSNP:556161398
174 174 c, t dbSNP:199469484
202 202 a, c dbSNP:576574328
207 207 c, t dbSNP:750502941
217 217 a, c dbSNP:115932544
231 231 c, t dbSNP:767438604
240 240 a, g dbSNP:578237469
262 262 g, t dbSNP:560637972
280 280 g, t dbSNP:556711298
282 282 c, g dbSNP:368555701
293 293 a, c dbSNP:768787371
294 294 a, c dbSNP:775507528
299 299 a, g dbSNP:370938580
305 305 c, t dbSNP:769954380
311 311 c, g dbSNP:746249443
312 312 a, g dbSNP:781650662
320 320 c, t dbSNP:757542202
321 321 a, g dbSNP:752168816
325 325 a, c dbSNP:778142027
329 329 c, t dbSNP:757989356
330 330 a, g dbSNP:752200826
331 331 c, t dbSNP:765008272
333 333 a, c dbSNP:759298994
334 334 g, t dbSNP:535366972
346 346 a, g dbSNP:766252664
347 347 a, g dbSNP:566125037
350 350 c, g dbSNP:773204468
353 353 c, g dbSNP:771937532
354 354 a, g dbSNP:763043055
357 357 a, g dbSNP:775508221
364 364 -, g dbSNP:764581697
370 370 a, c dbSNP:769834423
373 373 c, t dbSNP:1130095
374 374 c, g dbSNP:372436056
375 375 c, g dbSNP:781259302
377 377 a, g dbSNP:769931178
382 382 -, gt dbSNP:761068042
382 382 a, g dbSNP:771394908
389 389 a, c, t dbSNP:559292587
395 395 g, t dbSNP:758928762
397 397 g, t dbSNP:752290481
402 402 a, c, g dbSNP:754518511
417 417 g, t dbSNP:753590699
422 422 c, g dbSNP:200631087
423 423 c, t dbSNP:776526548
435 435 a, g dbSNP:192961830
445 445 c, t dbSNP:760850517
450 450 c, g dbSNP:773551347
459 459 c, t dbSNP:772628286
460 460 a, g, t dbSNP:7614835
462 462 c, t dbSNP:768994686
469 469 a, g dbSNP:748858986
475 475 -, t dbSNP:774537315
478 478 c, t dbSNP:779469907
489 489 a, g dbSNP:748630360
490 490 a, c dbSNP:745579260
493 493 -, ag dbSNP:199469485
494 494 a, g dbSNP:370320595
507 507 a, g dbSNP:377491237
508 508 a, g dbSNP:764911524
510 510 c, g dbSNP:757051970
511 511 a, t dbSNP:751299946
518 518 c, t dbSNP:764115962
519 519 a, g dbSNP:758232970
524 524 a, g dbSNP:536944947
530 530 c, t dbSNP:752653267
541 541 a, c dbSNP:766423432
548 548 a, g dbSNP:760800328
568 568 c, t dbSNP:73846070
569 569 a, g, t dbSNP:6121
574 574 c, t dbSNP:6122
575 575 a, g dbSNP:145399944
576 576 g, t dbSNP:776082764
577 577 a, t dbSNP:770400563
579 579 c, t dbSNP:145704559
590 590 a, g dbSNP:368834111
599 599 a, g dbSNP:139964194
600 600 c, g dbSNP:557733421
604 604 gtcttcgctc, ta dbSNP:199469486
609 609 c, t dbSNP:765935815
610 610 a, g dbSNP:200886866
616 616 g, t dbSNP:772748769
621 621 a, g dbSNP:200093789
625 625 a, g dbSNP:144526169
633 633 a, g dbSNP:747923334
634 634 c, g, t dbSNP:142805170
638 638 a, t dbSNP:768547718
640 640 a, c dbSNP:375363379
642 642 c, t dbSNP:778731080
651 651 a, g dbSNP:754897308
652 652 a, c dbSNP:753950548
655 655 a, g dbSNP:372589167
671 671 a, g dbSNP:201089893
679 679 g, t dbSNP:757418321
694 694 c, t dbSNP:761574063
705 705 a, t dbSNP:774133229
706 706 a, g dbSNP:768639397
727 727 a, g dbSNP:749024073
734 734 c, t dbSNP:775583347
739 739 a, g dbSNP:762130737
740 740 c, t dbSNP:769806365
760 760 a, c dbSNP:747091771
761 761 g, t dbSNP:200181798
771 771 a, c dbSNP:777950737
772 772 a, c dbSNP:146366248
779 779 a, c dbSNP:748464326
784 784 a, g dbSNP:779106655
789 789 a, c dbSNP:755346249
790 790 a, g dbSNP:754149240
793 793 g, t dbSNP:372605525
811 811 a, g dbSNP:751090951
812 812 c, t dbSNP:763878105
821 821 a, g dbSNP:75078530
827 827 a, g dbSNP:148015989
829 829 a, t dbSNP:765091559
837 837 a, c dbSNP:758625995
842 842 a, g dbSNP:776693071
844 844 a, g dbSNP:144430063
847 847 c, g dbSNP:761924988
867 867 c, g dbSNP:774449465
870 870 a, g dbSNP:138674918
877 877 c, g dbSNP:749528007
896 896 c, t dbSNP:780075199
898 898 a, g dbSNP:779391826
901 901 a, g dbSNP:755594059
904 904 -, a dbSNP:753544869
904 904 a, g dbSNP:146070827
913 913 a, t dbSNP:781747126
917 917 gctttcaa, tgaaagc dbSNP:199469487
919 919 c, t dbSNP:757807269
920 920 c, t dbSNP:752071797
926 926 c, t dbSNP:372109285
927 927 a, g dbSNP:121918474
931 931 a, g dbSNP:150360829
935 935 c, t dbSNP:752399066
942 942 a, g dbSNP:199469497
954 954 c, t dbSNP:755841990
956 956 c, t dbSNP:750429400
968 968 a, g dbSNP:767430849
970 970 c, g dbSNP:140490120
973 973 c, t dbSNP:557512030
988 988 c, t dbSNP:765320453
1003 1003 c, g, t dbSNP:1130097
1008 1008 g, t dbSNP:372919392
1017 1017 a, t dbSNP:370855515
1019 1019 c, t dbSNP:771424094
1025 1025 c, t dbSNP:377173471
1028 1028 c, g, t dbSNP:149129715
1029 1029 a, g dbSNP:575777099
1032 1032 a, g dbSNP:372735635
1036 1036 a, g dbSNP:754454487
1039 1039 -, t dbSNP:34250262
1039 1039 a, g dbSNP:41267007
1042 1042 a, g dbSNP:387906675
1044 1044 a, t dbSNP:779679020
1048 1048 g, t dbSNP:778562750
1050 1050 a, g dbSNP:750196720
1051 1051 a, c, g dbSNP:558211174
1055 1055 a, g dbSNP:751463817
1076 1076 c, t dbSNP:770695382
1079 1079 a, c dbSNP:139786558
1114 1114 a, g dbSNP:121918473
1128 1128 c, t dbSNP:1130098
1133 1133 c, t dbSNP:746804462
1135 1135 -, g dbSNP:774711924
1138 1138 a, g dbSNP:777616039
1155 1155 a, g dbSNP:41267005
1157 1157 a, t dbSNP:748053104
1160 1160 a, c dbSNP:780299397
1165 1165 c, t dbSNP:200839461
1168 1168 c, t dbSNP:756199160
1173 1173 a, g dbSNP:750744790
1176 1176 c, t dbSNP:121918475
1190 1190 c, g dbSNP:767767470
1192 1192 g, t dbSNP:751683365
1193 1193 g, t dbSNP:371425622
1196 1196 g, t dbSNP:758693569
1201 1201 c, t dbSNP:753269101
1205 1205 c, t dbSNP:554787241
1206 1206 c, t dbSNP:199469488
1221 1221 a, g dbSNP:368607471
1228 1228 a, t dbSNP:776171385
1233 1233 a, g dbSNP:765763193
1241 1241 c, t dbSNP:376814926
1244 1244 c, t dbSNP:760392622
1249 1249 c, t dbSNP:772677117
1250 1250 a, g, t dbSNP:537938359
1260 1260 g, t dbSNP:761691331
1261 1261 a, c dbSNP:774481269
1265 1265 g, t dbSNP:768686455
1269 1269 g, t dbSNP:749198162
1273 1273 c, t dbSNP:781355040
1287 1287 c, t dbSNP:373983977
1288 1288 a, g dbSNP:747259055
1291 1291 a, t dbSNP:777851115
1304 1304 c, t dbSNP:569018785
1312 1312 c, t dbSNP:780414556
1317 1317 c, g dbSNP:755702160
1321 1321 a, t dbSNP:746799331
1329 1329 c, t dbSNP:536077692
1330 1330 a, g dbSNP:549405539
1346 1346 a, g dbSNP:201547678
1349 1349 c, t dbSNP:141208672
1350 1350 a, g, t dbSNP:200771229
1356 1356 c, g dbSNP:775553965
1361 1361 c, t dbSNP:374634410
1362 1362 a, g dbSNP:189883848
1371 1371 a, t dbSNP:773309134
1373 1373 c, t dbSNP:78449232
1374 1374 a, g, t dbSNP:1130107
1382 1382 a, g dbSNP:376656035
1384 1384 c, t dbSNP:769125007
1385 1385 a, g dbSNP:375245889
1391 1391 c, t dbSNP:559926905
1397 1397 g, t dbSNP:199797185
1404 1404 c, t dbSNP:387906674
1405 1405 a, g dbSNP:780863931
1418 1418 a, t dbSNP:756759376
1435 1435 a, g dbSNP:751321863
1436 1436 g, t dbSNP:199469491
1439 1439 a, g dbSNP:758262158
1441 1441 a, t dbSNP:752399627
1444 1444 c, t dbSNP:765038390
1448 1448 c, t dbSNP:138227513
1485 1485 c, t dbSNP:776490592
1487 1487 -, at dbSNP:312262905
1494 1494 a, g dbSNP:767653920
1496 1496 g, t dbSNP:199469492
1520 1520 c, t dbSNP:373182289
1524 1524 a, g dbSNP:368987511
1527 1527 a, g dbSNP:761925121
1532 1532 c, t dbSNP:751672587
1536 1536 a, g dbSNP:764185248
1537 1537 c, t dbSNP:763099794
1546 1546 a, g dbSNP:775715647
1551 1551 a, g dbSNP:770121235
1556 1556 g, t dbSNP:201275494
1558 1558 a, t dbSNP:777326642
1562 1562 a, g dbSNP:771532496
1569 1569 a, c dbSNP:772372291
1570 1570 a, c dbSNP:199469495
1572 1572 c, g dbSNP:377398252
1583 1583 a, t dbSNP:771550308
1588 1588 a, c, t dbSNP:565325519
1589 1589 a, g dbSNP:148869673
1593 1593 a, t dbSNP:753603433
1602 1602 c, t dbSNP:779787688
1614 1614 a, g dbSNP:756068205
1622 1622 c, g, t dbSNP:764087288
1628 1628 a, t dbSNP:763086326
1629 1629 c, t dbSNP:374311589
1630 1630 c, t dbSNP:752918810
1632 1632 c, t dbSNP:765473908
1635 1635 c, t dbSNP:370129669
1645 1645 a, g dbSNP:777166983
1650 1650 -, gaaagtg dbSNP:773487150
1650 1650 a, g dbSNP:771370692
1663 1663 c, t dbSNP:375465427
1665 1665 a, g dbSNP:768097849
1672 1672 c, t dbSNP:369244777
1674 1674 c, t dbSNP:5017719
1675 1675 a, g dbSNP:375034896
1692 1692 c, t dbSNP:5017717
1693 1693 a, g dbSNP:571772261
1702 1702 a, g dbSNP:142464892
1711 1711 a, c dbSNP:781029829
1718 1718 a, g dbSNP:371312357
1734 1734 a, g, t dbSNP:199469496
1746 1746 a, g dbSNP:267599946
1747 1747 a, g dbSNP:779144609
1752 1752 a, c dbSNP:755038574
1760 1760 a, g dbSNP:367557409
1762 1762 a, t dbSNP:754177398
1765 1765 g, t dbSNP:766692725
1769 1769 a, g dbSNP:756478197
1775 1775 c, t dbSNP:199750003
1778 1778 -, gg dbSNP:199469499
1785 1785 a, g dbSNP:767728911
1787 1787 c, t dbSNP:535201753
1796 1796 a, t dbSNP:774654528
1799 1799 c, t dbSNP:763660645
1806 1806 a, g dbSNP:762438750
1817 1817 a, g dbSNP:372203184
1822 1822 a, g dbSNP:769404555
1824 1824 a, g dbSNP:745470312
1827 1827 -, gatta dbSNP:199469498
1827 1827 c, g dbSNP:776507863
1829 1829 a, t dbSNP:770570577
1835 1835 c, t dbSNP:76877671
1842 1842 c, g, t dbSNP:121918472
1844 1844 c, t dbSNP:752234716
1846 1846 a, g dbSNP:764602594
1853 1853 g, t dbSNP:759240142
1854 1854 a, g dbSNP:185502739
1862 1862 c, g, t dbSNP:760371116
1864 1864 c, t dbSNP:773328733
1869 1869 a, c, g dbSNP:138925964
1877 1877 a, g dbSNP:780297724
1884 1884 c, t dbSNP:199469500
1885 1885 a, g dbSNP:769700380
1886 1886 c, t dbSNP:779137762
1894 1894 c, t dbSNP:373336653
1895 1895 a, g dbSNP:754209314
1898 1898 c, g dbSNP:757691694
1899 1899 a, c dbSNP:751888892
1905 1905 a, c, g dbSNP:758927346
1907 1907 a, t dbSNP:753144615
1920 1920 c, g dbSNP:143448451
1930 1930 a, t dbSNP:764804836
1934 1934 c, t dbSNP:758960496
1935 1935 a, g, t dbSNP:371028997
1937 1937 a, g dbSNP:55897523
1967 1967 c, t dbSNP:760366435
1970 1970 c, t dbSNP:773166529
1985 1985 g, t dbSNP:532641819
1992 1992 c, g dbSNP:762910577
1995 1995 c, t dbSNP:776594061
1997 1997 a, g dbSNP:770939909
2016 2016 a, g dbSNP:747235908
2018 2018 a, g dbSNP:184798444
2021 2021 a, g, t dbSNP:199469503
2022 2022 c, g, t dbSNP:121918476
2023 2023 a, g dbSNP:377174703
2048 2048 c, t dbSNP:566166669
2049 2049 a, g, t dbSNP:755684845
2054 2054 a, g dbSNP:571916140
2057 2057 a, g dbSNP:767257726
2058 2058 c, t dbSNP:202089574
2059 2059 a, c dbSNP:751343895
2067 2067 a, g dbSNP:763898193
2068 2068 a, t dbSNP:528604865
2078 2078 c, t dbSNP:775431133
2083 2083 a, g dbSNP:766513087
2086 2086 -, a dbSNP:771849864
2088 2088 a, c dbSNP:139479630
2091 2091 a, c dbSNP:773471178
2093 2093 a, g dbSNP:772250170
2094 2094 c, g dbSNP:748359980
2099 2099 c, g dbSNP:774595077
2101 2101 c, t dbSNP:200228050
2102 2102 a, c, g, t dbSNP:148234743
2103 2103 a, g dbSNP:142846443
2131 2131 a, c dbSNP:780812527
2136 2136 c, g dbSNP:193013939
2148 2148 c, g dbSNP:751163405
2151 2151 c, t dbSNP:777431045
2156 2156 c, t dbSNP:758204799
2157 2157 a, g dbSNP:371885410
2158 2158 c, t dbSNP:765135930
2162 2162 a, g dbSNP:760782629
2173 2173 c, t dbSNP:750531364
2179 2179 c, g dbSNP:767529331
2181 2181 a, g dbSNP:761946767
2184 2184 a, g dbSNP:368612500
2187 2187 a, g dbSNP:768960007
2188 2188 c, t dbSNP:145711536
2192 2192 a, g dbSNP:372298532
2205 2205 a, c dbSNP:770459080
2207 2207 c, t dbSNP:746331652
2230 2230 c, t dbSNP:202190731
2240 2240 c, t dbSNP:761940023
2243 2243 c, t dbSNP:751777823
2248 2248 a, g dbSNP:368173480
2261 2261 a, g dbSNP:764350708
2269 2269 a, t dbSNP:140472966
2277 2277 a, g dbSNP:776022988
2278 2278 a, g dbSNP:555902969
2280 2280 a, g dbSNP:760123082
2286 2286 c, t dbSNP:777271187
2289 2289 g, t dbSNP:770401147
2291 2291 c, t dbSNP:746506055
2292 2292 c, g dbSNP:772779235
2319 2319 a, g dbSNP:375706546
2321 2321 c, t dbSNP:771787159
2322 2322 a, g dbSNP:141122478
2331 2331 c, t dbSNP:147324335
2335 2335 c, t dbSNP:778685576
2342 2342 a, g dbSNP:6123
2349 2349 a, t dbSNP:749281590
2352 2352 a, c dbSNP:780019458
2358 2358 a, c dbSNP:757325057
2361 2361 a, g dbSNP:751695331
2363 2363 g, t dbSNP:764034062
2372 2372 a, g, t dbSNP:267606981
2377 2377 c, t dbSNP:752897750
2378 2378 c, t dbSNP:539986049
2383 2383 a, c dbSNP:556217785
2387 2387 c, g dbSNP:777322625
2389 2389 c, t dbSNP:766878244
2390 2390 g, t dbSNP:761046948
2393 2393 a, g dbSNP:772800528
2397 2397 a, c dbSNP:771423259
2402 2402 g, t dbSNP:747865234
2404 2404 a, c dbSNP:199820528
2406 2406 a, t dbSNP:773981911
2409 2409 a, g dbSNP:772879763
2417 2417 a, g dbSNP:768490238
2418 2418 -, ta dbSNP:778661381
2418 2418 c, t dbSNP:539591634
2457 2457 a, g dbSNP:570472005
2468 2468 c, t dbSNP:553753206
2527 2527 a, t dbSNP:534064879
2567 2567 a, c dbSNP:555142434
2569 2569 c, t dbSNP:182088150
2590 2590 a, c dbSNP:548497101
2593 2593 -, a dbSNP:776969264
2659 2659 a, g dbSNP:531381061
2673 2673 a, c dbSNP:569117154
2694 2694 a, g dbSNP:768432447
2741 2741 c, t dbSNP:535034037
2742 2742 a, g dbSNP:144135580
2752 2752 a, g, t dbSNP:138546241
2794 2794 c, g dbSNP:770100925
2826 2826 a, g dbSNP:539871594
2841 2841 a, c dbSNP:147496684
2876 2876 c, t dbSNP:562230741
2888 2888 g, t dbSNP:542539134
2892 2892 a, c dbSNP:9681204
2902 2902 c, t dbSNP:556348407
2991 2991 c, g dbSNP:746059789
2995 2995 a, c dbSNP:781732448
3002 3002 g, t dbSNP:545846439
3058 3058 a, g dbSNP:550909963
3065 3065 a, g dbSNP:189450409
3072 3072 c, g dbSNP:778445562
3109 3109 c, g dbSNP:538937681
3114 3114 c, t dbSNP:374824636
3126 3126 a, c dbSNP:60153116
3151 3151 g, t dbSNP:112945093
3155 3155 c, t dbSNP:137965257
3205 3205 a, g dbSNP:574802526
3206 3206 c, t dbSNP:757503126
3303 3303 c, t dbSNP:554561641
3304 3304 a, g dbSNP:558951098
3344 3344 c, t dbSNP:538178021
3345 3345 g, t dbSNP:569034825
3348 3348 c, t dbSNP:552407111
3364 3364 g, t dbSNP:538711279
3389 3389 c, t dbSNP:566589234
3418 3418 c, t dbSNP:546710591
3448 3448 c, t dbSNP:753438503
3475 3475 a, g dbSNP:779418455
3477 3477 c, t dbSNP:186560028
3491 3491 c, t dbSNP:556433008
3492 3492 a, g dbSNP:548591822
3542 3542 a, g dbSNP:140073790
3563 3563 a, t dbSNP:562714994

Target ORF information:

RefSeq Version NM_000313
Organism Homo sapiens (human)
Definition Homo sapiens protein S (alpha) (PROS1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000313

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGAGGGTCC TGGGTGGGCG CTGCGGGGCG CTGCTGGCGT GTCTCCTCCT AGTGCTTCCC 
GTCTCAGAGG CAAACTTTTT GTCAAAGCAA CAGGCTTCAC AAGTCCTGGT TAGGAAGCGT
CGTGCAAATT CTTTACTTGA AGAAACCAAA CAGGGTAATC TTGAAAGAGA ATGCATCGAA
GAACTGTGCA ATAAAGAAGA AGCCAGGGAG GTCTTTGAAA ATGACCCGGA AACGGATTAT
TTTTATCCAA AATACTTAGT TTGTCTTCGC TCTTTTCAAA CTGGGTTATT CACTGCTGCA
CGTCAGTCAA CTAATGCTTA TCCTGACCTA AGAAGCTGTG TCAATGCCAT TCCAGACCAG
TGTAGTCCTC TGCCATGCAA TGAAGATGGA TATATGAGCT GCAAAGATGG AAAAGCTTCT
TTTACTTGCA CTTGTAAACC AGGTTGGCAA GGAGAAAAGT GTGAATTTGA CATAAATGAA
TGCAAAGATC CCTCAAATAT AAATGGAGGT TGCAGTCAAA TTTGTGATAA TACACCTGGA
AGTTACCACT GTTCCTGTAA AAATGGTTTT GTTATGCTTT CAAATAAGAA AGATTGTAAA
GATGTGGATG AATGCTCTTT GAAGCCAAGC ATTTGTGGCA CAGCTGTGTG CAAGAACATC
CCAGGAGATT TTGAATGTGA ATGCCCCGAA GGCTACAGAT ATAATCTCAA ATCAAAGTCT
TGTGAAGATA TAGATGAATG CTCTGAGAAC ATGTGTGCTC AGCTTTGTGT CAATTACCCT
GGAGGTTACA CTTGCTATTG TGATGGGAAG AAAGGATTCA AACTTGCCCA AGATCAGAAG
AGTTGTGAGG TTGTTTCAGT GTGCCTTCCC TTGAACCTTG ACACAAAGTA TGAATTACTT
TACTTGGCGG AGCAGTTTGC AGGGGTTGTT TTATATTTAA AATTTCGTTT GCCAGAAATC
AGCAGATTTT CAGCAGAATT TGATTTCCGG ACATATGATT CAGAAGGCGT GATACTGTAC
GCAGAATCTA TCGATCACTC AGCGTGGCTC CTGATTGCAC TTCGTGGTGG AAAGATTGAA
GTTCAGCTTA AGAATGAACA TACATCCAAA ATCACAACTG GAGGTGATGT TATTAATAAT
GGTCTATGGA ATATGGTGTC TGTGGAAGAA TTAGAACATA GTATTAGCAT TAAAATAGCT
AAAGAAGCTG TGATGGATAT AAATAAACCT GGACCCCTTT TTAAGCCGGA AAATGGATTG
CTGGAAACCA AAGTATACTT TGCAGGATTC CCTCGGAAAG TGGAAAGTGA ACTCATTAAA
CCGATTAACC CTCGTCTAGA TGGATGTATA CGAAGCTGGA ATTTGATGAA GCAAGGAGCT
TCTGGAATAA AGGAAATTAT TCAAGAAAAA CAAAATAAGC ATTGCCTGGT TACTGTGGAG
AAGGGCTCCT ACTATCCTGG TTCTGGAATT GCTCAATTTC ACATAGATTA TAATAATGTA
TCCAGTGCTG AGGGTTGGCA TGTAAATGTG ACCTTGAATA TTCGTCCATC CACGGGCACT
GGTGTTATGC TTGCCTTGGT TTCTGGTAAC AACACAGTGC CCTTTGCTGT GTCCTTGGTG
GACTCCACCT CTGAAAAATC ACAGGATATT CTGTTATCTG TTGAAAATAC TGTAATATAT
CGGATACAGG CCCTAAGTCT ATGTTCCGAT CAACAATCTC ATCTGGAATT TAGAGTCAAC
AGAAACAATC TGGAGTTGTC GACACCACTT AAAATAGAAA CCATCTCCCA TGAAGACCTT
CAAAGACAAC TTGCCGTCTT GGACAAAGCA ATGAAAGCAA AAGTGGCCAC ATACCTGGGT
GGCCTTCCAG ATGTTCCATT CAGTGCCACA CCAGTGAATG CCTTTTATAA TGGCTGCATG
GAAGTGAATA TTAATGGTGT ACAGTTGGAT CTGGATGAAG CCATTTCTAA ACATAATGAT
ATTAGAGCTC ACTCATGTCC ATCAGTTTGG AAAAAGACAA AGAATTCTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.