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PRSS1 protease, serine, 1 (trypsin 1) [Homo sapiens (human)]

Gene Symbol PRSS1
Entrez Gene ID 5644
Full Name protease, serine, 1 (trypsin 1)
Synonyms TRP1, TRY1, TRY4, TRYP1
General protein information
Preferred Names
trypsin-1
Names
trypsin-1
beta-trypsin
trypsinogen 1
trypsinogen A
digestive zymogen
cationic trypsinogen
nonfunctional trypsin 1
NP_002760.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34

Summary This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

276000

Disorder Html: Trypsinogen deficiency (1); Pancreatitis, hereditary, 167800 (3)





The following PRSS1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu59966 XM_011516411 PREDICTED: Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu19842 NM_002769 Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$188.3
$269

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu59966
Accession Version XM_011516411.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1419bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product trypsin-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007933.16) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011514713.1
CDS39..1457
Misc Feature(1)93..395(+)
Misc Feature(2)123..377(+)
Misc Feature(3)780..1430(+)
Misc Feature(4)783..1439(+)
Misc Feature(5)783..785(+)
Misc Feature(6)900..1313(+)
Misc Feature(7)1293..1364(+)
Translation
Position Chain Variation Link
5 5 g, t dbSNP:776478168
7 7 c, t dbSNP:535389084
18 18 -, gggaga dbSNP:763987132
19 19 a, g dbSNP:764807387
30 30 c, g dbSNP:376710711
33 33 c, g, t dbSNP:367783161
40 40 c, t dbSNP:752047883
45 45 a, t dbSNP:757777650
53 53 a, g dbSNP:781468016
54 54 a, c dbSNP:750757105
64 64 a, t dbSNP:361328
65 65 c, g dbSNP:780379542
67 67 a, g dbSNP:370553205
74 74 c, t dbSNP:369390159
75 75 a, t dbSNP:773736058
76 76 c, t dbSNP:761345164
77 77 c, t dbSNP:767929659
86 86 c, t dbSNP:773902860
93 93 -, at dbSNP:769946787
104 104 c, g dbSNP:372904157
110 110 c, t dbSNP:375871498
111 111 a, g dbSNP:200326773
115 115 a, g dbSNP:754201653
116 116 c, t dbSNP:755164938
118 118 c, t dbSNP:765463018
126 126 a, c, t dbSNP:369087862
127 127 a, g dbSNP:777801377
129 129 a, g dbSNP:373010776
143 143 a, c, g dbSNP:570979355
158 158 c, t dbSNP:531887754
159 159 a, g dbSNP:550118360
168 168 a, g dbSNP:377067576
175 175 c, t dbSNP:747731032
178 178 a, t dbSNP:771648371
182 182 c, t dbSNP:772840946
183 183 c, t dbSNP:371471590
185 185 a, g dbSNP:761280802
190 190 a, g dbSNP:375926475
198 198 c, g, t dbSNP:535770418
199 199 c, t dbSNP:13228799
201 201 a, g, t dbSNP:144203472
203 203 a, g dbSNP:760690905
205 205 a, g dbSNP:753004816
208 208 g, t dbSNP:758546481
221 221 c, t dbSNP:267601346
222 222 a, g dbSNP:377648489
225 225 a, g dbSNP:764218699
239 239 c, t dbSNP:751580201
241 241 c, g dbSNP:756047676
246 246 a, g dbSNP:565323486
247 247 a, c dbSNP:539064549
248 248 c, t dbSNP:754848052
254 254 c, t dbSNP:548232086
257 257 c, g dbSNP:778536795
262 262 g, t dbSNP:747899470
270 270 a, c, g dbSNP:771834679
271 271 c, t dbSNP:146048073
273 273 c, g dbSNP:113722411
287 287 a, c dbSNP:777330589
291 291 c, t dbSNP:367943558
292 292 a, g, t dbSNP:529057014
295 295 a, c dbSNP:775705870
315 315 c, t dbSNP:371557034
330 330 a, c dbSNP:17214
331 331 c, t dbSNP:751668130
332 332 a, g dbSNP:761831169
334 334 a, g dbSNP:752177825
335 335 a, c dbSNP:753850128
347 347 a, c, t dbSNP:555266426
353 353 a, g dbSNP:752370993
356 356 a, t dbSNP:758158810
359 359 c, g dbSNP:367582255
360 360 c, t dbSNP:746642354
365 365 c, t dbSNP:770606486
366 366 a, g dbSNP:372238829
368 368 c, t dbSNP:746447004
374 374 c, t dbSNP:770143484
376 376 c, t dbSNP:775926112
381 381 a, c, t dbSNP:375342247
382 382 a, g dbSNP:369582960
385 385 a, g, t dbSNP:761988367
387 387 a, g dbSNP:750453712
395 395 a, c dbSNP:759528367
402 402 a, g dbSNP:765048267
405 405 a, c dbSNP:541317945
410 410 a, g dbSNP:758322297
419 419 c, g dbSNP:763953789
427 427 c, t dbSNP:753577171
443 443 c, g, t dbSNP:117291098
447 447 c, t dbSNP:562557111
461 461 c, g dbSNP:140098614
476 476 a, g dbSNP:571660082
491 491 a, c, g dbSNP:374043338
510 510 a, c dbSNP:4726576
518 518 c, t dbSNP:569501740
524 524 a, c dbSNP:536932034
530 530 a, g dbSNP:139432246
541 541 c, t dbSNP:572772014
544 544 c, g dbSNP:537964595
546 546 c, g dbSNP:762618250
561 561 a, g dbSNP:539853065
567 567 c, t dbSNP:754367025
576 576 a, g dbSNP:558584560
589 589 a, g dbSNP:576859120
603 603 c, g dbSNP:757749046
622 622 c, t dbSNP:544320206
623 623 a, g dbSNP:562324506
629 629 c, t dbSNP:529852942
645 645 c, g dbSNP:180743782
662 662 c, t dbSNP:183575212
663 663 a, c, g dbSNP:764706324
664 664 a, t dbSNP:780768878
667 667 a, g dbSNP:745310113
668 668 c, g, t dbSNP:372312254
677 677 c, t dbSNP:749773332
678 678 a, g dbSNP:377134514
681 681 -, tcc dbSNP:545380933
682 682 c, t dbSNP:199713984
684 684 -, tcc dbSNP:386134264
686 686 c, t dbSNP:774690110
701 701 a, c dbSNP:748424130
704 704 a, c dbSNP:369627514
707 707 c, t dbSNP:546669095
709 709 a, c dbSNP:760624726
712 712 a, c dbSNP:766465080
713 713 c, t dbSNP:775612238
717 717 a, c dbSNP:762980620
719 719 a, g, t dbSNP:140591237
721 721 c, t dbSNP:374597855
724 724 c, t dbSNP:767036052
725 725 c, t dbSNP:749968829
727 727 c, t dbSNP:755628827
728 728 c, g dbSNP:779583824
735 735 a, g dbSNP:749856663
736 736 c, t dbSNP:201027769
742 742 c, t dbSNP:755460834
743 743 g, t dbSNP:779260304
745 745 a, c dbSNP:748442280
748 748 c, g dbSNP:772363999
751 751 c, t dbSNP:773357729
753 753 c, g, t dbSNP:747228052
756 756 a, g, t dbSNP:749319393
757 757 c, g dbSNP:200665515
760 760 c, t dbSNP:202003805
762 762 c, t dbSNP:770782578
763 763 a, c dbSNP:776401461
764 764 c, g dbSNP:745538166
765 765 -, t dbSNP:779352917
769 769 a, g dbSNP:769369961
771 771 a, g dbSNP:774895653
776 776 -, gac dbSNP:748666329
776 776 c, t dbSNP:762477127
778 778 a, g dbSNP:397507442
781 781 a, g dbSNP:111033567
782 782 a, g dbSNP:763492611
783 783 a, c dbSNP:774960689
784 784 -, tgacaagat dbSNP:397507441
785 785 c, t dbSNP:372637371
786 786 a, c, g dbSNP:768051473
787 787 c, t dbSNP:564368252
789 789 c, g dbSNP:766579839
790 790 a, g dbSNP:753883523
791 791 a, g dbSNP:755129029
795 795 -, a dbSNP:772505940
799 799 a, c, t dbSNP:111033566
800 800 c, g, t dbSNP:747010881
803 803 g, t dbSNP:780969708
804 804 a, g dbSNP:700323
806 806 a, g dbSNP:745623963
820 820 c, g dbSNP:769459903
825 825 a, c, g dbSNP:775259109
829 829 c, t dbSNP:397507439
832 832 a, c, t dbSNP:768277012
834 834 c, t dbSNP:369646357
843 843 a, g dbSNP:772636606
844 844 c, g dbSNP:773739445
845 845 c, g dbSNP:761068371
857 857 c, t dbSNP:372007913
859 859 a, g, t dbSNP:138464021
863 863 a, c, t dbSNP:765375872
867 867 c, g dbSNP:757218067
869 869 c, t dbSNP:781059471
870 870 -, atcaacg dbSNP:773733013
871 871 a, t dbSNP:149246646
874 874 a, g dbSNP:144422014
875 875 c, g, t dbSNP:148440491
879 879 c, t dbSNP:147366981
882 882 g, t dbSNP:778570468
890 890 a, g dbSNP:747617548
895 895 a, c dbSNP:370761165
898 898 -, gcca dbSNP:747194334
898 898 c, g dbSNP:149455681
899 899 a, c, t dbSNP:199713773
900 900 c, t dbSNP:11553851
901 901 a, g dbSNP:776806418
909 909 a, t dbSNP:759809930
913 913 c, t dbSNP:765342413
915 915 c, t dbSNP:145867820
916 916 a, g, t dbSNP:757111793
924 924 a, g dbSNP:745551657
928 928 c, g dbSNP:769266571
936 936 a, g dbSNP:779649447
944 944 c, t dbSNP:555535168
945 945 a, g dbSNP:768255958
947 947 c, t dbSNP:200801370
948 948 a, g dbSNP:111033564
953 953 c, t dbSNP:772622287
956 956 a, c, g dbSNP:142476093
960 960 c, g dbSNP:372411481
965 965 c, t dbSNP:754070076
966 966 a, g dbSNP:759654213
968 968 a, g dbSNP:376671702
969 969 c, t dbSNP:146398318
972 972 a, t dbSNP:757132372
974 974 a, c dbSNP:767354237
977 977 c, g dbSNP:199836666
978 978 a, t dbSNP:755816580
980 980 a, c, t dbSNP:779618969
983 983 a, g dbSNP:371037592
984 984 a, g dbSNP:778549864
985 985 c, t dbSNP:748678217
992 992 c, t dbSNP:139664510
995 995 c, t dbSNP:545007137
996 996 c, g, t dbSNP:201775810
997 997 a, g dbSNP:375820192
998 998 c, t dbSNP:759742265
1003 1003 c, t dbSNP:765315575
1004 1004 a, c, g, t dbSNP:200763933
1005 1005 a, c dbSNP:750348889
1010 1010 c, t dbSNP:373659879
1011 1011 a, g dbSNP:199507985
1013 1013 c, t dbSNP:753600288
1015 1015 -, cc, ct dbSNP:759005506
1017 1017 -, aa dbSNP:747427587
1017 1017 a, g dbSNP:754618801
1018 1018 a, g dbSNP:778568523
1026 1026 a, g dbSNP:200254850
1033 1033 a, g dbSNP:758965932
1036 1036 -, t dbSNP:771171976
1038 1038 a, c dbSNP:201165989
1041 1041 c, t dbSNP:747546710
1043 1043 a, g dbSNP:771259654
1055 1055 c, t dbSNP:776924834
1056 1056 a, t dbSNP:606231344
1059 1059 c, t dbSNP:387906698
1060 1060 a, c, g, t dbSNP:199769221
1061 1061 a, t dbSNP:773085470
1064 1064 a, c dbSNP:606231346
1065 1065 a, g dbSNP:766098231
1066 1066 a, g, t dbSNP:753618826
1067 1067 a, c dbSNP:606231347
1073 1073 c, t dbSNP:606231348
1074 1074 a, g, t dbSNP:199422123
1077 1077 c, t dbSNP:111033568
1078 1078 at, gc dbSNP:267606982
1078 1078 a, g dbSNP:111033565
1079 1079 c, t dbSNP:201487096
1080 1080 a, g, t dbSNP:144403091
1086 1086 a, g dbSNP:200976326
1090 1090 -, tc dbSNP:781337582
1096 1096 a, t dbSNP:749518244
1097 1097 a, g dbSNP:549140095
1099 1099 a, c dbSNP:768673799
1101 1101 a, c, g dbSNP:11553845
1102 1102 c, t dbSNP:193922655
1103 1103 c, t dbSNP:561097415
1104 1104 a, g, t dbSNP:141011596
1104 1104 -, g dbSNP:746107631
1106 1106 c, t dbSNP:200699755
1108 1108 -, ct dbSNP:769708503
1108 1108 a, c dbSNP:759452330
1109 1109 c, t dbSNP:199931737
1109 1109 -, t dbSNP:775571840
1111 1111 c, g dbSNP:193922656
1113 1113 a, g dbSNP:752456117
1115 1115 c, t dbSNP:762609976
1116 1116 a, g dbSNP:199637670
1118 1118 g, t dbSNP:751042949
1123 1123 c, t dbSNP:117497341
1124 1124 a, c, g, t dbSNP:369013081
1125 1125 a, g dbSNP:11553849
1127 1127 c, g dbSNP:749482440
1128 1128 a, t dbSNP:397507440
1129 1129 c, g dbSNP:768853338
1130 1130 c, t dbSNP:141847266
1135 1135 a, t dbSNP:748208676
1136 1136 c, g dbSNP:772256079
1139 1139 c, t dbSNP:776749513
1142 1142 a, c dbSNP:745788965
1153 1153 a, c dbSNP:769724683
1155 1155 ct, gc dbSNP:386718744
1155 1155 c, g dbSNP:775290386
1156 1156 c, g, t dbSNP:762545562
1157 1157 a, c, g, t dbSNP:11553844
1160 1160 a, c, t dbSNP:372698855
1166 1166 c, t dbSNP:147765409
1167 1167 a, g dbSNP:766731858
1168 1168 c, g dbSNP:770315312
1169 1169 c, t dbSNP:777261723
1170 1170 a, c, g dbSNP:61735002
1171 1171 a, g dbSNP:753073310
1175 1175 c, t dbSNP:763292560
1181 1181 c, t dbSNP:146076691
1182 1182 a, c, g dbSNP:200890507
1187 1187 a, g, t dbSNP:781123735
1188 1188 c, t dbSNP:754802107
1192 1192 a, g, t dbSNP:778796800
1193 1193 c, t dbSNP:200267714
1195 1195 c, t dbSNP:777441424
1199 1199 c, t dbSNP:6666
1200 1200 a, g dbSNP:557691366
1202 1202 g, t dbSNP:775936808
1203 1203 a, c dbSNP:760120835
1203 1203 -, c dbSNP:766199324
1207 1207 c, t dbSNP:202228418
1210 1210 c, t dbSNP:776120935
1214 1214 c, g dbSNP:763453065
1215 1215 a, c dbSNP:575283731
1219 1219 a, c dbSNP:751892043
1221 1221 a, g dbSNP:201550522
1222 1222 a, t dbSNP:767634678
1223 1223 a, c, g dbSNP:750427023
1225 1225 a, g dbSNP:200973660
1226 1226 a, t dbSNP:752598739
1227 1227 c, g dbSNP:758254763
1231 1231 c, g dbSNP:777531305
1234 1234 c, t dbSNP:746669985
1236 1236 c, t dbSNP:756821075
1239 1239 c, t dbSNP:11553847
1247 1247 a, g dbSNP:267601347
1252 1252 c, t dbSNP:745420768
1253 1253 c, g dbSNP:769319141
1254 1254 a, g dbSNP:376907511
1255 1255 a, g dbSNP:201719096
1257 1257 a, g dbSNP:769160661
1260 1260 a, g dbSNP:200070487
1261 1261 c, t dbSNP:762123204
1264 1264 -, tc dbSNP:753370538
1264 1264 c, t dbSNP:11553848
1265 1265 c, t dbSNP:767583768
1274 1274 c, t dbSNP:1804561
1280 1280 c, t dbSNP:377124851
1281 1281 g, t dbSNP:11553850
1283 1283 a, g dbSNP:766441257
1284 1284 a, g dbSNP:752688735
1298 1298 a, c dbSNP:758274784
1299 1299 g, t dbSNP:763907908
1301 1301 c, t dbSNP:751264273
1302 1302 c, t dbSNP:757054367
1318 1318 c, g dbSNP:199531292
1319 1319 c, t dbSNP:368414354
1324 1324 c, t dbSNP:758874255
1326 1326 a, g dbSNP:778021503
1327 1327 a, t dbSNP:747422004
1328 1328 c, t dbSNP:771252966
1329 1329 a, t dbSNP:781457756
1330 1330 c, g dbSNP:150930992
1334 1334 a, c, t dbSNP:146995038
1336 1336 c, g dbSNP:189270875
1338 1338 c, g dbSNP:140793689
1339 1339 a, g dbSNP:576596527
1343 1343 c, t dbSNP:760589518
1350 1350 a, g dbSNP:200902389
1355 1355 a, c, g dbSNP:141697925
1358 1358 c, t dbSNP:764659707
1364 1364 c, t dbSNP:562372415
1365 1365 g, t dbSNP:574391339
1366 1366 a, t dbSNP:199878511
1367 1367 c, t dbSNP:372703495
1372 1372 a, g dbSNP:757674146
1379 1379 a, g dbSNP:756009547
1387 1387 a, c, g, t dbSNP:541223359
1388 1388 a, g dbSNP:375871958
1394 1394 a, g dbSNP:780015944
1400 1400 c, t dbSNP:749438727
1401 1401 a, t dbSNP:768590288
1415 1415 a, c dbSNP:773353079
1418 1418 c, t dbSNP:1042921
1422 1422 a, g dbSNP:150083974
1424 1424 a, c dbSNP:138362833
1434 1434 a, g, t dbSNP:141554682
1439 1439 c, g dbSNP:774973548
1443 1443 c, g dbSNP:762589386
1444 1444 c, t dbSNP:763496896
1451 1451 c, t dbSNP:6667
1452 1452 a, g dbSNP:757690615
1459 1459 g, t dbSNP:749220563
1460 1460 c, t dbSNP:767895782
1465 1465 a, g dbSNP:750733084
1466 1466 g, t dbSNP:756416791
1468 1468 a, c dbSNP:780367890
1469 1469 c, t dbSNP:749470007
1470 1470 c, g dbSNP:544276930
1474 1474 g, t dbSNP:755145727
1482 1482 a, t dbSNP:779079467
1484 1484 c, t dbSNP:746949250
1489 1489 a, g dbSNP:770953697
1490 1490 c, t dbSNP:776590758
1499 1499 c, g, t dbSNP:745715288
1503 1503 c, g, t dbSNP:775269865
1512 1512 c, t dbSNP:528489122

Target ORF information:

RefSeq Version XM_011516411
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516411

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19842
Accession Version NM_002769.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 744bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product trypsin-1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP321999.1, BC128226.1 and CA948204.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2010 this sequence version replaced gi:183213120. Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA777765.1, BC128226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG
AACACCATAG CTGCCAATAG CTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002760.1
CDS18..761
Misc Feature(1)84..734(+)
Misc Feature(2)87..743(+)
Misc Feature(3)87..89(+)
Misc Feature(4)204..617(+)
Misc Feature(5)381..383(+)
Misc Feature(6)477..479(+)
Misc Feature(7)477..479(+)
Misc Feature(8)597..668(+)
Misc Feature(9)597..599(+)
Exon (1)1..57
Gene:PRSS1
Gene Synonym:
Exon (2)58..217
Gene:PRSS1
Gene Synonym:
Exon (3)218..471
Gene:PRSS1
Gene Synonym:
Exon (4)472..608
Gene:PRSS1
Gene Synonym:
Exon (5)609..817
Gene:PRSS1
Gene Synonym:
Translation
Position Chain Variation Link
5 5 a, c dbSNP:748424130
8 8 a, c dbSNP:369627514
11 11 c, t dbSNP:546669095
13 13 a, c dbSNP:760624726
16 16 a, c dbSNP:766465080
17 17 c, t dbSNP:775612238
21 21 a, c dbSNP:762980620
23 23 a, g, t dbSNP:140591237
25 25 c, t dbSNP:374597855
28 28 c, t dbSNP:767036052
29 29 c, t dbSNP:749968829
31 31 c, t dbSNP:755628827
32 32 c, g dbSNP:779583824
39 39 a, g dbSNP:749856663
40 40 c, t dbSNP:201027769
46 46 c, t dbSNP:755460834
47 47 g, t dbSNP:779260304
49 49 a, c dbSNP:748442280
52 52 c, g dbSNP:772363999
55 55 c, t dbSNP:773357729
57 57 c, g, t dbSNP:747228052
60 60 a, g, t dbSNP:749319393
61 61 c, g dbSNP:200665515
64 64 c, t dbSNP:202003805
66 66 c, t dbSNP:770782578
67 67 a, c dbSNP:776401461
68 68 c, g dbSNP:745538166
69 69 -, t dbSNP:779352917
73 73 a, g dbSNP:769369961
75 75 a, g dbSNP:774895653
80 80 -, gac dbSNP:748666329
80 80 c, t dbSNP:762477127
82 82 a, g dbSNP:397507442
85 85 a, g dbSNP:111033567
86 86 a, g dbSNP:763492611
87 87 a, c dbSNP:774960689
88 88 -, tgacaagat dbSNP:397507441
89 89 c, t dbSNP:372637371
90 90 a, c, g dbSNP:768051473
91 91 c, t dbSNP:564368252
93 93 c, g dbSNP:766579839
94 94 a, g dbSNP:753883523
95 95 a, g dbSNP:755129029
99 99 -, a dbSNP:772505940
103 103 a, c, t dbSNP:111033566
104 104 c, g, t dbSNP:747010881
107 107 g, t dbSNP:780969708
108 108 a, g dbSNP:700323
110 110 a, g dbSNP:745623963
124 124 c, g dbSNP:769459903
129 129 a, c, g dbSNP:775259109
133 133 c, t dbSNP:397507439
136 136 a, c, t dbSNP:768277012
138 138 c, t dbSNP:369646357
147 147 a, g dbSNP:772636606
148 148 c, g dbSNP:773739445
149 149 c, g dbSNP:761068371
161 161 c, t dbSNP:372007913
163 163 a, g, t dbSNP:138464021
167 167 a, c, t dbSNP:765375872
171 171 c, g dbSNP:757218067
173 173 c, t dbSNP:781059471
174 174 -, atcaacg dbSNP:773733013
175 175 a, t dbSNP:149246646
178 178 a, g dbSNP:144422014
179 179 c, g, t dbSNP:148440491
183 183 c, t dbSNP:147366981
186 186 g, t dbSNP:778570468
194 194 a, g dbSNP:747617548
199 199 a, c dbSNP:370761165
202 202 -, gcca dbSNP:747194334
202 202 c, g dbSNP:149455681
203 203 a, c, t dbSNP:199713773
204 204 c, t dbSNP:11553851
205 205 a, g dbSNP:776806418
213 213 a, t dbSNP:759809930
217 217 c, t dbSNP:765342413
219 219 c, t dbSNP:145867820
220 220 a, g, t dbSNP:757111793
228 228 a, g dbSNP:745551657
232 232 c, g dbSNP:769266571
240 240 a, g dbSNP:779649447
248 248 c, t dbSNP:555535168
249 249 a, g dbSNP:768255958
251 251 c, t dbSNP:200801370
252 252 a, g dbSNP:111033564
257 257 c, t dbSNP:772622287
260 260 a, c, g dbSNP:142476093
264 264 c, g dbSNP:372411481
269 269 c, t dbSNP:754070076
270 270 a, g dbSNP:759654213
272 272 a, g dbSNP:376671702
273 273 c, t dbSNP:146398318
276 276 a, t dbSNP:757132372
278 278 a, c dbSNP:767354237
281 281 c, g dbSNP:199836666
282 282 a, t dbSNP:755816580
284 284 a, c, t dbSNP:779618969
287 287 a, g dbSNP:371037592
288 288 a, g dbSNP:778549864
289 289 c, t dbSNP:748678217
296 296 c, t dbSNP:139664510
299 299 c, t dbSNP:545007137
300 300 c, g, t dbSNP:201775810
301 301 a, g dbSNP:375820192
302 302 c, t dbSNP:759742265
307 307 c, t dbSNP:765315575
308 308 a, c, g, t dbSNP:200763933
309 309 a, c dbSNP:750348889
314 314 c, t dbSNP:373659879
315 315 a, g dbSNP:199507985
317 317 c, t dbSNP:753600288
319 319 -, cc, ct dbSNP:759005506
321 321 -, aa dbSNP:747427587
321 321 a, g dbSNP:754618801
322 322 a, g dbSNP:778568523
330 330 a, g dbSNP:200254850
337 337 a, g dbSNP:758965932
340 340 -, t dbSNP:771171976
342 342 a, c dbSNP:201165989
345 345 c, t dbSNP:747546710
347 347 a, g dbSNP:771259654
359 359 c, t dbSNP:776924834
360 360 a, t dbSNP:606231344
363 363 c, t dbSNP:387906698
364 364 a, c, g, t dbSNP:199769221
365 365 a, t dbSNP:773085470
368 368 a, c dbSNP:606231346
369 369 a, g dbSNP:766098231
370 370 a, g, t dbSNP:753618826
371 371 a, c dbSNP:606231347
377 377 c, t dbSNP:606231348
378 378 a, g, t dbSNP:199422123
381 381 c, t dbSNP:111033568
382 382 at, gc dbSNP:267606982
382 382 a, g dbSNP:111033565
383 383 c, t dbSNP:201487096
384 384 a, g, t dbSNP:144403091
390 390 a, g dbSNP:200976326
394 394 -, tc dbSNP:781337582
400 400 a, t dbSNP:749518244
401 401 a, g dbSNP:549140095
403 403 a, c dbSNP:768673799
405 405 a, c, g dbSNP:11553845
406 406 c, t dbSNP:193922655
407 407 c, t dbSNP:561097415
408 408 a, g, t dbSNP:141011596
408 408 -, g dbSNP:746107631
410 410 c, t dbSNP:200699755
412 412 -, ct dbSNP:769708503
412 412 a, c dbSNP:759452330
413 413 c, t dbSNP:199931737
413 413 -, t dbSNP:775571840
415 415 c, g dbSNP:193922656
417 417 a, g dbSNP:752456117
419 419 c, t dbSNP:762609976
420 420 a, g dbSNP:199637670
422 422 g, t dbSNP:751042949
427 427 c, t dbSNP:117497341
428 428 a, c, g, t dbSNP:369013081
429 429 a, g dbSNP:11553849
431 431 c, g dbSNP:749482440
432 432 a, t dbSNP:397507440
433 433 c, g dbSNP:768853338
434 434 c, t dbSNP:141847266
439 439 a, t dbSNP:748208676
440 440 c, g dbSNP:772256079
443 443 c, t dbSNP:776749513
446 446 a, c dbSNP:745788965
457 457 a, c dbSNP:769724683
459 459 ct, gc dbSNP:386718744
459 459 c, g dbSNP:775290386
460 460 c, g, t dbSNP:762545562
461 461 a, c, g, t dbSNP:11553844
464 464 a, c, t dbSNP:372698855
470 470 c, t dbSNP:147765409
471 471 a, g dbSNP:766731858
472 472 c, g dbSNP:770315312
473 473 c, t dbSNP:777261723
474 474 a, c, g dbSNP:61735002
475 475 a, g dbSNP:753073310
479 479 c, t dbSNP:763292560
485 485 c, t dbSNP:146076691
486 486 a, c, g dbSNP:200890507
491 491 a, g, t dbSNP:781123735
492 492 c, t dbSNP:754802107
496 496 a, g, t dbSNP:778796800
497 497 c, t dbSNP:200267714
499 499 c, t dbSNP:777441424
503 503 c, t dbSNP:6666
504 504 a, g dbSNP:557691366
506 506 g, t dbSNP:775936808
507 507 a, c dbSNP:760120835
507 507 -, c dbSNP:766199324
511 511 c, t dbSNP:202228418
514 514 c, t dbSNP:776120935
518 518 c, g dbSNP:763453065
519 519 a, c dbSNP:575283731
523 523 a, c dbSNP:751892043
525 525 a, g dbSNP:201550522
526 526 a, t dbSNP:767634678
527 527 a, c, g dbSNP:750427023
529 529 a, g dbSNP:200973660
530 530 a, t dbSNP:752598739
531 531 c, g dbSNP:758254763
535 535 c, g dbSNP:777531305
538 538 c, t dbSNP:746669985
540 540 c, t dbSNP:756821075
543 543 c, t dbSNP:11553847
551 551 a, g dbSNP:267601347
556 556 c, t dbSNP:745420768
557 557 c, g dbSNP:769319141
558 558 a, g dbSNP:376907511
559 559 a, g dbSNP:201719096
561 561 a, g dbSNP:769160661
564 564 a, g dbSNP:200070487
565 565 c, t dbSNP:762123204
568 568 -, tc dbSNP:753370538
568 568 c, t dbSNP:11553848
569 569 c, t dbSNP:767583768
578 578 c, t dbSNP:1804561
584 584 c, t dbSNP:377124851
585 585 g, t dbSNP:11553850
587 587 a, g dbSNP:766441257
588 588 a, g dbSNP:752688735
602 602 a, c dbSNP:758274784
603 603 g, t dbSNP:763907908
605 605 c, t dbSNP:751264273
606 606 c, t dbSNP:757054367
622 622 c, g dbSNP:199531292
623 623 c, t dbSNP:368414354
628 628 c, t dbSNP:758874255
630 630 a, g dbSNP:778021503
631 631 a, t dbSNP:747422004
632 632 c, t dbSNP:771252966
633 633 a, t dbSNP:781457756
634 634 c, g dbSNP:150930992
638 638 a, c, t dbSNP:146995038
640 640 c, g dbSNP:189270875
642 642 c, g dbSNP:140793689
643 643 a, g dbSNP:576596527
647 647 c, t dbSNP:760589518
654 654 a, g dbSNP:200902389
659 659 a, c, g dbSNP:141697925
662 662 c, t dbSNP:764659707
668 668 c, t dbSNP:562372415
669 669 g, t dbSNP:574391339
670 670 a, t dbSNP:199878511
671 671 c, t dbSNP:372703495
676 676 a, g dbSNP:757674146
683 683 a, g dbSNP:756009547
691 691 a, c, g, t dbSNP:541223359
692 692 a, g dbSNP:375871958
698 698 a, g dbSNP:780015944
704 704 c, t dbSNP:749438727
705 705 a, t dbSNP:768590288
719 719 a, c dbSNP:773353079
722 722 c, t dbSNP:1042921
726 726 a, g dbSNP:150083974
728 728 a, c dbSNP:138362833
738 738 a, g, t dbSNP:141554682
743 743 c, g dbSNP:774973548
747 747 c, g dbSNP:762589386
748 748 c, t dbSNP:763496896
755 755 c, t dbSNP:6667
756 756 a, g dbSNP:757690615
763 763 g, t dbSNP:749220563
764 764 c, t dbSNP:767895782
769 769 a, g dbSNP:750733084
770 770 g, t dbSNP:756416791
772 772 a, c dbSNP:780367890
773 773 c, t dbSNP:749470007
774 774 c, g dbSNP:544276930
778 778 g, t dbSNP:755145727
786 786 a, t dbSNP:779079467
788 788 c, t dbSNP:746949250
793 793 a, g dbSNP:770953697
794 794 c, t dbSNP:776590758
803 803 c, g, t dbSNP:745715288
807 807 c, g, t dbSNP:775269865
816 816 c, t dbSNP:528489122

Target ORF information:

RefSeq Version NM_002769
Organism Homo sapiens (human)
Definition Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002769

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.