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PRSS1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PRSS1
Entrez Gene ID 5644
Full Name protease, serine, 1 (trypsin 1)
Synonyms TRP1, TRY1, TRY4, TRYP1
General protein information
Preferred Names
trypsin-1
Names
trypsin-1
beta-trypsin
trypsinogen 1
trypsinogen A
digestive zymogen
cationic trypsinogen
nonfunctional trypsin 1
NP_002760.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34

Summary This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

276000

Disorder Html: Trypsinogen deficiency (1); Pancreatitis, hereditary, 167800 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011516411 XP_011514713 trypsin-1 isoform X1
NM_002769 NP_002760 trypsin-1 preproprotein



Homo sapiens (human) PRSS1 NP_002760.1
Pan troglodytes (chimpanzee) LOC100615987 XP_003318897.1
Pan troglodytes (chimpanzee) LOC742453 XP_003951210.1
Macaca mulatta (Rhesus monkey) PRSS1 NP_001040586.1
Mus musculus (house mouse) Try10 NP_001034085.1
Drosophila melanogaster (fruit fly) CG10663 NP_001097592.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PRSS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu59966 XM_011516411 PREDICTED: Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu19842
NM_002769 Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$134.50-$188.30
$269.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu59966
Clone ID Related Accession (Same CDS sequence) XM_011516411
Accession Version XM_011516411.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1419bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product trypsin-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007933.16) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011514713.1
CDS39..1457
Misc Feature(1)93..395(+)
Misc Feature(2)123..377(+)
Misc Feature(3)780..1430(+)
Misc Feature(4)783..1439(+)
Misc Feature(5)783..785(+)
Misc Feature(6)900..1313(+)
Misc Feature(7)1293..1364(+)
Translation

Target ORF information:

RefSeq Version XM_011516411
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516411

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19842
Clone ID Related Accession (Same CDS sequence) NM_002769
Accession Version NM_002769.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 744bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product trypsin-1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP321999.1, BC128226.1 and CA948204.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2010 this sequence version replaced gi:183213120. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA777765.1, BC128226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002760.1
CDS18..761
Misc Feature(1)84..734(+)
Misc Feature(2)87..743(+)
Misc Feature(3)87..89(+)
Misc Feature(4)204..617(+)
Misc Feature(5)381..383(+)
Misc Feature(6)477..479(+)
Misc Feature(7)477..479(+)
Misc Feature(8)597..668(+)
Misc Feature(9)597..599(+)
Exon (1)1..57
Gene:PRSS1
Gene Synonym:
Exon (2)58..217
Gene:PRSS1
Gene Synonym:
Exon (3)218..471
Gene:PRSS1
Gene Synonym:
Exon (4)472..608
Gene:PRSS1
Gene Synonym:
Exon (5)609..817
Gene:PRSS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002769
Organism Homo sapiens (human)
Definition Homo sapiens protease, serine, 1 (trypsin 1) (PRSS1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002769

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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