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PSEN2 presenilin 2 [Homo sapiens (human)]

Gene Symbol PSEN2
Entrez Gene ID 5664
Full Name presenilin 2
Synonyms AD3L, AD4, CMD1V, PS2, STM2
General protein information
Preferred Names
presenilin-2
Names
presenilin-2
AD5
E5-1
PS-2
AD3LP
STM-2
NP_000438.2
NP_036618.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42.13

Summary Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600759

Disorder Html: Alzheimer disease-4, 606889 (3); Cardiomyopathy, dilated, 1V, 613697





The following PSEN2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSEN2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24950 XM_005273199 PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu59977 XM_011544236 PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $199
OHu24950 NM_000447 Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu24919 NM_012486 Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu24950
Accession Version XM_005273199.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1347bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167186.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530366341. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005273256.1
CDS241..1587
Misc Feature(1)466..1557(+)
Translation
Position Chain Variation Link
2 2 c, t dbSNP:559946328
28 28 a, g dbSNP:12758915
35 35 c, t dbSNP:200954447
57 57 c, t dbSNP:149590162
77 77 a, g dbSNP:200591275
92 92 c, t dbSNP:201494032
102 102 c, t dbSNP:199632838
103 103 a, g dbSNP:200305467
109 109 a, g dbSNP:201300501
118 118 a, g dbSNP:112062360
120 120 c, t dbSNP:199803697
159 159 a, c, t dbSNP:200607063
166 166 a, g dbSNP:768399982
177 177 a, g dbSNP:570850485
184 184 c, t dbSNP:201111506
198 198 c, t dbSNP:7961
203 203 c, t dbSNP:200982557
204 204 a, g dbSNP:201820913
220 220 g, t dbSNP:200034334
228 228 c, t dbSNP:745616954
237 237 a, g dbSNP:769574014
239 239 c, t dbSNP:775235673
242 242 c, t dbSNP:762674312
244 244 c, g dbSNP:199739625
258 258 c, t dbSNP:763738488
265 265 a, g dbSNP:786205285
266 266 a, g dbSNP:200878942
267 267 c, t dbSNP:201692678
276 276 a, t dbSNP:761147472
278 278 g, t dbSNP:766853710
289 289 c, t dbSNP:199644116
293 293 c, t dbSNP:143061887
294 294 a, g dbSNP:201018913
303 303 c, g dbSNP:752960820
305 305 c, t dbSNP:552406611
306 306 a, g dbSNP:367645069
309 309 c, t dbSNP:11405
310 310 a, g dbSNP:757152552
317 317 c, t dbSNP:781116134
319 319 a, g dbSNP:147326133
320 320 c, t dbSNP:149354305
321 321 a, g dbSNP:144696679
322 322 a, c dbSNP:749015914
323 323 c, g, t dbSNP:748504448
324 324 a, g dbSNP:371475270
325 325 c, t dbSNP:142892469
326 326 a, g dbSNP:771375988
329 329 c, t dbSNP:200037771
334 334 c, g dbSNP:760011841
340 340 a, g dbSNP:200636353
351 351 c, t dbSNP:139309459
369 369 c, t dbSNP:6759
370 370 a, g dbSNP:200535276
372 372 a, t dbSNP:143227762
374 374 c, t dbSNP:751593722
376 376 c, t dbSNP:757319285
389 389 a, g dbSNP:143501870
394 394 a, g dbSNP:775935657
396 396 c, t dbSNP:749675208
402 402 c, g dbSNP:146894466
405 405 c, t dbSNP:139332886
406 406 a, g dbSNP:188598190
417 417 c, t dbSNP:767577993
423 423 c, t dbSNP:201261403
424 424 c, t dbSNP:150400387
425 425 a, g dbSNP:58973334
432 432 c, t dbSNP:201272715
434 434 a, g dbSNP:766446160
436 436 a, t dbSNP:753871802
437 437 a, g dbSNP:754836755
443 443 c, t dbSNP:765144719
445 445 a, c, g, t dbSNP:202133351
445 445 -, c dbSNP:746664513
446 446 c, g dbSNP:199968912
447 447 c, t dbSNP:142546082
448 448 a, g dbSNP:139972151
451 451 c, t dbSNP:140501902
452 452 a, g, t dbSNP:769031756
455 455 c, t dbSNP:369622085
458 458 c, g dbSNP:748397935
459 459 a, t dbSNP:772372158
462 462 c, g dbSNP:773522773
476 476 c, t dbSNP:760961297
489 489 c, t dbSNP:549378958
491 491 a, g dbSNP:776842226
494 494 c, t dbSNP:63750048
495 495 a, g dbSNP:765023751
501 501 c, t dbSNP:1046240
502 502 c, g dbSNP:758086169
519 519 c, g dbSNP:200350640
528 528 c, t dbSNP:751261061
532 532 c, t dbSNP:756899463
533 533 a, g dbSNP:780738564
534 534 c, t dbSNP:146718524
536 536 c, t dbSNP:755514702
540 540 c, t dbSNP:200801915
541 541 a, g dbSNP:373392465
546 546 a, g dbSNP:748572509
555 555 c, t dbSNP:553495122
563 563 c, g dbSNP:778247625
568 568 c, t dbSNP:199808788
569 569 a, g, t dbSNP:747296921
576 576 c, t dbSNP:200610057
588 588 c, t dbSNP:201119121
604 604 a, c dbSNP:63749851
605 605 c, g, t dbSNP:28936380
606 606 a, g dbSNP:148996705
612 612 c, t dbSNP:753371172
615 615 c, t dbSNP:758985161
618 618 a, g dbSNP:547731225
622 622 a, g dbSNP:566361436
623 623 c, t dbSNP:752002301
629 629 c, t dbSNP:63750197
630 630 c, g dbSNP:781597971
639 639 c, g dbSNP:746117072
641 641 a, g, t dbSNP:756346917
650 650 a, g dbSNP:749301595
651 651 c, t dbSNP:200924879
654 654 c, t dbSNP:747738607
655 655 a, g, t dbSNP:202178897
658 658 c, t dbSNP:773059327
659 659 c, t dbSNP:760299337
661 661 a, t dbSNP:61761208
662 662 a, t dbSNP:63750215
663 663 c, t dbSNP:116003409
664 664 a, t dbSNP:201590095
669 669 c, t dbSNP:201196514
670 670 a, c dbSNP:764718172
679 679 a, g dbSNP:201892898
681 681 c, t dbSNP:114334281
682 682 a, g dbSNP:63750812
687 687 c, t dbSNP:767835970
695 695 c, t dbSNP:199654606
700 700 a, g dbSNP:139573101
707 707 g, t dbSNP:756296193
709 709 a, g, t dbSNP:780284265
722 722 a, g dbSNP:755101354
727 727 a, c dbSNP:200931244
728 728 a, g dbSNP:778936527
735 735 c, g dbSNP:748154107
745 745 a, c dbSNP:533813519
756 756 a, g dbSNP:745582651
760 760 a, g dbSNP:61757781
764 764 c, g dbSNP:775145486
768 768 a, g dbSNP:762485322
769 769 c, g dbSNP:772480664
777 777 a, g dbSNP:201896763
778 778 c, t dbSNP:773820169
780 780 a, g dbSNP:761057590
785 785 -, gg dbSNP:757877983
785 785 a, t dbSNP:766799482
791 791 c, t dbSNP:200210453
794 794 a, g dbSNP:567036599
796 796 -, t dbSNP:751120699
806 806 c, g dbSNP:371686514
810 810 a, c dbSNP:202176021
822 822 c, t dbSNP:765464734
824 824 a, g dbSNP:200410369
827 827 a, g dbSNP:753009383
828 828 c, t dbSNP:144629723
829 829 a, g dbSNP:770238439
830 830 a, t dbSNP:751577358
832 832 g, t dbSNP:757273954
835 835 a, c dbSNP:767523385
845 845 c, t dbSNP:750266631
849 849 c, t dbSNP:756024386
858 858 a, g dbSNP:779684855
861 861 a, t dbSNP:749034384
864 864 a, c dbSNP:754571073
871 871 g, t dbSNP:201671829
873 873 a, c, t dbSNP:199760083
874 874 a, g dbSNP:200173519
879 879 a, g dbSNP:555809980
880 880 a, g, t dbSNP:574125890
882 882 g, t dbSNP:190477948
914 914 c, t dbSNP:763295042
915 915 g, t dbSNP:764165210
923 923 a, t dbSNP:63750880
930 930 c, g dbSNP:145010538
932 932 -, c dbSNP:754569211
932 932 a, g dbSNP:200754713
937 937 a, g dbSNP:201908554
939 939 c, g dbSNP:750424014
948 948 c, t dbSNP:61730652
950 950 c, t dbSNP:200670135
951 951 a, g dbSNP:202003390
952 952 c, t dbSNP:367855127
955 955 a, g dbSNP:28936379
957 957 a, g dbSNP:63749884
958 958 g, t dbSNP:778393774
965 965 c, t dbSNP:200133314
969 969 c, g dbSNP:371562367
972 972 c, t dbSNP:757955974
976 976 c, t dbSNP:777235854
979 979 c, t dbSNP:140562931
984 984 a, g dbSNP:145400391
993 993 c, t dbSNP:200332829
994 994 a, g dbSNP:138836272
995 995 c, g, t dbSNP:201403206
996 996 a, c, g dbSNP:147702142
1000 1000 a, g dbSNP:773410250
1003 1003 a, t dbSNP:201292728
1005 1005 c, t dbSNP:760698293
1009 1009 a, g dbSNP:766159571
1010 1010 g, t dbSNP:369429245
1011 1011 c, g, t dbSNP:7539017
1012 1012 a, g, t dbSNP:148238688
1021 1021 c, g dbSNP:201055590
1021 1021 -, g dbSNP:781053654
1023 1023 a, g dbSNP:202210060
1030 1030 c, t dbSNP:200694973
1032 1032 c, g, t dbSNP:77875620
1033 1033 a, g dbSNP:199707432
1038 1038 c, t dbSNP:200644982
1040 1040 g, t dbSNP:77421307
1041 1041 a, g dbSNP:780721688
1044 1044 c, g dbSNP:201606093
1054 1054 a, g dbSNP:755495216
1057 1057 a, c dbSNP:779431743
1071 1071 a, g dbSNP:748453717
1081 1081 g, t dbSNP:772451160
1094 1094 a, g dbSNP:150780392
1101 1101 c, t dbSNP:75733498
1112 1112 c, t dbSNP:374055800
1114 1114 c, g dbSNP:776770770
1117 1117 a, t dbSNP:199689738
1120 1120 c, t dbSNP:769715316
1124 1124 c, t dbSNP:200668817
1128 1128 c, t dbSNP:772626008
1141 1141 a, t dbSNP:760178182
1142 1142 c, t dbSNP:144277432
1143 1143 a, g, t dbSNP:6426553
1154 1154 a, c, t dbSNP:200501733
1155 1155 a, g dbSNP:75357954
1167 1167 c, t dbSNP:200326485
1168 1168 c, t dbSNP:781436525
1170 1170 c, g dbSNP:745958627
1177 1177 a, g dbSNP:756225509
1182 1182 c, g, t dbSNP:780103765
1187 1187 a, g dbSNP:201778576
1194 1194 c, t dbSNP:199587016
1196 1196 a, g dbSNP:547494670
1197 1197 c, t dbSNP:747932826
1198 1198 a, c, g dbSNP:565698726
1201 1201 c, g dbSNP:753390653
1205 1205 a, g dbSNP:760376643
1213 1213 g, t dbSNP:778824612
1223 1223 -, t dbSNP:765039787
1232 1232 c, t dbSNP:373934941
1233 1233 c, g, t dbSNP:200044441
1237 1237 c, g dbSNP:758259518
1240 1240 a, c, g dbSNP:777639021
1241 1241 c, g dbSNP:63750207
1245 1245 a, g, t dbSNP:781365270
1251 1251 c, t dbSNP:769386876
1252 1252 a, g dbSNP:559617407
1254 1254 a, g dbSNP:530065304
1255 1255 a, g dbSNP:201917728
1263 1263 a, g dbSNP:199881176
1264 1264 c, t dbSNP:773597667
1269 1269 c, t dbSNP:760977533
1281 1281 a, c dbSNP:766705508
1282 1282 c, g dbSNP:776874000
1285 1285 a, g dbSNP:759669954
1289 1289 a, g dbSNP:78420366
1292 1292 a, g dbSNP:765420103
1308 1308 a, g dbSNP:200977587
1309 1309 -, a dbSNP:773094480
1314 1314 a, g dbSNP:575912514
1316 1316 c, g dbSNP:779522932
1317 1317 c, g, t dbSNP:753503617
1318 1318 a, g dbSNP:563053551
1332 1332 c, t dbSNP:201093218
1335 1335 a, g dbSNP:771373304
1349 1349 a, c dbSNP:781543554
1361 1361 c, t dbSNP:746182253
1362 1362 a, g dbSNP:770080595
1368 1368 a, g dbSNP:539696910
1370 1370 c, t dbSNP:199714082
1371 1371 a, g dbSNP:377489312
1372 1372 c, g dbSNP:774513973
1374 1374 a, t dbSNP:761844882
1379 1379 a, c dbSNP:143912759
1380 1380 a, g dbSNP:377494557
1386 1386 -, g dbSNP:766393518
1386 1386 c, t dbSNP:760432548
1388 1388 a, g dbSNP:145671982
1389 1389 c, g dbSNP:201772526
1392 1392 c, g dbSNP:199550349
1393 1393 a, t dbSNP:753499090
1396 1396 a, c dbSNP:149172004
1403 1403 c, t dbSNP:143549266
1404 1404 a, c, g dbSNP:369274454
1407 1407 a, g dbSNP:781506963
1416 1416 c, t dbSNP:115652716
1417 1417 a, g dbSNP:142690225
1426 1426 c, t dbSNP:780464244
1428 1428 a, c dbSNP:749533069
1429 1429 a, c dbSNP:768931743
1440 1440 c, t dbSNP:138494303
1445 1445 c, t dbSNP:746930366
1448 1448 a, t dbSNP:770838733
1460 1460 a, c dbSNP:371315050
1469 1469 a, g dbSNP:759282140
1472 1472 a, g dbSNP:764998593
1475 1475 c, t dbSNP:775164469
1476 1476 a, g dbSNP:201982084
1480 1480 c, t dbSNP:200427880
1482 1482 c, t dbSNP:751025333
1483 1483 a, g dbSNP:201494033
1488 1488 c, t dbSNP:555914170
1492 1492 a, g dbSNP:199796978
1502 1502 c, t dbSNP:756609078
1503 1503 a, g, t dbSNP:766859560
1506 1506 c, g, t dbSNP:200169735
1509 1509 a, g dbSNP:748435174
1513 1513 a, g dbSNP:758586194
1515 1515 c, t dbSNP:777716175
1519 1519 c, t dbSNP:747074838
1524 1524 c, t dbSNP:144318314
1529 1529 c, t dbSNP:63750666
1533 1533 a, c dbSNP:776603544
1534 1534 a, c dbSNP:199676786
1539 1539 a, g dbSNP:769644784
1541 1541 g, t dbSNP:775252540
1543 1543 c, t dbSNP:142772982
1544 1544 a, g dbSNP:201922151
1545 1545 g, t dbSNP:773754382
1547 1547 a, c, t dbSNP:749755334
1548 1548 a, g dbSNP:199547508
1552 1552 a, g dbSNP:200804459
1553 1553 c, t dbSNP:750161150
1556 1556 a, c dbSNP:63750110
1557 1557 c, t dbSNP:201424233
1570 1570 c, t dbSNP:151048692
1578 1578 c, g dbSNP:758582618
1582 1582 a, g dbSNP:778005647
1590 1590 a, g, t dbSNP:200164062
1593 1593 a, g dbSNP:371693894
1605 1605 a, g dbSNP:200745703
1607 1607 a, g dbSNP:201399057
1613 1613 a, g dbSNP:769663194
1620 1620 a, g dbSNP:779830498
1631 1631 c, t dbSNP:200016565
1635 1635 a, g dbSNP:768312153
1639 1639 a, c dbSNP:774092766
1658 1658 a, c dbSNP:537889666
1660 1660 a, c dbSNP:550113178
1668 1668 a, g, t dbSNP:200943229
1681 1681 c, t dbSNP:202239448
1690 1690 c, t dbSNP:571670427
1707 1707 a, g dbSNP:143059995
1719 1719 c, t dbSNP:186288674
1729 1729 a, g dbSNP:201163703
1775 1775 c, t dbSNP:202067223
1777 1777 a, c dbSNP:200407641
1780 1780 a, c, g dbSNP:201559102
1792 1792 a, g dbSNP:199571588
1796 1796 c, t dbSNP:571949639
1797 1797 a, g dbSNP:200296479
1798 1798 c, g dbSNP:542892604
1803 1803 c, t dbSNP:201488196
1804 1804 a, g dbSNP:199791100
1804 1804 -, g dbSNP:144289421
1805 1805 g, t dbSNP:774892527
1825 1825 c, t dbSNP:200615414
1857 1857 c, t dbSNP:8383
1859 1859 a, g dbSNP:771604803
1871 1871 a, t dbSNP:199645229
1874 1874 a, g dbSNP:200641411
1877 1877 a, t dbSNP:201605500
1893 1893 a, g dbSNP:145129440
1895 1895 -, aa dbSNP:772387766
1899 1899 a, c dbSNP:200559114
1900 1900 a, g dbSNP:201773209
1907 1907 c, t dbSNP:200161165
1929 1929 g, t dbSNP:200923178
1938 1938 a, g dbSNP:202178096
1949 1949 a, g dbSNP:199949722
1963 1963 a, g dbSNP:201114015
1964 1964 c, t dbSNP:202160009
1965 1965 c, g dbSNP:200173939
1979 1979 a, g dbSNP:201510179
1992 1992 g, t dbSNP:116807339
2001 2001 a, g dbSNP:200536369
2028 2028 g, t dbSNP:201603449
2041 2041 a, t dbSNP:199579988
2042 2042 c, t dbSNP:200568747
2053 2053 c, t dbSNP:191115973
2056 2056 c, t dbSNP:541168117
2061 2061 a, g dbSNP:559491058
2066 2066 g, t dbSNP:201177570
2074 2074 c, g dbSNP:7962
2091 2091 a, g dbSNP:549584732
2093 2093 a, g dbSNP:561437447
2111 2111 a, g dbSNP:200610385

Target ORF information:

RefSeq Version XM_005273199
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005273199

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59977
Accession Version XM_011544236.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 915bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167186.2) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGATCAGCG TCATCGTGGT TATGACCATC TTCTTGGTGG TGCTCTACAA GTACCGCTGC 
TACAAGTTCA TCCATGGCTG GTTGATCATG TCTTCACTGA TGCTGCTGTT CCTCTTCACC
TATATCTACC TTGGGGAAGT GCTCAAGACC TACAATGTGG CCATGGACTA CCCCACCCTC
TTGCTGACTG TCTGGAACTT CGGGGCAGTG GGCATGGTGT GCATCCACTG GAAGGGCCCT
CTGGTGCTGC AGCAGGCCTA CCTCATCATG ATCAGTGCGC TCATGGCCCT AGTGTTCATC
AAGTACCTCC CAGAGTGGTC CGCGTGGGTC ATCCTGGGCG CCATCTCTGT GTATGATCTC
GTGGCTGTGC TGTGTCCCAA AGGGCCTCTG AGAATGCTGG TAGAAACTGC CCAGGAGAGA
AATGAGCCCA TATTCCCTGC CCTGATATAC TCATCTGCCA TGGTGTGGAC GGTTGGCATG
GCGAAGCTGG ACCCCTCCTC TCAGGGTGCC CTCCAGCTCC CCTACGACCC GGAGATGGAA
GAAGACTCCT ATGACAGTTT TGGGGAGCCT TCATACCCCG AAGTCTTTGA GCCTCCCTTG
ACTGGCTACC CAGGGGAGGA GCTGGAGGAA GAGGAGGAAA GGGGCGTGAA GCTTGGCCTC
GGGGACTTCA TCTTCTACAG TGTGCTGGTG GGCAAGGCGG CTGCCACGGG CAGCGGGGAC
TGGAATACCA CGCTGGCCTG CTTCGTGGCC ATCCTCATTG GCTTGTGTCT GACCCTCCTG
CTGCTTGCTG TGTTCAAGAA GGCGCTGCCC GCCCTCCCCA TCTCCATCAC GTTCGGGCTC
ATCTTTTACT TCTCCACGGA CAACCTGGTG CGGCCGTTCA TGGACACCCT GGCCTCCCAT
CAGCTCTACA TCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011542538.1
CDS406..1320
Misc Feature(1)406..1290(+)
Translation
Position Chain Variation Link
3 3 a, g dbSNP:553710955
12 12 a, g dbSNP:6665033
15 15 a, g, t dbSNP:201106517
18 18 a, g dbSNP:202060347
22 22 c, g dbSNP:542283623
46 46 a, t dbSNP:200232829
49 49 a, g dbSNP:201559176
52 52 a, g dbSNP:199762553
53 53 a, c dbSNP:191052430
54 54 c, t dbSNP:201515227
72 72 c, t dbSNP:199532840
74 74 c, t dbSNP:529406499
75 75 c, t dbSNP:1295645
76 76 c, g dbSNP:563084524
77 77 c, g dbSNP:766313511
92 92 a, t dbSNP:753800412
99 99 a, g dbSNP:201552337
103 103 a, g dbSNP:199696668
108 108 c, t dbSNP:145582210
130 130 c, t dbSNP:201316014
138 138 g, t dbSNP:200165480
144 144 c, t dbSNP:200954447
166 166 c, t dbSNP:149590162
186 186 a, g dbSNP:200591275
201 201 c, t dbSNP:201494032
211 211 c, t dbSNP:199632838
212 212 a, g dbSNP:200305467
218 218 a, g dbSNP:201300501
227 227 a, g dbSNP:112062360
229 229 c, t dbSNP:199803697
268 268 a, c, t dbSNP:200607063
275 275 a, g dbSNP:768399982
286 286 a, g dbSNP:570850485
293 293 c, t dbSNP:201111506
307 307 c, t dbSNP:7961
312 312 c, t dbSNP:200982557
313 313 a, g dbSNP:201820913
329 329 g, t dbSNP:200034334
337 337 a, c dbSNP:63749851
338 338 c, g, t dbSNP:28936380
339 339 a, g dbSNP:148996705
345 345 c, t dbSNP:753371172
348 348 c, t dbSNP:758985161
351 351 a, g dbSNP:547731225
355 355 a, g dbSNP:566361436
356 356 c, t dbSNP:752002301
362 362 c, t dbSNP:63750197
363 363 c, g dbSNP:781597971
372 372 c, g dbSNP:746117072
374 374 a, g, t dbSNP:756346917
383 383 a, g dbSNP:749301595
384 384 c, t dbSNP:200924879
387 387 c, t dbSNP:747738607
388 388 a, g, t dbSNP:202178897
391 391 c, t dbSNP:773059327
392 392 c, t dbSNP:760299337
394 394 a, t dbSNP:61761208
395 395 a, t dbSNP:63750215
396 396 c, t dbSNP:116003409
397 397 a, t dbSNP:201590095
402 402 c, t dbSNP:201196514
403 403 a, c dbSNP:764718172
412 412 a, g dbSNP:201892898
414 414 c, t dbSNP:114334281
415 415 a, g dbSNP:63750812
420 420 c, t dbSNP:767835970
428 428 c, t dbSNP:199654606
433 433 a, g dbSNP:139573101
440 440 g, t dbSNP:756296193
442 442 a, g, t dbSNP:780284265
455 455 a, g dbSNP:755101354
460 460 a, c dbSNP:200931244
461 461 a, g dbSNP:778936527
468 468 c, g dbSNP:748154107
478 478 a, c dbSNP:533813519
489 489 a, g dbSNP:745582651
493 493 a, g dbSNP:61757781
497 497 c, g dbSNP:775145486
501 501 a, g dbSNP:762485322
502 502 c, g dbSNP:772480664
510 510 a, g dbSNP:201896763
511 511 c, t dbSNP:773820169
513 513 a, g dbSNP:761057590
518 518 -, gg dbSNP:757877983
518 518 a, t dbSNP:766799482
524 524 c, t dbSNP:200210453
527 527 a, g dbSNP:567036599
529 529 -, t dbSNP:751120699
539 539 c, g dbSNP:371686514
543 543 a, c dbSNP:202176021
555 555 c, t dbSNP:765464734
557 557 a, g dbSNP:200410369
560 560 a, g dbSNP:753009383
561 561 c, t dbSNP:144629723
562 562 a, g dbSNP:770238439
563 563 a, t dbSNP:751577358
565 565 g, t dbSNP:757273954
568 568 a, c dbSNP:767523385
578 578 c, t dbSNP:750266631
582 582 c, t dbSNP:756024386
591 591 a, g dbSNP:779684855
594 594 a, t dbSNP:749034384
597 597 a, c dbSNP:754571073
604 604 g, t dbSNP:201671829
606 606 a, c, t dbSNP:199760083
607 607 a, g dbSNP:200173519
612 612 a, g dbSNP:555809980
613 613 a, g, t dbSNP:574125890
615 615 g, t dbSNP:190477948
647 647 c, t dbSNP:763295042
648 648 g, t dbSNP:764165210
656 656 a, t dbSNP:63750880
663 663 c, g dbSNP:145010538
665 665 -, c dbSNP:754569211
665 665 a, g dbSNP:200754713
670 670 a, g dbSNP:201908554
672 672 c, g dbSNP:750424014
681 681 c, t dbSNP:61730652
683 683 c, t dbSNP:200670135
684 684 a, g dbSNP:202003390
685 685 c, t dbSNP:367855127
688 688 a, g dbSNP:28936379
690 690 a, g dbSNP:63749884
691 691 g, t dbSNP:778393774
698 698 c, t dbSNP:200133314
702 702 c, g dbSNP:371562367
705 705 c, t dbSNP:757955974
709 709 c, t dbSNP:777235854
712 712 c, t dbSNP:140562931
717 717 a, g dbSNP:145400391
726 726 c, t dbSNP:200332829
727 727 a, g dbSNP:138836272
728 728 c, g, t dbSNP:201403206
729 729 a, c, g dbSNP:147702142
733 733 a, g dbSNP:773410250
736 736 a, t dbSNP:201292728
738 738 c, t dbSNP:760698293
742 742 a, g dbSNP:766159571
743 743 g, t dbSNP:369429245
744 744 c, g, t dbSNP:7539017
745 745 a, g, t dbSNP:148238688
754 754 c, g dbSNP:201055590
754 754 -, g dbSNP:781053654
756 756 a, g dbSNP:202210060
763 763 c, t dbSNP:200694973
765 765 c, g, t dbSNP:77875620
766 766 a, g dbSNP:199707432
771 771 c, t dbSNP:200644982
773 773 g, t dbSNP:77421307
774 774 a, g dbSNP:780721688
777 777 c, g dbSNP:201606093
787 787 a, g dbSNP:755495216
790 790 a, c dbSNP:779431743
804 804 a, g dbSNP:748453717
814 814 g, t dbSNP:772451160
827 827 a, g dbSNP:150780392
834 834 c, t dbSNP:75733498
845 845 c, t dbSNP:374055800
847 847 c, g dbSNP:776770770
850 850 a, t dbSNP:199689738
853 853 c, t dbSNP:769715316
857 857 c, t dbSNP:200668817
861 861 c, t dbSNP:772626008
874 874 a, t dbSNP:760178182
875 875 c, t dbSNP:144277432
876 876 a, g, t dbSNP:6426553
887 887 a, c, t dbSNP:200501733
888 888 a, g dbSNP:75357954
900 900 c, t dbSNP:200326485
901 901 c, t dbSNP:781436525
903 903 c, g dbSNP:745958627
910 910 a, g dbSNP:756225509
915 915 c, g, t dbSNP:780103765
920 920 a, g dbSNP:201778576
927 927 c, t dbSNP:199587016
929 929 a, g dbSNP:547494670
930 930 c, t dbSNP:747932826
931 931 a, c, g dbSNP:565698726
934 934 c, g dbSNP:753390653
938 938 a, g dbSNP:760376643
946 946 g, t dbSNP:778824612
956 956 -, t dbSNP:765039787
965 965 c, t dbSNP:373934941
966 966 c, g, t dbSNP:200044441
970 970 c, g dbSNP:758259518
973 973 a, c, g dbSNP:777639021
974 974 c, g dbSNP:63750207
978 978 a, g, t dbSNP:781365270
984 984 c, t dbSNP:769386876
985 985 a, g dbSNP:559617407
987 987 a, g dbSNP:530065304
988 988 a, g dbSNP:201917728
996 996 a, g dbSNP:199881176
997 997 c, t dbSNP:773597667
1002 1002 c, t dbSNP:760977533
1014 1014 a, c dbSNP:766705508
1015 1015 c, g dbSNP:776874000
1018 1018 a, g dbSNP:759669954
1022 1022 a, g dbSNP:78420366
1025 1025 a, g dbSNP:765420103
1041 1041 a, g dbSNP:200977587
1042 1042 -, a dbSNP:773094480
1047 1047 a, g dbSNP:575912514
1049 1049 c, g dbSNP:779522932
1050 1050 c, g, t dbSNP:753503617
1051 1051 a, g dbSNP:563053551
1065 1065 c, t dbSNP:201093218
1068 1068 a, g dbSNP:771373304
1082 1082 a, c dbSNP:781543554
1094 1094 c, t dbSNP:746182253
1095 1095 a, g dbSNP:770080595
1101 1101 a, g dbSNP:539696910
1103 1103 c, t dbSNP:199714082
1104 1104 a, g dbSNP:377489312
1105 1105 c, g dbSNP:774513973
1107 1107 a, t dbSNP:761844882
1112 1112 a, c dbSNP:143912759
1113 1113 a, g dbSNP:377494557
1119 1119 -, g dbSNP:766393518
1119 1119 c, t dbSNP:760432548
1121 1121 a, g dbSNP:145671982
1122 1122 c, g dbSNP:201772526
1125 1125 c, g dbSNP:199550349
1126 1126 a, t dbSNP:753499090
1129 1129 a, c dbSNP:149172004
1136 1136 c, t dbSNP:143549266
1137 1137 a, c, g dbSNP:369274454
1140 1140 a, g dbSNP:781506963
1149 1149 c, t dbSNP:115652716
1150 1150 a, g dbSNP:142690225
1159 1159 c, t dbSNP:780464244
1161 1161 a, c dbSNP:749533069
1162 1162 a, c dbSNP:768931743
1173 1173 c, t dbSNP:138494303
1178 1178 c, t dbSNP:746930366
1181 1181 a, t dbSNP:770838733
1193 1193 a, c dbSNP:371315050
1202 1202 a, g dbSNP:759282140
1205 1205 a, g dbSNP:764998593
1208 1208 c, t dbSNP:775164469
1209 1209 a, g dbSNP:201982084
1213 1213 c, t dbSNP:200427880
1215 1215 c, t dbSNP:751025333
1216 1216 a, g dbSNP:201494033
1221 1221 c, t dbSNP:555914170
1225 1225 a, g dbSNP:199796978
1235 1235 c, t dbSNP:756609078
1236 1236 a, g, t dbSNP:766859560
1239 1239 c, g, t dbSNP:200169735
1242 1242 a, g dbSNP:748435174
1246 1246 a, g dbSNP:758586194
1248 1248 c, t dbSNP:777716175
1252 1252 c, t dbSNP:747074838
1257 1257 c, t dbSNP:144318314
1262 1262 c, t dbSNP:63750666
1266 1266 a, c dbSNP:776603544
1267 1267 a, c dbSNP:199676786
1272 1272 a, g dbSNP:769644784
1274 1274 g, t dbSNP:775252540
1276 1276 c, t dbSNP:142772982
1277 1277 a, g dbSNP:201922151
1278 1278 g, t dbSNP:773754382
1280 1280 a, c, t dbSNP:749755334
1281 1281 a, g dbSNP:199547508
1285 1285 a, g dbSNP:200804459
1286 1286 c, t dbSNP:750161150
1289 1289 a, c dbSNP:63750110
1290 1290 c, t dbSNP:201424233
1303 1303 c, t dbSNP:151048692
1311 1311 c, g dbSNP:758582618
1315 1315 a, g dbSNP:778005647
1323 1323 a, g, t dbSNP:200164062
1326 1326 a, g dbSNP:371693894
1338 1338 a, g dbSNP:200745703
1340 1340 a, g dbSNP:201399057
1346 1346 a, g dbSNP:769663194
1353 1353 a, g dbSNP:779830498
1364 1364 c, t dbSNP:200016565
1368 1368 a, g dbSNP:768312153
1372 1372 a, c dbSNP:774092766
1391 1391 a, c dbSNP:537889666
1393 1393 a, c dbSNP:550113178
1401 1401 a, g, t dbSNP:200943229
1414 1414 c, t dbSNP:202239448
1423 1423 c, t dbSNP:571670427
1440 1440 a, g dbSNP:143059995
1452 1452 c, t dbSNP:186288674
1462 1462 a, g dbSNP:201163703
1508 1508 c, t dbSNP:202067223
1510 1510 a, c dbSNP:200407641
1513 1513 a, c, g dbSNP:201559102
1525 1525 a, g dbSNP:199571588
1529 1529 c, t dbSNP:571949639
1530 1530 a, g dbSNP:200296479
1531 1531 c, g dbSNP:542892604
1536 1536 c, t dbSNP:201488196
1537 1537 a, g dbSNP:199791100
1537 1537 -, g dbSNP:144289421
1538 1538 g, t dbSNP:774892527
1558 1558 c, t dbSNP:200615414
1590 1590 c, t dbSNP:8383
1592 1592 a, g dbSNP:771604803
1604 1604 a, t dbSNP:199645229
1607 1607 a, g dbSNP:200641411
1610 1610 a, t dbSNP:201605500
1626 1626 a, g dbSNP:145129440
1628 1628 -, aa dbSNP:772387766
1632 1632 a, c dbSNP:200559114
1633 1633 a, g dbSNP:201773209
1640 1640 c, t dbSNP:200161165
1662 1662 g, t dbSNP:200923178
1671 1671 a, g dbSNP:202178096
1682 1682 a, g dbSNP:199949722
1696 1696 a, g dbSNP:201114015
1697 1697 c, t dbSNP:202160009
1698 1698 c, g dbSNP:200173939
1712 1712 a, g dbSNP:201510179
1725 1725 g, t dbSNP:116807339
1734 1734 a, g dbSNP:200536369
1761 1761 g, t dbSNP:201603449
1774 1774 a, t dbSNP:199579988
1775 1775 c, t dbSNP:200568747
1786 1786 c, t dbSNP:191115973
1789 1789 c, t dbSNP:541168117
1794 1794 a, g dbSNP:559491058
1799 1799 g, t dbSNP:201177570
1807 1807 c, g dbSNP:7962
1824 1824 a, g dbSNP:549584732
1826 1826 a, g dbSNP:561437447
1844 1844 a, g dbSNP:200610385

Target ORF information:

RefSeq Version XM_011544236
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens presenilin 2 (PSEN2), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011544236

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGATCAGCG TCATCGTGGT TATGACCATC TTCTTGGTGG TGCTCTACAA GTACCGCTGC 
TACAAGTTCA TCCATGGCTG GTTGATCATG TCTTCACTGA TGCTGCTGTT CCTCTTCACC
TATATCTACC TTGGGGAAGT GCTCAAGACC TACAATGTGG CCATGGACTA CCCCACCCTC
TTGCTGACTG TCTGGAACTT CGGGGCAGTG GGCATGGTGT GCATCCACTG GAAGGGCCCT
CTGGTGCTGC AGCAGGCCTA CCTCATCATG ATCAGTGCGC TCATGGCCCT AGTGTTCATC
AAGTACCTCC CAGAGTGGTC CGCGTGGGTC ATCCTGGGCG CCATCTCTGT GTATGATCTC
GTGGCTGTGC TGTGTCCCAA AGGGCCTCTG AGAATGCTGG TAGAAACTGC CCAGGAGAGA
AATGAGCCCA TATTCCCTGC CCTGATATAC TCATCTGCCA TGGTGTGGAC GGTTGGCATG
GCGAAGCTGG ACCCCTCCTC TCAGGGTGCC CTCCAGCTCC CCTACGACCC GGAGATGGAA
GAAGACTCCT ATGACAGTTT TGGGGAGCCT TCATACCCCG AAGTCTTTGA GCCTCCCTTG
ACTGGCTACC CAGGGGAGGA GCTGGAGGAA GAGGAGGAAA GGGGCGTGAA GCTTGGCCTC
GGGGACTTCA TCTTCTACAG TGTGCTGGTG GGCAAGGCGG CTGCCACGGG CAGCGGGGAC
TGGAATACCA CGCTGGCCTG CTTCGTGGCC ATCCTCATTG GCTTGTGTCT GACCCTCCTG
CTGCTTGCTG TGTTCAAGAA GGCGCTGCCC GCCCTCCCCA TCTCCATCAC GTTCGGGCTC
ATCTTTTACT TCTCCACGGA CAACCTGGTG CGGCCGTTCA TGGACACCCT GGCCTCCCAT
CAGCTCTACA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24950
Accession Version NM_000447.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1347bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, BT006984.1, L43964.1 and AI091221.1. This sequence is a reference standard in the RefSeqGene project. On Aug 17, 2007 this sequence version replaced gi:4506164. Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L43964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000438.2
CDS428..1774
Misc Feature(1)341..343(+)
Misc Feature(2)491..493(+)
Misc Feature(3)500..502(+)
Misc Feature(4)653..1744(+)
Misc Feature(5)689..751(+)
Misc Feature(6)842..904(+)
Misc Feature(7)926..988(+)
Misc Feature(8)1028..1090(+)
Misc Feature(9)1097..1159(+)
Misc Feature(10)1175..1237(+)
Misc Feature(11)1511..1573(+)
Misc Feature(12)1592..1654(+)
Misc Feature(13)1667..1675(+)
Exon (1)1..78
Gene:PSEN2
Gene Synonym:
Exon (2)79..221
Gene:PSEN2
Gene Synonym:
Exon (3)222..407
Gene:PSEN2
Gene Synonym:
Exon (4)408..568
Gene:PSEN2
Gene Synonym:
Exon (5)569..783
Gene:PSEN2
Gene Synonym:
Exon (6)784..925
Gene:PSEN2
Gene Synonym:
Exon (7)926..993
Gene:PSEN2
Gene Synonym:
Exon (8)994..1214
Gene:PSEN2
Gene Synonym:
Exon (9)1215..1313
Gene:PSEN2
Gene Synonym:
Exon (10)1314..1397
Gene:PSEN2
Gene Synonym:
Exon (11)1398..1499
Gene:PSEN2
Gene Synonym:
Exon (12)1500..1618
Gene:PSEN2
Gene Synonym:
Exon (13)1619..2298
Gene:PSEN2
Gene Synonym:
Translation
Position Chain Variation Link
23 23 c, t dbSNP:764838007
28 28 c, t dbSNP:186308126
29 29 a, g dbSNP:545100918
46 46 c, t dbSNP:559946328
72 72 a, g dbSNP:12758915
81 81 a, g dbSNP:553710955
90 90 a, g dbSNP:6665033
93 93 a, g, t dbSNP:201106517
96 96 a, g dbSNP:202060347
100 100 c, g dbSNP:542283623
124 124 a, t dbSNP:200232829
127 127 a, g dbSNP:201559176
130 130 a, g dbSNP:199762553
131 131 a, c dbSNP:191052430
132 132 c, t dbSNP:201515227
150 150 c, t dbSNP:199532840
152 152 c, t dbSNP:529406499
153 153 c, t dbSNP:1295645
154 154 c, g dbSNP:563084524
155 155 c, g dbSNP:766313511
170 170 a, t dbSNP:753800412
177 177 a, g dbSNP:201552337
181 181 a, g dbSNP:199696668
186 186 c, t dbSNP:145582210
208 208 c, t dbSNP:201316014
216 216 g, t dbSNP:200165480
222 222 c, t dbSNP:200954447
244 244 c, t dbSNP:149590162
264 264 a, g dbSNP:200591275
279 279 c, t dbSNP:201494032
289 289 c, t dbSNP:199632838
290 290 a, g dbSNP:200305467
296 296 a, g dbSNP:201300501
305 305 a, g dbSNP:112062360
307 307 c, t dbSNP:199803697
346 346 a, c, t dbSNP:200607063
353 353 a, g dbSNP:768399982
364 364 a, g dbSNP:570850485
371 371 c, t dbSNP:201111506
385 385 c, t dbSNP:7961
390 390 c, t dbSNP:200982557
391 391 a, g dbSNP:201820913
407 407 g, t dbSNP:200034334
415 415 c, t dbSNP:745616954
424 424 a, g dbSNP:769574014
426 426 c, t dbSNP:775235673
429 429 c, t dbSNP:762674312
431 431 c, g dbSNP:199739625
445 445 c, t dbSNP:763738488
452 452 a, g dbSNP:786205285
453 453 a, g dbSNP:200878942
454 454 c, t dbSNP:201692678
463 463 a, t dbSNP:761147472
465 465 g, t dbSNP:766853710
476 476 c, t dbSNP:199644116
480 480 c, t dbSNP:143061887
481 481 a, g dbSNP:201018913
490 490 c, g dbSNP:752960820
492 492 c, t dbSNP:552406611
493 493 a, g dbSNP:367645069
496 496 c, t dbSNP:11405
497 497 a, g dbSNP:757152552
504 504 c, t dbSNP:781116134
506 506 a, g dbSNP:147326133
507 507 c, t dbSNP:149354305
508 508 a, g dbSNP:144696679
509 509 a, c dbSNP:749015914
510 510 c, g, t dbSNP:748504448
511 511 a, g dbSNP:371475270
512 512 c, t dbSNP:142892469
513 513 a, g dbSNP:771375988
516 516 c, t dbSNP:200037771
521 521 c, g dbSNP:760011841
527 527 a, g dbSNP:200636353
538 538 c, t dbSNP:139309459
556 556 c, t dbSNP:6759
557 557 a, g dbSNP:200535276
559 559 a, t dbSNP:143227762
561 561 c, t dbSNP:751593722
563 563 c, t dbSNP:757319285
576 576 a, g dbSNP:143501870
581 581 a, g dbSNP:775935657
583 583 c, t dbSNP:749675208
589 589 c, g dbSNP:146894466
592 592 c, t dbSNP:139332886
593 593 a, g dbSNP:188598190
604 604 c, t dbSNP:767577993
610 610 c, t dbSNP:201261403
611 611 c, t dbSNP:150400387
612 612 a, g dbSNP:58973334
619 619 c, t dbSNP:201272715
621 621 a, g dbSNP:766446160
623 623 a, t dbSNP:753871802
624 624 a, g dbSNP:754836755
630 630 c, t dbSNP:765144719
632 632 a, c, g, t dbSNP:202133351
632 632 -, c dbSNP:746664513
633 633 c, g dbSNP:199968912
634 634 c, t dbSNP:142546082
635 635 a, g dbSNP:139972151
638 638 c, t dbSNP:140501902
639 639 a, g, t dbSNP:769031756
642 642 c, t dbSNP:369622085
645 645 c, g dbSNP:748397935
646 646 a, t dbSNP:772372158
649 649 c, g dbSNP:773522773
663 663 c, t dbSNP:760961297
676 676 c, t dbSNP:549378958
678 678 a, g dbSNP:776842226
681 681 c, t dbSNP:63750048
682 682 a, g dbSNP:765023751
688 688 c, t dbSNP:1046240
689 689 c, g dbSNP:758086169
706 706 c, g dbSNP:200350640
715 715 c, t dbSNP:751261061
719 719 c, t dbSNP:756899463
720 720 a, g dbSNP:780738564
721 721 c, t dbSNP:146718524
723 723 c, t dbSNP:755514702
727 727 c, t dbSNP:200801915
728 728 a, g dbSNP:373392465
733 733 a, g dbSNP:748572509
742 742 c, t dbSNP:553495122
750 750 c, g dbSNP:778247625
755 755 c, t dbSNP:199808788
756 756 a, g, t dbSNP:747296921
763 763 c, t dbSNP:200610057
775 775 c, t dbSNP:201119121
791 791 a, c dbSNP:63749851
792 792 c, g, t dbSNP:28936380
793 793 a, g dbSNP:148996705
799 799 c, t dbSNP:753371172
802 802 c, t dbSNP:758985161
805 805 a, g dbSNP:547731225
809 809 a, g dbSNP:566361436
810 810 c, t dbSNP:752002301
816 816 c, t dbSNP:63750197
817 817 c, g dbSNP:781597971
826 826 c, g dbSNP:746117072
828 828 a, g, t dbSNP:756346917
837 837 a, g dbSNP:749301595
838 838 c, t dbSNP:200924879
841 841 c, t dbSNP:747738607
842 842 a, g, t dbSNP:202178897
845 845 c, t dbSNP:773059327
846 846 c, t dbSNP:760299337
848 848 a, t dbSNP:61761208
849 849 a, t dbSNP:63750215
850 850 c, t dbSNP:116003409
851 851 a, t dbSNP:201590095
856 856 c, t dbSNP:201196514
857 857 a, c dbSNP:764718172
866 866 a, g dbSNP:201892898
868 868 c, t dbSNP:114334281
869 869 a, g dbSNP:63750812
874 874 c, t dbSNP:767835970
882 882 c, t dbSNP:199654606
887 887 a, g dbSNP:139573101
894 894 g, t dbSNP:756296193
896 896 a, g, t dbSNP:780284265
909 909 a, g dbSNP:755101354
914 914 a, c dbSNP:200931244
915 915 a, g dbSNP:778936527
922 922 c, g dbSNP:748154107
932 932 a, c dbSNP:533813519
943 943 a, g dbSNP:745582651
947 947 a, g dbSNP:61757781
951 951 c, g dbSNP:775145486
955 955 a, g dbSNP:762485322
956 956 c, g dbSNP:772480664
964 964 a, g dbSNP:201896763
965 965 c, t dbSNP:773820169
967 967 a, g dbSNP:761057590
972 972 -, gg dbSNP:757877983
972 972 a, t dbSNP:766799482
978 978 c, t dbSNP:200210453
981 981 a, g dbSNP:567036599
983 983 -, t dbSNP:751120699
993 993 c, g dbSNP:371686514
997 997 a, c dbSNP:202176021
1009 1009 c, t dbSNP:765464734
1011 1011 a, g dbSNP:200410369
1014 1014 a, g dbSNP:753009383
1015 1015 c, t dbSNP:144629723
1016 1016 a, g dbSNP:770238439
1017 1017 a, t dbSNP:751577358
1019 1019 g, t dbSNP:757273954
1022 1022 a, c dbSNP:767523385
1032 1032 c, t dbSNP:750266631
1036 1036 c, t dbSNP:756024386
1045 1045 a, g dbSNP:779684855
1048 1048 a, t dbSNP:749034384
1051 1051 a, c dbSNP:754571073
1058 1058 g, t dbSNP:201671829
1060 1060 a, c, t dbSNP:199760083
1061 1061 a, g dbSNP:200173519
1066 1066 a, g dbSNP:555809980
1067 1067 a, g, t dbSNP:574125890
1069 1069 g, t dbSNP:190477948
1101 1101 c, t dbSNP:763295042
1102 1102 g, t dbSNP:764165210
1110 1110 a, t dbSNP:63750880
1117 1117 c, g dbSNP:145010538
1119 1119 -, c dbSNP:754569211
1119 1119 a, g dbSNP:200754713
1124 1124 a, g dbSNP:201908554
1126 1126 c, g dbSNP:750424014
1135 1135 c, t dbSNP:61730652
1137 1137 c, t dbSNP:200670135
1138 1138 a, g dbSNP:202003390
1139 1139 c, t dbSNP:367855127
1142 1142 a, g dbSNP:28936379
1144 1144 a, g dbSNP:63749884
1145 1145 g, t dbSNP:778393774
1152 1152 c, t dbSNP:200133314
1156 1156 c, g dbSNP:371562367
1159 1159 c, t dbSNP:757955974
1163 1163 c, t dbSNP:777235854
1166 1166 c, t dbSNP:140562931
1171 1171 a, g dbSNP:145400391
1180 1180 c, t dbSNP:200332829
1181 1181 a, g dbSNP:138836272
1182 1182 c, g, t dbSNP:201403206
1183 1183 a, c, g dbSNP:147702142
1187 1187 a, g dbSNP:773410250
1190 1190 a, t dbSNP:201292728
1192 1192 c, t dbSNP:760698293
1196 1196 a, g dbSNP:766159571
1197 1197 g, t dbSNP:369429245
1198 1198 c, g, t dbSNP:7539017
1199 1199 a, g, t dbSNP:148238688
1208 1208 c, g dbSNP:201055590
1208 1208 -, g dbSNP:781053654
1210 1210 a, g dbSNP:202210060
1217 1217 c, t dbSNP:200694973
1219 1219 c, g, t dbSNP:77875620
1220 1220 a, g dbSNP:199707432
1225 1225 c, t dbSNP:200644982
1227 1227 g, t dbSNP:77421307
1228 1228 a, g dbSNP:780721688
1231 1231 c, g dbSNP:201606093
1241 1241 a, g dbSNP:755495216
1244 1244 a, c dbSNP:779431743
1258 1258 a, g dbSNP:748453717
1268 1268 g, t dbSNP:772451160
1281 1281 a, g dbSNP:150780392
1288 1288 c, t dbSNP:75733498
1299 1299 c, t dbSNP:374055800
1301 1301 c, g dbSNP:776770770
1304 1304 a, t dbSNP:199689738
1307 1307 c, t dbSNP:769715316
1311 1311 c, t dbSNP:200668817
1315 1315 c, t dbSNP:772626008
1328 1328 a, t dbSNP:760178182
1329 1329 c, t dbSNP:144277432
1330 1330 a, g, t dbSNP:6426553
1341 1341 a, c, t dbSNP:200501733
1342 1342 a, g dbSNP:75357954
1354 1354 c, t dbSNP:200326485
1355 1355 c, t dbSNP:781436525
1357 1357 c, g dbSNP:745958627
1364 1364 a, g dbSNP:756225509
1369 1369 c, g, t dbSNP:780103765
1374 1374 a, g dbSNP:201778576
1381 1381 c, t dbSNP:199587016
1383 1383 a, g dbSNP:547494670
1384 1384 c, t dbSNP:747932826
1385 1385 a, c, g dbSNP:565698726
1388 1388 c, g dbSNP:753390653
1392 1392 a, g dbSNP:760376643
1400 1400 g, t dbSNP:778824612
1410 1410 -, t dbSNP:765039787
1419 1419 c, t dbSNP:373934941
1420 1420 c, g, t dbSNP:200044441
1424 1424 c, g dbSNP:758259518
1427 1427 a, c, g dbSNP:777639021
1428 1428 c, g dbSNP:63750207
1432 1432 a, g, t dbSNP:781365270
1438 1438 c, t dbSNP:769386876
1439 1439 a, g dbSNP:559617407
1441 1441 a, g dbSNP:530065304
1442 1442 a, g dbSNP:201917728
1450 1450 a, g dbSNP:199881176
1451 1451 c, t dbSNP:773597667
1456 1456 c, t dbSNP:760977533
1468 1468 a, c dbSNP:766705508
1469 1469 c, g dbSNP:776874000
1472 1472 a, g dbSNP:759669954
1476 1476 a, g dbSNP:78420366
1479 1479 a, g dbSNP:765420103
1495 1495 a, g dbSNP:200977587
1496 1496 -, a dbSNP:773094480
1501 1501 a, g dbSNP:575912514
1503 1503 c, g dbSNP:779522932
1504 1504 c, g, t dbSNP:753503617
1505 1505 a, g dbSNP:563053551
1519 1519 c, t dbSNP:201093218
1522 1522 a, g dbSNP:771373304
1536 1536 a, c dbSNP:781543554
1548 1548 c, t dbSNP:746182253
1549 1549 a, g dbSNP:770080595
1555 1555 a, g dbSNP:539696910
1557 1557 c, t dbSNP:199714082
1558 1558 a, g dbSNP:377489312
1559 1559 c, g dbSNP:774513973
1561 1561 a, t dbSNP:761844882
1566 1566 a, c dbSNP:143912759
1567 1567 a, g dbSNP:377494557
1573 1573 -, g dbSNP:766393518
1573 1573 c, t dbSNP:760432548
1575 1575 a, g dbSNP:145671982
1576 1576 c, g dbSNP:201772526
1579 1579 c, g dbSNP:199550349
1580 1580 a, t dbSNP:753499090
1583 1583 a, c dbSNP:149172004
1590 1590 c, t dbSNP:143549266
1591 1591 a, c, g dbSNP:369274454
1594 1594 a, g dbSNP:781506963
1603 1603 c, t dbSNP:115652716
1604 1604 a, g dbSNP:142690225
1613 1613 c, t dbSNP:780464244
1615 1615 a, c dbSNP:749533069
1616 1616 a, c dbSNP:768931743
1627 1627 c, t dbSNP:138494303
1632 1632 c, t dbSNP:746930366
1635 1635 a, t dbSNP:770838733
1647 1647 a, c dbSNP:371315050
1656 1656 a, g dbSNP:759282140
1659 1659 a, g dbSNP:764998593
1662 1662 c, t dbSNP:775164469
1663 1663 a, g dbSNP:201982084
1667 1667 c, t dbSNP:200427880
1669 1669 c, t dbSNP:751025333
1670 1670 a, g dbSNP:201494033
1675 1675 c, t dbSNP:555914170
1679 1679 a, g dbSNP:199796978
1689 1689 c, t dbSNP:756609078
1690 1690 a, g, t dbSNP:766859560
1693 1693 c, g, t dbSNP:200169735
1696 1696 a, g dbSNP:748435174
1700 1700 a, g dbSNP:758586194
1702 1702 c, t dbSNP:777716175
1706 1706 c, t dbSNP:747074838
1711 1711 c, t dbSNP:144318314
1716 1716 c, t dbSNP:63750666
1720 1720 a, c dbSNP:776603544
1721 1721 a, c dbSNP:199676786
1726 1726 a, g dbSNP:769644784
1728 1728 g, t dbSNP:775252540
1730 1730 c, t dbSNP:142772982
1731 1731 a, g dbSNP:201922151
1732 1732 g, t dbSNP:773754382
1734 1734 a, c, t dbSNP:749755334
1735 1735 a, g dbSNP:199547508
1739 1739 a, g dbSNP:200804459
1740 1740 c, t dbSNP:750161150
1743 1743 a, c dbSNP:63750110
1744 1744 c, t dbSNP:201424233
1757 1757 c, t dbSNP:151048692
1765 1765 c, g dbSNP:758582618
1769 1769 a, g dbSNP:778005647
1777 1777 a, g, t dbSNP:200164062
1780 1780 a, g dbSNP:371693894
1792 1792 a, g dbSNP:200745703
1794 1794 a, g dbSNP:201399057
1800 1800 a, g dbSNP:769663194
1807 1807 a, g dbSNP:779830498
1818 1818 c, t dbSNP:200016565
1822 1822 a, g dbSNP:768312153
1826 1826 a, c dbSNP:774092766
1845 1845 a, c dbSNP:537889666
1847 1847 a, c dbSNP:550113178
1855 1855 a, g, t dbSNP:200943229
1868 1868 c, t dbSNP:202239448
1877 1877 c, t dbSNP:571670427
1894 1894 a, g dbSNP:143059995
1906 1906 c, t dbSNP:186288674
1916 1916 a, g dbSNP:201163703
1962 1962 c, t dbSNP:202067223
1964 1964 a, c dbSNP:200407641
1967 1967 a, c, g dbSNP:201559102
1979 1979 a, g dbSNP:199571588
1983 1983 c, t dbSNP:571949639
1984 1984 a, g dbSNP:200296479
1985 1985 c, g dbSNP:542892604
1990 1990 c, t dbSNP:201488196
1991 1991 a, g dbSNP:199791100
1991 1991 -, g dbSNP:144289421
1992 1992 g, t dbSNP:774892527
2012 2012 c, t dbSNP:200615414
2044 2044 c, t dbSNP:8383
2046 2046 a, g dbSNP:771604803
2058 2058 a, t dbSNP:199645229
2061 2061 a, g dbSNP:200641411
2064 2064 a, t dbSNP:201605500
2080 2080 a, g dbSNP:145129440
2082 2082 -, aa dbSNP:772387766
2086 2086 a, c dbSNP:200559114
2087 2087 a, g dbSNP:201773209
2094 2094 c, t dbSNP:200161165
2116 2116 g, t dbSNP:200923178
2125 2125 a, g dbSNP:202178096
2136 2136 a, g dbSNP:199949722
2150 2150 a, g dbSNP:201114015
2151 2151 c, t dbSNP:202160009
2152 2152 c, g dbSNP:200173939
2166 2166 a, g dbSNP:201510179
2179 2179 g, t dbSNP:116807339
2188 2188 a, g dbSNP:200536369
2215 2215 g, t dbSNP:201603449
2228 2228 a, t dbSNP:199579988
2229 2229 c, t dbSNP:200568747
2240 2240 c, t dbSNP:191115973
2243 2243 c, t dbSNP:541168117
2248 2248 a, g dbSNP:559491058
2253 2253 g, t dbSNP:201177570
2261 2261 c, g dbSNP:7962
2278 2278 a, g dbSNP:549584732
2280 2280 a, g dbSNP:561437447
2298 2298 a, g dbSNP:200610385

Target ORF information:

RefSeq Version NM_000447
Organism Homo sapiens (human)
Definition Homo sapiens presenilin 2 (PSEN2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000447

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGAAGACTC CTATGACAGT TTTGGGGAGC CTTCATACCC CGAAGTCTTT
GAGCCTCCCT TGACTGGCTA CCCAGGGGAG GAGCTGGAGG AAGAGGAGGA AAGGGGCGTG
AAGCTTGGCC TCGGGGACTT CATCTTCTAC AGTGTGCTGG TGGGCAAGGC GGCTGCCACG
GGCAGCGGGG ACTGGAATAC CACGCTGGCC TGCTTCGTGG CCATCCTCAT TGGCTTGTGT
CTGACCCTCC TGCTGCTTGC TGTGTTCAAG AAGGCGCTGC CCGCCCTCCC CATCTCCATC
ACGTTCGGGC TCATCTTTTA CTTCTCCACG GACAACCTGG TGCGGCCGTT CATGGACACC
CTGGCCTCCC ATCAGCTCTA CATCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24919
Accession Version NM_012486.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1344bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product presenilin-2 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA198818.1, DA915823.1, U34349.1, L43964.1 and AI091221.1. On Aug 17, 2007 this sequence version replaced gi:7108359. Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses an alternate splice acceptor site at exon 10 compared to transcript variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292299.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG
GCCTCCCATC AGCTCTACAT CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_036618.2
CDS428..1771
Misc Feature(1)341..343(+)
Misc Feature(2)491..493(+)
Misc Feature(3)500..502(+)
Misc Feature(4)653..1741(+)
Misc Feature(5)689..751(+)
Misc Feature(6)842..904(+)
Misc Feature(7)926..988(+)
Misc Feature(8)1028..1090(+)
Misc Feature(9)1097..1159(+)
Misc Feature(10)1175..1237(+)
Misc Feature(11)1508..1570(+)
Misc Feature(12)1589..1651(+)
Misc Feature(13)1664..1672(+)
Exon (1)1..78
Gene:PSEN2
Gene Synonym:
Exon (2)79..221
Gene:PSEN2
Gene Synonym:
Exon (3)222..407
Gene:PSEN2
Gene Synonym:
Exon (4)408..568
Gene:PSEN2
Gene Synonym:
Exon (5)569..783
Gene:PSEN2
Gene Synonym:
Exon (6)784..925
Gene:PSEN2
Gene Synonym:
Exon (7)926..993
Gene:PSEN2
Gene Synonym:
Exon (8)994..1214
Gene:PSEN2
Gene Synonym:
Exon (9)1215..1313
Gene:PSEN2
Gene Synonym:
Exon (10)1314..1397
Gene:PSEN2
Gene Synonym:
Exon (11)1398..1496
Gene:PSEN2
Gene Synonym:
Exon (12)1497..1615
Gene:PSEN2
Gene Synonym:
Exon (13)1616..2295
Gene:PSEN2
Gene Synonym:
Translation
Position Chain Variation Link
23 23 c, t dbSNP:764838007
28 28 c, t dbSNP:186308126
29 29 a, g dbSNP:545100918
46 46 c, t dbSNP:559946328
72 72 a, g dbSNP:12758915
81 81 a, g dbSNP:553710955
90 90 a, g dbSNP:6665033
93 93 a, g, t dbSNP:201106517
96 96 a, g dbSNP:202060347
100 100 c, g dbSNP:542283623
124 124 a, t dbSNP:200232829
127 127 a, g dbSNP:201559176
130 130 a, g dbSNP:199762553
131 131 a, c dbSNP:191052430
132 132 c, t dbSNP:201515227
150 150 c, t dbSNP:199532840
152 152 c, t dbSNP:529406499
153 153 c, t dbSNP:1295645
154 154 c, g dbSNP:563084524
155 155 c, g dbSNP:766313511
170 170 a, t dbSNP:753800412
177 177 a, g dbSNP:201552337
181 181 a, g dbSNP:199696668
186 186 c, t dbSNP:145582210
208 208 c, t dbSNP:201316014
216 216 g, t dbSNP:200165480
222 222 c, t dbSNP:200954447
244 244 c, t dbSNP:149590162
264 264 a, g dbSNP:200591275
279 279 c, t dbSNP:201494032
289 289 c, t dbSNP:199632838
290 290 a, g dbSNP:200305467
296 296 a, g dbSNP:201300501
305 305 a, g dbSNP:112062360
307 307 c, t dbSNP:199803697
346 346 a, c, t dbSNP:200607063
353 353 a, g dbSNP:768399982
364 364 a, g dbSNP:570850485
371 371 c, t dbSNP:201111506
385 385 c, t dbSNP:7961
390 390 c, t dbSNP:200982557
391 391 a, g dbSNP:201820913
407 407 g, t dbSNP:200034334
415 415 c, t dbSNP:745616954
424 424 a, g dbSNP:769574014
426 426 c, t dbSNP:775235673
429 429 c, t dbSNP:762674312
431 431 c, g dbSNP:199739625
445 445 c, t dbSNP:763738488
452 452 a, g dbSNP:786205285
453 453 a, g dbSNP:200878942
454 454 c, t dbSNP:201692678
463 463 a, t dbSNP:761147472
465 465 g, t dbSNP:766853710
476 476 c, t dbSNP:199644116
480 480 c, t dbSNP:143061887
481 481 a, g dbSNP:201018913
490 490 c, g dbSNP:752960820
492 492 c, t dbSNP:552406611
493 493 a, g dbSNP:367645069
496 496 c, t dbSNP:11405
497 497 a, g dbSNP:757152552
504 504 c, t dbSNP:781116134
506 506 a, g dbSNP:147326133
507 507 c, t dbSNP:149354305
508 508 a, g dbSNP:144696679
509 509 a, c dbSNP:749015914
510 510 c, g, t dbSNP:748504448
511 511 a, g dbSNP:371475270
512 512 c, t dbSNP:142892469
513 513 a, g dbSNP:771375988
516 516 c, t dbSNP:200037771
521 521 c, g dbSNP:760011841
527 527 a, g dbSNP:200636353
538 538 c, t dbSNP:139309459
556 556 c, t dbSNP:6759
557 557 a, g dbSNP:200535276
559 559 a, t dbSNP:143227762
561 561 c, t dbSNP:751593722
563 563 c, t dbSNP:757319285
576 576 a, g dbSNP:143501870
581 581 a, g dbSNP:775935657
583 583 c, t dbSNP:749675208
589 589 c, g dbSNP:146894466
592 592 c, t dbSNP:139332886
593 593 a, g dbSNP:188598190
604 604 c, t dbSNP:767577993
610 610 c, t dbSNP:201261403
611 611 c, t dbSNP:150400387
612 612 a, g dbSNP:58973334
619 619 c, t dbSNP:201272715
621 621 a, g dbSNP:766446160
623 623 a, t dbSNP:753871802
624 624 a, g dbSNP:754836755
630 630 c, t dbSNP:765144719
632 632 a, c, g, t dbSNP:202133351
632 632 -, c dbSNP:746664513
633 633 c, g dbSNP:199968912
634 634 c, t dbSNP:142546082
635 635 a, g dbSNP:139972151
638 638 c, t dbSNP:140501902
639 639 a, g, t dbSNP:769031756
642 642 c, t dbSNP:369622085
645 645 c, g dbSNP:748397935
646 646 a, t dbSNP:772372158
649 649 c, g dbSNP:773522773
663 663 c, t dbSNP:760961297
676 676 c, t dbSNP:549378958
678 678 a, g dbSNP:776842226
681 681 c, t dbSNP:63750048
682 682 a, g dbSNP:765023751
688 688 c, t dbSNP:1046240
689 689 c, g dbSNP:758086169
706 706 c, g dbSNP:200350640
715 715 c, t dbSNP:751261061
719 719 c, t dbSNP:756899463
720 720 a, g dbSNP:780738564
721 721 c, t dbSNP:146718524
723 723 c, t dbSNP:755514702
727 727 c, t dbSNP:200801915
728 728 a, g dbSNP:373392465
733 733 a, g dbSNP:748572509
742 742 c, t dbSNP:553495122
750 750 c, g dbSNP:778247625
755 755 c, t dbSNP:199808788
756 756 a, g, t dbSNP:747296921
763 763 c, t dbSNP:200610057
775 775 c, t dbSNP:201119121
791 791 a, c dbSNP:63749851
792 792 c, g, t dbSNP:28936380
793 793 a, g dbSNP:148996705
799 799 c, t dbSNP:753371172
802 802 c, t dbSNP:758985161
805 805 a, g dbSNP:547731225
809 809 a, g dbSNP:566361436
810 810 c, t dbSNP:752002301
816 816 c, t dbSNP:63750197
817 817 c, g dbSNP:781597971
826 826 c, g dbSNP:746117072
828 828 a, g, t dbSNP:756346917
837 837 a, g dbSNP:749301595
838 838 c, t dbSNP:200924879
841 841 c, t dbSNP:747738607
842 842 a, g, t dbSNP:202178897
845 845 c, t dbSNP:773059327
846 846 c, t dbSNP:760299337
848 848 a, t dbSNP:61761208
849 849 a, t dbSNP:63750215
850 850 c, t dbSNP:116003409
851 851 a, t dbSNP:201590095
856 856 c, t dbSNP:201196514
857 857 a, c dbSNP:764718172
866 866 a, g dbSNP:201892898
868 868 c, t dbSNP:114334281
869 869 a, g dbSNP:63750812
874 874 c, t dbSNP:767835970
882 882 c, t dbSNP:199654606
887 887 a, g dbSNP:139573101
894 894 g, t dbSNP:756296193
896 896 a, g, t dbSNP:780284265
909 909 a, g dbSNP:755101354
914 914 a, c dbSNP:200931244
915 915 a, g dbSNP:778936527
922 922 c, g dbSNP:748154107
932 932 a, c dbSNP:533813519
943 943 a, g dbSNP:745582651
947 947 a, g dbSNP:61757781
951 951 c, g dbSNP:775145486
955 955 a, g dbSNP:762485322
956 956 c, g dbSNP:772480664
964 964 a, g dbSNP:201896763
965 965 c, t dbSNP:773820169
967 967 a, g dbSNP:761057590
972 972 -, gg dbSNP:757877983
972 972 a, t dbSNP:766799482
978 978 c, t dbSNP:200210453
981 981 a, g dbSNP:567036599
983 983 -, t dbSNP:751120699
993 993 c, g dbSNP:371686514
997 997 a, c dbSNP:202176021
1009 1009 c, t dbSNP:765464734
1011 1011 a, g dbSNP:200410369
1014 1014 a, g dbSNP:753009383
1015 1015 c, t dbSNP:144629723
1016 1016 a, g dbSNP:770238439
1017 1017 a, t dbSNP:751577358
1019 1019 g, t dbSNP:757273954
1022 1022 a, c dbSNP:767523385
1032 1032 c, t dbSNP:750266631
1036 1036 c, t dbSNP:756024386
1045 1045 a, g dbSNP:779684855
1048 1048 a, t dbSNP:749034384
1051 1051 a, c dbSNP:754571073
1058 1058 g, t dbSNP:201671829
1060 1060 a, c, t dbSNP:199760083
1061 1061 a, g dbSNP:200173519
1066 1066 a, g dbSNP:555809980
1067 1067 a, g, t dbSNP:574125890
1069 1069 g, t dbSNP:190477948
1101 1101 c, t dbSNP:763295042
1102 1102 g, t dbSNP:764165210
1110 1110 a, t dbSNP:63750880
1117 1117 c, g dbSNP:145010538
1119 1119 -, c dbSNP:754569211
1119 1119 a, g dbSNP:200754713
1124 1124 a, g dbSNP:201908554
1126 1126 c, g dbSNP:750424014
1135 1135 c, t dbSNP:61730652
1137 1137 c, t dbSNP:200670135
1138 1138 a, g dbSNP:202003390
1139 1139 c, t dbSNP:367855127
1142 1142 a, g dbSNP:28936379
1144 1144 a, g dbSNP:63749884
1145 1145 g, t dbSNP:778393774
1152 1152 c, t dbSNP:200133314
1156 1156 c, g dbSNP:371562367
1159 1159 c, t dbSNP:757955974
1163 1163 c, t dbSNP:777235854
1166 1166 c, t dbSNP:140562931
1171 1171 a, g dbSNP:145400391
1180 1180 c, t dbSNP:200332829
1181 1181 a, g dbSNP:138836272
1182 1182 c, g, t dbSNP:201403206
1183 1183 a, c, g dbSNP:147702142
1187 1187 a, g dbSNP:773410250
1190 1190 a, t dbSNP:201292728
1192 1192 c, t dbSNP:760698293
1196 1196 a, g dbSNP:766159571
1197 1197 g, t dbSNP:369429245
1198 1198 c, g, t dbSNP:7539017
1199 1199 a, g, t dbSNP:148238688
1208 1208 c, g dbSNP:201055590
1208 1208 -, g dbSNP:781053654
1210 1210 a, g dbSNP:202210060
1217 1217 c, t dbSNP:200694973
1219 1219 c, g, t dbSNP:77875620
1220 1220 a, g dbSNP:199707432
1225 1225 c, t dbSNP:200644982
1227 1227 g, t dbSNP:77421307
1228 1228 a, g dbSNP:780721688
1231 1231 c, g dbSNP:201606093
1241 1241 a, g dbSNP:755495216
1244 1244 a, c dbSNP:779431743
1258 1258 a, g dbSNP:748453717
1268 1268 g, t dbSNP:772451160
1281 1281 a, g dbSNP:150780392
1288 1288 c, t dbSNP:75733498
1299 1299 c, t dbSNP:374055800
1301 1301 c, g dbSNP:776770770
1304 1304 a, t dbSNP:199689738
1307 1307 c, t dbSNP:769715316
1311 1311 c, t dbSNP:200668817
1315 1315 c, t dbSNP:772626008
1328 1328 a, t dbSNP:760178182
1329 1329 c, t dbSNP:144277432
1330 1330 a, g, t dbSNP:6426553
1341 1341 a, c, t dbSNP:200501733
1342 1342 a, g dbSNP:75357954
1354 1354 c, t dbSNP:200326485
1355 1355 c, t dbSNP:781436525
1357 1357 c, g dbSNP:745958627
1364 1364 a, g dbSNP:756225509
1369 1369 c, g, t dbSNP:780103765
1374 1374 a, g dbSNP:201778576
1381 1381 c, t dbSNP:199587016
1383 1383 a, g dbSNP:547494670
1384 1384 c, t dbSNP:747932826
1385 1385 a, c, g dbSNP:565698726
1388 1388 c, g dbSNP:753390653
1392 1392 a, g dbSNP:760376643
1407 1407 -, t dbSNP:765039787
1416 1416 c, t dbSNP:373934941
1417 1417 c, g, t dbSNP:200044441
1421 1421 c, g dbSNP:758259518
1424 1424 a, c, g dbSNP:777639021
1425 1425 c, g dbSNP:63750207
1429 1429 a, g, t dbSNP:781365270
1435 1435 c, t dbSNP:769386876
1436 1436 a, g dbSNP:559617407
1438 1438 a, g dbSNP:530065304
1439 1439 a, g dbSNP:201917728
1447 1447 a, g dbSNP:199881176
1448 1448 c, t dbSNP:773597667
1453 1453 c, t dbSNP:760977533
1465 1465 a, c dbSNP:766705508
1466 1466 c, g dbSNP:776874000
1469 1469 a, g dbSNP:759669954
1473 1473 a, g dbSNP:78420366
1476 1476 a, g dbSNP:765420103
1492 1492 a, g dbSNP:200977587
1493 1493 -, a dbSNP:773094480
1498 1498 a, g dbSNP:575912514
1500 1500 c, g dbSNP:779522932
1501 1501 c, g, t dbSNP:753503617
1502 1502 a, g dbSNP:563053551
1516 1516 c, t dbSNP:201093218
1519 1519 a, g dbSNP:771373304
1533 1533 a, c dbSNP:781543554
1545 1545 c, t dbSNP:746182253
1546 1546 a, g dbSNP:770080595
1552 1552 a, g dbSNP:539696910
1554 1554 c, t dbSNP:199714082
1555 1555 a, g dbSNP:377489312
1556 1556 c, g dbSNP:774513973
1558 1558 a, t dbSNP:761844882
1563 1563 a, c dbSNP:143912759
1564 1564 a, g dbSNP:377494557
1570 1570 -, g dbSNP:766393518
1570 1570 c, t dbSNP:760432548
1572 1572 a, g dbSNP:145671982
1573 1573 c, g dbSNP:201772526
1576 1576 c, g dbSNP:199550349
1577 1577 a, t dbSNP:753499090
1580 1580 a, c dbSNP:149172004
1587 1587 c, t dbSNP:143549266
1588 1588 a, c, g dbSNP:369274454
1591 1591 a, g dbSNP:781506963
1600 1600 c, t dbSNP:115652716
1601 1601 a, g dbSNP:142690225
1610 1610 c, t dbSNP:780464244
1612 1612 a, c dbSNP:749533069
1613 1613 a, c dbSNP:768931743
1624 1624 c, t dbSNP:138494303
1629 1629 c, t dbSNP:746930366
1632 1632 a, t dbSNP:770838733
1644 1644 a, c dbSNP:371315050
1653 1653 a, g dbSNP:759282140
1656 1656 a, g dbSNP:764998593
1659 1659 c, t dbSNP:775164469
1660 1660 a, g dbSNP:201982084
1664 1664 c, t dbSNP:200427880
1666 1666 c, t dbSNP:751025333
1667 1667 a, g dbSNP:201494033
1672 1672 c, t dbSNP:555914170
1676 1676 a, g dbSNP:199796978
1686 1686 c, t dbSNP:756609078
1687 1687 a, g, t dbSNP:766859560
1690 1690 c, g, t dbSNP:200169735
1693 1693 a, g dbSNP:748435174
1697 1697 a, g dbSNP:758586194
1699 1699 c, t dbSNP:777716175
1703 1703 c, t dbSNP:747074838
1708 1708 c, t dbSNP:144318314
1713 1713 c, t dbSNP:63750666
1717 1717 a, c dbSNP:776603544
1718 1718 a, c dbSNP:199676786
1723 1723 a, g dbSNP:769644784
1725 1725 g, t dbSNP:775252540
1727 1727 c, t dbSNP:142772982
1728 1728 a, g dbSNP:201922151
1729 1729 g, t dbSNP:773754382
1731 1731 a, c, t dbSNP:749755334
1732 1732 a, g dbSNP:199547508
1736 1736 a, g dbSNP:200804459
1737 1737 c, t dbSNP:750161150
1740 1740 a, c dbSNP:63750110
1741 1741 c, t dbSNP:201424233
1754 1754 c, t dbSNP:151048692
1762 1762 c, g dbSNP:758582618
1766 1766 a, g dbSNP:778005647
1774 1774 a, g, t dbSNP:200164062
1777 1777 a, g dbSNP:371693894
1789 1789 a, g dbSNP:200745703
1791 1791 a, g dbSNP:201399057
1797 1797 a, g dbSNP:769663194
1804 1804 a, g dbSNP:779830498
1815 1815 c, t dbSNP:200016565
1819 1819 a, g dbSNP:768312153
1823 1823 a, c dbSNP:774092766
1842 1842 a, c dbSNP:537889666
1844 1844 a, c dbSNP:550113178
1852 1852 a, g, t dbSNP:200943229
1865 1865 c, t dbSNP:202239448
1874 1874 c, t dbSNP:571670427
1891 1891 a, g dbSNP:143059995
1903 1903 c, t dbSNP:186288674
1913 1913 a, g dbSNP:201163703
1959 1959 c, t dbSNP:202067223
1961 1961 a, c dbSNP:200407641
1964 1964 a, c, g dbSNP:201559102
1976 1976 a, g dbSNP:199571588
1980 1980 c, t dbSNP:571949639
1981 1981 a, g dbSNP:200296479
1982 1982 c, g dbSNP:542892604
1987 1987 c, t dbSNP:201488196
1988 1988 a, g dbSNP:199791100
1988 1988 -, g dbSNP:144289421
1989 1989 g, t dbSNP:774892527
2009 2009 c, t dbSNP:200615414
2041 2041 c, t dbSNP:8383
2043 2043 a, g dbSNP:771604803
2055 2055 a, t dbSNP:199645229
2058 2058 a, g dbSNP:200641411
2061 2061 a, t dbSNP:201605500
2077 2077 a, g dbSNP:145129440
2079 2079 -, aa dbSNP:772387766
2083 2083 a, c dbSNP:200559114
2084 2084 a, g dbSNP:201773209
2091 2091 c, t dbSNP:200161165
2113 2113 g, t dbSNP:200923178
2122 2122 a, g dbSNP:202178096
2133 2133 a, g dbSNP:199949722
2147 2147 a, g dbSNP:201114015
2148 2148 c, t dbSNP:202160009
2149 2149 c, g dbSNP:200173939
2163 2163 a, g dbSNP:201510179
2176 2176 g, t dbSNP:116807339
2185 2185 a, g dbSNP:200536369
2212 2212 g, t dbSNP:201603449
2225 2225 a, t dbSNP:199579988
2226 2226 c, t dbSNP:200568747
2237 2237 c, t dbSNP:191115973
2240 2240 c, t dbSNP:541168117
2245 2245 a, g dbSNP:559491058
2250 2250 g, t dbSNP:201177570
2258 2258 c, g dbSNP:7962
2275 2275 a, g dbSNP:549584732
2277 2277 a, g dbSNP:561437447
2295 2295 a, g dbSNP:200610385

Target ORF information:

RefSeq Version NM_012486
Organism Homo sapiens (human)
Definition Homo sapiens presenilin 2 (PSEN2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012486

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTA 
ATGTCGGCTG AGAGCCCCAC GCCGCGCTCC TGCCAGGAGG GCAGGCAGGG CCCAGAGGAT
GGAGAGAACA CTGCCCAGTG GAGAAGCCAG GAGAACGAGG AGGACGGTGA GGAGGACCCT
GACCGCTATG TCTGTAGTGG GGTTCCCGGG CGGCCGCCAG GCCTGGAGGA AGAGCTGACC
CTCAAATACG GAGCGAAGCA CGTGATCATG CTGTTTGTGC CTGTCACTCT GTGCATGATC
GTGGTGGTAG CCACCATCAA GTCTGTGCGC TTCTACACAG AGAAGAATGG ACAGCTCATC
TACACGCCAT TCACTGAGGA CACACCCTCG GTGGGCCAGC GCCTCCTCAA CTCCGTGCTG
AACACCCTCA TCATGATCAG CGTCATCGTG GTTATGACCA TCTTCTTGGT GGTGCTCTAC
AAGTACCGCT GCTACAAGTT CATCCATGGC TGGTTGATCA TGTCTTCACT GATGCTGCTG
TTCCTCTTCA CCTATATCTA CCTTGGGGAA GTGCTCAAGA CCTACAATGT GGCCATGGAC
TACCCCACCC TCTTGCTGAC TGTCTGGAAC TTCGGGGCAG TGGGCATGGT GTGCATCCAC
TGGAAGGGCC CTCTGGTGCT GCAGCAGGCC TACCTCATCA TGATCAGTGC GCTCATGGCC
CTAGTGTTCA TCAAGTACCT CCCAGAGTGG TCCGCGTGGG TCATCCTGGG CGCCATCTCT
GTGTATGATC TCGTGGCTGT GCTGTGTCCC AAAGGGCCTC TGAGAATGCT GGTAGAAACT
GCCCAGGAGA GAAATGAGCC CATATTCCCT GCCCTGATAT ACTCATCTGC CATGGTGTGG
ACGGTTGGCA TGGCGAAGCT GGACCCCTCC TCTCAGGGTG CCCTCCAGCT CCCCTACGAC
CCGGAGATGG AAGACTCCTA TGACAGTTTT GGGGAGCCTT CATACCCCGA AGTCTTTGAG
CCTCCCTTGA CTGGCTACCC AGGGGAGGAG CTGGAGGAAG AGGAGGAAAG GGGCGTGAAG
CTTGGCCTCG GGGACTTCAT CTTCTACAGT GTGCTGGTGG GCAAGGCGGC TGCCACGGGC
AGCGGGGACT GGAATACCAC GCTGGCCTGC TTCGTGGCCA TCCTCATTGG CTTGTGTCTG
ACCCTCCTGC TGCTTGCTGT GTTCAAGAAG GCGCTGCCCG CCCTCCCCAT CTCCATCACG
TTCGGGCTCA TCTTTTACTT CTCCACGGAC AACCTGGTGC GGCCGTTCAT GGACACCCTG
GCCTCCCATC AGCTCTACAT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.