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PTH cDNA ORF clone, Homo sapiens (human)

Gene Symbol PTH
Entrez Gene ID 5741
Full Name parathyroid hormone
Synonyms PTH1
General protein information
Preferred Names
parathyroid hormone
Names
parathyroid hormone
parathyrin
prepro-PTH
parathormone
parathyroid hormone 1
preproparathyroid hormone
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.3-p15.1

Summary The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

168450

Disorder Html: Hypoparathyroidism, autosomal dominant, 146200 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_000315 NP_000306 parathyroid hormone preproprotein



Homo sapiens (human) PTH NP_000306.1
Pan troglodytes (chimpanzee) PTH XP_003951890.1
Macaca mulatta (Rhesus monkey) PTH XP_001094024.1
Canis lupus familiaris (dog) PTH NP_001003302.1
Bos taurus (cattle) PTH NP_776379.2
Mus musculus (house mouse) Pth NP_065648.1
Rattus norvegicus (Norway rat) Pth NP_058740.1
Gallus gallus (chicken) PTH NP_990783.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PTH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27358
NM_000315 Homo sapiens parathyroid hormone (PTH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27358
Clone ID Related Accession (Same CDS sequence) NM_000315
Accession Version NM_000315.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 348bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product parathyroid hormone preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX106232.1, AA843660.1 and BX103059.1. This sequence is a reference standard in the RefSeqGene project. On Dec 17, 2003 this sequence version replaced gi:4506266. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX103059.1, V00597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337, SAMEA962343 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGATACCTG CAAAAGACAT GGCTAAAGTT ATGATTGTCA TGTTGGCAAT TTGTTTTCTT 
ACAAAATCGG ATGGGAAATC TGTTAAGAAG AGATCTGTGA GTGAAATACA GCTTATGCAT
AACCTGGGAA AACATCTGAA CTCGATGGAG AGAGTAGAAT GGCTGCGTAA GAAGCTGCAG
GATGTGCACA ATTTTGTTGC CCTTGGAGCT CCTCTAGCTC CCAGAGATGC TGGTTCCCAG
AGGCCCCGAA AAAAGGAAGA CAATGTCTTG GTTGAGAGCC ATGAAAAAAG TCTTGGAGAG
GCAGACAAAG CTGATGTGAA TGTATTAACT AAAGCTAAAT CCCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000306.1
CDS116..463
Misc Feature(1)14..16(+)
Misc Feature(2)191..460(+)
Misc Feature(3)200..454(+)
Exon (1)1..110
Gene:PTH
Gene Synonym:
Exon (2)111..201
Gene:PTH
Gene Synonym:
Exon (3)202..814
Gene:PTH
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000315
Organism Homo sapiens (human)
Definition Homo sapiens parathyroid hormone (PTH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000315

ORF Insert Sequence:

1
61
121
181
241
301
ATGATACCTG CAAAAGACAT GGCTAAAGTT ATGATTGTCA TGTTGGCAAT TTGTTTTCTT 
ACAAAATCGG ATGGGAAATC TGTTAAGAAG AGATCTGTGA GTGAAATACA GCTTATGCAT
AACCTGGGAA AACATCTGAA CTCGATGGAG AGAGTAGAAT GGCTGCGTAA GAAGCTGCAG
GATGTGCACA ATTTTGTTGC CCTTGGAGCT CCTCTAGCTC CCAGAGATGC TGGTTCCCAG
AGGCCCCGAA AAAAGGAAGA CAATGTCTTG GTTGAGAGCC ATGAAAAAAG TCTTGGAGAG
GCAGACAAAG CTGATGTGAA TGTATTAACT AAAGCTAAAT CCCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Nonoxidized, biologically active parathyroid hormone determines mortality in hemodialysis patients
J. Clin. Endocrinol. Metab. 98 (12), 4744-4751 (2013)
Tepel M, Armbruster FP, Gron HJ, Scholze A, Reichetzeder C, Roth HJ and Hocher B.


book

25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis
Arterioscler. Thromb. Vasc. Biol. 33 (11), 2639-2645 (2013)
Blondon M, Sachs M, Hoofnagle AN, Ix JH, Michos ED, Korcarz C, Gepner AD, Siscovick DS, Kaufman JD, Stein JH, Kestenbaum B and de Boer IH.


book

Genetic and clinical characteristics of korean patients with isolated hypoparathyroidism: from the Korean hypopara registry study
J. Korean Med. Sci. 28 (10), 1489-1495 (2013)
Park SY, Eom YS, Choi B, Yi HS, Yu SH, Lee K, Jin HS, Chung YS, Jung TS and Lee S.


book

Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH
J. Bone Miner. Res. 28 (10), 2094-2108 (2013)
Li C, Xing Q, Yu B, Xie H, Wang W, Shi C, Crane JL, Cao X and Wan M.


book

Determinants of fibroblast growth factor-23 and parathyroid hormone variability in dialysis patients
Am. J. Nephrol. 37 (5), 462-471 (2013)
Jia T, Qureshi AR, Brandenburg V, Ketteler M, Barany P, Heimburger O, Uhlin F, Magnusson P, Fernstrom A, Lindholm B, Stenvinkel P and Larsson TE.


book

Ectopic transcription of the parathyroid hormone gene in lymphocytes, lymphoblastoid cells and tumour tissue
J. Endocrinol. 135 (2), 249-256 (1992)
Handt O, Reis A and Schmidtke J.


book

A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism
Nat. Genet. 1 (2), 149-152 (1992)
Parkinson DB and Thakker RV.


book

The immune response of Lewis rats to peptide 68-88 of guinea pig myelin basic protein. I. T cell determinants
J. Immunol. 123 (4), 1540-1543 (1979)
Chou,C.H., Fritz,R.B., Chou,F.C. and Kibler,R.F.


book

Complete amino acid sequence of human parathyroid hormone
Biochemistry 17 (26), 5723-5729 (1978)
Keutmann,H.T., Sauer,M.M., Hendy,G.N., O'Riordan,L.H. and Potts,J.T. Jr.


book

A reinvestigation of the amino-terminal sequence of human parathyroid hormone
Biochemistry 14 (9), 1842-1847 (1975)
Keutmann,H.T., Niall,H.D., O'Riordan,J.L. and Potts,J.T. Jr.


 
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