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PTH parathyroid hormone [Homo sapiens (human)]

Gene Symbol PTH
Entrez Gene ID 5741
Full Name parathyroid hormone
Synonyms PTH1
General protein information
Preferred Names
parathyroid hormone
Names
parathyroid hormone
parathyrin
prepro-PTH
parathormone
parathyroid hormone 1
preproparathyroid hormone
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.3-p15.1

Summary The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

168450

Disorder Html: Hypoparathyroidism, autosomal dominant, 146200 (3);





The following PTH gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTH gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27358 NM_000315 Homo sapiens parathyroid hormone (PTH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27358
Accession Version NM_000315.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 348bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu27358D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product parathyroid hormone preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX106232.1, AA843660.1 and BX103059.1. This sequence is a reference standard in the RefSeqGene project. On Dec 17, 2003 this sequence version replaced gi:4506266. Summary: The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX103059.1, V00597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337, SAMEA962343 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGATACCTG CAAAAGACAT GGCTAAAGTT ATGATTGTCA TGTTGGCAAT TTGTTTTCTT 
ACAAAATCGG ATGGGAAATC TGTTAAGAAG AGATCTGTGA GTGAAATACA GCTTATGCAT
AACCTGGGAA AACATCTGAA CTCGATGGAG AGAGTAGAAT GGCTGCGTAA GAAGCTGCAG
GATGTGCACA ATTTTGTTGC CCTTGGAGCT CCTCTAGCTC CCAGAGATGC TGGTTCCCAG
AGGCCCCGAA AAAAGGAAGA CAATGTCTTG GTTGAGAGCC ATGAAAAAAG TCTTGGAGAG
GCAGACAAAG CTGATGTGAA TGTATTAACT AAAGCTAAAT CCCAGTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000306.1
CDS116..463
Misc Feature(1)14..16(+)
Misc Feature(2)191..460(+)
Misc Feature(3)200..454(+)
Exon (1)1..110
Gene:PTH
Gene Synonym:
Exon (2)111..201
Gene:PTH
Gene Synonym:
Exon (3)202..814
Gene:PTH
Gene Synonym:
Translation
Position Chain Variation Link
19 19 a, g dbSNP:192881849
53 53 c, t dbSNP:533235300
57 57 c, t dbSNP:148099533
83 83 c, t dbSNP:745726399
117 117 c, t dbSNP:539730185
118 118 -, gat dbSNP:774129461
150 150 c, t dbSNP:779984006
160 160 a, g dbSNP:758268920
167 167 c, t dbSNP:104894271
182 182 c, t dbSNP:104894272
183 183 a, c dbSNP:750295789
184 184 a, g dbSNP:377308600
185 185 g, t dbSNP:756406117
190 190 a, g dbSNP:752828673
195 195 a, c dbSNP:767807443
198 198 c, t dbSNP:759709735
201 201 a, g dbSNP:774514236
212 212 c, g dbSNP:370564990
215 215 a, g dbSNP:767865413
231 231 c, t dbSNP:769151895
237 237 a, g dbSNP:387907454
238 238 c, t dbSNP:755183877
239 239 c, t dbSNP:751747610
241 241 a, g dbSNP:766545391
242 242 c, g dbSNP:142613980
244 244 a, g dbSNP:773625324
250 250 c, t dbSNP:149916515
258 258 c, t dbSNP:762100011
259 259 a, g dbSNP:376145884
260 260 a, g dbSNP:147730858
267 267 c, g dbSNP:768367860
270 270 a, t dbSNP:746647774
272 272 c, g dbSNP:775025715
275 275 c, t dbSNP:771537090
281 281 c, t dbSNP:199955107
282 282 a, g dbSNP:778737005
292 292 a, g dbSNP:374608791
298 298 c, t dbSNP:370961197
311 311 a, g dbSNP:200119869
316 316 c, t dbSNP:540157071
317 317 -, c dbSNP:749037995
317 317 c, t dbSNP:369252497
318 318 c, g, t dbSNP:150454177
320 320 a, g dbSNP:780385257
345 345 a, c dbSNP:201237944
347 347 a, g dbSNP:750463292
350 350 -, c dbSNP:35645521
360 360 c, t dbSNP:765671122
362 362 a, c, t dbSNP:6256
363 363 a, g dbSNP:777264966
370 370 a, g dbSNP:572350646
380 380 a, g dbSNP:760357380
388 388 g, t dbSNP:775152405
391 391 a, g dbSNP:76760723
395 395 c, t dbSNP:758980623
403 403 a, c dbSNP:542013340
404 404 -, a dbSNP:780166894
404 404 a, c dbSNP:373174306
410 410 c, g dbSNP:773844506
411 411 g, t dbSNP:770840441
415 415 a, g, t dbSNP:387907455
419 419 c, g dbSNP:777751836
425 425 a, g dbSNP:769744734
433 433 a, g dbSNP:747905244
460 460 a, g dbSNP:780438837
462 462 a, g dbSNP:758582203
486 486 a, g dbSNP:750538919
501 501 a, t dbSNP:779041849
504 504 a, g dbSNP:757748780
505 505 c, t dbSNP:754308544
513 513 a, c dbSNP:764541819
514 514 a, g dbSNP:369469373
518 518 c, t dbSNP:780806029
531 531 c, t dbSNP:764658271
532 532 a, g dbSNP:759108225
560 560 a, g dbSNP:574555824
570 570 c, t dbSNP:556177505
584 584 a, g dbSNP:574917764
635 635 c, t dbSNP:753717380
647 647 a, c dbSNP:537534711
648 648 -, attt dbSNP:542200556
649 649 -, tt dbSNP:758400220
650 650 -, tt dbSNP:111527388
652 652 -, gagtt dbSNP:571561564
652 652 g, t dbSNP:576904790
679 679 g, t dbSNP:35424808
696 696 a, g dbSNP:558107542
704 704 a, g dbSNP:766383678
737 737 a, t dbSNP:10189
762 762 a, g dbSNP:190896106
782 782 a, g dbSNP:16912873

Target ORF information:

RefSeq Version NM_000315
Organism Homo sapiens (human)
Definition Homo sapiens parathyroid hormone (PTH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000315

ORF Insert Sequence:

1
61
121
181
241
301
ATGATACCTG CAAAAGACAT GGCTAAAGTT ATGATTGTCA TGTTGGCAAT TTGTTTTCTT 
ACAAAATCGG ATGGGAAATC TGTTAAGAAG AGATCTGTGA GTGAAATACA GCTTATGCAT
AACCTGGGAA AACATCTGAA CTCGATGGAG AGAGTAGAAT GGCTGCGTAA GAAGCTGCAG
GATGTGCACA ATTTTGTTGC CCTTGGAGCT CCTCTAGCTC CCAGAGATGC TGGTTCCCAG
AGGCCCCGAA AAAAGGAAGA CAATGTCTTG GTTGAGAGCC ATGAAAAAAG TCTTGGAGAG
GCAGACAAAG CTGATGTGAA TGTATTAACT AAAGCTAAAT CCCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.