The following PTGS2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTGS2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1815bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||prostaglandin G/H synthase 2 precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA277667.1, BC013734.1,
AL033533.5, KF455116.1 and BM978796.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 17, 2014 this sequence version replaced gi:223941909.
Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as
cyclooxygenase, is the key enzyme in prostaglandin biosynthesis,
and acts both as a dioxygenase and as a peroxidase. There are two
isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2,
which differ in their regulation of expression and tissue
distribution. This gene encodes the inducible isozyme. It is
regulated by specific stimulatory events, suggesting that it is
responsible for the prostanoid biosynthesis involved in
inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC013734.1, M90100.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: full length.