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PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Homo sapiens (human)]

Gene Symbol PTGS2
Entrez Gene ID 5743
Full Name prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Synonyms COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
General protein information
Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
PHS II
PGH synthase 2
cyclooxygenase 2b
prostaglandin H2 synthase 2
NP_000954.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.2-q25.3

Summary Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]. lac of sum
Disorder MIM:

600262

Disorder Html:





The following PTGS2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTGS2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27989 NM_000963 Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27989
Accession Version NM_000963.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1815bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu27989D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product prostaglandin G/H synthase 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA277667.1, BC013734.1, AL033533.5, KF455116.1 and BM978796.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced gi:223941909. Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013734.1, M90100.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCTCGCCC GCGCCCTGCT GCTGTGCGCG GTCCTGGCGC TCAGCCATAC AGCAAATCCT 
TGCTGTTCCC ACCCATGTCA AAACCGAGGT GTATGTATGA GTGTGGGATT TGACCAGTAT
AAGTGCGATT GTACCCGGAC AGGATTCTAT GGAGAAAACT GCTCAACACC GGAATTTTTG
ACAAGAATAA AATTATTTCT GAAACCCACT CCAAACACAG TGCACTACAT ACTTACCCAC
TTCAAGGGAT TTTGGAACGT TGTGAATAAC ATTCCCTTCC TTCGAAATGC AATTATGAGT
TATGTGTTGA CATCCAGATC ACATTTGATT GACAGTCCAC CAACTTACAA TGCTGACTAT
GGCTACAAAA GCTGGGAAGC CTTCTCTAAC CTCTCCTATT ATACTAGAGC CCTTCCTCCT
GTGCCTGATG ATTGCCCGAC TCCCTTGGGT GTCAAAGGTA AAAAGCAGCT TCCTGATTCA
AATGAGATTG TGGAAAAATT GCTTCTAAGA AGAAAGTTCA TCCCTGATCC CCAGGGCTCA
AACATGATGT TTGCATTCTT TGCCCAGCAC TTCACGCATC AGTTTTTCAA GACAGATCAT
AAGCGAGGGC CAGCTTTCAC CAACGGGCTG GGCCATGGGG TGGACTTAAA TCATATTTAC
GGTGAAACTC TGGCTAGACA GCGTAAACTG CGCCTTTTCA AGGATGGAAA AATGAAATAT
CAGATAATTG ATGGAGAGAT GTATCCTCCC ACAGTCAAAG ATACTCAGGC AGAGATGATC
TACCCTCCTC AAGTCCCTGA GCATCTACGG TTTGCTGTGG GGCAGGAGGT CTTTGGTCTG
GTGCCTGGTC TGATGATGTA TGCCACAATC TGGCTGCGGG AACACAACAG AGTATGCGAT
GTGCTTAAAC AGGAGCATCC TGAATGGGGT GATGAGCAGT TGTTCCAGAC AAGCAGGCTA
ATACTGATAG GAGAGACTAT TAAGATTGTG ATTGAAGATT ATGTGCAACA CTTGAGTGGC
TATCACTTCA AACTGAAATT TGACCCAGAA CTACTTTTCA ACAAACAATT CCAGTACCAA
AATCGTATTG CTGCTGAATT TAACACCCTC TATCACTGGC ATCCCCTTCT GCCTGACACC
TTTCAAATTC ATGACCAGAA ATACAACTAT CAACAGTTTA TCTACAACAA CTCTATATTG
CTGGAACATG GAATTACCCA GTTTGTTGAA TCATTCACCA GGCAAATTGC TGGCAGGGTT
GCTGGTGGTA GGAATGTTCC ACCCGCAGTA CAGAAAGTAT CACAGGCTTC CATTGACCAG
AGCAGGCAGA TGAAATACCA GTCTTTTAAT GAGTACCGCA AACGCTTTAT GCTGAAGCCC
TATGAATCAT TTGAAGAACT TACAGGAGAA AAGGAAATGT CTGCAGAGTT GGAAGCACTC
TATGGTGACA TCGATGCTGT GGAGCTGTAT CCTGCCCTTC TGGTAGAAAA GCCTCGGCCA
GATGCCATCT TTGGTGAAAC CATGGTAGAA GTTGGAGCAC CATTCTCCTT GAAAGGACTT
ATGGGTAATG TTATATGTTC TCCTGCCTAC TGGAAGCCAA GCACTTTTGG TGGAGAAGTG
GGTTTTCAAA TCATCAACAC TGCCTCAATT CAGTCTCTCA TCTGCAATAA CGTGAAGGGC
TGTCCCTTTA CTTCATTCAG TGTTCCAGAT CCAGAGCTCA TTAAAACAGT CACCATCAAT
GCAAGTTCTT CCCGCTCCGG ACTAGATGAT ATCAATCCCA CAGTACTACT AAAAGAACGT
TCGACTGAAC TGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000954.1
CDS138..1952
Misc Feature(1)192..299(+)
Misc Feature(2)195..239(+)
Misc Feature(3)360..1823(+)
Misc Feature(4)444..1697(+)
Misc Feature(5)468..1751(+)
Misc Feature(6)501..1817(+)
Misc Feature(7)537..1445(+)
Misc Feature(8)1683..1685(+)
Exon (1)1..189
Gene:PTGS2
Gene Synonym:
Exon (2)190..306
Gene:PTGS2
Gene Synonym:
Exon (3)307..450
Gene:PTGS2
Gene Synonym:
Exon (4)451..594
Gene:PTGS2
Gene Synonym:
Exon (5)595..776
Gene:PTGS2
Gene Synonym:
Exon (6)777..860
Gene:PTGS2
Gene Synonym:
Exon (7)861..1107
Gene:PTGS2
Gene Synonym:
Exon (8)1108..1394
Gene:PTGS2
Gene Synonym:
Exon (9)1395..1542
Gene:PTGS2
Gene Synonym:
Exon (10)1543..4493
Gene:PTGS2
Gene Synonym:
Translation
Position Chain Variation Link
13 13 g, t dbSNP:5271
20 20 a, t dbSNP:4648257
41 41 a, g dbSNP:200536996
58 58 c, t dbSNP:199630699
64 64 c, g dbSNP:201480185
67 67 c, t dbSNP:200564627
72 72 c, g dbSNP:751948234
75 75 c, t dbSNP:11567819
86 86 c, g dbSNP:201481563
87 87 a, g dbSNP:200278253
89 89 c, t dbSNP:201843465
98 98 a, g dbSNP:201014475
108 108 a, c dbSNP:534327880
111 111 c, g, t dbSNP:200209794
112 112 -, c dbSNP:34888870
119 119 a, c dbSNP:183937640
135 135 c, g dbSNP:3134592
135 135 a, c, g, t dbSNP:3134591
140 140 a, g dbSNP:20426
143 143 c, g dbSNP:751430176
144 144 c, g dbSNP:533479217
147 147 c, g dbSNP:200140544
150 150 a, g dbSNP:779244806
167 167 g, t dbSNP:201912060
171 171 c, t dbSNP:755298351
174 174 g, t dbSNP:200906212
185 185 c, t dbSNP:752671561
186 186 a, g dbSNP:199946406
203 203 c, t dbSNP:769129515
205 205 a, c dbSNP:199737603
206 206 c, t dbSNP:776392084
223 223 a, g dbSNP:771031623
232 232 a, g dbSNP:201588411
238 238 c, g dbSNP:746777440
256 256 a, g dbSNP:777767886
263 263 c, t dbSNP:200215667
269 269 c, t dbSNP:373824545
273 273 c, t dbSNP:199661060
275 275 g, t dbSNP:749451828
281 281 a, t dbSNP:368723361
306 306 a, c, t dbSNP:373745396
307 307 c, t dbSNP:764607381
314 314 a, t dbSNP:758723919
324 324 a, c, g dbSNP:189809394
354 354 a, g dbSNP:764773998
358 358 g, t dbSNP:759289241
362 362 c, g dbSNP:753282331
369 369 c, t dbSNP:765917101
373 373 c, g dbSNP:760272529
395 395 c, g dbSNP:773231889
396 396 a, g dbSNP:772180278
408 408 a, c dbSNP:199619767
410 410 c, t dbSNP:774262348
411 411 a, c dbSNP:201046652
421 421 a, g dbSNP:200132172
424 424 a, g dbSNP:145215600
425 425 c, t dbSNP:201906674
429 429 a, g dbSNP:747123567
440 440 c, t dbSNP:147896616
443 443 a, c, g dbSNP:5277
455 455 a, g dbSNP:557821908
467 467 c, t dbSNP:755319162
471 471 a, g dbSNP:749696563
481 481 c, t dbSNP:377655174
503 503 a, c, t dbSNP:200314986
508 508 a, c, g, t dbSNP:756733211
509 509 a, c, t dbSNP:202013754
510 510 c, t dbSNP:763970406
511 511 g, t dbSNP:762779324
513 513 a, g dbSNP:775312199
514 514 a, g dbSNP:766574554
518 518 c, t dbSNP:539933723
527 527 c, t dbSNP:20429
533 533 c, t dbSNP:4648264
535 535 a, g dbSNP:566984593
539 539 c, t dbSNP:201938310
548 548 a, c dbSNP:200911813
557 557 c, t dbSNP:199972508
569 569 c, t dbSNP:4648265
574 574 c, t dbSNP:536033236
575 575 a, g dbSNP:201238353
580 580 c, t dbSNP:780636784
582 582 c, t dbSNP:756554922
597 597 a, g dbSNP:774340680
599 599 a, g dbSNP:142741435
613 613 a, g dbSNP:749747614
615 615 g, t dbSNP:200842448
619 619 a, g dbSNP:776157771
626 626 a, t dbSNP:770236383
635 635 a, g dbSNP:746268358
647 647 a, g dbSNP:780866771
651 651 a, g dbSNP:199513587
653 653 c, g dbSNP:770539837
656 656 c, t dbSNP:746514317
670 670 a, g dbSNP:535541309
674 674 c, t dbSNP:148479703
695 695 a, c dbSNP:201493026
713 713 a, g dbSNP:200316914
734 734 c, t dbSNP:199735403
737 737 a, c, t dbSNP:372267158
739 739 a, t dbSNP:753612005
742 742 a, g dbSNP:141500962
761 761 c, t dbSNP:200311544
762 762 a, g dbSNP:751815873
764 764 a, g dbSNP:201592586
773 773 c, t dbSNP:140664948
792 792 a, g dbSNP:538414051
797 797 c, t dbSNP:200000802
798 798 a, g dbSNP:765827639
807 807 c, g dbSNP:558977656
812 812 a, t dbSNP:777198225
819 819 a, c, t dbSNP:761122494
820 820 a, g dbSNP:3218622
847 847 a, g dbSNP:771747733
849 849 a, g dbSNP:747632855
869 869 c, t dbSNP:201616417
878 878 a, g dbSNP:186230736
879 879 c, t dbSNP:745639034
890 890 a, t dbSNP:781201501
895 895 a, g dbSNP:369291855
905 905 a, g dbSNP:768895902
917 917 c, t dbSNP:199504824
920 920 c, t dbSNP:201377871
929 929 a, c dbSNP:779300029
932 932 c, t dbSNP:113771132
944 944 a, g dbSNP:753987791
945 945 c, t dbSNP:201723686
946 946 a, c, g dbSNP:756699181
947 947 g, t dbSNP:200279549
953 953 c, t dbSNP:150242385
956 956 a, g dbSNP:372801628
961 961 a, g dbSNP:767815237
980 980 c, g dbSNP:762189430
987 987 c, t dbSNP:773957419
992 992 a, g dbSNP:763851146
994 994 c, t dbSNP:755163066
1005 1005 a, g dbSNP:762349072
1007 1007 c, g dbSNP:775124209
1008 1008 c, t dbSNP:769616622
1013 1013 a, g dbSNP:201837693
1014 1014 a, c dbSNP:776721278
1015 1015 a, g dbSNP:148160346
1034 1034 c, t dbSNP:201011990
1035 1035 a, g dbSNP:200204426
1037 1037 c, t dbSNP:5278
1038 1038 a, g dbSNP:749311409
1052 1052 c, g dbSNP:780245288
1061 1061 a, g dbSNP:756149409
1066 1066 a, g dbSNP:201228846
1077 1077 c, t dbSNP:200101876
1097 1097 a, g dbSNP:202086424
1104 1104 a, t dbSNP:781689400
1106 1106 a, t dbSNP:560493125
1112 1112 a, g dbSNP:201006741
1120 1120 a, g dbSNP:199520386
1142 1142 a, g dbSNP:3218623
1147 1147 a, g dbSNP:200843740
1149 1149 c, t dbSNP:199709318
1159 1159 a, g dbSNP:371762608
1163 1163 a, c dbSNP:201764120
1182 1182 a, c dbSNP:764827141
1200 1200 a, g dbSNP:759085374
1219 1219 a, g dbSNP:200479241
1235 1235 a, g dbSNP:147906320
1240 1240 a, g dbSNP:766401496
1241 1241 c, t dbSNP:760757126
1259 1259 c, t dbSNP:773024161
1283 1283 a, t dbSNP:767282746
1286 1286 c, t dbSNP:776531525
1292 1292 c, t dbSNP:775752439
1296 1296 a, g dbSNP:770054837
1301 1301 c, t dbSNP:745938962
1302 1302 a, c dbSNP:776759044
1304 1304 c, t dbSNP:771005303
1305 1305 c, t dbSNP:201708424
1313 1313 a, g dbSNP:747495204
1316 1316 a, t dbSNP:778162839
1331 1331 c, t dbSNP:758747837
1332 1332 a, g dbSNP:748500299
1333 1333 c, t dbSNP:367650109
1337 1337 a, g dbSNP:3218624
1346 1346 a, c, t dbSNP:5279
1353 1353 a, t dbSNP:765917214
1357 1357 a, g dbSNP:755696929
1361 1361 g, t dbSNP:202093833
1372 1372 c, t dbSNP:750338422
1385 1385 c, t dbSNP:767397966
1386 1386 a, g dbSNP:761649861
1387 1387 c, t dbSNP:201373237
1395 1395 a, g dbSNP:773830437
1398 1398 a, g dbSNP:770221043
1412 1412 c, t dbSNP:749953403
1419 1419 c, g, t dbSNP:4648279
1421 1421 c, t dbSNP:751502386
1422 1422 a, g, t dbSNP:202020013
1424 1424 a, g dbSNP:762760717
1425 1425 g, t dbSNP:754018195
1427 1427 a, g dbSNP:766627584
1431 1431 a, g dbSNP:760785915
1433 1433 a, g dbSNP:773222346
1443 1443 g, t dbSNP:139215497
1449 1449 a, g dbSNP:772624685
1450 1450 c, t dbSNP:762156881
1451 1451 c, t dbSNP:775008772
1454 1454 c, t dbSNP:200089522
1466 1466 c, g dbSNP:749712692
1481 1481 c, t dbSNP:146262134
1482 1482 c, t dbSNP:769393500
1484 1484 c, t dbSNP:200652624
1498 1498 a, g dbSNP:745382650
1500 1500 c, t dbSNP:780502264
1511 1511 a, g dbSNP:200025327
1517 1517 c, g dbSNP:756805754
1520 1520 c, t dbSNP:61757788
1526 1526 a, t dbSNP:751451093
1535 1535 a, g dbSNP:748480848
1548 1548 a, g dbSNP:139787656
1550 1550 a, g dbSNP:777664238
1558 1558 c, t dbSNP:758387677
1560 1560 a, g dbSNP:752484376
1569 1569 a, g dbSNP:141702884
1573 1573 c, t dbSNP:754811569
1577 1577 a, c dbSNP:554763999
1579 1579 a, g dbSNP:767810225
1581 1581 a, g dbSNP:267598241
1584 1584 a, g dbSNP:189679860
1587 1587 a, g dbSNP:751749337
1596 1596 a, g dbSNP:764695479
1600 1600 a, g dbSNP:5272
1613 1613 a, c dbSNP:763487671
1628 1628 c, g dbSNP:776081537
1632 1632 c, t dbSNP:201405348
1633 1633 a, g, t dbSNP:200408009
1634 1634 a, g dbSNP:4648288
1649 1649 c, t dbSNP:756084564
1650 1650 a, g dbSNP:200926368
1655 1655 a, c dbSNP:776118678
1660 1660 c, t dbSNP:770663212
1667 1667 a, t dbSNP:200030471
1669 1669 c, g, t dbSNP:5273
1687 1687 c, t dbSNP:771571521
1706 1706 a, t dbSNP:748021098
1707 1707 a, g dbSNP:201342852
1710 1710 a, t dbSNP:199820825
1721 1721 g, t dbSNP:754687795
1722 1722 a, g dbSNP:749145998
1723 1723 c, t dbSNP:201922079
1733 1733 a, g dbSNP:541453486
1739 1739 c, t dbSNP:571688672
1764 1764 c, g dbSNP:751835602
1769 1769 c, t dbSNP:139087930
1771 1771 c, t dbSNP:200583134
1790 1790 a, g dbSNP:753108623
1799 1799 c, g dbSNP:765815931
1804 1804 a, g dbSNP:759794443
1808 1808 c, t dbSNP:200081470
1818 1818 a, t dbSNP:201730487
1823 1823 c, t dbSNP:777108523
1824 1824 c, t dbSNP:766007619
1836 1836 a, g dbSNP:201606460
1841 1841 a, t dbSNP:760249208
1848 1848 c, g dbSNP:772864590
1853 1853 c, g dbSNP:771520748
1869 1869 a, c dbSNP:200492220
1870 1870 c, t dbSNP:774122358
1890 1890 c, t dbSNP:768699687
1891 1891 a, g dbSNP:749033694
1892 1892 a, c dbSNP:5274
1894 1894 a, c dbSNP:201772944
1895 1895 c, t dbSNP:747184192
1896 1896 a, g dbSNP:3218625
1904 1904 c, t dbSNP:148865858
1905 1905 a, g dbSNP:373482960
1906 1906 a, g, t dbSNP:755571974
1907 1907 c, t dbSNP:199504402
1909 1909 c, t dbSNP:754301528
1925 1925 a, g dbSNP:542686634
1931 1931 a, g dbSNP:766668555
1936 1936 a, g, t dbSNP:201299558
1940 1940 a, g, t dbSNP:200312294
1955 1955 a, c, g dbSNP:561157840
1956 1956 g, t dbSNP:773979740
1961 1961 c, t dbSNP:768056746
1967 1967 g, t dbSNP:762892168
1971 1971 a, t dbSNP:775591657
1979 1979 a, t dbSNP:769676428
1980 1980 a, g dbSNP:745701374
1981 1981 c, t dbSNP:778122608
1982 1982 a, g dbSNP:199738725
1985 1985 a, t dbSNP:772483298
1988 1988 c, t dbSNP:766788918
1993 1993 a, c dbSNP:748169012
2001 2001 c, t dbSNP:778980844
2009 2009 c, t dbSNP:201534244
2029 2029 c, g dbSNP:759062921
2037 2037 a, g dbSNP:200232733
2048 2048 a, t dbSNP:542780589
2059 2059 a, t dbSNP:202188713
2073 2073 c, t dbSNP:4648289
2079 2079 c, t dbSNP:200536698
2080 2080 a, g, t dbSNP:201923275
2136 2136 c, g dbSNP:200786963
2150 2150 g, t dbSNP:200002596
2162 2162 g, t dbSNP:139462473
2199 2199 a, c, g dbSNP:4648290
2201 2201 c, t dbSNP:540976562
2214 2214 a, g dbSNP:199817349
2224 2224 -, ttata dbSNP:61352290
2228 2228 -, attat dbSNP:4648291
2229 2229 -, ttata dbSNP:36233646
2244 2244 c, t dbSNP:576764583
2270 2270 a, g dbSNP:1051896
2294 2294 a, g dbSNP:762245176
2319 2319 a, g dbSNP:201916655
2321 2321 a, g dbSNP:142234315
2331 2331 g, t dbSNP:199740331
2351 2351 a, g dbSNP:201917851
2379 2379 c, t dbSNP:5275
2385 2385 g, t dbSNP:199629276
2402 2402 a, g dbSNP:13306031
2431 2431 c, t dbSNP:572939749
2441 2441 a, g dbSNP:201419014
2450 2450 a, g dbSNP:5276
2451 2451 c, t dbSNP:199506254
2459 2459 a, t dbSNP:201484578
2483 2483 a, g dbSNP:536428606
2487 2487 c, t dbSNP:200416386
2533 2533 a, c, t dbSNP:201842290
2534 2534 g, t dbSNP:762269568
2542 2542 g, t dbSNP:747223702
2546 2546 c, t dbSNP:138908498
2548 2548 c, t dbSNP:201014322
2554 2554 a, t dbSNP:200207384
2570 2570 c, t dbSNP:201745115
2579 2579 a, g dbSNP:201083629
2581 2581 c, g, t dbSNP:4648292
2599 2599 a, c dbSNP:538701450
2614 2614 a, t dbSNP:3134589
2630 2630 a, g dbSNP:4648293
2665 2665 g, t dbSNP:201104814
2693 2693 a, t dbSNP:115973952
2701 2701 c, t dbSNP:534809418
2713 2713 c, t dbSNP:201782015
2749 2749 a, g dbSNP:4648294
2761 2761 c, t dbSNP:200795899
2767 2767 c, t dbSNP:1051897
2811 2811 c, t dbSNP:199858950
2814 2814 a, c dbSNP:201688357
2821 2821 c, t dbSNP:200717726
2822 2822 a, g dbSNP:199740165
2831 2831 a, c dbSNP:201588251
2833 2833 a, g dbSNP:193144472
2844 2844 a, g dbSNP:199657133
2871 2871 c, g dbSNP:201157576
2878 2878 g, t dbSNP:200351050
2882 2882 a, t dbSNP:201923503
2890 2890 a, t dbSNP:201467945
2892 2892 a, g, t dbSNP:200400596
2918 2918 a, c dbSNP:778888429
2928 2928 c, t dbSNP:202215792
2934 2934 -, g dbSNP:780260168
2934 2934 a, t dbSNP:747178658
2976 2976 a, g dbSNP:530994465
3008 3008 c, t dbSNP:2206593
3010 3010 a, g dbSNP:552048991
3028 3028 c, t dbSNP:2853804
3036 3036 a, g dbSNP:199859157
3048 3048 a, t dbSNP:150239498
3052 3052 c, g dbSNP:202024704
3075 3075 a, g dbSNP:564911033
3079 3079 a, t dbSNP:540204815
3091 3091 a, g dbSNP:201042127
3106 3106 a, g dbSNP:4648295
3122 3122 c, t dbSNP:200089422
3130 3130 a, t dbSNP:560946853
3152 3152 a, g dbSNP:749068028
3155 3155 c, t dbSNP:201908600
3162 3162 a, t dbSNP:200729681
3190 3190 a, g dbSNP:199966067
3197 3197 g, t dbSNP:202003593
3198 3198 c, t dbSNP:200679193
3254 3254 c, t dbSNP:190150368
3255 3255 a, g dbSNP:184845240
3264 3264 a, t dbSNP:200577098
3287 3287 a, t dbSNP:11567829
3301 3301 c, g dbSNP:201576572
3303 3303 c, t dbSNP:200295049
3312 3312 a, g dbSNP:568478222
3316 3316 a, g dbSNP:577829403
3319 3319 a, t dbSNP:202004599
3326 3326 a, g dbSNP:201595920
3341 3341 a, c dbSNP:200409468
3369 3369 c, t dbSNP:4648296
3378 3378 a, g dbSNP:4648297
3396 3396 a, g dbSNP:199947679
3403 3403 a, g dbSNP:202217156
3434 3434 a, g dbSNP:201238205
3437 3437 a, t dbSNP:368833559
3457 3457 g, t dbSNP:13306032
3518 3518 a, c dbSNP:187958342
3531 3531 c, t dbSNP:541341893
3535 3535 c, t dbSNP:13306033
3536 3536 c, g dbSNP:759297172
3548 3548 c, t dbSNP:183653397
3550 3550 a, g dbSNP:182127940
3560 3560 c, t dbSNP:200069207
3573 3573 a, t dbSNP:201601925
3580 3580 c, t dbSNP:200482826
3582 3582 c, t dbSNP:199602058
3590 3590 c, t dbSNP:13306035
3597 3597 a, c dbSNP:192334329
3612 3612 a, c dbSNP:200828213
3623 3623 a, t dbSNP:199505687
3631 3631 a, g dbSNP:528082472
3634 3634 a, c dbSNP:201377863
3643 3643 a, c dbSNP:200312413
3644 3644 c, t dbSNP:561009903
3646 3646 a, g dbSNP:199736988
3693 3693 c, t dbSNP:201532679
3698 3698 a, g dbSNP:200177856
3702 3702 c, t dbSNP:756045952
3710 3710 a, t dbSNP:202009206
3714 3714 a, g dbSNP:201231127
3729 3729 c, g dbSNP:200492640
3747 3747 a, g dbSNP:202243625
3748 3748 c, g dbSNP:200779240
3755 3755 a, g dbSNP:4648298
3768 3768 c, t dbSNP:201526173
3773 3773 a, c dbSNP:575211762
3780 3780 -, t dbSNP:397804274
3789 3789 -, t dbSNP:11384450
3790 3790 g, t dbSNP:200986059
3808 3808 a, c, t dbSNP:199850911
3808 3808 -, t dbSNP:3835508
3811 3811 c, t dbSNP:2853805
3828 3828 g, t dbSNP:11567830
3839 3839 a, g dbSNP:200845455
3845 3845 a, c dbSNP:3179567
3860 3860 g, t dbSNP:4648299
3898 3898 c, g dbSNP:552834364
3901 3901 c, t dbSNP:201917612
3910 3910 g, t dbSNP:200531158
3976 3976 c, t dbSNP:541069205
3996 3996 a, g dbSNP:199626279
4005 4005 a, c dbSNP:201415472
4026 4026 a, g dbSNP:4648300
4029 4029 a, c dbSNP:199834448
4039 4039 c, t dbSNP:201360946
4041 4041 c, g, t dbSNP:188254107
4042 4042 a, g dbSNP:202089327
4061 4061 a, g dbSNP:201006478
4079 4079 c, t dbSNP:4648301
4081 4081 c, g dbSNP:201730694
4092 4092 c, t dbSNP:200883517
4096 4096 g, t dbSNP:200097577
4119 4119 c, t dbSNP:183201650
4120 4120 a, g dbSNP:200985751
4121 4121 c, t dbSNP:200027430
4164 4164 g, t dbSNP:689467
4172 4172 a, g dbSNP:689468
4185 4185 a, c dbSNP:199854202
4198 4198 a, t dbSNP:369883147
4206 4206 a, t dbSNP:201684522
4219 4219 g, t dbSNP:4648302
4239 4239 c, t dbSNP:4648303
4240 4240 a, g dbSNP:689469
4278 4278 c, t dbSNP:200642986
4280 4280 a, c dbSNP:191788711
4306 4306 a, t dbSNP:201156755
4310 4310 -, t dbSNP:559089418
4310 4310 a, t dbSNP:13306038
4311 4311 -, a dbSNP:57974311
4311 4311 a, t dbSNP:201931599
4317 4317 a, t dbSNP:201061872
4319 4319 -, a dbSNP:149091810
4320 4320 -, a dbSNP:757813906
4320 4320 -, a dbSNP:371722469
4320 4320 a, c dbSNP:200428982
4321 4321 a, c, t dbSNP:202092932
4331 4331 c, t dbSNP:201348126
4333 4333 c, t dbSNP:185983564
4351 4351 a, c dbSNP:545225542
4369 4369 a, g dbSNP:199824454
4379 4379 a, c, g, t dbSNP:689470
4398 4398 c, g dbSNP:201039864
4409 4409 a, g dbSNP:559271434
4418 4418 a, t dbSNP:200076979
4420 4420 a, g dbSNP:372262132
4485 4485 c, t dbSNP:201913348

Target ORF information:

RefSeq Version NM_000963
Organism Homo sapiens (human)
Definition Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000963

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCTCGCCC GCGCCCTGCT GCTGTGCGCG GTCCTGGCGC TCAGCCATAC AGCAAATCCT 
TGCTGTTCCC ACCCATGTCA AAACCGAGGT GTATGTATGA GTGTGGGATT TGACCAGTAT
AAGTGCGATT GTACCCGGAC AGGATTCTAT GGAGAAAACT GCTCAACACC GGAATTTTTG
ACAAGAATAA AATTATTTCT GAAACCCACT CCAAACACAG TGCACTACAT ACTTACCCAC
TTCAAGGGAT TTTGGAACGT TGTGAATAAC ATTCCCTTCC TTCGAAATGC AATTATGAGT
TATGTGTTGA CATCCAGATC ACATTTGATT GACAGTCCAC CAACTTACAA TGCTGACTAT
GGCTACAAAA GCTGGGAAGC CTTCTCTAAC CTCTCCTATT ATACTAGAGC CCTTCCTCCT
GTGCCTGATG ATTGCCCGAC TCCCTTGGGT GTCAAAGGTA AAAAGCAGCT TCCTGATTCA
AATGAGATTG TGGAAAAATT GCTTCTAAGA AGAAAGTTCA TCCCTGATCC CCAGGGCTCA
AACATGATGT TTGCATTCTT TGCCCAGCAC TTCACGCATC AGTTTTTCAA GACAGATCAT
AAGCGAGGGC CAGCTTTCAC CAACGGGCTG GGCCATGGGG TGGACTTAAA TCATATTTAC
GGTGAAACTC TGGCTAGACA GCGTAAACTG CGCCTTTTCA AGGATGGAAA AATGAAATAT
CAGATAATTG ATGGAGAGAT GTATCCTCCC ACAGTCAAAG ATACTCAGGC AGAGATGATC
TACCCTCCTC AAGTCCCTGA GCATCTACGG TTTGCTGTGG GGCAGGAGGT CTTTGGTCTG
GTGCCTGGTC TGATGATGTA TGCCACAATC TGGCTGCGGG AACACAACAG AGTATGCGAT
GTGCTTAAAC AGGAGCATCC TGAATGGGGT GATGAGCAGT TGTTCCAGAC AAGCAGGCTA
ATACTGATAG GAGAGACTAT TAAGATTGTG ATTGAAGATT ATGTGCAACA CTTGAGTGGC
TATCACTTCA AACTGAAATT TGACCCAGAA CTACTTTTCA ACAAACAATT CCAGTACCAA
AATCGTATTG CTGCTGAATT TAACACCCTC TATCACTGGC ATCCCCTTCT GCCTGACACC
TTTCAAATTC ATGACCAGAA ATACAACTAT CAACAGTTTA TCTACAACAA CTCTATATTG
CTGGAACATG GAATTACCCA GTTTGTTGAA TCATTCACCA GGCAAATTGC TGGCAGGGTT
GCTGGTGGTA GGAATGTTCC ACCCGCAGTA CAGAAAGTAT CACAGGCTTC CATTGACCAG
AGCAGGCAGA TGAAATACCA GTCTTTTAAT GAGTACCGCA AACGCTTTAT GCTGAAGCCC
TATGAATCAT TTGAAGAACT TACAGGAGAA AAGGAAATGT CTGCAGAGTT GGAAGCACTC
TATGGTGACA TCGATGCTGT GGAGCTGTAT CCTGCCCTTC TGGTAGAAAA GCCTCGGCCA
GATGCCATCT TTGGTGAAAC CATGGTAGAA GTTGGAGCAC CATTCTCCTT GAAAGGACTT
ATGGGTAATG TTATATGTTC TCCTGCCTAC TGGAAGCCAA GCACTTTTGG TGGAGAAGTG
GGTTTTCAAA TCATCAACAC TGCCTCAATT CAGTCTCTCA TCTGCAATAA CGTGAAGGGC
TGTCCCTTTA CTTCATTCAG TGTTCCAGAT CCAGAGCTCA TTAAAACAGT CACCATCAAT
GCAAGTTCTT CCCGCTCCGG ACTAGATGAT ATCAATCCCA CAGTACTACT AAAAGAACGT
TCGACTGAAC TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.