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PTPN11 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens (human)]

Gene Symbol PTPN11
Entrez Gene ID 5781
Full Name protein tyrosine phosphatase, non-receptor type 11
Synonyms BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
General protein information
Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
tyrosine-protein phosphatase non-receptor type 11
PTP-2C
protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase 2C
NP_002825.3
NP_542168.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24

Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. lac of sum
Disorder MIM:

176876

Disorder Html: Noonan syndrome 1, 163950 (3); LEOPARD syndrome 1, 151100 (3);





The following PTPN11 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTPN11 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu46740 XM_006719526 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $439
OHu60047 XM_011538613 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $439
OHu46741 XM_006719527 PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $439
OHu25096 NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $499
OHu24957 NM_080601 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu46740
Accession Version XM_006719526.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1794bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product tyrosine-protein phosphatase non-receptor type 11 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_029419.13) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAG AAATGGAGCT GTCACCCACA TCAAGATTCA GAACACTGGT
GATTACTATG ACCTGTATGG AGGGGAGAAA TTTGCCACTT TGGCTGAGTT GGTCCAGTAT
TACATGGAAC ATCACGGGCA ATTAAAAGAG AAGAATGGAG ATGTCATTGA GCTTAAATAT
CCTCTGAACT GTGCAGATCC TACCTCTGAA AGGTGGTTTC ATGGACATCT CTCTGGGAAA
GAAGCAGAGA AATTATTAAC TGAAAAAGGA AAACATGGTA GTTTTCTTGT ACGAGAGAGC
CAGAGCCACC CTGGAGATTT TGTTCTTTCT GTGCGCACTG GTGATGACAA AGGGGAGAGC
AATGACGGCA AGTCTAAAGT GACCCATGTT ATGATTCGCT GTCAGGAACT GAAATACGAC
GTTGGTGGAG GAGAACGGTT TGATTCTTTG ACAGATCTTG TGGAACATTA TAAGAAGAAT
CCTATGGTGG AAACATTGGG TACAGTACTA CAACTCAAGC AGCCCCTTAA CACGACTCGT
ATAAATGCTG CTGAAATAGA AAGCAGAGTT CGAGAACTAA GCAAATTAGC TGAGACCACA
GATAAAGTCA AACAAGGCTT TTGGGAAGAA TTTGAGACAC TACAACAACA GGAGTGCAAA
CTTCTCTACA GCCGAAAAGA GGGTCAAAGG CAAGAAAACA AAAACAAAAA TAGATATAAA
AACATCCTGC CCTTTGATCA TACCAGGGTT GTCCTACACG ATGGTGATCC CAATGAGCCT
GTTTCAGATT ACATCAATGC AAATATCATC ATGCCTGAAT TTGAAACCAA GTGCAACAAT
TCAAAGCCCA AAAAGAGTTA CATTGCCACA CAAGGCTGCC TGCAAAACAC GGTGAATGAC
TTTTGGCGGA TGGTGTTCCA AGAAAACTCC CGAGTGATTG TCATGACAAC GAAAGAAGTG
GAGAGAGGAA AGAGTAAATG TGTCAAATAC TGGCCTGATG AGTATGCTCT AAAAGAATAT
GGCGTCATGC GTGTTAGGAA CGTCAAAGAA AGCGCCGCTC ATGACTATAC GCTAAGAGAA
CTTAAACTTT CAAAGGTTGG ACAAGCTCTA CTCCAGGGGA ATACGGAGAG AACGGTCTGG
CAATACCACT TTCGGACCTG GCCGGACCAC GGCGTGCCCA GCGACCCTGG GGGCGTGCTG
GACTTCCTGG AGGAGGTGCA CCATAAGCAG GAGAGCATCA TGGATGCAGG GCCGGTCGTG
GTGCACTGCA GTGCTGGAAT TGGCCGGACA GGGACGTTCA TTGTGATTGA TATTCTTATT
GACATCATCA GAGAGAAAGG TGTTGACTGC GATATTGACG TTCCCAAAAC CATCCAGATG
GTGCGGTCTC AGAGGTCAGG GATGGTCCAG ACAGAAGCAC AGTACCGATT TATCTATATG
GCGGTCCAGC ATTATATTGA AACACTACAG CGCAGGATTG AAGAAGAGCA GAAAAGCAAG
AGGAAAGGGC ACGAATATAC AAATATTAAG TATTCTCTAG CGGACCAGAC GAGTGGAGAT
CAGAGCCCTC TCCCGCCTTG TACTCCAACG CCACCCTGTG CAGAAATGAG AGAAGACAGT
GCTAGAGTCT ATGAAAACGT GGGCCTGATG CAACAGCAGA AAAGTTTCAG ATGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_006719589.1
CDS166..1959
Misc Feature(1)178..474(+)
Misc Feature(2)202..330(+)
Misc Feature(3)319..444(+)
Misc Feature(4)496..819(+)
Misc Feature(5)580..606(+)
Misc Feature(6)673..756(+)
Misc Feature(7)901..1737(+)
Misc Feature(8)991..1734(+)
Misc Feature(9)1450..1575(+)
Translation
Position Chain Variation Link
31 31 a, g dbSNP:527982856
45 45 g, t dbSNP:554487214
64 64 c, t dbSNP:567977545
76 76 a, g dbSNP:531915358
89 89 a, g dbSNP:766412799
106 106 g, t dbSNP:550428179
121 121 g, t dbSNP:587781131
139 139 a, g dbSNP:375495669
153 153 a, g dbSNP:760374212
170 170 c, t dbSNP:267606990
171 171 a, g dbSNP:768238710
178 178 a, g dbSNP:587781133
183 183 g, t dbSNP:79203122
190 190 c, g dbSNP:566068139
191 191 a, c dbSNP:536503257
193 193 a, g dbSNP:368633510
194 194 a, g dbSNP:200613531
201 201 c, t dbSNP:760086740
213 213 a, g dbSNP:372736227
217 217 a, g dbSNP:776089364
218 218 a, g dbSNP:587778635
221 221 g, t dbSNP:397507500
222 222 a, g dbSNP:764238610
223 223 c, g dbSNP:753951666
229 229 a, g dbSNP:757537175
231 231 a, g dbSNP:397516808
241 241 a, g dbSNP:750261927
279 279 g, t dbSNP:758209360
282 282 a, c dbSNP:779813529
284 284 a, g dbSNP:397516795
289 289 a, g dbSNP:397507501
297 297 a, c, t dbSNP:397507502
308 308 a, g dbSNP:765495843
313 313 a, g dbSNP:587778636
320 320 c, t dbSNP:397507503
321 321 c, t dbSNP:147388185
324 324 c, t dbSNP:766205831
331 331 a, g dbSNP:397507504
337 337 a, c, g, t dbSNP:397507505
338 338 a, g dbSNP:751437780
339 339 a, c, g dbSNP:397507506
343 343 -, ggt dbSNP:121918471
343 343 a, g, t dbSNP:397507507
344 344 gtga, t dbSNP:397507508
344 344 -, gtg dbSNP:80338836
344 344 c, g, t dbSNP:397507509
346 346 a, c, g dbSNP:397507510
347 347 a, c, g, t dbSNP:121918461
349 349 a, g, t dbSNP:121918460
353 353 a, g dbSNP:121918459
370 370 c, g dbSNP:397507511
371 371 a, t dbSNP:727503380
374 374 a, g dbSNP:397516801
376 376 c, g, t dbSNP:397507512
377 377 g, t dbSNP:755709231
379 379 a, c, g, t dbSNP:121918453
380 380 c, g, t dbSNP:121918454
381 381 c, t dbSNP:777529056
382 382 ac, ct dbSNP:397516802
382 382 a, c dbSNP:397507513
383 383 c, t dbSNP:121918462
391 391 a, c, g dbSNP:121918464
392 392 a, c, g, t dbSNP:121918465
393 393 c, g, t dbSNP:397507514
400 400 a, c dbSNP:397516803
401 401 a, g dbSNP:121918466
402 402 c, g dbSNP:748952554
409 409 a, g dbSNP:397507515
411 411 a, g dbSNP:753788277
420 420 c, t dbSNP:61736914
454 454 c, g dbSNP:397507516
460 460 a, t dbSNP:387907158
466 466 c, g dbSNP:747470140
475 475 c, t dbSNP:747300372
480 480 a, t dbSNP:397516804
482 482 a, c dbSNP:397507517
493 493 a, g dbSNP:397507518
494 494 a, c dbSNP:397507519
518 518 -, ct dbSNP:398122859
534 534 a, g, t dbSNP:755619262
541 541 c, t dbSNP:146497890
546 546 c, t dbSNP:757004128
555 555 a, g dbSNP:542711611
557 557 a, g dbSNP:397516805
574 574 -, gtacg dbSNP:398122857
577 577 c, t dbSNP:267606989
582 582 c, g, t dbSNP:397507520
591 591 c, t dbSNP:199498784
597 597 c, t dbSNP:758194931
616 616 c, g dbSNP:768927453
617 617 c, t dbSNP:202026962
620 620 a, g dbSNP:397507521
623 623 aagaacacaggggagagca, ctggtg dbSNP:398122858
626 626 c, g dbSNP:376027245
632 632 a, g dbSNP:200712424
642 642 c, g dbSNP:769848611
651 651 c, t dbSNP:397507522
652 652 a, g dbSNP:730880992
660 660 a, t dbSNP:771233518
682 682 c, t dbSNP:545138829
683 683 a, g, t dbSNP:369155025
684 684 c, g dbSNP:767425313
693 693 a, g dbSNP:775493749
694 694 c, g dbSNP:760660964
702 702 c, t dbSNP:141015445
705 705 c, t dbSNP:753269427
721 721 c, t dbSNP:143433437
722 722 a, g dbSNP:764663951
723 723 g, t dbSNP:200920312
730 730 g, t dbSNP:79068130
737 737 a, c, g dbSNP:370763866
750 750 a, c dbSNP:753107691
756 756 g, t dbSNP:76982592
759 759 a, g dbSNP:778211349
763 763 a, t dbSNP:727503381
781 781 c, t dbSNP:78376169
786 786 c, t dbSNP:757304894
795 795 a, g dbSNP:778919108
797 797 a, t dbSNP:745331641
816 816 c, g dbSNP:747243342
817 817 a, g dbSNP:768555552
819 819 a, g dbSNP:568340391
824 824 a, g dbSNP:780911423
826 826 -, a dbSNP:397516807
826 826 a, g, t dbSNP:397516806
848 848 g, t dbSNP:748085966
866 866 a, g dbSNP:730881220
882 882 c, g dbSNP:138215269
922 922 a, g dbSNP:773918720
927 927 a, g dbSNP:745489506
928 928 c, t dbSNP:771672596
932 932 a, g dbSNP:397507523
933 933 a, g dbSNP:775232682
935 935 -, aca dbSNP:397507524
939 939 g, t dbSNP:397516809
944 944 a, g dbSNP:773417679
946 946 c, t dbSNP:397507525
947 947 a, t dbSNP:765642157
950 950 a, g, t dbSNP:397507526
953 953 a, g dbSNP:763617831
958 958 a, c dbSNP:766531368
959 959 a, g dbSNP:376607329
966 966 g, t dbSNP:755104848
967 967 a, g, t dbSNP:397507527
979 979 a, g dbSNP:752966396
989 989 a, c dbSNP:397507528
992 992 a, g dbSNP:777603059
997 997 a, c dbSNP:749220083
999 999 a, g dbSNP:757228212
1001 1001 a, c, g dbSNP:121918456
1009 1009 a, g dbSNP:397507529
1011 1011 c, g dbSNP:397507530
1012 1012 a, c dbSNP:778374689
1017 1017 c, t dbSNP:571488248
1018 1018 c, g, t dbSNP:397507531
1019 1019 a, c, g, t dbSNP:121918463
1020 1020 g, t dbSNP:397516810
1023 1023 a, t dbSNP:397516811
1044 1044 c, g, t dbSNP:117730996
1045 1045 a, g dbSNP:376007642
1046 1046 a, g dbSNP:746607246
1058 1058 a, g dbSNP:572274623
1062 1062 a, g dbSNP:781010979
1078 1078 a, g dbSNP:730880995
1086 1086 a, g dbSNP:202019810
1087 1087 a, g dbSNP:28933386
1088 1088 a, c, g dbSNP:121918455
1090 1090 a, g dbSNP:201787206
1096 1096 a, g dbSNP:774939392
1097 1097 c, t dbSNP:201226824
1104 1104 a, g dbSNP:751028422
1112 1112 c, t dbSNP:547041954
1116 1116 a, g dbSNP:576405446
1118 1118 a, g dbSNP:747815170
1122 1122 c, t dbSNP:771407775
1132 1132 c, t dbSNP:779400765
1134 1134 a, c dbSNP:746329572
1136 1136 a, g dbSNP:772684421
1148 1148 c, t dbSNP:369430257
1150 1150 a, g dbSNP:760769867
1155 1155 a, c dbSNP:369739920
1161 1161 c, t dbSNP:397507533
1162 1162 a, t dbSNP:730880993
1176 1176 a, c, g dbSNP:371951288
1188 1188 c, t dbSNP:762516252
1193 1193 a, g dbSNP:535800148
1206 1206 a, g dbSNP:766297596
1213 1213 g, t dbSNP:146571700
1217 1217 a, g dbSNP:397507534
1218 1218 a, g dbSNP:190776554
1219 1219 c, g dbSNP:767192602
1222 1222 a, c dbSNP:752392909
1234 1234 a, g dbSNP:755871216
1236 1236 a, g dbSNP:779125362
1267 1267 a, g dbSNP:758737605
1285 1285 c, g dbSNP:397507535
1286 1286 a, g dbSNP:780328721
1289 1289 a, g dbSNP:41299183
1296 1296 a, c dbSNP:370059077
1308 1308 c, t dbSNP:781677115
1315 1315 c, t dbSNP:748162361
1318 1318 a, g dbSNP:769798916
1326 1326 c, t dbSNP:727505180
1327 1327 a, g dbSNP:749523268
1338 1338 c, t dbSNP:770730416
1339 1339 a, g dbSNP:774356443
1341 1341 c, t dbSNP:759533871
1355 1355 c, t dbSNP:767503386
1356 1356 a, g dbSNP:775571445
1382 1382 c, t dbSNP:760221298
1386 1386 a, g dbSNP:532529560
1390 1390 c, g, t dbSNP:779291780
1392 1392 c, t dbSNP:772022775
1393 1393 c, g dbSNP:377257792
1395 1395 a, g dbSNP:727504397
1403 1403 c, g dbSNP:201247699
1409 1409 a, c, t dbSNP:121918467
1415 1415 a, g dbSNP:761510407
1419 1419 c, g, t dbSNP:552394167
1443 1443 c, g dbSNP:759848374
1449 1449 a, g dbSNP:767920323
1454 1454 a, c dbSNP:727505389
1458 1458 c, t dbSNP:753173299
1459 1459 a, g dbSNP:397507536
1462 1462 c, t dbSNP:756647576
1473 1473 g, t dbSNP:150524715
1479 1479 c, t dbSNP:777895575
1485 1485 a, g dbSNP:753803665
1488 1488 c, t dbSNP:757362412
1492 1492 -, c dbSNP:398122860
1504 1504 c, t dbSNP:779236638
1522 1522 a, g dbSNP:746112827
1539 1539 a, g dbSNP:771967829
1543 1543 a, g, t dbSNP:397516796
1551 1551 a, c dbSNP:727504393
1558 1558 a, g, t dbSNP:121918468
1559 1559 c, g dbSNP:397509344
1568 1568 c, g dbSNP:121918469
1579 1579 a, c dbSNP:397507537
1580 1580 c, t dbSNP:121918457
1581 1581 c, g dbSNP:587781130
1585 1585 a, g dbSNP:779978269
1602 1602 c, t dbSNP:746719818
1608 1608 c, t dbSNP:139196273
1616 1616 a, g dbSNP:754837922
1617 1617 a, g dbSNP:780946087
1626 1626 g, t dbSNP:143238917
1630 1630 g, t dbSNP:397507538
1635 1635 c, t dbSNP:751834261
1637 1637 a, g dbSNP:730880994
1644 1644 c, t dbSNP:539373294
1645 1645 a, g dbSNP:781083623
1648 1648 a, c, g, t dbSNP:397507539
1649 1649 a, c, t dbSNP:397507540
1660 1660 c, g dbSNP:756104635
1669 1669 c, t dbSNP:397507541
1670 1670 g, t dbSNP:397507542
1679 1679 a, g dbSNP:397507543
1681 1681 a, g, t dbSNP:121918458
1682 1682 c, t dbSNP:397507544
1684 1684 a, c, g dbSNP:397507545
1685 1685 a, c, g, t dbSNP:397507546
1687 1687 a, g dbSNP:397507547
1693 1693 c, t dbSNP:387907157
1694 1694 ag, cc dbSNP:397509345
1694 1694 a, c dbSNP:397507548
1698 1698 a, g dbSNP:374285143
1705 1705 a, c, g dbSNP:397507549
1706 1706 a, c, g dbSNP:121918470
1707 1707 c, g dbSNP:397507550
1710 1710 c, t dbSNP:770457959
1723 1723 a, g dbSNP:773825880
1728 1728 a, g dbSNP:727504377
1752 1752 a, g dbSNP:143801479
1755 1755 c, g dbSNP:777116808
1756 1756 c, t dbSNP:191525506
1757 1757 a, g dbSNP:770363146
1771 1771 a, g dbSNP:587778634
1772 1772 a, g dbSNP:397507551
1785 1785 a, g dbSNP:763597585
1797 1797 c, t dbSNP:587781132
1798 1798 a, g dbSNP:186919241
1803 1803 c, t dbSNP:548648466
1820 1820 c, g dbSNP:759551230
1826 1826 c, t dbSNP:767712281
1827 1827 a, g dbSNP:374896287
1835 1835 c, t dbSNP:148176616
1847 1847 a, g dbSNP:763926088
1848 1848 c, g dbSNP:753741561
1855 1855 c, t dbSNP:397516797
1857 1857 c, t dbSNP:778270727
1859 1859 c, t dbSNP:141140214
1860 1860 a, g dbSNP:397516798
1867 1867 a, t dbSNP:779810329
1873 1873 a, g, t dbSNP:746712068
1874 1874 c, t dbSNP:150730493
1881 1881 c, t dbSNP:749748127
1901 1901 a, g dbSNP:397516799
1903 1903 a, c dbSNP:754106920
1904 1904 a, g dbSNP:781006724
1906 1906 a, g dbSNP:567223058
1910 1910 g, t dbSNP:757593532
1911 1911 a, g dbSNP:779428225
1912 1912 a, g dbSNP:746410911
1917 1917 c, t dbSNP:139188627
1923 1923 c, t dbSNP:397516800
1932 1932 a, g dbSNP:747217473
1943 1943 a, g dbSNP:768805690
1961 1961 -, a dbSNP:773953867
1972 1972 a, g dbSNP:201957261
1975 1975 c, g dbSNP:761625067
2009 2009 c, t dbSNP:730880328
2023 2023 c, g dbSNP:763895470
2028 2028 a, g dbSNP:534038243
2033 2033 c, t dbSNP:753963471
2034 2034 a, g dbSNP:150401860
2042 2042 c, g dbSNP:765423442
2058 2058 a, c dbSNP:567646243
2086 2086 a, g dbSNP:56328752
2087 2087 c, t dbSNP:538274355
2110 2110 a, g dbSNP:750501282
2134 2134 g, t dbSNP:11831567
2145 2145 c, g dbSNP:548110853
2157 2157 c, t dbSNP:577940989
2175 2175 -, c dbSNP:761290107
2237 2237 a, g dbSNP:538914783
2258 2258 c, t dbSNP:190067634
2263 2263 c, t dbSNP:181914703
2264 2264 a, g dbSNP:187361583
2284 2284 a, g dbSNP:192080780
2288 2288 c, t dbSNP:576039073
2340 2340 a, t dbSNP:7138192
2407 2407 c, t dbSNP:372026055
2450 2450 c, g dbSNP:3241
2458 2458 a, g, t dbSNP:3240
2519 2519 -, tg dbSNP:552074590
2616 2616 c, t dbSNP:73209639
2623 2623 c, t dbSNP:59642166
2629 2629 a, g dbSNP:112287134
2636 2636 a, g dbSNP:781589777
2646 2646 c, t dbSNP:748512308
2647 2647 a, g dbSNP:550138781
2672 2672 a, g dbSNP:532463412
2679 2679 c, t dbSNP:770605810
2680 2680 a, g dbSNP:547673624
2733 2733 c, t dbSNP:768178137
2734 2734 a, g dbSNP:181946923
2758 2758 a, g dbSNP:745319452
2760 2760 c, t dbSNP:138246203
2761 2761 a, g dbSNP:753900307
2776 2776 c, t dbSNP:775361295
2797 2797 a, g dbSNP:142648640
2832 2832 a, g dbSNP:760633338
2846 2846 c, t dbSNP:567777121
2850 2850 -, g dbSNP:35137864
2885 2885 a, c dbSNP:763974602
2901 2901 c, t dbSNP:537926588
2930 2930 c, t dbSNP:547853005
2959 2959 c, t dbSNP:776462452
2962 2962 c, t dbSNP:549782052
2964 2964 -, g dbSNP:778240486
2964 2964 c, t dbSNP:571269321
2965 2965 -, g dbSNP:146940557
2974 2974 c, g dbSNP:538946251
2981 2981 c, t dbSNP:554094011
3023 3023 a, g dbSNP:184934232
3044 3044 a, g dbSNP:189739744
3055 3055 c, g dbSNP:554845080
3094 3094 g, t dbSNP:146895091
3114 3114 -, tgatgatga dbSNP:199618935
3114 3114 -, tga dbSNP:148422684
3116 3116 -, tga dbSNP:752248234
3143 3143 a, t dbSNP:543116936
3158 3158 -, atg dbSNP:80269561
3177 3177 a, g dbSNP:558595665
3286 3286 c, g dbSNP:761568292
3333 3333 c, g dbSNP:139266170
3362 3362 a, g dbSNP:377746315
3372 3372 a, c dbSNP:765490519
3482 3482 a, g dbSNP:541018423
3495 3495 c, g, t dbSNP:371375321
3569 3569 a, g dbSNP:750612632
3737 3737 c, t dbSNP:182366345
3764 3764 c, t dbSNP:188162577
3765 3765 a, g dbSNP:766598691
3791 3791 c, t dbSNP:563302019
3835 3835 a, g dbSNP:751729224
3838 3838 g, t dbSNP:191798571
3846 3846 c, t dbSNP:746823887
3893 3893 g, t dbSNP:183574699
3984 3984 a, c, t dbSNP:755522105
4021 4021 a, t dbSNP:571408138
4037 4037 a, g dbSNP:144513512
4055 4055 g, t dbSNP:547373116
4088 4088 a, g dbSNP:188963648
4109 4109 g, t dbSNP:756441720
4124 4124 c, t dbSNP:192434262
4183 4183 c, g dbSNP:555160753
4184 4184 c, t dbSNP:183450083
4203 4203 -, cttga dbSNP:759302517
4258 4258 c, t dbSNP:537146777
4340 4340 a, g dbSNP:770759391
4347 4347 a, c dbSNP:781166352
4355 4355 a, g dbSNP:745822311
4359 4359 c, t dbSNP:769653135
4386 4386 c, t dbSNP:745546287
4392 4392 a, g dbSNP:553718791
4401 4401 a, g dbSNP:775013499
4404 4404 c, t dbSNP:11556500
4407 4407 -, g dbSNP:35369108
4411 4411 a, g dbSNP:186635899
4413 4413 a, t dbSNP:78622120
4461 4461 a, g dbSNP:17849095
4465 4465 c, t dbSNP:577110001
4475 4475 c, t dbSNP:771526838
4496 4496 a, g dbSNP:541055190
4512 4512 a, g dbSNP:373724024
4568 4568 a, g dbSNP:148005691
4588 4588 a, g dbSNP:141655134
4595 4595 a, g dbSNP:371690901
4638 4638 c, t dbSNP:541715735
4648 4648 c, t dbSNP:539696412
4681 4681 c, t dbSNP:145941353
4689 4689 c, t dbSNP:746568122
4690 4690 a, g dbSNP:768622106
4810 4810 c, g dbSNP:76233443
4847 4847 -, a dbSNP:35572550
4872 4872 g, t dbSNP:191451558
4886 4886 a, t dbSNP:190612693
4887 4887 a, t dbSNP:565075386
4954 4954 c, t dbSNP:55853479
4965 4965 a, g dbSNP:141870860
4967 4967 c, g dbSNP:547411598
5002 5002 c, t dbSNP:41307084
5128 5128 a, t dbSNP:530432349
5152 5152 a, g dbSNP:548553622
5190 5190 g, t dbSNP:769489372
5202 5202 c, t dbSNP:773518583
5203 5203 a, g dbSNP:763237386
5227 5227 a, g dbSNP:570319517
5243 5243 c, t dbSNP:542362692
5268 5268 c, t dbSNP:766757908
5283 5283 -, t dbSNP:57848522
5293 5293 c, g dbSNP:139164037
5340 5340 a, g dbSNP:374962107
5351 5351 -, t dbSNP:34105680
5390 5390 c, t dbSNP:751678120
5397 5397 a, c dbSNP:774023322
5456 5456 c, t dbSNP:570581746
5461 5461 a, g dbSNP:149928405
5497 5497 a, t dbSNP:759758035
5499 5499 c, t dbSNP:184174716
5591 5591 c, t dbSNP:552940791
5645 5645 c, t dbSNP:189762784
5753 5753 c, t dbSNP:535425660
5754 5754 a, g dbSNP:557017130
5778 5778 a, g dbSNP:762150907
5789 5789 a, g dbSNP:1985752
5793 5793 g, t dbSNP:575177579
5814 5814 a, t dbSNP:768004889
5823 5823 -, gt dbSNP:556122395
5835 5835 a, g dbSNP:765068888
5857 5857 c, t dbSNP:372268360
5860 5860 a, c, t dbSNP:182289916
5930 5930 a, g dbSNP:572565511
5979 5979 a, g dbSNP:750757268

Target ORF information:

RefSeq Version XM_006719526
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006719526

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAG AAATGGAGCT GTCACCCACA TCAAGATTCA GAACACTGGT
GATTACTATG ACCTGTATGG AGGGGAGAAA TTTGCCACTT TGGCTGAGTT GGTCCAGTAT
TACATGGAAC ATCACGGGCA ATTAAAAGAG AAGAATGGAG ATGTCATTGA GCTTAAATAT
CCTCTGAACT GTGCAGATCC TACCTCTGAA AGGTGGTTTC ATGGACATCT CTCTGGGAAA
GAAGCAGAGA AATTATTAAC TGAAAAAGGA AAACATGGTA GTTTTCTTGT ACGAGAGAGC
CAGAGCCACC CTGGAGATTT TGTTCTTTCT GTGCGCACTG GTGATGACAA AGGGGAGAGC
AATGACGGCA AGTCTAAAGT GACCCATGTT ATGATTCGCT GTCAGGAACT GAAATACGAC
GTTGGTGGAG GAGAACGGTT TGATTCTTTG ACAGATCTTG TGGAACATTA TAAGAAGAAT
CCTATGGTGG AAACATTGGG TACAGTACTA CAACTCAAGC AGCCCCTTAA CACGACTCGT
ATAAATGCTG CTGAAATAGA AAGCAGAGTT CGAGAACTAA GCAAATTAGC TGAGACCACA
GATAAAGTCA AACAAGGCTT TTGGGAAGAA TTTGAGACAC TACAACAACA GGAGTGCAAA
CTTCTCTACA GCCGAAAAGA GGGTCAAAGG CAAGAAAACA AAAACAAAAA TAGATATAAA
AACATCCTGC CCTTTGATCA TACCAGGGTT GTCCTACACG ATGGTGATCC CAATGAGCCT
GTTTCAGATT ACATCAATGC AAATATCATC ATGCCTGAAT TTGAAACCAA GTGCAACAAT
TCAAAGCCCA AAAAGAGTTA CATTGCCACA CAAGGCTGCC TGCAAAACAC GGTGAATGAC
TTTTGGCGGA TGGTGTTCCA AGAAAACTCC CGAGTGATTG TCATGACAAC GAAAGAAGTG
GAGAGAGGAA AGAGTAAATG TGTCAAATAC TGGCCTGATG AGTATGCTCT AAAAGAATAT
GGCGTCATGC GTGTTAGGAA CGTCAAAGAA AGCGCCGCTC ATGACTATAC GCTAAGAGAA
CTTAAACTTT CAAAGGTTGG ACAAGCTCTA CTCCAGGGGA ATACGGAGAG AACGGTCTGG
CAATACCACT TTCGGACCTG GCCGGACCAC GGCGTGCCCA GCGACCCTGG GGGCGTGCTG
GACTTCCTGG AGGAGGTGCA CCATAAGCAG GAGAGCATCA TGGATGCAGG GCCGGTCGTG
GTGCACTGCA GTGCTGGAAT TGGCCGGACA GGGACGTTCA TTGTGATTGA TATTCTTATT
GACATCATCA GAGAGAAAGG TGTTGACTGC GATATTGACG TTCCCAAAAC CATCCAGATG
GTGCGGTCTC AGAGGTCAGG GATGGTCCAG ACAGAAGCAC AGTACCGATT TATCTATATG
GCGGTCCAGC ATTATATTGA AACACTACAG CGCAGGATTG AAGAAGAGCA GAAAAGCAAG
AGGAAAGGGC ACGAATATAC AAATATTAAG TATTCTCTAG CGGACCAGAC GAGTGGAGAT
CAGAGCCCTC TCCCGCCTTG TACTCCAACG CCACCCTGTG CAGAAATGAG AGAAGACAGT
GCTAGAGTCT ATGAAAACGT GGGCCTGATG CAACAGCAGA AAAGTTTCAG ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60047
Accession Version XM_011538613.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1791bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product tyrosine-protein phosphatase non-receptor type 11 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_029419.13) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAA TGGAGCTGTC ACCCACATCA AGATTCAGAA CACTGGTGAT
TACTATGACC TGTATGGAGG GGAGAAATTT GCCACTTTGG CTGAGTTGGT CCAGTATTAC
ATGGAACATC ACGGGCAATT AAAAGAGAAG AATGGAGATG TCATTGAGCT TAAATATCCT
CTGAACTGTG CAGATCCTAC CTCTGAAAGG TGGTTTCATG GACATCTCTC TGGGAAAGAA
GCAGAGAAAT TATTAACTGA AAAAGGAAAA CATGGTAGTT TTCTTGTACG AGAGAGCCAG
AGCCACCCTG GAGATTTTGT TCTTTCTGTG CGCACTGGTG ATGACAAAGG GGAGAGCAAT
GACGGCAAGT CTAAAGTGAC CCATGTTATG ATTCGCTGTC AGGAACTGAA ATACGACGTT
GGTGGAGGAG AACGGTTTGA TTCTTTGACA GATCTTGTGG AACATTATAA GAAGAATCCT
ATGGTGGAAA CATTGGGTAC AGTACTACAA CTCAAGCAGC CCCTTAACAC GACTCGTATA
AATGCTGCTG AAATAGAAAG CAGAGTTCGA GAACTAAGCA AATTAGCTGA GACCACAGAT
AAAGTCAAAC AAGGCTTTTG GGAAGAATTT GAGACACTAC AACAACAGGA GTGCAAACTT
CTCTACAGCC GAAAAGAGGG TCAAAGGCAA GAAAACAAAA ACAAAAATAG ATATAAAAAC
ATCCTGCCCT TTGATCATAC CAGGGTTGTC CTACACGATG GTGATCCCAA TGAGCCTGTT
TCAGATTACA TCAATGCAAA TATCATCATG CCTGAATTTG AAACCAAGTG CAACAATTCA
AAGCCCAAAA AGAGTTACAT TGCCACACAA GGCTGCCTGC AAAACACGGT GAATGACTTT
TGGCGGATGG TGTTCCAAGA AAACTCCCGA GTGATTGTCA TGACAACGAA AGAAGTGGAG
AGAGGAAAGA GTAAATGTGT CAAATACTGG CCTGATGAGT ATGCTCTAAA AGAATATGGC
GTCATGCGTG TTAGGAACGT CAAAGAAAGC GCCGCTCATG ACTATACGCT AAGAGAACTT
AAACTTTCAA AGGTTGGACA AGCTCTACTC CAGGGGAATA CGGAGAGAAC GGTCTGGCAA
TACCACTTTC GGACCTGGCC GGACCACGGC GTGCCCAGCG ACCCTGGGGG CGTGCTGGAC
TTCCTGGAGG AGGTGCACCA TAAGCAGGAG AGCATCATGG ATGCAGGGCC GGTCGTGGTG
CACTGCAGTG CTGGAATTGG CCGGACAGGG ACGTTCATTG TGATTGATAT TCTTATTGAC
ATCATCAGAG AGAAAGGTGT TGACTGCGAT ATTGACGTTC CCAAAACCAT CCAGATGGTG
CGGTCTCAGA GGTCAGGGAT GGTCCAGACA GAAGCACAGT ACCGATTTAT CTATATGGCG
GTCCAGCATT ATATTGAAAC ACTACAGCGC AGGATTGAAG AAGAGCAGAA AAGCAAGAGG
AAAGGGCACG AATATACAAA TATTAAGTAT TCTCTAGCGG ACCAGACGAG TGGAGATCAG
AGCCCTCTCC CGCCTTGTAC TCCAACGCCA CCCTGTGCAG AAATGAGAGA AGACAGTGCT
AGAGTCTATG AAAACGTGGG CCTGATGCAA CAGCAGAAAA GTTTCAGATG A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011536915.1
CDS201..1991
Misc Feature(1)213..506(+)
Misc Feature(2)237..362(+)
Misc Feature(3)351..476(+)
Misc Feature(4)528..851(+)
Misc Feature(5)612..638(+)
Misc Feature(6)705..788(+)
Misc Feature(7)933..1769(+)
Misc Feature(8)1023..1766(+)
Misc Feature(9)1482..1607(+)
Translation
Position Chain Variation Link
14 14 c, g dbSNP:562614931
21 21 a, g dbSNP:149766959
22 22 g, t dbSNP:545369072
29 29 g, t dbSNP:532311943
34 34 a, g dbSNP:560323658
66 66 a, g dbSNP:527982856
80 80 g, t dbSNP:554487214
99 99 c, t dbSNP:567977545
111 111 a, g dbSNP:531915358
124 124 a, g dbSNP:766412799
141 141 g, t dbSNP:550428179
156 156 g, t dbSNP:587781131
174 174 a, g dbSNP:375495669
188 188 a, g dbSNP:760374212
205 205 c, t dbSNP:267606990
206 206 a, g dbSNP:768238710
213 213 a, g dbSNP:587781133
218 218 g, t dbSNP:79203122
225 225 c, g dbSNP:566068139
226 226 a, c dbSNP:536503257
228 228 a, g dbSNP:368633510
229 229 a, g dbSNP:200613531
236 236 c, t dbSNP:760086740
248 248 a, g dbSNP:372736227
252 252 a, g dbSNP:776089364
253 253 a, g dbSNP:587778635
256 256 g, t dbSNP:397507500
257 257 a, g dbSNP:764238610
258 258 c, g dbSNP:753951666
264 264 a, g dbSNP:757537175
266 266 a, g dbSNP:397516808
276 276 a, g dbSNP:750261927
314 314 g, t dbSNP:758209360
317 317 a, c dbSNP:779813529
319 319 a, g dbSNP:397516795
324 324 a, g dbSNP:397507501
332 332 a, c, t dbSNP:397507502
340 340 a, g dbSNP:765495843
345 345 a, g dbSNP:587778636
352 352 c, t dbSNP:397507503
353 353 c, t dbSNP:147388185
356 356 c, t dbSNP:766205831
363 363 a, g dbSNP:397507504
369 369 a, c, g, t dbSNP:397507505
370 370 a, g dbSNP:751437780
371 371 a, c, g dbSNP:397507506
375 375 -, ggt dbSNP:121918471
375 375 a, g, t dbSNP:397507507
376 376 gtga, t dbSNP:397507508
376 376 -, gtg dbSNP:80338836
376 376 c, g, t dbSNP:397507509
378 378 a, c, g dbSNP:397507510
379 379 a, c, g, t dbSNP:121918461
381 381 a, g, t dbSNP:121918460
385 385 a, g dbSNP:121918459
402 402 c, g dbSNP:397507511
403 403 a, t dbSNP:727503380
406 406 a, g dbSNP:397516801
408 408 c, g, t dbSNP:397507512
409 409 g, t dbSNP:755709231
411 411 a, c, g, t dbSNP:121918453
412 412 c, g, t dbSNP:121918454
413 413 c, t dbSNP:777529056
414 414 ac, ct dbSNP:397516802
414 414 a, c dbSNP:397507513
415 415 c, t dbSNP:121918462
423 423 a, c, g dbSNP:121918464
424 424 a, c, g, t dbSNP:121918465
425 425 c, g, t dbSNP:397507514
432 432 a, c dbSNP:397516803
433 433 a, g dbSNP:121918466
434 434 c, g dbSNP:748952554
441 441 a, g dbSNP:397507515
443 443 a, g dbSNP:753788277
452 452 c, t dbSNP:61736914
486 486 c, g dbSNP:397507516
492 492 a, t dbSNP:387907158
498 498 c, g dbSNP:747470140
507 507 c, t dbSNP:747300372
512 512 a, t dbSNP:397516804
514 514 a, c dbSNP:397507517
525 525 a, g dbSNP:397507518
526 526 a, c dbSNP:397507519
550 550 -, ct dbSNP:398122859
566 566 a, g, t dbSNP:755619262
573 573 c, t dbSNP:146497890
578 578 c, t dbSNP:757004128
587 587 a, g dbSNP:542711611
589 589 a, g dbSNP:397516805
606 606 -, gtacg dbSNP:398122857
609 609 c, t dbSNP:267606989
614 614 c, g, t dbSNP:397507520
623 623 c, t dbSNP:199498784
629 629 c, t dbSNP:758194931
648 648 c, g dbSNP:768927453
649 649 c, t dbSNP:202026962
652 652 a, g dbSNP:397507521
655 655 aagaacacaggggagagca, ctggtg dbSNP:398122858
658 658 c, g dbSNP:376027245
664 664 a, g dbSNP:200712424
674 674 c, g dbSNP:769848611
683 683 c, t dbSNP:397507522
684 684 a, g dbSNP:730880992
692 692 a, t dbSNP:771233518
714 714 c, t dbSNP:545138829
715 715 a, g, t dbSNP:369155025
716 716 c, g dbSNP:767425313
725 725 a, g dbSNP:775493749
726 726 c, g dbSNP:760660964
734 734 c, t dbSNP:141015445
737 737 c, t dbSNP:753269427
753 753 c, t dbSNP:143433437
754 754 a, g dbSNP:764663951
755 755 g, t dbSNP:200920312
762 762 g, t dbSNP:79068130
769 769 a, c, g dbSNP:370763866
782 782 a, c dbSNP:753107691
788 788 g, t dbSNP:76982592
791 791 a, g dbSNP:778211349
795 795 a, t dbSNP:727503381
813 813 c, t dbSNP:78376169
818 818 c, t dbSNP:757304894
827 827 a, g dbSNP:778919108
829 829 a, t dbSNP:745331641
848 848 c, g dbSNP:747243342
849 849 a, g dbSNP:768555552
851 851 a, g dbSNP:568340391
856 856 a, g dbSNP:780911423
858 858 -, a dbSNP:397516807
858 858 a, g, t dbSNP:397516806
880 880 g, t dbSNP:748085966
898 898 a, g dbSNP:730881220
914 914 c, g dbSNP:138215269
954 954 a, g dbSNP:773918720
959 959 a, g dbSNP:745489506
960 960 c, t dbSNP:771672596
964 964 a, g dbSNP:397507523
965 965 a, g dbSNP:775232682
967 967 -, aca dbSNP:397507524
971 971 g, t dbSNP:397516809
976 976 a, g dbSNP:773417679
978 978 c, t dbSNP:397507525
979 979 a, t dbSNP:765642157
982 982 a, g, t dbSNP:397507526
985 985 a, g dbSNP:763617831
990 990 a, c dbSNP:766531368
991 991 a, g dbSNP:376607329
998 998 g, t dbSNP:755104848
999 999 a, g, t dbSNP:397507527
1011 1011 a, g dbSNP:752966396
1021 1021 a, c dbSNP:397507528
1024 1024 a, g dbSNP:777603059
1029 1029 a, c dbSNP:749220083
1031 1031 a, g dbSNP:757228212
1033 1033 a, c, g dbSNP:121918456
1041 1041 a, g dbSNP:397507529
1043 1043 c, g dbSNP:397507530
1044 1044 a, c dbSNP:778374689
1049 1049 c, t dbSNP:571488248
1050 1050 c, g, t dbSNP:397507531
1051 1051 a, c, g, t dbSNP:121918463
1052 1052 g, t dbSNP:397516810
1055 1055 a, t dbSNP:397516811
1076 1076 c, g, t dbSNP:117730996
1077 1077 a, g dbSNP:376007642
1078 1078 a, g dbSNP:746607246
1090 1090 a, g dbSNP:572274623
1094 1094 a, g dbSNP:781010979
1110 1110 a, g dbSNP:730880995
1118 1118 a, g dbSNP:202019810
1119 1119 a, g dbSNP:28933386
1120 1120 a, c, g dbSNP:121918455
1122 1122 a, g dbSNP:201787206
1128 1128 a, g dbSNP:774939392
1129 1129 c, t dbSNP:201226824
1136 1136 a, g dbSNP:751028422
1144 1144 c, t dbSNP:547041954
1148 1148 a, g dbSNP:576405446
1150 1150 a, g dbSNP:747815170
1154 1154 c, t dbSNP:771407775
1164 1164 c, t dbSNP:779400765
1166 1166 a, c dbSNP:746329572
1168 1168 a, g dbSNP:772684421
1180 1180 c, t dbSNP:369430257
1182 1182 a, g dbSNP:760769867
1187 1187 a, c dbSNP:369739920
1193 1193 c, t dbSNP:397507533
1194 1194 a, t dbSNP:730880993
1208 1208 a, c, g dbSNP:371951288
1220 1220 c, t dbSNP:762516252
1225 1225 a, g dbSNP:535800148
1238 1238 a, g dbSNP:766297596
1245 1245 g, t dbSNP:146571700
1249 1249 a, g dbSNP:397507534
1250 1250 a, g dbSNP:190776554
1251 1251 c, g dbSNP:767192602
1254 1254 a, c dbSNP:752392909
1266 1266 a, g dbSNP:755871216
1268 1268 a, g dbSNP:779125362
1299 1299 a, g dbSNP:758737605
1317 1317 c, g dbSNP:397507535
1318 1318 a, g dbSNP:780328721
1321 1321 a, g dbSNP:41299183
1328 1328 a, c dbSNP:370059077
1340 1340 c, t dbSNP:781677115
1347 1347 c, t dbSNP:748162361
1350 1350 a, g dbSNP:769798916
1358 1358 c, t dbSNP:727505180
1359 1359 a, g dbSNP:749523268
1370 1370 c, t dbSNP:770730416
1371 1371 a, g dbSNP:774356443
1373 1373 c, t dbSNP:759533871
1387 1387 c, t dbSNP:767503386
1388 1388 a, g dbSNP:775571445
1414 1414 c, t dbSNP:760221298
1418 1418 a, g dbSNP:532529560
1422 1422 c, g, t dbSNP:779291780
1424 1424 c, t dbSNP:772022775
1425 1425 c, g dbSNP:377257792
1427 1427 a, g dbSNP:727504397
1435 1435 c, g dbSNP:201247699
1441 1441 a, c, t dbSNP:121918467
1447 1447 a, g dbSNP:761510407
1451 1451 c, g, t dbSNP:552394167
1475 1475 c, g dbSNP:759848374
1481 1481 a, g dbSNP:767920323
1486 1486 a, c dbSNP:727505389
1490 1490 c, t dbSNP:753173299
1491 1491 a, g dbSNP:397507536
1494 1494 c, t dbSNP:756647576
1505 1505 g, t dbSNP:150524715
1511 1511 c, t dbSNP:777895575
1517 1517 a, g dbSNP:753803665
1520 1520 c, t dbSNP:757362412
1524 1524 -, c dbSNP:398122860
1536 1536 c, t dbSNP:779236638
1554 1554 a, g dbSNP:746112827
1571 1571 a, g dbSNP:771967829
1575 1575 a, g, t dbSNP:397516796
1583 1583 a, c dbSNP:727504393
1590 1590 a, g, t dbSNP:121918468
1591 1591 c, g dbSNP:397509344
1600 1600 c, g dbSNP:121918469
1611 1611 a, c dbSNP:397507537
1612 1612 c, t dbSNP:121918457
1613 1613 c, g dbSNP:587781130
1617 1617 a, g dbSNP:779978269
1634 1634 c, t dbSNP:746719818
1640 1640 c, t dbSNP:139196273
1648 1648 a, g dbSNP:754837922
1649 1649 a, g dbSNP:780946087
1658 1658 g, t dbSNP:143238917
1662 1662 g, t dbSNP:397507538
1667 1667 c, t dbSNP:751834261
1669 1669 a, g dbSNP:730880994
1676 1676 c, t dbSNP:539373294
1677 1677 a, g dbSNP:781083623
1680 1680 a, c, g, t dbSNP:397507539
1681 1681 a, c, t dbSNP:397507540
1692 1692 c, g dbSNP:756104635
1701 1701 c, t dbSNP:397507541
1702 1702 g, t dbSNP:397507542
1711 1711 a, g dbSNP:397507543
1713 1713 a, g, t dbSNP:121918458
1714 1714 c, t dbSNP:397507544
1716 1716 a, c, g dbSNP:397507545
1717 1717 a, c, g, t dbSNP:397507546
1719 1719 a, g dbSNP:397507547
1725 1725 c, t dbSNP:387907157
1726 1726 ag, cc dbSNP:397509345
1726 1726 a, c dbSNP:397507548
1730 1730 a, g dbSNP:374285143
1737 1737 a, c, g dbSNP:397507549
1738 1738 a, c, g dbSNP:121918470
1739 1739 c, g dbSNP:397507550
1742 1742 c, t dbSNP:770457959
1755 1755 a, g dbSNP:773825880
1760 1760 a, g dbSNP:727504377
1784 1784 a, g dbSNP:143801479
1787 1787 c, g dbSNP:777116808
1788 1788 c, t dbSNP:191525506
1789 1789 a, g dbSNP:770363146
1803 1803 a, g dbSNP:587778634
1804 1804 a, g dbSNP:397507551
1817 1817 a, g dbSNP:763597585
1829 1829 c, t dbSNP:587781132
1830 1830 a, g dbSNP:186919241
1835 1835 c, t dbSNP:548648466
1852 1852 c, g dbSNP:759551230
1858 1858 c, t dbSNP:767712281
1859 1859 a, g dbSNP:374896287
1867 1867 c, t dbSNP:148176616
1879 1879 a, g dbSNP:763926088
1880 1880 c, g dbSNP:753741561
1887 1887 c, t dbSNP:397516797
1889 1889 c, t dbSNP:778270727
1891 1891 c, t dbSNP:141140214
1892 1892 a, g dbSNP:397516798
1899 1899 a, t dbSNP:779810329
1905 1905 a, g, t dbSNP:746712068
1906 1906 c, t dbSNP:150730493
1913 1913 c, t dbSNP:749748127
1933 1933 a, g dbSNP:397516799
1935 1935 a, c dbSNP:754106920
1936 1936 a, g dbSNP:781006724
1938 1938 a, g dbSNP:567223058
1942 1942 g, t dbSNP:757593532
1943 1943 a, g dbSNP:779428225
1944 1944 a, g dbSNP:746410911
1949 1949 c, t dbSNP:139188627
1955 1955 c, t dbSNP:397516800
1964 1964 a, g dbSNP:747217473
1975 1975 a, g dbSNP:768805690
1993 1993 -, a dbSNP:773953867
2004 2004 a, g dbSNP:201957261
2007 2007 c, g dbSNP:761625067
2041 2041 c, t dbSNP:730880328
2055 2055 c, g dbSNP:763895470
2060 2060 a, g dbSNP:534038243
2065 2065 c, t dbSNP:753963471
2066 2066 a, g dbSNP:150401860
2074 2074 c, g dbSNP:765423442
2090 2090 a, c dbSNP:567646243
2118 2118 a, g dbSNP:56328752
2119 2119 c, t dbSNP:538274355
2142 2142 a, g dbSNP:750501282
2166 2166 g, t dbSNP:11831567
2177 2177 c, g dbSNP:548110853
2189 2189 c, t dbSNP:577940989
2207 2207 -, c dbSNP:761290107
2269 2269 a, g dbSNP:538914783
2290 2290 c, t dbSNP:190067634
2295 2295 c, t dbSNP:181914703
2296 2296 a, g dbSNP:187361583
2316 2316 a, g dbSNP:192080780
2320 2320 c, t dbSNP:576039073
2372 2372 a, t dbSNP:7138192
2439 2439 c, t dbSNP:372026055
2482 2482 c, g dbSNP:3241
2490 2490 a, g, t dbSNP:3240
2551 2551 -, tg dbSNP:552074590
2648 2648 c, t dbSNP:73209639
2655 2655 c, t dbSNP:59642166
2661 2661 a, g dbSNP:112287134
2668 2668 a, g dbSNP:781589777
2678 2678 c, t dbSNP:748512308
2679 2679 a, g dbSNP:550138781
2704 2704 a, g dbSNP:532463412
2711 2711 c, t dbSNP:770605810
2712 2712 a, g dbSNP:547673624
2765 2765 c, t dbSNP:768178137
2766 2766 a, g dbSNP:181946923
2790 2790 a, g dbSNP:745319452
2792 2792 c, t dbSNP:138246203
2793 2793 a, g dbSNP:753900307
2808 2808 c, t dbSNP:775361295
2829 2829 a, g dbSNP:142648640
2864 2864 a, g dbSNP:760633338
2878 2878 c, t dbSNP:567777121
2882 2882 -, g dbSNP:35137864
2917 2917 a, c dbSNP:763974602
2933 2933 c, t dbSNP:537926588
2962 2962 c, t dbSNP:547853005
2991 2991 c, t dbSNP:776462452
2994 2994 c, t dbSNP:549782052
2996 2996 -, g dbSNP:778240486
2996 2996 c, t dbSNP:571269321
2997 2997 -, g dbSNP:146940557
3006 3006 c, g dbSNP:538946251
3013 3013 c, t dbSNP:554094011
3055 3055 a, g dbSNP:184934232
3076 3076 a, g dbSNP:189739744
3087 3087 c, g dbSNP:554845080
3126 3126 g, t dbSNP:146895091
3146 3146 -, tgatgatga dbSNP:199618935
3146 3146 -, tga dbSNP:148422684
3148 3148 -, tga dbSNP:752248234
3175 3175 a, t dbSNP:543116936
3190 3190 -, atg dbSNP:80269561
3209 3209 a, g dbSNP:558595665
3318 3318 c, g dbSNP:761568292
3365 3365 c, g dbSNP:139266170
3394 3394 a, g dbSNP:377746315
3404 3404 a, c dbSNP:765490519
3514 3514 a, g dbSNP:541018423
3527 3527 c, g, t dbSNP:371375321
3601 3601 a, g dbSNP:750612632
3769 3769 c, t dbSNP:182366345
3796 3796 c, t dbSNP:188162577
3797 3797 a, g dbSNP:766598691
3823 3823 c, t dbSNP:563302019
3867 3867 a, g dbSNP:751729224
3870 3870 g, t dbSNP:191798571
3878 3878 c, t dbSNP:746823887
3925 3925 g, t dbSNP:183574699
4016 4016 a, c, t dbSNP:755522105
4053 4053 a, t dbSNP:571408138
4069 4069 a, g dbSNP:144513512
4087 4087 g, t dbSNP:547373116
4120 4120 a, g dbSNP:188963648
4141 4141 g, t dbSNP:756441720
4156 4156 c, t dbSNP:192434262
4215 4215 c, g dbSNP:555160753
4216 4216 c, t dbSNP:183450083
4235 4235 -, cttga dbSNP:759302517
4290 4290 c, t dbSNP:537146777
4372 4372 a, g dbSNP:770759391
4379 4379 a, c dbSNP:781166352
4387 4387 a, g dbSNP:745822311
4391 4391 c, t dbSNP:769653135
4418 4418 c, t dbSNP:745546287
4424 4424 a, g dbSNP:553718791
4433 4433 a, g dbSNP:775013499
4436 4436 c, t dbSNP:11556500
4439 4439 -, g dbSNP:35369108
4443 4443 a, g dbSNP:186635899
4445 4445 a, t dbSNP:78622120
4493 4493 a, g dbSNP:17849095
4497 4497 c, t dbSNP:577110001
4507 4507 c, t dbSNP:771526838
4528 4528 a, g dbSNP:541055190
4544 4544 a, g dbSNP:373724024
4600 4600 a, g dbSNP:148005691
4620 4620 a, g dbSNP:141655134
4627 4627 a, g dbSNP:371690901
4670 4670 c, t dbSNP:541715735
4680 4680 c, t dbSNP:539696412
4713 4713 c, t dbSNP:145941353
4721 4721 c, t dbSNP:746568122
4722 4722 a, g dbSNP:768622106
4842 4842 c, g dbSNP:76233443
4879 4879 -, a dbSNP:35572550
4904 4904 g, t dbSNP:191451558
4918 4918 a, t dbSNP:190612693
4919 4919 a, t dbSNP:565075386
4986 4986 c, t dbSNP:55853479
4997 4997 a, g dbSNP:141870860
4999 4999 c, g dbSNP:547411598
5034 5034 c, t dbSNP:41307084
5160 5160 a, t dbSNP:530432349
5184 5184 a, g dbSNP:548553622
5222 5222 g, t dbSNP:769489372
5234 5234 c, t dbSNP:773518583
5235 5235 a, g dbSNP:763237386
5259 5259 a, g dbSNP:570319517
5275 5275 c, t dbSNP:542362692
5300 5300 c, t dbSNP:766757908
5315 5315 -, t dbSNP:57848522
5325 5325 c, g dbSNP:139164037
5372 5372 a, g dbSNP:374962107
5383 5383 -, t dbSNP:34105680
5422 5422 c, t dbSNP:751678120
5429 5429 a, c dbSNP:774023322
5488 5488 c, t dbSNP:570581746
5493 5493 a, g dbSNP:149928405
5529 5529 a, t dbSNP:759758035
5531 5531 c, t dbSNP:184174716
5623 5623 c, t dbSNP:552940791
5677 5677 c, t dbSNP:189762784
5785 5785 c, t dbSNP:535425660
5786 5786 a, g dbSNP:557017130
5810 5810 a, g dbSNP:762150907
5821 5821 a, g dbSNP:1985752
5825 5825 g, t dbSNP:575177579
5846 5846 a, t dbSNP:768004889
5855 5855 -, gt dbSNP:556122395
5867 5867 a, g dbSNP:765068888
5889 5889 c, t dbSNP:372268360
5892 5892 a, c, t dbSNP:182289916
5962 5962 a, g dbSNP:572565511
6011 6011 a, g dbSNP:750757268

Target ORF information:

RefSeq Version XM_011538613
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011538613

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAA TGGAGCTGTC ACCCACATCA AGATTCAGAA CACTGGTGAT
TACTATGACC TGTATGGAGG GGAGAAATTT GCCACTTTGG CTGAGTTGGT CCAGTATTAC
ATGGAACATC ACGGGCAATT AAAAGAGAAG AATGGAGATG TCATTGAGCT TAAATATCCT
CTGAACTGTG CAGATCCTAC CTCTGAAAGG TGGTTTCATG GACATCTCTC TGGGAAAGAA
GCAGAGAAAT TATTAACTGA AAAAGGAAAA CATGGTAGTT TTCTTGTACG AGAGAGCCAG
AGCCACCCTG GAGATTTTGT TCTTTCTGTG CGCACTGGTG ATGACAAAGG GGAGAGCAAT
GACGGCAAGT CTAAAGTGAC CCATGTTATG ATTCGCTGTC AGGAACTGAA ATACGACGTT
GGTGGAGGAG AACGGTTTGA TTCTTTGACA GATCTTGTGG AACATTATAA GAAGAATCCT
ATGGTGGAAA CATTGGGTAC AGTACTACAA CTCAAGCAGC CCCTTAACAC GACTCGTATA
AATGCTGCTG AAATAGAAAG CAGAGTTCGA GAACTAAGCA AATTAGCTGA GACCACAGAT
AAAGTCAAAC AAGGCTTTTG GGAAGAATTT GAGACACTAC AACAACAGGA GTGCAAACTT
CTCTACAGCC GAAAAGAGGG TCAAAGGCAA GAAAACAAAA ACAAAAATAG ATATAAAAAC
ATCCTGCCCT TTGATCATAC CAGGGTTGTC CTACACGATG GTGATCCCAA TGAGCCTGTT
TCAGATTACA TCAATGCAAA TATCATCATG CCTGAATTTG AAACCAAGTG CAACAATTCA
AAGCCCAAAA AGAGTTACAT TGCCACACAA GGCTGCCTGC AAAACACGGT GAATGACTTT
TGGCGGATGG TGTTCCAAGA AAACTCCCGA GTGATTGTCA TGACAACGAA AGAAGTGGAG
AGAGGAAAGA GTAAATGTGT CAAATACTGG CCTGATGAGT ATGCTCTAAA AGAATATGGC
GTCATGCGTG TTAGGAACGT CAAAGAAAGC GCCGCTCATG ACTATACGCT AAGAGAACTT
AAACTTTCAA AGGTTGGACA AGCTCTACTC CAGGGGAATA CGGAGAGAAC GGTCTGGCAA
TACCACTTTC GGACCTGGCC GGACCACGGC GTGCCCAGCG ACCCTGGGGG CGTGCTGGAC
TTCCTGGAGG AGGTGCACCA TAAGCAGGAG AGCATCATGG ATGCAGGGCC GGTCGTGGTG
CACTGCAGTG CTGGAATTGG CCGGACAGGG ACGTTCATTG TGATTGATAT TCTTATTGAC
ATCATCAGAG AGAAAGGTGT TGACTGCGAT ATTGACGTTC CCAAAACCAT CCAGATGGTG
CGGTCTCAGA GGTCAGGGAT GGTCCAGACA GAAGCACAGT ACCGATTTAT CTATATGGCG
GTCCAGCATT ATATTGAAAC ACTACAGCGC AGGATTGAAG AAGAGCAGAA AAGCAAGAGG
AAAGGGCACG AATATACAAA TATTAAGTAT TCTCTAGCGG ACCAGACGAG TGGAGATCAG
AGCCCTCTCC CGCCTTGTAC TCCAACGCCA CCCTGTGCAG AAATGAGAGA AGACAGTGCT
AGAGTCTATG AAAACGTGGG CCTGATGCAA CAGCAGAAAA GTTTCAGATG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu46741
Accession Version XM_006719527.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1680bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product tyrosine-protein phosphatase non-receptor type 11 isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_029419.13) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAG AAATGGAGCT GTCACCCACA TCAAGATTCA GAACACTGGT
GATTACTATG ACCTGTATGG AGGGGAGAAA TTTGCCACTT TGGCTGAGTT GGTCCAGTAT
TACATGGAAC ATCACGGGCA ATTAAAAGAG AAGAATGGAG ATGTCATTGA GCTTAAATAT
CCTCTGAACT GTGCAGATCC TACCTCTGAA AGGTGGTTTC ATGGACATCT CTCTGGGAAA
GAAGCAGAGA AATTATTAAC TGAAAAAGGA AAACATGGTA GTTTTCTTGT ACGAGAGAGC
CAGAGCCACC CTGGAGATTT TGTTCTTTCT GTGCGCACTG GTGATGACAA AGGGGAGAGC
AATGACGGCA AGTCTAAAGT GACCCATGTT ATGATTCGCT GTCAGGAACT GAAATACGAC
GTTGGTGGAG GAGAACGGTT TGATTCTTTG ACAGATCTTG TGGAACATTA TAAGAAGAAT
CCTATGGTGG AAACATTGGG TACAGTACTA CAACTCAAGC AGACACTACA ACAACAGGAG
TGCAAACTTC TCTACAGCCG AAAAGAGGGT CAAAGGCAAG AAAACAAAAA CAAAAATAGA
TATAAAAACA TCCTGCCCTT TGATCATACC AGGGTTGTCC TACACGATGG TGATCCCAAT
GAGCCTGTTT CAGATTACAT CAATGCAAAT ATCATCATGC CTGAATTTGA AACCAAGTGC
AACAATTCAA AGCCCAAAAA GAGTTACATT GCCACACAAG GCTGCCTGCA AAACACGGTG
AATGACTTTT GGCGGATGGT GTTCCAAGAA AACTCCCGAG TGATTGTCAT GACAACGAAA
GAAGTGGAGA GAGGAAAGAG TAAATGTGTC AAATACTGGC CTGATGAGTA TGCTCTAAAA
GAATATGGCG TCATGCGTGT TAGGAACGTC AAAGAAAGCG CCGCTCATGA CTATACGCTA
AGAGAACTTA AACTTTCAAA GGTTGGACAA GCTCTACTCC AGGGGAATAC GGAGAGAACG
GTCTGGCAAT ACCACTTTCG GACCTGGCCG GACCACGGCG TGCCCAGCGA CCCTGGGGGC
GTGCTGGACT TCCTGGAGGA GGTGCACCAT AAGCAGGAGA GCATCATGGA TGCAGGGCCG
GTCGTGGTGC ACTGCAGTGC TGGAATTGGC CGGACAGGGA CGTTCATTGT GATTGATATT
CTTATTGACA TCATCAGAGA GAAAGGTGTT GACTGCGATA TTGACGTTCC CAAAACCATC
CAGATGGTGC GGTCTCAGAG GTCAGGGATG GTCCAGACAG AAGCACAGTA CCGATTTATC
TATATGGCGG TCCAGCATTA TATTGAAACA CTACAGCGCA GGATTGAAGA AGAGCAGAAA
AGCAAGAGGA AAGGGCACGA ATATACAAAT ATTAAGTATT CTCTAGCGGA CCAGACGAGT
GGAGATCAGA GCCCTCTCCC GCCTTGTACT CCAACGCCAC CCTGTGCAGA AATGAGAGAA
GACAGTGCTA GAGTCTATGA AAACGTGGGC CTGATGCAAC AGCAGAAAAG TTTCAGATGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_006719590.1
CDS166..1845
Misc Feature(1)178..474(+)
Misc Feature(2)202..330(+)
Misc Feature(3)319..444(+)
Misc Feature(4)496..792(+)
Misc Feature(5)580..606(+)
Misc Feature(6)673..756(+)
Misc Feature(7)841..1623(+)
Misc Feature(8)877..1620(+)
Misc Feature(9)1336..1461(+)
Translation
Position Chain Variation Link
31 31 a, g dbSNP:527982856
45 45 g, t dbSNP:554487214
64 64 c, t dbSNP:567977545
76 76 a, g dbSNP:531915358
89 89 a, g dbSNP:766412799
106 106 g, t dbSNP:550428179
121 121 g, t dbSNP:587781131
139 139 a, g dbSNP:375495669
153 153 a, g dbSNP:760374212
170 170 c, t dbSNP:267606990
171 171 a, g dbSNP:768238710
178 178 a, g dbSNP:587781133
183 183 g, t dbSNP:79203122
190 190 c, g dbSNP:566068139
191 191 a, c dbSNP:536503257
193 193 a, g dbSNP:368633510
194 194 a, g dbSNP:200613531
201 201 c, t dbSNP:760086740
213 213 a, g dbSNP:372736227
217 217 a, g dbSNP:776089364
218 218 a, g dbSNP:587778635
221 221 g, t dbSNP:397507500
222 222 a, g dbSNP:764238610
223 223 c, g dbSNP:753951666
229 229 a, g dbSNP:757537175
231 231 a, g dbSNP:397516808
241 241 a, g dbSNP:750261927
279 279 g, t dbSNP:758209360
282 282 a, c dbSNP:779813529
284 284 a, g dbSNP:397516795
289 289 a, g dbSNP:397507501
297 297 a, c, t dbSNP:397507502
308 308 a, g dbSNP:765495843
313 313 a, g dbSNP:587778636
320 320 c, t dbSNP:397507503
321 321 c, t dbSNP:147388185
324 324 c, t dbSNP:766205831
331 331 a, g dbSNP:397507504
337 337 a, c, g, t dbSNP:397507505
338 338 a, g dbSNP:751437780
339 339 a, c, g dbSNP:397507506
343 343 -, ggt dbSNP:121918471
343 343 a, g, t dbSNP:397507507
344 344 gtga, t dbSNP:397507508
344 344 -, gtg dbSNP:80338836
344 344 c, g, t dbSNP:397507509
346 346 a, c, g dbSNP:397507510
347 347 a, c, g, t dbSNP:121918461
349 349 a, g, t dbSNP:121918460
353 353 a, g dbSNP:121918459
370 370 c, g dbSNP:397507511
371 371 a, t dbSNP:727503380
374 374 a, g dbSNP:397516801
376 376 c, g, t dbSNP:397507512
377 377 g, t dbSNP:755709231
379 379 a, c, g, t dbSNP:121918453
380 380 c, g, t dbSNP:121918454
381 381 c, t dbSNP:777529056
382 382 ac, ct dbSNP:397516802
382 382 a, c dbSNP:397507513
383 383 c, t dbSNP:121918462
391 391 a, c, g dbSNP:121918464
392 392 a, c, g, t dbSNP:121918465
393 393 c, g, t dbSNP:397507514
400 400 a, c dbSNP:397516803
401 401 a, g dbSNP:121918466
402 402 c, g dbSNP:748952554
409 409 a, g dbSNP:397507515
411 411 a, g dbSNP:753788277
420 420 c, t dbSNP:61736914
454 454 c, g dbSNP:397507516
460 460 a, t dbSNP:387907158
466 466 c, g dbSNP:747470140
475 475 c, t dbSNP:747300372
480 480 a, t dbSNP:397516804
482 482 a, c dbSNP:397507517
493 493 a, g dbSNP:397507518
494 494 a, c dbSNP:397507519
518 518 -, ct dbSNP:398122859
534 534 a, g, t dbSNP:755619262
541 541 c, t dbSNP:146497890
546 546 c, t dbSNP:757004128
555 555 a, g dbSNP:542711611
557 557 a, g dbSNP:397516805
574 574 -, gtacg dbSNP:398122857
577 577 c, t dbSNP:267606989
582 582 c, g, t dbSNP:397507520
591 591 c, t dbSNP:199498784
597 597 c, t dbSNP:758194931
616 616 c, g dbSNP:768927453
617 617 c, t dbSNP:202026962
620 620 a, g dbSNP:397507521
623 623 aagaacacaggggagagca, ctggtg dbSNP:398122858
626 626 c, g dbSNP:376027245
632 632 a, g dbSNP:200712424
642 642 c, g dbSNP:769848611
651 651 c, t dbSNP:397507522
652 652 a, g dbSNP:730880992
660 660 a, t dbSNP:771233518
682 682 c, t dbSNP:545138829
683 683 a, g, t dbSNP:369155025
684 684 c, g dbSNP:767425313
693 693 a, g dbSNP:775493749
694 694 c, g dbSNP:760660964
702 702 c, t dbSNP:141015445
705 705 c, t dbSNP:753269427
721 721 c, t dbSNP:143433437
722 722 a, g dbSNP:764663951
723 723 g, t dbSNP:200920312
730 730 g, t dbSNP:79068130
737 737 a, c, g dbSNP:370763866
750 750 a, c dbSNP:753107691
756 756 g, t dbSNP:76982592
759 759 a, g dbSNP:778211349
763 763 a, t dbSNP:727503381
781 781 c, t dbSNP:78376169
786 786 c, t dbSNP:757304894
795 795 a, g dbSNP:778919108
797 797 a, t dbSNP:745331641
808 808 a, g dbSNP:773918720
813 813 a, g dbSNP:745489506
814 814 c, t dbSNP:771672596
818 818 a, g dbSNP:397507523
819 819 a, g dbSNP:775232682
821 821 -, aca dbSNP:397507524
825 825 g, t dbSNP:397516809
830 830 a, g dbSNP:773417679
832 832 c, t dbSNP:397507525
833 833 a, t dbSNP:765642157
836 836 a, g, t dbSNP:397507526
839 839 a, g dbSNP:763617831
844 844 a, c dbSNP:766531368
845 845 a, g dbSNP:376607329
852 852 g, t dbSNP:755104848
853 853 a, g, t dbSNP:397507527
865 865 a, g dbSNP:752966396
875 875 a, c dbSNP:397507528
878 878 a, g dbSNP:777603059
883 883 a, c dbSNP:749220083
885 885 a, g dbSNP:757228212
887 887 a, c, g dbSNP:121918456
895 895 a, g dbSNP:397507529
897 897 c, g dbSNP:397507530
898 898 a, c dbSNP:778374689
903 903 c, t dbSNP:571488248
904 904 c, g, t dbSNP:397507531
905 905 a, c, g, t dbSNP:121918463
906 906 g, t dbSNP:397516810
909 909 a, t dbSNP:397516811
930 930 c, g, t dbSNP:117730996
931 931 a, g dbSNP:376007642
932 932 a, g dbSNP:746607246
944 944 a, g dbSNP:572274623
948 948 a, g dbSNP:781010979
964 964 a, g dbSNP:730880995
972 972 a, g dbSNP:202019810
973 973 a, g dbSNP:28933386
974 974 a, c, g dbSNP:121918455
976 976 a, g dbSNP:201787206
982 982 a, g dbSNP:774939392
983 983 c, t dbSNP:201226824
990 990 a, g dbSNP:751028422
998 998 c, t dbSNP:547041954
1002 1002 a, g dbSNP:576405446
1004 1004 a, g dbSNP:747815170
1008 1008 c, t dbSNP:771407775
1018 1018 c, t dbSNP:779400765
1020 1020 a, c dbSNP:746329572
1022 1022 a, g dbSNP:772684421
1034 1034 c, t dbSNP:369430257
1036 1036 a, g dbSNP:760769867
1041 1041 a, c dbSNP:369739920
1047 1047 c, t dbSNP:397507533
1048 1048 a, t dbSNP:730880993
1062 1062 a, c, g dbSNP:371951288
1074 1074 c, t dbSNP:762516252
1079 1079 a, g dbSNP:535800148
1092 1092 a, g dbSNP:766297596
1099 1099 g, t dbSNP:146571700
1103 1103 a, g dbSNP:397507534
1104 1104 a, g dbSNP:190776554
1105 1105 c, g dbSNP:767192602
1108 1108 a, c dbSNP:752392909
1120 1120 a, g dbSNP:755871216
1122 1122 a, g dbSNP:779125362
1153 1153 a, g dbSNP:758737605
1171 1171 c, g dbSNP:397507535
1172 1172 a, g dbSNP:780328721
1175 1175 a, g dbSNP:41299183
1182 1182 a, c dbSNP:370059077
1194 1194 c, t dbSNP:781677115
1201 1201 c, t dbSNP:748162361
1204 1204 a, g dbSNP:769798916
1212 1212 c, t dbSNP:727505180
1213 1213 a, g dbSNP:749523268
1224 1224 c, t dbSNP:770730416
1225 1225 a, g dbSNP:774356443
1227 1227 c, t dbSNP:759533871
1241 1241 c, t dbSNP:767503386
1242 1242 a, g dbSNP:775571445
1268 1268 c, t dbSNP:760221298
1272 1272 a, g dbSNP:532529560
1276 1276 c, g, t dbSNP:779291780
1278 1278 c, t dbSNP:772022775
1279 1279 c, g dbSNP:377257792
1281 1281 a, g dbSNP:727504397
1289 1289 c, g dbSNP:201247699
1295 1295 a, c, t dbSNP:121918467
1301 1301 a, g dbSNP:761510407
1305 1305 c, g, t dbSNP:552394167
1329 1329 c, g dbSNP:759848374
1335 1335 a, g dbSNP:767920323
1340 1340 a, c dbSNP:727505389
1344 1344 c, t dbSNP:753173299
1345 1345 a, g dbSNP:397507536
1348 1348 c, t dbSNP:756647576
1359 1359 g, t dbSNP:150524715
1365 1365 c, t dbSNP:777895575
1371 1371 a, g dbSNP:753803665
1374 1374 c, t dbSNP:757362412
1378 1378 -, c dbSNP:398122860
1390 1390 c, t dbSNP:779236638
1408 1408 a, g dbSNP:746112827
1425 1425 a, g dbSNP:771967829
1429 1429 a, g, t dbSNP:397516796
1437 1437 a, c dbSNP:727504393
1444 1444 a, g, t dbSNP:121918468
1445 1445 c, g dbSNP:397509344
1454 1454 c, g dbSNP:121918469
1465 1465 a, c dbSNP:397507537
1466 1466 c, t dbSNP:121918457
1467 1467 c, g dbSNP:587781130
1471 1471 a, g dbSNP:779978269
1488 1488 c, t dbSNP:746719818
1494 1494 c, t dbSNP:139196273
1502 1502 a, g dbSNP:754837922
1503 1503 a, g dbSNP:780946087
1512 1512 g, t dbSNP:143238917
1516 1516 g, t dbSNP:397507538
1521 1521 c, t dbSNP:751834261
1523 1523 a, g dbSNP:730880994
1530 1530 c, t dbSNP:539373294
1531 1531 a, g dbSNP:781083623
1534 1534 a, c, g, t dbSNP:397507539
1535 1535 a, c, t dbSNP:397507540
1546 1546 c, g dbSNP:756104635
1555 1555 c, t dbSNP:397507541
1556 1556 g, t dbSNP:397507542
1565 1565 a, g dbSNP:397507543
1567 1567 a, g, t dbSNP:121918458
1568 1568 c, t dbSNP:397507544
1570 1570 a, c, g dbSNP:397507545
1571 1571 a, c, g, t dbSNP:397507546
1573 1573 a, g dbSNP:397507547
1579 1579 c, t dbSNP:387907157
1580 1580 ag, cc dbSNP:397509345
1580 1580 a, c dbSNP:397507548
1584 1584 a, g dbSNP:374285143
1591 1591 a, c, g dbSNP:397507549
1592 1592 a, c, g dbSNP:121918470
1593 1593 c, g dbSNP:397507550
1596 1596 c, t dbSNP:770457959
1609 1609 a, g dbSNP:773825880
1614 1614 a, g dbSNP:727504377
1638 1638 a, g dbSNP:143801479
1641 1641 c, g dbSNP:777116808
1642 1642 c, t dbSNP:191525506
1643 1643 a, g dbSNP:770363146
1657 1657 a, g dbSNP:587778634
1658 1658 a, g dbSNP:397507551
1671 1671 a, g dbSNP:763597585
1683 1683 c, t dbSNP:587781132
1684 1684 a, g dbSNP:186919241
1689 1689 c, t dbSNP:548648466
1706 1706 c, g dbSNP:759551230
1712 1712 c, t dbSNP:767712281
1713 1713 a, g dbSNP:374896287
1721 1721 c, t dbSNP:148176616
1733 1733 a, g dbSNP:763926088
1734 1734 c, g dbSNP:753741561
1741 1741 c, t dbSNP:397516797
1743 1743 c, t dbSNP:778270727
1745 1745 c, t dbSNP:141140214
1746 1746 a, g dbSNP:397516798
1753 1753 a, t dbSNP:779810329
1759 1759 a, g, t dbSNP:746712068
1760 1760 c, t dbSNP:150730493
1767 1767 c, t dbSNP:749748127
1787 1787 a, g dbSNP:397516799
1789 1789 a, c dbSNP:754106920
1790 1790 a, g dbSNP:781006724
1792 1792 a, g dbSNP:567223058
1796 1796 g, t dbSNP:757593532
1797 1797 a, g dbSNP:779428225
1798 1798 a, g dbSNP:746410911
1803 1803 c, t dbSNP:139188627
1809 1809 c, t dbSNP:397516800
1818 1818 a, g dbSNP:747217473
1829 1829 a, g dbSNP:768805690
1847 1847 -, a dbSNP:773953867
1858 1858 a, g dbSNP:201957261
1861 1861 c, g dbSNP:761625067
1895 1895 c, t dbSNP:730880328
1909 1909 c, g dbSNP:763895470
1914 1914 a, g dbSNP:534038243
1919 1919 c, t dbSNP:753963471
1920 1920 a, g dbSNP:150401860
1928 1928 c, g dbSNP:765423442
1944 1944 a, c dbSNP:567646243
1972 1972 a, g dbSNP:56328752
1973 1973 c, t dbSNP:538274355
1996 1996 a, g dbSNP:750501282
2020 2020 g, t dbSNP:11831567
2031 2031 c, g dbSNP:548110853
2043 2043 c, t dbSNP:577940989
2061 2061 -, c dbSNP:761290107
2123 2123 a, g dbSNP:538914783
2144 2144 c, t dbSNP:190067634
2149 2149 c, t dbSNP:181914703
2150 2150 a, g dbSNP:187361583
2170 2170 a, g dbSNP:192080780
2174 2174 c, t dbSNP:576039073
2226 2226 a, t dbSNP:7138192
2293 2293 c, t dbSNP:372026055
2336 2336 c, g dbSNP:3241
2344 2344 a, g, t dbSNP:3240
2405 2405 -, tg dbSNP:552074590
2502 2502 c, t dbSNP:73209639
2509 2509 c, t dbSNP:59642166
2515 2515 a, g dbSNP:112287134
2522 2522 a, g dbSNP:781589777
2532 2532 c, t dbSNP:748512308
2533 2533 a, g dbSNP:550138781
2558 2558 a, g dbSNP:532463412
2565 2565 c, t dbSNP:770605810
2566 2566 a, g dbSNP:547673624
2619 2619 c, t dbSNP:768178137
2620 2620 a, g dbSNP:181946923
2644 2644 a, g dbSNP:745319452
2646 2646 c, t dbSNP:138246203
2647 2647 a, g dbSNP:753900307
2662 2662 c, t dbSNP:775361295
2683 2683 a, g dbSNP:142648640
2718 2718 a, g dbSNP:760633338
2732 2732 c, t dbSNP:567777121
2736 2736 -, g dbSNP:35137864
2771 2771 a, c dbSNP:763974602
2787 2787 c, t dbSNP:537926588
2816 2816 c, t dbSNP:547853005
2845 2845 c, t dbSNP:776462452
2848 2848 c, t dbSNP:549782052
2850 2850 -, g dbSNP:778240486
2850 2850 c, t dbSNP:571269321
2851 2851 -, g dbSNP:146940557
2860 2860 c, g dbSNP:538946251
2867 2867 c, t dbSNP:554094011
2909 2909 a, g dbSNP:184934232
2930 2930 a, g dbSNP:189739744
2941 2941 c, g dbSNP:554845080
2980 2980 g, t dbSNP:146895091
3000 3000 -, tgatgatga dbSNP:199618935
3000 3000 -, tga dbSNP:148422684
3002 3002 -, tga dbSNP:752248234
3029 3029 a, t dbSNP:543116936
3044 3044 -, atg dbSNP:80269561
3063 3063 a, g dbSNP:558595665
3172 3172 c, g dbSNP:761568292
3219 3219 c, g dbSNP:139266170
3248 3248 a, g dbSNP:377746315
3258 3258 a, c dbSNP:765490519
3368 3368 a, g dbSNP:541018423
3381 3381 c, g, t dbSNP:371375321
3455 3455 a, g dbSNP:750612632
3623 3623 c, t dbSNP:182366345
3650 3650 c, t dbSNP:188162577
3651 3651 a, g dbSNP:766598691
3677 3677 c, t dbSNP:563302019
3721 3721 a, g dbSNP:751729224
3724 3724 g, t dbSNP:191798571
3732 3732 c, t dbSNP:746823887
3779 3779 g, t dbSNP:183574699
3870 3870 a, c, t dbSNP:755522105
3907 3907 a, t dbSNP:571408138
3923 3923 a, g dbSNP:144513512
3941 3941 g, t dbSNP:547373116
3974 3974 a, g dbSNP:188963648
3995 3995 g, t dbSNP:756441720
4010 4010 c, t dbSNP:192434262
4069 4069 c, g dbSNP:555160753
4070 4070 c, t dbSNP:183450083
4089 4089 -, cttga dbSNP:759302517
4144 4144 c, t dbSNP:537146777
4226 4226 a, g dbSNP:770759391
4233 4233 a, c dbSNP:781166352
4241 4241 a, g dbSNP:745822311
4245 4245 c, t dbSNP:769653135
4272 4272 c, t dbSNP:745546287
4278 4278 a, g dbSNP:553718791
4287 4287 a, g dbSNP:775013499
4290 4290 c, t dbSNP:11556500
4293 4293 -, g dbSNP:35369108
4297 4297 a, g dbSNP:186635899
4299 4299 a, t dbSNP:78622120
4347 4347 a, g dbSNP:17849095
4351 4351 c, t dbSNP:577110001
4361 4361 c, t dbSNP:771526838
4382 4382 a, g dbSNP:541055190
4398 4398 a, g dbSNP:373724024
4454 4454 a, g dbSNP:148005691
4474 4474 a, g dbSNP:141655134
4481 4481 a, g dbSNP:371690901
4524 4524 c, t dbSNP:541715735
4534 4534 c, t dbSNP:539696412
4567 4567 c, t dbSNP:145941353
4575 4575 c, t dbSNP:746568122
4576 4576 a, g dbSNP:768622106
4696 4696 c, g dbSNP:76233443
4733 4733 -, a dbSNP:35572550
4758 4758 g, t dbSNP:191451558
4772 4772 a, t dbSNP:190612693
4773 4773 a, t dbSNP:565075386
4840 4840 c, t dbSNP:55853479
4851 4851 a, g dbSNP:141870860
4853 4853 c, g dbSNP:547411598
4888 4888 c, t dbSNP:41307084
5014 5014 a, t dbSNP:530432349
5038 5038 a, g dbSNP:548553622
5076 5076 g, t dbSNP:769489372
5088 5088 c, t dbSNP:773518583
5089 5089 a, g dbSNP:763237386
5113 5113 a, g dbSNP:570319517
5129 5129 c, t dbSNP:542362692
5154 5154 c, t dbSNP:766757908
5169 5169 -, t dbSNP:57848522
5179 5179 c, g dbSNP:139164037
5226 5226 a, g dbSNP:374962107
5237 5237 -, t dbSNP:34105680
5276 5276 c, t dbSNP:751678120
5283 5283 a, c dbSNP:774023322
5342 5342 c, t dbSNP:570581746
5347 5347 a, g dbSNP:149928405
5383 5383 a, t dbSNP:759758035
5385 5385 c, t dbSNP:184174716
5477 5477 c, t dbSNP:552940791
5531 5531 c, t dbSNP:189762784
5639 5639 c, t dbSNP:535425660
5640 5640 a, g dbSNP:557017130
5664 5664 a, g dbSNP:762150907
5675 5675 a, g dbSNP:1985752
5679 5679 g, t dbSNP:575177579
5700 5700 a, t dbSNP:768004889
5709 5709 -, gt dbSNP:556122395
5721 5721 a, g dbSNP:765068888
5743 5743 c, t dbSNP:372268360
5746 5746 a, c, t dbSNP:182289916
5816 5816 a, g dbSNP:572565511
5865 5865 a, g dbSNP:750757268

Target ORF information:

RefSeq Version XM_006719527
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006719527

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAG AAATGGAGCT GTCACCCACA TCAAGATTCA GAACACTGGT
GATTACTATG ACCTGTATGG AGGGGAGAAA TTTGCCACTT TGGCTGAGTT GGTCCAGTAT
TACATGGAAC ATCACGGGCA ATTAAAAGAG AAGAATGGAG ATGTCATTGA GCTTAAATAT
CCTCTGAACT GTGCAGATCC TACCTCTGAA AGGTGGTTTC ATGGACATCT CTCTGGGAAA
GAAGCAGAGA AATTATTAAC TGAAAAAGGA AAACATGGTA GTTTTCTTGT ACGAGAGAGC
CAGAGCCACC CTGGAGATTT TGTTCTTTCT GTGCGCACTG GTGATGACAA AGGGGAGAGC
AATGACGGCA AGTCTAAAGT GACCCATGTT ATGATTCGCT GTCAGGAACT GAAATACGAC
GTTGGTGGAG GAGAACGGTT TGATTCTTTG ACAGATCTTG TGGAACATTA TAAGAAGAAT
CCTATGGTGG AAACATTGGG TACAGTACTA CAACTCAAGC AGACACTACA ACAACAGGAG
TGCAAACTTC TCTACAGCCG AAAAGAGGGT CAAAGGCAAG AAAACAAAAA CAAAAATAGA
TATAAAAACA TCCTGCCCTT TGATCATACC AGGGTTGTCC TACACGATGG TGATCCCAAT
GAGCCTGTTT CAGATTACAT CAATGCAAAT ATCATCATGC CTGAATTTGA AACCAAGTGC
AACAATTCAA AGCCCAAAAA GAGTTACATT GCCACACAAG GCTGCCTGCA AAACACGGTG
AATGACTTTT GGCGGATGGT GTTCCAAGAA AACTCCCGAG TGATTGTCAT GACAACGAAA
GAAGTGGAGA GAGGAAAGAG TAAATGTGTC AAATACTGGC CTGATGAGTA TGCTCTAAAA
GAATATGGCG TCATGCGTGT TAGGAACGTC AAAGAAAGCG CCGCTCATGA CTATACGCTA
AGAGAACTTA AACTTTCAAA GGTTGGACAA GCTCTACTCC AGGGGAATAC GGAGAGAACG
GTCTGGCAAT ACCACTTTCG GACCTGGCCG GACCACGGCG TGCCCAGCGA CCCTGGGGGC
GTGCTGGACT TCCTGGAGGA GGTGCACCAT AAGCAGGAGA GCATCATGGA TGCAGGGCCG
GTCGTGGTGC ACTGCAGTGC TGGAATTGGC CGGACAGGGA CGTTCATTGT GATTGATATT
CTTATTGACA TCATCAGAGA GAAAGGTGTT GACTGCGATA TTGACGTTCC CAAAACCATC
CAGATGGTGC GGTCTCAGAG GTCAGGGATG GTCCAGACAG AAGCACAGTA CCGATTTATC
TATATGGCGG TCCAGCATTA TATTGAAACA CTACAGCGCA GGATTGAAGA AGAGCAGAAA
AGCAAGAGGA AAGGGCACGA ATATACAAAT ATTAAGTATT CTCTAGCGGA CCAGACGAGT
GGAGATCAGA GCCCTCTCCC GCCTTGTACT CCAACGCCAC CCTGTGCAGA AATGAGAGAA
GACAGTGCTA GAGTCTATGA AAACGTGGGC CTGATGCAAC AGCAGAAAAG TTTCAGATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25096
Accession Version NM_002834.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1782bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product tyrosine-protein phosphatase non-receptor type 11 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF515187.1, AK289854.1, CN258646.1, BX537632.1 and AC004216.1. This sequence is a reference standard in the RefSeqGene project. On or before Jul 31, 2003 this sequence version replaced gi:14249675, gi:18375641. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D13540.1, L08807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGACATCGC GGAGATGGTT TCACCCAAAT ATCACTGGTG TGGAGGCAGA AAACCTACTG 
TTGACAAGAG GAGTTGATGG CAGTTTTTTG GCAAGGCCTA GTAAAAGTAA CCCTGGAGAC
TTCACACTTT CCGTTAGAAG AAATGGAGCT GTCACCCACA TCAAGATTCA GAACACTGGT
GATTACTATG ACCTGTATGG AGGGGAGAAA TTTGCCACTT TGGCTGAGTT GGTCCAGTAT
TACATGGAAC ATCACGGGCA ATTAAAAGAG AAGAATGGAG ATGTCATTGA GCTTAAATAT
CCTCTGAACT GTGCAGATCC TACCTCTGAA AGGTGGTTTC ATGGACATCT CTCTGGGAAA
GAAGCAGAGA AATTATTAAC TGAAAAAGGA AAACATGGTA GTTTTCTTGT ACGAGAGAGC
CAGAGCCACC CTGGAGATTT TGTTCTTTCT GTGCGCACTG GTGATGACAA AGGGGAGAGC
AATGACGGCA AGTCTAAAGT GACCCATGTT ATGATTCGCT GTCAGGAACT GAAATACGAC
GTTGGTGGAG GAGAACGGTT TGATTCTTTG ACAGATCTTG TGGAACATTA TAAGAAGAAT
CCTATGGTGG AAACATTGGG TACAGTACTA CAACTCAAGC AGCCCCTTAA CACGACTCGT
ATAAATGCTG CTGAAATAGA AAGCAGAGTT CGAGAACTAA GCAAATTAGC TGAGACCACA
GATAAAGTCA AACAAGGCTT TTGGGAAGAA TTTGAGACAC TACAACAACA GGAGTGCAAA
CTTCTCTACA GCCGAAAAGA GGGTCAAAGG CAAGAAAACA AAAACAAAAA TAGATATAAA
AACATCCTGC CCTTTGATCA TACCAGGGTT GTCCTACACG ATGGTGATCC CAATGAGCCT
GTTTCAGATT ACATCAATGC AAATATCATC ATGCCTGAAT TTGAAACCAA GTGCAACAAT
TCAAAGCCCA AAAAGAGTTA CATTGCCACA CAAGGCTGCC TGCAAAACAC GGTGAATGAC
TTTTGGCGGA TGGTGTTCCA AGAAAACTCC CGAGTGATTG TCATGACAAC GAAAGAAGTG
GAGAGAGGAA AGAGTAAATG TGTCAAATAC TGGCCTGATG AGTATGCTCT AAAAGAATAT
GGCGTCATGC GTGTTAGGAA CGTCAAAGAA AGCGCCGCTC ATGACTATAC GCTAAGAGAA
CTTAAACTTT CAAAGGTTGG ACAAGGGAAT ACGGAGAGAA CGGTCTGGCA ATACCACTTT
CGGACCTGGC CGGACCACGG CGTGCCCAGC GACCCTGGGG GCGTGCTGGA CTTCCTGGAG
GAGGTGCACC ATAAGCAGGA GAGCATCATG GATGCAGGGC CGGTCGTGGT GCACTGCAGT
GCTGGAATTG GCCGGACAGG GACGTTCATT GTGATTGATA TTCTTATTGA CATCATCAGA
GAGAAAGGTG TTGACTGCGA TATTGACGTT CCCAAAACCA TCCAGATGGT GCGGTCTCAG
AGGTCAGGGA TGGTCCAGAC AGAAGCACAG TACCGATTTA TCTATATGGC GGTCCAGCAT
TATATTGAAA CACTACAGCG CAGGATTGAA GAAGAGCAGA AAAGCAAGAG GAAAGGGCAC
GAATATACAA ATATTAAGTA TTCTCTAGCG GACCAGACGA GTGGAGATCA GAGCCCTCTC
CCGCCTTGTA CTCCAACGCC ACCCTGTGCA GAAATGAGAG AAGACAGTGC TAGAGTCTAT
GAAAACGTGG GCCTGATGCA ACAGCAGAAA AGTTTCAGAT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002825.3
CDS381..2162
Misc Feature(1)336..338(+)
Misc Feature(2)384..386(+)
Misc Feature(3)393..689(+)
Misc Feature(4)417..545(+)
Misc Feature(5)534..659(+)
Misc Feature(6)564..566(+)
Misc Feature(7)564..566(+)
Misc Feature(8)567..569(+)
Misc Feature(9)567..569(+)
Misc Feature(10)711..1034(+)
Misc Feature(11)795..821(+)
Misc Feature(12)888..971(+)
Misc Feature(13)1116..1940(+)
Misc Feature(14)1206..1937(+)
Misc Feature(15)1653..1778(+)
Misc Feature(16)1755..1775(+)
Misc Feature(17)2004..2006(+)
Misc Feature(18)2004..2006(+)
Misc Feature(19)2052..2054(+)
Misc Feature(20)2106..2108(+)
Misc Feature(21)2106..2108(+)
Misc Feature(22)2106..2108(+)
Misc Feature(23)2118..2120(+)
Misc Feature(24)2118..2120(+)
Misc Feature(25)2151..2153(+)
Exon (1)1..394
Gene:PTPN11
Gene Synonym:
Exon (2)395..517
Gene:PTPN11
Gene Synonym:
Exon (3)518..712
Gene:PTPN11
Gene Synonym:
Exon (4)713..905
Gene:PTPN11
Gene Synonym:
Exon (5)906..1022
Gene:PTPN11
Gene Synonym:
Exon (6)1023..1136
Gene:PTPN11
Gene Synonym:
Exon (7)1137..1233
Gene:PTPN11
Gene Synonym:
Exon (8)1234..1313
Gene:PTPN11
Gene Synonym:
Exon (9)1314..1472
Gene:PTPN11
Gene Synonym:
Exon (10)1473..1604
Gene:PTPN11
Gene Synonym:
Exon (11)1605..1759
Gene:PTPN11
Gene Synonym:
Exon (12)1760..1827
Gene:PTPN11
Gene Synonym:
Exon (13)1828..1979
Gene:PTPN11
Gene Synonym:
Exon (14)1980..2092
Gene:PTPN11
Gene Synonym:
Exon (15)2093..2194
Gene:PTPN11
Gene Synonym:
Exon (16)2195..6283
Gene:PTPN11
Gene Synonym:
Translation
Position Chain Variation Link
45 45 c, g dbSNP:538616585
58 58 g, t dbSNP:61941345
64 64 c, g, t dbSNP:373537430
85 85 c, t dbSNP:375766559
94 94 c, g dbSNP:377496292
95 95 c, g dbSNP:542603894
97 97 c, t dbSNP:554850776
108 108 a, g dbSNP:58805176
132 132 a, g dbSNP:543228277
158 158 a, g dbSNP:760804966
194 194 c, g dbSNP:562614931
201 201 a, g dbSNP:149766959
202 202 g, t dbSNP:545369072
209 209 g, t dbSNP:532311943
214 214 a, g dbSNP:560323658
246 246 a, g dbSNP:527982856
260 260 g, t dbSNP:554487214
279 279 c, t dbSNP:567977545
291 291 a, g dbSNP:531915358
304 304 a, g dbSNP:766412799
321 321 g, t dbSNP:550428179
336 336 g, t dbSNP:587781131
354 354 a, g dbSNP:375495669
368 368 a, g dbSNP:760374212
385 385 c, t dbSNP:267606990
386 386 a, g dbSNP:768238710
393 393 a, g dbSNP:587781133
398 398 g, t dbSNP:79203122
405 405 c, g dbSNP:566068139
406 406 a, c dbSNP:536503257
408 408 a, g dbSNP:368633510
409 409 a, g dbSNP:200613531
416 416 c, t dbSNP:760086740
428 428 a, g dbSNP:372736227
432 432 a, g dbSNP:776089364
433 433 a, g dbSNP:587778635
436 436 g, t dbSNP:397507500
437 437 a, g dbSNP:764238610
438 438 c, g dbSNP:753951666
444 444 a, g dbSNP:757537175
446 446 a, g dbSNP:397516808
456 456 a, g dbSNP:750261927
494 494 g, t dbSNP:758209360
497 497 a, c dbSNP:779813529
499 499 a, g dbSNP:397516795
504 504 a, g dbSNP:397507501
512 512 a, c, t dbSNP:397507502
523 523 a, g dbSNP:765495843
528 528 a, g dbSNP:587778636
535 535 c, t dbSNP:397507503
536 536 c, t dbSNP:147388185
539 539 c, t dbSNP:766205831
546 546 a, g dbSNP:397507504
552 552 a, c, g, t dbSNP:397507505
553 553 a, g dbSNP:751437780
554 554 a, c, g dbSNP:397507506
558 558 -, ggt dbSNP:121918471
558 558 a, g, t dbSNP:397507507
559 559 gtga, t dbSNP:397507508
559 559 -, gtg dbSNP:80338836
559 559 c, g, t dbSNP:397507509
561 561 a, c, g dbSNP:397507510
562 562 a, c, g, t dbSNP:121918461
564 564 a, g, t dbSNP:121918460
568 568 a, g dbSNP:121918459
585 585 c, g dbSNP:397507511
586 586 a, t dbSNP:727503380
589 589 a, g dbSNP:397516801
591 591 c, g, t dbSNP:397507512
592 592 g, t dbSNP:755709231
594 594 a, c, g, t dbSNP:121918453
595 595 c, g, t dbSNP:121918454
596 596 c, t dbSNP:777529056
597 597 ac, ct dbSNP:397516802
597 597 a, c dbSNP:397507513
598 598 c, t dbSNP:121918462
606 606 a, c, g dbSNP:121918464
607 607 a, c, g, t dbSNP:121918465
608 608 c, g, t dbSNP:397507514
615 615 a, c dbSNP:397516803
616 616 a, g dbSNP:121918466
617 617 c, g dbSNP:748952554
624 624 a, g dbSNP:397507515
626 626 a, g dbSNP:753788277
635 635 c, t dbSNP:61736914
669 669 c, g dbSNP:397507516
675 675 a, t dbSNP:387907158
681 681 c, g dbSNP:747470140
690 690 c, t dbSNP:747300372
695 695 a, t dbSNP:397516804
697 697 a, c dbSNP:397507517
708 708 a, g dbSNP:397507518
709 709 a, c dbSNP:397507519
733 733 -, ct dbSNP:398122859
749 749 a, g, t dbSNP:755619262
756 756 c, t dbSNP:146497890
761 761 c, t dbSNP:757004128
770 770 a, g dbSNP:542711611
772 772 a, g dbSNP:397516805
789 789 -, gtacg dbSNP:398122857
792 792 c, t dbSNP:267606989
797 797 c, g, t dbSNP:397507520
806 806 c, t dbSNP:199498784
812 812 c, t dbSNP:758194931
831 831 c, g dbSNP:768927453
832 832 c, t dbSNP:202026962
835 835 a, g dbSNP:397507521
838 838 aagaacacaggggagagca, ctggtg dbSNP:398122858
841 841 c, g dbSNP:376027245
847 847 a, g dbSNP:200712424
857 857 c, g dbSNP:769848611
866 866 c, t dbSNP:397507522
867 867 a, g dbSNP:730880992
875 875 a, t dbSNP:771233518
897 897 c, t dbSNP:545138829
898 898 a, g, t dbSNP:369155025
899 899 c, g dbSNP:767425313
908 908 a, g dbSNP:775493749
909 909 c, g dbSNP:760660964
917 917 c, t dbSNP:141015445
920 920 c, t dbSNP:753269427
936 936 c, t dbSNP:143433437
937 937 a, g dbSNP:764663951
938 938 g, t dbSNP:200920312
945 945 g, t dbSNP:79068130
952 952 a, c, g dbSNP:370763866
965 965 a, c dbSNP:753107691
971 971 g, t dbSNP:76982592
974 974 a, g dbSNP:778211349
978 978 a, t dbSNP:727503381
996 996 c, t dbSNP:78376169
1001 1001 c, t dbSNP:757304894
1010 1010 a, g dbSNP:778919108
1012 1012 a, t dbSNP:745331641
1031 1031 c, g dbSNP:747243342
1032 1032 a, g dbSNP:768555552
1034 1034 a, g dbSNP:568340391
1039 1039 a, g dbSNP:780911423
1041 1041 -, a dbSNP:397516807
1041 1041 a, g, t dbSNP:397516806
1063 1063 g, t dbSNP:748085966
1081 1081 a, g dbSNP:730881220
1097 1097 c, g dbSNP:138215269
1137 1137 a, g dbSNP:773918720
1142 1142 a, g dbSNP:745489506
1143 1143 c, t dbSNP:771672596
1147 1147 a, g dbSNP:397507523
1148 1148 a, g dbSNP:775232682
1150 1150 -, aca dbSNP:397507524
1154 1154 g, t dbSNP:397516809
1159 1159 a, g dbSNP:773417679
1161 1161 c, t dbSNP:397507525
1162 1162 a, t dbSNP:765642157
1165 1165 a, g, t dbSNP:397507526
1168 1168 a, g dbSNP:763617831
1173 1173 a, c dbSNP:766531368
1174 1174 a, g dbSNP:376607329
1181 1181 g, t dbSNP:755104848
1182 1182 a, g, t dbSNP:397507527
1194 1194 a, g dbSNP:752966396
1204 1204 a, c dbSNP:397507528
1207 1207 a, g dbSNP:777603059
1212 1212 a, c dbSNP:749220083
1214 1214 a, g dbSNP:757228212
1216 1216 a, c, g dbSNP:121918456
1224 1224 a, g dbSNP:397507529
1226 1226 c, g dbSNP:397507530
1227 1227 a, c dbSNP:778374689
1232 1232 c, t dbSNP:571488248
1233 1233 c, g, t dbSNP:397507531
1234 1234 a, c, g, t dbSNP:121918463
1235 1235 g, t dbSNP:397516810
1238 1238 a, t dbSNP:397516811
1259 1259 c, g, t dbSNP:117730996
1260 1260 a, g dbSNP:376007642
1261 1261 a, g dbSNP:746607246
1273 1273 a, g dbSNP:572274623
1277 1277 a, g dbSNP:781010979
1293 1293 a, g dbSNP:730880995
1301 1301 a, g dbSNP:202019810
1302 1302 a, g dbSNP:28933386
1303 1303 a, c, g dbSNP:121918455
1305 1305 a, g dbSNP:201787206
1311 1311 a, g dbSNP:774939392
1312 1312 c, t dbSNP:201226824
1319 1319 a, g dbSNP:751028422
1327 1327 c, t dbSNP:547041954
1331 1331 a, g dbSNP:576405446
1333 1333 a, g dbSNP:747815170
1337 1337 c, t dbSNP:771407775
1347 1347 c, t dbSNP:779400765
1349 1349 a, c dbSNP:746329572
1351 1351 a, g dbSNP:772684421
1363 1363 c, t dbSNP:369430257
1365 1365 a, g dbSNP:760769867
1370 1370 a, c dbSNP:369739920
1376 1376 c, t dbSNP:397507533
1377 1377 a, t dbSNP:730880993
1391 1391 a, c, g dbSNP:371951288
1403 1403 c, t dbSNP:762516252
1408 1408 a, g dbSNP:535800148
1421 1421 a, g dbSNP:766297596
1428 1428 g, t dbSNP:146571700
1432 1432 a, g dbSNP:397507534
1433 1433 a, g dbSNP:190776554
1434 1434 c, g dbSNP:767192602
1437 1437 a, c dbSNP:752392909
1449 1449 a, g dbSNP:755871216
1451 1451 a, g dbSNP:779125362
1482 1482 a, g dbSNP:758737605
1500 1500 c, g dbSNP:397507535
1501 1501 a, g dbSNP:780328721
1504 1504 a, g dbSNP:41299183
1511 1511 a, c dbSNP:370059077
1523 1523 c, t dbSNP:781677115
1530 1530 c, t dbSNP:748162361
1533 1533 a, g dbSNP:769798916
1541 1541 c, t dbSNP:727505180
1542 1542 a, g dbSNP:749523268
1553 1553 c, t dbSNP:770730416
1554 1554 a, g dbSNP:774356443
1556 1556 c, t dbSNP:759533871
1570 1570 c, t dbSNP:767503386
1571 1571 a, g dbSNP:775571445
1597 1597 c, t dbSNP:760221298
1601 1601 a, g dbSNP:532529560
1606 1606 c, g dbSNP:201247699
1612 1612 a, c, t dbSNP:121918467
1618 1618 a, g dbSNP:761510407
1622 1622 c, g, t dbSNP:552394167
1646 1646 c, g dbSNP:759848374
1652 1652 a, g dbSNP:767920323
1657 1657 a, c dbSNP:727505389
1661 1661 c, t dbSNP:753173299
1662 1662 a, g dbSNP:397507536
1665 1665 c, t dbSNP:756647576
1676 1676 g, t dbSNP:150524715
1682 1682 c, t dbSNP:777895575
1688 1688 a, g dbSNP:753803665
1691 1691 c, t dbSNP:757362412
1695 1695 -, c dbSNP:398122860
1707 1707 c, t dbSNP:779236638
1725 1725 a, g dbSNP:746112827
1742 1742 a, g dbSNP:771967829
1746 1746 a, g, t dbSNP:397516796
1754 1754 a, c dbSNP:727504393
1761 1761 a, g, t dbSNP:121918468
1762 1762 c, g dbSNP:397509344
1771 1771 c, g dbSNP:121918469
1782 1782 a, c dbSNP:397507537
1783 1783 c, t dbSNP:121918457
1784 1784 c, g dbSNP:587781130
1788 1788 a, g dbSNP:779978269
1805 1805 c, t dbSNP:746719818
1811 1811 c, t dbSNP:139196273
1819 1819 a, g dbSNP:754837922
1820 1820 a, g dbSNP:780946087
1829 1829 g, t dbSNP:143238917
1833 1833 g, t dbSNP:397507538
1838 1838 c, t dbSNP:751834261
1840 1840 a, g dbSNP:730880994
1847 1847 c, t dbSNP:539373294
1848 1848 a, g dbSNP:781083623
1851 1851 a, c, g, t dbSNP:397507539
1852 1852 a, c, t dbSNP:397507540
1863 1863 c, g dbSNP:756104635
1872 1872 c, t dbSNP:397507541
1873 1873 g, t dbSNP:397507542
1882 1882 a, g dbSNP:397507543
1884 1884 a, g, t dbSNP:121918458
1885 1885 c, t dbSNP:397507544
1887 1887 a, c, g dbSNP:397507545
1888 1888 a, c, g, t dbSNP:397507546
1890 1890 a, g dbSNP:397507547
1896 1896 c, t dbSNP:387907157
1897 1897 ag, cc dbSNP:397509345
1897 1897 a, c dbSNP:397507548
1901 1901 a, g dbSNP:374285143
1908 1908 a, c, g dbSNP:397507549
1909 1909 a, c, g dbSNP:121918470
1910 1910 c, g dbSNP:397507550
1913 1913 c, t dbSNP:770457959
1926 1926 a, g dbSNP:773825880
1931 1931 a, g dbSNP:727504377
1955 1955 a, g dbSNP:143801479
1958 1958 c, g dbSNP:777116808
1959 1959 c, t dbSNP:191525506
1960 1960 a, g dbSNP:770363146
1974 1974 a, g dbSNP:587778634
1975 1975 a, g dbSNP:397507551
1988 1988 a, g dbSNP:763597585
2000 2000 c, t dbSNP:587781132
2001 2001 a, g dbSNP:186919241
2006 2006 c, t dbSNP:548648466
2023 2023 c, g dbSNP:759551230
2029 2029 c, t dbSNP:767712281
2030 2030 a, g dbSNP:374896287
2038 2038 c, t dbSNP:148176616
2050 2050 a, g dbSNP:763926088
2051 2051 c, g dbSNP:753741561
2058 2058 c, t dbSNP:397516797
2060 2060 c, t dbSNP:778270727
2062 2062 c, t dbSNP:141140214
2063 2063 a, g dbSNP:397516798
2070 2070 a, t dbSNP:779810329
2076 2076 a, g, t dbSNP:746712068
2077 2077 c, t dbSNP:150730493
2084 2084 c, t dbSNP:749748127
2104 2104 a, g dbSNP:397516799
2106 2106 a, c dbSNP:754106920
2107 2107 a, g dbSNP:781006724
2109 2109 a, g dbSNP:567223058
2113 2113 g, t dbSNP:757593532
2114 2114 a, g dbSNP:779428225
2115 2115 a, g dbSNP:746410911
2120 2120 c, t dbSNP:139188627
2126 2126 c, t dbSNP:397516800
2135 2135 a, g dbSNP:747217473
2146 2146 a, g dbSNP:768805690
2164 2164 -, a dbSNP:773953867
2175 2175 a, g dbSNP:201957261
2178 2178 c, g dbSNP:761625067
2212 2212 c, t dbSNP:730880328
2226 2226 c, g dbSNP:763895470
2231 2231 a, g dbSNP:534038243
2236 2236 c, t dbSNP:753963471
2237 2237 a, g dbSNP:150401860
2245 2245 c, g dbSNP:765423442
2261 2261 a, c dbSNP:567646243
2289 2289 a, g dbSNP:56328752
2290 2290 c, t dbSNP:538274355
2313 2313 a, g dbSNP:750501282
2337 2337 g, t dbSNP:11831567
2348 2348 c, g dbSNP:548110853
2360 2360 c, t dbSNP:577940989
2378 2378 -, c dbSNP:761290107
2440 2440 a, g dbSNP:538914783
2461 2461 c, t dbSNP:190067634
2466 2466 c, t dbSNP:181914703
2467 2467 a, g dbSNP:187361583
2487 2487 a, g dbSNP:192080780
2491 2491 c, t dbSNP:576039073
2543 2543 a, t dbSNP:7138192
2610 2610 c, t dbSNP:372026055
2653 2653 c, g dbSNP:3241
2661 2661 a, g, t dbSNP:3240
2722 2722 -, tg dbSNP:552074590
2819 2819 c, t dbSNP:73209639
2826 2826 c, t dbSNP:59642166
2832 2832 a, g dbSNP:112287134
2839 2839 a, g dbSNP:781589777
2849 2849 c, t dbSNP:748512308
2850 2850 a, g dbSNP:550138781
2875 2875 a, g dbSNP:532463412
2882 2882 c, t dbSNP:770605810
2883 2883 a, g dbSNP:547673624
2936 2936 c, t dbSNP:768178137
2937 2937 a, g dbSNP:181946923
2961 2961 a, g dbSNP:745319452
2963 2963 c, t dbSNP:138246203
2964 2964 a, g dbSNP:753900307
2979 2979 c, t dbSNP:775361295
3000 3000 a, g dbSNP:142648640
3035 3035 a, g dbSNP:760633338
3049 3049 c, t dbSNP:567777121
3053 3053 -, g dbSNP:35137864
3088 3088 a, c dbSNP:763974602
3104 3104 c, t dbSNP:537926588
3133 3133 c, t dbSNP:547853005
3162 3162 c, t dbSNP:776462452
3165 3165 c, t dbSNP:549782052
3167 3167 -, g dbSNP:778240486
3167 3167 c, t dbSNP:571269321
3168 3168 -, g dbSNP:146940557
3177 3177 c, g dbSNP:538946251
3184 3184 c, t dbSNP:554094011
3226 3226 a, g dbSNP:184934232
3247 3247 a, g dbSNP:189739744