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PTS cDNA ORF clone, Homo sapiens (human)

Gene Symbol PTS
Entrez Gene ID 5805
Full Name 6-pyruvoyltetrahydropterin synthase
Synonyms PTPS
General protein information
Preferred Names
6-pyruvoyl tetrahydrobiopterin synthase
Names
6-pyruvoyl tetrahydrobiopterin synthase
PTP synthase
NP_000308.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22.3

Summary The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

612719

Disorder Html: Hyperphenylalaninemia, BH4-deficient, A, 261640 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011542943 XP_011541245 6-pyruvoyl tetrahydrobiopterin synthase isoform X1
NM_000317 NP_000308 6-pyruvoyl tetrahydrobiopterin synthase



Homo sapiens (human) PTS NP_000308.1
Pan troglodytes (chimpanzee) PTS XP_001147929.1
Macaca mulatta (Rhesus monkey) PTS XP_001108264.1
Canis lupus familiaris (dog) PTS XP_854076.1
Bos taurus (cattle) PTS NP_001107009.1
Mus musculus (house mouse) Pts NP_035350.1
Rattus norvegicus (Norway rat) Pts NP_058916.1
Gallus gallus (chicken) PTS XP_004948194.1
Danio rerio (zebrafish) pts NP_001092237.1
Drosophila melanogaster (fruit fly) pr NP_724244.1
Caenorhabditis elegans ptps-1 NP_001040626.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100487259 XP_002937697.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PTS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60124 XM_011542943 PREDICTED: Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu19651
NM_000317 Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu60124
Clone ID Related Accession (Same CDS sequence) XM_011542943
Accession Version XM_011542943.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 399bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product 6-pyruvoyl tetrahydrobiopterin synthase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_033899.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
ATGTGTAAAG CACTGATAAA GTTTTTTTTT GTTGTTGTTG TTTTTTTTTT TGAGATGGAG 
TTCCACTCTT TTTGCCCAGG CTGGAATGGT GTGATCTCCC GTCACTACAA CCTCCACCTC
CCAGTTGTGG TGACAGTACA TGGAGAGATT GACCCTGCTA CGGGAATGGT TATGAATCTG
GCTGATCTCA AAAAATATAT GGAGGAGGCG ATTATGCAGC CCCTTGATCA TAAGAATCTG
GATATGGATG TGCCATACTT TGCAGATGTG GTGAGCACGA CTGAAAATGT AGCTGTTTAT
ATCTGGGACA ACCTCCAGAA AGTTCTTCCT GTAGGAGTTC TTTATAAAGT AAAAGTATAC
GAAACTGACA ATAATATTGT GGTTTATAAA GGAGAATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011541245.1
CDS684..1082
Misc Feature(1)807..1079(+)
Misc Feature(2)807..1079(+)
Misc Feature(3)1044..1064(+)
Translation

Target ORF information:

RefSeq Version XM_011542943
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011542943

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTGTAAAG CACTGATAAA GTTTTTTTTT GTTGTTGTTG TTTTTTTTTT TGAGATGGAG 
TTCCACTCTT TTTGCCCAGG CTGGAATGGT GTGATCTCCC GTCACTACAA CCTCCACCTC
CCAGTTGTGG TGACAGTACA TGGAGAGATT GACCCTGCTA CGGGAATGGT TATGAATCTG
GCTGATCTCA AAAAATATAT GGAGGAGGCG ATTATGCAGC CCCTTGATCA TAAGAATCTG
GATATGGATG TGCCATACTT TGCAGATGTG GTGAGCACGA CTGAAAATGT AGCTGTTTAT
ATCTGGGACA ACCTCCAGAA AGTTCTTCCT GTAGGAGTTC TTTATAAAGT AAAAGTATAC
GAAACTGACA ATAATATTGT GGTTTATAAA GGAGAATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19651
Clone ID Related Accession (Same CDS sequence) NM_000317
Accession Version NM_000317.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product 6-pyruvoyl tetrahydrobiopterin synthase
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP002884.5, BC009686.1 and CF529329.1. This sequence is a reference standard in the RefSeqGene project. On Jan 12, 2008 this sequence version replaced gi:4506330. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG505490.1, BU596124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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421
ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000308.1
CDS80..517
Misc Feature(1)110..514(+)
Misc Feature(2)110..511(+)
Misc Feature(3)116..508(+)
Misc Feature(4)119..514(+)
Misc Feature(5)134..136(+)
Misc Feature(6)134..136(+)
Misc Feature(7)134..136(+)
Misc Feature(8)149..403(+)
Exon (1)1..162
Gene:PTS
Gene Synonym:
Exon (2)163..242
Gene:PTS
Gene Synonym:
Exon (3)243..265
Gene:PTS
Gene Synonym:
Exon (4)266..322
Gene:PTS
Gene Synonym:
Exon (5)323..393
Gene:PTS
Gene Synonym:
Exon (6)394..935
Gene:PTS
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000317
Organism Homo sapiens (human)
Definition Homo sapiens 6-pyruvoyltetrahydropterin synthase (PTS), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000317

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGAGCACGG AAGGTGGTGG CCGTCGCTGC CAGGCACAAG TGTCCCGCCG CATCTCCTTC 
AGCGCGAGCC ACCGATTGTA CAGTAAATTT CTAAGTGATG AAGAAAACTT GAAACTGTTT
GGGAAATGCA ACAATCCAAA TGGCCATGGG CACAATTATA AAGTTGTGGT GACAGTACAT
GGAGAGATTG ACCCTGCTAC GGGAATGGTT ATGAATCTGG CTGATCTCAA AAAATATATG
GAGGAGGCGA TTATGCAGCC CCTTGATCAT AAGAATCTGG ATATGGATGT GCCATACTTT
GCAGATGTGG TGAGCACGAC TGAAAATGTA GCTGTTTATA TCTGGGACAA CCTCCAGAAA
GTTCTTCCTG TAGGAGTTCT TTATAAAGTA AAAGTATACG AAACTGACAA TAATATTGTG
GTTTATAAAG GAGAATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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