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OPN1LW cDNA ORF clone, Homo sapiens (human)

Gene Symbol OPN1LW
Entrez Gene ID 5956
Full Name opsin 1 (cone pigments), long-wave-sensitive
Synonyms CBBM, CBP, COD5, RCP, ROP
General protein information
Preferred Names
long-wave-sensitive opsin 1
Names
long-wave-sensitive opsin 1
red-sensitive opsin
cone dystrophy 5 (X-linked)
red cone photoreceptor pigment
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300822

Disorder Html: Colorblindness, protan, 303900 (3); Blue cone monochromacy, 303700

mRNA and Protein(s)

mRNA Protein Name
NM_020061 NP_064445 long-wave-sensitive opsin 1

Reactome
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease
R-HSA-2474795 Diseases associated with visual transduction
R-HSA-2453864 Retinoid cycle disease events
R-HSA-162582 Signal Transduction
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signaling
R-HSA-418594 G alpha (i) signalling events
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-2187338 Visual phototransduction
R-HSA-419771 Opsins
R-HSA-2187335 The retinoid cycle in cones (daylight vision)
WikiPathways
WP455 GPCRs, Class A Rhodopsin-like


Homo sapiens (human) OPN1LW NP_064445.2
Pan troglodytes (chimpanzee) OPN1LW XP_003317827.1
Canis lupus familiaris (dog) OPN1LW NP_001184001.1
Bos taurus (cattle) OPN1LW NP_776991.1
Mus musculus (house mouse) Opn1mw NP_032132.1
Rattus norvegicus (Norway rat) Opn1mw NP_446000.1
Gallus gallus (chicken) OPN1LW NP_990771.1
Danio rerio (zebrafish) opn1lw2 NP_001002443.1
Danio rerio (zebrafish) opn1lw1 NP_571250.1
Xenopus (Silurana) tropicalis (western clawed frog) opn1lw NP_001096331.1

Component

ID Name Evidence
GO:0005886 plasma membrane TAS
GO:0005887 integral to plasma membrane TAS

Function

ID Name Evidence
GO:0004930 G-protein coupled receptor activity IEA
GO:0009881 photoreceptor activity IEA

Process

ID Name Evidence
GO:0007165 signal transduction TAS
GO:0007601 visual perception IEA
GO:0007602 phototransduction IEA
GO:0018298 protein-chromophore linkage IEA
GO:0050896 response to stimulus IEA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OPN1LW gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN1LW cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21082 NM_020061 Homo sapiens opsin 1 (cone pigments), long-wave-sensitive (OPN1LW), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu21082
Accession Version NM_020061.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 05-MAY-2014
Organism Homo sapiens (human)
Product long-wave-sensitive opsin 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN693335.1, BQ639996.1, EL949562.1, BM688032.1 and BU726889.1. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2013 this sequence version replaced gi:164419729. Summary: This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749814.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:12051694) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_064445.2
CDS61..1155
Misc Feature(1)217..291(+)
Misc Feature(2)262..>594(+)
Misc Feature(3)286..1026(+)
Misc Feature(4)328..405(+)
Misc Feature(5)448..507(+)
Misc Feature(6)565..636(+)
Misc Feature(7)715..798(+)
Misc Feature(8)865..936(+)
Misc Feature(9)961..1035(+)
Misc Feature(10)994..996(+)
Exon (1)1..172
Gene:OPN1LW
Gene Synonym:
Exon (2)173..469
Gene:OPN1LW
Gene Synonym:
Exon (3)470..638
Gene:OPN1LW
Gene Synonym:
Exon (4)639..804
Gene:OPN1LW
Gene Synonym:
Exon (5)805..1044
Gene:OPN1LW
Gene Synonym:
Exon (6)1045..1261
Gene:OPN1LW
Gene Synonym:
Translation
Position Chain Variation Link
513 513 a, g dbSNP:949430
517 517 a, c dbSNP:713
525 525 a, c, g dbSNP:731614
571 571 a, c, g dbSNP:5986963
573 573 a, g, t dbSNP:5986964
598 598 g, t dbSNP:949431
667 667 c, t dbSNP:121434621
766 766 a, c, g, t dbSNP:1065426
799 799 c, t dbSNP:104894912
1073 1073 a, g dbSNP:104894913

Target ORF information:

RefSeq Version NM_020061
Organism Homo sapiens (human)
Definition Homo sapiens opsin 1 (cone pigments), long-wave-sensitive (OPN1LW), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020061

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Blue cone monochromatism in a female due to skewed X-inactivation
Ophthalmic Genet. 34 (1-2), 101-104 (2013)
Frederiksen AL, Duno M and Welinder LG.


book

The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic
Invest. Ophthalmol. Vis. Sci. 53 (13), 8006-8015 (2012)
Carroll J, Dubra A, Gardner JC, Mizrahi-Meissonnier L, Cooper RF, Dubis AM, Nordgren R, Genead M, Connor TB Jr, Stepien KE, Sharon D, Hunt DM, Banin E, Hardcastle AJ, Moore AT, Williams DR, Fishman G, Neitz J, Neitz M and Michaelides M.


book

Unique haplotype in exon 3 of cone opsin mRNA affects splicing of its precursor, leading to congenital color vision defect
Biochem. Biophys. Res. Commun. 424 (1), 152-157 (2012)
Ueyama H, Muraki-Oda S, Yamade S, Tanabe S, Yamashita T, Shichida Y and Ogita H.


book

A novel missense mutation in both OPN1LW and OPN1MW cone opsin genes causes X-linked cone dystrophy (XLCOD5)
Adv. Exp. Med. Biol. 723, 595-601 (2012)
Gardner JC, Webb TR, Kanuga N, Robson AG, Holder GE, Stockman A, Ripamonti C, Ebenezer ND, Ogun O, Devery S, Wright GA, Maher ER, Cheetham ME, Moore AT, Michaelides M and Hardcastle AJ.


book

Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies
Biochem. Biophys. Res. Commun. 294 (2), 205-209 (2002)
Ueyama H, Kuwayama S, Imai H, Tanabe S, Oda S, Nishida Y, Wada A, Shichida Y and Yamade S.


book

Red-Green Color Vision Defects
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Deeb,S.S. and Motulsky,A.G.


book

Polymorphism in red photopigment underlies variation in colour matching
Nature 356 (6368), 431-433 (1992)
Winderickx J, Lindsey DT, Sanocki E, Teller DY, Motulsky AG and Deeb SS.


book

Completion of the physical map of Xq28: the location of the gene for L1CAM on the human X chromosome
Mamm. Genome 3 (3), 168-172 (1992)
Dietrich A, Korn B and Poustka A.


book

Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region
Genomics 4 (4), 460-471 (1989)
Arveiler B, Vincent A and Mandel JL.


book

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
Science 232 (4747), 193-202 (1986)
Nathans,J., Thomas,D. and Hogness,D.S.


 
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