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OPN1LW opsin 1 (cone pigments), long-wave-sensitive [Homo sapiens (human)]

Gene Symbol OPN1LW
Entrez Gene ID 5956
Full Name opsin 1 (cone pigments), long-wave-sensitive
Synonyms CBBM, CBP, COD5, RCP, ROP
General protein information
Preferred Names
long-wave-sensitive opsin 1
Names
long-wave-sensitive opsin 1
red-sensitive opsin
cone dystrophy 5 (X-linked)
red cone photoreceptor pigment
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300822

Disorder Html: Colorblindness, protan, 303900 (3); Blue cone monochromacy, 303700





The following OPN1LW gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN1LW gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21082 NM_020061 Homo sapiens opsin 1 (cone pigments), long-wave-sensitive (OPN1LW), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu21082
Accession Version NM_020061.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 05-MAY-2014
Organism Homo sapiens (human)
Product long-wave-sensitive opsin 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN693335.1, BQ639996.1, EL949562.1, BM688032.1 and BU726889.1. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2013 this sequence version replaced gi:164419729. Summary: This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR749814.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:12051694) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG
GTATCGCCTG CATGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_064445.2
CDS61..1155
Misc Feature(1)217..291(+)
Misc Feature(2)262..>594(+)
Misc Feature(3)286..1026(+)
Misc Feature(4)328..405(+)
Misc Feature(5)448..507(+)
Misc Feature(6)565..636(+)
Misc Feature(7)715..798(+)
Misc Feature(8)865..936(+)
Misc Feature(9)961..1035(+)
Misc Feature(10)994..996(+)
Exon (1)1..172
Gene:OPN1LW
Gene Synonym:
Exon (2)173..469
Gene:OPN1LW
Gene Synonym:
Exon (3)470..638
Gene:OPN1LW
Gene Synonym:
Exon (4)639..804
Gene:OPN1LW
Gene Synonym:
Exon (5)805..1044
Gene:OPN1LW
Gene Synonym:
Exon (6)1045..1261
Gene:OPN1LW
Gene Synonym:
Translation
Position Chain Variation Link
513 513 a, g dbSNP:949430
517 517 a, c dbSNP:713
525 525 a, c, g dbSNP:731614
571 571 a, c, g dbSNP:5986963
573 573 a, g, t dbSNP:5986964
598 598 g, t dbSNP:949431
667 667 c, t dbSNP:121434621
766 766 a, c, g, t dbSNP:1065426
799 799 c, t dbSNP:104894912
1073 1073 a, g dbSNP:104894913

Target ORF information:

RefSeq Version NM_020061
Organism Homo sapiens (human)
Definition Homo sapiens opsin 1 (cone pigments), long-wave-sensitive (OPN1LW), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_020061

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCAGC AGTGGAGCCT CCAAAGGCTC GCAGGCCGCC ATCCGCAGGA CAGCTATGAG 
GACAGCACCC AGTCCAGCAT CTTCACCTAC ACCAACAGCA ACTCCACCAG AGGCCCCTTC
GAAGGCCCGA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG TGTCTGGATG
ATCTTTGTGG TCACTGCATC CGTCTTCACA AATGGGCTTG TGCTGGCGGC CACCATGAAG
TTCAAGAAGC TGCGCCACCC GCTGAACTGG ATCCTGGTGA ACCTGGCGGT CGCTGACCTA
GCAGAGACCG TCATCGCCAG CACTATCAGC ATTGTGAACC AGGTCTCTGG CTACTTCGTG
CTGGGCCACC CTATGTGTGT CCTGGAGGGC TACACCGTCT CCCTGTGTGG GATCACAGGT
CTCTGGTCTC TGGCCATCAT TTCCTGGGAG AGATGGATGG TGGTCTGCAA GCCCTTTGGC
AATGTGAGAT TTGATGCCAA GCTGGCCATC GTGGGCATTG CCTTCTCCTG GATCTGGGCT
GCTGTGTGGA CAGCCCCGCC CATCTTTGGT TGGAGCAGGT ACTGGCCCCA CGGCCTGAAG
ACTTCATGCG GCCCAGACGT GTTCAGCGGC AGCTCGTACC CCGGGGTGCA GTCTTACATG
ATTGTCCTCA TGGTCACCTG CTGCATCATC CCACTCGCTA TCATCATGCT CTGCTACCTC
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAGTCTGA ATCCACCCAG
AAGGCAGAGA AGGAAGTGAC GCGCATGGTG GTGGTGATGA TCTTTGCGTA CTGCGTCTGC
TGGGGACCCT ACACCTTCTT CGCATGCTTT GCTGCTGCCA ACCCTGGTTA CGCCTTCCAC
CCTTTGATGG CTGCCCTGCC GGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCGTT
ATCTATGTCT TTATGAACCG GCAGTTTCGA AACTGCATCT TGCAGCTTTT CGGGAAGAAG
GTTGACGATG GCTCTGAACT CTCCAGCGCC TCCAAAACGG AGGTCTCATC TGTGTCCTCG
GTATCGCCTG CATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.