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BCR cDNA ORF clone, Homo sapiens (human)

Gene Symbol BCR
Entrez Gene ID 613
Full Name breakpoint cluster region
Synonyms ALL, BCR1, CML, D22S11, D22S662, PHL
General protein information
Preferred Names
breakpoint cluster region protein
Names
breakpoint cluster region protein
BCR/FGFR1 chimera protein
FGFR1/BCR chimera protein
renal carcinoma antigen NY-REN-26
NP_004318.3
NP_067585.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q11.23

Summary A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

151410

Disorder Html: Leukemia, chronic myeloid, 608232 (3); Leukemia, acute lymphocytic,

mRNA and Protein(s)

mRNA Protein Name
NM_004327 NP_004318 breakpoint cluster region protein isoform 1
NM_021574 NP_067585 breakpoint cluster region protein isoform 2



Homo sapiens (human) BCR NP_004318.3
Pan troglodytes (chimpanzee) BCR XP_003317181.1
Macaca mulatta (Rhesus monkey) BCR XP_002798337.1
Canis lupus familiaris (dog) BCR XP_848654.2
Mus musculus (house mouse) Bcr NP_001074881.1
Rattus norvegicus (Norway rat) Bcr XP_228091.6
Gallus gallus (chicken) BCR XP_415244.3
Danio rerio (zebrafish) bcr XP_005161278.1
Xenopus (Silurana) tropicalis (western clawed frog) bcr NP_001123792.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following BCR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25583 NM_004327 Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $895.30
$1279.00
OHu25516 NM_021574 Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $643.30
$919.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25583
Clone ID Related Accession (Same CDS sequence) NM_004327
Accession Version NM_004327.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3816bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product breakpoint cluster region protein isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U07000.1, BC066122.1, BQ422888.1 and X02596.1. This sequence is a reference standard in the RefSeqGene project. On Nov 18, 2005 this sequence version replaced gi:11038638. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02596.1, BC066122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
ATGGTGGACC CGGTGGGCTT CGCGGAGGCG TGGAAGGCGC AGTTCCCGGA CTCAGAGCCC 
CCGCGCATGG AGCTGCGCTC AGTGGGCGAC ATCGAGCAGG AGCTGGAGCG CTGCAAGGCC
TCCATTCGGC GCCTGGAGCA GGAGGTGAAC CAGGAGCGCT TCCGCATGAT CTACCTGCAG
ACGTTGCTGG CCAAGGAAAA GAAGAGCTAT GACCGGCAGC GATGGGGCTT CCGGCGCGCG
GCGCAGGCCC CCGACGGCGC CTCCGAGCCC CGAGCGTCCG CGTCGCGCCC GCAGCCAGCG
CCCGCCGACG GAGCCGACCC GCCGCCCGCC GAGGAGCCCG AGGCCCGGCC CGACGGCGAG
GGTTCTCCGG GTAAGGCCAG GCCCGGGACC GCCCGCAGGC CCGGGGCAGC CGCGTCGGGG
GAACGGGACG ACCGGGGACC CCCCGCCAGC GTGGCGGCGC TCAGGTCCAA CTTCGAGCGG
ATCCGCAAGG GCCATGGCCA GCCCGGGGCG GACGCCGAGA AGCCCTTCTA CGTGAACGTC
GAGTTTCACC ACGAGCGCGG CCTGGTGAAG GTCAACGACA AAGAGGTGTC GGACCGCATC
AGCTCCCTGG GCAGCCAGGC CATGCAGATG GAGCGCAAAA AGTCCCAGCA CGGCGCGGGC
TCGAGCGTGG GGGATGCATC CAGGCCCCCT TACCGGGGAC GCTCCTCGGA GAGCAGCTGC
GGCGTCGACG GCGACTACGA GGACGCCGAG TTGAACCCCC GCTTCCTGAA GGACAACCTG
ATCGACGCCA ATGGCGGTAG CAGGCCCCCT TGGCCGCCCC TGGAGTACCA GCCCTACCAG
AGCATCTACG TCGGGGGCAT GATGGAAGGG GAGGGCAAGG GCCCGCTCCT GCGCAGCCAG
AGCACCTCTG AGCAGGAGAA GCGCCTTACC TGGCCCCGCA GGTCCTACTC CCCCCGGAGT
TTTGAGGATT GCGGAGGCGG CTATACCCCG GACTGCAGCT CCAATGAGAA CCTCACCTCC
AGCGAGGAGG ACTTCTCCTC TGGCCAGTCC AGCCGCGTGT CCCCAAGCCC CACCACCTAC
CGCATGTTCC GGGACAAAAG CCGCTCTCCC TCGCAGAACT CGCAACAGTC CTTCGACAGC
AGCAGTCCCC CCACGCCGCA GTGCCATAAG CGGCACCGGC ACTGCCCGGT TGTCGTGTCC
GAGGCCACCA TCGTGGGCGT CCGCAAGACC GGGCAGATCT GGCCCAACGA TGGCGAGGGC
GCCTTCCATG GAGACGCAGA TGGCTCGTTC GGAACACCAC CTGGATACGG CTGCGCTGCA
GACCGGGCAG AGGAGCAGCG CCGGCACCAA GATGGGCTGC CCTACATTGA TGACTCGCCC
TCCTCATCGC CCCACCTCAG CAGCAAGGGC AGGGGCAGCC GGGATGCGCT GGTCTCGGGA
GCCCTGGAGT CCACTAAAGC GAGTGAGCTG GACTTGGAAA AGGGCTTGGA GATGAGAAAA
TGGGTCCTGT CGGGAATCCT GGCTAGCGAG GAGACTTACC TGAGCCACCT GGAGGCACTG
CTGCTGCCCA TGAAGCCTTT GAAAGCCGCT GCCACCACCT CTCAGCCGGT GCTGACGAGT
CAGCAGATCG AGACCATCTT CTTCAAAGTG CCTGAGCTCT ACGAGATCCA CAAGGAGTTC
TATGATGGGC TCTTCCCCCG CGTGCAGCAG TGGAGCCACC AGCAGCGGGT GGGCGACCTC
TTCCAGAAGC TGGCCAGCCA GCTGGGTGTG TACCGGGCCT TCGTGGACAA CTACGGAGTT
GCCATGGAAA TGGCTGAGAA GTGCTGTCAG GCCAATGCTC AGTTTGCAGA AATCTCCGAG
AACCTGAGAG CCAGAAGCAA CAAAGATGCC AAGGATCCAA CGACCAAGAA CTCTCTGGAA
ACTCTGCTCT ACAAGCCTGT GGACCGTGTG ACGAGGAGCA CGCTGGTCCT CCATGACTTG
CTGAAGCACA CTCCTGCCAG CCACCCTGAC CACCCCTTGC TGCAGGACGC CCTCCGCATC
TCACAGAACT TCCTGTCCAG CATCAATGAG GAGATCACAC CCCGACGGCA GTCCATGACG
GTGAAGAAGG GAGAGCACCG GCAGCTGCTG AAGGACAGCT TCATGGTGGA GCTGGTGGAG
GGGGCCCGCA AGCTGCGCCA CGTCTTCCTG TTCACCGACC TGCTTCTCTG CACCAAGCTC
AAGAAGCAGA GCGGAGGCAA AACGCAGCAG TATGACTGCA AATGGTACAT TCCGCTCACG
GATCTCAGCT TCCAGATGGT GGATGAACTG GAGGCAGTGC CCAACATCCC CCTGGTGCCC
GATGAGGAGC TGGACGCTTT GAAGATCAAG ATCTCCCAGA TCAAGAATGA CATCCAGAGA
GAGAAGAGGG CGAACAAGGG CAGCAAGGCT ACGGAGAGGC TGAAGAAGAA GCTGTCGGAG
CAGGAGTCAC TGCTGCTGCT TATGTCTCCC AGCATGGCCT TCAGGGTGCA CAGCCGCAAC
GGCAAGAGTT ACACGTTCCT GATCTCCTCT GACTATGAGC GTGCAGAGTG GAGGGAGAAC
ATCCGGGAGC AGCAGAAGAA GTGTTTCAGA AGCTTCTCCC TGACATCCGT GGAGCTGCAG
ATGCTGACCA ACTCGTGTGT GAAACTCCAG ACTGTCCACA GCATTCCGCT GACCATCAAT
AAGGAAGATG ATGAGTCTCC GGGGCTCTAT GGGTTTCTGA ATGTCATCGT CCACTCAGCC
ACTGGATTTA AGCAGAGTTC AAATCTGTAC TGCACCCTGG AGGTGGATTC CTTTGGGTAT
TTTGTGAATA AAGCAAAGAC GCGCGTCTAC AGGGACACAG CTGAGCCAAA CTGGAACGAG
GAATTTGAGA TAGAGCTGGA GGGCTCCCAG ACCCTGAGGA TACTGTGCTA TGAAAAGTGT
TACAACAAGA CGAAGATCCC CAAGGAGGAC GGCGAGAGCA CGGACAGACT CATGGGGAAG
GGCCAGGTCC AGCTGGACCC GCAGGCCCTG CAGGACAGAG ACTGGCAGCG CACCGTCATC
GCCATGAATG GGATCGAAGT AAAGCTCTCG GTCAAGTTCA ACAGCAGGGA GTTCAGCTTG
AAGAGGATGC CGTCCCGAAA ACAGACAGGG GTCTTCGGAG TCAAGATTGC TGTGGTCACC
AAGAGAGAGA GGTCCAAGGT GCCCTACATC GTGCGCCAGT GCGTGGAGGA GATCGAGCGC
CGAGGCATGG AGGAGGTGGG CATCTACCGC GTGTCCGGTG TGGCCACGGA CATCCAGGCA
CTGAAGGCAG CCTTCGACGT CAATAACAAG GACGTGTCGG TGATGATGAG CGAGATGGAC
GTGAACGCCA TCGCAGGCAC GCTGAAGCTG TACTTCCGTG AGCTGCCCGA GCCCCTCTTC
ACTGACGAGT TCTACCCCAA CTTCGCAGAG GGCATCGCTC TTTCAGACCC GGTTGCAAAG
GAGAGCTGCA TGCTCAACCT GCTGCTGTCC CTGCCGGAGG CCAACCTGCT CACCTTCCTT
TTCCTTCTGG ACCACCTGAA AAGGGTGGCA GAGAAGGAGG CAGTCAATAA GATGTCCCTG
CACAACCTCG CCACGGTCTT TGGCCCCACG CTGCTCCGGC CCTCCGAGAA GGAGAGCAAG
CTCCCTGCCA ACCCCAGCCA GCCTATCACC ATGACTGACA GCTGGTCCTT GGAGGTCATG
TCCCAGGTCC AGGTGCTGCT GTACTTCCTG CAGCTGGAGG CCATCCCTGC CCCGGACAGC
AAGAGACAGA GCATCCTGTT CTCCACCGAA GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004318.3
CDS597..4412
Misc Feature(1)546..548(+)
Misc Feature(2)597..1874(+)
Misc Feature(3)597..599(+)
Misc Feature(4)600..812(+)
Misc Feature(5)882..1100(+)
Misc Feature(6)960..962(+)
Misc Feature(7)1125..1127(+)
Misc Feature(8)1125..1127(+)
Misc Feature(9)1125..1127(+)
Misc Feature(10)1125..1127(+)
Misc Feature(11)1185..1751(+)
Misc Feature(12)1239..1241(+)
Misc Feature(13)1332..1334(+)
Misc Feature(14)1332..1334(+)
Misc Feature(15)1422..1424(+)
Misc Feature(16)1431..1433(+)
Misc Feature(17)1443..1445(+)
Misc Feature(18)1524..1526(+)
Misc Feature(19)1578..1580(+)
Misc Feature(20)1656..1658(+)
Misc Feature(21)1674..1676(+)
Misc Feature(22)1872..1877(+)
Misc Feature(23)1971..1973(+)
Misc Feature(24)1971..1973(+)
Misc Feature(25)1983..1985(+)
Misc Feature(26)1995..1997(+)
Misc Feature(27)2091..2663(+)
Misc Feature(28)2109..2663(+)
Misc Feature(29)2367..2369(+)
Misc Feature(30)2526..2528(+)
Misc Feature(31)2646..3227(+)
Misc Feature(32)3333..3695(+)
Misc Feature(33)3750..4352(+)
Misc Feature(34)3864..4325(+)
Misc Feature(35)3864..3866(+)
Misc Feature(36)4386..4388(+)
Exon (1)1..1875
Gene:BCR
Gene Synonym:
Exon (2)1876..2057
Gene:BCR
Gene Synonym:
Exon (3)2058..2162
Gene:BCR
Gene Synonym:
Exon (4)2163..2348
Gene:BCR
Gene Synonym:
Exon (5)2349..2456
Gene:BCR
Gene Synonym:
Exon (6)2457..2517
Gene:BCR
Gene Synonym:
Exon (7)2518..2570
Gene:BCR
Gene Synonym:
Exon (8)2571..2711
Gene:BCR
Gene Synonym:
Exon (9)2712..2833
Gene:BCR
Gene Synonym:
Exon (10)2834..3002
Gene:BCR
Gene Synonym:
Exon (11)3003..3122
Gene:BCR
Gene Synonym:
Exon (12)3123..3198
Gene:BCR
Gene Synonym:
Exon (13)3199..3303
Gene:BCR
Gene Synonym:
Exon (14)3304..3378
Gene:BCR
Gene Synonym:
Exon (15)3379..3476
Gene:BCR
Gene Synonym:
Exon (16)3477..3608
Gene:BCR
Gene Synonym:
Exon (17)3609..3668
Gene:BCR
Gene Synonym:
Exon (18)3669..3778
Gene:BCR
Gene Synonym:
Exon (19)3779..3918
Gene:BCR
Gene Synonym:
Exon (20)3919..4053
Gene:BCR
Gene Synonym:
Exon (21)4054..4159
Gene:BCR
Gene Synonym:
Exon (22)4160..4322
Gene:BCR
Gene Synonym:
Exon (23)4323..6927
Gene:BCR
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004327
Organism Homo sapiens (human)
Definition Homo sapiens breakpoint cluster region (BCR), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004327

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
ATGGTGGACC CGGTGGGCTT CGCGGAGGCG TGGAAGGCGC AGTTCCCGGA CTCAGAGCCC 
CCGCGCATGG AGCTGCGCTC AGTGGGCGAC ATCGAGCAGG AGCTGGAGCG CTGCAAGGCC
TCCATTCGGC GCCTGGAGCA GGAGGTGAAC CAGGAGCGCT TCCGCATGAT CTACCTGCAG
ACGTTGCTGG CCAAGGAAAA GAAGAGCTAT GACCGGCAGC GATGGGGCTT CCGGCGCGCG
GCGCAGGCCC CCGACGGCGC CTCCGAGCCC CGAGCGTCCG CGTCGCGCCC GCAGCCAGCG
CCCGCCGACG GAGCCGACCC GCCGCCCGCC GAGGAGCCCG AGGCCCGGCC CGACGGCGAG
GGTTCTCCGG GTAAGGCCAG GCCCGGGACC GCCCGCAGGC CCGGGGCAGC CGCGTCGGGG
GAACGGGACG ACCGGGGACC CCCCGCCAGC GTGGCGGCGC TCAGGTCCAA CTTCGAGCGG
ATCCGCAAGG GCCATGGCCA GCCCGGGGCG GACGCCGAGA AGCCCTTCTA CGTGAACGTC
GAGTTTCACC ACGAGCGCGG CCTGGTGAAG GTCAACGACA AAGAGGTGTC GGACCGCATC
AGCTCCCTGG GCAGCCAGGC CATGCAGATG GAGCGCAAAA AGTCCCAGCA CGGCGCGGGC
TCGAGCGTGG GGGATGCATC CAGGCCCCCT TACCGGGGAC GCTCCTCGGA GAGCAGCTGC
GGCGTCGACG GCGACTACGA GGACGCCGAG TTGAACCCCC GCTTCCTGAA GGACAACCTG
ATCGACGCCA ATGGCGGTAG CAGGCCCCCT TGGCCGCCCC TGGAGTACCA GCCCTACCAG
AGCATCTACG TCGGGGGCAT GATGGAAGGG GAGGGCAAGG GCCCGCTCCT GCGCAGCCAG
AGCACCTCTG AGCAGGAGAA GCGCCTTACC TGGCCCCGCA GGTCCTACTC CCCCCGGAGT
TTTGAGGATT GCGGAGGCGG CTATACCCCG GACTGCAGCT CCAATGAGAA CCTCACCTCC
AGCGAGGAGG ACTTCTCCTC TGGCCAGTCC AGCCGCGTGT CCCCAAGCCC CACCACCTAC
CGCATGTTCC GGGACAAAAG CCGCTCTCCC TCGCAGAACT CGCAACAGTC CTTCGACAGC
AGCAGTCCCC CCACGCCGCA GTGCCATAAG CGGCACCGGC ACTGCCCGGT TGTCGTGTCC
GAGGCCACCA TCGTGGGCGT CCGCAAGACC GGGCAGATCT GGCCCAACGA TGGCGAGGGC
GCCTTCCATG GAGACGCAGA TGGCTCGTTC GGAACACCAC CTGGATACGG CTGCGCTGCA
GACCGGGCAG AGGAGCAGCG CCGGCACCAA GATGGGCTGC CCTACATTGA TGACTCGCCC
TCCTCATCGC CCCACCTCAG CAGCAAGGGC AGGGGCAGCC GGGATGCGCT GGTCTCGGGA
GCCCTGGAGT CCACTAAAGC GAGTGAGCTG GACTTGGAAA AGGGCTTGGA GATGAGAAAA
TGGGTCCTGT CGGGAATCCT GGCTAGCGAG GAGACTTACC TGAGCCACCT GGAGGCACTG
CTGCTGCCCA TGAAGCCTTT GAAAGCCGCT GCCACCACCT CTCAGCCGGT GCTGACGAGT
CAGCAGATCG AGACCATCTT CTTCAAAGTG CCTGAGCTCT ACGAGATCCA CAAGGAGTTC
TATGATGGGC TCTTCCCCCG CGTGCAGCAG TGGAGCCACC AGCAGCGGGT GGGCGACCTC
TTCCAGAAGC TGGCCAGCCA GCTGGGTGTG TACCGGGCCT TCGTGGACAA CTACGGAGTT
GCCATGGAAA TGGCTGAGAA GTGCTGTCAG GCCAATGCTC AGTTTGCAGA AATCTCCGAG
AACCTGAGAG CCAGAAGCAA CAAAGATGCC AAGGATCCAA CGACCAAGAA CTCTCTGGAA
ACTCTGCTCT ACAAGCCTGT GGACCGTGTG ACGAGGAGCA CGCTGGTCCT CCATGACTTG
CTGAAGCACA CTCCTGCCAG CCACCCTGAC CACCCCTTGC TGCAGGACGC CCTCCGCATC
TCACAGAACT TCCTGTCCAG CATCAATGAG GAGATCACAC CCCGACGGCA GTCCATGACG
GTGAAGAAGG GAGAGCACCG GCAGCTGCTG AAGGACAGCT TCATGGTGGA GCTGGTGGAG
GGGGCCCGCA AGCTGCGCCA CGTCTTCCTG TTCACCGACC TGCTTCTCTG CACCAAGCTC
AAGAAGCAGA GCGGAGGCAA AACGCAGCAG TATGACTGCA AATGGTACAT TCCGCTCACG
GATCTCAGCT TCCAGATGGT GGATGAACTG GAGGCAGTGC CCAACATCCC CCTGGTGCCC
GATGAGGAGC TGGACGCTTT GAAGATCAAG ATCTCCCAGA TCAAGAATGA CATCCAGAGA
GAGAAGAGGG CGAACAAGGG CAGCAAGGCT ACGGAGAGGC TGAAGAAGAA GCTGTCGGAG
CAGGAGTCAC TGCTGCTGCT TATGTCTCCC AGCATGGCCT TCAGGGTGCA CAGCCGCAAC
GGCAAGAGTT ACACGTTCCT GATCTCCTCT GACTATGAGC GTGCAGAGTG GAGGGAGAAC
ATCCGGGAGC AGCAGAAGAA GTGTTTCAGA AGCTTCTCCC TGACATCCGT GGAGCTGCAG
ATGCTGACCA ACTCGTGTGT GAAACTCCAG ACTGTCCACA GCATTCCGCT GACCATCAAT
AAGGAAGATG ATGAGTCTCC GGGGCTCTAT GGGTTTCTGA ATGTCATCGT CCACTCAGCC
ACTGGATTTA AGCAGAGTTC AAATCTGTAC TGCACCCTGG AGGTGGATTC CTTTGGGTAT
TTTGTGAATA AAGCAAAGAC GCGCGTCTAC AGGGACACAG CTGAGCCAAA CTGGAACGAG
GAATTTGAGA TAGAGCTGGA GGGCTCCCAG ACCCTGAGGA TACTGTGCTA TGAAAAGTGT
TACAACAAGA CGAAGATCCC CAAGGAGGAC GGCGAGAGCA CGGACAGACT CATGGGGAAG
GGCCAGGTCC AGCTGGACCC GCAGGCCCTG CAGGACAGAG ACTGGCAGCG CACCGTCATC
GCCATGAATG GGATCGAAGT AAAGCTCTCG GTCAAGTTCA ACAGCAGGGA GTTCAGCTTG
AAGAGGATGC CGTCCCGAAA ACAGACAGGG GTCTTCGGAG TCAAGATTGC TGTGGTCACC
AAGAGAGAGA GGTCCAAGGT GCCCTACATC GTGCGCCAGT GCGTGGAGGA GATCGAGCGC
CGAGGCATGG AGGAGGTGGG CATCTACCGC GTGTCCGGTG TGGCCACGGA CATCCAGGCA
CTGAAGGCAG CCTTCGACGT CAATAACAAG GACGTGTCGG TGATGATGAG CGAGATGGAC
GTGAACGCCA TCGCAGGCAC GCTGAAGCTG TACTTCCGTG AGCTGCCCGA GCCCCTCTTC
ACTGACGAGT TCTACCCCAA CTTCGCAGAG GGCATCGCTC TTTCAGACCC GGTTGCAAAG
GAGAGCTGCA TGCTCAACCT GCTGCTGTCC CTGCCGGAGG CCAACCTGCT CACCTTCCTT
TTCCTTCTGG ACCACCTGAA AAGGGTGGCA GAGAAGGAGG CAGTCAATAA GATGTCCCTG
CACAACCTCG CCACGGTCTT TGGCCCCACG CTGCTCCGGC CCTCCGAGAA GGAGAGCAAG
CTCCCTGCCA ACCCCAGCCA GCCTATCACC ATGACTGACA GCTGGTCCTT GGAGGTCATG
TCCCAGGTCC AGGTGCTGCT GTACTTCCTG CAGCTGGAGG CCATCCCTGC CCCGGACAGC
AAGAGACAGA GCATCCTGTT CTCCACCGAA GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25516
Clone ID Related Accession (Same CDS sequence) NM_021574
Accession Version NM_021574.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3684bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product breakpoint cluster region protein isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U07000.1, BC066122.1, BQ422888.1 and Y00661.1. On or before Mar 15, 2007 this sequence version replaced gi:113429385, gi:11038640. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y00661.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
ATGGTGGACC CGGTGGGCTT CGCGGAGGCG TGGAAGGCGC AGTTCCCGGA CTCAGAGCCC 
CCGCGCATGG AGCTGCGCTC AGTGGGCGAC ATCGAGCAGG AGCTGGAGCG CTGCAAGGCC
TCCATTCGGC GCCTGGAGCA GGAGGTGAAC CAGGAGCGCT TCCGCATGAT CTACCTGCAG
ACGTTGCTGG CCAAGGAAAA GAAGAGCTAT GACCGGCAGC GATGGGGCTT CCGGCGCGCG
GCGCAGGCCC CCGACGGCGC CTCCGAGCCC CGAGCGTCCG CGTCGCGCCC GCAGCCAGCG
CCCGCCGACG GAGCCGACCC GCCGCCCGCC GAGGAGCCCG AGGCCCGGCC CGACGGCGAG
GGTTCTCCGG GTAAGGCCAG GCCCGGGACC GCCCGCAGGC CCGGGGCAGC CGCGTCGGGG
GAACGGGACG ACCGGGGACC CCCCGCCAGC GTGGCGGCGC TCAGGTCCAA CTTCGAGCGG
ATCCGCAAGG GCCATGGCCA GCCCGGGGCG GACGCCGAGA AGCCCTTCTA CGTGAACGTC
GAGTTTCACC ACGAGCGCGG CCTGGTGAAG GTCAACGACA AAGAGGTGTC GGACCGCATC
AGCTCCCTGG GCAGCCAGGC CATGCAGATG GAGCGCAAAA AGTCCCAGCA CGGCGCGGGC
TCGAGCGTGG GGGATGCATC CAGGCCCCCT TACCGGGGAC GCTCCTCGGA GAGCAGCTGC
GGCGTCGACG GCGACTACGA GGACGCCGAG TTGAACCCCC GCTTCCTGAA GGACAACCTG
ATCGACGCCA ATGGCGGTAG CAGGCCCCCT TGGCCGCCCC TGGAGTACCA GCCCTACCAG
AGCATCTACG TCGGGGGCAT GATGGAAGGG GAGGGCAAGG GCCCGCTCCT GCGCAGCCAG
AGCACCTCTG AGCAGGAGAA GCGCCTTACC TGGCCCCGCA GGTCCTACTC CCCCCGGAGT
TTTGAGGATT GCGGAGGCGG CTATACCCCG GACTGCAGCT CCAATGAGAA CCTCACCTCC
AGCGAGGAGG ACTTCTCCTC TGGCCAGTCC AGCCGCGTGT CCCCAAGCCC CACCACCTAC
CGCATGTTCC GGGACAAAAG CCGCTCTCCC TCGCAGAACT CGCAACAGTC CTTCGACAGC
AGCAGTCCCC CCACGCCGCA GTGCCATAAG CGGCACCGGC ACTGCCCGGT TGTCGTGTCC
GAGGCCACCA TCGTGGGCGT CCGCAAGACC GGGCAGATCT GGCCCAACGA TGGCGAGGGC
GCCTTCCATG GAGACGCAGA TGGCTCGTTC GGAACACCAC CTGGATACGG CTGCGCTGCA
GACCGGGCAG AGGAGCAGCG CCGGCACCAA GATGGGCTGC CCTACATTGA TGACTCGCCC
TCCTCATCGC CCCACCTCAG CAGCAAGGGC AGGGGCAGCC GGGATGCGCT GGTCTCGGGA
GCCCTGGAGT CCACTAAAGC GAGTGAGCTG GACTTGGAAA AGGGCTTGGA GATGAGAAAA
TGGGTCCTGT CGGGAATCCT GGCTAGCGAG GAGACTTACC TGAGCCACCT GGAGGCACTG
CTGCTGCCCA TGAAGCCTTT GAAAGCCGCT GCCACCACCT CTCAGCCGGT GCTGACGAGT
CAGCAGATCG AGACCATCTT CTTCAAAGTG CCTGAGCTCT ACGAGATCCA CAAGGAGTTC
TATGATGGGC TCTTCCCCCG CGTGCAGCAG TGGAGCCACC AGCAGCGGGT GGGCGACCTC
TTCCAGAAGC TGGCCAGCCA GCTGGGTGTG TACCGGGCCT TCGTGGACAA CTACGGAGTT
GCCATGGAAA TGGCTGAGAA GTGCTGTCAG GCCAATGCTC AGTTTGCAGA AATCTCCGAG
AACCTGAGAG CCAGAAGCAA CAAAGATGCC AAGGATCCAA CGACCAAGAA CTCTCTGGAA
ACTCTGCTCT ACAAGCCTGT GGACCGTGTG ACGAGGAGCA CGCTGGTCCT CCATGACTTG
CTGAAGCACA CTCCTGCCAG CCACCCTGAC CACCCCTTGC TGCAGGACGC CCTCCGCATC
TCACAGAACT TCCTGTCCAG CATCAATGAG GAGATCACAC CCCGACGGCA GTCCATGACG
GTGAAGAAGG GAGAGCACCG GCAGCTGCTG AAGGACAGCT TCATGGTGGA GCTGGTGGAG
GGGGCCCGCA AGCTGCGCCA CGTCTTCCTG TTCACCGACC TGCTTCTCTG CACCAAGCTC
AAGAAGCAGA GCGGAGGCAA AACGCAGCAG TATGACTGCA AATGGTACAT TCCGCTCACG
GATCTCAGCT TCCAGATGGT GGATGAACTG GAGGCAGTGC CCAACATCCC CCTGGTGCCC
GATGAGGAGC TGGACGCTTT GAAGATCAAG ATCTCCCAGA TCAAGAATGA CATCCAGAGA
GAGAAGAGGG CGAACAAGGG CAGCAAGGCT ACGGAGAGGC TGAAGAAGAA GCTGTCGGAG
CAGGAGTCAC TGCTGCTGCT TATGTCTCCC AGCATGGCCT TCAGGGTGCA CAGCCGCAAC
GGCAAGAGTT ACACGTTCCT GATCTCCTCT GACTATGAGC GTGCAGAGTG GAGGGAGAAC
ATCCGGGAGC AGCAGAAGAA GTGTTTCAGA AGCTTCTCCC TGACATCCGT GGAGCTGCAG
ATGCTGACCA ACTCGTGTGT GAAACTCCAG ACTGTCCACA GCATTCCGCT GACCATCAAT
AAGGAAGATG ATGAGTCTCC GGGGCTCTAT GGGTTTCTGA ATGTCATCGT CCACTCAGCC
ACTGGATTTA AGCAGAGTTC AAATCTGTAC TGCACCCTGG AGGTGGATTC CTTTGGGTAT
TTTGTGAATA AAGCAAAGAC GCGCGTCTAC AGGGACACAG CTGAGCCAAA CTGGAACGAG
CTGGACCCGC AGGCCCTGCA GGACAGAGAC TGGCAGCGCA CCGTCATCGC CATGAATGGG
ATCGAAGTAA AGCTCTCGGT CAAGTTCAAC AGCAGGGAGT TCAGCTTGAA GAGGATGCCG
TCCCGAAAAC AGACAGGGGT CTTCGGAGTC AAGATTGCTG TGGTCACCAA GAGAGAGAGG
TCCAAGGTGC CCTACATCGT GCGCCAGTGC GTGGAGGAGA TCGAGCGCCG AGGCATGGAG
GAGGTGGGCA TCTACCGCGT GTCCGGTGTG GCCACGGACA TCCAGGCACT GAAGGCAGCC
TTCGACGTCA ATAACAAGGA CGTGTCGGTG ATGATGAGCG AGATGGACGT GAACGCCATC
GCAGGCACGC TGAAGCTGTA CTTCCGTGAG CTGCCCGAGC CCCTCTTCAC TGACGAGTTC
TACCCCAACT TCGCAGAGGG CATCGCTCTT TCAGACCCGG TTGCAAAGGA GAGCTGCATG
CTCAACCTGC TGCTGTCCCT GCCGGAGGCC AACCTGCTCA CCTTCCTTTT CCTTCTGGAC
CACCTGAAAA GGGTGGCAGA GAAGGAGGCA GTCAATAAGA TGTCCCTGCA CAACCTCGCC
ACGGTCTTTG GCCCCACGCT GCTCCGGCCC TCCGAGAAGG AGAGCAAGCT CCCTGCCAAC
CCCAGCCAGC CTATCACCAT GACTGACAGC TGGTCCTTGG AGGTCATGTC CCAGGTCCAG
GTGCTGCTGT ACTTCCTGCA GCTGGAGGCC ATCCCTGCCC CGGACAGCAA GAGACAGAGC
ATCCTGTTCT CCACCGAAGT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_067585.2
CDS597..4280
Misc Feature(1)546..548(+)
Misc Feature(2)600..812(+)
Misc Feature(3)882..1100(+)
Misc Feature(4)1125..1127(+)
Misc Feature(5)1125..1127(+)
Misc Feature(6)1332..1334(+)
Misc Feature(7)1422..1424(+)
Misc Feature(8)1431..1433(+)
Misc Feature(9)1443..1445(+)
Misc Feature(10)1524..1526(+)
Misc Feature(11)1578..1580(+)
Misc Feature(12)1656..1658(+)
Misc Feature(13)1674..1676(+)
Misc Feature(14)1971..1973(+)
Misc Feature(15)1983..1985(+)
Misc Feature(16)1995..1997(+)
Misc Feature(17)2091..2663(+)
Misc Feature(18)2109..2663(+)
Misc Feature(19)2367..2369(+)
Misc Feature(20)2526..2528(+)
Misc Feature(21)2646..3227(+)
Misc Feature(22)3333..3563(+)
Misc Feature(23)3618..4220(+)
Misc Feature(24)3732..4193(+)
Misc Feature(25)3732..3734(+)
Exon (1)1..1875
Gene:BCR
Gene Synonym:
Exon (2)1876..2057
Gene:BCR
Gene Synonym:
Exon (3)2058..2162
Gene:BCR
Gene Synonym:
Exon (4)2163..2348
Gene:BCR
Gene Synonym:
Exon (5)2349..2456
Gene:BCR
Gene Synonym:
Exon (6)2457..2517
Gene:BCR
Gene Synonym:
Exon (7)2518..2570
Gene:BCR
Gene Synonym:
Exon (8)2571..2711
Gene:BCR
Gene Synonym:
Exon (9)2712..2833
Gene:BCR
Gene Synonym:
Exon (10)2834..3002
Gene:BCR
Gene Synonym:
Exon (11)3003..3122
Gene:BCR
Gene Synonym:
Exon (12)3123..3198
Gene:BCR
Gene Synonym:
Exon (13)3199..3303
Gene:BCR
Gene Synonym:
Exon (14)3304..3378
Gene:BCR
Gene Synonym:
Exon (15)3379..3476
Gene:BCR
Gene Synonym:
Exon (16)3477..3536
Gene:BCR
Gene Synonym:
Exon (17)3537..3646
Gene:BCR
Gene Synonym:
Exon (18)3647..3786
Gene:BCR
Gene Synonym:
Exon (19)3787..3921
Gene:BCR
Gene Synonym:
Exon (20)3922..4027
Gene:BCR
Gene Synonym:
Exon (21)4028..4190
Gene:BCR
Gene Synonym:
Exon (22)4191..6795
Gene:BCR
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_021574
Organism Homo sapiens (human)
Definition Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021574

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
ATGGTGGACC CGGTGGGCTT CGCGGAGGCG TGGAAGGCGC AGTTCCCGGA CTCAGAGCCC 
CCGCGCATGG AGCTGCGCTC AGTGGGCGAC ATCGAGCAGG AGCTGGAGCG CTGCAAGGCC
TCCATTCGGC GCCTGGAGCA GGAGGTGAAC CAGGAGCGCT TCCGCATGAT CTACCTGCAG
ACGTTGCTGG CCAAGGAAAA GAAGAGCTAT GACCGGCAGC GATGGGGCTT CCGGCGCGCG
GCGCAGGCCC CCGACGGCGC CTCCGAGCCC CGAGCGTCCG CGTCGCGCCC GCAGCCAGCG
CCCGCCGACG GAGCCGACCC GCCGCCCGCC GAGGAGCCCG AGGCCCGGCC CGACGGCGAG
GGTTCTCCGG GTAAGGCCAG GCCCGGGACC GCCCGCAGGC CCGGGGCAGC CGCGTCGGGG
GAACGGGACG ACCGGGGACC CCCCGCCAGC GTGGCGGCGC TCAGGTCCAA CTTCGAGCGG
ATCCGCAAGG GCCATGGCCA GCCCGGGGCG GACGCCGAGA AGCCCTTCTA CGTGAACGTC
GAGTTTCACC ACGAGCGCGG CCTGGTGAAG GTCAACGACA AAGAGGTGTC GGACCGCATC
AGCTCCCTGG GCAGCCAGGC CATGCAGATG GAGCGCAAAA AGTCCCAGCA CGGCGCGGGC
TCGAGCGTGG GGGATGCATC CAGGCCCCCT TACCGGGGAC GCTCCTCGGA GAGCAGCTGC
GGCGTCGACG GCGACTACGA GGACGCCGAG TTGAACCCCC GCTTCCTGAA GGACAACCTG
ATCGACGCCA ATGGCGGTAG CAGGCCCCCT TGGCCGCCCC TGGAGTACCA GCCCTACCAG
AGCATCTACG TCGGGGGCAT GATGGAAGGG GAGGGCAAGG GCCCGCTCCT GCGCAGCCAG
AGCACCTCTG AGCAGGAGAA GCGCCTTACC TGGCCCCGCA GGTCCTACTC CCCCCGGAGT
TTTGAGGATT GCGGAGGCGG CTATACCCCG GACTGCAGCT CCAATGAGAA CCTCACCTCC
AGCGAGGAGG ACTTCTCCTC TGGCCAGTCC AGCCGCGTGT CCCCAAGCCC CACCACCTAC
CGCATGTTCC GGGACAAAAG CCGCTCTCCC TCGCAGAACT CGCAACAGTC CTTCGACAGC
AGCAGTCCCC CCACGCCGCA GTGCCATAAG CGGCACCGGC ACTGCCCGGT TGTCGTGTCC
GAGGCCACCA TCGTGGGCGT CCGCAAGACC GGGCAGATCT GGCCCAACGA TGGCGAGGGC
GCCTTCCATG GAGACGCAGA TGGCTCGTTC GGAACACCAC CTGGATACGG CTGCGCTGCA
GACCGGGCAG AGGAGCAGCG CCGGCACCAA GATGGGCTGC CCTACATTGA TGACTCGCCC
TCCTCATCGC CCCACCTCAG CAGCAAGGGC AGGGGCAGCC GGGATGCGCT GGTCTCGGGA
GCCCTGGAGT CCACTAAAGC GAGTGAGCTG GACTTGGAAA AGGGCTTGGA GATGAGAAAA
TGGGTCCTGT CGGGAATCCT GGCTAGCGAG GAGACTTACC TGAGCCACCT GGAGGCACTG
CTGCTGCCCA TGAAGCCTTT GAAAGCCGCT GCCACCACCT CTCAGCCGGT GCTGACGAGT
CAGCAGATCG AGACCATCTT CTTCAAAGTG CCTGAGCTCT ACGAGATCCA CAAGGAGTTC
TATGATGGGC TCTTCCCCCG CGTGCAGCAG TGGAGCCACC AGCAGCGGGT GGGCGACCTC
TTCCAGAAGC TGGCCAGCCA GCTGGGTGTG TACCGGGCCT TCGTGGACAA CTACGGAGTT
GCCATGGAAA TGGCTGAGAA GTGCTGTCAG GCCAATGCTC AGTTTGCAGA AATCTCCGAG
AACCTGAGAG CCAGAAGCAA CAAAGATGCC AAGGATCCAA CGACCAAGAA CTCTCTGGAA
ACTCTGCTCT ACAAGCCTGT GGACCGTGTG ACGAGGAGCA CGCTGGTCCT CCATGACTTG
CTGAAGCACA CTCCTGCCAG CCACCCTGAC CACCCCTTGC TGCAGGACGC CCTCCGCATC
TCACAGAACT TCCTGTCCAG CATCAATGAG GAGATCACAC CCCGACGGCA GTCCATGACG
GTGAAGAAGG GAGAGCACCG GCAGCTGCTG AAGGACAGCT TCATGGTGGA GCTGGTGGAG
GGGGCCCGCA AGCTGCGCCA CGTCTTCCTG TTCACCGACC TGCTTCTCTG CACCAAGCTC
AAGAAGCAGA GCGGAGGCAA AACGCAGCAG TATGACTGCA AATGGTACAT TCCGCTCACG
GATCTCAGCT TCCAGATGGT GGATGAACTG GAGGCAGTGC CCAACATCCC CCTGGTGCCC
GATGAGGAGC TGGACGCTTT GAAGATCAAG ATCTCCCAGA TCAAGAATGA CATCCAGAGA
GAGAAGAGGG CGAACAAGGG CAGCAAGGCT ACGGAGAGGC TGAAGAAGAA GCTGTCGGAG
CAGGAGTCAC TGCTGCTGCT TATGTCTCCC AGCATGGCCT TCAGGGTGCA CAGCCGCAAC
GGCAAGAGTT ACACGTTCCT GATCTCCTCT GACTATGAGC GTGCAGAGTG GAGGGAGAAC
ATCCGGGAGC AGCAGAAGAA GTGTTTCAGA AGCTTCTCCC TGACATCCGT GGAGCTGCAG
ATGCTGACCA ACTCGTGTGT GAAACTCCAG ACTGTCCACA GCATTCCGCT GACCATCAAT
AAGGAAGATG ATGAGTCTCC GGGGCTCTAT GGGTTTCTGA ATGTCATCGT CCACTCAGCC
ACTGGATTTA AGCAGAGTTC AAATCTGTAC TGCACCCTGG AGGTGGATTC CTTTGGGTAT
TTTGTGAATA AAGCAAAGAC GCGCGTCTAC AGGGACACAG CTGAGCCAAA CTGGAACGAG
CTGGACCCGC AGGCCCTGCA GGACAGAGAC TGGCAGCGCA CCGTCATCGC CATGAATGGG
ATCGAAGTAA AGCTCTCGGT CAAGTTCAAC AGCAGGGAGT TCAGCTTGAA GAGGATGCCG
TCCCGAAAAC AGACAGGGGT CTTCGGAGTC AAGATTGCTG TGGTCACCAA GAGAGAGAGG
TCCAAGGTGC CCTACATCGT GCGCCAGTGC GTGGAGGAGA TCGAGCGCCG AGGCATGGAG
GAGGTGGGCA TCTACCGCGT GTCCGGTGTG GCCACGGACA TCCAGGCACT GAAGGCAGCC
TTCGACGTCA ATAACAAGGA CGTGTCGGTG ATGATGAGCG AGATGGACGT GAACGCCATC
GCAGGCACGC TGAAGCTGTA CTTCCGTGAG CTGCCCGAGC CCCTCTTCAC TGACGAGTTC
TACCCCAACT TCGCAGAGGG CATCGCTCTT TCAGACCCGG TTGCAAAGGA GAGCTGCATG
CTCAACCTGC TGCTGTCCCT GCCGGAGGCC AACCTGCTCA CCTTCCTTTT CCTTCTGGAC
CACCTGAAAA GGGTGGCAGA GAAGGAGGCA GTCAATAAGA TGTCCCTGCA CAACCTCGCC
ACGGTCTTTG GCCCCACGCT GCTCCGGCCC TCCGAGAAGG AGAGCAAGCT CCCTGCCAAC
CCCAGCCAGC CTATCACCAT GACTGACAGC TGGTCCTTGG AGGTCATGTC CCAGGTCCAG
GTGCTGCTGT ACTTCCTGCA GCTGGAGGCC ATCCCTGCCC CGGACAGCAA GAGACAGAGC
ATCCTGTTCT CCACCGAAGT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy
Proc. Natl. Acad. Sci. U.S.A. 111 (9), 3550-3555 (2014)
Gibbons DL, Pricl S, Posocco P, Laurini E, Fermeglia M, Sun H, Talpaz M, Donato N and Quintas-Cardama A.


book

Single-cell analysis of K562 cells: an imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and protein
Exp. Hematol. 42 (3), 183-191 (2014)
Karimiani EG, Marriage F, Merritt AJ, Burthem J, Byers RJ and Day PJ.


book

Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: study by the Nagasaki CML Study Group
Leuk. Res. 38 (1), 76-83 (2014)
Itonaga H, Tsushima H, Imanishi D, Hata T, Doi Y, Mori S, Sasaki D, Hasegawa H, Matsuo E, Nakashima J, Kato T, Horai M, Taguchi M, Matsuo M, Taniguchi H, Makiyama J, Sato S, Horio K, Ando K, Moriwaki Y, Sawayama Y, Ogawa D, Yamasaki R, Takasaki Y, Imaizumi Y, Taguchi J, Kawaguchi Y, Yoshida S, Joh T, Moriuchi Y, Nonaka H, Soda H, Fukushima T, Nagai K, Kamihira S, Tomonaga M, Yanagihara K and Miyazaki Y.


book

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL
Blood 122 (15), 2622-2629 (2013)
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP and Den Boer ML.


book

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains
Proc. Natl. Acad. Sci. U.S.A. 110 (37), 14924-14929 (2013)
Sha F, Gencer EB, Georgeon S, Koide A, Yasui N, Koide S and Hantschel O.


book

Amplification and sequencing of genomic breakpoints located within the M-bcr region by Vectorette-mediated polymerase chain reaction
Leukemia 6 (5), 481-483 (1992)
Mills KI, Sproul AM, Ogilvie D, Elvin P, Leibowitz D and Burnett AK.


book

Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach
Proc. Natl. Acad. Sci. U.S.A. 88 (24), 11261-11265 (1991)
Uberbacher EC and Mural RJ.


book

The BCR gene encodes a novel serine/threonine kinase activity within a single exon
Cell 67 (3), 459-468 (1991)
Maru Y and Witte ON.


book

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
Cell 66 (1), 161-171 (1991)
Pendergast AM, Muller AJ, Havlik MH, Maru Y and Witte ON.


book

Reconstruction and analysis of human Alu genes
J. Mol. Evol. 32 (2), 105-121 (1991)
Jurka J and Milosavljevic A.


 
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