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RPS17 cDNA ORF clone, Homo sapiens (human)

Gene Symbol RPS17
Entrez Gene ID 6218
Full Name ribosomal protein S17
Synonyms DBA4, RPS17L, RPS17L1, RPS17L2, S17
General protein information
Preferred Names
40S ribosomal protein S17
Names
40S ribosomal protein S17
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q

Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]. lac of sum
Disorder MIM:

180472

Disorder Html: Diamond-Blackfan anemia 4, 612527 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001021 NP_001012 40S ribosomal protein S17



Homo sapiens (human) RPS17 NP_001012.1
Pan troglodytes (chimpanzee) RPS17 XP_525570.2
Macaca mulatta (Rhesus monkey) RPS17L XP_002804971.1
Canis lupus familiaris (dog) RPS17 NP_001003099.1
Bos taurus (cattle) RPS17 NP_001092680.1
Mus musculus (house mouse) Rps17 NP_033118.1
Gallus gallus (chicken) RPS17L NP_989548.1
Danio rerio (zebrafish) zgc:114188 NP_001013473.1
Caenorhabditis elegans rps-17 NP_491795.1
Arabidopsis thaliana (thale cress) AT3G10610 NP_187672.1
Arabidopsis thaliana (thale cress) AT5G04800 NP_001031834.1
Arabidopsis thaliana (thale cress) AT2G04390 NP_178520.1
Arabidopsis thaliana (thale cress) AT2G05220 NP_565320.1
Xenopus (Silurana) tropicalis (western clawed frog) rps17 XP_002938919.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RPS17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23517
NM_001021 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23517
Clone ID Related Accession (Same CDS sequence) NM_001021
Accession Version NM_001021.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 408bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product 40S ribosomal protein S17
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BM017772.1, BC062715.1 and BE905890.1. On Apr 8, 2014 this sequence version replaced gi:71772428. Transcript Variant: This variant (1) encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI085304.1, BC062715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001012.1
CDS117..524
Misc Feature(1)57..59(+)
Misc Feature(2)117..482(+)
Misc Feature(3)453..455(+)
Misc Feature(4)453..455(+)
Misc Feature(5)504..506(+)
Exon (1)1..119
Gene:RPS17
Gene Synonym:
Exon (2)120..271
Gene:RPS17
Gene Synonym:
Exon (3)272..377
Gene:RPS17
Gene Synonym:
Exon (4)378..443
Gene:RPS17
Gene Synonym:
Exon (5)444..575
Gene:RPS17
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001021
Organism Homo sapiens (human)
Definition Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001021

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGGCCGCG TTCGCACCAA AACCGTGAAG AAGGCGGCCC GGGTCATCAT AGAAAAGTAC 
TACACGCGCC TGGGCAACGA CTTCCACACG AACAAGCGCG TGTGCGAGGA GATCGCCATT
ATCCCCAGCA AAAAGCTCCG CAACAAGATA GCAGGTTATG TCACGCATCT GATGAAGCGA
ATTCAGAGAG GCCCAGTAAG AGGTATCTCC ATCAAGCTGC AGGAGGAGGA GAGAGAAAGG
AGAGACAATT ATGTTCCTGA GGTCTCAGCC TTGGATCAGG AGATTATTGA AGTAGATCCT
GACACTAAGG AAATGCTGAA GCTTTTGGAC TTCGGCAGTC TGTCCAACCT TCAGGTCACT
CAGCCTACAG TTGGGATGAA TTTCAAAACG CCTCGGGGAC CTGTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia
Exp. Mol. Med. 46, E88 (2014)
Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Chul Jeong D, Kim J, Kim JR and Park G.


book

Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination
J. Virol. 86 (10), 5697-5707 (2012)
Shukla P, Nguyen HT, Faulk K, Mather K, Torian U, Engle RE and Emerson SU.


book

Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia
Blood 119 (10), 2376-2384 (2012)
Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E and Hamaguchi I.


book

Ribosomal protein gene deletions in Diamond-Blackfan anemia
Blood 118 (26), 6943-6951 (2011)
Farrar JE, Vlachos A, Atsidaftos E, Carlson-Donohoe H, Markello TC, Arceci RJ, Ellis SR, Lipton JM and Bodine DM.


book

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry
Eur. J. Biochem. 239 (1), 144-149 (1996)
Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B and Otto A.


book

Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon
Biochim. Biophys. Acta 1173 (3), 273-282 (1993)
Mundus DA, Bulygin KN, Yamkovoy VI, Malygin AA, Repkova MN, Vratskikh LV, Venijaminova AG, Vladimirov SN and Karpova GG.


book

Diamond-Blackfan Anemia
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Clinton,C. and Gazda,H.T.


book

The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome
Genomics 13 (1), 201-207 (1992)
Feo S, Davies B and Fried M.


book

The transcriptionally active human ribosomal protein S17 gene
Gene 70 (1), 107-116 (1988)
Chen IT and Roufa DJ.


book

Homologous ribosomal proteins in bacteria, yeast, and humans
Proc. Natl. Acad. Sci. U.S.A. 83 (18), 6907-6911 (1986)
Chen,I.T., Dixit,A., Rhoads,D.D. and Roufa,D.J.


 
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