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RPS26 cDNA ORF clone, Homo sapiens (human)

Gene Symbol RPS26
Entrez Gene ID 6231
Full Name ribosomal protein S26
Synonyms DBA10, S26
General protein information
Preferred Names
40S ribosomal protein S26
Names
40S ribosomal protein S26
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

603701

Disorder Html: Diamond-Blackfan anemia 10, 613309 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001029 NP_001020 40S ribosomal protein S26

KEGG
hsa03010 Ribosome
hsa_M00177 Ribosome, eukaryotes
Reactome
R-HSA-1643685 Disease
R-HSA-168254 Influenza Infection
R-HSA-168255 Influenza Life Cycle
R-HSA-5663205 Infectious disease
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-192823 Viral mRNA Translation
R-HSA-392499 Metabolism of proteins
R-HSA-74160 Gene Expression
R-HSA-72737 Cap-dependent Translation Initiation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72613 Eukaryotic Translation Initiation
R-HSA-72649 Translation initiation complex formation
R-HSA-156902 Peptide chain elongation
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-72766 Translation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-927802 Nonsense-Mediated Decay (NMD)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
WikiPathways
WP477 Cytoplasmic Ribosomal Proteins


Homo sapiens (human) RPS26 NP_001020.2
Pan troglodytes (chimpanzee) RPS26 NP_001239518.1
Macaca mulatta (Rhesus monkey) LOC718588 XP_001116473.1
Canis lupus familiaris (dog) RPS26 XP_531628.1
Bos taurus (cattle) RPS26 NP_001015561.1
Mus musculus (house mouse) Rps26 NP_038793.2
Rattus norvegicus (Norway rat) Rps26 NP_037356.1
Rattus norvegicus (Norway rat) LOC100360508 XP_002728047.2
Gallus gallus (chicken) RPS26 XP_003643590.1
Danio rerio (zebrafish) rps26l NP_957036.1
Danio rerio (zebrafish) rps26 NP_956319.1
Drosophila melanogaster (fruit fly) RpS26 NP_001260537.1
Caenorhabditis elegans rps-26 NP_493571.1
Arabidopsis thaliana (thale cress) AT3G56340 NP_191193.1
Arabidopsis thaliana (thale cress) AT2G40510 NP_181583.1
Arabidopsis thaliana (thale cress) AT2G40590 NP_181591.1
Xenopus (Silurana) tropicalis (western clawed frog) rps26 NP_001005121.1

Component

ID Name Evidence
GO:0005622 intracellular IEA
GO:0005829 cytosol EXP
GO:0005829 cytosol TAS
GO:0015935 small ribosomal subunit IDA
GO:0022627 cytosolic small ribosomal subunit IDA

Function

ID Name Evidence
GO:0003729 mRNA binding IDA
GO:0003735 structural constituent of ribosome IEA
GO:0005515 protein binding IPI

Process

ID Name Evidence
GO:0006412 translation IC
GO:0006412 translation TAS
GO:0006414 translational elongation EXP
GO:0006415 translational termination TAS
GO:0010467 gene expression TAS
GO:0016032 viral reproduction TAS
GO:0019058 viral infectious cycle TAS
GO:0019083 viral transcription TAS
GO:0031018 endocrine pancreas development TAS
GO:0033119 negative regulation of RNA splicing IDA
GO:0044267 cellular protein metabolic process TAS

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RPS26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPS26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18062
NM_001029 Homo sapiens ribosomal protein S26 (RPS26), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18062
Accession Version NM_001029.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 348bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product 40S ribosomal protein S26
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AV681946.1 and BC002604.1. This sequence is a reference standard in the RefSeqGene project. On Aug 1, 2005 this sequence version replaced gi:15011935. Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM553510.1, CD174788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
ATGACAAAGA AAAGAAGGAA CAATGGTCGT GCCAAAAAGG GCCGCGGCCA CGTGCAGCCT 
ATTCGCTGCA CTAACTGTGC CCGATGCGTG CCCAAGGACA AGGCCATTAA GAAATTCGTC
ATTCGAAACA TAGTGGAGGC CGCAGCAGTC AGGGACATTT CTGAAGCGAG CGTCTTCGAT
GCCTATGTGC TTCCCAAGCT GTATGTGAAG CTACATTACT GTGTGAGTTG TGCAATTCAC
AGCAAAGTAG TCAGGAATCG ATCTCGTGAA GCCCGCAAGG ACCGAACACC CCCACCCCGA
TTTAGACCTG CGGGTGCTGC CCCACGTCCC CCACCAAAGC CCATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001020.2
CDS266..613
Misc Feature(1)1..1(+)
Misc Feature(2)215..217(+)
Misc Feature(3)240..240(+)
Misc Feature(4)266..568(+)
Misc Feature(5)551..553(+)
Exon (1)1..268
Gene:RPS26
Gene Synonym:
Exon (2)269..446
Gene:RPS26
Gene Synonym:
Exon (3)447..577
Gene:RPS26
Gene Synonym:
Exon (4)578..682
Gene:RPS26
Gene Synonym:
Translation
Position Chain Variation Link
33 33 c, t dbSNP:546375031
46 46 c, t dbSNP:571418292
57 57 g, t dbSNP:78108003
90 90 a, c dbSNP:542957299
154 154 a, c dbSNP:184400854
169 169 c, t dbSNP:542581614
173 173 c, t dbSNP:555702040
218 218 a, g dbSNP:751621986
223 223 c, t dbSNP:761817603
229 229 c, t dbSNP:573962436
231 231 a, g dbSNP:188808121
232 232 a, g dbSNP:755967083
233 233 a, c, t dbSNP:372794158
235 235 c, g, t dbSNP:17118262
236 236 c, t dbSNP:533292716
237 237 a, c, g dbSNP:771610688
239 239 a, c, t dbSNP:200831849
240 240 c, t dbSNP:545183198
241 241 c, t dbSNP:373484606
242 242 -, tg dbSNP:756909869
242 242 c, t dbSNP:372979323
244 244 -, tcctg dbSNP:778467133
244 244 c, g, t dbSNP:1131017
246 246 c, t dbSNP:377330741
250 250 g, t dbSNP:767770653
251 251 a, g dbSNP:370403104
254 254 a, c, t dbSNP:760630234
256 256 a, t dbSNP:753627670
257 257 a, g, t dbSNP:372708429
259 259 c, t dbSNP:752360531
260 260 c, t dbSNP:757892672
261 261 c, t dbSNP:777209157
262 262 c, t dbSNP:746529217
263 263 a, g dbSNP:181174349
265 265 a, g dbSNP:370598918
266 266 a, g, t dbSNP:143951267
283 283 a, g dbSNP:758884021
296 296 -, g dbSNP:786200892
298 298 c, t dbSNP:778137058
304 304 a, g dbSNP:367838997
305 305 c, g dbSNP:758387701
307 307 c, t dbSNP:771196681
308 308 c, t dbSNP:554573812
310 310 c, t dbSNP:745988736
325 325 a, t dbSNP:368838700
328 328 a, t dbSNP:148167449
329 329 c, g dbSNP:762701251
337 337 c, t dbSNP:768509214
341 341 c, t dbSNP:146651856
343 343 -, tg dbSNP:140419130
346 346 c, t dbSNP:773982358
347 347 c, g dbSNP:142032466
348 348 a, g dbSNP:767205458
349 349 a, c dbSNP:749861594
358 358 c, t dbSNP:760255764
359 359 a, g dbSNP:765640589
362 362 a, g dbSNP:267607023
364 364 c, t dbSNP:753296520
385 385 c, t dbSNP:758822687
386 386 a, c dbSNP:778224908
397 397 a, c dbSNP:751975827
409 409 a, t dbSNP:150715896
412 412 a, t dbSNP:781496094
433 433 g, t dbSNP:745910777
437 437 a, g dbSNP:769953745
448 448 c, g, t dbSNP:370175828
460 460 c, t dbSNP:770710873
472 472 c, g dbSNP:776240183
484 484 c, g dbSNP:150229551
496 496 g, t dbSNP:138813880
524 524 a, c, t dbSNP:148942765
531 531 a, g dbSNP:764673368
535 535 a, g dbSNP:139056836
539 539 c, g dbSNP:762075522
540 540 a, g dbSNP:767978509
544 544 a, g dbSNP:144028746
553 553 a, g dbSNP:373816816
556 556 c, t dbSNP:766621663
559 559 a, g dbSNP:753868018
563 563 c, t dbSNP:755101044
576 576 c, t dbSNP:778791702
577 577 a, g dbSNP:145976784
580 580 a, t dbSNP:554297156
581 581 g, t dbSNP:759607404
590 590 c, t dbSNP:765416321
592 592 a, t dbSNP:56696262
593 593 a, c dbSNP:758315355
597 597 c, t dbSNP:777591468
605 605 c, t dbSNP:751376747
618 618 c, t dbSNP:757155320
619 619 c, t dbSNP:368387432
622 622 -, g dbSNP:766378126
625 625 c, t dbSNP:200207596
627 627 -, a dbSNP:774445353
632 632 a, c dbSNP:769580279
641 641 a, c dbSNP:371184218
646 646 a, t dbSNP:748782268
656 656 a, g dbSNP:772585919
661 661 a, t dbSNP:773642003

Target ORF information:

RefSeq Version NM_001029
Organism Homo sapiens (human)
Definition Homo sapiens ribosomal protein S26 (RPS26), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001029

ORF Insert Sequence:

1
61
121
181
241
301
ATGACAAAGA AAAGAAGGAA CAATGGTCGT GCCAAAAAGG GCCGCGGCCA CGTGCAGCCT 
ATTCGCTGCA CTAACTGTGC CCGATGCGTG CCCAAGGACA AGGCCATTAA GAAATTCGTC
ATTCGAAACA TAGTGGAGGC CGCAGCAGTC AGGGACATTT CTGAAGCGAG CGTCTTCGAT
GCCTATGTGC TTCCCAAGCT GTATGTGAAG CTACATTACT GTGTGAGTTG TGCAATTCAC
AGCAAAGTAG TCAGGAATCG ATCTCGTGAA GCCCGCAAGG ACCGAACACC CCCACCCCGA
TTTAGACCTG CGGGTGCTGC CCCACGTCCC CCACCAAAGC CCATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population
J. Invest. Dermatol. 133 (2), 403-410 (2013)
Tang XF, Zhang Z, Hu DY, Xu AE, Zhou HS, Sun LD, Gao M, Gao TW, Gao XH, Chen HD, Xie HF, Tu CX, Hao F, Wu RN, Zhang FR, Liang L, Pu XM, Zhang JZ, Han JW, Pan GP, Wu JQ, Li K, Su MW, Du WD, Zhang WJ, Liu JJ, Xiang LH, Yang S, Zhou YW and Zhang XJ.


book

High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay
Haematologica 97 (12), 1813-1817 (2012)
Quarello P, Garelli E, Brusco A, Carando A, Mancini C, Pappi P, Vinti L, Svahn J, Dianzani I and Ramenghi U.


book

Ribosomal protein gene deletions in Diamond-Blackfan anemia
Blood 118 (26), 6943-6951 (2011)
Farrar JE, Vlachos A, Atsidaftos E, Carlson-Donohoe H, Markello TC, Arceci RJ, Ellis SR, Lipton JM and Bodine DM.


book

Can mutations in the ribosomal protein S26 (RPS26) gene lead to Klippel-Feil syndrome in Diamond-Blackfan anemia patients? An update from the Czech Diamond-Blackfan Anemia registry
Blood Cells Mol. Dis. 46 (4), 300-301 (2011)
Cmejla,R., Ludikova,B., Sukova,M., Blatny,J. and Pospisilova,D.


book

Genome-wide association analysis identifies three psoriasis susceptibility loci
Nat. Genet. 42 (11), 1000-1004 (2010)
Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B, Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mrowietz U, Lim HW, Voorhees JJ, Abecasis GR, Weichenthal M, Franke A, Rahman P, Gladman DD and Elder JT.


book

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry
Eur. J. Biochem. 239 (1), 144-149 (1996)
Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B and Otto A.


book

[Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]
Bioorg. Khim. 21 (11), 838-844 (1995)
Filipenko,M.L., Mishin,V.P., Suturina,Iu.A., Muravlev,A.I., Kopantsev,E.A., Karpova,G.G. and Mertvetsov,N.P.


book

[Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]
Bioorg. Khim. 20 (6), 644-649 (1994)
Filipenko,M.L., Vladimirov,S.N., Muravlev,A.I., Karpova,G.G. and Mertvetsov,N.P.


book

S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues
Nucleic Acids Res. 21 (6), 1498 (1993)
Vincent S, Marty L and Fort P.


book

Diamond-Blackfan Anemia
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Clinton,C. and Gazda,H.T.


 
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