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SAA1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SAA1
Entrez Gene ID 6288
Full Name serum amyloid A1
Synonyms PIG4, SAA, SAA2, TP53I4
General protein information
Preferred Names
serum amyloid A-1 protein
Names
serum amyloid A-1 protein
serum amyloid A protein
tumor protein p53 inducible protein 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.1

Summary This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]. lac of sum
Disorder MIM:

104750


mRNA and Protein(s)

mRNA Protein Name
NM_199161 NP_954630 serum amyloid A-1 protein preproprotein
NM_000331 NP_000322 serum amyloid A-1 protein preproprotein
NM_001178006 NP_001171477 serum amyloid A-1 protein preproprotein



Homo sapiens (human) SAA1 NP_000322.2
Pan troglodytes (chimpanzee) SAA1 XP_003951896.1
Macaca mulatta (Rhesus monkey) SAA1 XP_001086366.1
Macaca mulatta (Rhesus monkey) LOC694944 XP_001086477.1
Canis lupus familiaris (dog) LOC100684663 XP_003432981.1
Canis lupus familiaris (dog) LOC102155886 XP_005633785.1
Canis lupus familiaris (dog) LOC476879 XP_534081.1
Bos taurus (cattle) SAA3 NP_851359.2
Bos taurus (cattle) SAA2 NP_001068728.1
Bos taurus (cattle) M-SAA3.2 NP_001229502.1
Mus musculus (house mouse) Saa1 NP_033143.1
Mus musculus (house mouse) Saa2 NP_035444.1
Danio rerio (zebrafish) saa NP_001005599.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SAA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SAA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20486
NM_199161 Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486
NM_000331 Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20486
NM_001178006 Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_000331 , NM_001178006 , NM_199161
Accession Version NM_199161.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107948.7, BC007022.1 and BC105796.1. On May 6, 2010 this sequence version replaced gi:133930780. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG568487.1, BG566935.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_954630.1
CDS41..409
Misc Feature(1)101..406(+)
Exon (1)1..36
Gene:SAA1
Gene Synonym:
Exon (2)37..131
Gene:SAA1
Gene Synonym:
Exon (3)132..270
Gene:SAA1
Gene Synonym:
Exon (4)271..531
Gene:SAA1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_199161
Organism Homo sapiens (human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_199161

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_000331 , NM_001178006 , NM_199161
Accession Version NM_000331.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107948.7 and BG565078.1. This sequence is a reference standard in the RefSeqGene project. On May 6, 2010 this sequence version replaced gi:133930781. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG567754.1, BG563257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000322.2
CDS188..556
Misc Feature(1)152..154(+)
Misc Feature(2)248..553(+)
Exon (1)1..183
Gene:SAA1
Gene Synonym:
Exon (2)184..278
Gene:SAA1
Gene Synonym:
Exon (3)279..417
Gene:SAA1
Gene Synonym:
Exon (4)418..678
Gene:SAA1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000331
Organism Homo sapiens (human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000331

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20486
Clone ID Related Accession (Same CDS sequence) NM_000331 , NM_001178006 , NM_199161
Accession Version NM_001178006.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product serum amyloid A-1 protein preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107948.7 and BC105796.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105796.1, BG566837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001171477.1
CDS102..470
Misc Feature(1)66..68(+)
Misc Feature(2)162..467(+)
Exon (1)1..36
Gene:SAA1
Gene Synonym:
Exon (2)37..97
Gene:SAA1
Gene Synonym:
Exon (3)98..192
Gene:SAA1
Gene Synonym:
Exon (4)193..331
Gene:SAA1
Gene Synonym:
Exon (5)332..592
Gene:SAA1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001178006
Organism Homo sapiens (human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001178006

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGCTTC TCACGGGCCT GGTTTTCTGC TCCTTGGTCC TGGGTGTCAG CAGCCGAAGC 
TTCTTTTCGT TCCTTGGCGA GGCTTTTGAT GGGGCTCGGG ACATGTGGAG AGCCTACTCT
GACATGAGAG AAGCCAATTA CATCGGCTCA GACAAATACT TCCATGCTCG GGGGAACTAT
GATGCTGCCA AAAGGGGACC TGGGGGTGCC TGGGCTGCAG AAGTGATCAG CGATGCCAGA
GAGAATATCC AGAGATTCTT TGGCCATGGT GCGGAGGACT CGCTGGCTGA TCAGGCTGCC
AATGAATGGG GCAGGAGTGG CAAAGACCCC AATCACTTCC GACCTGCTGG CCTGCCTGAG
AAATACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Effect of amino acid variations in the central region of human serum amyloid A on the amyloidogenic properties
Biochem. Biophys. Res. Commun. 444 (1), 92-97 (2014)
Takase H, Tanaka M, Miyagawa S, Yamada T and Mukai T.


book

Serum amyloid A: expression throughout human ovarian folliculogenesis and levels in follicular fluid of women undergoing controlled ovarian stimulation
J. Clin. Endocrinol. Metab. 98 (12), 4970-4978 (2013)
Urieli-Shoval S, Finci-Yeheskel Z, Eldar I, Linke RP, Levin M, Prus D and Haimov-Kochman R.


book

Interaction of serum amyloid A with human cystatin C--assessment of amino acid residues crucial for hCC-SAA formation (part II)
J. Mol. Recognit. 26 (9), 415-425 (2013)
Spodzieja M, Rafalik M, Szymanska A, Kolodziejczyk AS and Czaplewska P.


book

Rs12218 In SAA1 gene was associated with serum lipid levels
Lipids Health Dis 12, 116 (2013)
Xu XL, Sun XT, Pang L, Huang G, Huang J, Shi M and Wang YQ.


book

Human serum amyloid A protein. Complete amino acid sequence of a new variant
Biochem. J. 282 (PT 2), 615-620 (1992)
Beach CM, De Beer MC, Sipe JD, Loose LD and De Beer FC.


book

The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells
Scand. J. Immunol. 34 (4), 471-482 (1991)
Betts JC, Edbrooke MR, Thakker RV and Woo P.


book

Serum amyloid A, an acute phase protein, inhibits platelet activation
J. Lab. Clin. Med. 116 (2), 180-186 (1990)
Zimlichman S, Danon A, Nathan I, Mozes G and Shainkin-Kestenbaum R.


book

Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells
J. Biol. Chem. 262 (32), 15790-15795 (1987)
Woo P, Sipe J, Dinarello CA and Colten HR.


book

Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA
Biochemistry 24 (12), 2931-2936 (1985)
Sipe,J.D., Colten,H.R., Goldberger,G., Edge,M.D., Tack,B.F., Cohen,A.S. and Whitehead,A.S.


book

The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues)
Biochem. Biophys. Res. Commun. 69 (1), 19-25 (1976)
Sletten,K., Husby,G. and Natvig,J.B.


 
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