||ORF Nucleotide Sequence (Length: 300bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||C-C motif chemokine 2 precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG530064.1 and BC009716.1.
This sequence is a reference standard in the RefSeqGene project.
On Nov 29, 2004 this sequence version replaced gi:22538812.
Summary: This gene is one of several cytokine genes clustered on
the q-arm of chromosome 17. Chemokines are a superfamily of
secreted proteins involved in immunoregulatory and inflammatory
processes. The superfamily is divided into four subfamilies based
on the arrangement of N-terminal cysteine residues of the mature
peptide. This chemokine is a member of the CC subfamily which is
characterized by two adjacent cysteine residues. This cytokine
displays chemotactic activity for monocytes and basophils but not
for neutrophils or eosinophils. It has been implicated in the
pathogenesis of diseases characterized by monocytic infiltrates,
like psoriasis, rheumatoid arthritis and atherosclerosis. It binds
to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC009716.1, CD522574.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.