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CCL2 chemokine (C-C motif) ligand 2 [Homo sapiens (human)]

Gene Symbol CCL2
Entrez Gene ID 6347
Full Name chemokine (C-C motif) ligand 2
Synonyms GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
General protein information
Preferred Names
C-C motif chemokine 2
Names
C-C motif chemokine 2
small-inducible cytokine A2
monocyte secretory protein JE
monocyte chemotactic protein 1
monocyte chemoattractant protein 1
monocyte chemoattractant protein-1
monocyte chemotactic and activating factor
small inducible cytokine subfamily A (Cys-Cys), member 2
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2-q12

Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]. lac of sum
Disorder MIM:

158105

Disorder Html: {HIV-1, resistance to}, 609423 (3); {Spina bifida, susceptibility





The following CCL2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18411 NM_002982 Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18411
Accession Version NM_002982.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu18411D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG530064.1 and BC009716.1. This sequence is a reference standard in the RefSeqGene project. On Nov 29, 2004 this sequence version replaced gi:22538812. Summary: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009716.1, CD522574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002973.1
CDS74..373
Misc Feature(1)143..145(+)
Misc Feature(2)152..154(+)
Misc Feature(3)152..154(+)
Misc Feature(4)152..154(+)
Misc Feature(5)164..166(+)
Misc Feature(6)173..346(+)
Misc Feature(7)173..346(+)
Misc Feature(8)179..346(+)
Misc Feature(9)179..298(+)
Misc Feature(10)179..295(+)
Misc Feature(11)179..214(+)
Misc Feature(12)179..181(+)
Misc Feature(13)185..346(+)
Misc Feature(14)191..289(+)
Misc Feature(15)194..196(+)
Misc Feature(16)197..199(+)
Misc Feature(17)212..214(+)
Misc Feature(18)230..337(+)
Misc Feature(19)245..250(+)
Misc Feature(20)245..247(+)
Misc Feature(21)254..256(+)
Misc Feature(22)275..283(+)
Misc Feature(23)287..289(+)
Misc Feature(24)314..316(+)
Misc Feature(25)338..340(+)
Exon (1)1..149
Gene:CCL2
Gene Synonym:
Exon (2)150..267
Gene:CCL2
Gene Synonym:
Exon (3)268..749
Gene:CCL2
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:756777436
6 6 a, c dbSNP:767198628
9 9 a, g dbSNP:750066113
19 19 a, g dbSNP:755877280
22 22 g, t dbSNP:779871993
24 24 a, g dbSNP:749627296
37 37 a, c dbSNP:369439824
39 39 a, g dbSNP:779422035
47 47 a, g dbSNP:748665636
52 52 a, g dbSNP:557966833
53 53 g, t dbSNP:773321785
56 56 c, g, t dbSNP:141271352
58 58 c, g dbSNP:776841122
59 59 a, g dbSNP:762750838
62 62 -, t dbSNP:771283629
62 62 c, g dbSNP:763852250
64 64 c, g, t dbSNP:774337603
68 68 a, t dbSNP:370016526
71 71 a, g dbSNP:749900916
84 84 c, t dbSNP:755719349
94 94 c, t dbSNP:766065319
95 95 c, t dbSNP:753449998
97 97 a, g dbSNP:755360396
110 110 a, g dbSNP:144450837
111 111 c, t dbSNP:748658453
116 116 c, g dbSNP:758954928
120 120 c, g dbSNP:778276611
128 128 -, c dbSNP:774898999
129 129 c, t dbSNP:374418259
130 130 c, g dbSNP:747023179
155 155 a, g dbSNP:146604396
166 166 a, g dbSNP:746076530
178 178 c, t dbSNP:4586
188 188 a, g dbSNP:780351792
193 193 c, t dbSNP:371187910
195 195 a, g dbSNP:145056785
196 196 -, at dbSNP:772588061
217 217 c, t dbSNP:138768575
218 218 a, c, g dbSNP:760761240
219 219 c, t dbSNP:148937652
226 226 c, t dbSNP:759111149
233 233 a, g dbSNP:764759504
236 236 a, t dbSNP:752406037
238 238 c, t dbSNP:143644230
278 278 a, g dbSNP:148285031
284 284 a, g dbSNP:190996557
298 298 c, t dbSNP:750956211
303 303 a, g dbSNP:756136784
304 304 a, c dbSNP:766548953
308 308 a, g dbSNP:754083053
313 313 a, g dbSNP:755304641
325 325 a, g dbSNP:779304120
332 332 a, g dbSNP:746763384
333 333 a, t dbSNP:757082330
335 335 a, g dbSNP:780976524
339 339 a, c dbSNP:745882578
348 348 a, g dbSNP:563897168
355 355 c, t dbSNP:769152199
363 363 c, t dbSNP:199565451
364 364 a, g dbSNP:368861512
375 375 -, cact dbSNP:760747031
383 383 c, t dbSNP:376859120
385 385 a, g dbSNP:768257187
388 388 a, g dbSNP:773995779
390 390 a, c dbSNP:762024084
391 391 c, g dbSNP:763076758
407 407 a, t dbSNP:373290550
411 411 -, t dbSNP:764415777
415 415 g, t dbSNP:181021073
417 417 c, g dbSNP:761285800
419 419 c, t dbSNP:766347726
424 424 c, t dbSNP:753924842
438 438 c, t dbSNP:13900
476 476 c, t dbSNP:549055140
545 545 g, t dbSNP:186178409
597 597 a, c dbSNP:191032356
598 598 c, t dbSNP:2215182
642 642 a, c dbSNP:528328195
655 655 a, t dbSNP:75284178
656 656 -, t dbSNP:770114076
657 657 a, t dbSNP:75433364
657 657 -, t dbSNP:536851983
662 662 c, t dbSNP:532809366
665 665 a, g dbSNP:777894448
722 722 c, t dbSNP:552570373

Target ORF information:

RefSeq Version NM_002982
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002982

ORF Insert Sequence:

1
61
121
181
241
ATGAAAGTCT CTGCCGCCCT TCTGTGCCTG CTGCTCATAG CAGCCACCTT CATTCCCCAA 
GGGCTCGCTC AGCCAGATGC AATCAATGCC CCAGTCACCT GCTGTTATAA CTTCACCAAT
AGGAAGATCT CAGTGCAGAG GCTCGCGAGC TATAGAAGAA TCACCAGCAG CAAGTGTCCC
AAAGAAGCTG TGATCTTCAA GACCATTGTG GCCAAGGAGA TCTGTGCTGA CCCCAAGCAG
AAGTGGGTTC AGGATTCCAT GGACCACCTG GACAAGCAAA CCCAAACTCC GAAGACTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.