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CCL4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCL4
Entrez Gene ID 6351
Full Name chemokine (C-C motif) ligand 4
Synonyms ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4
General protein information
Preferred Names
C-C motif chemokine 4
Names
C-C motif chemokine 4
PAT 744
SIS-gamma
MIP-1-beta(1-69)
secreted protein G-26
T-cell activation protein 2
G-26 T-lymphocyte-secreted protein
lymphocyte activation gene 1 protein
macrophage inflammatory protein 1-beta
small inducible cytokine A4 (homologous to mouse Mip-1b)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]. lac of sum
Disorder MIM:

182284


mRNA and Protein(s)

mRNA Protein Name
NM_002984 NP_002975 C-C motif chemokine 4 precursor



Homo sapiens (human) CCL4 NP_002975.1
Pan troglodytes (chimpanzee) CCL4 XP_001173914.1
Macaca mulatta (Rhesus monkey) CCL4L1 NP_001028045.1
Macaca mulatta (Rhesus monkey) LOC100430627 XP_002800427.1
Macaca mulatta (Rhesus monkey) LOC100426632 XP_002800713.1
Macaca mulatta (Rhesus monkey) LOC100423861 XP_002800704.1
Canis lupus familiaris (dog) CCL4 NP_001005250.1
Bos taurus (cattle) CCL4 NP_001068615.1
Mus musculus (house mouse) Ccl4 NP_038680.1
Rattus norvegicus (Norway rat) Ccl4 NP_446310.1
Gallus gallus (chicken) CCL4 NP_990051.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60429 NM_002984 Homo sapiens chemokine (C-C motif) ligand 4 (CCL4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu60429
Clone ID Related Accession (Same CDS sequence) NM_002984
Accession Version NM_002984.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 279bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 4 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY766446.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2015 this sequence version replaced gi:90704850. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY766446.1, CD521723.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGAAGCTCT GCGTGACTGT CCTGTCTCTC CTCATGCTAG TAGCTGCCTT CTGCTCTCCA 
GCGCTCTCAG CACCAATGGG CTCAGACCCT CCCACCGCCT GCTGCTTTTC TTACACCGCG
AGGAAGCTTC CTCGCAACTT TGTGGTAGAT TACTATGAGA CCAGCAGCCT CTGCTCCCAG
CCAGCTGTGG TATTCCAAAC CAAAAGAAGC AAGCAAGTCT GTGCTGATCC CAGTGAATCC
TGGGTCCAGG AGTACGTGTA TGACCTGGAA CTGAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002975.1
CDS80..358
Misc Feature(1)53..55(+)
Misc Feature(2)152..154(+)
Misc Feature(3)179..349(+)
Misc Feature(4)179..349(+)
Misc Feature(5)185..349(+)
Misc Feature(6)185..301(+)
Misc Feature(7)185..298(+)
Misc Feature(8)185..220(+)
Misc Feature(9)191..349(+)
Misc Feature(10)197..292(+)
Misc Feature(11)236..340(+)
Misc Feature(12)248..253(+)
Misc Feature(13)278..286(+)
Misc Feature(14)650..655(+)
Exon (1)1..155
Gene:CCL4
Gene Synonym:
Exon (2)156..270
Gene:CCL4
Gene Synonym:
Exon (3)271..667
Gene:CCL4
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002984
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 4 (CCL4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002984

ORF Insert Sequence:

1
61
121
181
241
ATGAAGCTCT GCGTGACTGT CCTGTCTCTC CTCATGCTAG TAGCTGCCTT CTGCTCTCCA 
GCGCTCTCAG CACCAATGGG CTCAGACCCT CCCACCGCCT GCTGCTTTTC TTACACCGCG
AGGAAGCTTC CTCGCAACTT TGTGGTAGAT TACTATGAGA CCAGCAGCCT CTGCTCCCAG
CCAGCTGTGG TATTCCAAAC CAAAAGAAGC AAGCAAGTCT GTGCTGATCC CAGTGAATCC
TGGGTCCAGG AGTACGTGTA TGACCTGGAA CTGAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Effects of beta-hydroxy-beta-methylbutyrate free acid and cold water immersion on expression of CR3 and MIP-1beta following resistance exercise
Am. J. Physiol. Regul. Integr. Comp. Physiol. 306 (7), R483-R489 (2014)
Gonzalez AM, Fragala MS, Jajtner AR, Townsend JR, Wells AJ, Beyer KS, Boone CH, Pruna GJ, Mangine GT, Bohner JD, Fukuda DH, Stout JR and Hoffman JR.


book

Increased expression of CCL4/MIP-1beta in CD8+ cells and CD4+ cells in sarcoidosis
Int J Immunopathol Pharmacol 27 (2), 185-193 (2014)
Barczyk A, Pierzchala E, Caramori G and Sozanska E.


book

Dynamics of chemokine, cytokine, and growth factor serum levels in BRAF-mutant melanoma patients during BRAF inhibitor treatment
J. Immunol. 192 (5), 2505-2513 (2014)
Wilmott JS, Haydu LE, Menzies AM, Lum T, Hyman J, Thompson JF, Hersey P, Kefford RF, Scolyer RA and Long GV.


book

27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes
Toxicol. Appl. Pharmacol. 274 (3), 462-470 (2014)
Kim SM, Kim BY, Lee SA, Eo SK, Yun Y, Kim CD and Kim K.


book

Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical pathway
Clin. Exp. Immunol. 175 (1), 92-103 (2014)
Barrios CS, Castillo L, Zhi H, Giam CZ and Beilke MA.


book

The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization
J. Biol. Chem. 266 (26), 17531-17536 (1991)
Napolitano M, Modi WS, Cevario SJ, Gnarra JR, Seuanez HN and Leonard WJ.


book

Cloning and expression of a lymphocyte activation gene (LAG-1)
Mol. Immunol. 27 (11), 1091-1102 (1990)
Baixeras E, Roman-Roman S, Jitsukawa S, Genevee C, Mechiche S, Viegas-Pequignot E, Hercend T and Triebel F.


book

Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q
Nucleic Acids Res. 18 (11), 3261-3270 (1990)
Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U and Kelly K.


book

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes
J. Immunol. 142 (2), 679-687 (1989)
Brown KD, Zurawski SM, Mosmann TR and Zurawski G.


book

Identification, cloning, and characterization of an immune activation gene
Proc. Natl. Acad. Sci. U.S.A. 85 (24), 9704-9708 (1988)
Lipes MA, Napolitano M, Jeang KT, Chang NT and Leonard WJ.


 
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