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CCL13 chemokine (C-C motif) ligand 13 [Homo sapiens (human)]

Gene Symbol CCL13
Entrez Gene ID 6357
Full Name chemokine (C-C motif) ligand 13
Synonyms CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1
General protein information
Preferred Names
C-C motif chemokine 13
Names
C-C motif chemokine 13
CK-beta-10
new CC chemokine 1
small-inducible cytokine A13
monocyte chemotactic protein 4
monocyte chemoattractant protein 4
small inducible cytokine subfamily A (Cys-Cys), member 13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2

Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

601391

Disorder Html:





The following CCL13 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL13 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu29848 NM_005408 Homo sapiens chemokine (C-C motif) ligand 13 (CCL13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu29848
Accession Version NM_005408.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 297bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 13 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U59808.1. On Aug 29, 2002 this sequence version replaced gi:4885586. Summary: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: U59808.1, BG620880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_005399.1
CDS76..372
Misc Feature(1)49..51(+)
Misc Feature(2)145..147(+)
Misc Feature(3)151..153(+)
Misc Feature(4)151..153(+)
Misc Feature(5)154..156(+)
Misc Feature(6)154..156(+)
Misc Feature(7)163..165(+)
Misc Feature(8)175..342(+)
Misc Feature(9)175..342(+)
Misc Feature(10)181..342(+)
Misc Feature(11)181..297(+)
Misc Feature(12)181..294(+)
Misc Feature(13)181..216(+)
Misc Feature(14)187..342(+)
Misc Feature(15)193..288(+)
Misc Feature(16)232..336(+)
Misc Feature(17)244..249(+)
Misc Feature(18)274..282(+)
Exon (1)1..151
Gene:CCL13
Gene Synonym:
Exon (2)152..266
Gene:CCL13
Gene Synonym:
Exon (3)267..851
Gene:CCL13
Gene Synonym:
Translation
Position Chain Variation Link
6 6 a, g dbSNP:560145924
8 8 c, t dbSNP:571556948
27 27 a, g dbSNP:376966664
36 36 a, c dbSNP:749572938
45 45 a, g dbSNP:768879474
47 47 c, t dbSNP:772925066
49 49 c, t dbSNP:370367733
50 50 a, g dbSNP:746851613
65 65 c, t dbSNP:199632606
69 69 c, t dbSNP:373864188
84 84 a, c, t dbSNP:776678465
88 88 g, t dbSNP:3136677
93 93 a, g dbSNP:775266633
99 99 a, g dbSNP:762633152
102 102 c, t dbSNP:140451239
109 109 c, t dbSNP:752823625
110 110 a, t dbSNP:751824838
112 112 a, c dbSNP:367957184
114 114 a, g dbSNP:145325564
116 116 c, g dbSNP:751009010
120 120 a, g dbSNP:756174315
142 142 g, t dbSNP:780053174
157 157 c, t dbSNP:762083323
161 161 a, g dbSNP:34566308
162 162 c, t dbSNP:532498797
163 163 a, g dbSNP:749453524
165 165 -, c dbSNP:755783195
165 165 c, g dbSNP:369147614
180 180 c, t dbSNP:373567305
181 181 a, t dbSNP:755099124
183 183 c, t dbSNP:778969931
192 192 c, t dbSNP:149285419
196 196 -, aag dbSNP:777345964
198 198 a, g dbSNP:753027787
200 200 a, c dbSNP:756986624
202 202 a, g dbSNP:780979455
206 206 c, t dbSNP:745658417
211 211 c, t dbSNP:377585122
236 236 c, g dbSNP:780192818
240 240 a, c dbSNP:748780538
245 245 c, g dbSNP:768350035
248 248 a, g dbSNP:773864741
249 249 c, t dbSNP:761472042
251 251 c, t dbSNP:564838885
265 265 a, g dbSNP:773586979
278 278 a, c dbSNP:759975138
282 282 a, g dbSNP:143510106
284 284 a, g dbSNP:367613739
291 291 g, t dbSNP:762960516
292 292 a, t dbSNP:758137997
296 296 a, g dbSNP:534660128
314 314 a, t dbSNP:137918947
318 318 c, g dbSNP:755965057
320 320 c, t dbSNP:766223344
326 326 a, g dbSNP:577924843
330 330 c, t dbSNP:749651505
339 339 a, c dbSNP:754905287
345 345 a, c dbSNP:778740838
346 346 c, t dbSNP:183253878
347 347 a, g dbSNP:187454526
351 351 a, c, g dbSNP:757885510
352 352 a, g, t dbSNP:372653174
353 353 c, t dbSNP:776910644
362 362 -, tgaagact dbSNP:750754428
370 370 g, t dbSNP:573925061
374 374 c, t dbSNP:779852870
378 378 a, g dbSNP:775907825
380 380 c, t dbSNP:763086648
381 381 a, g dbSNP:764140711
382 382 c, t dbSNP:774589882
383 383 c, g dbSNP:762063628
400 400 g, t dbSNP:377174787
403 403 a, g dbSNP:753641013
407 407 a, c, t dbSNP:751463485
408 408 a, g dbSNP:370593553
415 415 a, g dbSNP:752642615
422 422 c, t dbSNP:757912599
424 424 a, g, t dbSNP:777206868
442 442 c, t dbSNP:542740740
458 458 c, t dbSNP:771895967
460 460 c, t dbSNP:191543093
491 491 c, t dbSNP:528475517
515 515 a, c dbSNP:557754223
516 516 c, t dbSNP:754953835
518 518 c, t dbSNP:777705769
519 519 a, g dbSNP:749455119
529 529 -, t dbSNP:774831219
577 577 g, t dbSNP:139142355
598 598 a, g dbSNP:149499630
618 618 -, t dbSNP:373186520
665 665 g, t dbSNP:533284969
669 669 a, c dbSNP:75348820
672 672 c, t dbSNP:144148427
673 673 a, g, t dbSNP:535679541
685 685 g, t dbSNP:746116756
693 693 a, g dbSNP:182653739
730 730 a, g dbSNP:772526231
745 745 c, t dbSNP:186581102
751 751 a, g dbSNP:776037462
797 797 c, t dbSNP:192522491
800 800 c, t dbSNP:534280819
806 806 g, t dbSNP:185659231

Target ORF information:

RefSeq Version NM_005408
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 13 (CCL13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005408

ORF Insert Sequence:

1
61
121
181
241
ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.