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CCL18 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCL18
Entrez Gene ID 6362
Full Name chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Synonyms AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
General protein information
Preferred Names
C-C motif chemokine 18
Names
C-C motif chemokine 18
CC chemokine PARC
CC chemokine ligand 18
chemokine (C-C), dendritic
dendritic cell chemokine 1
small inducible cytokine A18
small-inducible cytokine A18
macrophage inflammatory protein 4
pulmonary and activation-regulated chemokine
alternative macrophage activation-associated CC chemokine 1
small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

603757

Disorder Html:





The following CCL18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu16454 NM_002988 Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00

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**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu16454
Accession Version NM_002988.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 270bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 18 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243829.3, BC096124.3 and BU617136.1. On Sep 19, 2014 this sequence version replaced gi:22547150. Summary: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: Y13710.1, AB000221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
ATGAAGGGCC TTGCAGCTGC CCTCCTTGTC CTCGTCTGCA CCATGGCCCT CTGCTCCTGT 
GCACAAGTTG GTACCAACAA AGAGCTCTGC TGCCTCGTCT ATACCTCCTG GCAGATTCCA
CAAAAGTTCA TAGTTGACTA TTCTGAAACC AGCCCCCAGT GCCCCAAGCC AGGTGTCATC
CTCCTAACCA AGAGAGGCCG GCAGATCTGT GCTGACCCCA ATAAGAAGTG GGTCCAGAAA
TACATCAGCG ACCTGAAGCT GAATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_002979.1
CDS72..341
Misc Feature(1)45..47(+)
Misc Feature(2)159..329(+)
Misc Feature(3)159..329(+)
Misc Feature(4)165..329(+)
Misc Feature(5)165..281(+)
Misc Feature(6)165..278(+)
Misc Feature(7)165..200(+)
Misc Feature(8)171..329(+)
Misc Feature(9)177..272(+)
Misc Feature(10)216..320(+)
Misc Feature(11)228..233(+)
Misc Feature(12)258..266(+)
Exon (1)1..138
Gene:CCL18
Gene Synonym:
Exon (2)139..250
Gene:CCL18
Gene Synonym:
Exon (3)251..781
Gene:CCL18
Gene Synonym:
Translation
Position Chain Variation Link
21 21 a, g dbSNP:774926948
28 28 c, t dbSNP:558912524
38 38 c, t dbSNP:780645213
45 45 a, t dbSNP:749382552
55 55 g, t dbSNP:768815599
62 62 a, g dbSNP:774457234
63 63 c, t dbSNP:748378437
74 74 c, g dbSNP:770672987
77 77 -, ggcct dbSNP:775421030
77 77 a, c, g dbSNP:558031922
78 78 g, t dbSNP:759527592
80 80 a, c dbSNP:765174314
84 84 a, g dbSNP:374115816
87 87 c, g dbSNP:762485548
90 90 a, g dbSNP:73290772
91 91 c, t dbSNP:377682562
101 101 c, g dbSNP:369599857
104 104 c, t dbSNP:756926531
105 105 a, g dbSNP:767827152
127 127 c, g, t dbSNP:750809251
134 134 a, c dbSNP:544452516
139 139 c, t dbSNP:766826506
142 142 g, t dbSNP:754434896
163 163 g, t dbSNP:377474798
164 164 a, c dbSNP:755538594
167 167 c, t dbSNP:778919095
168 168 a, g dbSNP:138061691
175 175 a, c dbSNP:752837570
181 181 a, g dbSNP:758345356
197 197 a, g, t dbSNP:201008180
205 205 c, t dbSNP:753211629
208 208 a, c dbSNP:779797706
215 215 c, t dbSNP:749277496
225 225 c, t dbSNP:768648633
227 227 c, t dbSNP:370369732
230 230 -, gtgcc dbSNP:768687637
233 233 c, t dbSNP:774087303
238 238 a, t dbSNP:761414533
240 240 a, c dbSNP:771433218
243 243 g, t dbSNP:773046025
250 250 a, t dbSNP:760372568
257 257 a, t dbSNP:763341723
260 260 c, t dbSNP:764229182
261 261 -, aa dbSNP:761777261
265 265 a, c, g, t dbSNP:751647990
267 267 a, g dbSNP:750559440
270 270 c, t dbSNP:540060026
271 271 a, g dbSNP:778538949
282 282 a, g dbSNP:748182428
285 285 a, g dbSNP:746913136
291 291 a, g dbSNP:149506889
292 292 a, g dbSNP:150076657
293 293 g, t dbSNP:770526900
299 299 a, g dbSNP:200043307
308 308 c, g dbSNP:148220878
320 320 c, g, t dbSNP:770237802
321 321 a, g dbSNP:374733570
344 344 a, g dbSNP:764586647
345 345 g, t dbSNP:774796470
354 354 c, g dbSNP:761900736
357 357 c, t dbSNP:369185675
358 358 a, g dbSNP:750696839
359 359 a, g dbSNP:756284141
362 362 a, g dbSNP:765136779
365 365 c, t dbSNP:752448782
380 380 a, g dbSNP:758200108
383 383 c, t dbSNP:371605708
386 386 g, t dbSNP:746895944
387 387 a, t dbSNP:138678712
435 435 c, t dbSNP:14304
521 521 c, t dbSNP:113206976
531 531 c, t dbSNP:142865584
580 580 c, t dbSNP:774493976
592 592 c, t dbSNP:766555
619 619 c, t dbSNP:766556
622 622 a, t dbSNP:545265101
627 627 a, g dbSNP:535323825
637 637 a, c dbSNP:531113192
645 645 c, g dbSNP:544527136
678 678 c, t dbSNP:561030794
707 707 c, g, t dbSNP:374302530
748 748 c, t dbSNP:546720003
769 769 a, g, t dbSNP:111899690

Target ORF information:

RefSeq Version NM_002988
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002988

ORF Insert Sequence:

1
61
121
181
241
ATGAAGGGCC TTGCAGCTGC CCTCCTTGTC CTCGTCTGCA CCATGGCCCT CTGCTCCTGT 
GCACAAGTTG GTACCAACAA AGAGCTCTGC TGCCTCGTCT ATACCTCCTG GCAGATTCCA
CAAAAGTTCA TAGTTGACTA TTCTGAAACC AGCCCCCAGT GCCCCAAGCC AGGTGTCATC
CTCCTAACCA AGAGAGGCCG GCAGATCTGT GCTGACCCCA ATAAGAAGTG GGTCCAGAAA
TACATCAGCG ACCTGAAGCT GAATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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