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CCL18 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCL18
Entrez Gene ID 6362
Full Name chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Synonyms AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
General protein information
Preferred Names
C-C motif chemokine 18
Names
C-C motif chemokine 18
CC chemokine PARC
CC chemokine ligand 18
chemokine (C-C), dendritic
dendritic cell chemokine 1
small inducible cytokine A18
small-inducible cytokine A18
macrophage inflammatory protein 4
pulmonary and activation-regulated chemokine
alternative macrophage activation-associated CC chemokine 1
small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

603757


mRNA and Protein(s)

mRNA Protein Name
NM_002988 NP_002979 C-C motif chemokine 18 precursor



Homo sapiens (human) CCL18 NP_002979.1
Pan troglodytes (chimpanzee) CCL18 XP_523615.1
Macaca mulatta (Rhesus monkey) CCL18 NP_001028025.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCL18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu16454
NM_002988 Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16454
Clone ID Related Accession (Same CDS sequence) NM_002988
Accession Version NM_002988.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 270bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 18 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243829.3, BC096124.3 and BU617136.1. On Sep 19, 2014 this sequence version replaced gi:22547150. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: Y13710.1, AB000221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
ATGAAGGGCC TTGCAGCTGC CCTCCTTGTC CTCGTCTGCA CCATGGCCCT CTGCTCCTGT 
GCACAAGTTG GTACCAACAA AGAGCTCTGC TGCCTCGTCT ATACCTCCTG GCAGATTCCA
CAAAAGTTCA TAGTTGACTA TTCTGAAACC AGCCCCCAGT GCCCCAAGCC AGGTGTCATC
CTCCTAACCA AGAGAGGCCG GCAGATCTGT GCTGACCCCA ATAAGAAGTG GGTCCAGAAA
TACATCAGCG ACCTGAAGCT GAATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002979.1
CDS72..341
Misc Feature(1)45..47(+)
Misc Feature(2)159..329(+)
Misc Feature(3)159..329(+)
Misc Feature(4)165..329(+)
Misc Feature(5)165..281(+)
Misc Feature(6)165..278(+)
Misc Feature(7)165..200(+)
Misc Feature(8)171..329(+)
Misc Feature(9)177..272(+)
Misc Feature(10)216..320(+)
Misc Feature(11)228..233(+)
Misc Feature(12)258..266(+)
Exon (1)1..138
Gene:CCL18
Gene Synonym:
Exon (2)139..250
Gene:CCL18
Gene Synonym:
Exon (3)251..781
Gene:CCL18
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002988
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002988

ORF Insert Sequence:

1
61
121
181
241
ATGAAGGGCC TTGCAGCTGC CCTCCTTGTC CTCGTCTGCA CCATGGCCCT CTGCTCCTGT 
GCACAAGTTG GTACCAACAA AGAGCTCTGC TGCCTCGTCT ATACCTCCTG GCAGATTCCA
CAAAAGTTCA TAGTTGACTA TTCTGAAACC AGCCCCCAGT GCCCCAAGCC AGGTGTCATC
CTCCTAACCA AGAGAGGCCG GCAGATCTGT GCTGACCCCA ATAAGAAGTG GGTCCAGAAA
TACATCAGCG ACCTGAAGCT GAATGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Expression of chemokine ligand 18 in stage IA low-grade endometrial cancer
Anticancer Res. 34 (10), 5331-5336 (2014)
Sakane R, Tsubamoto H, Sakata K, Inoue K, Ogino M, Shibahara H, Hao H and Hirota S.


book

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
Cancer Cell 25 (5), 605-620 (2014)
Su S, Liu Q, Chen J, Chen J, Chen F, He C, Huang D, Wu W, Lin L, Huang W, Zhang J, Cui X, Zheng F, Li H, Yao H, Su F and Song E.


book

Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis
J. Cell. Biochem. 115 (3), 596-603 (2014)
Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Song EW and Chen JQ.


book

CC chemokine ligand 18 and IGF-binding protein 6 as potential serum biomarkers for prostate cancer
Tohoku J. Exp. Med. 233 (1), 25-31 (2014)
Xu Y, Zhang L, Sun SK and Zhang X.


book

Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection
BMC Urol 13, 42 (2013)
Miyake M, Ross S, Lawton A, Chang M, Dai Y, Mengual L, Alcaraz A, Giacoia EG, Goodison S and Rosser CJ.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern
J. Immunol. 160 (3), 1411-1418 (1998)
Kodelja V, Muller C, Politz O, Hakij N, Orfanos CE and Goerdt S.


book

A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes
J. Immunol. 159 (3), 1140-1149 (1997)
Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O and Nomiyama H.


book

A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
Nature 387 (6634), 713-717 (1997)
Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB and Figdor CG.


book

The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases
J. Leukoc. Biol. 61 (5), 545-550 (1997)
Wells TN and Peitsch MC.


 
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