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CXCL6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CXCL6
Entrez Gene ID 6372
Full Name chemokine (C-X-C motif) ligand 6
Synonyms CKA-3, GCP-2, GCP2, SCYB6
General protein information
Preferred Names
C-X-C motif chemokine 6
Names
C-X-C motif chemokine 6
chemokine alpha 3
small-inducible cytokine B6
granulocyte chemotactic protein 2
Small inducible cytokine subfamily B (Cys-X-Cys), member b
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q13.3

Summary lac of sum
Disorder MIM:

138965


mRNA and Protein(s)

mRNA Protein Name
NM_002993 NP_002984 C-X-C motif chemokine 6 precursor



Homo sapiens (human) CXCL6 NP_002984.1
Pan troglodytes (chimpanzee) CXCL6 XP_001156255.1
Macaca mulatta (Rhesus monkey) CXCL6 XP_001103136.1
Mus musculus (house mouse) Cxcl5 NP_033167.2
Rattus norvegicus (Norway rat) Cxcl5 NP_071550.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CXCL6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu14703
NM_002993 Homo sapiens chemokine (C-X-C motif) ligand 6 (CXCL6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu14703
Clone ID Related Accession (Same CDS sequence) NM_002993
Accession Version NM_002993.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 345bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-X-C motif chemokine 6 precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP204144.1, AC108029.3 and U81234.1. On Jul 31, 2008 this sequence version replaced gi:52851409. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U81234.1, BC013744.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002984.1
CDS196..540
Misc Feature(1)94..96(+)
Misc Feature(2)331..516(+)
Misc Feature(3)331..498(+)
Misc Feature(4)331..339(+)
Misc Feature(5)334..516(+)
Misc Feature(6)334..462(+)
Misc Feature(7)337..348(+)
Misc Feature(8)343..384(+)
Misc Feature(9)349..465(+)
Misc Feature(10)370..510(+)
Misc Feature(11)376..462(+)
Misc Feature(12)382..516(+)
Misc Feature(13)409..417(+)
Misc Feature(14)409..417(+)
Misc Feature(15)448..456(+)
Exon (1)1..304
Gene:CXCL6
Gene Synonym:
Exon (2)305..437
Gene:CXCL6
Gene Synonym:
Exon (3)438..521
Gene:CXCL6
Gene Synonym:
Exon (4)522..1659
Gene:CXCL6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002993
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 6 (CXCL6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002993

ORF Insert Sequence:

1
61
121
181
241
301
ATGAGCCTCC CGTCCAGCCG CGCGGCCCGT GTCCCGGGTC CTTCGGGCTC CTTGTGCGCG 
CTGCTCGCGC TGCTGCTCCT GCTGACGCCG CCGGGGCCCC TCGCCAGCGC TGGTCCTGTC
TCTGCTGTGC TGACAGAGCT GCGTTGCACT TGTTTACGCG TTACGCTGAG AGTAAACCCC
AAAACGATTG GTAAACTGCA GGTGTTCCCC GCAGGCCCGC AGTGCTCCAA GGTGGAAGTG
GTAGCCTCCC TGAAGAACGG GAAGCAAGTT TGTCTGGACC CGGAAGCCCC TTTTCTAAAG
AAAGTCATCC AGAAAATTTT GGACAGTGGA AACAAGAAAA ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester
Hum. Reprod. 28 (9), 2350-2362 (2013)
Zhang H, Hou L, Li CM and Zhang WY.


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature 491 (7422), 119-124 (2012)
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.


book

Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model
Cardiovasc. Res. 95 (4), 495-506 (2012)
Kim SW, Lee DW, Yu LH, Zhang HZ, Kim CE, Kim JM, Park TH, Cha KS, Seo SY, Roh MS, Lee KC, Jung JS and Kim MH.


book

Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis
Cancer Lett. 302 (1), 54-62 (2011)
Verbeke H, Struyf S, Berghmans N, Van Coillie E, Opdenakker G, Uyttenhove C, Van Snick J and Van Damme J.


book

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'
PLoS Genet. 6 (7), E1001016 (2010)
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I and Chenevix-Trench G.


book

Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids
Genomics 47 (1), 136-139 (1998)
Modi WS and Chen ZQ.


book

Cloning and characterization of the human granulocyte chemotactic protein-2 gene
J. Immunol. 158 (11), 5257-5266 (1997)
Rovai LE, Herschman HR and Smith JB.


book

Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs
Eur. J. Biochem. 243 (3), 762-769 (1997)
Froyen G, Proost P, Ronsse I, Mitera T, Haelens A, Wuyts A, Opdenakker G, Van Damme J and Billiau A.


book

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines
Biochemistry 32 (38), 10170-10177 (1993)
Proost P, Wuyts A, Conings R, Lenaerts JP, Billiau A, Opdenakker G and Van Damme J.


book

Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8
J. Immunol. 150 (3), 1000-1010 (1993)
Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A and Van Damme J.


 
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