||ORF Nucleotide Sequence (Length: 843bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC007840.2, BF796275.1 and
This sequence is a reference standard in the RefSeqGene project.
On Sep 28, 2006 this sequence version replaced gi:9257241.
Summary: Complex II of the respiratory chain, which is specifically
involved in the oxidation of succinate, carries electrons from FADH
to CoQ. The complex is composed of four nuclear-encoded subunits
and is localized in the mitochondrial inner membrane. The
iron-sulfur subunit is highly conserved and contains three
cysteine-rich clusters which may comprise the iron-sulfur centers
of the enzyme. Sporadic and familial mutations in this gene result
in paragangliomas and pheochromocytoma, and support a link between
mitochondrial dysfunction and tumorigenesis. [provided by RefSeq,
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
gene product(s) localized to mito. :: PMID: 2302193; reported by
Transcript exon combination :: BC007840.2, U17248.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.