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SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Homo sapiens (human)]

Gene Symbol SDHB
Entrez Gene ID 6390
Full Name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP
General protein information
Preferred Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
iron-sulfur subunit of complex II
NP_002991.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.1-p35

Summary Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

185470

Disorder Html: Paraganglioma, familial chromaffin, 4, 115310 (3); Pheochromocytoma,





The following SDHB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SDHB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18105 NM_003000 Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18105
Accession Version NM_003000.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 843bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC007840.2, BF796275.1 and BU554163.1. This sequence is a reference standard in the RefSeqGene project. On Sep 28, 2006 this sequence version replaced gi:9257241. Summary: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 2302193; reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC007840.2, U17248.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCGGCGG TGGTCGCCCT CTCCTTGAGG CGCCGGTTGC CGGCCACAAC CCTTGGCGGA 
GCCTGCCTGC AGGCCTCCCG AGGAGCCCAG ACAGCTGCAG CCACAGCTCC CCGTATCAAG
AAATTTGCCA TCTATCGATG GGACCCAGAC AAGGCTGGAG ACAAACCTCA TATGCAGACT
TATGAAGTTG ACCTTAATAA ATGTGGCCCC ATGGTATTGG ATGCTTTAAT CAAGATTAAG
AATGAAGTTG ACTCTACTTT GACCTTCCGA AGATCATGCA GAGAAGGCAT CTGTGGCTCT
TGTGCAATGA ACATCAATGG AGGCAACACT CTAGCTTGCA CCCGAAGGAT TGACACCAAC
CTCAATAAGG TCTCAAAAAT CTACCCTCTT CCACACATGT ATGTGATAAA GGATCTTGTT
CCCGATTTGA GCAACTTCTA TGCACAGTAC AAATCCATTG AGCCTTATTT GAAGAAGAAG
GATGAATCTC AGGAAGGCAA GCAGCAGTAT CTGCAGTCCA TAGAAGAGCG TGAGAAACTG
GACGGGCTCT ACGAGTGCAT TCTCTGTGCC TGCTGTAGCA CCAGCTGCCC CAGCTACTGG
TGGAACGGAG ACAAATATCT GGGGCCTGCA GTTCTTATGC AGGCCTATCG CTGGATGATT
GACTCCAGAG ATGACTTCAC AGAGGAGCGC CTGGCCAAGC TGCAGGACCC ATTCTCTCTA
TACCGCTGCC ACACCATCAT GAACTGCACA AGGACCTGTC CTAAGGGTCT GAATCCAGGG
AAAGCTATTG CAGAGATCAA GAAAATGATG GCAACCTATA AGGAGAAGAA AGCTTCAGTT
TAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002991.2
CDS152..994
Misc Feature(1)122..124(+)
Misc Feature(2)164..964(+)
Misc Feature(3)317..>478(+)
Misc Feature(4)416..454(+)
Misc Feature(5)428..454(+)
Misc Feature(6)704..925(+)
Exon (1)1..223
Gene:SDHB
Gene Synonym:
Exon (2)224..351
Gene:SDHB
Gene Synonym:
Exon (3)352..437
Gene:SDHB
Gene Synonym:
Exon (4)438..574
Gene:SDHB
Gene Synonym:
Exon (5)575..691
Gene:SDHB
Gene Synonym:
Exon (6)692..793
Gene:SDHB
Gene Synonym:
Exon (7)794..916
Gene:SDHB
Gene Synonym:
Exon (8)917..1153
Gene:SDHB
Gene Synonym:
Translation
Position Chain Variation Link
13 13 g, t dbSNP:114522228
20 20 a, g dbSNP:201399804
24 24 c, g dbSNP:752179224
35 35 -, g dbSNP:34633163
37 37 c, t dbSNP:764337079
42 42 a, c dbSNP:200295549
46 46 c, g dbSNP:572586759
47 47 c, g dbSNP:536563013
56 56 c, t dbSNP:377524880
73 73 c, t dbSNP:201830436
78 78 a, g dbSNP:201016499
84 84 a, t dbSNP:200229285
107 107 a, g dbSNP:202039513
114 114 c, t dbSNP:201233054
115 115 c, g, t dbSNP:143031690
118 118 g, t dbSNP:371505816
120 120 g, t dbSNP:756888012
130 130 a, c, g dbSNP:781774867
135 135 c, t dbSNP:755418430
137 137 a, g dbSNP:201837175
139 139 -, g dbSNP:780678661
144 144 c, g dbSNP:376889033
146 146 a, g dbSNP:2295056
147 147 c, t dbSNP:200890535
156 156 c, t dbSNP:199948437
158 158 a, g dbSNP:765429934
159 159 c, g dbSNP:11203289
162 162 g, t dbSNP:776656866
163 163 a, g dbSNP:768683606
165 165 g, t dbSNP:760565241
169 169 a, c, g dbSNP:2746462
170 170 c, t dbSNP:745664191
171 171 c, t dbSNP:778776844
172 172 c, g, t dbSNP:147815442
173 173 c, t dbSNP:777447369
174 174 c, g, t dbSNP:199848267
175 175 c, t dbSNP:148738139
177 177 a, t dbSNP:786203800
182 182 c, t dbSNP:200868378
183 183 a, g dbSNP:111430410
184 184 c, t dbSNP:146399542
185 185 a, c dbSNP:761996626
187 187 c, g dbSNP:754024341
190 190 a, g dbSNP:201745731
192 192 c, t dbSNP:764089231
193 193 a, g dbSNP:760753435
196 196 c, t dbSNP:764875162
198 198 c, g dbSNP:775350144
201 201 a, c, t dbSNP:138979875
202 202 a, c dbSNP:550555402
205 205 g, t dbSNP:759446168
212 212 a, g dbSNP:774266782
216 216 a, c, g dbSNP:141230910
217 217 c, t dbSNP:772853861
224 224 a, c, g dbSNP:768101924
226 226 c, t dbSNP:200329668
230 230 c, g, t dbSNP:74315369
231 231 a, g dbSNP:373976827
239 239 -, c dbSNP:747198089
241 241 a, g dbSNP:749662497
248 248 a, g dbSNP:777898500
260 260 c, t dbSNP:761180960
263 263 -, cc dbSNP:398123690
263 263 c, t dbSNP:202119350
264 264 a, g dbSNP:143058777
274 274 a, g dbSNP:137877851
275 275 c, t dbSNP:767667150
281 281 a, g dbSNP:200418115
287 287 c, g, t dbSNP:74315370
288 288 a, g dbSNP:772551056
294 294 a, t dbSNP:202101384
300 300 a, g dbSNP:201219456
309 309 a, g dbSNP:34916635
315 315 a, g dbSNP:764843485
317 317 -, cctca dbSNP:786202100
321 321 a, g dbSNP:35962811
329 329 a, g dbSNP:34599281
333 333 a, g dbSNP:768171765
334 334 c, t dbSNP:760169139
342 342 a, c dbSNP:200131173
344 344 c, t dbSNP:786202185
354 354 a, g dbSNP:587782904
359 359 a, c dbSNP:200890320
368 368 c, t dbSNP:763734164
373 373 a, t dbSNP:199678117
376 376 c, t dbSNP:201762207
384 384 a, g dbSNP:774960237
385 385 a, g dbSNP:776971836
386 386 a, t dbSNP:771524558
387 387 c, t dbSNP:572028124
399 399 g, t dbSNP:763547482
411 411 c, t dbSNP:727504457
415 415 c, g dbSNP:41310416
419 419 c, g, t dbSNP:74315366
420 420 a, g dbSNP:570278423
428 428 c, t dbSNP:727503415
437 437 a, g dbSNP:587782243
438 438 a, g dbSNP:778952116
439 439 c, t dbSNP:757123577
450 450 c, t dbSNP:121917755
451 451 c, t dbSNP:11541235
453 453 a, g dbSNP:74315371
455 455 a, g dbSNP:777578399
458 458 a, g dbSNP:140178341
462 462 a, gg dbSNP:786201316
470 470 a, g dbSNP:752361543
474 474 a, g dbSNP:767062764
490 490 c, t dbSNP:754582722
493 493 c, t dbSNP:528599830
494 494 c, t dbSNP:751000085
495 495 a, g, t dbSNP:200973284
498 498 c, g dbSNP:777234785
503 503 a, g, t dbSNP:200021702
507 507 a, c, t dbSNP:11541234
513 513 c, t dbSNP:775925040
525 525 a, c dbSNP:786203506
527 527 a, g dbSNP:202095022
530 530 a, c dbSNP:201372280
531 531 g, t dbSNP:786201095
534 534 a, g dbSNP:772158627
537 537 c, g dbSNP:587781735
540 540 c, t dbSNP:746011241
546 546 a, c, g dbSNP:74315372
549 549 c, t dbSNP:553392349
550 550 g, t dbSNP:201403014
551 551 c, t dbSNP:771004483
552 552 a, g dbSNP:200893429
554 554 a, g dbSNP:201585157
563 563 g, t dbSNP:786203529
566 566 c, t dbSNP:397516834
567 567 g, t dbSNP:777629820
569 569 g, t dbSNP:267607032
574 574 a, c, t dbSNP:150542357
576 576 a, t dbSNP:759709073
591 591 a, g dbSNP:774568101
598 598 g, t dbSNP:200353146
606 606 c, t dbSNP:200414835
612 612 a, g dbSNP:545307760
614 614 c, t dbSNP:763008243
619 619 c, t dbSNP:199718947
638 638 c, t dbSNP:33927012
639 639 c, t dbSNP:769687734
642 642 a, g dbSNP:747984404
662 662 c, t dbSNP:780870337
667 667 a, g dbSNP:138937650
670 670 c, t dbSNP:768454654
672 672 c, t dbSNP:200301019
674 674 c, g dbSNP:202203339
675 675 a, g dbSNP:746643960
678 678 a, g dbSNP:201082445
680 680 c, t dbSNP:149091125
681 681 a, g dbSNP:150437793
691 691 a, g dbSNP:528442805
692 692 a, g dbSNP:201385062
694 694 c, t dbSNP:199809975
695 695 a, g dbSNP:201928318
703 703 c, t dbSNP:202098600
705 705 a, g dbSNP:786203899
706 706 a, g dbSNP:761890806
715 715 c, t dbSNP:776487215
719 719 a, g dbSNP:199789177
720 720 c, t dbSNP:201900648
725 725 c, t dbSNP:786202732
726 726 a, c, g dbSNP:397516835
728 728 a, g dbSNP:760438782
732 732 c, g dbSNP:200535030
733 733 c, t dbSNP:775450654
741 741 c, g dbSNP:74315367
751 751 a, g, t dbSNP:397516836
757 757 c, t dbSNP:199653121
758 758 -, ggagacaaat dbSNP:587782617
758 758 a, g dbSNP:201517260
765 765 a, g dbSNP:774090318
785 785 c, t dbSNP:17354040
787 787 c, t dbSNP:778439194
788 788 a, t dbSNP:770622939
789 789 c, t dbSNP:202014362
792 792 a, c dbSNP:781590955
794 794 a, g dbSNP:772798766
800 800 c, g, t dbSNP:200245469
801 801 a, g dbSNP:747518441
821 821 a, g dbSNP:780477085
834 834 -, ag dbSNP:762812025
839 839 c, t dbSNP:138996609
840 840 a, g, t dbSNP:587782604
846 846 c, t dbSNP:746224555
847 847 c, t dbSNP:779143585
851 851 c, t dbSNP:201728852
852 852 a, t dbSNP:786202913
853 853 a, g dbSNP:370397369
860 860 c, g, t dbSNP:186768244
867 867 -, ctct dbSNP:587781266
867 867 c, g, t dbSNP:201098090
871 871 a, g dbSNP:759446340
875 875 c, t dbSNP:786203251
876 876 a, g dbSNP:74315368
881 881 c, t dbSNP:766038910
887 887 a, g dbSNP:146800605
890 890 a, g dbSNP:200896502
904 904 a, g dbSNP:201094649
906 906 c, t dbSNP:769359897
909 909 a, g dbSNP:786201085
912 912 -, c dbSNP:34309090
916 916 c, g dbSNP:761295633
920 920 c, g dbSNP:761350633
922 922 c, g dbSNP:199714034
936 936 c, t dbSNP:776093267
937 937 c, t dbSNP:768118230
949 949 c, t dbSNP:760042733
951 951 a, g dbSNP:774666954
952 952 g, t dbSNP:771388711
956 956 a, g dbSNP:749612417
965 965 a, g dbSNP:545681543
969 969 a, g dbSNP:773523792
988 988 a, g dbSNP:770120161
1004 1004 c, t dbSNP:748333077
1011 1011 c, t dbSNP:780627760
1012 1012 a, g dbSNP:201588339
1017 1017 a, t dbSNP:755040707
1019 1019 a, g dbSNP:746978845
1023 1023 c, t dbSNP:200504954
1024 1024 c, t dbSNP:199701267
1032 1032 a, g dbSNP:750150938
1033 1033 a, g dbSNP:764987243
1041 1041 a, t dbSNP:756922080
1096 1096 a, g dbSNP:201155896
1100 1100 a, g dbSNP:200366300
1104 1104 c, t dbSNP:201950006
1113 1113 -, t dbSNP:35417465
1123 1123 a, g dbSNP:191249882
1127 1127 c, t dbSNP:111686611
1137 1137 c, t dbSNP:201524374
1144 1144 a, g dbSNP:200374366
1146 1146 a, c dbSNP:202218720
1153 1153 -, a dbSNP:532333715
1153 1153 a, g dbSNP:75557632

Target ORF information:

RefSeq Version NM_003000
Organism Homo sapiens (human)
Definition Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003000

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCGGCGG TGGTCGCCCT CTCCTTGAGG CGCCGGTTGC CGGCCACAAC CCTTGGCGGA 
GCCTGCCTGC AGGCCTCCCG AGGAGCCCAG ACAGCTGCAG CCACAGCTCC CCGTATCAAG
AAATTTGCCA TCTATCGATG GGACCCAGAC AAGGCTGGAG ACAAACCTCA TATGCAGACT
TATGAAGTTG ACCTTAATAA ATGTGGCCCC ATGGTATTGG ATGCTTTAAT CAAGATTAAG
AATGAAGTTG ACTCTACTTT GACCTTCCGA AGATCATGCA GAGAAGGCAT CTGTGGCTCT
TGTGCAATGA ACATCAATGG AGGCAACACT CTAGCTTGCA CCCGAAGGAT TGACACCAAC
CTCAATAAGG TCTCAAAAAT CTACCCTCTT CCACACATGT ATGTGATAAA GGATCTTGTT
CCCGATTTGA GCAACTTCTA TGCACAGTAC AAATCCATTG AGCCTTATTT GAAGAAGAAG
GATGAATCTC AGGAAGGCAA GCAGCAGTAT CTGCAGTCCA TAGAAGAGCG TGAGAAACTG
GACGGGCTCT ACGAGTGCAT TCTCTGTGCC TGCTGTAGCA CCAGCTGCCC CAGCTACTGG
TGGAACGGAG ACAAATATCT GGGGCCTGCA GTTCTTATGC AGGCCTATCG CTGGATGATT
GACTCCAGAG ATGACTTCAC AGAGGAGCGC CTGGCCAAGC TGCAGGACCC ATTCTCTCTA
TACCGCTGCC ACACCATCAT GAACTGCACA AGGACCTGTC CTAAGGGTCT GAATCCAGGG
AAAGCTATTG CAGAGATCAA GAAAATGATG GCAACCTATA AGGAGAAGAA AGCTTCAGTT
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.