The following SDHB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SDHB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 843bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC007840.2, BF796275.1 and
This sequence is a reference standard in the RefSeqGene project.
On Sep 28, 2006 this sequence version replaced gi:9257241.
Summary: Complex II of the respiratory chain, which is specifically
involved in the oxidation of succinate, carries electrons from FADH
to CoQ. The complex is composed of four nuclear-encoded subunits
and is localized in the mitochondrial inner membrane. The
iron-sulfur subunit is highly conserved and contains three
cysteine-rich clusters which may comprise the iron-sulfur centers
of the enzyme. Sporadic and familial mutations in this gene result
in paragangliomas and pheochromocytoma, and support a link between
mitochondrial dysfunction and tumorigenesis. [provided by RefSeq,
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
gene product(s) localized to mito. :: PMID: 2302193; reported by
Transcript exon combination :: BC007840.2, U17248.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.