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TMPRSS3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TMPRSS3
Entrez Gene ID 64699
Full Name transmembrane protease, serine 3
Synonyms DFNB10, DFNB8, ECHOS1, TADG12
General protein information
Preferred Names
transmembrane protease serine 3
Names
transmembrane protease serine 3
serine protease TADG-12
tumor-associated differentially-expressed gene 12 protein
NP_001243246.1
NP_076927.1
NP_115780.1
NP_115781.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.3

Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. lac of sum
Disorder MIM:

605511

Disorder Html: Deafness, autosomal recessive 8, childhood onset, 601072 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_032405 NP_115781 transmembrane protease serine 3 isoform 3
NM_032404 NP_115780 transmembrane protease serine 3 isoform 2
NM_001256317 NP_001243246 transmembrane protease serine 3 isoform 4
NM_024022 NP_076927 transmembrane protease serine 3 isoform 1


Homo sapiens (human) TMPRSS3 NP_001243246.1
Pan troglodytes (chimpanzee) TMPRSS3 XP_001137100.3
Macaca mulatta (Rhesus monkey) TMPRSS3 XP_001105841.2
Canis lupus familiaris (dog) TMPRSS3 XP_853682.3
Bos taurus (cattle) TMPRSS3 NP_001179855.1
Mus musculus (house mouse) Tmprss3 NP_001157248.1
Rattus norvegicus (Norway rat) Tmprss3 NP_001101089.1
Gallus gallus (chicken) TMPRSS3 XP_425558.3
Danio rerio (zebrafish) tmprss3a XP_001340422.5
Drosophila melanogaster (fruit fly) CG4613 NP_648707.2
Drosophila melanogaster (fruit fly) CG3355 NP_608848.1
Xenopus (Silurana) tropicalis (western clawed frog) tmprss3 XP_002940514.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TMPRSS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMPRSS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25754 NM_032405 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu27004 NM_032404 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu27241 NM_001256317 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant F, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu26323 NM_024022 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25754
Clone ID Related Accession (Same CDS sequence) NM_032405
Accession Version NM_032405.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1035bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038160.1. Transcript Variant: This variant (D) lacks several 3' exons, but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant A. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038160.1, AF267741.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115781.1
CDS202..1236
Misc Feature(1)1..298(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..>1173(+)
Misc Feature(8)850..>1212(+)
Misc Feature(9)850..852(+)
Misc Feature(10)970..1113(+)
Misc Feature(11)299..406(+)
Misc Feature(12)1153..1154(+)
Misc Feature(13)1154..1359(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1342
Gene:TMPRSS3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_032405
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032405

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27004
Clone ID Related Accession (Same CDS sequence) NM_032404
Accession Version NM_032404.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 984bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA643571.1, AB038159.1, AK172842.1 and AI251446.1. On or before Jan 19, 2012 this sequence version replaced gi:224994255, gi:14602454. Transcript Variant: This variant (C) lacks several 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant A. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_115780.1
CDS281..1264
Misc Feature(1)77..79(+)
Misc Feature(2)281..532(+)
Misc Feature(3)545..1231(+)
Misc Feature(4)548..1240(+)
Misc Feature(5)548..550(+)
Misc Feature(6)668..1102(+)
Misc Feature(7)1082..1165(+)
Exon (1)1..221
Gene:TMPRSS3
Gene Synonym:
Exon (2)222..345
Gene:TMPRSS3
Gene Synonym:
Exon (3)346..471
Gene:TMPRSS3
Gene Synonym:
Exon (4)472..515
Gene:TMPRSS3
Gene Synonym:
Exon (5)516..681
Gene:TMPRSS3
Gene Synonym:
Exon (6)682..851
Gene:TMPRSS3
Gene Synonym:
Exon (7)852..947
Gene:TMPRSS3
Gene Synonym:
Exon (8)948..1093
Gene:TMPRSS3
Gene Synonym:
Exon (9)1094..1246
Gene:TMPRSS3
Gene Synonym:
Exon (10)1247..2139
Gene:TMPRSS3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_032404
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032404

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27241
Clone ID Related Accession (Same CDS sequence) NM_001256317
Accession Version NM_001256317.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1362bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AY358458.1, AK172842.1, AB038159.1 and AI251446.1. Transcript Variant: This variant (F) uses an alternate in-frame splice site in the central coding region, compared to variant A, resulting in an isoform (4) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172842.1, AF201380.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001243246.1
CDS202..1563
Misc Feature(1)346..408(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..1530(+)
Misc Feature(8)847..852(+)
Misc Feature(9)850..1539(+)
Misc Feature(10)850..852(+)
Misc Feature(11)970..1401(+)
Misc Feature(12)1381..1464(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1153
Gene:TMPRSS3
Gene Synonym:
Exon (10)1154..1249
Gene:TMPRSS3
Gene Synonym:
Exon (11)1250..1392
Gene:TMPRSS3
Gene Synonym:
Exon (12)1393..1545
Gene:TMPRSS3
Gene Synonym:
Exon (13)1546..2438
Gene:TMPRSS3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001256317
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant F, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001256317

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26323
Clone ID Related Accession (Same CDS sequence) NM_024022
Accession Version NM_024022.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1365bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AK172842.1 and AI251446.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2009 this sequence version replaced gi:13173470. Transcript Variant: This variant (A) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038157.1, AY633572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_076927.1
CDS202..1566
Misc Feature(1)346..408(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..1533(+)
Misc Feature(8)847..852(+)
Misc Feature(9)850..1542(+)
Misc Feature(10)850..852(+)
Misc Feature(11)970..1404(+)
Misc Feature(12)1384..1467(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1153
Gene:TMPRSS3
Gene Synonym:
Exon (10)1154..1249
Gene:TMPRSS3
Gene Synonym:
Exon (11)1250..1395
Gene:TMPRSS3
Gene Synonym:
Exon (12)1396..1548
Gene:TMPRSS3
Gene Synonym:
Exon (13)1549..2441
Gene:TMPRSS3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_024022
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024022

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetic analysis of TMPRSS3 gene in the Korean population with autosomal recessive nonsyndromic hearing loss
Gene 532 (2), 276-280 (2013)
Lee J, Baek JI, Choi JY, Kim UK, Lee SH and Lee KY.


book

A novel genome-based approach correlates TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation
Gynecol. Oncol. 125 (3), 720-726 (2012)
Guerrero K, Wang Z, Bachvarova M, Gregoire J, Renaud MC, Plante M and Bachvarov D.


book

Molecular analysis of the TMPRSS3 gene in Moroccan families with non-syndromic hearing loss
Biochem. Biophys. Res. Commun. 419 (4), 643-647 (2012)
Charif M, Abidi O, Boulouiz R, Nahili H, Rouba H, Kandil M, Delprat B, Lenaers G and Barakat A.


book

Genotype-phenotype correlation in DFNB8/10 families with TMPRSS3 mutations
J. Assoc. Res. Otolaryngol. 12 (6), 753-766 (2011)
Weegerink NJ, Schraders M, Oostrik J, Huygen PL, Strom TM, Granneman S, Pennings RJ, Venselaar H, Hoefsloot LH, Elting M, Cremers CW, Admiraal RJ, Kremer H and Kunst HP.


book

Characterization of a new full length TMPRSS3 isoform and identification of mutant alleles responsible for nonsyndromic recessive deafness in Newfoundland and Pakistan
BMC Med. Genet. 5, 24 (2004)
Ahmed ZM, Li XC, Powell SD, Riazuddin S, Young TL, Ramzan K, Ahmad Z, Luscombe S, Dhillon K, MacLaren L, Ploplis B, Shotland LI, Ives E, Riazuddin S, Friedman TB, Morell RJ and Wilcox ER.


book

Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness
Nat. Genet. 27 (1), 59-63 (2001)
Scott HS, Kudoh J, Wattenhofer M, Shibuya K, Berry A, Chrast R, Guipponi M, Wang J, Kawasaki K, Asakawa S, Minoshima S, Younus F, Mehdi SQ, Radhakrishna U, Papasavvas MP, Gehrig C, Rossier C, Korostishevsky M, Gal A, Shimizu N, Bonne-Tamir B and Antonarakis SE.


book

Ovarian tumor cells express a novel multi-domain cell surface serine protease
Biochim. Biophys. Acta 1502 (3), 337-350 (2000)
Underwood LJ, Shigemasa K, Tanimoto H, Beard JB, Schneider EN, Wang Y, Parmley TH and O'Brien TJ.


book

A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer
Cancer Res. 60 (10), 2602-2606 (2000)
Wallrapp C, Hahnel S, Muller-Pillasch F, Burghardt B, Iwamura T, Ruthenburger M, Lerch MM, Adler G and Gress TM.


book

Linkage of congenital recessive deafness (gene DFNB10) to chromosome 21q22.3
Am. J. Hum. Genet. 58 (6), 1254-1259 (1996)
Bonne-Tamir B, DeStefano AL, Briggs CE, Adair R, Franklyn B, Weiss S, Korostishevsky M, Frydman M, Baldwin CT and Farrer LA.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


 
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