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TMPRSS3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TMPRSS3
Entrez Gene ID 64699
Full Name transmembrane protease, serine 3
Synonyms DFNB10, DFNB8, ECHOS1, TADG12
General protein information
Preferred Names
transmembrane protease serine 3
Names
transmembrane protease serine 3
serine protease TADG-12
tumor-associated differentially-expressed gene 12 protein
NP_001243246.1
NP_076927.1
NP_115780.1
NP_115781.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.3

Summary This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. lac of sum
Disorder MIM:

605511

Disorder Html: Deafness, autosomal recessive 8, childhood onset, 601072 (3);





The following TMPRSS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMPRSS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25754 NM_032405 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319.00
OHu27004 NM_032404 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199.00
OHu27241 NM_001256317 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant F, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319.00
OHu26323 NM_024022 Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu25754
Accession Version NM_032405.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1035bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038160.1. Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (D) lacks several 3' exons, but includes an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant A. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038160.1, AF267741.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_115781.1
CDS202..1236
Misc Feature(1)1..298(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..>1173(+)
Misc Feature(8)850..>1212(+)
Misc Feature(9)850..852(+)
Misc Feature(10)970..1113(+)
Misc Feature(11)299..406(+)
Misc Feature(12)1153..1154(+)
Misc Feature(13)1154..1359(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1342
Gene:TMPRSS3
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:755944650
4 4 a, g, t dbSNP:56100074
10 10 c, t dbSNP:540503594
11 11 a, g dbSNP:754521287
13 13 a, t dbSNP:753306106
14 14 c, t dbSNP:377532101
15 15 a, g dbSNP:762360884
16 16 g, t dbSNP:752032749
19 19 a, c dbSNP:767574751
20 20 a, c, g dbSNP:147296608
27 27 c, t dbSNP:765305889
28 28 g, t dbSNP:759691958
30 30 a, g dbSNP:191054653
33 33 c, t dbSNP:56347158
37 37 a, g dbSNP:771111101
45 45 a, g dbSNP:746981844
50 50 c, t dbSNP:773269515
51 51 a, g dbSNP:771916158
55 55 a, g dbSNP:200277359
59 59 c, t dbSNP:778659792
60 60 a, c dbSNP:754542420
64 64 a, c dbSNP:748920724
66 66 c, g dbSNP:779582533
69 69 c, t dbSNP:755619879
71 71 a, c, g dbSNP:56369547
79 79 g, t dbSNP:758790604
87 87 a, g dbSNP:752961392
92 92 c, t dbSNP:765518679
93 93 a, g dbSNP:759886263
103 103 a, g dbSNP:375438526
106 106 a, g dbSNP:776962558
114 114 c, t dbSNP:766631539
115 115 a, g dbSNP:371722059
120 120 a, g dbSNP:773287558
123 123 a, g dbSNP:771866484
124 124 a, t dbSNP:557132994
129 129 a, g dbSNP:774066728
136 136 c, g dbSNP:768469011
141 141 c, t dbSNP:749010685
142 142 a, g dbSNP:779671143
148 148 c, t dbSNP:755630225
151 151 a, g dbSNP:371778905
157 157 c, g dbSNP:756454876
159 159 g, t dbSNP:750630070
161 161 g, t dbSNP:538734255
166 166 c, g dbSNP:186244930
167 167 c, g dbSNP:751468633
168 168 a, g dbSNP:73372256
173 173 c, t dbSNP:376404558
174 174 a, g dbSNP:775213790
175 175 a, g dbSNP:769552964
178 178 a, g dbSNP:759150161
180 180 c, t dbSNP:373324024
192 192 a, g dbSNP:770405018
204 204 g, t dbSNP:746461825
208 208 a, g dbSNP:779595310
212 212 a, t dbSNP:769238563
218 218 c, t dbSNP:139865555
219 219 a, g, t dbSNP:200199344
222 222 a, t dbSNP:143981919
226 226 c, g dbSNP:149481350
229 229 a, g dbSNP:781420452
233 233 a, c dbSNP:372629505
234 234 c, t dbSNP:138052370
237 237 c, t dbSNP:764038602
240 240 c, g dbSNP:150765531
242 242 c, t dbSNP:752598801
248 248 a, g, t dbSNP:369418733
251 251 a, c, t dbSNP:766015335
252 252 a, g dbSNP:182209675
253 253 a, c, t dbSNP:372359927
264 264 c, t dbSNP:749880255
266 266 a, g dbSNP:776129573
268 268 a, g dbSNP:770072040
272 272 -, t dbSNP:771977117
284 284 a, c, t dbSNP:137882698
286 286 c, g dbSNP:757448130
302 302 a, t dbSNP:142917173
318 318 g, t dbSNP:747297139
322 322 c, t dbSNP:779277523
324 324 g, t dbSNP:201147366
325 325 c, t dbSNP:758485931
334 334 c, t dbSNP:748158424
335 335 c, t dbSNP:778738918
336 336 a, g, t dbSNP:140388341
357 357 c, t dbSNP:367999701
358 358 a, g dbSNP:928302
362 362 c, t dbSNP:142317371
394 394 a, g dbSNP:374679649
409 409 -, c dbSNP:727503493
413 413 c, g, t dbSNP:185332310
414 414 c, t dbSNP:200937562
415 415 a, g dbSNP:746526904
432 432 c, t dbSNP:139934512
435 435 a, c, g dbSNP:567503320
439 439 a, c, t dbSNP:143733205
440 440 a, g, t dbSNP:146159479
443 443 c, g dbSNP:757110501
453 453 a, g dbSNP:537210157
458 458 a, t dbSNP:397517372
459 459 c, t dbSNP:192083827
467 467 c, t dbSNP:757929050
469 469 a, g dbSNP:45598239
470 470 a, c dbSNP:764704910
472 472 c, t dbSNP:199903164
473 473 a, g, t dbSNP:397517373
478 478 a, g dbSNP:762109724
480 480 c, t dbSNP:145824109
481 481 a, g dbSNP:143762350
483 483 a, g dbSNP:143130957
488 488 c, t dbSNP:201811831
489 489 a, g dbSNP:769959543
492 492 c, t dbSNP:375429122
497 497 a, g dbSNP:745864701
499 499 c, g dbSNP:397517374
501 501 c, t dbSNP:146621712
502 502 a, g dbSNP:746713644
509 509 a, g dbSNP:387906915
510 510 c, t dbSNP:111033502
511 511 a, g dbSNP:373058706
513 513 a, g dbSNP:747805672
517 517 c, t dbSNP:139805921
518 518 a, g dbSNP:200028529
526 526 c, t dbSNP:201632198
527 527 a, g dbSNP:139484231
528 528 c, g, t dbSNP:759723029
531 531 a, g dbSNP:753920908
532 532 a, g dbSNP:35227181
534 534 c, t dbSNP:397517375
539 539 a, g dbSNP:760596000
545 545 c, g dbSNP:773186208
546 546 c, g, t dbSNP:142577467
547 547 a, g dbSNP:200090033
548 548 c, t dbSNP:201007237
558 558 a, g dbSNP:748912691
565 565 a, g dbSNP:779576286
569 569 c, t dbSNP:769346020
572 572 c, t dbSNP:747531199
573 573 a, g, t dbSNP:141682398
591 591 c, t dbSNP:753073419
592 592 a, c, g dbSNP:144556872
596 596 a, g dbSNP:754081459
604 604 a, g dbSNP:769177813
606 606 a, t dbSNP:766427297
612 612 c, t dbSNP:142784113
613 613 a, g, t dbSNP:140614903
614 614 a, c dbSNP:147231991
619 619 c, g dbSNP:774177677
626 626 a, g dbSNP:763842122
628 628 g, t dbSNP:762664593
633 633 -, a dbSNP:780609668
633 633 a, g, t dbSNP:61731564
638 638 a, g dbSNP:372586986
650 650 a, g dbSNP:368884558
652 652 c, g dbSNP:187406481
653 653 a, t dbSNP:181757077
654 654 a, g dbSNP:2839501
657 657 c, t dbSNP:776255076
660 660 a, c dbSNP:766994412
662 662 a, g dbSNP:770534938
667 667 c, t dbSNP:189002288
671 671 g, t dbSNP:774941186
680 680 c, t dbSNP:769146338
681 681 a, c, g, t dbSNP:376399439
693 693 c, g dbSNP:756404398
695 695 -, c dbSNP:34332832
696 696 c, t dbSNP:746043102
697 697 c, t dbSNP:781395690
698 698 a, g, t dbSNP:150397427
709 709 c, g dbSNP:763956555
712 712 c, t dbSNP:758223685
716 716 c, t dbSNP:752489902
717 717 a, c, t dbSNP:141476064
718 718 a, c, g dbSNP:766000719
723 723 a, c dbSNP:760194949
733 733 a, g dbSNP:764627057
735 735 c, t dbSNP:775028939
741 741 a, g dbSNP:201438268
742 742 a, g, t dbSNP:148313943
752 752 c, t dbSNP:770046529
756 756 c, t dbSNP:746156374
767 767 a, t dbSNP:781338726
768 768 c, g, t dbSNP:747054153
780 780 -, a dbSNP:397517376
790 790 c, g dbSNP:145109634
794 794 a, g dbSNP:200153943
796 796 a, g dbSNP:772040483
808 808 a, c, g dbSNP:141372828
841 841 a, g dbSNP:146604336
847 847 c, t dbSNP:145913750
848 848 a, g, t dbSNP:137853000
852 852 c, t dbSNP:376455414
853 853 a, g, t dbSNP:567975394
867 867 a, g dbSNP:373261804
870 870 c, t dbSNP:369273878
878 878 c, t dbSNP:763150678
879 879 a, g dbSNP:556073981
882 882 a, g dbSNP:201260442
906 906 c, g dbSNP:202037999
909 909 c, t dbSNP:776618952
912 912 c, g dbSNP:770646507
914 914 g, t dbSNP:772728753
916 916 c, t dbSNP:149001183
927 927 c, t dbSNP:533472191
928 928 a, g dbSNP:372526764
930 930 a, g dbSNP:747767404
932 932 a, g, t dbSNP:397517377
944 944 c, t dbSNP:768140716
945 945 a, g dbSNP:369903582
946 946 c, t dbSNP:376797288
954 954 c, g dbSNP:137852999
955 955 a, g dbSNP:371345947
957 957 c, g dbSNP:542121546
958 958 a, g dbSNP:2839500
959 959 c, t dbSNP:747352986
964 964 g, t dbSNP:778263709
965 965 c, t dbSNP:758738833
984 984 c, t dbSNP:397517378
987 987 c, g dbSNP:149869600
990 990 c, t dbSNP:147181936
993 993 c, t dbSNP:576826396
995 995 a, c dbSNP:769186992
997 997 a, t dbSNP:747580775
1001 1001 c, t dbSNP:773798591
1002 1002 a, g dbSNP:147785678
1011 1011 a, c dbSNP:144303402
1012 1012 a, c dbSNP:373744270
1017 1017 a, g dbSNP:756558488
1032 1032 c, g dbSNP:140552212
1033 1033 g, t dbSNP:768961609
1046 1046 c, t dbSNP:749465715
1050 1050 a, g dbSNP:780237490
1052 1052 c, t dbSNP:371475934
1057 1057 a, t dbSNP:147189374
1058 1058 g, t dbSNP:750362044
1068 1068 g, t dbSNP:781063590
1072 1072 c, g dbSNP:757064799
1074 1074 c, t dbSNP:751401936
1082 1082 a, g dbSNP:763769638
1083 1083 -, c dbSNP:772214350
1084 1084 a, g dbSNP:762736510
1095 1095 a, c dbSNP:752283050
1101 1101 a, g dbSNP:764821256
1102 1102 c, g dbSNP:573439830
1104 1104 g, t dbSNP:759050767
1109 1109 a, g dbSNP:773886793
1110 1110 a, t dbSNP:772660950
1116 1116 a, c, t dbSNP:774844255
1117 1117 a, g dbSNP:181949335
1119 1119 c, g dbSNP:749538864
1120 1120 c, g dbSNP:780073182
1134 1134 c, t dbSNP:145235893
1135 1135 a, g dbSNP:745895791
1136 1136 g, t dbSNP:566876247
1138 1138 c, t dbSNP:781225282
1140 1140 a, t dbSNP:757228573
1145 1145 a, c, t dbSNP:777685846
1146 1146 a, g dbSNP:766662530
1149 1149 c, g dbSNP:727504592
1151 1151 a, g dbSNP:550255214
1153 1153 a, g dbSNP:752399941
1170 1170 a, g dbSNP:115489719
1171 1171 c, t dbSNP:535549023
1172 1172 a, g dbSNP:753449161
1182 1182 a, g dbSNP:765982219
1187 1187 c, t dbSNP:754632759
1195 1195 c, t dbSNP:762466211
1204 1204 a, g dbSNP:774662763
1216 1216 c, g dbSNP:769068029
1218 1218 a, c dbSNP:763183670
1220 1220 c, t dbSNP:775799323
1224 1224 a, g dbSNP:770048737
1227 1227 a, g dbSNP:374268461
1231 1231 g, t dbSNP:776761130
1239 1239 c, g dbSNP:770987312
1253 1253 c, t dbSNP:746984799
1257 1257 c, t dbSNP:777509292
1263 1263 a, g dbSNP:758245776
1264 1264 c, t dbSNP:747849504
1267 1267 a, g dbSNP:778749578
1277 1277 c, t dbSNP:754719102
1286 1286 c, t dbSNP:753526746
1337 1337 c, t dbSNP:748246070

Target ORF information:

RefSeq Version NM_032405
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant D, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032405

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGGTACATCT
GGGTCTCTAT GTGGTTCTGC AGCTCTTCCT TTGTTTCAAG AGGATTTGCA ATTGCTCATT
GAAGCATTCT TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27004
Accession Version NM_032404.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 984bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA643571.1, AB038159.1, AK172842.1 and AI251446.1. On or before Jan 19, 2012 this sequence version replaced gi:224994255, gi:14602454. Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (C) lacks several 5' exons but contains an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant A. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_115780.1
CDS281..1264
Misc Feature(1)77..79(+)
Misc Feature(2)281..532(+)
Misc Feature(3)545..1231(+)
Misc Feature(4)548..1240(+)
Misc Feature(5)548..550(+)
Misc Feature(6)668..1102(+)
Misc Feature(7)1082..1165(+)
Exon (1)1..221
Gene:TMPRSS3
Gene Synonym:
Exon (2)222..345
Gene:TMPRSS3
Gene Synonym:
Exon (3)346..471
Gene:TMPRSS3
Gene Synonym:
Exon (4)472..515
Gene:TMPRSS3
Gene Synonym:
Exon (5)516..681
Gene:TMPRSS3
Gene Synonym:
Exon (6)682..851
Gene:TMPRSS3
Gene Synonym:
Exon (7)852..947
Gene:TMPRSS3
Gene Synonym:
Exon (8)948..1093
Gene:TMPRSS3
Gene Synonym:
Exon (9)1094..1246
Gene:TMPRSS3
Gene Synonym:
Exon (10)1247..2139
Gene:TMPRSS3
Gene Synonym:
Translation
Position Chain Variation Link
8 8 c, t dbSNP:561314115
10 10 a, c, t dbSNP:182241621
21 21 c, t dbSNP:373178051
22 22 a, g, t dbSNP:190584242
56 56 c, t dbSNP:749308843
57 57 a, c dbSNP:368317331
59 59 c, t dbSNP:755981585
68 68 a, g dbSNP:750207428
69 69 a, c, t dbSNP:757016727
82 82 c, g dbSNP:751137559
83 83 c, t dbSNP:7282234
85 85 a, g dbSNP:762355212
87 87 c, t dbSNP:754380902
91 91 c, t dbSNP:766728427
100 100 c, g dbSNP:761058429
102 102 c, t dbSNP:773616107
107 107 -, c dbSNP:727503493
111 111 c, g, t dbSNP:185332310
112 112 c, t dbSNP:200937562
113 113 a, g dbSNP:746526904
130 130 c, t dbSNP:139934512
133 133 a, c, g dbSNP:567503320
137 137 a, c, t dbSNP:143733205
138 138 a, g, t dbSNP:146159479
141 141 c, g dbSNP:757110501
151 151 a, g dbSNP:537210157
156 156 a, t dbSNP:397517372
157 157 c, t dbSNP:192083827
165 165 c, t dbSNP:757929050
167 167 a, g dbSNP:45598239
168 168 a, c dbSNP:764704910
170 170 c, t dbSNP:199903164
171 171 a, g, t dbSNP:397517373
176 176 a, g dbSNP:762109724
178 178 c, t dbSNP:145824109
179 179 a, g dbSNP:143762350
181 181 a, g dbSNP:143130957
186 186 c, t dbSNP:201811831
187 187 a, g dbSNP:769959543
190 190 c, t dbSNP:375429122
195 195 a, g dbSNP:745864701
197 197 c, g dbSNP:397517374
199 199 c, t dbSNP:146621712
200 200 a, g dbSNP:746713644
207 207 a, g dbSNP:387906915
208 208 c, t dbSNP:111033502
209 209 a, g dbSNP:373058706
211 211 a, g dbSNP:747805672
215 215 c, t dbSNP:139805921
216 216 a, g dbSNP:200028529
224 224 c, t dbSNP:201632198
225 225 a, g dbSNP:139484231
226 226 c, g, t dbSNP:759723029
229 229 a, g dbSNP:753920908
230 230 a, g dbSNP:35227181
232 232 c, t dbSNP:397517375
237 237 a, g dbSNP:760596000
243 243 c, g dbSNP:773186208
244 244 c, g, t dbSNP:142577467
245 245 a, g dbSNP:200090033
246 246 c, t dbSNP:201007237
256 256 a, g dbSNP:748912691
263 263 a, g dbSNP:779576286
267 267 c, t dbSNP:769346020
270 270 c, t dbSNP:747531199
271 271 a, g, t dbSNP:141682398
289 289 c, t dbSNP:753073419
290 290 a, c, g dbSNP:144556872
294 294 a, g dbSNP:754081459
302 302 a, g dbSNP:769177813
304 304 a, t dbSNP:766427297
310 310 c, t dbSNP:142784113
311 311 a, g, t dbSNP:140614903
312 312 a, c dbSNP:147231991
317 317 c, g dbSNP:774177677
324 324 a, g dbSNP:763842122
326 326 g, t dbSNP:762664593
331 331 -, a dbSNP:780609668
331 331 a, g, t dbSNP:61731564
336 336 a, g dbSNP:372586986
348 348 a, g dbSNP:368884558
350 350 c, g dbSNP:187406481
351 351 a, t dbSNP:181757077
352 352 a, g dbSNP:2839501
355 355 c, t dbSNP:776255076
358 358 a, c dbSNP:766994412
360 360 a, g dbSNP:770534938
365 365 c, t dbSNP:189002288
369 369 g, t dbSNP:774941186
378 378 c, t dbSNP:769146338
379 379 a, c, g, t dbSNP:376399439
391 391 c, g dbSNP:756404398
393 393 -, c dbSNP:34332832
394 394 c, t dbSNP:746043102
395 395 c, t dbSNP:781395690
396 396 a, g, t dbSNP:150397427
407 407 c, g dbSNP:763956555
410 410 c, t dbSNP:758223685
414 414 c, t dbSNP:752489902
415 415 a, c, t dbSNP:141476064
416 416 a, c, g dbSNP:766000719
421 421 a, c dbSNP:760194949
431 431 a, g dbSNP:764627057
433 433 c, t dbSNP:775028939
439 439 a, g dbSNP:201438268
440 440 a, g, t dbSNP:148313943
450 450 c, t dbSNP:770046529
454 454 c, t dbSNP:746156374
465 465 a, t dbSNP:781338726
466 466 c, g, t dbSNP:747054153
478 478 -, a dbSNP:397517376
488 488 c, g dbSNP:145109634
492 492 a, g dbSNP:200153943
494 494 a, g dbSNP:772040483
506 506 a, c, g dbSNP:141372828
539 539 a, g dbSNP:146604336
545 545 c, t dbSNP:145913750
546 546 a, g, t dbSNP:137853000
550 550 c, t dbSNP:376455414
551 551 a, g, t dbSNP:567975394
565 565 a, g dbSNP:373261804
568 568 c, t dbSNP:369273878
576 576 c, t dbSNP:763150678
577 577 a, g dbSNP:556073981
580 580 a, g dbSNP:201260442
604 604 c, g dbSNP:202037999
607 607 c, t dbSNP:776618952
610 610 c, g dbSNP:770646507
612 612 g, t dbSNP:772728753
614 614 c, t dbSNP:149001183
625 625 c, t dbSNP:533472191
626 626 a, g dbSNP:372526764
628 628 a, g dbSNP:747767404
630 630 a, g, t dbSNP:397517377
642 642 c, t dbSNP:768140716
643 643 a, g dbSNP:369903582
644 644 c, t dbSNP:376797288
652 652 c, g dbSNP:137852999
653 653 a, g dbSNP:371345947
655 655 c, g dbSNP:542121546
656 656 a, g dbSNP:2839500
657 657 c, t dbSNP:747352986
662 662 g, t dbSNP:778263709
663 663 c, t dbSNP:758738833
682 682 c, t dbSNP:397517378
685 685 c, g dbSNP:149869600
688 688 c, t dbSNP:147181936
691 691 c, t dbSNP:576826396
693 693 a, c dbSNP:769186992
695 695 a, t dbSNP:747580775
699 699 c, t dbSNP:773798591
700 700 a, g dbSNP:147785678
709 709 a, c dbSNP:144303402
710 710 a, c dbSNP:373744270
715 715 a, g dbSNP:756558488
730 730 c, g dbSNP:140552212
731 731 g, t dbSNP:768961609
744 744 c, t dbSNP:749465715
748 748 a, g dbSNP:780237490
750 750 c, t dbSNP:371475934
755 755 a, t dbSNP:147189374
756 756 g, t dbSNP:750362044
766 766 g, t dbSNP:781063590
770 770 c, g dbSNP:757064799
772 772 c, t dbSNP:751401936
780 780 a, g dbSNP:763769638
781 781 -, c dbSNP:772214350
782 782 a, g dbSNP:762736510
793 793 a, c dbSNP:752283050
799 799 a, g dbSNP:764821256
800 800 c, g dbSNP:573439830
802 802 g, t dbSNP:759050767
807 807 a, g dbSNP:773886793
808 808 a, t dbSNP:772660950
814 814 a, c, t dbSNP:774844255
815 815 a, g dbSNP:181949335
817 817 c, g dbSNP:749538864
818 818 c, g dbSNP:780073182
832 832 c, t dbSNP:145235893
833 833 a, g dbSNP:745895791
834 834 g, t dbSNP:566876247
836 836 c, t dbSNP:781225282
838 838 a, t dbSNP:757228573
843 843 a, c, t dbSNP:777685846
844 844 a, g dbSNP:766662530
847 847 c, g dbSNP:727504592
849 849 a, g dbSNP:550255214
851 851 a, g dbSNP:752399941
856 856 c, g dbSNP:115223836
857 857 a, t dbSNP:771954317
859 859 c, t dbSNP:117766615
863 863 c, t dbSNP:778907728
868 868 g, t dbSNP:371149049
872 872 c, t dbSNP:140676332
874 874 g, t dbSNP:397517379
880 880 c, t dbSNP:755667543
883 883 c, t dbSNP:749947184
891 891 a, g dbSNP:767019311
892 892 c, t dbSNP:397517380
897 897 a, c, g, t dbSNP:144682332
898 898 -, c dbSNP:748150602
898 898 c, t dbSNP:192630206
899 899 a, g dbSNP:776873836
901 901 a, t dbSNP:376916029
903 903 c, g dbSNP:369161852
907 907 -, a dbSNP:774670393
918 918 c, t dbSNP:200002841
919 919 a, g dbSNP:374149338
924 924 a, g dbSNP:397517368
925 925 a, t dbSNP:565271986
927 927 g, t dbSNP:540715620
931 931 a, g dbSNP:774362783
932 932 -, g dbSNP:768759797
932 932 a, g dbSNP:573318480
937 937 a, t dbSNP:200554019
940 940 a, g, t dbSNP:779969755
941 941 a, g dbSNP:111033261
947 947 a, g dbSNP:377604843
953 953 a, g dbSNP:745522641
954 954 a, g dbSNP:752332652
955 955 c, t dbSNP:397517369
956 956 a, g dbSNP:188750127
961 961 c, g dbSNP:199751071
973 973 a, c dbSNP:777243740
974 974 c, t dbSNP:755519837
976 976 c, t dbSNP:754341063
978 978 c, t dbSNP:200777266
979 979 a, g dbSNP:756432794
982 982 c, t dbSNP:750642034
983 983 a, g dbSNP:767728685
986 986 a, c dbSNP:757529665
989 989 g, t dbSNP:397517370
1015 1015 c, t dbSNP:145077154
1020 1020 a, g dbSNP:764262141
1021 1021 c, t dbSNP:113747896
1022 1022 a, g dbSNP:775508015
1027 1027 c, t dbSNP:111033292
1028 1028 a, g dbSNP:371448615
1034 1034 a, g dbSNP:776173937
1035 1035 c, t dbSNP:770666997
1045 1045 c, t dbSNP:746633574
1046 1046 a, t dbSNP:772776809
1047 1047 c, t dbSNP:771559352
1050 1050 a, t dbSNP:749798053
1051 1051 g, t dbSNP:727503492
1054 1054 c, g dbSNP:780568459
1055 1055 g, t dbSNP:756455958
1057 1057 c, t dbSNP:746293388
1058 1058 a, g dbSNP:781376204
1059 1059 c, t dbSNP:201172277
1060 1060 a, c, g dbSNP:568884207
1066 1066 c, t dbSNP:758488441
1067 1067 a, c, t dbSNP:371402895
1069 1069 c, g dbSNP:374082620
1071 1071 c, t dbSNP:145766262
1072 1072 a, g dbSNP:140620963
1073 1073 a, g dbSNP:760379793
1079 1079 a, g dbSNP:151315833
1082 1082 c, g dbSNP:111033537
1086 1086 a, g dbSNP:747606494
1089 1089 g, t dbSNP:773711263
1091 1091 c, t dbSNP:727504304
1093 1093 a, g dbSNP:770372956
1095 1095 a, g dbSNP:763663882
1099 1099 c, g dbSNP:397517371
1104 1104 a, g dbSNP:777302040
1110 1110 c, t dbSNP:28939084
1112 1112 c, t dbSNP:761233720
1118 1118 c, t dbSNP:773780151
1126 1126 -, g dbSNP:780413386
1135 1135 c, g, t dbSNP:748419198
1137 1137 a, g dbSNP:778939088
1141 1141 a, g dbSNP:768801900
1152 1152 c, g, t dbSNP:377531325
1153 1153 a, g dbSNP:756106839
1156 1156 c, t dbSNP:745791794
1165 1165 c, t dbSNP:143447868
1168 1168 c, t dbSNP:372469227
1169 1169 a, g dbSNP:751253556
1174 1174 c, g, t dbSNP:56178910
1175 1175 a, g dbSNP:56264519
1181 1181 a, g dbSNP:764834949
1182 1182 g, t dbSNP:761325889
1185 1185 a, g dbSNP:144344468
1190 1190 c, t dbSNP:767931569
1192 1192 c, t dbSNP:762046668
1194 1194 c, g dbSNP:774754033
1195 1195 c, g dbSNP:369050452
1203 1203 c, t dbSNP:374775170
1205 1205 c, t dbSNP:565348874
1206 1206 a, g dbSNP:769807644
1208 1208 a, g dbSNP:114904237
1213 1213 c, t dbSNP:781065790
1234 1234 c, t dbSNP:186972955
1235 1235 a, c, g dbSNP:777595673
1237 1237 a, g dbSNP:758055060
1238 1238 c, g dbSNP:147621273
1242 1242 c, t dbSNP:201018751
1243 1243 a, g dbSNP:267606141
1262 1262 c, t dbSNP:149919890
1266 1266 a, g dbSNP:13047838
1273 1273 c, g dbSNP:376617444
1280 1280 a, g dbSNP:373631775
1286 1286 a, c dbSNP:760543023
1287 1287 c, t dbSNP:773138888
1289 1289 c, t dbSNP:772027252
1292 1292 a, g dbSNP:747907091
1298 1298 a, g dbSNP:560422036
1303 1303 a, g dbSNP:768487011
1310 1310 a, g dbSNP:748952887
1316 1316 c, t dbSNP:779440962
1317 1317 a, g dbSNP:137903612
1319 1319 a, t dbSNP:574793792
1320 1320 c, t dbSNP:562911942
1335 1335 a, c, g, t dbSNP:765583795
1336 1336 a, g dbSNP:146942080
1338 1338 a, g dbSNP:754035154
1345 1345 c, t dbSNP:766378265
1346 1346 c, g, t dbSNP:773048535
1353 1353 c, t dbSNP:772188430
1354 1354 a, g dbSNP:752845603
1355 1355 a, g dbSNP:774342587
1364 1364 c, t dbSNP:577236954
1367 1367 c, t dbSNP:748894351
1372 1372 c, t dbSNP:775167159
1377 1377 -, ag dbSNP:756407302
1382 1382 c, t dbSNP:537768966
1383 1383 a, g dbSNP:745429674
1385 1385 c, g dbSNP:780648559
1387 1387 c, t dbSNP:758971690
1388 1388 a, c, t dbSNP:779262487
1398 1398 a, c dbSNP:755304820
1400 1400 c, t dbSNP:754041925
1401 1401 a, g dbSNP:374108302
1405 1405 a, g dbSNP:756270012
1427 1427 c, t dbSNP:750580679
1430 1430 a, c dbSNP:767689219
1443 1443 a, c dbSNP:761851082
1452 1452 -, ctttttg dbSNP:746406661
1453 1453 c, t dbSNP:114813487
1455 1455 c, t dbSNP:116789917
1461 1461 c, t dbSNP:112618394
1466 1466 -, t dbSNP:781505001
1466 1466 -, t dbSNP:756840804
1470 1470 a, g dbSNP:225309
1472 1472 g, t dbSNP:775122912
1475 1475 g, t dbSNP:769525510
1477 1477 c, t dbSNP:745504094
1479 1479 c, t dbSNP:776179259
1480 1480 a, g, t dbSNP:748659120
1481 1481 c, t dbSNP:527529577
1493 1493 c, g dbSNP:779356250
1504 1504 a, g dbSNP:536353688
1509 1509 c, t dbSNP:755324540
1510 1510 a, g dbSNP:57692239
1516 1516 c, t dbSNP:377203280
1523 1523 a, c dbSNP:75706305
1528 1528 a, g dbSNP:186721880
1534 1534 -, tcc dbSNP:763182738
1534 1534 c, t dbSNP:538228372
1540 1540 c, t dbSNP:750613856
1547 1547 c, t dbSNP:767705563
1551 1551 c, t dbSNP:757369320
1562 1562 c, t dbSNP:751564896
1597 1597 c, t dbSNP:534653513
1598 1598 a, g dbSNP:182472675
1599 1599 a, c dbSNP:762767504
1615 1615 a, c dbSNP:551510160
1635 1635 a, g dbSNP:775421153
1666 1666 c, t dbSNP:764929225
1671 1671 a, t dbSNP:145515753
1673 1673 c, t dbSNP:55954914
1675 1675 a, c dbSNP:140838491
1693 1693 a, c dbSNP:760132655
1706 1706 c, t dbSNP:772690986
1719 1719 a, g dbSNP:773503618
1724 1724 c, t dbSNP:749758096
1740 1740 c, t dbSNP:555701604
1741 1741 a, g dbSNP:537211737
1744 1744 c, t dbSNP:746120755
1752 1752 c, t dbSNP:781515551
1753 1753 a, c, g dbSNP:562818521
1756 1756 c, t dbSNP:115398434
1757 1757 c, t dbSNP:146497192
1759 1759 g, t dbSNP:777709647
1771 1771 c, g dbSNP:193295918
1803 1803 c, t dbSNP:540533831
1804 1804 a, g dbSNP:144138830
1839 1839 -, g dbSNP:397867467
1842 1842 -, g dbSNP:34908991
1860 1860 c, t dbSNP:765085568
1885 1885 c, t dbSNP:554763027
1918 1918 c, t dbSNP:139451134
1928 1928 c, t dbSNP:753514974
1934 1934 g, t dbSNP:551632669
1950 1950 c, t dbSNP:768387052
1955 1955 a, c dbSNP:533265958
1987 1987 a, c dbSNP:188772709
1994 1994 a, c dbSNP:61654202
2001 2001 c, t dbSNP:556767717
2019 2019 g, t dbSNP:146774207
2041 2041 g, t dbSNP:35447393
2057 2057 a, g dbSNP:771631125
2069 2069 c, t dbSNP:771422917
2079 2079 a, g dbSNP:116974943
2092 2092 c, t dbSNP:778803206
2093 2093 a, g dbSNP:562018552
2098 2098 a, g dbSNP:770213553
2121 2121 -, at dbSNP:758000102

Target ORF information:

RefSeq Version NM_032404
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant C, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_032404

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGCTCCG ATGACTGGAA GGGTCACTAC GCAAATGTTG CCTGTGCCCA ACTGGGTTTC 
CCAAGCTATG TGAGTTCAGA TAACCTCAGA GTGAGCTCGC TGGAGGGGCA GTTCCGGGAG
GAGTTTGTGT CCATCGATCA CCTCTTGCCA GATGACAAGG TGACTGCATT ACACCACTCA
GTATATGTGA GGGAGGGATG TGCCTCTGGC CACGTGGTTA CCTTGCAGTG CACAGCCTGT
GGTCATAGAA GGGGCTACAG CTCACGCATC GTGGGTGGAA ACATGTCCTT GCTCTCGCAG
TGGCCCTGGC AGGCCAGCCT TCAGTTCCAG GGCTACCACC TGTGCGGGGG CTCTGTCATC
ACGCCCCTGT GGATCATCAC TGCTGCACAC TGTGTTTATG ACTTGTACCT CCCCAAGTCA
TGGACCATCC AGGTGGGTCT AGTTTCCCTG TTGGACAATC CAGCCCCATC CCACTTGGTG
GAGAAGATTG TCTACCACAG CAAGTACAAG CCAAAGAGGC TGGGCAATGA CATCGCCCTT
ATGAAGCTGG CCGGGCCACT CACGTTCAAT GAAATGATCC AGCCTGTGTG CCTGCCCAAC
TCTGAAGAGA ACTTCCCCGA TGGAAAAGTG TGCTGGACGT CAGGATGGGG GGCCACAGAG
GATGGAGCAG GTGACGCCTC CCCTGTCCTG AACCACGCGG CCGTCCCTTT GATTTCCAAC
AAGATCTGCA ACCACAGGGA CGTGTACGGT GGCATCATCT CCCCCTCCAT GCTCTGCGCG
GGCTACCTGA CGGGTGGCGT GGACAGCTGC CAGGGGGACA GCGGGGGGCC CCTGGTGTGT
CAAGAGAGGA GGCTGTGGAA GTTAGTGGGA GCGACCAGCT TTGGCATCGG CTGCGCAGAG
GTGAACAAGC CTGGGGTGTA CACCCGTGTC ACCTCCTTCC TGGACTGGAT CCACGAGCAG
ATGGAGAGAG ACCTAAAAAC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27241
Accession Version NM_001256317.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1362bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AY358458.1, AK172842.1, AB038159.1 and AI251446.1. Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (F) uses an alternate in-frame splice site in the central coding region, compared to variant A, resulting in an isoform (4) that is 1 aa shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172842.1, AF201380.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001243246.1
CDS202..1563
Misc Feature(1)346..408(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..1530(+)
Misc Feature(8)847..852(+)
Misc Feature(9)850..1539(+)
Misc Feature(10)850..852(+)
Misc Feature(11)970..1401(+)
Misc Feature(12)1381..1464(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1153
Gene:TMPRSS3
Gene Synonym:
Exon (10)1154..1249
Gene:TMPRSS3
Gene Synonym:
Exon (11)1250..1392
Gene:TMPRSS3
Gene Synonym:
Exon (12)1393..1545
Gene:TMPRSS3
Gene Synonym:
Exon (13)1546..2438
Gene:TMPRSS3
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:755944650
4 4 a, g, t dbSNP:56100074
10 10 c, t dbSNP:540503594
11 11 a, g dbSNP:754521287
13 13 a, t dbSNP:753306106
14 14 c, t dbSNP:377532101
15 15 a, g dbSNP:762360884
16 16 g, t dbSNP:752032749
19 19 a, c dbSNP:767574751
20 20 a, c, g dbSNP:147296608
27 27 c, t dbSNP:765305889
28 28 g, t dbSNP:759691958
30 30 a, g dbSNP:191054653
33 33 c, t dbSNP:56347158
37 37 a, g dbSNP:771111101
45 45 a, g dbSNP:746981844
50 50 c, t dbSNP:773269515
51 51 a, g dbSNP:771916158
55 55 a, g dbSNP:200277359
59 59 c, t dbSNP:778659792
60 60 a, c dbSNP:754542420
64 64 a, c dbSNP:748920724
66 66 c, g dbSNP:779582533
69 69 c, t dbSNP:755619879
71 71 a, c, g dbSNP:56369547
79 79 g, t dbSNP:758790604
87 87 a, g dbSNP:752961392
92 92 c, t dbSNP:765518679
93 93 a, g dbSNP:759886263
103 103 a, g dbSNP:375438526
106 106 a, g dbSNP:776962558
114 114 c, t dbSNP:766631539
115 115 a, g dbSNP:371722059
120 120 a, g dbSNP:773287558
123 123 a, g dbSNP:771866484
124 124 a, t dbSNP:557132994
129 129 a, g dbSNP:774066728
136 136 c, g dbSNP:768469011
141 141 c, t dbSNP:749010685
142 142 a, g dbSNP:779671143
148 148 c, t dbSNP:755630225
151 151 a, g dbSNP:371778905
157 157 c, g dbSNP:756454876
159 159 g, t dbSNP:750630070
161 161 g, t dbSNP:538734255
166 166 c, g dbSNP:186244930
167 167 c, g dbSNP:751468633
168 168 a, g dbSNP:73372256
173 173 c, t dbSNP:376404558
174 174 a, g dbSNP:775213790
175 175 a, g dbSNP:769552964
178 178 a, g dbSNP:759150161
180 180 c, t dbSNP:373324024
192 192 a, g dbSNP:770405018
204 204 g, t dbSNP:746461825
208 208 a, g dbSNP:779595310
212 212 a, t dbSNP:769238563
218 218 c, t dbSNP:139865555
219 219 a, g, t dbSNP:200199344
222 222 a, t dbSNP:143981919
226 226 c, g dbSNP:149481350
229 229 a, g dbSNP:781420452
233 233 a, c dbSNP:372629505
234 234 c, t dbSNP:138052370
237 237 c, t dbSNP:764038602
240 240 c, g dbSNP:150765531
242 242 c, t dbSNP:752598801
248 248 a, g, t dbSNP:369418733
251 251 a, c, t dbSNP:766015335
252 252 a, g dbSNP:182209675
253 253 a, c, t dbSNP:372359927
264 264 c, t dbSNP:749880255
266 266 a, g dbSNP:776129573
268 268 a, g dbSNP:770072040
272 272 -, t dbSNP:771977117
284 284 a, c, t dbSNP:137882698
286 286 c, g dbSNP:757448130
302 302 a, t dbSNP:142917173
318 318 g, t dbSNP:747297139
322 322 c, t dbSNP:779277523
324 324 g, t dbSNP:201147366
325 325 c, t dbSNP:758485931
334 334 c, t dbSNP:748158424
335 335 c, t dbSNP:778738918
336 336 a, g, t dbSNP:140388341
357 357 c, t dbSNP:367999701
358 358 a, g dbSNP:928302
362 362 c, t dbSNP:142317371
394 394 a, g dbSNP:374679649
409 409 -, c dbSNP:727503493
413 413 c, g, t dbSNP:185332310
414 414 c, t dbSNP:200937562
415 415 a, g dbSNP:746526904
432 432 c, t dbSNP:139934512
435 435 a, c, g dbSNP:567503320
439 439 a, c, t dbSNP:143733205
440 440 a, g, t dbSNP:146159479
443 443 c, g dbSNP:757110501
453 453 a, g dbSNP:537210157
458 458 a, t dbSNP:397517372
459 459 c, t dbSNP:192083827
467 467 c, t dbSNP:757929050
469 469 a, g dbSNP:45598239
470 470 a, c dbSNP:764704910
472 472 c, t dbSNP:199903164
473 473 a, g, t dbSNP:397517373
478 478 a, g dbSNP:762109724
480 480 c, t dbSNP:145824109
481 481 a, g dbSNP:143762350
483 483 a, g dbSNP:143130957
488 488 c, t dbSNP:201811831
489 489 a, g dbSNP:769959543
492 492 c, t dbSNP:375429122
497 497 a, g dbSNP:745864701
499 499 c, g dbSNP:397517374
501 501 c, t dbSNP:146621712
502 502 a, g dbSNP:746713644
509 509 a, g dbSNP:387906915
510 510 c, t dbSNP:111033502
511 511 a, g dbSNP:373058706
513 513 a, g dbSNP:747805672
517 517 c, t dbSNP:139805921
518 518 a, g dbSNP:200028529
526 526 c, t dbSNP:201632198
527 527 a, g dbSNP:139484231
528 528 c, g, t dbSNP:759723029
531 531 a, g dbSNP:753920908
532 532 a, g dbSNP:35227181
534 534 c, t dbSNP:397517375
539 539 a, g dbSNP:760596000
545 545 c, g dbSNP:773186208
546 546 c, g, t dbSNP:142577467
547 547 a, g dbSNP:200090033
548 548 c, t dbSNP:201007237
558 558 a, g dbSNP:748912691
565 565 a, g dbSNP:779576286
569 569 c, t dbSNP:769346020
572 572 c, t dbSNP:747531199
573 573 a, g, t dbSNP:141682398
591 591 c, t dbSNP:753073419
592 592 a, c, g dbSNP:144556872
596 596 a, g dbSNP:754081459
604 604 a, g dbSNP:769177813
606 606 a, t dbSNP:766427297
612 612 c, t dbSNP:142784113
613 613 a, g, t dbSNP:140614903
614 614 a, c dbSNP:147231991
619 619 c, g dbSNP:774177677
626 626 a, g dbSNP:763842122
628 628 g, t dbSNP:762664593
633 633 -, a dbSNP:780609668
633 633 a, g, t dbSNP:61731564
638 638 a, g dbSNP:372586986
650 650 a, g dbSNP:368884558
652 652 c, g dbSNP:187406481
653 653 a, t dbSNP:181757077
654 654 a, g dbSNP:2839501
657 657 c, t dbSNP:776255076
660 660 a, c dbSNP:766994412
662 662 a, g dbSNP:770534938
667 667 c, t dbSNP:189002288
671 671 g, t dbSNP:774941186
680 680 c, t dbSNP:769146338
681 681 a, c, g, t dbSNP:376399439
693 693 c, g dbSNP:756404398
695 695 -, c dbSNP:34332832
696 696 c, t dbSNP:746043102
697 697 c, t dbSNP:781395690
698 698 a, g, t dbSNP:150397427
709 709 c, g dbSNP:763956555
712 712 c, t dbSNP:758223685
716 716 c, t dbSNP:752489902
717 717 a, c, t dbSNP:141476064
718 718 a, c, g dbSNP:766000719
723 723 a, c dbSNP:760194949
733 733 a, g dbSNP:764627057
735 735 c, t dbSNP:775028939
741 741 a, g dbSNP:201438268
742 742 a, g, t dbSNP:148313943
752 752 c, t dbSNP:770046529
756 756 c, t dbSNP:746156374
767 767 a, t dbSNP:781338726
768 768 c, g, t dbSNP:747054153
780 780 -, a dbSNP:397517376
790 790 c, g dbSNP:145109634
794 794 a, g dbSNP:200153943
796 796 a, g dbSNP:772040483
808 808 a, c, g dbSNP:141372828
841 841 a, g dbSNP:146604336
847 847 c, t dbSNP:145913750
848 848 a, g, t dbSNP:137853000
852 852 c, t dbSNP:376455414
853 853 a, g, t dbSNP:567975394
867 867 a, g dbSNP:373261804
870 870 c, t dbSNP:369273878
878 878 c, t dbSNP:763150678
879 879 a, g dbSNP:556073981
882 882 a, g dbSNP:201260442
906 906 c, g dbSNP:202037999
909 909 c, t dbSNP:776618952
912 912 c, g dbSNP:770646507
914 914 g, t dbSNP:772728753
916 916 c, t dbSNP:149001183
927 927 c, t dbSNP:533472191
928 928 a, g dbSNP:372526764
930 930 a, g dbSNP:747767404
932 932 a, g, t dbSNP:397517377
944 944 c, t dbSNP:768140716
945 945 a, g dbSNP:369903582
946 946 c, t dbSNP:376797288
954 954 c, g dbSNP:137852999
955 955 a, g dbSNP:371345947
957 957 c, g dbSNP:542121546
958 958 a, g dbSNP:2839500
959 959 c, t dbSNP:747352986
964 964 g, t dbSNP:778263709
965 965 c, t dbSNP:758738833
984 984 c, t dbSNP:397517378
987 987 c, g dbSNP:149869600
990 990 c, t dbSNP:147181936
993 993 c, t dbSNP:576826396
995 995 a, c dbSNP:769186992
997 997 a, t dbSNP:747580775
1001 1001 c, t dbSNP:773798591
1002 1002 a, g dbSNP:147785678
1011 1011 a, c dbSNP:144303402
1012 1012 a, c dbSNP:373744270
1017 1017 a, g dbSNP:756558488
1032 1032 c, g dbSNP:140552212
1033 1033 g, t dbSNP:768961609
1046 1046 c, t dbSNP:749465715
1050 1050 a, g dbSNP:780237490
1052 1052 c, t dbSNP:371475934
1057 1057 a, t dbSNP:147189374
1058 1058 g, t dbSNP:750362044
1068 1068 g, t dbSNP:781063590
1072 1072 c, g dbSNP:757064799
1074 1074 c, t dbSNP:751401936
1082 1082 a, g dbSNP:763769638
1083 1083 -, c dbSNP:772214350
1084 1084 a, g dbSNP:762736510
1095 1095 a, c dbSNP:752283050
1101 1101 a, g dbSNP:764821256
1102 1102 c, g dbSNP:573439830
1104 1104 g, t dbSNP:759050767
1109 1109 a, g dbSNP:773886793
1110 1110 a, t dbSNP:772660950
1116 1116 a, c, t dbSNP:774844255
1117 1117 a, g dbSNP:181949335
1119 1119 c, g dbSNP:749538864
1120 1120 c, g dbSNP:780073182
1134 1134 c, t dbSNP:145235893
1135 1135 a, g dbSNP:745895791
1136 1136 g, t dbSNP:566876247
1138 1138 c, t dbSNP:781225282
1140 1140 a, t dbSNP:757228573
1145 1145 a, c, t dbSNP:777685846
1146 1146 a, g dbSNP:766662530
1149 1149 c, g dbSNP:727504592
1151 1151 a, g dbSNP:550255214
1153 1153 a, g dbSNP:752399941
1158 1158 c, g dbSNP:115223836
1159 1159 a, t dbSNP:771954317
1161 1161 c, t dbSNP:117766615
1165 1165 c, t dbSNP:778907728
1170 1170 g, t dbSNP:371149049
1174 1174 c, t dbSNP:140676332
1176 1176 g, t dbSNP:397517379
1182 1182 c, t dbSNP:755667543
1185 1185 c, t dbSNP:749947184
1193 1193 a, g dbSNP:767019311
1194 1194 c, t dbSNP:397517380
1199 1199 a, c, g, t dbSNP:144682332
1200 1200 -, c dbSNP:748150602
1200 1200 c, t dbSNP:192630206
1201 1201 a, g dbSNP:776873836
1203 1203 a, t dbSNP:376916029
1205 1205 c, g dbSNP:369161852
1209 1209 -, a dbSNP:774670393
1220 1220 c, t dbSNP:200002841
1221 1221 a, g dbSNP:374149338
1226 1226 a, g dbSNP:397517368
1227 1227 a, t dbSNP:565271986
1229 1229 g, t dbSNP:540715620
1233 1233 a, g dbSNP:774362783
1234 1234 -, g dbSNP:768759797
1234 1234 a, g dbSNP:573318480
1239 1239 a, t dbSNP:200554019
1242 1242 a, g, t dbSNP:779969755
1243 1243 a, g dbSNP:111033261
1249 1249 a, g dbSNP:377604843
1252 1252 a, g dbSNP:745522641
1253 1253 a, g dbSNP:752332652
1254 1254 c, t dbSNP:397517369
1255 1255 a, g dbSNP:188750127
1260 1260 c, g dbSNP:199751071
1272 1272 a, c dbSNP:777243740
1273 1273 c, t dbSNP:755519837
1275 1275 c, t dbSNP:754341063
1277 1277 c, t dbSNP:200777266
1278 1278 a, g dbSNP:756432794
1281 1281 c, t dbSNP:750642034
1282 1282 a, g dbSNP:767728685
1285 1285 a, c dbSNP:757529665
1288 1288 g, t dbSNP:397517370
1314 1314 c, t dbSNP:145077154
1319 1319 a, g dbSNP:764262141
1320 1320 c, t dbSNP:113747896
1321 1321 a, g dbSNP:775508015
1326 1326 c, t dbSNP:111033292
1327 1327 a, g dbSNP:371448615
1333 1333 a, g dbSNP:776173937
1334 1334 c, t dbSNP:770666997
1344 1344 c, t dbSNP:746633574
1345 1345 a, t dbSNP:772776809
1346 1346 c, t dbSNP:771559352
1349 1349 a, t dbSNP:749798053
1350 1350 g, t dbSNP:727503492
1353 1353 c, g dbSNP:780568459
1354 1354 g, t dbSNP:756455958
1356 1356 c, t dbSNP:746293388
1357 1357 a, g dbSNP:781376204
1358 1358 c, t dbSNP:201172277
1359 1359 a, c, g dbSNP:568884207
1365 1365 c, t dbSNP:758488441
1366 1366 a, c, t dbSNP:371402895
1368 1368 c, g dbSNP:374082620
1370 1370 c, t dbSNP:145766262
1371 1371 a, g dbSNP:140620963
1372 1372 a, g dbSNP:760379793
1378 1378 a, g dbSNP:151315833
1381 1381 c, g dbSNP:111033537
1385 1385 a, g dbSNP:747606494
1388 1388 g, t dbSNP:773711263
1390 1390 c, t dbSNP:727504304
1392 1392 a, g dbSNP:770372956
1394 1394 a, g dbSNP:763663882
1398 1398 c, g dbSNP:397517371
1403 1403 a, g dbSNP:777302040
1409 1409 c, t dbSNP:28939084
1411 1411 c, t dbSNP:761233720
1417 1417 c, t dbSNP:773780151
1425 1425 -, g dbSNP:780413386
1434 1434 c, g, t dbSNP:748419198
1436 1436 a, g dbSNP:778939088
1440 1440 a, g dbSNP:768801900
1451 1451 c, g, t dbSNP:377531325
1452 1452 a, g dbSNP:756106839
1455 1455 c, t dbSNP:745791794
1464 1464 c, t dbSNP:143447868
1467 1467 c, t dbSNP:372469227
1468 1468 a, g dbSNP:751253556
1473 1473 c, g, t dbSNP:56178910
1474 1474 a, g dbSNP:56264519
1480 1480 a, g dbSNP:764834949
1481 1481 g, t dbSNP:761325889
1484 1484 a, g dbSNP:144344468
1489 1489 c, t dbSNP:767931569
1491 1491 c, t dbSNP:762046668
1493 1493 c, g dbSNP:774754033
1494 1494 c, g dbSNP:369050452
1502 1502 c, t dbSNP:374775170
1504 1504 c, t dbSNP:565348874
1505 1505 a, g dbSNP:769807644
1507 1507 a, g dbSNP:114904237
1512 1512 c, t dbSNP:781065790
1533 1533 c, t dbSNP:186972955
1534 1534 a, c, g dbSNP:777595673
1536 1536 a, g dbSNP:758055060
1537 1537 c, g dbSNP:147621273
1541 1541 c, t dbSNP:201018751
1542 1542 a, g dbSNP:267606141
1561 1561 c, t dbSNP:149919890
1565 1565 a, g dbSNP:13047838
1572 1572 c, g dbSNP:376617444
1579 1579 a, g dbSNP:373631775
1585 1585 a, c dbSNP:760543023
1586 1586 c, t dbSNP:773138888
1588 1588 c, t dbSNP:772027252
1591 1591 a, g dbSNP:747907091
1597 1597 a, g dbSNP:560422036
1602 1602 a, g dbSNP:768487011
1609 1609 a, g dbSNP:748952887
1615 1615 c, t dbSNP:779440962
1616 1616 a, g dbSNP:137903612
1618 1618 a, t dbSNP:574793792
1619 1619 c, t dbSNP:562911942
1634 1634 a, c, g, t dbSNP:765583795
1635 1635 a, g dbSNP:146942080
1637 1637 a, g dbSNP:754035154
1644 1644 c, t dbSNP:766378265
1645 1645 c, g, t dbSNP:773048535
1652 1652 c, t dbSNP:772188430
1653 1653 a, g dbSNP:752845603
1654 1654 a, g dbSNP:774342587
1663 1663 c, t dbSNP:577236954
1666 1666 c, t dbSNP:748894351
1671 1671 c, t dbSNP:775167159
1676 1676 -, ag dbSNP:756407302
1681 1681 c, t dbSNP:537768966
1682 1682 a, g dbSNP:745429674
1684 1684 c, g dbSNP:780648559
1686 1686 c, t dbSNP:758971690
1687 1687 a, c, t dbSNP:779262487
1697 1697 a, c dbSNP:755304820
1699 1699 c, t dbSNP:754041925
1700 1700 a, g dbSNP:374108302
1704 1704 a, g dbSNP:756270012
1726 1726 c, t dbSNP:750580679
1729 1729 a, c dbSNP:767689219
1742 1742 a, c dbSNP:761851082
1751 1751 -, ctttttg dbSNP:746406661
1752 1752 c, t dbSNP:114813487
1754 1754 c, t dbSNP:116789917
1760 1760 c, t dbSNP:112618394
1765 1765 -, t dbSNP:781505001
1765 1765 -, t dbSNP:756840804
1769 1769 a, g dbSNP:225309
1771 1771 g, t dbSNP:775122912
1774 1774 g, t dbSNP:769525510
1776 1776 c, t dbSNP:745504094
1778 1778 c, t dbSNP:776179259
1779 1779 a, g, t dbSNP:748659120
1780 1780 c, t dbSNP:527529577
1792 1792 c, g dbSNP:779356250
1803 1803 a, g dbSNP:536353688
1808 1808 c, t dbSNP:755324540
1809 1809 a, g dbSNP:57692239
1815 1815 c, t dbSNP:377203280
1822 1822 a, c dbSNP:75706305
1827 1827 a, g dbSNP:186721880
1833 1833 -, tcc dbSNP:763182738
1833 1833 c, t dbSNP:538228372
1839 1839 c, t dbSNP:750613856
1846 1846 c, t dbSNP:767705563
1850 1850 c, t dbSNP:757369320
1861 1861 c, t dbSNP:751564896
1896 1896 c, t dbSNP:534653513
1897 1897 a, g dbSNP:182472675
1898 1898 a, c dbSNP:762767504
1914 1914 a, c dbSNP:551510160
1934 1934 a, g dbSNP:775421153
1965 1965 c, t dbSNP:764929225
1970 1970 a, t dbSNP:145515753
1972 1972 c, t dbSNP:55954914
1974 1974 a, c dbSNP:140838491
1992 1992 a, c dbSNP:760132655
2005 2005 c, t dbSNP:772690986
2018 2018 a, g dbSNP:773503618
2023 2023 c, t dbSNP:749758096
2039 2039 c, t dbSNP:555701604
2040 2040 a, g dbSNP:537211737
2043 2043 c, t dbSNP:746120755
2051 2051 c, t dbSNP:781515551
2052 2052 a, c, g dbSNP:562818521
2055 2055 c, t dbSNP:115398434
2056 2056 c, t dbSNP:146497192
2058 2058 g, t dbSNP:777709647
2070 2070 c, g dbSNP:193295918
2102 2102 c, t dbSNP:540533831
2103 2103 a, g dbSNP:144138830
2138 2138 -, g dbSNP:397867467
2141 2141 -, g dbSNP:34908991
2159 2159 c, t dbSNP:765085568
2184 2184 c, t dbSNP:554763027
2217 2217 c, t dbSNP:139451134
2227 2227 c, t dbSNP:753514974
2233 2233 g, t dbSNP:551632669
2249 2249 c, t dbSNP:768387052
2254 2254 a, c dbSNP:533265958
2286 2286 a, c dbSNP:188772709
2293 2293 a, c dbSNP:61654202
2300 2300 c, t dbSNP:556767717
2318 2318 g, t dbSNP:146774207
2340 2340 g, t dbSNP:35447393
2356 2356 a, g dbSNP:771631125
2368 2368 c, t dbSNP:771422917
2378 2378 a, g dbSNP:116974943
2391 2391 c, t dbSNP:778803206
2392 2392 a, g dbSNP:562018552
2397 2397 a, g dbSNP:770213553
2420 2420 -, at dbSNP:758000102

Target ORF information:

RefSeq Version NM_001256317
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant F, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001256317

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGGT GACGCCTCCC CTGTCCTGAA CCACGCGGCC
GTCCCTTTGA TTTCCAACAA GATCTGCAAC CACAGGGACG TGTACGGTGG CATCATCTCC
CCCTCCATGC TCTGCGCGGG CTACCTGACG GGTGGCGTGG ACAGCTGCCA GGGGGACAGC
GGGGGGCCCC TGGTGTGTCA AGAGAGGAGG CTGTGGAAGT TAGTGGGAGC GACCAGCTTT
GGCATCGGCT GCGCAGAGGT GAACAAGCCT GGGGTGTACA CCCGTGTCAC CTCCTTCCTG
GACTGGATCC ACGAGCAGAT GGAGAGAGAC CTAAAAACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26323
Accession Version NM_024022.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1365bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protease serine 3 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB038157.1, AK172842.1 and AI251446.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2009 this sequence version replaced gi:13173470. Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (A) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB038157.1, AY633572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_076927.1
CDS202..1566
Misc Feature(1)346..408(+)
Misc Feature(2)421..522(+)
Misc Feature(3)430..495(+)
Misc Feature(4)469..513(+)
Misc Feature(5)499..513(+)
Misc Feature(6)535..834(+)
Misc Feature(7)847..1533(+)
Misc Feature(8)847..852(+)
Misc Feature(9)850..1542(+)
Misc Feature(10)850..852(+)
Misc Feature(11)970..1404(+)
Misc Feature(12)1384..1467(+)
Exon (1)1..150
Gene:TMPRSS3
Gene Synonym:
Exon (2)151..295
Gene:TMPRSS3
Gene Synonym:
Exon (3)296..406
Gene:TMPRSS3
Gene Synonym:
Exon (4)407..523
Gene:TMPRSS3
Gene Synonym:
Exon (5)524..647
Gene:TMPRSS3
Gene Synonym:
Exon (6)648..773
Gene:TMPRSS3
Gene Synonym:
Exon (7)774..817
Gene:TMPRSS3
Gene Synonym:
Exon (8)818..983
Gene:TMPRSS3
Gene Synonym:
Exon (9)984..1153
Gene:TMPRSS3
Gene Synonym:
Exon (10)1154..1249
Gene:TMPRSS3
Gene Synonym:
Exon (11)1250..1395
Gene:TMPRSS3
Gene Synonym:
Exon (12)1396..1548
Gene:TMPRSS3
Gene Synonym:
Exon (13)1549..2441
Gene:TMPRSS3
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:755944650
4 4 a, g, t dbSNP:56100074
10 10 c, t dbSNP:540503594
11 11 a, g dbSNP:754521287
13 13 a, t dbSNP:753306106
14 14 c, t dbSNP:377532101
15 15 a, g dbSNP:762360884
16 16 g, t dbSNP:752032749
19 19 a, c dbSNP:767574751
20 20 a, c, g dbSNP:147296608
27 27 c, t dbSNP:765305889
28 28 g, t dbSNP:759691958
30 30 a, g dbSNP:191054653
33 33 c, t dbSNP:56347158
37 37 a, g dbSNP:771111101
45 45 a, g dbSNP:746981844
50 50 c, t dbSNP:773269515
51 51 a, g dbSNP:771916158
55 55 a, g dbSNP:200277359
59 59 c, t dbSNP:778659792
60 60 a, c dbSNP:754542420
64 64 a, c dbSNP:748920724
66 66 c, g dbSNP:779582533
69 69 c, t dbSNP:755619879
71 71 a, c, g dbSNP:56369547
79 79 g, t dbSNP:758790604
87 87 a, g dbSNP:752961392
92 92 c, t dbSNP:765518679
93 93 a, g dbSNP:759886263
103 103 a, g dbSNP:375438526
106 106 a, g dbSNP:776962558
114 114 c, t dbSNP:766631539
115 115 a, g dbSNP:371722059
120 120 a, g dbSNP:773287558
123 123 a, g dbSNP:771866484
124 124 a, t dbSNP:557132994
129 129 a, g dbSNP:774066728
136 136 c, g dbSNP:768469011
141 141 c, t dbSNP:749010685
142 142 a, g dbSNP:779671143
148 148 c, t dbSNP:755630225
151 151 a, g dbSNP:371778905
157 157 c, g dbSNP:756454876
159 159 g, t dbSNP:750630070
161 161 g, t dbSNP:538734255
166 166 c, g dbSNP:186244930
167 167 c, g dbSNP:751468633
168 168 a, g dbSNP:73372256
173 173 c, t dbSNP:376404558
174 174 a, g dbSNP:775213790
175 175 a, g dbSNP:769552964
178 178 a, g dbSNP:759150161
180 180 c, t dbSNP:373324024
192 192 a, g dbSNP:770405018
204 204 g, t dbSNP:746461825
208 208 a, g dbSNP:779595310
212 212 a, t dbSNP:769238563
218 218 c, t dbSNP:139865555
219 219 a, g, t dbSNP:200199344
222 222 a, t dbSNP:143981919
226 226 c, g dbSNP:149481350
229 229 a, g dbSNP:781420452
233 233 a, c dbSNP:372629505
234 234 c, t dbSNP:138052370
237 237 c, t dbSNP:764038602
240 240 c, g dbSNP:150765531
242 242 c, t dbSNP:752598801
248 248 a, g, t dbSNP:369418733
251 251 a, c, t dbSNP:766015335
252 252 a, g dbSNP:182209675
253 253 a, c, t dbSNP:372359927
264 264 c, t dbSNP:749880255
266 266 a, g dbSNP:776129573
268 268 a, g dbSNP:770072040
272 272 -, t dbSNP:771977117
284 284 a, c, t dbSNP:137882698
286 286 c, g dbSNP:757448130
302 302 a, t dbSNP:142917173
318 318 g, t dbSNP:747297139
322 322 c, t dbSNP:779277523
324 324 g, t dbSNP:201147366
325 325 c, t dbSNP:758485931
334 334 c, t dbSNP:748158424
335 335 c, t dbSNP:778738918
336 336 a, g, t dbSNP:140388341
357 357 c, t dbSNP:367999701
358 358 a, g dbSNP:928302
362 362 c, t dbSNP:142317371
394 394 a, g dbSNP:374679649
409 409 -, c dbSNP:727503493
413 413 c, g, t dbSNP:185332310
414 414 c, t dbSNP:200937562
415 415 a, g dbSNP:746526904
432 432 c, t dbSNP:139934512
435 435 a, c, g dbSNP:567503320
439 439 a, c, t dbSNP:143733205
440 440 a, g, t dbSNP:146159479
443 443 c, g dbSNP:757110501
453 453 a, g dbSNP:537210157
458 458 a, t dbSNP:397517372
459 459 c, t dbSNP:192083827
467 467 c, t dbSNP:757929050
469 469 a, g dbSNP:45598239
470 470 a, c dbSNP:764704910
472 472 c, t dbSNP:199903164
473 473 a, g, t dbSNP:397517373
478 478 a, g dbSNP:762109724
480 480 c, t dbSNP:145824109
481 481 a, g dbSNP:143762350
483 483 a, g dbSNP:143130957
488 488 c, t dbSNP:201811831
489 489 a, g dbSNP:769959543
492 492 c, t dbSNP:375429122
497 497 a, g dbSNP:745864701
499 499 c, g dbSNP:397517374
501 501 c, t dbSNP:146621712
502 502 a, g dbSNP:746713644
509 509 a, g dbSNP:387906915
510 510 c, t dbSNP:111033502
511 511 a, g dbSNP:373058706
513 513 a, g dbSNP:747805672
517 517 c, t dbSNP:139805921
518 518 a, g dbSNP:200028529
526 526 c, t dbSNP:201632198
527 527 a, g dbSNP:139484231
528 528 c, g, t dbSNP:759723029
531 531 a, g dbSNP:753920908
532 532 a, g dbSNP:35227181
534 534 c, t dbSNP:397517375
539 539 a, g dbSNP:760596000
545 545 c, g dbSNP:773186208
546 546 c, g, t dbSNP:142577467
547 547 a, g dbSNP:200090033
548 548 c, t dbSNP:201007237
558 558 a, g dbSNP:748912691
565 565 a, g dbSNP:779576286
569 569 c, t dbSNP:769346020
572 572 c, t dbSNP:747531199
573 573 a, g, t dbSNP:141682398
591 591 c, t dbSNP:753073419
592 592 a, c, g dbSNP:144556872
596 596 a, g dbSNP:754081459
604 604 a, g dbSNP:769177813
606 606 a, t dbSNP:766427297
612 612 c, t dbSNP:142784113
613 613 a, g, t dbSNP:140614903
614 614 a, c dbSNP:147231991
619 619 c, g dbSNP:774177677
626 626 a, g dbSNP:763842122
628 628 g, t dbSNP:762664593
633 633 -, a dbSNP:780609668
633 633 a, g, t dbSNP:61731564
638 638 a, g dbSNP:372586986
650 650 a, g dbSNP:368884558
652 652 c, g dbSNP:187406481
653 653 a, t dbSNP:181757077
654 654 a, g dbSNP:2839501
657 657 c, t dbSNP:776255076
660 660 a, c dbSNP:766994412
662 662 a, g dbSNP:770534938
667 667 c, t dbSNP:189002288
671 671 g, t dbSNP:774941186
680 680 c, t dbSNP:769146338
681 681 a, c, g, t dbSNP:376399439
693 693 c, g dbSNP:756404398
695 695 -, c dbSNP:34332832
696 696 c, t dbSNP:746043102
697 697 c, t dbSNP:781395690
698 698 a, g, t dbSNP:150397427
709 709 c, g dbSNP:763956555
712 712 c, t dbSNP:758223685
716 716 c, t dbSNP:752489902
717 717 a, c, t dbSNP:141476064
718 718 a, c, g dbSNP:766000719
723 723 a, c dbSNP:760194949
733 733 a, g dbSNP:764627057
735 735 c, t dbSNP:775028939
741 741 a, g dbSNP:201438268
742 742 a, g, t dbSNP:148313943
752 752 c, t dbSNP:770046529
756 756 c, t dbSNP:746156374
767 767 a, t dbSNP:781338726
768 768 c, g, t dbSNP:747054153
780 780 -, a dbSNP:397517376
790 790 c, g dbSNP:145109634
794 794 a, g dbSNP:200153943
796 796 a, g dbSNP:772040483
808 808 a, c, g dbSNP:141372828
841 841 a, g dbSNP:146604336
847 847 c, t dbSNP:145913750
848 848 a, g, t dbSNP:137853000
852 852 c, t dbSNP:376455414
853 853 a, g, t dbSNP:567975394
867 867 a, g dbSNP:373261804
870 870 c, t dbSNP:369273878
878 878 c, t dbSNP:763150678
879 879 a, g dbSNP:556073981
882 882 a, g dbSNP:201260442
906 906 c, g dbSNP:202037999
909 909 c, t dbSNP:776618952
912 912 c, g dbSNP:770646507
914 914 g, t dbSNP:772728753
916 916 c, t dbSNP:149001183
927 927 c, t dbSNP:533472191
928 928 a, g dbSNP:372526764
930 930 a, g dbSNP:747767404
932 932 a, g, t dbSNP:397517377
944 944 c, t dbSNP:768140716
945 945 a, g dbSNP:369903582
946 946 c, t dbSNP:376797288
954 954 c, g dbSNP:137852999
955 955 a, g dbSNP:371345947
957 957 c, g dbSNP:542121546
958 958 a, g dbSNP:2839500
959 959 c, t dbSNP:747352986
964 964 g, t dbSNP:778263709
965 965 c, t dbSNP:758738833
984 984 c, t dbSNP:397517378
987 987 c, g dbSNP:149869600
990 990 c, t dbSNP:147181936
993 993 c, t dbSNP:576826396
995 995 a, c dbSNP:769186992
997 997 a, t dbSNP:747580775
1001 1001 c, t dbSNP:773798591
1002 1002 a, g dbSNP:147785678
1011 1011 a, c dbSNP:144303402
1012 1012 a, c dbSNP:373744270
1017 1017 a, g dbSNP:756558488
1032 1032 c, g dbSNP:140552212
1033 1033 g, t dbSNP:768961609
1046 1046 c, t dbSNP:749465715
1050 1050 a, g dbSNP:780237490
1052 1052 c, t dbSNP:371475934
1057 1057 a, t dbSNP:147189374
1058 1058 g, t dbSNP:750362044
1068 1068 g, t dbSNP:781063590
1072 1072 c, g dbSNP:757064799
1074 1074 c, t dbSNP:751401936
1082 1082 a, g dbSNP:763769638
1083 1083 -, c dbSNP:772214350
1084 1084 a, g dbSNP:762736510
1095 1095 a, c dbSNP:752283050
1101 1101 a, g dbSNP:764821256
1102 1102 c, g dbSNP:573439830
1104 1104 g, t dbSNP:759050767
1109 1109 a, g dbSNP:773886793
1110 1110 a, t dbSNP:772660950
1116 1116 a, c, t dbSNP:774844255
1117 1117 a, g dbSNP:181949335
1119 1119 c, g dbSNP:749538864
1120 1120 c, g dbSNP:780073182
1134 1134 c, t dbSNP:145235893
1135 1135 a, g dbSNP:745895791
1136 1136 g, t dbSNP:566876247
1138 1138 c, t dbSNP:781225282
1140 1140 a, t dbSNP:757228573
1145 1145 a, c, t dbSNP:777685846
1146 1146 a, g dbSNP:766662530
1149 1149 c, g dbSNP:727504592
1151 1151 a, g dbSNP:550255214
1153 1153 a, g dbSNP:752399941
1158 1158 c, g dbSNP:115223836
1159 1159 a, t dbSNP:771954317
1161 1161 c, t dbSNP:117766615
1165 1165 c, t dbSNP:778907728
1170 1170 g, t dbSNP:371149049
1174 1174 c, t dbSNP:140676332
1176 1176 g, t dbSNP:397517379
1182 1182 c, t dbSNP:755667543
1185 1185 c, t dbSNP:749947184
1193 1193 a, g dbSNP:767019311
1194 1194 c, t dbSNP:397517380
1199 1199 a, c, g, t dbSNP:144682332
1200 1200 -, c dbSNP:748150602
1200 1200 c, t dbSNP:192630206
1201 1201 a, g dbSNP:776873836
1203 1203 a, t dbSNP:376916029
1205 1205 c, g dbSNP:369161852
1209 1209 -, a dbSNP:774670393
1220 1220 c, t dbSNP:200002841
1221 1221 a, g dbSNP:374149338
1226 1226 a, g dbSNP:397517368
1227 1227 a, t dbSNP:565271986
1229 1229 g, t dbSNP:540715620
1233 1233 a, g dbSNP:774362783
1234 1234 -, g dbSNP:768759797
1234 1234 a, g dbSNP:573318480
1239 1239 a, t dbSNP:200554019
1242 1242 a, g, t dbSNP:779969755
1243 1243 a, g dbSNP:111033261
1249 1249 a, g dbSNP:377604843
1255 1255 a, g dbSNP:745522641
1256 1256 a, g dbSNP:752332652
1257 1257 c, t dbSNP:397517369
1258 1258 a, g dbSNP:188750127
1263 1263 c, g dbSNP:199751071
1275 1275 a, c dbSNP:777243740
1276 1276 c, t dbSNP:755519837
1278 1278 c, t dbSNP:754341063
1280 1280 c, t dbSNP:200777266
1281 1281 a, g dbSNP:756432794
1284 1284 c, t dbSNP:750642034
1285 1285 a, g dbSNP:767728685
1288 1288 a, c dbSNP:757529665
1291 1291 g, t dbSNP:397517370
1317 1317 c, t dbSNP:145077154
1322 1322 a, g dbSNP:764262141
1323 1323 c, t dbSNP:113747896
1324 1324 a, g dbSNP:775508015
1329 1329 c, t dbSNP:111033292
1330 1330 a, g dbSNP:371448615
1336 1336 a, g dbSNP:776173937
1337 1337 c, t dbSNP:770666997
1347 1347 c, t dbSNP:746633574
1348 1348 a, t dbSNP:772776809
1349 1349 c, t dbSNP:771559352
1352 1352 a, t dbSNP:749798053
1353 1353 g, t dbSNP:727503492
1356 1356 c, g dbSNP:780568459
1357 1357 g, t dbSNP:756455958
1359 1359 c, t dbSNP:746293388
1360 1360 a, g dbSNP:781376204
1361 1361 c, t dbSNP:201172277
1362 1362 a, c, g dbSNP:568884207
1368 1368 c, t dbSNP:758488441
1369 1369 a, c, t dbSNP:371402895
1371 1371 c, g dbSNP:374082620
1373 1373 c, t dbSNP:145766262
1374 1374 a, g dbSNP:140620963
1375 1375 a, g dbSNP:760379793
1381 1381 a, g dbSNP:151315833
1384 1384 c, g dbSNP:111033537
1388 1388 a, g dbSNP:747606494
1391 1391 g, t dbSNP:773711263
1393 1393 c, t dbSNP:727504304
1395 1395 a, g dbSNP:770372956
1397 1397 a, g dbSNP:763663882
1401 1401 c, g dbSNP:397517371
1406 1406 a, g dbSNP:777302040
1412 1412 c, t dbSNP:28939084
1414 1414 c, t dbSNP:761233720
1420 1420 c, t dbSNP:773780151
1428 1428 -, g dbSNP:780413386
1437 1437 c, g, t dbSNP:748419198
1439 1439 a, g dbSNP:778939088
1443 1443 a, g dbSNP:768801900
1454 1454 c, g, t dbSNP:377531325
1455 1455 a, g dbSNP:756106839
1458 1458 c, t dbSNP:745791794
1467 1467 c, t dbSNP:143447868
1470 1470 c, t dbSNP:372469227
1471 1471 a, g dbSNP:751253556
1476 1476 c, g, t dbSNP:56178910
1477 1477 a, g dbSNP:56264519
1483 1483 a, g dbSNP:764834949
1484 1484 g, t dbSNP:761325889
1487 1487 a, g dbSNP:144344468
1492 1492 c, t dbSNP:767931569
1494 1494 c, t dbSNP:762046668
1496 1496 c, g dbSNP:774754033
1497 1497 c, g dbSNP:369050452
1505 1505 c, t dbSNP:374775170
1507 1507 c, t dbSNP:565348874
1508 1508 a, g dbSNP:769807644
1510 1510 a, g dbSNP:114904237
1515 1515 c, t dbSNP:781065790
1536 1536 c, t dbSNP:186972955
1537 1537 a, c, g dbSNP:777595673
1539 1539 a, g dbSNP:758055060
1540 1540 c, g dbSNP:147621273
1544 1544 c, t dbSNP:201018751
1545 1545 a, g dbSNP:267606141
1564 1564 c, t dbSNP:149919890
1568 1568 a, g dbSNP:13047838
1575 1575 c, g dbSNP:376617444
1582 1582 a, g dbSNP:373631775
1588 1588 a, c dbSNP:760543023
1589 1589 c, t dbSNP:773138888
1591 1591 c, t dbSNP:772027252
1594 1594 a, g dbSNP:747907091
1600 1600 a, g dbSNP:560422036
1605 1605 a, g dbSNP:768487011
1612 1612 a, g dbSNP:748952887
1618 1618 c, t dbSNP:779440962
1619 1619 a, g dbSNP:137903612
1621 1621 a, t dbSNP:574793792
1622 1622 c, t dbSNP:562911942
1637 1637 a, c, g, t dbSNP:765583795
1638 1638 a, g dbSNP:146942080
1640 1640 a, g dbSNP:754035154
1647 1647 c, t dbSNP:766378265
1648 1648 c, g, t dbSNP:773048535
1655 1655 c, t dbSNP:772188430
1656 1656 a, g dbSNP:752845603
1657 1657 a, g dbSNP:774342587
1666 1666 c, t dbSNP:577236954
1669 1669 c, t dbSNP:748894351
1674 1674 c, t dbSNP:775167159
1679 1679 -, ag dbSNP:756407302
1684 1684 c, t dbSNP:537768966
1685 1685 a, g dbSNP:745429674
1687 1687 c, g dbSNP:780648559
1689 1689 c, t dbSNP:758971690
1690 1690 a, c, t dbSNP:779262487
1700 1700 a, c dbSNP:755304820
1702 1702 c, t dbSNP:754041925
1703 1703 a, g dbSNP:374108302
1707 1707 a, g dbSNP:756270012
1729 1729 c, t dbSNP:750580679
1732 1732 a, c dbSNP:767689219
1745 1745 a, c dbSNP:761851082
1754 1754 -, ctttttg dbSNP:746406661
1755 1755 c, t dbSNP:114813487
1757 1757 c, t dbSNP:116789917
1763 1763 c, t dbSNP:112618394
1768 1768 -, t dbSNP:781505001
1768 1768 -, t dbSNP:756840804
1772 1772 a, g dbSNP:225309
1774 1774 g, t dbSNP:775122912
1777 1777 g, t dbSNP:769525510
1779 1779 c, t dbSNP:745504094
1781 1781 c, t dbSNP:776179259
1782 1782 a, g, t dbSNP:748659120
1783 1783 c, t dbSNP:527529577
1795 1795 c, g dbSNP:779356250
1806 1806 a, g dbSNP:536353688
1811 1811 c, t dbSNP:755324540
1812 1812 a, g dbSNP:57692239
1818 1818 c, t dbSNP:377203280
1825 1825 a, c dbSNP:75706305
1830 1830 a, g dbSNP:186721880
1836 1836 -, tcc dbSNP:763182738
1836 1836 c, t dbSNP:538228372
1842 1842 c, t dbSNP:750613856
1849 1849 c, t dbSNP:767705563
1853 1853 c, t dbSNP:757369320
1864 1864 c, t dbSNP:751564896
1899 1899 c, t dbSNP:534653513
1900 1900 a, g dbSNP:182472675
1901 1901 a, c dbSNP:762767504
1917 1917 a, c dbSNP:551510160
1937 1937 a, g dbSNP:775421153
1968 1968 c, t dbSNP:764929225
1973 1973 a, t dbSNP:145515753
1975 1975 c, t dbSNP:55954914
1977 1977 a, c dbSNP:140838491
1995 1995 a, c dbSNP:760132655
2008 2008 c, t dbSNP:772690986
2021 2021 a, g dbSNP:773503618
2026 2026 c, t dbSNP:749758096
2042 2042 c, t dbSNP:555701604
2043 2043 a, g dbSNP:537211737
2046 2046 c, t dbSNP:746120755
2054 2054 c, t dbSNP:781515551
2055 2055 a, c, g dbSNP:562818521
2058 2058 c, t dbSNP:115398434
2059 2059 c, t dbSNP:146497192
2061 2061 g, t dbSNP:777709647
2073 2073 c, g dbSNP:193295918
2105 2105 c, t dbSNP:540533831
2106 2106 a, g dbSNP:144138830
2141 2141 -, g dbSNP:397867467
2144 2144 -, g dbSNP:34908991
2162 2162 c, t dbSNP:765085568
2187 2187 c, t dbSNP:554763027
2220 2220 c, t dbSNP:139451134
2230 2230 c, t dbSNP:753514974
2236 2236 g, t dbSNP:551632669
2252 2252 c, t dbSNP:768387052
2257 2257 a, c dbSNP:533265958
2289 2289 a, c dbSNP:188772709
2296 2296 a, c dbSNP:61654202
2303 2303 c, t dbSNP:556767717
2321 2321 g, t dbSNP:146774207
2343 2343 g, t dbSNP:35447393
2359 2359 a, g dbSNP:771631125
2371 2371 c, t dbSNP:771422917
2381 2381 a, g dbSNP:116974943
2394 2394 c, t dbSNP:778803206
2395 2395 a, g dbSNP:562018552
2400 2400 a, g dbSNP:770213553
2423 2423 -, at dbSNP:758000102

Target ORF information:

RefSeq Version NM_024022
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protease, serine 3 (TMPRSS3), transcript variant A, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024022

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGGGGAAA ATGATCCGCC TGCTGTTGAA GCCCCCTTCT CATTCCGATC GCTTTTTGGC 
CTTGATGATT TGAAAATAAG TCCTGTTGCA CCAGATGCAG ATGCTGTTGC TGCACAGATC
CTGTCACTGC TGCCATTGAA GTTTTTTCCA ATCATCGTCA TTGGGATCAT TGCATTGATA
TTAGCACTGG CCATTGGTCT GGGCATCCAC TTCGACTGCT CAGGGAAGTA CAGATGTCGC
TCATCCTTTA AGTGTATCGA GCTGATAGCT CGATGTGACG GAGTCTCGGA TTGCAAAGAC
GGGGAGGACG AGTACCGCTG TGTCCGGGTG GGTGGTCAGA ATGCCGTGCT CCAGGTGTTC
ACAGCTGCTT CGTGGAAGAC CATGTGCTCC GATGACTGGA AGGGTCACTA CGCAAATGTT
GCCTGTGCCC AACTGGGTTT CCCAAGCTAT GTGAGTTCAG ATAACCTCAG AGTGAGCTCG
CTGGAGGGGC AGTTCCGGGA GGAGTTTGTG TCCATCGATC ACCTCTTGCC AGATGACAAG
GTGACTGCAT TACACCACTC AGTATATGTG AGGGAGGGAT GTGCCTCTGG CCACGTGGTT
ACCTTGCAGT GCACAGCCTG TGGTCATAGA AGGGGCTACA GCTCACGCAT CGTGGGTGGA
AACATGTCCT TGCTCTCGCA GTGGCCCTGG CAGGCCAGCC TTCAGTTCCA GGGCTACCAC
CTGTGCGGGG GCTCTGTCAT CACGCCCCTG TGGATCATCA CTGCTGCACA CTGTGTTTAT
GACTTGTACC TCCCCAAGTC ATGGACCATC CAGGTGGGTC TAGTTTCCCT GTTGGACAAT
CCAGCCCCAT CCCACTTGGT GGAGAAGATT GTCTACCACA GCAAGTACAA GCCAAAGAGG
CTGGGCAATG ACATCGCCCT TATGAAGCTG GCCGGGCCAC TCACGTTCAA TGAAATGATC
CAGCCTGTGT GCCTGCCCAA CTCTGAAGAG AACTTCCCCG ATGGAAAAGT GTGCTGGACG
TCAGGATGGG GGGCCACAGA GGATGGAGCA GGTGACGCCT CCCCTGTCCT GAACCACGCG
GCCGTCCCTT TGATTTCCAA CAAGATCTGC AACCACAGGG ACGTGTACGG TGGCATCATC
TCCCCCTCCA TGCTCTGCGC GGGCTACCTG ACGGGTGGCG TGGACAGCTG CCAGGGGGAC
AGCGGGGGGC CCCTGGTGTG TCAAGAGAGG AGGCTGTGGA AGTTAGTGGG AGCGACCAGC
TTTGGCATCG GCTGCGCAGA GGTGAACAAG CCTGGGGTGT ACACCCGTGT CACCTCCTTC
CTGGACTGGA TCCACGAGCA GATGGAGAGA GACCTAAAAA CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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