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SHOX short stature homeobox [Homo sapiens (human)]

Gene Symbol SHOX
Entrez Gene ID 6473
Full Name short stature homeobox
Synonyms GCFX, PHOG, SHOXY, SS
General protein information
Preferred Names
short stature homeobox protein
Names
short stature homeobox protein
growth control factor, X-linked
pseudoautosomal homeobox-containing osteogenic protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X|Y

Xp22.33;Yp11.3

Summary This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

400020

Disorder Html: Short stature, idiopathic familial, 300582 (3); Leri-Weill





The following SHOX gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SHOX gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22956 NM_000451 Homo sapiens short stature homeobox (SHOX), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.3
$309
OHu23147 NM_006883 Homo sapiens short stature homeobox (SHOX), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $269

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu22956
Accession Version NM_000451.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 879bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product short stature homeobox protein isoform SHOXa
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX004827.19. This sequence is a reference standard in the RefSeqGene project. On Mar 8, 2006 this sequence version replaced gi:6031201. Summary: This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (SHOXa). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: U89331.1, Y11536.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2150585 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAAGAGC TCACGGCTTT TGTATCCAAG TCTTTTGACC AGAAAAGCAA GGACGGTAAC 
GGCGGAGGCG GAGGCGGCGG AGGTAAGAAG GATTCCATTA CGTACCGGGA AGTTTTGGAG
AGCGGACTGG CGCGCTCCCG GGAGCTGGGG ACGTCGGATT CCAGCCTCCA GGACATCACG
GAGGGCGGCG GCCACTGCCC GGTGCATTTG TTCAAGGACC ACGTAGACAA TGACAAGGAG
AAACTGAAAG AATTCGGCAC CGCGAGAGTG GCAGAAGGGA TTTATGAATG CAAAGAGAAG
CGCGAGGACG TGAAGTCGGA GGACGAGGAC GGGCAGACCA AGCTGAAACA GAGGCGCAGC
CGCACCAACT TCACGCTGGA GCAGCTGAAC GAGCTCGAGC GACTCTTCGA CGAGACCCAT
TACCCCGACG CCTTCATGCG CGAGGAGCTC AGCCAGCGCC TGGGGCTCTC CGAGGCGCGC
GTGCAGGTTT GGTTCCAGAA CCGGAGAGCC AAGTGCCGCA AACAAGAGAA TCAGATGCAT
AAAGGCGTCA TCTTGGGCAC AGCCAACCAC CTAGACGCCT GCCGAGTGGC ACCCTACGTC
AACATGGGAG CCTTACGGAT GCCTTTCCAA CAGGTCCAGG CTCAGCTGCA GCTGGAAGGC
GTGGCCCACG CGCACCCGCA CCTGCACCCG CACCTGGCGG CGCACGCGCC CTACCTGATG
TTCCCCCCGC CGCCCTTCGG GCTGCCCATC GCGTCGCTGG CCGAGTCCGC CTCGGCCGCC
GCCGTGGTCG CCGCCGCCGC CAAAAGCAAC AGCAAGAATT CCAGCATCGC CGACCTGCGG
CTCAAGGCGC GGAAGCACGC GGAGGCCCTG GGGCTCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000442.1
CDS692..1570
Misc Feature(1)602..604(+)
Misc Feature(2)1007..1009(+)
Misc Feature(3)1043..1219(+)
Misc Feature(4)1043..1213(+)
Misc Feature(5)1049..1201(+)
Misc Feature(6)1415..1438(+)
Misc Feature(7)1496..1558(+)
Misc Feature(8)1511..1552(+)
Exon (1)1..259
Gene:SHOX
Gene Synonym:
Exon (2)260..968
Gene:SHOX
Gene Synonym:
Exon (3)969..1177
Gene:SHOX
Gene Synonym:
Exon (4)1178..1235
Gene:SHOX
Gene Synonym:
Exon (5)1236..1324
Gene:SHOX
Gene Synonym:
Exon (6)1325..3757
Gene:SHOX
Gene Synonym:
Translation
Position Chain Variation Link
6 6 c, g dbSNP:28475683
12 12 g, t dbSNP:3813940
16 16 a, g dbSNP:374378100
27 27 a, g dbSNP:751766561
43 43 -, t, tt dbSNP:112273183
44 44 -, ttg dbSNP:200223988
44 44 -, t dbSNP:761645160
45 45 -, tg dbSNP:68102883
46 46 -, g dbSNP:199946685
47 47 g, t dbSNP:200022908
56 56 -, t dbSNP:55872554
87 87 c, t dbSNP:750146845
123 123 c, g dbSNP:540696315
176 176 g, t dbSNP:779801180
180 180 a, c dbSNP:113313554
185 185 c, g dbSNP:111549748
187 187 c, t dbSNP:185642798
197 197 g, t dbSNP:747768294
206 206 a, g dbSNP:771808079
209 209 a, t dbSNP:781635351
216 216 a, g dbSNP:559215064
231 231 a, g dbSNP:371510416
239 239 g, t dbSNP:770337925
278 278 c, t dbSNP:182995615
285 285 a, g dbSNP:759928739
320 320 a, g dbSNP:2239401
339 339 a, c dbSNP:753229661
349 349 a, g dbSNP:534289758
365 365 a, g dbSNP:758785061
372 372 a, g dbSNP:764305289
379 379 g, t dbSNP:187326087
449 449 a, g dbSNP:191787445
493 493 a, g dbSNP:781552450
518 518 a, g dbSNP:745718793
535 535 a, g dbSNP:755908827
543 543 a, g dbSNP:779903554
548 548 c, t dbSNP:749268122
554 554 g, t dbSNP:375938368
599 599 g, t dbSNP:768540071
609 609 c, g dbSNP:773855244
611 611 c, t dbSNP:747596021
620 620 g, t dbSNP:771765853
637 637 c, t dbSNP:772910213
638 638 c, g dbSNP:759855922
644 644 a, t dbSNP:368712281
647 647 c, g dbSNP:745475312
653 653 c, t dbSNP:765660296
660 660 g, t dbSNP:775284196
661 661 a, c, g, t dbSNP:746800766
662 662 c, g dbSNP:775680941
663 663 c, t dbSNP:766436886
664 664 c, t dbSNP:774312141
673 673 a, c, g dbSNP:201157428
678 678 c, t dbSNP:753028456
679 679 c, t dbSNP:756526396
680 680 c, t dbSNP:764591603
682 682 c, g, t dbSNP:754355154
682 682 -, g dbSNP:778186580
690 690 a, c dbSNP:778428634
717 717 a, c dbSNP:745371572
727 727 c, t dbSNP:376369288
730 730 c, t dbSNP:757990148
738 738 a, g dbSNP:779557567
742 742 a, g dbSNP:746710945
744 744 a, g dbSNP:768402466
745 745 c, t dbSNP:368409954
747 747 a, g, t dbSNP:748023493
752 752 -, ggcgga dbSNP:747349135
752 752 a, g dbSNP:773266910
754 754 c, t dbSNP:142306835
756 756 c, g dbSNP:767687473
760 760 a, c dbSNP:775822599
761 761 a, g dbSNP:761008675
767 767 -, ggcggaggt dbSNP:771317209
776 776 -, aag dbSNP:776789883
777 777 a, c dbSNP:146304983
787 787 c, t dbSNP:374590634
792 792 c, g dbSNP:751747648
797 797 c, t dbSNP:757408441
798 798 a, g dbSNP:757712337
800 800 a, g dbSNP:765654795
808 808 a, g dbSNP:267606477
811 811 a, g dbSNP:139059497
814 814 c, t dbSNP:140473647
822 822 a, c dbSNP:779647794
825 825 g, t dbSNP:751167018
826 826 c, t dbSNP:754642340
835 835 a, g dbSNP:750638027
838 838 a, g dbSNP:747933287
844 844 g, t dbSNP:769689283
848 848 c, g dbSNP:777550538
859 859 c, t dbSNP:756239303
861 861 a, g dbSNP:150426690
874 874 a, g dbSNP:775732794
878 878 a, g dbSNP:138243769
881 881 c, g dbSNP:371578837
886 886 a, c dbSNP:777056573
890 890 c, t dbSNP:200663078
891 891 c, g dbSNP:765679079
892 892 a, c, g dbSNP:753509357
895 895 a, g dbSNP:754919610
896 896 c, t dbSNP:751077122
902 902 c, t dbSNP:375027970
903 903 c, t dbSNP:754554221
904 904 c, t dbSNP:780809993
905 905 a, g dbSNP:778804130
907 907 a, g dbSNP:747720453
917 917 -, gacaat dbSNP:770050685
922 922 c, t dbSNP:752444811
936 936 c, t dbSNP:755835580
947 947 a, c, g dbSNP:777653076
949 949 a, c dbSNP:770914372
951 951 c, t dbSNP:780215482
952 952 c, g dbSNP:368925113
953 953 g, t dbSNP:747077800
958 958 a, c dbSNP:768911508
969 969 c, g dbSNP:746224384
970 970 g, t dbSNP:193922465
971 971 a, t dbSNP:780588714
985 985 a, g dbSNP:747510583
986 986 c, g dbSNP:768170715
988 988 c, g dbSNP:776301574
992 992 c, t dbSNP:761493152
993 993 a, g dbSNP:758706054
995 995 g, t dbSNP:137852558
1000 1000 c, g dbSNP:773058151
1003 1003 g, t dbSNP:762820252
1008 1008 c, g dbSNP:199774904
1016 1016 a, c, g dbSNP:202119896
1018 1018 a, g, t dbSNP:746842667
1022 1022 c, g dbSNP:764179159
1023 1023 c, g dbSNP:753917136
1026 1026 a, c dbSNP:757391565
1027 1027 c, g dbSNP:779090116
1028 1028 a, g dbSNP:750688301
1029 1029 a, c dbSNP:758757973
1031 1031 a, g dbSNP:200593538
1038 1038 a, g dbSNP:193922466
1044 1044 a, c, g dbSNP:747499580
1045 1045 a, g dbSNP:781781837
1054 1054 a, c, t dbSNP:149609259
1056 1056 c, g dbSNP:772968320
1057 1057 c, t dbSNP:762549263
1081 1081 c, g dbSNP:770714249
1084 1084 c, g dbSNP:374188319
1085 1085 c, g dbSNP:137852554
1087 1087 c, g dbSNP:759454668
1088 1088 c, g dbSNP:767349016
1091 1091 a, c dbSNP:193922467
1100 1100 g, t dbSNP:761855403
1102 1102 c, g dbSNP:367787242
1105 1105 c, g dbSNP:750602920
1107 1107 c, t dbSNP:758570651
1111 1111 c, t dbSNP:780800997
1117 1117 a, c, g dbSNP:143360725
1120 1120 c, t dbSNP:781759203
1121 1121 c, g dbSNP:748705087
1124 1124 c, t dbSNP:755649879
1127 1127 a, t dbSNP:777451265
1128 1128 c, t dbSNP:532052827
1132 1132 c, g, t dbSNP:769555283
1138 1138 a, g dbSNP:371433978
1144 1144 c, t dbSNP:771899017
1147 1147 a, g dbSNP:775371500
1149 1149 g, t dbSNP:137852555
1153 1153 a, g dbSNP:760637285
1154 1154 c, g dbSNP:765251991
1156 1156 a, g dbSNP:773177314
1162 1162 c, g, t dbSNP:774997125
1166 1166 a, g dbSNP:751858866
1168 1168 a, g dbSNP:755267491
1169 1169 c, t dbSNP:768025022
1193 1193 c, t dbSNP:137852557
1195 1195 a, g dbSNP:367892499
1199 1199 c, g dbSNP:397514461
1200 1200 a, c dbSNP:397514462
1207 1207 c, t dbSNP:779755097
1208 1208 c, t dbSNP:137852556
1209 1209 a, g dbSNP:746801054
1219 1219 g, t dbSNP:778921118
1225 1225 c, g dbSNP:748251503
1226 1226 a, t dbSNP:748149272
1229 1229 c, t dbSNP:371772960
1231 1231 c, t dbSNP:774506816
1233 1233 a, c dbSNP:759770015
1234 1234 a, c dbSNP:202144835
1237 1237 c, g, t dbSNP:138998412
1238 1238 a, g, t dbSNP:752189039
1241 1241 a, g dbSNP:754674232
1244 1244 c, t dbSNP:767154508
1250 1250 a, g dbSNP:752536855
1261 1261 c, t dbSNP:755922072
1262 1262 c, t dbSNP:777833682
1267 1267 c, t dbSNP:200088460
1268 1268 a, g dbSNP:376330042
1274 1274 a, c, t dbSNP:137852552
1275 1275 a, g dbSNP:188370909
1285 1285 c, t dbSNP:776783747
1288 1288 c, g, t dbSNP:137852553
1289 1289 a, g dbSNP:371048081
1296 1296 g, t dbSNP:773671345
1302 1302 c, t dbSNP:763473105
1305 1305 c, t dbSNP:765818786
1307 1307 c, t dbSNP:773859404
1308 1308 a, g dbSNP:759039782
1332 1332 c, t dbSNP:760264969
1352 1352 g, t dbSNP:763919225
1366 1366 c, t dbSNP:753687171
1367 1367 c, g dbSNP:761766955
1388 1388 a, g dbSNP:765253480
1389 1389 c, t dbSNP:750375727
1393 1393 a, g dbSNP:576542942
1395 1395 a, g dbSNP:781156315
1412 1412 a, c, t dbSNP:752020837
1413 1413 -, c dbSNP:757845999
1415 1415 a, c dbSNP:778039535
1418 1418 c, g, t dbSNP:374024890
1429 1429 c, t dbSNP:771336598
1432 1432 a, g dbSNP:779446897
1443 1443 a, c dbSNP:746390527
1447 1447 a, g dbSNP:771558664
1453 1453 a, c dbSNP:774871453
1461 1461 c, t dbSNP:760304872
1468 1468 a, c dbSNP:757719614
1507 1507 a, g dbSNP:776482037
1520 1520 a, g dbSNP:398123403
1555 1555 a, g dbSNP:781656634
1561 1561 a, g dbSNP:746391025
1567 1567 c, g dbSNP:750326508
1568 1568 c, t dbSNP:137852559
1574 1574 a, g dbSNP:762812932
1576 1576 c, t dbSNP:767569050
1577 1577 c, g dbSNP:752716320
1588 1588 a, c, t dbSNP:770319928
1604 1604 c, g dbSNP:370621168
1608 1608 a, c dbSNP:780063150
1611 1611 a, c dbSNP:749355015
1621 1621 a, g dbSNP:768806888
1639 1639 c, g dbSNP:774575867
1641 1641 a, c dbSNP:375374324
1675 1675 a, c dbSNP:761980134
1728 1728 c, t dbSNP:376784254
1747 1747 c, g dbSNP:181472527
1748 1748 c, g dbSNP:186114414
1822 1822 a, c dbSNP:191075100
1835 1835 c, t dbSNP:766338429
1853 1853 -, ag dbSNP:769545476
1855 1855 -, ag dbSNP:369390009
1869 1869 c, t dbSNP:759065846
1883 1883 c, t dbSNP:183343658
1894 1894 a, c dbSNP:185857936
1905 1905 a, g dbSNP:145195781
1959 1959 c, t dbSNP:768051429
1996 1996 c, t dbSNP:149127363
2014 2014 c, t dbSNP:756617334
2018 2018 c, t dbSNP:200956752
2048 2048 a, g dbSNP:780586554
2072 2072 c, g dbSNP:377561273
2108 2108 a, c dbSNP:749707006
2118 2118 -, c dbSNP:755112840
2143 2143 a, g dbSNP:778893865
2155 2155 c, g dbSNP:191201624
2164 2164 a, c dbSNP:143310175
2187 2187 c, g dbSNP:773059985
2297 2297 c, t dbSNP:746790497
2315 2315 c, t dbSNP:373739141
2323 2323 -, tattttttt dbSNP:770824104
2323 2323 -, tatttttt dbSNP:745988159
2324 2324 a, t dbSNP:73607276
2351 2351 c, t dbSNP:201738295
2380 2380 c, g dbSNP:776655485
2392 2392 a, g dbSNP:759351353
2489 2489 -, a dbSNP:200764444
2524 2524 a, g dbSNP:35507574
2526 2526 a, g dbSNP:762760194
2544 2544 a, g dbSNP:183196814
2554 2554 c, g dbSNP:145776742
2598 2598 c, t dbSNP:373715225
2669 2669 c, t dbSNP:187560973
2677 2677 a, c dbSNP:562545437
2688 2688 c, g dbSNP:766609985
2705 2705 c, t dbSNP:754370301
2721 2721 g, t dbSNP:192502886
2727 2727 g, t dbSNP:138395282
2755 2755 a, g dbSNP:748225826
2765 2765 a, g dbSNP:182779829
2807 2807 c, t dbSNP:187431074
2811 2811 a, g dbSNP:142012002
2842 2842 c, t dbSNP:150682919
2869 2869 c, t dbSNP:192656237
2870 2870 a, g dbSNP:776223317
2887 2887 a, g dbSNP:745874680
2891 2891 c, t dbSNP:184999202
2898 2898 a, t dbSNP:775178404
2916 2916 c, t dbSNP:762529345
2917 2917 a, g dbSNP:137953086
2923 2923 c, t dbSNP:774082578
2926 2926 a, g dbSNP:761300835
2931 2931 a, c dbSNP:766776146
2934 2934 c, g dbSNP:754143955
2935 2935 a, t dbSNP:760107694
2951 2951 c, t dbSNP:765704575
2988 2988 c, g dbSNP:189162461
2991 2991 c, t dbSNP:192799164
3006 3006 a, g dbSNP:777677006
3020 3020 c, t dbSNP:751811768
3035 3035 c, t dbSNP:183833394
3049 3049 c, g dbSNP:149457161
3051 3051 c, t dbSNP:745618546
3078 3078 c, t dbSNP:368319597
3094 3094 c, t dbSNP:111719077
3130 3130 -, gtc dbSNP:749194211
3133 3133 a, g dbSNP:189290967
3162 3162 c, t dbSNP:773672602
3191 3191 g, t dbSNP:761581930
3202 3202 c, t dbSNP:771623192
3210 3210 a, g dbSNP:181993811
3220 3220 c, g dbSNP:185971755
3263 3263 c, t dbSNP:552622151
3274 3274 c, t dbSNP:765540701
3471 3471 -, a dbSNP:766902053
3472 3472 -, a dbSNP:763383645
3482 3482 -, ac dbSNP:764248435
3501 3501 c, t dbSNP:751585595
3527 3527 c, g dbSNP:111339776
3541 3541 a, c dbSNP:781246972
3556 3556 c, t dbSNP:144271137
3568 3568 c, g dbSNP:756001928
3616 3616 a, t dbSNP:779925160
3625 3625 c, g dbSNP:749247044
3633 3633 c, t dbSNP:147410605
3634 3634 a, g dbSNP:778555591
3646 3646 c, t dbSNP:747584370
3647 3647 a, g dbSNP:148442993
3670 3670 a, g dbSNP:142700360
3705 3705 c, t dbSNP:772764911
3713 3713 c, t dbSNP:28410756
3727 3727 -, t dbSNP:201606123
3730 3730 a, t dbSNP:36064730
3731 3731 a, t dbSNP:775774297
3738 3738 -, agag, g, gag dbSNP:768145272
3739 3739 -, g dbSNP:764476154
3740 3740 -, g dbSNP:774539417
3740 3740 a, g dbSNP:28505100

Target ORF information:

RefSeq Version NM_000451
Organism Homo sapiens (human)
Definition Homo sapiens short stature homeobox (SHOX), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000451

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAAGAGC TCACGGCTTT TGTATCCAAG TCTTTTGACC AGAAAAGCAA GGACGGTAAC 
GGCGGAGGCG GAGGCGGCGG AGGTAAGAAG GATTCCATTA CGTACCGGGA AGTTTTGGAG
AGCGGACTGG CGCGCTCCCG GGAGCTGGGG ACGTCGGATT CCAGCCTCCA GGACATCACG
GAGGGCGGCG GCCACTGCCC GGTGCATTTG TTCAAGGACC ACGTAGACAA TGACAAGGAG
AAACTGAAAG AATTCGGCAC CGCGAGAGTG GCAGAAGGGA TTTATGAATG CAAAGAGAAG
CGCGAGGACG TGAAGTCGGA GGACGAGGAC GGGCAGACCA AGCTGAAACA GAGGCGCAGC
CGCACCAACT TCACGCTGGA GCAGCTGAAC GAGCTCGAGC GACTCTTCGA CGAGACCCAT
TACCCCGACG CCTTCATGCG CGAGGAGCTC AGCCAGCGCC TGGGGCTCTC CGAGGCGCGC
GTGCAGGTTT GGTTCCAGAA CCGGAGAGCC AAGTGCCGCA AACAAGAGAA TCAGATGCAT
AAAGGCGTCA TCTTGGGCAC AGCCAACCAC CTAGACGCCT GCCGAGTGGC ACCCTACGTC
AACATGGGAG CCTTACGGAT GCCTTTCCAA CAGGTCCAGG CTCAGCTGCA GCTGGAAGGC
GTGGCCCACG CGCACCCGCA CCTGCACCCG CACCTGGCGG CGCACGCGCC CTACCTGATG
TTCCCCCCGC CGCCCTTCGG GCTGCCCATC GCGTCGCTGG CCGAGTCCGC CTCGGCCGCC
GCCGTGGTCG CCGCCGCCGC CAAAAGCAAC AGCAAGAATT CCAGCATCGC CGACCTGCGG
CTCAAGGCGC GGAAGCACGC GGAGGCCCTG GGGCTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23147
Accession Version NM_006883.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 678bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product short stature homeobox protein isoform SHOXb
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX004827.19. This sequence is a reference standard in the RefSeqGene project. On Mar 8, 2006 this sequence version replaced gi:6031202. Summary: This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to transcript variant 1, and encodes a shorter isoform (SHOXb) with a different C-terminus compared to isoform SHOXa. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: Y11535.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA962332 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAAGAGC TCACGGCTTT TGTATCCAAG TCTTTTGACC AGAAAAGCAA GGACGGTAAC 
GGCGGAGGCG GAGGCGGCGG AGGTAAGAAG GATTCCATTA CGTACCGGGA AGTTTTGGAG
AGCGGACTGG CGCGCTCCCG GGAGCTGGGG ACGTCGGATT CCAGCCTCCA GGACATCACG
GAGGGCGGCG GCCACTGCCC GGTGCATTTG TTCAAGGACC ACGTAGACAA TGACAAGGAG
AAACTGAAAG AATTCGGCAC CGCGAGAGTG GCAGAAGGGA TTTATGAATG CAAAGAGAAG
CGCGAGGACG TGAAGTCGGA GGACGAGGAC GGGCAGACCA AGCTGAAACA GAGGCGCAGC
CGCACCAACT TCACGCTGGA GCAGCTGAAC GAGCTCGAGC GACTCTTCGA CGAGACCCAT
TACCCCGACG CCTTCATGCG CGAGGAGCTC AGCCAGCGCC TGGGGCTCTC CGAGGCGCGC
GTGCAGGTTT GGTTCCAGAA CCGGAGAGCC AAGTGCCGCA AACAAGAGAA TCAGATGCAT
AAAGGCGTCA TCTTGGGCAC AGCCAACCAC CTAGACGCCT GCCGAGTGGC ACCCTACGTC
AACATGGGAG CCTTACGGAT GCCTTTCCAA CAGATGGAGT TTTGCTCTTG TCGCCCGGGC
TGGAGTATAA TGGCATGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_006874.1
CDS692..1369
Misc Feature(1)602..604(+)
Misc Feature(2)1007..1009(+)
Misc Feature(3)1043..1219(+)
Misc Feature(4)1043..1213(+)
Misc Feature(5)1049..1201(+)
Exon (1)1..259
Gene:SHOX
Gene Synonym:
Exon (2)260..968
Gene:SHOX
Gene Synonym:
Exon (3)969..1177
Gene:SHOX
Gene Synonym:
Exon (4)1178..1235
Gene:SHOX
Gene Synonym:
Exon (5)1236..1324
Gene:SHOX
Gene Synonym:
Exon (6)1325..1951
Gene:SHOX
Gene Synonym:
Translation
Position Chain Variation Link
6 6 c, g dbSNP:28475683
12 12 g, t dbSNP:3813940
16 16 a, g dbSNP:374378100
27 27 a, g dbSNP:751766561
43 43 -, t, tt dbSNP:112273183
44 44 -, ttg dbSNP:200223988
44 44 -, t dbSNP:761645160
45 45 -, tg dbSNP:68102883
46 46 -, g dbSNP:199946685
47 47 g, t dbSNP:200022908
56 56 -, t dbSNP:55872554
87 87 c, t dbSNP:750146845
123 123 c, g dbSNP:540696315
176 176 g, t dbSNP:779801180
180 180 a, c dbSNP:113313554
185 185 c, g dbSNP:111549748
187 187 c, t dbSNP:185642798
197 197 g, t dbSNP:747768294
206 206 a, g dbSNP:771808079
209 209 a, t dbSNP:781635351
216 216 a, g dbSNP:559215064
231 231 a, g dbSNP:371510416
239 239 g, t dbSNP:770337925
278 278 c, t dbSNP:182995615
285 285 a, g dbSNP:759928739
320 320 a, g dbSNP:2239401
339 339 a, c dbSNP:753229661
349 349 a, g dbSNP:534289758
365 365 a, g dbSNP:758785061
372 372 a, g dbSNP:764305289
379 379 g, t dbSNP:187326087
449 449 a, g dbSNP:191787445
493 493 a, g dbSNP:781552450
518 518 a, g dbSNP:745718793
535 535 a, g dbSNP:755908827
543 543 a, g dbSNP:779903554
548 548 c, t dbSNP:749268122
554 554 g, t dbSNP:375938368
599 599 g, t dbSNP:768540071
609 609 c, g dbSNP:773855244
611 611 c, t dbSNP:747596021
620 620 g, t dbSNP:771765853
637 637 c, t dbSNP:772910213
638 638 c, g dbSNP:759855922
644 644 a, t dbSNP:368712281
647 647 c, g dbSNP:745475312
653 653 c, t dbSNP:765660296
660 660 g, t dbSNP:775284196
661 661 a, c, g, t dbSNP:746800766
662 662 c, g dbSNP:775680941
663 663 c, t dbSNP:766436886
664 664 c, t dbSNP:774312141
673 673 a, c, g dbSNP:201157428
678 678 c, t dbSNP:753028456
679 679 c, t dbSNP:756526396
680 680 c, t dbSNP:764591603
682 682 c, g, t dbSNP:754355154
682 682 -, g dbSNP:778186580
690 690 a, c dbSNP:778428634
717 717 a, c dbSNP:745371572
727 727 c, t dbSNP:376369288
730 730 c, t dbSNP:757990148
738 738 a, g dbSNP:779557567
742 742 a, g dbSNP:746710945
744 744 a, g dbSNP:768402466
745 745 c, t dbSNP:368409954
747 747 a, g, t dbSNP:748023493
752 752 -, ggcgga dbSNP:747349135
752 752 a, g dbSNP:773266910
754 754 c, t dbSNP:142306835
756 756 c, g dbSNP:767687473
760 760 a, c dbSNP:775822599
761 761 a, g dbSNP:761008675
767 767 -, ggcggaggt dbSNP:771317209
776 776 -, aag dbSNP:776789883
777 777 a, c dbSNP:146304983
787 787 c, t dbSNP:374590634
792 792 c, g dbSNP:751747648
797 797 c, t dbSNP:757408441
798 798 a, g dbSNP:757712337
800 800 a, g dbSNP:765654795
808 808 a, g dbSNP:267606477
811 811 a, g dbSNP:139059497
814 814 c, t dbSNP:140473647
822 822 a, c dbSNP:779647794
825 825 g, t dbSNP:751167018
826 826 c, t dbSNP:754642340
835 835 a, g dbSNP:750638027
838 838 a, g dbSNP:747933287
844 844 g, t dbSNP:769689283
848 848 c, g dbSNP:777550538
859 859 c, t dbSNP:756239303
861 861 a, g dbSNP:150426690
874 874 a, g dbSNP:775732794
878 878 a, g dbSNP:138243769
881 881 c, g dbSNP:371578837
886 886 a, c dbSNP:777056573
890 890 c, t dbSNP:200663078
891 891 c, g dbSNP:765679079
892 892 a, c, g dbSNP:753509357
895 895 a, g dbSNP:754919610
896 896 c, t dbSNP:751077122
902 902 c, t dbSNP:375027970
903 903 c, t dbSNP:754554221
904 904 c, t dbSNP:780809993
905 905 a, g dbSNP:778804130
907 907 a, g dbSNP:747720453
917 917 -, gacaat dbSNP:770050685
922 922 c, t dbSNP:752444811
936 936 c, t dbSNP:755835580
947 947 a, c, g dbSNP:777653076
949 949 a, c dbSNP:770914372
951 951 c, t dbSNP:780215482
952 952 c, g dbSNP:368925113
953 953 g, t dbSNP:747077800
958 958 a, c dbSNP:768911508
969 969 c, g dbSNP:746224384
970 970 g, t dbSNP:193922465
971 971 a, t dbSNP:780588714
985 985 a, g dbSNP:747510583
986 986 c, g dbSNP:768170715
988 988 c, g dbSNP:776301574
992 992 c, t dbSNP:761493152
993 993 a, g dbSNP:758706054
995 995 g, t dbSNP:137852558
1000 1000 c, g dbSNP:773058151
1003 1003 g, t dbSNP:762820252
1008 1008 c, g dbSNP:199774904
1016 1016 a, c, g dbSNP:202119896
1018 1018 a, g, t dbSNP:746842667
1022 1022 c, g dbSNP:764179159
1023 1023 c, g dbSNP:753917136
1026 1026 a, c dbSNP:757391565
1027 1027 c, g dbSNP:779090116
1028 1028 a, g dbSNP:750688301
1029 1029 a, c dbSNP:758757973
1031 1031 a, g dbSNP:200593538
1038 1038 a, g dbSNP:193922466
1044 1044 a, c, g dbSNP:747499580
1045 1045 a, g dbSNP:781781837
1054 1054 a, c, t dbSNP:149609259
1056 1056 c, g dbSNP:772968320
1057 1057 c, t dbSNP:762549263
1081 1081 c, g dbSNP:770714249
1084 1084 c, g dbSNP:374188319
1085 1085 c, g dbSNP:137852554
1087 1087 c, g dbSNP:759454668
1088 1088 c, g dbSNP:767349016
1091 1091 a, c dbSNP:193922467
1100 1100 g, t dbSNP:761855403
1102 1102 c, g dbSNP:367787242
1105 1105 c, g dbSNP:750602920
1107 1107 c, t dbSNP:758570651
1111 1111 c, t dbSNP:780800997
1117 1117 a, c, g dbSNP:143360725
1120 1120 c, t dbSNP:781759203
1121 1121 c, g dbSNP:748705087
1124 1124 c, t dbSNP:755649879
1127 1127 a, t dbSNP:777451265
1128 1128 c, t dbSNP:532052827
1132 1132 c, g, t dbSNP:769555283
1138 1138 a, g dbSNP:371433978
1144 1144 c, t dbSNP:771899017
1147 1147 a, g dbSNP:775371500
1149 1149 g, t dbSNP:137852555
1153 1153 a, g dbSNP:760637285
1154 1154 c, g dbSNP:765251991
1156 1156 a, g dbSNP:773177314
1162 1162 c, g, t dbSNP:774997125
1166 1166 a, g dbSNP:751858866
1168 1168 a, g dbSNP:755267491
1169 1169 c, t dbSNP:768025022
1193 1193 c, t dbSNP:137852557
1195 1195 a, g dbSNP:367892499
1199 1199 c, g dbSNP:397514461
1200 1200 a, c dbSNP:397514462
1207 1207 c, t dbSNP:779755097
1208 1208 c, t dbSNP:137852556
1209 1209 a, g dbSNP:746801054
1219 1219 g, t dbSNP:778921118
1225 1225 c, g dbSNP:748251503
1226 1226 a, t dbSNP:748149272
1229 1229 c, t dbSNP:371772960
1231 1231 c, t dbSNP:774506816
1233 1233 a, c dbSNP:759770015
1234 1234 a, c dbSNP:202144835
1237 1237 c, g, t dbSNP:138998412
1238 1238 a, g, t dbSNP:752189039
1241 1241 a, g dbSNP:754674232
1244 1244 c, t dbSNP:767154508
1250 1250 a, g dbSNP:752536855
1261 1261 c, t dbSNP:755922072
1262 1262 c, t dbSNP:777833682
1267 1267 c, t dbSNP:200088460
1268 1268 a, g dbSNP:376330042
1274 1274 a, c, t dbSNP:137852552
1275 1275 a, g dbSNP:188370909
1285 1285 c, t dbSNP:776783747
1288 1288 c, g, t dbSNP:137852553
1289 1289 a, g dbSNP:371048081
1296 1296 g, t dbSNP:773671345
1302 1302 c, t dbSNP:763473105
1305 1305 c, t dbSNP:765818786
1307 1307 c, t dbSNP:773859404
1308 1308 a, g dbSNP:759039782
1325 1325 a, t dbSNP:766798229
1343 1343 c, t dbSNP:761462186
1344 1344 a, g dbSNP:193072890
1348 1348 a, g, t dbSNP:28474801
1350 1350 g, t dbSNP:755702135
1358 1358 a, g dbSNP:755661137
1359 1359 c, t dbSNP:765859856
1361 1361 a, g dbSNP:753553503
1366 1366 a, g dbSNP:754593305
1367 1367 c, t dbSNP:778160013
1371 1371 a, c dbSNP:770586875
1374 1374 a, g dbSNP:778689503
1375 1375 a, g dbSNP:745734491
1390 1390 c, t dbSNP:747422624
1391 1391 a, g dbSNP:184167749
1397 1397 c, t dbSNP:374619213
1399 1399 a, g dbSNP:775461315
1407 1407 c, t dbSNP:188372244
1408 1408 a, g dbSNP:192269539
1439 1439 a, g dbSNP:368101881
1454 1454 a, g dbSNP:769976595
1483 1483 g, t dbSNP:73190342
1511 1511 a, g dbSNP:749566350
1535 1535 a, c dbSNP:769017771
1548 1548 a, g dbSNP:112901407
1556 1556 c, t dbSNP:774671452
1593 1593 c, t dbSNP:184377871
1596 1596 c, t dbSNP:188375104
1597 1597 a, g dbSNP:113339335
1600 1600 c, t dbSNP:760524285
1601 1601 a, g dbSNP:28670541
1623 1623 -, t dbSNP:753323054
1624 1624 -, tt dbSNP:764901690
1624 1624 -, t dbSNP:532613188
1679 1679 a, t dbSNP:752250397
1685 1685 a, g dbSNP:373398506
1703 1703 a, g dbSNP:757661250
1704 1704 a, c dbSNP:189561631
1727 1727 g, t dbSNP:28645282
1775 1775 a, g dbSNP:756681584
1790 1790 c, t dbSNP:142367088
1884 1884 c, t dbSNP:182086638
1923 1923 c, g dbSNP:112555123
1926 1926 c, t dbSNP:73607295
1929 1929 -, a dbSNP:768819667
1935 1935 a, c dbSNP:377049799

Target ORF information:

RefSeq Version NM_006883
Organism Homo sapiens (human)
Definition Homo sapiens short stature homeobox (SHOX), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006883

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAAGAGC TCACGGCTTT TGTATCCAAG TCTTTTGACC AGAAAAGCAA GGACGGTAAC 
GGCGGAGGCG GAGGCGGCGG AGGTAAGAAG GATTCCATTA CGTACCGGGA AGTTTTGGAG
AGCGGACTGG CGCGCTCCCG GGAGCTGGGG ACGTCGGATT CCAGCCTCCA GGACATCACG
GAGGGCGGCG GCCACTGCCC GGTGCATTTG TTCAAGGACC ACGTAGACAA TGACAAGGAG
AAACTGAAAG AATTCGGCAC CGCGAGAGTG GCAGAAGGGA TTTATGAATG CAAAGAGAAG
CGCGAGGACG TGAAGTCGGA GGACGAGGAC GGGCAGACCA AGCTGAAACA GAGGCGCAGC
CGCACCAACT TCACGCTGGA GCAGCTGAAC GAGCTCGAGC GACTCTTCGA CGAGACCCAT
TACCCCGACG CCTTCATGCG CGAGGAGCTC AGCCAGCGCC TGGGGCTCTC CGAGGCGCGC
GTGCAGGTTT GGTTCCAGAA CCGGAGAGCC AAGTGCCGCA AACAAGAGAA TCAGATGCAT
AAAGGCGTCA TCTTGGGCAC AGCCAACCAC CTAGACGCCT GCCGAGTGGC ACCCTACGTC
AACATGGGAG CCTTACGGAT GCCTTTCCAA CAGATGGAGT TTTGCTCTTG TCGCCCGGGC
TGGAGTATAA TGGCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.