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SIX1 SIX homeobox 1 [Homo sapiens (human)]

Gene Symbol SIX1
Entrez Gene ID 6495
Full Name SIX homeobox 1
Synonyms BOS3, DFNA23, TIP39
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q23.1

Summary The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601205

Disorder Html: Brachiootic syndrome 3, 608389 (3); Deafness, autosomal dominant 23,





The following SIX1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIX1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26939 NM_005982 Homo sapiens SIX homeobox 1 (SIX1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu26939
Accession Version NM_005982.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein SIX1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC008874.2, X91868.1 and AL049874.3. This sequence is a reference standard in the RefSeqGene project. On Apr 29, 2008 this sequence version replaced gi:142345106. Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008874.2, X91868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGTCGATGC TGCCGTCGTT TGGCTTTACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GCGGAAACCT GGAGCGCCTG GGCAGGTTCC TGTGGTCACT GCCCGCCTGC
GACCACCTGC ACAAGAACGA GAGCGTACTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC
GGCAACTTCC GTGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAC
CCCAAACTGC AGCAACTGTG GCTGAAGGCG CATTACGTGG AGGCCGAGAA GCTGCGCGGC
CGACCCCTGG GCGCCGTGGG CAAATATCGG GTGCGCCGAA AATTTCCACT GCCGCGCACC
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAGA AGTCGAGGGG TGTCCTGCGG
GAGTGGTACG CGCACAATCC CTACCCATCG CCGCGTGAGA AGCGGGAGCT GGCCGAGGCC
ACCGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG
GCCGCGGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG
AACCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTTCTGC TGCAGGGCAA TATGGGCCAC
GCCAGGAGCT CAAACTATTC TCTCCCGGGC TTAACAGCCT CGCAGCCCAG TCACGGCCTG
CAGACCCACC AGCATCAGCT CCAAGACTCT CTGCTCGGCC CCCTCACCTC CAGTCTGGTG
GACTTGGGGT CCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_005973.1
CDS249..1103
Misc Feature(1)147..149(+)
Misc Feature(2)633..788(+)
Misc Feature(3)633..788(+)
Misc Feature(4)636..779(+)
Exon (1)1..808
Gene:SIX1
Gene Synonym:
Exon (2)809..2687
Gene:SIX1
Gene Synonym:
Translation
Position Chain Variation Link
30 30 a, g dbSNP:570347501
36 36 c, g dbSNP:771815597
61 61 c, t dbSNP:550016251
64 64 g, t dbSNP:745791461
65 65 a, c dbSNP:187402923
111 111 a, g, t dbSNP:530225389
112 112 c, t dbSNP:139621918
128 128 -, c dbSNP:564171668
128 128 c, g dbSNP:375002099
170 170 c, t dbSNP:529427457
201 201 a, g dbSNP:560779340
210 210 a, c dbSNP:772231645
212 212 a, c, t dbSNP:779091171
213 213 a, g dbSNP:757701604
219 219 c, g, t dbSNP:777941410
223 223 g, t dbSNP:756474637
224 224 c, t dbSNP:751171137
225 225 c, t dbSNP:201700039
228 228 a, g dbSNP:533496677
231 231 a, c dbSNP:749901536
232 232 c, t dbSNP:764866193
234 234 c, t dbSNP:761639693
235 235 c, g, t dbSNP:374228886
236 236 c, g dbSNP:564123011
246 246 a, g dbSNP:775477360
260 260 a, g dbSNP:772394070
261 261 c, g dbSNP:759906473
262 262 a, c, t dbSNP:771057416
264 264 g, t dbSNP:749690789
271 271 c, g dbSNP:778375446
272 272 c, t dbSNP:770093951
298 298 a, t dbSNP:397515562
309 309 c, t dbSNP:748487541
316 316 a, c dbSNP:781574148
318 318 a, g dbSNP:754869969
323 323 a, c dbSNP:758038091
327 327 c, t dbSNP:544164466
332 332 c, g dbSNP:146357380
341 341 c, t dbSNP:756826384
347 347 c, g, t dbSNP:764103068
360 360 c, g dbSNP:760736490
362 362 c, t dbSNP:752537825
366 366 g, t dbSNP:767478646
380 380 c, g dbSNP:149166341
391 391 a, g dbSNP:774637636
392 392 a, c dbSNP:770875229
398 398 c, g dbSNP:763114674
410 410 a, g dbSNP:150550985
411 411 a, g dbSNP:770253091
414 414 c, g dbSNP:748718182
428 428 c, g dbSNP:781519092
437 437 c, t dbSNP:769018187
454 454 g, t dbSNP:751225628
456 456 c, t dbSNP:372978267
464 464 a, c dbSNP:778653697
475 475 c, t dbSNP:756912951
476 476 a, g dbSNP:753360604
479 479 a, c, t dbSNP:756109319
483 483 a, g dbSNP:752695594
484 484 a, g dbSNP:767354178
489 489 c, t dbSNP:759405851
491 491 c, t dbSNP:369025163
493 493 a, g dbSNP:766600023
504 504 c, t dbSNP:763122547
530 530 a, g dbSNP:773333781
532 532 c, t dbSNP:200835641
539 539 a, g dbSNP:762246254
543 543 c, t dbSNP:17850414
545 545 c, t dbSNP:777157929
554 554 c, t dbSNP:749329131
565 565 g, t dbSNP:397515560
569 569 c, t dbSNP:747379649
576 576 c, t dbSNP:80356459
578 578 a, g dbSNP:73309461
582 582 c, t dbSNP:397515561
587 587 a, c, t dbSNP:770614201
594 594 c, g dbSNP:748953823
595 595 c, t dbSNP:777361656
605 605 c, t dbSNP:375984653
607 607 c, g dbSNP:748057221
612 612 a, t dbSNP:121909770
617 617 c, t dbSNP:781300988
631 631 a, g dbSNP:754918861
634 634 a, g dbSNP:104894478
635 635 c, g dbSNP:371614639
645 645 -, gag dbSNP:80356460
650 650 a, g dbSNP:151189392
653 653 c, g dbSNP:766151467
660 660 c, g dbSNP:758631109
662 662 c, t dbSNP:572940248
666 666 a, c dbSNP:765231579
669 669 a, g dbSNP:761906849
670 670 a, g dbSNP:776744679
681 681 c, g dbSNP:764633083
689 689 c, t dbSNP:761155507
711 711 c, t dbSNP:775911579
712 712 a, g dbSNP:772338719
713 713 a, g dbSNP:748903952
714 714 a, g dbSNP:773031458
716 716 a, g dbSNP:769379475
719 719 c, g dbSNP:368157931
721 721 c, t dbSNP:747639845
722 722 c, g, t dbSNP:199743522
729 729 a, g dbSNP:746973450
730 730 c, g dbSNP:779837812
731 731 c, t dbSNP:758128766
740 740 -, c dbSNP:34585587
742 742 c, t dbSNP:143516729
750 750 a, g dbSNP:371998997
753 753 a, g dbSNP:765427858
771 771 a, c dbSNP:139966458
776 776 a, g dbSNP:553177839
791 791 a, c, t dbSNP:764138955
794 794 a, g dbSNP:761187922
797 797 a, g dbSNP:145953540
809 809 a, g dbSNP:768168468
811 811 a, g dbSNP:760121808
814 814 a, g dbSNP:775109837
819 819 a, g dbSNP:771994916
825 825 a, g dbSNP:574181095
826 826 a, g, t dbSNP:142301715
835 835 c, t dbSNP:749472807
837 837 -, tcc dbSNP:751941823
848 848 a, g dbSNP:61515165
851 851 c, g, t dbSNP:756406449
859 859 c, g dbSNP:752687781
862 862 c, t dbSNP:781397777
863 863 g, t dbSNP:148433316
864 864 c, t dbSNP:543609416
872 872 a, g dbSNP:574706145
874 874 c, g dbSNP:758861510
875 875 a, c dbSNP:753477367
880 880 c, t dbSNP:374638294
884 884 c, t dbSNP:558096446
891 891 a, g dbSNP:560990241
892 892 a, g dbSNP:540778343
897 897 a, g dbSNP:146129487
902 902 a, g dbSNP:774852619
912 912 c, t dbSNP:767030543
927 927 g, t dbSNP:144481204
929 929 a, c, t dbSNP:149265761
930 930 c, g dbSNP:770666125
932 932 c, g dbSNP:749015316
938 938 c, g dbSNP:571997198
939 939 g, t dbSNP:769901336
941 941 a, c dbSNP:748460225
944 944 -, tctgct dbSNP:765979685
945 945 a, c dbSNP:781362403
950 950 a, g dbSNP:755110157
953 953 g, t dbSNP:747474509
954 954 c, g dbSNP:780726681
968 968 c, g, t dbSNP:759290962
969 969 a, g dbSNP:750752374
971 971 c, t dbSNP:765693282
972 972 a, g dbSNP:755668042
973 973 a, g dbSNP:752399991
974 974 a, g dbSNP:766975120
980 980 a, c dbSNP:202018835
982 982 a, g dbSNP:773902181
988 988 a, c dbSNP:766271672
993 993 c, t dbSNP:763012848
994 994 a, c, t dbSNP:368974927
995 995 c, g, t dbSNP:777020182
1002 1002 a, g, t dbSNP:200205240
1009 1009 c, t dbSNP:747061363
1010 1010 g, t dbSNP:780350878
1014 1014 c, t dbSNP:758821559
1023 1023 c, g, t dbSNP:779084301
1027 1027 a, g, t dbSNP:370259896
1030 1030 a, g dbSNP:780802037
1031 1031 a, g dbSNP:754666770
1038 1038 c, g dbSNP:751062848
1047 1047 c, t dbSNP:765929697
1059 1059 -, ct dbSNP:762353418
1059 1059 c, t dbSNP:199522850
1064 1064 c, t dbSNP:750377629
1065 1065 a, g dbSNP:764896733
1070 1070 c, t dbSNP:368353344
1083 1083 c, t dbSNP:12101095
1085 1085 a, g dbSNP:776615090
1091 1091 a, c dbSNP:577150755
1097 1097 a, g dbSNP:761039415
1098 1098 c, t dbSNP:775655341
1100 1100 a, c dbSNP:772202186
1106 1106 a, g dbSNP:746321314
1107 1107 a, c, g dbSNP:771392443
1125 1125 a, g dbSNP:374399275
1127 1127 a, t dbSNP:778176231
1134 1134 c, t dbSNP:754609676
1136 1136 c, t dbSNP:751226156
1152 1152 a, g dbSNP:779363054
1153 1153 c, t dbSNP:757953542
1157 1157 a, g dbSNP:769635996
1165 1165 a, g dbSNP:373673863
1247 1247 a, g dbSNP:113680815
1268 1268 a, g dbSNP:751366842
1271 1271 a, c dbSNP:766323925
1276 1276 c, t dbSNP:568572700
1282 1282 c, g dbSNP:548655754
1292 1292 c, t dbSNP:576067443
1309 1309 a, g, t dbSNP:367844913
1349 1349 a, g dbSNP:61991660
1352 1352 a, g dbSNP:35069179
1352 1352 -, a dbSNP:60585662
1367 1367 -, aa dbSNP:766038211
1367 1367 -, a dbSNP:569977298
1368 1368 -, a dbSNP:112733948
1368 1368 a, c dbSNP:80194537
1381 1381 a, g dbSNP:185694350
1400 1400 g, t dbSNP:147081368
1437 1437 c, g dbSNP:10144415
1468 1468 a, t dbSNP:182923762
1474 1474 a, g dbSNP:538935374
1506 1506 c, t dbSNP:191393983
1507 1507 a, g dbSNP:76116881
1546 1546 a, g dbSNP:186530769
1572 1572 a, g dbSNP:527420447
1583 1583 c, t dbSNP:564879010
1592 1592 a, g dbSNP:57517528
1616 1616 a, t dbSNP:544567737
1681 1681 -, ttta dbSNP:556041829
1705 1705 c, g dbSNP:78909843
1713 1713 g, t dbSNP:557193382
1758 1758 a, c dbSNP:776796977
1762 1762 c, t dbSNP:180814298
1813 1813 -, t dbSNP:751939659
1835 1835 -, t dbSNP:781319339
1839 1839 g, t dbSNP:768828257
1858 1858 -, t dbSNP:398025306
1869 1869 a, t dbSNP:63554860
1869 1869 -, t dbSNP:33943216
1870 1870 -, t dbSNP:199935032
1870 1870 a, t dbSNP:574976629
1872 1872 -, a dbSNP:201192478
1930 1930 a, c dbSNP:554892433
1942 1942 c, g dbSNP:189312189
1985 1985 c, t dbSNP:370867168
1993 1993 -, ctagttt dbSNP:561797428
2111 2111 -, a dbSNP:148821608
2147 2147 g, t dbSNP:3742637
2182 2182 a, t dbSNP:559116477
2195 2195 a, c dbSNP:186149844
2223 2223 a, g dbSNP:3742638
2236 2236 a, c dbSNP:747274676
2299 2299 c, g dbSNP:780378618
2318 2318 c, t dbSNP:181833190
2335 2335 c, t dbSNP:558532789
2354 2354 a, g dbSNP:746385772
2373 2373 -, at dbSNP:3832952
2386 2386 c, t dbSNP:779226095
2387 2387 c, g dbSNP:757802086
2441 2441 c, g dbSNP:550089904
2442 2442 c, t dbSNP:536496013
2479 2479 c, t dbSNP:137994957
2581 2581 c, g dbSNP:146967331
2599 2599 c, t dbSNP:61993831
2619 2619 g, t dbSNP:569954956
2621 2621 c, t dbSNP:547309317
2626 2626 c, t dbSNP:140088005
2681 2681 a, g dbSNP:564608572

Target ORF information:

RefSeq Version NM_005982
Organism Homo sapiens (human)
Definition Homo sapiens SIX homeobox 1 (SIX1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005982

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGTCGATGC TGCCGTCGTT TGGCTTTACG CAGGAGCAAG TGGCGTGCGT GTGCGAGGTT 
CTGCAGCAAG GCGGAAACCT GGAGCGCCTG GGCAGGTTCC TGTGGTCACT GCCCGCCTGC
GACCACCTGC ACAAGAACGA GAGCGTACTC AAGGCCAAGG CGGTGGTCGC CTTCCACCGC
GGCAACTTCC GTGAGCTCTA CAAGATCCTG GAGAGCCACC AGTTCTCGCC TCACAACCAC
CCCAAACTGC AGCAACTGTG GCTGAAGGCG CATTACGTGG AGGCCGAGAA GCTGCGCGGC
CGACCCCTGG GCGCCGTGGG CAAATATCGG GTGCGCCGAA AATTTCCACT GCCGCGCACC
ATCTGGGACG GCGAGGAGAC CAGCTACTGC TTCAAGGAGA AGTCGAGGGG TGTCCTGCGG
GAGTGGTACG CGCACAATCC CTACCCATCG CCGCGTGAGA AGCGGGAGCT GGCCGAGGCC
ACCGGCCTCA CCACCACCCA GGTCAGCAAC TGGTTTAAGA ACCGGAGGCA AAGAGACCGG
GCCGCGGAGG CCAAGGAAAG GGAGAACACC GAAAACAATA ACTCCTCCTC CAACAAGCAG
AACCAACTCT CTCCTCTGGA AGGGGGCAAG CCGCTCATGT CCAGCTCAGA AGAGGAATTC
TCACCTCCCC AAAGTCCAGA CCAGAACTCG GTCCTTCTGC TGCAGGGCAA TATGGGCCAC
GCCAGGAGCT CAAACTATTC TCTCCCGGGC TTAACAGCCT CGCAGCCCAG TCACGGCCTG
CAGACCCACC AGCATCAGCT CCAAGACTCT CTGCTCGGCC CCCTCACCTC CAGTCTGGTG
GACTTGGGGT CCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.