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SLC2A4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SLC2A4
Entrez Gene ID 6517
Full Name solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms GLUT4
General protein information
Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
solute carrier family 2, facilitated glucose transporter member 4
GLUT-4
insulin-responsive glucose transporter type 4
glucose transporter type 4, insulin-responsive
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

138190

Disorder Html: {Diabetes mellitus, noninsulin-dependent}, 125853 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001042 NP_001033 solute carrier family 2, facilitated glucose transporter member 4



Homo sapiens (human) SLC2A4 NP_001033.1
Pan troglodytes (chimpanzee) SLC2A4 XP_001169794.1
Macaca mulatta (Rhesus monkey) SLC2A4 XP_001107391.1
Canis lupus familiaris (dog) SLC2A4 NP_001152799.1
Bos taurus (cattle) SLC2A4 NP_777029.1
Mus musculus (house mouse) Slc2a4 NP_033230.2
Rattus norvegicus (Norway rat) Slc2a4 NP_036883.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLC2A4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC2A4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19065
NM_001042 Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$214.50-$300.30
$429.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19065
Clone ID Related Accession (Same CDS sequence) NM_001042
Accession Version NM_001042.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1530bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product solute carrier family 2, facilitated glucose transporter member 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF594356.1, M20747.1, BC034387.1, AL521328.3, AC003688.1 and BQ775137.1. This sequence is a reference standard in the RefSeqGene project. On Dec 19, 2005 this sequence version replaced gi:4507010. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M20747.1, AK313372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGTCGG GCTTCCAACA GATAGGCTCC GAAGATGGGG AACCCCCTCA GCAGCGAGTG 
ACTGGGACCC TGGTCCTTGC TGTGTTCTCT GCGGTGCTTG GCTCCCTGCA GTTTGGGTAC
AACATTGGGG TCATCAATGC CCCTCAGAAG GTGATTGAAC AGAGCTACAA TGAGACGTGG
CTGGGGAGGC AGGGGCCTGA GGGACCCAGC TCCATCCCTC CAGGCACCCT CACCACCCTC
TGGGCCCTCT CCGTGGCCAT CTTTTCCGTG GGCGGCATGA TTTCCTCCTT CCTCATTGGT
ATCATCTCTC AGTGGCTTGG AAGGAAAAGG GCCATGCTGG TCAACAATGT CCTGGCGGTG
CTGGGGGGCA GCCTCATGGG CCTGGCCAAT GCTGCTGCCT CCTATGAAAT GCTCATCCTT
GGACGATTCC TCATTGGCGC CTACTCAGGG CTGACATCAG GGCTGGTGCC CATGTACGTG
GGGGAGATTG CTCCCACTCA CCTGCGGGGC GCCCTGGGGA CGCTCAACCA ACTGGCCATT
GTTATCGGCA TTCTGATCGC CCAGGTGCTG GGCTTGGAGT CCCTCCTGGG CACTGCCAGC
CTGTGGCCAC TGCTCCTGGG CCTCACAGTG CTACCTGCCC TCCTGCAGCT GGTCCTGCTG
CCCTTCTGTC CCGAGAGCCC CCGCTACCTC TACATCATCC AGAATCTCGA GGGGCCTGCC
AGAAAGAGTC TGAAGCGCCT GACAGGCTGG GCCGATGTTT CTGGAGTGCT GGCTGAGCTG
AAGGATGAGA AGCGGAAGCT GGAGCGTGAG CGGCCACTGT CCCTGCTCCA GCTCCTGGGC
AGCCGTACCC ACCGGCAGCC CCTGATCATT GCGGTCGTGC TGCAGCTGAG CCAGCAGCTC
TCTGGCATCA ATGCTGTTTT CTATTATTCG ACCAGCATCT TCGAGACAGC AGGGGTAGGC
CAGCCTGCCT ATGCCACCAT AGGAGCTGGT GTGGTCAACA CAGTCTTCAC CTTGGTCTCG
GTGTTGTTGG TGGAGCGGGC GGGGCGCCGG ACGCTCCATC TCCTGGGCCT GGCGGGCATG
TGTGGCTGTG CCATCCTGAT GACTGTGGCT CTGCTCCTGC TGGAGCGAGT TCCAGCCATG
AGCTACGTCT CCATTGTGGC CATCTTTGGC TTCGTGGCAT TTTTTGAGAT TGGCCCTGGC
CCCATTCCTT GGTTCATCGT GGCCGAGCTC TTCAGCCAGG GACCCCGCCC GGCAGCCATG
GCTGTGGCTG GTTTCTCCAA CTGGACGAGC AACTTCATCA TTGGCATGGG TTTCCAGTAT
GTTGCGGAGG CTATGGGGCC CTACGTCTTC CTTCTATTTG CGGTCCTCCT GCTGGGCTTC
TTCATCTTCA CCTTCTTAAG AGTACCTGAA ACTCGAGGCC GGACGTTTGA CCAGATCTCA
GCTGCCTTCC ACCGGACACC CTCTCTTTTA GAGCAGGAGG TGAAACCCAG CACAGAACTT
GAGTATTTAG GGCCAGATGA GAACGACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001033.1
CDS201..1730
Misc Feature(1)192..194(+)
Misc Feature(2)219..239(+)
Misc Feature(3)273..335(+)
Misc Feature(4)282..1649(+)
Misc Feature(5)432..1541(+)
Misc Feature(6)444..506(+)
Misc Feature(7)453..1493(+)
Misc Feature(8)534..596(+)
Misc Feature(9)627..689(+)
Misc Feature(10)714..776(+)
Misc Feature(11)804..866(+)
Misc Feature(12)1020..1022(+)
Misc Feature(13)1062..1124(+)
Misc Feature(14)1083..1091(+)
Misc Feature(15)1170..1232(+)
Misc Feature(16)1260..1322(+)
Misc Feature(17)1353..1415(+)
Misc Feature(18)1452..1514(+)
Misc Feature(19)1536..1598(+)
Misc Feature(20)1665..1670(+)
Exon (1)1..233
Gene:SLC2A4
Gene Synonym:
Exon (2)234..350
Gene:SLC2A4
Gene Synonym:
Exon (3)351..523
Gene:SLC2A4
Gene Synonym:
Exon (4)524..648
Gene:SLC2A4
Gene Synonym:
Exon (5)649..764
Gene:SLC2A4
Gene Synonym:
Exon (6)765..927
Gene:SLC2A4
Gene Synonym:
Exon (7)928..1115
Gene:SLC2A4
Gene Synonym:
Exon (8)1116..1220
Gene:SLC2A4
Gene Synonym:
Exon (9)1221..1322
Gene:SLC2A4
Gene Synonym:
Exon (10)1323..1526
Gene:SLC2A4
Gene Synonym:
Exon (11)1527..3149
Gene:SLC2A4
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001042
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001042

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGTCGG GCTTCCAACA GATAGGCTCC GAAGATGGGG AACCCCCTCA GCAGCGAGTG 
ACTGGGACCC TGGTCCTTGC TGTGTTCTCT GCGGTGCTTG GCTCCCTGCA GTTTGGGTAC
AACATTGGGG TCATCAATGC CCCTCAGAAG GTGATTGAAC AGAGCTACAA TGAGACGTGG
CTGGGGAGGC AGGGGCCTGA GGGACCCAGC TCCATCCCTC CAGGCACCCT CACCACCCTC
TGGGCCCTCT CCGTGGCCAT CTTTTCCGTG GGCGGCATGA TTTCCTCCTT CCTCATTGGT
ATCATCTCTC AGTGGCTTGG AAGGAAAAGG GCCATGCTGG TCAACAATGT CCTGGCGGTG
CTGGGGGGCA GCCTCATGGG CCTGGCCAAT GCTGCTGCCT CCTATGAAAT GCTCATCCTT
GGACGATTCC TCATTGGCGC CTACTCAGGG CTGACATCAG GGCTGGTGCC CATGTACGTG
GGGGAGATTG CTCCCACTCA CCTGCGGGGC GCCCTGGGGA CGCTCAACCA ACTGGCCATT
GTTATCGGCA TTCTGATCGC CCAGGTGCTG GGCTTGGAGT CCCTCCTGGG CACTGCCAGC
CTGTGGCCAC TGCTCCTGGG CCTCACAGTG CTACCTGCCC TCCTGCAGCT GGTCCTGCTG
CCCTTCTGTC CCGAGAGCCC CCGCTACCTC TACATCATCC AGAATCTCGA GGGGCCTGCC
AGAAAGAGTC TGAAGCGCCT GACAGGCTGG GCCGATGTTT CTGGAGTGCT GGCTGAGCTG
AAGGATGAGA AGCGGAAGCT GGAGCGTGAG CGGCCACTGT CCCTGCTCCA GCTCCTGGGC
AGCCGTACCC ACCGGCAGCC CCTGATCATT GCGGTCGTGC TGCAGCTGAG CCAGCAGCTC
TCTGGCATCA ATGCTGTTTT CTATTATTCG ACCAGCATCT TCGAGACAGC AGGGGTAGGC
CAGCCTGCCT ATGCCACCAT AGGAGCTGGT GTGGTCAACA CAGTCTTCAC CTTGGTCTCG
GTGTTGTTGG TGGAGCGGGC GGGGCGCCGG ACGCTCCATC TCCTGGGCCT GGCGGGCATG
TGTGGCTGTG CCATCCTGAT GACTGTGGCT CTGCTCCTGC TGGAGCGAGT TCCAGCCATG
AGCTACGTCT CCATTGTGGC CATCTTTGGC TTCGTGGCAT TTTTTGAGAT TGGCCCTGGC
CCCATTCCTT GGTTCATCGT GGCCGAGCTC TTCAGCCAGG GACCCCGCCC GGCAGCCATG
GCTGTGGCTG GTTTCTCCAA CTGGACGAGC AACTTCATCA TTGGCATGGG TTTCCAGTAT
GTTGCGGAGG CTATGGGGCC CTACGTCTTC CTTCTATTTG CGGTCCTCCT GCTGGGCTTC
TTCATCTTCA CCTTCTTAAG AGTACCTGAA ACTCGAGGCC GGACGTTTGA CCAGATCTCA
GCTGCCTTCC ACCGGACACC CTCTCTTTTA GAGCAGGAGG TGAAACCCAG CACAGAACTT
GAGTATTTAG GGCCAGATGA GAACGACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Functional roles of BCAR3 in the signaling pathways of insulin leading to DNA synthesis, membrane ruffling and GLUT4 translocation
Biochem. Biophys. Res. Commun. 441 (4), 911-916 (2013)
Oh MJ, Yi SJ, Kim HS, Kim JH, Jeong YH, van Agthoven T and Jhun BH.


book

Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: a randomized study using FDG PET imaging
Am. J. Physiol. Endocrinol. Metab. 305 (4), E496-E506 (2013)
Reichkendler MH, Auerbach P, Rosenkilde M, Christensen AN, Holm S, Petersen MB, Lagerberg A, Larsson HB, Rostrup E, Mosbech TH, Sjodin A, Kjaer A, Ploug T, Hoejgaard L and Stallknecht B.


book

SLC2A4gene: a promising target for pharmacogenomics of insulin resistance
Pharmacogenomics 14 (8), 847-850 (2013)
Correa-Giannella,M.L. and Machado,U.F.


book

17beta-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells
Endocrinology 154 (6), 1979-1989 (2013)
Garrido P, Moran J, Alonso A, Gonzalez S and Gonzalez C.


book

Critical illness myopathy and GLUT4: significance of insulin and muscle contraction
Am. J. Respir. Crit. Care Med. 187 (4), 387-396 (2013)
Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J and Spuler S.


book

Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation
Diabetes 41 (11), 1436-1445 (1992)
Buse JB, Yasuda K, Lay TP, Seo TS, Olson AL, Pessin JE, Karam JH, Seino S and Bell GI.


book

Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice
J. Biol. Chem. 267 (17), 11673-11676 (1992)
Liu ML, Olson AL, Moye-Rowley WS, Buse JB, Bell GI and Pessin JE.


book

Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population
Diabetologia 35 (5), 486-489 (1992)
O'Rahilly S, Krook A, Morgan R, Rees A, Flier JS and Moller DE.


book

Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects
Diabetes 40 (12), 1712-1718 (1991)
Choi WH, O'Rahilly S, Buse JB, Rees A, Morgan R, Flier JS and Moller DE.


book

Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus
J. Clin. Invest. 88 (4), 1323-1330 (1991)
Kusari J, Verma US, Buse JB, Henry RR and Olefsky JM.


 
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