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SLC6A8 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SLC6A8
Entrez Gene ID 6535
Full Name solute carrier family 6 (neurotransmitter transporter), member 8
Synonyms CCDS1, CRT, CRTR, CT1, CTR5
General protein information
Preferred Names
sodium- and chloride-dependent creatine transporter 1
Names
sodium- and chloride-dependent creatine transporter 1
creatine transporter 1
creatine transporter SLC6A8
solute carrier family 6 member 8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. lac of sum
Disorder MIM:

300036

Disorder Html: Creatine deficiency syndrome, X-linked, 300352 (3)





The following SLC6A8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC6A8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27787 NM_001142805 Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD Quote Price
OHu27780 NM_001142806 Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.30
$379.00
OHu27778 NM_005629 Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$307.30
$439.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27787
Accession Version NM_001142805.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1878bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product sodium- and chloride-dependent creatine transporter 1 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC081558.1, L31409.1, AB209704.1, U52111.3, CX788315.1, BE207407.1 and CA424985.1. Summary: The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks a 10-aa segment but has the same N- and C-termini, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB209704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001136277.1
CDS279..2156
Misc Feature(1)219..221(+)
Misc Feature(2)402..404(+)
Misc Feature(3)432..2111(+)
Misc Feature(4)459..521(+)
Misc Feature(5)477..1499(+)
Misc Feature(6)540..602(+)
Misc Feature(7)693..755(+)
Misc Feature(8)969..1031(+)
Misc Feature(9)1086..1148(+)
Misc Feature(10)1191..1253(+)
Misc Feature(11)1431..1493(+)
Misc Feature(12)1581..1643(+)
Misc Feature(13)1686..1748(+)
Misc Feature(14)1809..1871(+)
Misc Feature(15)1929..1991(+)
Exon (1)1..540
Gene:SLC6A8
Gene Synonym:
Exon (2)541..672
Gene:SLC6A8
Gene Synonym:
Exon (3)673..922
Gene:SLC6A8
Gene Synonym:
Exon (4)923..1055
Gene:SLC6A8
Gene Synonym:
Exon (5)1056..1190
Gene:SLC6A8
Gene Synonym:
Exon (6)1191..1294
Gene:SLC6A8
Gene Synonym:
Exon (7)1295..1389
Gene:SLC6A8
Gene Synonym:
Exon (8)1390..1502
Gene:SLC6A8
Gene Synonym:
Exon (9)1503..1640
Gene:SLC6A8
Gene Synonym:
Exon (10)1641..1743
Gene:SLC6A8
Gene Synonym:
Exon (11)1744..1844
Gene:SLC6A8
Gene Synonym:
Exon (12)1845..2015
Gene:SLC6A8
Gene Synonym:
Exon (13)2016..3535
Gene:SLC6A8
Gene Synonym:
Translation
Position Chain Variation Link
274 274 a, g dbSNP:384573
537 537 a, g dbSNP:122453115
599 599 -, ctt dbSNP:80338739
673 673 g, t dbSNP:122453117
1289 1289 c, g dbSNP:122453116
1389 1389 c, g dbSNP:122453114
1470 1470 -, ttc dbSNP:80338740
1721 1721 c, g, t dbSNP:122453118
1788 1788 c, t dbSNP:122453113
1879 1879 c, t dbSNP:397515558
1909 1909 c, t dbSNP:397515559
2178 2178 a, c dbSNP:58611639
2363 2363 c, g dbSNP:6571290
2461 2461 c, t dbSNP:60100462
2627 2627 a, g dbSNP:4532754
2719 2719 c, t dbSNP:145908010

Target ORF information:

RefSeq Version NM_001142805
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001142805

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAATGGG
ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC TCCATCCTGG GCTTCATGGC TGCAGAGCAG
GGCGTGCACA TCTCCAAGGT GGCAGAGTCA GGGCCGGGCC TGGCCTTCAT CGCCTACCCG
CGGGCTGTCA CGCTGATGCC AGTGGCCCCA CTCTGGGCTG CCCTGTTCTT CTTCATGCTG
TTGCTGCTTG GTCTCGACAG CCAGTTTGTA GGTGTGGAGG GCTTCATCAC CGGCCTCCTC
GACCTCCTCC CGGCCTCCTA CTACTTCCGT TTCCAAAGGG AGATCTCTGT GGCCCTCTGT
TGTGCCCTCT GCTTTGTCAT CGATCTCTCC ATGGTGACTG ATGGCGGGAT GTACGTCTTC
CAGCTGTTTG ACTACTACTC GGCCAGCGGC ACCACCCTGC TCTGGCAGGC CTTTTGGGAG
TGCGTGGTGG TGGCCTGGGT GTACGGAGCT GACCGCTTCA TGGACGACAT TGCCTGTATG
ATCGGGTACC GACCTTGCCC CTGGATGAAA TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC
TGCATGGGCA TCTTCATCTT CAACGTTGTG TACTACGAGC CGCTGGTCTA CAACAACACC
TACGTGTACC CGTGGTGGGG TGAGGCCATG GGCTGGGCCT TCGCCCTGTC CTCCATGCTG
TGCGTGCCGC TGCACCTCCT GGGCTGCCTC CTCAGGGCCA AGGGCACCAT GGCTGAGCGC
TGGCAGCACC TGACCCAGCC CATCTGGGGC CTCCACCACT TGGAGTACCG AGCTCAGGAC
GCAGATGTCA GGGGCCTGAC CACCCTGACC CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG
GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27780
Accession Version NM_001142806.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1563bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product sodium- and chloride-dependent creatine transporter 1 isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295495.1, U52111.3, BC012355.1, CX788315.1, BE207407.1 and CA424985.1. Summary: The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGAAGGCCG GCAGCATCAA TGTCTGGAAC ATCTGTCCCC TGTTCAAAGG CCTGGGCTAC 
GCCTCCATGG TGATCGTCTT CTACTGCAAC ACCTACTACA TCATGGTGCT GGCCTGGGGC
TTCTATTACC TGGTCAAGTC CTTTACCACC ACGCTGCCCT GGGCCACATG TGGCCACACC
TGGAACACTC CCGACTGCGT GGAGATCTTC CGCCATGAAG ACTGTGCCAA TGCCAGCCTG
GCCAACCTCA CCTGTGACCA GCTTGCTGAC CGCCGGTCCC CTGTCATCGA GTTCTGGGAG
AACAAAGTCT TGAGGCTGTC TGGGGGACTG GAGGTGCCAG GGGCCCTCAA CTGGGAGGTG
ACCCTTTGTC TGCTGGCCTG CTGGGTGCTG GTCTACTTCT GTGTCTGGAA GGGGGTCAAA
TCCACGGGAA AGATCGTGTA CTTCACTGCT ACATTCCCCT ACGTGGTCCT GGTCGTGCTG
CTGGTGCGTG GAGTGCTGCT GCCTGGCGCC CTGGATGGCA TCATTTACTA TCTCAAGCCT
GACTGGTCAA AGCTGGGGTC CCCTCAGGTG TGGATAGATG CGGGGACCCA GATTTTCTTT
TCTTACGCCA TTGGCCTGGG GGCCCTCACA GCCCTGGGCA GCTACAACCG CTTCAACAAC
AACTGCTACA AGGACGCCAT CATCCTGGCT CTCATCAACA GTGGGACCAG CTTCTTTGCT
GGCTTCGTGG TCTTCTCCAT CCTGGGCTTC ATGGCTGCAG AGCAGGGCGT GCACATCTCC
AAGGTGGCAG AGTCAGGGCC GGGCCTGGCC TTCATCGCCT ACCCGCGGGC TGTCACGCTG
ATGCCAGTGG CCCCACTCTG GGCTGCCCTG TTCTTCTTCA TGCTGTTGCT GCTTGGTCTC
GACAGCCAGT TTGTAGGTGT GGAGGGCTTC ATCACCGGCC TCCTCGACCT CCTCCCGGCC
TCCTACTACT TCCGTTTCCA AAGGGAGATC TCTGTGGCCC TCTGTTGTGC CCTCTGCTTT
GTCATCGATC TCTCCATGGT GACTGATGGC GGGATGTACG TCTTCCAGCT GTTTGACTAC
TACTCGGCCA GCGGCACCAC CCTGCTCTGG CAGGCCTTTT GGGAGTGCGT GGTGGTGGCC
TGGGTGTACG GAGCTGACCG CTTCATGGAC GACATTGCCT GTATGATCGG GTACCGACCT
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCGC TGGTCTGCAT GGGCATCTTC
ATCTTCAACG TTGTGTACTA CGAGCCGCTG GTCTACAACA ACACCTACGT GTACCCGTGG
TGGGGTGAGG CCATGGGCTG GGCCTTCGCC CTGTCCTCCA TGCTGTGCGT GCCGCTGCAC
CTCCTGGGCT GCCTCCTCAG GGCCAAGGGC ACCATGGCTG AGCGCTGGCA GCACCTGACC
CAGCCCATCT GGGGCCTCCA CCACTTGGAG TACCGAGCTC AGGACGCAGA TGTCAGGGGC
CTGACCACCC TGACCCCAGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001136278.1
CDS173..1735
Misc Feature(1)5..7(+)
Misc Feature(2)173..1690(+)
Misc Feature(3)1064..1078(+)
Exon (1)1..89
Gene:SLC6A8
Gene Synonym:
Exon (2)90..221
Gene:SLC6A8
Gene Synonym:
Exon (3)222..471
Gene:SLC6A8
Gene Synonym:
Exon (4)472..604
Gene:SLC6A8
Gene Synonym:
Exon (5)605..739
Gene:SLC6A8
Gene Synonym:
Exon (6)740..843
Gene:SLC6A8
Gene Synonym:
Exon (7)844..968
Gene:SLC6A8
Gene Synonym:
Exon (8)969..1081
Gene:SLC6A8
Gene Synonym:
Exon (9)1082..1219
Gene:SLC6A8
Gene Synonym:
Exon (10)1220..1322
Gene:SLC6A8
Gene Synonym:
Exon (11)1323..1423
Gene:SLC6A8
Gene Synonym:
Exon (12)1424..1594
Gene:SLC6A8
Gene Synonym:
Exon (13)1595..3114
Gene:SLC6A8
Gene Synonym:
Translation
Position Chain Variation Link
148 148 -, ctt dbSNP:80338739
222 222 g, t dbSNP:122453117
838 838 c, g dbSNP:122453116
968 968 c, g dbSNP:122453114
1049 1049 -, ttc dbSNP:80338740
1300 1300 c, g, t dbSNP:122453118
1367 1367 c, t dbSNP:122453113
1458 1458 c, t dbSNP:397515558
1488 1488 c, t dbSNP:397515559
1757 1757 a, c dbSNP:58611639
1942 1942 c, g dbSNP:6571290
2040 2040 c, t dbSNP:60100462
2206 2206 a, g dbSNP:4532754
2298 2298 c, t dbSNP:145908010

Target ORF information:

RefSeq Version NM_001142806
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001142806

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGAAGGCCG GCAGCATCAA TGTCTGGAAC ATCTGTCCCC TGTTCAAAGG CCTGGGCTAC 
GCCTCCATGG TGATCGTCTT CTACTGCAAC ACCTACTACA TCATGGTGCT GGCCTGGGGC
TTCTATTACC TGGTCAAGTC CTTTACCACC ACGCTGCCCT GGGCCACATG TGGCCACACC
TGGAACACTC CCGACTGCGT GGAGATCTTC CGCCATGAAG ACTGTGCCAA TGCCAGCCTG
GCCAACCTCA CCTGTGACCA GCTTGCTGAC CGCCGGTCCC CTGTCATCGA GTTCTGGGAG
AACAAAGTCT TGAGGCTGTC TGGGGGACTG GAGGTGCCAG GGGCCCTCAA CTGGGAGGTG
ACCCTTTGTC TGCTGGCCTG CTGGGTGCTG GTCTACTTCT GTGTCTGGAA GGGGGTCAAA
TCCACGGGAA AGATCGTGTA CTTCACTGCT ACATTCCCCT ACGTGGTCCT GGTCGTGCTG
CTGGTGCGTG GAGTGCTGCT GCCTGGCGCC CTGGATGGCA TCATTTACTA TCTCAAGCCT
GACTGGTCAA AGCTGGGGTC CCCTCAGGTG TGGATAGATG CGGGGACCCA GATTTTCTTT
TCTTACGCCA TTGGCCTGGG GGCCCTCACA GCCCTGGGCA GCTACAACCG CTTCAACAAC
AACTGCTACA AGGACGCCAT CATCCTGGCT CTCATCAACA GTGGGACCAG CTTCTTTGCT
GGCTTCGTGG TCTTCTCCAT CCTGGGCTTC ATGGCTGCAG AGCAGGGCGT GCACATCTCC
AAGGTGGCAG AGTCAGGGCC GGGCCTGGCC TTCATCGCCT ACCCGCGGGC TGTCACGCTG
ATGCCAGTGG CCCCACTCTG GGCTGCCCTG TTCTTCTTCA TGCTGTTGCT GCTTGGTCTC
GACAGCCAGT TTGTAGGTGT GGAGGGCTTC ATCACCGGCC TCCTCGACCT CCTCCCGGCC
TCCTACTACT TCCGTTTCCA AAGGGAGATC TCTGTGGCCC TCTGTTGTGC CCTCTGCTTT
GTCATCGATC TCTCCATGGT GACTGATGGC GGGATGTACG TCTTCCAGCT GTTTGACTAC
TACTCGGCCA GCGGCACCAC CCTGCTCTGG CAGGCCTTTT GGGAGTGCGT GGTGGTGGCC
TGGGTGTACG GAGCTGACCG CTTCATGGAC GACATTGCCT GTATGATCGG GTACCGACCT
TGCCCCTGGA TGAAATGGTG CTGGTCCTTC TTCACCCCGC TGGTCTGCAT GGGCATCTTC
ATCTTCAACG TTGTGTACTA CGAGCCGCTG GTCTACAACA ACACCTACGT GTACCCGTGG
TGGGGTGAGG CCATGGGCTG GGCCTTCGCC CTGTCCTCCA TGCTGTGCGT GCCGCTGCAC
CTCCTGGGCT GCCTCCTCAG GGCCAAGGGC ACCATGGCTG AGCGCTGGCA GCACCTGACC
CAGCCCATCT GGGGCCTCCA CCACTTGGAG TACCGAGCTC AGGACGCAGA TGTCAGGGGC
CTGACCACCC TGACCCCAGT GTCCGAGAGC AGCAAGGTCG TCGTGGTGGA GAGTGTCATG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27778
Accession Version NM_005629.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1908bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product sodium- and chloride-dependent creatine transporter 1 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC081558.1, L31409.1, U52111.3, CX788315.1, BE207407.1 and CA424985.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2008 this sequence version replaced gi:183979976. Summary: The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081558.1, L31409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_005620.1
CDS279..2186
Misc Feature(1)219..221(+)
Misc Feature(2)402..404(+)
Misc Feature(3)432..2141(+)
Misc Feature(4)459..521(+)
Misc Feature(5)477..1529(+)
Misc Feature(6)480..1541(+)
Misc Feature(7)483..1322(+)
Misc Feature(8)504..1436(+)
Misc Feature(9)540..602(+)
Misc Feature(10)693..755(+)
Misc Feature(11)969..1031(+)
Misc Feature(12)1086..1148(+)
Misc Feature(13)1191..1253(+)
Misc Feature(14)1302..1364(+)
Misc Feature(15)1461..1523(+)
Misc Feature(16)1611..1673(+)
Misc Feature(17)1716..1778(+)
Misc Feature(18)1839..1901(+)
Misc Feature(19)1920..1922(+)
Misc Feature(20)1959..2021(+)
Exon (1)1..540
Gene:SLC6A8
Gene Synonym:
Exon (2)541..672
Gene:SLC6A8
Gene Synonym:
Exon (3)673..922
Gene:SLC6A8
Gene Synonym:
Exon (4)923..1055
Gene:SLC6A8
Gene Synonym:
Exon (5)1056..1190
Gene:SLC6A8
Gene Synonym:
Exon (6)1191..1294
Gene:SLC6A8
Gene Synonym:
Exon (7)1295..1419
Gene:SLC6A8
Gene Synonym:
Exon (8)1420..1532
Gene:SLC6A8
Gene Synonym:
Exon (9)1533..1670
Gene:SLC6A8
Gene Synonym:
Exon (10)1671..1773
Gene:SLC6A8
Gene Synonym:
Exon (11)1774..1874
Gene:SLC6A8
Gene Synonym:
Exon (12)1875..2045
Gene:SLC6A8
Gene Synonym:
Exon (13)2046..3565
Gene:SLC6A8
Gene Synonym:
Translation
Position Chain Variation Link
274 274 a, g dbSNP:384573
537 537 a, g dbSNP:122453115
599 599 -, ctt dbSNP:80338739
673 673 g, t dbSNP:122453117
1289 1289 c, g dbSNP:122453116
1419 1419 c, g dbSNP:122453114
1500 1500 -, ttc dbSNP:80338740
1751 1751 c, g, t dbSNP:122453118
1818 1818 c, t dbSNP:122453113
1909 1909 c, t dbSNP:397515558
1939 1939 c, t dbSNP:397515559
2208 2208 a, c dbSNP:58611639
2393 2393 c, g dbSNP:6571290
2491 2491 c, t dbSNP:60100462
2657 2657 a, g dbSNP:4532754
2749 2749 c, t dbSNP:145908010

Target ORF information:

RefSeq Version NM_005629
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005629

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGCGAAGA AGAGCGCCGA GAACGGCATC TATAGCGTGT CCGGCGACGA GAAGAAGGGC 
CCCCTCATCG CGCCCGGGCC CGACGGGGCC CCGGCCAAGG GCGACGGCCC CGTGGGCCTG
GGGACACCCG GCGGCCGCCT GGCCGTGCCG CCGCGCGAGA CCTGGACGCG CCAGATGGAC
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCTTGGGCA ACGTGTGGCG CTTCCCCTAC
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ACGTCCTGAT CGCCCTGGTT
GGAGGAATCC CCATTTTCTT CTTAGAGATC TCGCTGGGCC AGTTCATGAA GGCCGGCAGC
ATCAATGTCT GGAACATCTG TCCCCTGTTC AAAGGCCTGG GCTACGCCTC CATGGTGATC
GTCTTCTACT GCAACACCTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC
AAGTCCTTTA CCACCACGCT GCCCTGGGCC ACATGTGGCC ACACCTGGAA CACTCCCGAC
TGCGTGGAGA TCTTCCGCCA TGAAGACTGT GCCAATGCCA GCCTGGCCAA CCTCACCTGT
GACCAGCTTG CTGACCGCCG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG
CTGTCTGGGG GACTGGAGGT GCCAGGGGCC CTCAACTGGG AGGTGACCCT TTGTCTGCTG
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTC TGGAAGGGGG TCAAATCCAC GGGAAAGATC
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTGGTCG TGCTGCTGGT GCGTGGAGTG
CTGCTGCCTG GCGCCCTGGA TGGCATCATT TACTATCTCA AGCCTGACTG GTCAAAGCTG
GGGTCCCCTC AGGTGTGGAT AGATGCGGGG ACCCAGATTT TCTTTTCTTA CGCCATTGGC
CTGGGGGCCC TCACAGCCCT GGGCAGCTAC AACCGCTTCA ACAACAACTG CTACAAGGAC
GCCATCATCC TGGCTCTCAT CAACAGTGGG ACCAGCTTCT TTGCTGGCTT CGTGGTCTTC
TCCATCCTGG GCTTCATGGC TGCAGAGCAG GGCGTGCACA TCTCCAAGGT GGCAGAGTCA
GGGCCGGGCC TGGCCTTCAT CGCCTACCCG CGGGCTGTCA CGCTGATGCC AGTGGCCCCA
CTCTGGGCTG CCCTGTTCTT CTTCATGCTG TTGCTGCTTG GTCTCGACAG CCAGTTTGTA
GGTGTGGAGG GCTTCATCAC CGGCCTCCTC GACCTCCTCC CGGCCTCCTA CTACTTCCGT
TTCCAAAGGG AGATCTCTGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC GGCCAGCGGC
ACCACCCTGC TCTGGCAGGC CTTTTGGGAG TGCGTGGTGG TGGCCTGGGT GTACGGAGCT
GACCGCTTCA TGGACGACAT TGCCTGTATG ATCGGGTACC GACCTTGCCC CTGGATGAAA
TGGTGCTGGT CCTTCTTCAC CCCGCTGGTC TGCATGGGCA TCTTCATCTT CAACGTTGTG
TACTACGAGC CGCTGGTCTA CAACAACACC TACGTGTACC CGTGGTGGGG TGAGGCCATG
GGCTGGGCCT TCGCCCTGTC CTCCATGCTG TGCGTGCCGC TGCACCTCCT GGGCTGCCTC
CTCAGGGCCA AGGGCACCAT GGCTGAGCGC TGGCAGCACC TGACCCAGCC CATCTGGGGC
CTCCACCACT TGGAGTACCG AGCTCAGGAC GCAGATGTCA GGGGCCTGAC CACCCTGACC
CCAGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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