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SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Homo sapiens (human)]

Gene Symbol SMARCE1
Entrez Gene ID 6605
Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms BAF57
General protein information
Preferred Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
BRG1-associated factor 57
chromatin remodeling complex BRG1-associated factor 57
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.2

Summary The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

603111

Disorder Html:





The following SMARCE1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMARCE1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24945 NM_003079 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu24945
Accession Version NM_003079.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1236bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu24945D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ707908.1, AK095047.1 and BC063700.1. This sequence is a reference standard in the RefSeqGene project. On Mar 30, 2004 this sequence version replaced gi:21264354. Summary: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069196.1, AK095047.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGTCAAAAA GACCATCTTA TGCCCCACCT CCCACCCCAG CTCCTGCAAC ACAAATGCCC 
AGCACACCAG GGTTTGTGGG ATACAATCCA TACAGTCATC TCGCCTACAA CAACTACAGG
CTGGGAGGGA ACCCGGGCAC CAACAGCCGG GTCACGGCAT CCTCTGGTAT CACGATTCCA
AAACCCCCAA AGCCACCAGA TAAGCCGCTG ATGCCCTACA TGAGGTACAG CAGAAAGGTC
TGGGACCAAG TAAAGGCTTC CAACCCTGAC CTAAAGTTGT GGGAGATTGG CAAGATTATT
GGTGGCATGT GGCGAGATCT CACTGATGAA GAAAAACAAG AATATTTAAA CGAATACGAA
GCAGAAAAGA TAGAGTACAA TGAATCTATG AAGGCCTATC ATAATTCCCC CGCGTACCTT
GCTTACATAA ATGCAAAAAG TCGTGCAGAA GCTGCTTTAG AGGAAGAAAG TCGACAGAGA
CAATCTCGCA TGGAGAAAGG AGAACCGTAC ATGAGCATTC AGCCTGCTGA AGATCCAGAT
GATTATGATG ATGGCTTTTC AATGAAGCAT ACAGCCACCG CCCGTTTCCA GAGAAACCAC
CGCCTCATCA GTGAAATTCT TAGTGAGAGT GTGGTGCCAG ACGTTCGGTC AGTTGTCACA
ACAGCTAGAA TGCAGGTCCT CAAACGGCAG GTCCAGTCCT TAATGGTTCA TCAGCGAAAA
CTAGAAGCTG AACTTCTTCA AATAGAGGAA CGACACCAGG AGAAGAAGAG GAAATTCCTG
GAAAGCACAG ATTCATTTAA CAATGAACTT AAAAGGTTGT GCGGTCTGAA AGTAGAAGTG
GATATGGAGA AAATTGCAGC TGAGATTGCA CAGGCAGAGG AACAGGCCCG CAAAAGGCAG
GAGGAAAGGG AGAAGGAGGC CGCAGAGCAA GCTGAGCGCA GTCAGAGCAG CATCGTTCCT
GAGGAAGAAC AAGCAGCTAA CAAAGGCGAG GAGAAGAAAG ACGACGAGAA CATTCCGATG
GAGACAGAGG AGACACACCT TGAAGAAACA ACAGAGAGCC AACAGAATGG TGAAGAAGGC
ACGTCTACTC CTGAGGACAA GGAGAGTGGG CAGGAGGGGG TCGACAGTAT GGCAGAGGAA
GGAACCAGTG ATAGTAACAC TGGCTCGGAG AGCAACAGTG CAACAGTGGA GGAGCCACCA
ACAGATCCCA TACCAGAAGA TGAGAAAAAA GAATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003070.3
CDS125..1360
Misc Feature(1)113..115(+)
Misc Feature(2)332..517(+)
Misc Feature(3)332..493(+)
Misc Feature(4)773..1024(+)
Misc Feature(5)917..919(+)
Exon (1)1..79
Gene:SMARCE1
Gene Synonym:
Exon (2)80..131
Gene:SMARCE1
Gene Synonym:
Exon (3)132..175
Gene:SMARCE1
Gene Synonym:
Exon (4)176..280
Gene:SMARCE1
Gene Synonym:
Exon (5)281..361
Gene:SMARCE1
Gene Synonym:
Exon (6)362..493
Gene:SMARCE1
Gene Synonym:
Exon (7)494..665
Gene:SMARCE1
Gene Synonym:
Exon (8)666..838
Gene:SMARCE1
Gene Synonym:
Exon (9)839..940
Gene:SMARCE1
Gene Synonym:
Exon (10)941..1151
Gene:SMARCE1
Gene Synonym:
Exon (11)1152..2425
Gene:SMARCE1
Gene Synonym:
Translation
Position Chain Variation Link
6 6 a, g dbSNP:751778345
12 12 c, g dbSNP:572001403
31 31 a, g dbSNP:553362526
45 45 a, g dbSNP:141077617
52 52 a, g dbSNP:577564995
55 55 ctgc, gg dbSNP:386796993
86 86 a, g dbSNP:776953565
181 181 g, t dbSNP:142279746
184 184 a, c dbSNP:754255521
193 193 a, g dbSNP:766668916
210 210 a, g dbSNP:760888905
214 214 a, t dbSNP:750602675
231 231 a, g dbSNP:767656838
255 255 a, c dbSNP:761846539
256 256 c, t dbSNP:570462841
259 259 a, g dbSNP:148373393
260 260 a, g dbSNP:11548762
292 292 c, t dbSNP:773059312
298 298 a, g dbSNP:201976136
307 307 a, c dbSNP:12103928
316 316 a, g dbSNP:747774987
331 331 a, g, t dbSNP:373563447
341 341 c, t dbSNP:62066644
342 342 a, g dbSNP:387906857
385 385 c, t dbSNP:767272636
388 388 c, t dbSNP:761400708
397 397 a, g dbSNP:774003279
424 424 a, t dbSNP:143363725
435 435 a, g dbSNP:397509407
454 454 a, c dbSNP:372964610
475 475 c, t dbSNP:149613910
481 481 c, t dbSNP:770298495
493 493 a, g dbSNP:746320191
497 497 c, g dbSNP:762580699
505 505 c, t dbSNP:574039127
510 510 a, c dbSNP:769255223
511 511 c, t dbSNP:746386326
530 530 g, t dbSNP:538476076
535 535 c, t dbSNP:777241499
536 536 a, g dbSNP:771308672
537 537 c, t dbSNP:747470831
538 538 a, g, t dbSNP:555651762
551 551 a, g dbSNP:772432672
561 561 a, g dbSNP:748318573
564 564 a, g dbSNP:779169160
566 566 c, t dbSNP:147065057
567 567 a, g dbSNP:755039445
577 577 c, t dbSNP:534177014
579 579 c, t dbSNP:781231331
597 597 a, g dbSNP:757138170
611 611 c, t dbSNP:190432371
612 612 a, g, t dbSNP:762623799
614 614 a, g dbSNP:752296357
623 623 c, g dbSNP:764773654
625 625 a, g dbSNP:759123413
630 630 c, t dbSNP:775997908
631 631 a, g dbSNP:768018632
640 640 c, t dbSNP:771523560
646 646 a, g dbSNP:761026520
649 649 c, t dbSNP:773720929
655 655 a, g dbSNP:377424178
669 669 a, t dbSNP:758236381
673 673 c, t dbSNP:752455835
686 686 a, g dbSNP:765003978
696 696 -, c dbSNP:397509408
703 703 c, t dbSNP:201484943
704 704 a, g dbSNP:753397709
706 706 c, t dbSNP:765736374
717 717 a, g dbSNP:75329866
726 726 a, g dbSNP:761299232
754 754 a, t dbSNP:773810706
766 766 c, t dbSNP:186493032
767 767 a, g dbSNP:376327613
799 799 a, g dbSNP:774853486
809 809 c, t dbSNP:141619224
810 810 a, g dbSNP:768981981
816 816 g, t dbSNP:749414590
820 820 a, g dbSNP:2293417
824 824 c, t dbSNP:769712849
830 830 a, g dbSNP:745924628
839 839 c, t dbSNP:397509405
846 846 c, t dbSNP:772007304
847 847 a, g dbSNP:747447517
871 871 a, g dbSNP:748008985
876 876 a, g dbSNP:778796615
886 886 a, g dbSNP:374977780
889 889 a, g dbSNP:749090821
891 891 -, aga dbSNP:769002311
891 891 a, g dbSNP:542193901
913 913 a, g dbSNP:572351725
934 934 g, t dbSNP:750013337
939 939 a, g dbSNP:767080034
946 946 c, t dbSNP:769584665
947 947 a, g dbSNP:745448272
955 955 a, c dbSNP:780880269
971 971 c, g dbSNP:147883949
980 980 a, g dbSNP:751048883
984 984 c, g dbSNP:201158885
993 993 c, t dbSNP:758923998
1000 1000 a, g dbSNP:188037270
1006 1006 a, g dbSNP:753014603
1013 1013 c, t dbSNP:562702157
1018 1018 a, g dbSNP:759780963
1021 1021 a, g dbSNP:754006294
1023 1023 a, g dbSNP:766568737
1030 1030 a, c dbSNP:760713355
1037 1037 -, aag dbSNP:770456331
1046 1046 a, g dbSNP:372988818
1056 1056 c, t dbSNP:768536854
1057 1057 c, g, t dbSNP:141470385
1060 1060 a, g dbSNP:576652667
1061 1061 c, t dbSNP:769672368
1062 1062 a, g, t dbSNP:201577008
1076 1076 a, g dbSNP:770612142
1078 1078 c, t dbSNP:376628666
1079 1079 a, g dbSNP:140414666
1080 1080 c, t dbSNP:758831830
1087 1087 a, g dbSNP:753203502
1111 1111 c, t dbSNP:779268474
1112 1112 a, g dbSNP:755389218
1114 1114 a, g dbSNP:754175611
1115 1115 -, gag dbSNP:748967613
1119 1119 a, c dbSNP:766656583
1123 1123 a, g dbSNP:372423633
1126 1126 c, t dbSNP:750483952
1127 1127 a, g dbSNP:767569116
1130 1130 a, c, g dbSNP:377136485
1134 1134 a, g dbSNP:765235194
1136 1136 a, g dbSNP:759470808
1137 1137 c, t dbSNP:776552071
1141 1141 a, g dbSNP:372446330
1143 1143 c, t dbSNP:746602244
1149 1149 c, g dbSNP:367908836
1160 1160 c, t dbSNP:751700497
1163 1163 c, g, t dbSNP:267604854
1166 1166 a, g dbSNP:754993965
1191 1191 a, g dbSNP:151220618
1200 1200 -, aag dbSNP:765354113
1203 1203 a, g dbSNP:142193069
1206 1206 c, t dbSNP:766200637
1207 1207 a, g dbSNP:760555858
1208 1208 c, t dbSNP:750183985
1213 1213 c, t dbSNP:767262463
1219 1219 a, c, g dbSNP:773859296
1223 1223 a, c dbSNP:768116351
1225 1225 a, g dbSNP:148666451
1234 1234 a, g dbSNP:146475742
1240 1240 a, g dbSNP:370706896
1246 1246 c, t dbSNP:144057094
1247 1247 a, g dbSNP:746301638
1253 1253 a, g dbSNP:781353760
1257 1257 c, t dbSNP:771281023
1276 1276 c, t dbSNP:747192638
1288 1288 a, c dbSNP:573977743
1289 1289 c, t dbSNP:758595837
1290 1290 c, t dbSNP:376181802
1291 1291 a, c, g dbSNP:755995632
1297 1297 c, t dbSNP:377096761
1301 1301 a, g dbSNP:775907713
1310 1310 a, g dbSNP:767236696
1333 1333 c, t dbSNP:761485678
1334 1334 a, g dbSNP:751165188
1337 1337 c, g dbSNP:767835921
1343 1343 a, g, t dbSNP:139178605
1350 1350 a, g dbSNP:770346178
1355 1355 a, g, t dbSNP:62622817
1364 1364 g, t dbSNP:771369108
1368 1368 c, t dbSNP:747351773
1371 1371 a, g dbSNP:778178070
1376 1376 c, g dbSNP:772416345
1378 1378 a, g dbSNP:748321156
1393 1393 c, t dbSNP:534395995
1407 1407 -, a dbSNP:775639614
1409 1409 -, g dbSNP:776905514
1423 1423 a, g dbSNP:760055527
1432 1432 c, t dbSNP:774862028
1436 1436 a, g dbSNP:769253509
1446 1446 g, t dbSNP:573316871
1459 1459 c, t dbSNP:557837688
1464 1464 a, g dbSNP:539514874
1470 1470 c, t dbSNP:757412
1685 1685 a, g dbSNP:776210388
1768 1768 a, g dbSNP:550582424
1784 1784 a, c, g dbSNP:535778005
1788 1788 a, c, g dbSNP:568358022
1794 1794 g, t dbSNP:542441875
1801 1801 a, g dbSNP:139568831
1864 1864 c, t dbSNP:113506872
1871 1871 a, t dbSNP:188405051
1873 1873 g, t dbSNP:779872295
1879 1879 a, c dbSNP:758179973
1907 1907 c, t dbSNP:372151208
1926 1926 g, t dbSNP:564076970
1932 1932 a, g dbSNP:150549976
1947 1947 a, g dbSNP:754694128
2033 2033 c, g dbSNP:533219573
2046 2046 c, t dbSNP:562576477
2102 2102 c, t dbSNP:182837376
2135 2135 c, g dbSNP:745748205
2186 2186 c, t dbSNP:574036812
2215 2215 a, g dbSNP:142876327
2256 2256 c, t dbSNP:751562026
2263 2263 c, g dbSNP:540523189
2266 2266 c, t dbSNP:573409803
2294 2294 a, g dbSNP:766208903
2296 2296 a, c dbSNP:558036657
2302 2302 a, g dbSNP:377752545
2373 2373 a, g dbSNP:191521736
2397 2397 c, t dbSNP:575390165
2415 2415 -, ta dbSNP:746367094
2416 2416 -, a dbSNP:3033073
2416 2416 -, a dbSNP:397817802
2416 2416 a, t dbSNP:557040547
2425 2425 -, a dbSNP:761634782

Target ORF information:

RefSeq Version NM_003079
Organism Homo sapiens (human)
Definition Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003079

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGTCAAAAA GACCATCTTA TGCCCCACCT CCCACCCCAG CTCCTGCAAC ACAAATGCCC 
AGCACACCAG GGTTTGTGGG ATACAATCCA TACAGTCATC TCGCCTACAA CAACTACAGG
CTGGGAGGGA ACCCGGGCAC CAACAGCCGG GTCACGGCAT CCTCTGGTAT CACGATTCCA
AAACCCCCAA AGCCACCAGA TAAGCCGCTG ATGCCCTACA TGAGGTACAG CAGAAAGGTC
TGGGACCAAG TAAAGGCTTC CAACCCTGAC CTAAAGTTGT GGGAGATTGG CAAGATTATT
GGTGGCATGT GGCGAGATCT CACTGATGAA GAAAAACAAG AATATTTAAA CGAATACGAA
GCAGAAAAGA TAGAGTACAA TGAATCTATG AAGGCCTATC ATAATTCCCC CGCGTACCTT
GCTTACATAA ATGCAAAAAG TCGTGCAGAA GCTGCTTTAG AGGAAGAAAG TCGACAGAGA
CAATCTCGCA TGGAGAAAGG AGAACCGTAC ATGAGCATTC AGCCTGCTGA AGATCCAGAT
GATTATGATG ATGGCTTTTC AATGAAGCAT ACAGCCACCG CCCGTTTCCA GAGAAACCAC
CGCCTCATCA GTGAAATTCT TAGTGAGAGT GTGGTGCCAG ACGTTCGGTC AGTTGTCACA
ACAGCTAGAA TGCAGGTCCT CAAACGGCAG GTCCAGTCCT TAATGGTTCA TCAGCGAAAA
CTAGAAGCTG AACTTCTTCA AATAGAGGAA CGACACCAGG AGAAGAAGAG GAAATTCCTG
GAAAGCACAG ATTCATTTAA CAATGAACTT AAAAGGTTGT GCGGTCTGAA AGTAGAAGTG
GATATGGAGA AAATTGCAGC TGAGATTGCA CAGGCAGAGG AACAGGCCCG CAAAAGGCAG
GAGGAAAGGG AGAAGGAGGC CGCAGAGCAA GCTGAGCGCA GTCAGAGCAG CATCGTTCCT
GAGGAAGAAC AAGCAGCTAA CAAAGGCGAG GAGAAGAAAG ACGACGAGAA CATTCCGATG
GAGACAGAGG AGACACACCT TGAAGAAACA ACAGAGAGCC AACAGAATGG TGAAGAAGGC
ACGTCTACTC CTGAGGACAA GGAGAGTGGG CAGGAGGGGG TCGACAGTAT GGCAGAGGAA
GGAACCAGTG ATAGTAACAC TGGCTCGGAG AGCAACAGTG CAACAGTGGA GGAGCCACCA
ACAGATCCCA TACCAGAAGA TGAGAAAAAA GAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.