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SNCA cDNA ORF clone, Homo sapiens (human)

Gene Symbol SNCA
Entrez Gene ID 6622
Full Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms NACP, PARK1, PARK4, PD1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. lac of sum
Disorder MIM:

163890

Disorder Html: Parkinson disease 4, 605543 (3); Dementia, Lewy body, 127750 (3);





The following SNCA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNCA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60654 XM_011532203 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu60654 XM_011532204 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu60654 XM_011532205 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu60654 XM_011532206 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu60654 XM_011532207 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu23545 XM_011532208 PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00
OHu23545 NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00
OHu24073 NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00
OHu23545 NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00
OHu23545 NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu60654
Accession Version XM_011532203.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530505.1
CDS293..805
Misc Feature(1)293..>598(+)
Translation
Position Chain Variation Link
17 17 c, g dbSNP:541631085
19 19 a, g dbSNP:372025454
28 28 c, g dbSNP:781415581
37 37 a, g dbSNP:559345055
41 41 a, t dbSNP:541308395
42 42 a, c dbSNP:767878442
63 63 a, t dbSNP:576771705
74 74 c, g dbSNP:757451373
78 78 a, g dbSNP:558503723
88 88 c, t dbSNP:543444318
90 90 a, g dbSNP:576092144
100 100 c, g dbSNP:374236518
149 149 c, g dbSNP:751744281
155 155 c, g dbSNP:555070398
158 158 c, g dbSNP:536401787
159 159 c, g dbSNP:566275194
160 160 -, g dbSNP:549379407
164 164 a, g dbSNP:367902113
166 166 c, t dbSNP:764272411
168 168 a, c dbSNP:186166223
203 203 a, g dbSNP:539338282
249 249 a, g dbSNP:571999989
259 259 a, c dbSNP:182006507
266 266 a, c dbSNP:530541543
267 267 a, g dbSNP:569601627
270 270 c, t dbSNP:769265023
284 284 -, aatt dbSNP:769191615
286 286 a, g dbSNP:745412490
288 288 c, t dbSNP:780787014
299 299 a, g dbSNP:770296707
301 301 a, g dbSNP:370989462
304 304 a, c dbSNP:777339905
319 319 a, g dbSNP:758254766
331 331 a, c, g dbSNP:774124882
345 345 c, g dbSNP:752472160
351 351 a, g dbSNP:778867145
358 358 a, c dbSNP:754909792
368 368 a, g dbSNP:753674628
380 380 c, g dbSNP:104893878
391 391 a, g dbSNP:766497794
397 397 a, g dbSNP:768334864
401 401 a, g dbSNP:750745088
409 409 g, t dbSNP:372201440
412 412 a, g dbSNP:767842851
414 414 a, g dbSNP:750512067
428 428 a, g dbSNP:104893875
439 439 a, g dbSNP:141859659
442 442 g, t dbSNP:201106962
444 444 a, g dbSNP:431905511
448 448 g, t dbSNP:148108612
449 449 a, g dbSNP:104893877
450 450 c, g, t dbSNP:542171324
452 452 a, g dbSNP:374953392
458 458 a, g dbSNP:751833438
469 469 c, t dbSNP:764216470
481 481 a, g dbSNP:371864975
495 495 a, g dbSNP:752981956
499 499 a, g dbSNP:765809605
502 502 a, g dbSNP:529511227
504 504 c, t dbSNP:777070190
507 507 c, t dbSNP:767026129
508 508 a, g dbSNP:144758871
509 509 g, t dbSNP:774113587
517 517 a, t dbSNP:149401968
535 535 a, g dbSNP:568436589
538 538 a, g dbSNP:775179895
543 543 g, t dbSNP:386352363
563 563 a, g dbSNP:769664191
564 564 a, c dbSNP:745815563
579 579 a, g dbSNP:548523899
588 588 a, g dbSNP:757477802
590 590 c, t dbSNP:138969470
625 625 g, t dbSNP:748517599
632 632 g, t dbSNP:779330854
646 646 a, g dbSNP:557671924
710 710 g, t dbSNP:568285340
730 730 -, t dbSNP:546799104
758 758 c, t dbSNP:149189004
784 784 a, g dbSNP:534733377
786 786 a, g dbSNP:10014396
812 812 a, c dbSNP:111869921
819 819 c, t dbSNP:773067743
838 838 a, g dbSNP:535452028
849 849 a, t dbSNP:371758130
858 858 -, a dbSNP:140695649
874 874 a, g dbSNP:147108251
888 888 -, a dbSNP:397879351
888 888 a, g dbSNP:78621961
899 899 -, a dbSNP:35277735
904 904 c, t dbSNP:10002435
906 906 c, t dbSNP:528577514
913 913 c, g dbSNP:367567480

Target ORF information:

RefSeq Version XM_011532203
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532203

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60654
Accession Version XM_011532204.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530506.1
CDS272..784
Misc Feature(1)272..>577(+)
Translation
Position Chain Variation Link
9 9 a, g dbSNP:571999989
19 19 a, c dbSNP:182006507
26 26 a, c dbSNP:530541543
27 27 a, g dbSNP:569601627
34 34 a, g dbSNP:548276692
42 42 c, t dbSNP:545809130
68 68 c, g dbSNP:35064456
90 90 a, g dbSNP:540893098
159 159 a, g dbSNP:376844427
182 182 a, t dbSNP:532257366
191 191 a, t dbSNP:564849543
192 192 -, t dbSNP:201360644
192 192 aa, tt dbSNP:71594901
192 192 a, t dbSNP:2245804
193 193 -, t dbSNP:200200161
193 193 a, t dbSNP:2583986
194 194 a, t dbSNP:554728728
198 198 -, a dbSNP:3833895
238 238 c, g dbSNP:543101751
240 240 g, t dbSNP:530627289
249 249 c, t dbSNP:769265023
263 263 -, aatt dbSNP:769191615
265 265 a, g dbSNP:745412490
267 267 c, t dbSNP:780787014
278 278 a, g dbSNP:770296707
280 280 a, g dbSNP:370989462
283 283 a, c dbSNP:777339905
298 298 a, g dbSNP:758254766
310 310 a, c, g dbSNP:774124882
324 324 c, g dbSNP:752472160
330 330 a, g dbSNP:778867145
337 337 a, c dbSNP:754909792
347 347 a, g dbSNP:753674628
359 359 c, g dbSNP:104893878
370 370 a, g dbSNP:766497794
376 376 a, g dbSNP:768334864
380 380 a, g dbSNP:750745088
388 388 g, t dbSNP:372201440
391 391 a, g dbSNP:767842851
393 393 a, g dbSNP:750512067
407 407 a, g dbSNP:104893875
418 418 a, g dbSNP:141859659
421 421 g, t dbSNP:201106962
423 423 a, g dbSNP:431905511
427 427 g, t dbSNP:148108612
428 428 a, g dbSNP:104893877
429 429 c, g, t dbSNP:542171324
431 431 a, g dbSNP:374953392
437 437 a, g dbSNP:751833438
448 448 c, t dbSNP:764216470
460 460 a, g dbSNP:371864975
474 474 a, g dbSNP:752981956
478 478 a, g dbSNP:765809605
481 481 a, g dbSNP:529511227
483 483 c, t dbSNP:777070190
486 486 c, t dbSNP:767026129
487 487 a, g dbSNP:144758871
488 488 g, t dbSNP:774113587
496 496 a, t dbSNP:149401968
514 514 a, g dbSNP:568436589
517 517 a, g dbSNP:775179895
522 522 g, t dbSNP:386352363
542 542 a, g dbSNP:769664191
543 543 a, c dbSNP:745815563
558 558 a, g dbSNP:548523899
567 567 a, g dbSNP:757477802
569 569 c, t dbSNP:138969470
604 604 g, t dbSNP:748517599
611 611 g, t dbSNP:779330854
625 625 a, g dbSNP:557671924
689 689 g, t dbSNP:568285340
709 709 -, t dbSNP:546799104
737 737 c, t dbSNP:149189004
763 763 a, g dbSNP:534733377
765 765 a, g dbSNP:10014396
791 791 a, c dbSNP:111869921
798 798 c, t dbSNP:773067743
817 817 a, g dbSNP:535452028
828 828 a, t dbSNP:371758130
837 837 -, a dbSNP:140695649
853 853 a, g dbSNP:147108251
867 867 -, a dbSNP:397879351
867 867 a, g dbSNP:78621961
878 878 -, a dbSNP:35277735
883 883 c, t dbSNP:10002435
885 885 c, t dbSNP:528577514
892 892 c, g dbSNP:367567480

Target ORF information:

RefSeq Version XM_011532204
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532204

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60654
Accession Version XM_011532205.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530507.1
CDS89..601
Misc Feature(1)89..>394(+)
Translation
Position Chain Variation Link
28 28 c, t dbSNP:74786912
49 49 c, t dbSNP:190233303
66 66 c, t dbSNP:769265023
80 80 -, aatt dbSNP:769191615
82 82 a, g dbSNP:745412490
84 84 c, t dbSNP:780787014
95 95 a, g dbSNP:770296707
97 97 a, g dbSNP:370989462
100 100 a, c dbSNP:777339905
115 115 a, g dbSNP:758254766
127 127 a, c, g dbSNP:774124882
141 141 c, g dbSNP:752472160
147 147 a, g dbSNP:778867145
154 154 a, c dbSNP:754909792
164 164 a, g dbSNP:753674628
176 176 c, g dbSNP:104893878
187 187 a, g dbSNP:766497794
193 193 a, g dbSNP:768334864
197 197 a, g dbSNP:750745088
205 205 g, t dbSNP:372201440
208 208 a, g dbSNP:767842851
210 210 a, g dbSNP:750512067
224 224 a, g dbSNP:104893875
235 235 a, g dbSNP:141859659
238 238 g, t dbSNP:201106962
240 240 a, g dbSNP:431905511
244 244 g, t dbSNP:148108612
245 245 a, g dbSNP:104893877
246 246 c, g, t dbSNP:542171324
248 248 a, g dbSNP:374953392
254 254 a, g dbSNP:751833438
265 265 c, t dbSNP:764216470
277 277 a, g dbSNP:371864975
291 291 a, g dbSNP:752981956
295 295 a, g dbSNP:765809605
298 298 a, g dbSNP:529511227
300 300 c, t dbSNP:777070190
303 303 c, t dbSNP:767026129
304 304 a, g dbSNP:144758871
305 305 g, t dbSNP:774113587
313 313 a, t dbSNP:149401968
331 331 a, g dbSNP:568436589
334 334 a, g dbSNP:775179895
339 339 g, t dbSNP:386352363
359 359 a, g dbSNP:769664191
360 360 a, c dbSNP:745815563
375 375 a, g dbSNP:548523899
384 384 a, g dbSNP:757477802
386 386 c, t dbSNP:138969470
421 421 g, t dbSNP:748517599
428 428 g, t dbSNP:779330854
442 442 a, g dbSNP:557671924
506 506 g, t dbSNP:568285340
526 526 -, t dbSNP:546799104
554 554 c, t dbSNP:149189004
580 580 a, g dbSNP:534733377
582 582 a, g dbSNP:10014396
608 608 a, c dbSNP:111869921
615 615 c, t dbSNP:773067743
634 634 a, g dbSNP:535452028
645 645 a, t dbSNP:371758130
654 654 -, a dbSNP:140695649
670 670 a, g dbSNP:147108251
684 684 -, a dbSNP:397879351
684 684 a, g dbSNP:78621961
695 695 -, a dbSNP:35277735
700 700 c, t dbSNP:10002435
702 702 c, t dbSNP:528577514
709 709 c, g dbSNP:367567480

Target ORF information:

RefSeq Version XM_011532205
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532205

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60654
Accession Version XM_011532206.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530508.1
CDS121..633
Misc Feature(1)121..>426(+)
Translation
Position Chain Variation Link
1 1 a, g dbSNP:559345055
5 5 a, t dbSNP:541308395
6 6 a, c dbSNP:767878442
27 27 a, t dbSNP:576771705
38 38 c, g dbSNP:757451373
42 42 a, g dbSNP:558503723
52 52 c, t dbSNP:543444318
54 54 a, g dbSNP:576092144
64 64 c, g dbSNP:374236518
98 98 c, t dbSNP:769265023
112 112 -, aatt dbSNP:769191615
114 114 a, g dbSNP:745412490
116 116 c, t dbSNP:780787014
127 127 a, g dbSNP:770296707
129 129 a, g dbSNP:370989462
132 132 a, c dbSNP:777339905
147 147 a, g dbSNP:758254766
159 159 a, c, g dbSNP:774124882
173 173 c, g dbSNP:752472160
179 179 a, g dbSNP:778867145
186 186 a, c dbSNP:754909792
196 196 a, g dbSNP:753674628
208 208 c, g dbSNP:104893878
219 219 a, g dbSNP:766497794
225 225 a, g dbSNP:768334864
229 229 a, g dbSNP:750745088
237 237 g, t dbSNP:372201440
240 240 a, g dbSNP:767842851
242 242 a, g dbSNP:750512067
256 256 a, g dbSNP:104893875
267 267 a, g dbSNP:141859659
270 270 g, t dbSNP:201106962
272 272 a, g dbSNP:431905511
276 276 g, t dbSNP:148108612
277 277 a, g dbSNP:104893877
278 278 c, g, t dbSNP:542171324
280 280 a, g dbSNP:374953392
286 286 a, g dbSNP:751833438
297 297 c, t dbSNP:764216470
309 309 a, g dbSNP:371864975
323 323 a, g dbSNP:752981956
327 327 a, g dbSNP:765809605
330 330 a, g dbSNP:529511227
332 332 c, t dbSNP:777070190
335 335 c, t dbSNP:767026129
336 336 a, g dbSNP:144758871
337 337 g, t dbSNP:774113587
345 345 a, t dbSNP:149401968
363 363 a, g dbSNP:568436589
366 366 a, g dbSNP:775179895
371 371 g, t dbSNP:386352363
391 391 a, g dbSNP:769664191
392 392 a, c dbSNP:745815563
407 407 a, g dbSNP:548523899
416 416 a, g dbSNP:757477802
418 418 c, t dbSNP:138969470
453 453 g, t dbSNP:748517599
460 460 g, t dbSNP:779330854
474 474 a, g dbSNP:557671924
538 538 g, t dbSNP:568285340
558 558 -, t dbSNP:546799104
586 586 c, t dbSNP:149189004
612 612 a, g dbSNP:534733377
614 614 a, g dbSNP:10014396
640 640 a, c dbSNP:111869921
647 647 c, t dbSNP:773067743
666 666 a, g dbSNP:535452028
677 677 a, t dbSNP:371758130
686 686 -, a dbSNP:140695649
702 702 a, g dbSNP:147108251
716 716 -, a dbSNP:397879351
716 716 a, g dbSNP:78621961
727 727 -, a dbSNP:35277735
732 732 c, t dbSNP:10002435
734 734 c, t dbSNP:528577514
741 741 c, g dbSNP:367567480

Target ORF information:

RefSeq Version XM_011532206
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532206

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu60654
Accession Version XM_011532207.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 513bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530509.1
CDS108..620
Misc Feature(1)108..>413(+)
Translation
Position Chain Variation Link
48 48 a, g dbSNP:2870027
51 51 c, t dbSNP:1372519
66 66 g, t dbSNP:1372518
75 75 a, c dbSNP:751965725
78 78 c, t dbSNP:746055007
85 85 c, t dbSNP:769265023
99 99 -, aatt dbSNP:769191615
101 101 a, g dbSNP:745412490
103 103 c, t dbSNP:780787014
114 114 a, g dbSNP:770296707
116 116 a, g dbSNP:370989462
119 119 a, c dbSNP:777339905
134 134 a, g dbSNP:758254766
146 146 a, c, g dbSNP:774124882
160 160 c, g dbSNP:752472160
166 166 a, g dbSNP:778867145
173 173 a, c dbSNP:754909792
183 183 a, g dbSNP:753674628
195 195 c, g dbSNP:104893878
206 206 a, g dbSNP:766497794
212 212 a, g dbSNP:768334864
216 216 a, g dbSNP:750745088
224 224 g, t dbSNP:372201440
227 227 a, g dbSNP:767842851
229 229 a, g dbSNP:750512067
243 243 a, g dbSNP:104893875
254 254 a, g dbSNP:141859659
257 257 g, t dbSNP:201106962
259 259 a, g dbSNP:431905511
263 263 g, t dbSNP:148108612
264 264 a, g dbSNP:104893877
265 265 c, g, t dbSNP:542171324
267 267 a, g dbSNP:374953392
273 273 a, g dbSNP:751833438
284 284 c, t dbSNP:764216470
296 296 a, g dbSNP:371864975
310 310 a, g dbSNP:752981956
314 314 a, g dbSNP:765809605
317 317 a, g dbSNP:529511227
319 319 c, t dbSNP:777070190
322 322 c, t dbSNP:767026129
323 323 a, g dbSNP:144758871
324 324 g, t dbSNP:774113587
332 332 a, t dbSNP:149401968
350 350 a, g dbSNP:568436589
353 353 a, g dbSNP:775179895
358 358 g, t dbSNP:386352363
378 378 a, g dbSNP:769664191
379 379 a, c dbSNP:745815563
394 394 a, g dbSNP:548523899
403 403 a, g dbSNP:757477802
405 405 c, t dbSNP:138969470
440 440 g, t dbSNP:748517599
447 447 g, t dbSNP:779330854
461 461 a, g dbSNP:557671924
525 525 g, t dbSNP:568285340
545 545 -, t dbSNP:546799104
573 573 c, t dbSNP:149189004
599 599 a, g dbSNP:534733377
601 601 a, g dbSNP:10014396
627 627 a, c dbSNP:111869921
634 634 c, t dbSNP:773067743
653 653 a, g dbSNP:535452028
664 664 a, t dbSNP:371758130
673 673 -, a dbSNP:140695649
689 689 a, g dbSNP:147108251
703 703 -, a dbSNP:397879351
703 703 a, g dbSNP:78621961
714 714 -, a dbSNP:35277735
719 719 c, t dbSNP:10002435
721 721 c, t dbSNP:528577514
728 728 c, g dbSNP:367567480

Target ORF information:

RefSeq Version XM_011532207
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532207

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAAGC ATCCAAAATA CAAACCATCT AAGAGGCAAG AAAATGTCGT GATGTTCCTA
GTGCAAGTTA AAAAGATTTG CTTTCCTCAA GTCGGAAAGC CCTTCTCATT TTTGAGGTTT
TTTTCTTCTT TTTTTTTTCA AGTGAAAGCA TTTTGGAGGA GTCAATATCC ATCTTTAAAG
GTAGCCAGGT CACATGTATA CATATGTAAC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23545
Accession Version XM_011532208.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011530510.1
CDS121..543
Misc Feature(1)121..516(+)
Translation
Position Chain Variation Link
1 1 a, g dbSNP:559345055
5 5 a, t dbSNP:541308395
6 6 a, c dbSNP:767878442
27 27 a, t dbSNP:576771705
38 38 c, g dbSNP:757451373
42 42 a, g dbSNP:558503723
52 52 c, t dbSNP:543444318
54 54 a, g dbSNP:576092144
64 64 c, g dbSNP:374236518
98 98 c, t dbSNP:769265023
112 112 -, aatt dbSNP:769191615
114 114 a, g dbSNP:745412490
116 116 c, t dbSNP:780787014
127 127 a, g dbSNP:770296707
129 129 a, g dbSNP:370989462
132 132 a, c dbSNP:777339905
147 147 a, g dbSNP:758254766
159 159 a, c, g dbSNP:774124882
173 173 c, g dbSNP:752472160
179 179 a, g dbSNP:778867145
186 186 a, c dbSNP:754909792
196 196 a, g dbSNP:753674628
208 208 c, g dbSNP:104893878
219 219 a, g dbSNP:766497794
225 225 a, g dbSNP:768334864
229 229 a, g dbSNP:750745088
237 237 g, t dbSNP:372201440
240 240 a, g dbSNP:767842851
242 242 a, g dbSNP:750512067
256 256 a, g dbSNP:104893875
267 267 a, g dbSNP:141859659
270 270 g, t dbSNP:201106962
272 272 a, g dbSNP:431905511
276 276 g, t dbSNP:148108612
277 277 a, g dbSNP:104893877
278 278 c, g, t dbSNP:542171324
280 280 a, g dbSNP:374953392
286 286 a, g dbSNP:751833438
297 297 c, t dbSNP:764216470
309 309 a, g dbSNP:371864975
323 323 a, g dbSNP:752981956
327 327 a, g dbSNP:765809605
330 330 a, g dbSNP:529511227
332 332 c, t dbSNP:777070190
335 335 c, t dbSNP:767026129
336 336 a, g dbSNP:144758871
337 337 g, t dbSNP:774113587
345 345 a, t dbSNP:149401968
363 363 a, g dbSNP:568436589
366 366 a, g dbSNP:775179895
371 371 g, t dbSNP:386352363
391 391 a, g dbSNP:769664191
392 392 a, c dbSNP:745815563
407 407 a, g dbSNP:548523899
416 416 a, g dbSNP:757477802
418 418 c, t dbSNP:138969470
429 429 c, t dbSNP:759452333
434 434 a, c dbSNP:776535649
462 462 a, c dbSNP:770804878
466 466 a, g dbSNP:372101729
467 467 c, t dbSNP:760548842
469 469 a, c, t dbSNP:145138372
471 471 a, c, t dbSNP:143084604
478 478 a, c dbSNP:779158137
482 482 a, g dbSNP:768838511
485 485 a, g dbSNP:749476922
486 486 c, t dbSNP:780419569
487 487 a, g dbSNP:200056149
495 495 c, t dbSNP:367556974
501 501 a, g dbSNP:191055637
502 502 a, c dbSNP:750899874
514 514 a, g dbSNP:749526106
518 518 a, g dbSNP:377006107
528 528 c, t dbSNP:76642636
532 532 c, t dbSNP:375682339
533 533 a, c dbSNP:746232417
539 539 c, t dbSNP:781595227
540 540 c, g dbSNP:757748949
562 562 c, g dbSNP:747474608
566 566 a, c dbSNP:778588756
581 581 a, c dbSNP:754479691
583 583 a, g dbSNP:753544938
586 586 -, g dbSNP:755608841
587 587 c, t dbSNP:779277002
593 593 a, c dbSNP:755913681
599 599 c, g dbSNP:778443752
620 620 a, c dbSNP:145304567
624 624 g, t dbSNP:373801428
626 626 c, t dbSNP:370319708
654 654 a, t dbSNP:772716317
655 655 a, g dbSNP:748631342
659 659 c, g, t dbSNP:144511886
660 660 a, g dbSNP:184023281
661 661 a, g dbSNP:560702695
682 682 g, t dbSNP:10024743
705 705 c, t dbSNP:578250733
715 715 c, t dbSNP:192194319
716 716 a, g dbSNP:79726680
717 717 c, g dbSNP:187958987
737 737 c, t dbSNP:34825021
745 745 c, t dbSNP:185476145
746 746 a, g dbSNP:35716318
751 751 c, t dbSNP:565855781
792 792 a, g dbSNP:553599518
816 816 c, t dbSNP:193289281
825 825 a, t dbSNP:571218440
856 856 g, t dbSNP:549732620
866 866 c, t dbSNP:755315517
919 919 c, t dbSNP:35733299
966 966 a, g dbSNP:567582133
993 993 a, c dbSNP:754013370
1007 1007 a, c dbSNP:183204610
1010 1010 c, g dbSNP:533910909
1013 1013 g, t dbSNP:780286202
1029 1029 a, t dbSNP:370791472
1044 1044 c, t dbSNP:17016074
1045 1045 a, g dbSNP:560621582
1123 1123 -, atttt dbSNP:756360541
1129 1129 a, g dbSNP:545627654
1136 1136 a, c dbSNP:35101723
1193 1193 a, t dbSNP:563195772
1197 1197 c, t dbSNP:544604827
1228 1228 a, g dbSNP:575975134
1296 1296 a, c dbSNP:750566704
1301 1301 c, t dbSNP:554306228
1319 1319 g, t dbSNP:373978617
1341 1341 c, g dbSNP:571813266
1365 1365 a, g dbSNP:35343095
1393 1393 a, g dbSNP:553513542
1395 1395 g, t dbSNP:150645039
1403 1403 a, t dbSNP:577490090
1436 1436 cgt, tgc dbSNP:386677144
1436 1436 c, t dbSNP:356165
1437 1437 a, g dbSNP:192179063
1438 1438 c, t dbSNP:187002185
1464 1464 a, g dbSNP:148246747
1533 1533 a, g dbSNP:532997483
1545 1545 g, t dbSNP:182722435
1559 1559 c, t dbSNP:566987021
1576 1576 c, t dbSNP:550521282
1590 1590 g, t dbSNP:532025477
1635 1635 -, a dbSNP:750347645
1635 1635 -, a dbSNP:571454522
1637 1637 -, t dbSNP:143570143
1645 1645 c, t dbSNP:561544802

Target ORF information:

RefSeq Version XM_011532208
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant X6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532208

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23545
Accession Version NM_000345.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform NACP140
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI815523.1, BC108275.1 and AC097478.2. This sequence is a reference standard in the RefSeqGene project. On Mar 26, 2009 this sequence version replaced gi:6806896. Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (1, also known as NACP140) is the longest transcript and encodes the longer isoform (NACP140). Variants 1, 2, and 3 all encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108275.1, L08850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000336.1
CDS264..686
Misc Feature(1)246..248(+)
Misc Feature(2)264..659(+)
Misc Feature(3)264..266(+)
Misc Feature(4)297..299(+)
Misc Feature(5)321..464(+)
Misc Feature(6)522..524(+)
Misc Feature(7)531..533(+)
Misc Feature(8)636..638(+)
Misc Feature(9)645..647(+)
Misc Feature(10)645..647(+)
Misc Feature(11)645..647(+)
Misc Feature(12)645..647(+)
Misc Feature(13)645..647(+)
Misc Feature(14)648..650(+)
Misc Feature(15)657..659(+)
Misc Feature(16)657..659(+)
Misc Feature(17)657..659(+)
Misc Feature(18)657..659(+)
Misc Feature(19)657..659(+)
Misc Feature(20)669..671(+)
Misc Feature(21)678..680(+)
Exon (1)1..238
Gene:SNCA
Gene Synonym:
Exon (2)239..384
Gene:SNCA
Gene Synonym:
Exon (3)385..426
Gene:SNCA
Gene Synonym:
Exon (4)427..569
Gene:SNCA
Gene Synonym:
Exon (5)570..653
Gene:SNCA
Gene Synonym:
Exon (6)654..3215
Gene:SNCA
Gene Synonym:
Translation
Position Chain Variation Link
8 8 a, g dbSNP:559345055
12 12 a, t dbSNP:541308395
13 13 a, c dbSNP:767878442
34 34 a, t dbSNP:576771705
45 45 c, g dbSNP:757451373
49 49 a, g dbSNP:558503723
59 59 c, t dbSNP:543444318
61 61 a, g dbSNP:576092144
71 71 c, g dbSNP:374236518
120 120 c, g dbSNP:751744281
126 126 c, g dbSNP:555070398
129 129 c, g dbSNP:536401787
130 130 c, g dbSNP:566275194
131 131 -, g dbSNP:549379407
135 135 a, g dbSNP:367902113
137 137 c, t dbSNP:764272411
139 139 a, c dbSNP:186166223
174 174 a, g dbSNP:539338282
220 220 a, g dbSNP:571999989
230 230 a, c dbSNP:182006507
237 237 a, c dbSNP:530541543
238 238 a, g dbSNP:569601627
241 241 c, t dbSNP:769265023
255 255 -, aatt dbSNP:769191615
257 257 a, g dbSNP:745412490
259 259 c, t dbSNP:780787014
270 270 a, g dbSNP:770296707
272 272 a, g dbSNP:370989462
275 275 a, c dbSNP:777339905
290 290 a, g dbSNP:758254766
302 302 a, c, g dbSNP:774124882
316 316 c, g dbSNP:752472160
322 322 a, g dbSNP:778867145
329 329 a, c dbSNP:754909792
339 339 a, g dbSNP:753674628
351 351 c, g dbSNP:104893878
362 362 a, g dbSNP:766497794
368 368 a, g dbSNP:768334864
372 372 a, g dbSNP:750745088
380 380 g, t dbSNP:372201440
383 383 a, g dbSNP:767842851
385 385 a, g dbSNP:750512067
399 399 a, g dbSNP:104893875
410 410 a, g dbSNP:141859659
413 413 g, t dbSNP:201106962
415 415 a, g dbSNP:431905511
419 419 g, t dbSNP:148108612
420 420 a, g dbSNP:104893877
421 421 c, g, t dbSNP:542171324
423 423 a, g dbSNP:374953392
429 429 a, g dbSNP:751833438
440 440 c, t dbSNP:764216470
452 452 a, g dbSNP:371864975
466 466 a, g dbSNP:752981956
470 470 a, g dbSNP:765809605
473 473 a, g dbSNP:529511227
475 475 c, t dbSNP:777070190
478 478 c, t dbSNP:767026129
479 479 a, g dbSNP:144758871
480 480 g, t dbSNP:774113587
488 488 a, t dbSNP:149401968
506 506 a, g dbSNP:568436589
509 509 a, g dbSNP:775179895
514 514 g, t dbSNP:386352363
534 534 a, g dbSNP:769664191
535 535 a, c dbSNP:745815563
550 550 a, g dbSNP:548523899
559 559 a, g dbSNP:757477802
561 561 c, t dbSNP:138969470
572 572 c, t dbSNP:759452333
577 577 a, c dbSNP:776535649
605 605 a, c dbSNP:770804878
609 609 a, g dbSNP:372101729
610 610 c, t dbSNP:760548842
612 612 a, c, t dbSNP:145138372
614 614 a, c, t dbSNP:143084604
621 621 a, c dbSNP:779158137
625 625 a, g dbSNP:768838511
628 628 a, g dbSNP:749476922
629 629 c, t dbSNP:780419569
630 630 a, g dbSNP:200056149
638 638 c, t dbSNP:367556974
644 644 a, g dbSNP:191055637
645 645 a, c dbSNP:750899874
657 657 a, g dbSNP:749526106
661 661 a, g dbSNP:377006107
671 671 c, t dbSNP:76642636
675 675 c, t dbSNP:375682339
676 676 a, c dbSNP:746232417
682 682 c, t dbSNP:781595227
683 683 c, g dbSNP:757748949
705 705 c, g dbSNP:747474608
709 709 a, c dbSNP:778588756
724 724 a, c dbSNP:754479691
726 726 a, g dbSNP:753544938
729 729 -, g dbSNP:755608841
730 730 c, t dbSNP:779277002
736 736 a, c dbSNP:755913681
742 742 c, g dbSNP:778443752
763 763 a, c dbSNP:145304567
767 767 g, t dbSNP:373801428
769 769 c, t dbSNP:370319708
797 797 a, t dbSNP:772716317
798 798 a, g dbSNP:748631342
802 802 c, g, t dbSNP:144511886
803 803 a, g dbSNP:184023281
804 804 a, g dbSNP:560702695
825 825 g, t dbSNP:10024743
848 848 c, t dbSNP:578250733
858 858 c, t dbSNP:192194319
859 859 a, g dbSNP:79726680
860 860 c, g dbSNP:187958987
880 880 c, t dbSNP:34825021
888 888 c, t dbSNP:185476145
889 889 a, g dbSNP:35716318
894 894 c, t dbSNP:565855781
935 935 a, g dbSNP:553599518
959 959 c, t dbSNP:193289281
968 968 a, t dbSNP:571218440
999 999 g, t dbSNP:549732620
1009 1009 c, t dbSNP:755315517
1062 1062 c, t dbSNP:35733299
1109 1109 a, g dbSNP:567582133
1136 1136 a, c dbSNP:754013370
1150 1150 a, c dbSNP:183204610
1153 1153 c, g dbSNP:533910909
1156 1156 g, t dbSNP:780286202
1172 1172 a, t dbSNP:370791472
1187 1187 c, t dbSNP:17016074
1188 1188 a, g dbSNP:560621582
1266 1266 -, atttt dbSNP:756360541
1272 1272 a, g dbSNP:545627654
1279 1279 a, c dbSNP:35101723
1336 1336 a, t dbSNP:563195772
1340 1340 c, t dbSNP:544604827
1371 1371 a, g dbSNP:575975134
1439 1439 a, c dbSNP:750566704
1444 1444 c, t dbSNP:554306228
1462 1462 g, t dbSNP:373978617
1484 1484 c, g dbSNP:571813266
1508 1508 a, g dbSNP:35343095
1536 1536 a, g dbSNP:553513542
1538 1538 g, t dbSNP:150645039
1546 1546 a, t dbSNP:577490090
1579 1579 cgt, tgc dbSNP:386677144
1579 1579 c, t dbSNP:356165
1580 1580 a, g dbSNP:192179063
1581 1581 c, t dbSNP:187002185
1607 1607 a, g dbSNP:148246747
1676 1676 a, g dbSNP:532997483
1688 1688 g, t dbSNP:182722435
1702 1702 c, t dbSNP:566987021
1719 1719 c, t dbSNP:550521282
1733 1733 g, t dbSNP:532025477
1778 1778 -, a dbSNP:750347645
1778 1778 -, a dbSNP:571454522
1780 1780 -, t dbSNP:143570143
1788 1788 c, t dbSNP:561544802
1857 1857 c, t dbSNP:551974660
1895 1895 a, g dbSNP:533541220
1910 1910 a, g dbSNP:147204331
1933 1933 a, t dbSNP:77964369
1945 1945 -, tc dbSNP:5860180
1959 1959 -, tctc dbSNP:761782877
1959 1959 -, tc dbSNP:765487318
1960 1960 -, ctct dbSNP:141457381
1960 1960 -, ct dbSNP:533408267
1962 1962 -, ct dbSNP:35270750
1962 1962 c, t dbSNP:201351609
1966 1966 c, t dbSNP:200268319
1973 1973 a, g dbSNP:377356638
1975 1975 c, t dbSNP:527798413
1978 1978 c, t dbSNP:1987877
1978 1978 -, ttttt dbSNP:397994464
1995 1995 -, tttt, ttttt, tttttt dbSNP:777296100
2092 2092 a, g dbSNP:529496201
2114 2114 a, g dbSNP:767553862
2163 2163 c, t dbSNP:560896156
2169 2169 a, t dbSNP:758398107
2176 2176 c, t dbSNP:752617075
2290 2290 a, t dbSNP:573308297
2305 2305 -, a dbSNP:35290339
2332 2332 c, t dbSNP:190662034
2359 2359 c, t dbSNP:571776435
2363 2363 c, t dbSNP:17016072
2402 2402 a, t dbSNP:765029456
2529 2529 g, t dbSNP:759307509
2530 2530 c, t dbSNP:776177886
2543 2543 c, t dbSNP:544732987
2579 2579 c, t dbSNP:561717303
2582 2582 c, t dbSNP:186189862
2584 2584 -, gggggg dbSNP:144110885
2669 2669 a, g dbSNP:766004459
2701 2701 c, g dbSNP:760219959
2718 2718 a, g dbSNP:538140807
2723 2723 c, t dbSNP:553070344
2791 2791 a, g dbSNP:3857053
2792 2792 a, g dbSNP:555697933
2794 2794 a, t dbSNP:1045722
2833 2833 g, t dbSNP:774934945
2849 2849 a, c dbSNP:557129591
2889 2889 a, g dbSNP:566899780
2913 2913 a, c dbSNP:551886776
2916 2916 a, g dbSNP:183802441
2963 2963 a, c dbSNP:375815714
2977 2977 c, t dbSNP:550895688
2998 2998 c, t dbSNP:769608000
3006 3006 a, t dbSNP:529553259
3017 3017 a, g dbSNP:371499244
3047 3047 c, t dbSNP:749619202
3058 3058 -, g dbSNP:34094043
3059 3059 g, t dbSNP:143616400
3064 3064 a, c dbSNP:745455499
3119 3119 a, g dbSNP:528466368
3208 3208 a, t dbSNP:548938652

Target ORF information:

RefSeq Version NM_000345
Organism Homo sapiens (human)
Definition Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000345

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24073
Accession Version NM_007308.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 339bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform NACP112
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093759.3, D31839.1 and AC097478.2. On Mar 26, 2009 this sequence version replaced gi:6806897. Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (4, also known as NACP112) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (NACP112) has the same N- and C-termini but is shorter compared to isoform NACP140. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG714648.1, BI667295.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGGAAG GGTATCAAGA CTACGAACCT GAAGCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_009292.1
CDS260..598
Misc Feature(1)242..244(+)
Misc Feature(2)260..>568(+)
Misc Feature(3)518..520(+)
Misc Feature(4)581..583(+)
Exon (1)1..234
Gene:SNCA
Gene Synonym:
Exon (2)235..380
Gene:SNCA
Gene Synonym:
Exon (3)381..422
Gene:SNCA
Gene Synonym:
Exon (4)423..565
Gene:SNCA
Gene Synonym:
Exon (5)566..3127
Gene:SNCA
Gene Synonym:
Translation
Position Chain Variation Link
7 7 a, c dbSNP:182006507
14 14 a, c dbSNP:530541543
15 15 a, g dbSNP:569601627
22 22 a, g dbSNP:548276692
30 30 c, t dbSNP:545809130
56 56 c, g dbSNP:35064456
78 78 a, g dbSNP:540893098
147 147 a, g dbSNP:376844427
170 170 a, t dbSNP:532257366
179 179 a, t dbSNP:564849543
180 180 -, t dbSNP:201360644
180 180 aa, tt dbSNP:71594901
180 180 a, t dbSNP:2245804
181 181 -, t dbSNP:200200161
181 181 a, t dbSNP:2583986
182 182 a, t dbSNP:554728728
186 186 -, a dbSNP:3833895
226 226 c, g dbSNP:543101751
228 228 g, t dbSNP:530627289
237 237 c, t dbSNP:769265023
251 251 -, aatt dbSNP:769191615
253 253 a, g dbSNP:745412490
255 255 c, t dbSNP:780787014
266 266 a, g dbSNP:770296707
268 268 a, g dbSNP:370989462
271 271 a, c dbSNP:777339905
286 286 a, g dbSNP:758254766
298 298 a, c, g dbSNP:774124882
312 312 c, g dbSNP:752472160
318 318 a, g dbSNP:778867145
325 325 a, c dbSNP:754909792
335 335 a, g dbSNP:753674628
347 347 c, g dbSNP:104893878
358 358 a, g dbSNP:766497794
364 364 a, g dbSNP:768334864
368 368 a, g dbSNP:750745088
376 376 g, t dbSNP:372201440
379 379 a, g dbSNP:767842851
381 381 a, g dbSNP:750512067
395 395 a, g dbSNP:104893875
406 406 a, g dbSNP:141859659
409 409 g, t dbSNP:201106962
411 411 a, g dbSNP:431905511
415 415 g, t dbSNP:148108612
416 416 a, g dbSNP:104893877
417 417 c, g, t dbSNP:542171324
419 419 a, g dbSNP:374953392
425 425 a, g dbSNP:751833438
436 436 c, t dbSNP:764216470
448 448 a, g dbSNP:371864975
462 462 a, g dbSNP:752981956
466 466 a, g dbSNP:765809605
469 469 a, g dbSNP:529511227
471 471 c, t dbSNP:777070190
474 474 c, t dbSNP:767026129
475 475 a, g dbSNP:144758871
476 476 g, t dbSNP:774113587
484 484 a, t dbSNP:149401968
502 502 a, g dbSNP:568436589
505 505 a, g dbSNP:775179895
510 510 g, t dbSNP:386352363
530 530 a, g dbSNP:769664191
531 531 a, c dbSNP:745815563
546 546 a, g dbSNP:548523899
555 555 a, g dbSNP:757477802
557 557 c, t dbSNP:138969470
569 569 a, g dbSNP:749526106
573 573 a, g dbSNP:377006107
583 583 c, t dbSNP:76642636
587 587 c, t dbSNP:375682339
588 588 a, c dbSNP:746232417
594 594 c, t dbSNP:781595227
595 595 c, g dbSNP:757748949
617 617 c, g dbSNP:747474608
621 621 a, c dbSNP:778588756
636 636 a, c dbSNP:754479691
638 638 a, g dbSNP:753544938
641 641 -, g dbSNP:755608841
642 642 c, t dbSNP:779277002
648 648 a, c dbSNP:755913681
654 654 c, g dbSNP:778443752
675 675 a, c dbSNP:145304567
679 679 g, t dbSNP:373801428
681 681 c, t dbSNP:370319708
709 709 a, t dbSNP:772716317
710 710 a, g dbSNP:748631342
714 714 c, g, t dbSNP:144511886
715 715 a, g dbSNP:184023281
716 716 a, g dbSNP:560702695
737 737 g, t dbSNP:10024743
760 760 c, t dbSNP:578250733
770 770 c, t dbSNP:192194319
771 771 a, g dbSNP:79726680
772 772 c, g dbSNP:187958987
792 792 c, t dbSNP:34825021
800 800 c, t dbSNP:185476145
801 801 a, g dbSNP:35716318
806 806 c, t dbSNP:565855781
847 847 a, g dbSNP:553599518
871 871 c, t dbSNP:193289281
880 880 a, t dbSNP:571218440
911 911 g, t dbSNP:549732620
921 921 c, t dbSNP:755315517
974 974 c, t dbSNP:35733299
1021 1021 a, g dbSNP:567582133
1048 1048 a, c dbSNP:754013370
1062 1062 a, c dbSNP:183204610
1065 1065 c, g dbSNP:533910909
1068 1068 g, t dbSNP:780286202
1084 1084 a, t dbSNP:370791472
1099 1099 c, t dbSNP:17016074
1100 1100 a, g dbSNP:560621582
1178 1178 -, atttt dbSNP:756360541
1184 1184 a, g dbSNP:545627654
1191 1191 a, c dbSNP:35101723
1248 1248 a, t dbSNP:563195772
1252 1252 c, t dbSNP:544604827
1283 1283 a, g dbSNP:575975134
1351 1351 a, c dbSNP:750566704
1356 1356 c, t dbSNP:554306228
1374 1374 g, t dbSNP:373978617
1396 1396 c, g dbSNP:571813266
1420 1420 a, g dbSNP:35343095
1448 1448 a, g dbSNP:553513542
1450 1450 g, t dbSNP:150645039
1458 1458 a, t dbSNP:577490090
1491 1491 cgt, tgc dbSNP:386677144
1491 1491 c, t dbSNP:356165
1492 1492 a, g dbSNP:192179063
1493 1493 c, t dbSNP:187002185
1519 1519 a, g dbSNP:148246747
1588 1588 a, g dbSNP:532997483
1600 1600 g, t dbSNP:182722435
1614 1614 c, t dbSNP:566987021
1631 1631 c, t dbSNP:550521282
1645 1645 g, t dbSNP:532025477
1690 1690 -, a dbSNP:750347645
1690 1690 -, a dbSNP:571454522
1692 1692 -, t dbSNP:143570143
1700 1700 c, t dbSNP:561544802
1769 1769 c, t dbSNP:551974660
1807 1807 a, g dbSNP:533541220
1822 1822 a, g dbSNP:147204331
1845 1845 a, t dbSNP:77964369
1857 1857 -, tc dbSNP:5860180
1871 1871 -, tctc dbSNP:761782877
1871 1871 -, tc dbSNP:765487318
1872 1872 -, ctct dbSNP:141457381
1872 1872 -, ct dbSNP:533408267
1874 1874 -, ct dbSNP:35270750
1874 1874 c, t dbSNP:201351609
1878 1878 c, t dbSNP:200268319
1885 1885 a, g dbSNP:377356638
1887 1887 c, t dbSNP:527798413
1890 1890 c, t dbSNP:1987877
1890 1890 -, ttttt dbSNP:397994464
1907 1907 -, tttt, ttttt, tttttt dbSNP:777296100
2004 2004 a, g dbSNP:529496201
2026 2026 a, g dbSNP:767553862
2075 2075 c, t dbSNP:560896156
2081 2081 a, t dbSNP:758398107
2088 2088 c, t dbSNP:752617075
2202 2202 a, t dbSNP:573308297
2217 2217 -, a dbSNP:35290339
2244 2244 c, t dbSNP:190662034
2271 2271 c, t dbSNP:571776435
2275 2275 c, t dbSNP:17016072
2314 2314 a, t dbSNP:765029456
2441 2441 g, t dbSNP:759307509
2442 2442 c, t dbSNP:776177886
2455 2455 c, t dbSNP:544732987
2491 2491 c, t dbSNP:561717303
2494 2494 c, t dbSNP:186189862
2496 2496 -, gggggg dbSNP:144110885
2581 2581 a, g dbSNP:766004459
2613 2613 c, g dbSNP:760219959
2630 2630 a, g dbSNP:538140807
2635 2635 c, t dbSNP:553070344
2703 2703 a, g dbSNP:3857053
2704 2704 a, g dbSNP:555697933
2706 2706 a, t dbSNP:1045722
2745 2745 g, t dbSNP:774934945
2761 2761 a, c dbSNP:557129591
2801 2801 a, g dbSNP:566899780
2825 2825 a, c dbSNP:551886776
2828 2828 a, g dbSNP:183802441
2875 2875 a, c dbSNP:375815714
2889 2889 c, t dbSNP:550895688
2910 2910 c, t dbSNP:769608000
2918 2918 a, t dbSNP:529553259
2929 2929 a, g dbSNP:371499244
2959 2959 c, t dbSNP:749619202
2970 2970 -, g dbSNP:34094043
2971 2971 g, t dbSNP:143616400
2976 2976 a, c dbSNP:745455499
3031 3031 a, g dbSNP:528466368
3120 3120 a, t dbSNP:548938652

Target ORF information:

RefSeq Version NM_007308
Organism Homo sapiens (human)
Definition Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_007308

ORF Insert Sequence:

1
61
121
181
241
301
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGGAAG GGTATCAAGA CTACGAACCT GAAGCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23545
Accession Version NM_001146054.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform NACP140
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093759.3, BC013293.2 and AC097478.2. Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013293.2, BQ231431.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001139526.1
CDS260..682
Misc Feature(1)242..244(+)
Misc Feature(2)260..655(+)
Misc Feature(3)260..262(+)
Misc Feature(4)317..460(+)
Misc Feature(5)518..520(+)
Misc Feature(6)632..634(+)
Misc Feature(7)644..646(+)
Exon (1)1..234
Gene:SNCA
Gene Synonym:
Exon (2)235..380
Gene:SNCA
Gene Synonym:
Exon (3)381..422
Gene:SNCA
Gene Synonym:
Exon (4)423..565
Gene:SNCA
Gene Synonym:
Exon (5)566..649
Gene:SNCA
Gene Synonym:
Exon (6)650..3211
Gene:SNCA
Gene Synonym:
Translation
Position Chain Variation Link
7 7 a, c dbSNP:182006507
14 14 a, c dbSNP:530541543
15 15 a, g dbSNP:569601627
22 22 a, g dbSNP:548276692
30 30 c, t dbSNP:545809130
56 56 c, g dbSNP:35064456
78 78 a, g dbSNP:540893098
147 147 a, g dbSNP:376844427
170 170 a, t dbSNP:532257366
179 179 a, t dbSNP:564849543
180 180 -, t dbSNP:201360644
180 180 aa, tt dbSNP:71594901
180 180 a, t dbSNP:2245804
181 181 -, t dbSNP:200200161
181 181 a, t dbSNP:2583986
182 182 a, t dbSNP:554728728
186 186 -, a dbSNP:3833895
226 226 c, g dbSNP:543101751
228 228 g, t dbSNP:530627289
237 237 c, t dbSNP:769265023
251 251 -, aatt dbSNP:769191615
253 253 a, g dbSNP:745412490
255 255 c, t dbSNP:780787014
266 266 a, g dbSNP:770296707
268 268 a, g dbSNP:370989462
271 271 a, c dbSNP:777339905
286 286 a, g dbSNP:758254766
298 298 a, c, g dbSNP:774124882
312 312 c, g dbSNP:752472160
318 318 a, g dbSNP:778867145
325 325 a, c dbSNP:754909792
335 335 a, g dbSNP:753674628
347 347 c, g dbSNP:104893878
358 358 a, g dbSNP:766497794
364 364 a, g dbSNP:768334864
368 368 a, g dbSNP:750745088
376 376 g, t dbSNP:372201440
379 379 a, g dbSNP:767842851
381 381 a, g dbSNP:750512067
395 395 a, g dbSNP:104893875
406 406 a, g dbSNP:141859659
409 409 g, t dbSNP:201106962
411 411 a, g dbSNP:431905511
415 415 g, t dbSNP:148108612
416 416 a, g dbSNP:104893877
417 417 c, g, t dbSNP:542171324
419 419 a, g dbSNP:374953392
425 425 a, g dbSNP:751833438
436 436 c, t dbSNP:764216470
448 448 a, g dbSNP:371864975
462 462 a, g dbSNP:752981956
466 466 a, g dbSNP:765809605
469 469 a, g dbSNP:529511227
471 471 c, t dbSNP:777070190
474 474 c, t dbSNP:767026129
475 475 a, g dbSNP:144758871
476 476 g, t dbSNP:774113587
484 484 a, t dbSNP:149401968
502 502 a, g dbSNP:568436589
505 505 a, g dbSNP:775179895
510 510 g, t dbSNP:386352363
530 530 a, g dbSNP:769664191
531 531 a, c dbSNP:745815563
546 546 a, g dbSNP:548523899
555 555 a, g dbSNP:757477802
557 557 c, t dbSNP:138969470
568 568 c, t dbSNP:759452333
573 573 a, c dbSNP:776535649
601 601 a, c dbSNP:770804878
605 605 a, g dbSNP:372101729
606 606 c, t dbSNP:760548842
608 608 a, c, t dbSNP:145138372
610 610 a, c, t dbSNP:143084604
617 617 a, c dbSNP:779158137
621 621 a, g dbSNP:768838511
624 624 a, g dbSNP:749476922
625 625 c, t dbSNP:780419569
626 626 a, g dbSNP:200056149
634 634 c, t dbSNP:367556974
640 640 a, g dbSNP:191055637
641 641 a, c dbSNP:750899874
653 653 a, g dbSNP:749526106
657 657 a, g dbSNP:377006107
667 667 c, t dbSNP:76642636
671 671 c, t dbSNP:375682339
672 672 a, c dbSNP:746232417
678 678 c, t dbSNP:781595227
679 679 c, g dbSNP:757748949
701 701 c, g dbSNP:747474608
705 705 a, c dbSNP:778588756
720 720 a, c dbSNP:754479691
722 722 a, g dbSNP:753544938
725 725 -, g dbSNP:755608841
726 726 c, t dbSNP:779277002
732 732 a, c dbSNP:755913681
738 738 c, g dbSNP:778443752
759 759 a, c dbSNP:145304567
763 763 g, t dbSNP:373801428
765 765 c, t dbSNP:370319708
793 793 a, t dbSNP:772716317
794 794 a, g dbSNP:748631342
798 798 c, g, t dbSNP:144511886
799 799 a, g dbSNP:184023281
800 800 a, g dbSNP:560702695
821 821 g, t dbSNP:10024743
844 844 c, t dbSNP:578250733
854 854 c, t dbSNP:192194319
855 855 a, g dbSNP:79726680
856 856 c, g dbSNP:187958987
876 876 c, t dbSNP:34825021
884 884 c, t dbSNP:185476145
885 885 a, g dbSNP:35716318
890 890 c, t dbSNP:565855781
931 931 a, g dbSNP:553599518
955 955 c, t dbSNP:193289281
964 964 a, t dbSNP:571218440
995 995 g, t dbSNP:549732620
1005 1005 c, t dbSNP:755315517
1058 1058 c, t dbSNP:35733299
1105 1105 a, g dbSNP:567582133
1132 1132 a, c dbSNP:754013370
1146 1146 a, c dbSNP:183204610
1149 1149 c, g dbSNP:533910909
1152 1152 g, t dbSNP:780286202
1168 1168 a, t dbSNP:370791472
1183 1183 c, t dbSNP:17016074
1184 1184 a, g dbSNP:560621582
1262 1262 -, atttt dbSNP:756360541
1268 1268 a, g dbSNP:545627654
1275 1275 a, c dbSNP:35101723
1332 1332 a, t dbSNP:563195772
1336 1336 c, t dbSNP:544604827
1367 1367 a, g dbSNP:575975134
1435 1435 a, c dbSNP:750566704
1440 1440 c, t dbSNP:554306228
1458 1458 g, t dbSNP:373978617
1480 1480 c, g dbSNP:571813266
1504 1504 a, g dbSNP:35343095
1532 1532 a, g dbSNP:553513542
1534 1534 g, t dbSNP:150645039
1542 1542 a, t dbSNP:577490090
1575 1575 cgt, tgc dbSNP:386677144
1575 1575 c, t dbSNP:356165
1576 1576 a, g dbSNP:192179063
1577 1577 c, t dbSNP:187002185
1603 1603 a, g dbSNP:148246747
1672 1672 a, g dbSNP:532997483
1684 1684 g, t dbSNP:182722435
1698 1698 c, t dbSNP:566987021
1715 1715 c, t dbSNP:550521282
1729 1729 g, t dbSNP:532025477
1774 1774 -, a dbSNP:750347645
1774 1774 -, a dbSNP:571454522
1776 1776 -, t dbSNP:143570143
1784 1784 c, t dbSNP:561544802
1853 1853 c, t dbSNP:551974660
1891 1891 a, g dbSNP:533541220
1906 1906 a, g dbSNP:147204331
1929 1929 a, t dbSNP:77964369
1941 1941 -, tc dbSNP:5860180
1955 1955 -, tctc dbSNP:761782877
1955 1955 -, tc dbSNP:765487318
1956 1956 -, ctct dbSNP:141457381
1956 1956 -, ct dbSNP:533408267
1958 1958 -, ct dbSNP:35270750
1958 1958 c, t dbSNP:201351609
1962 1962 c, t dbSNP:200268319
1969 1969 a, g dbSNP:377356638
1971 1971 c, t dbSNP:527798413
1974 1974 c, t dbSNP:1987877
1974 1974 -, ttttt dbSNP:397994464
1991 1991 -, tttt, ttttt, tttttt dbSNP:777296100
2088 2088 a, g dbSNP:529496201
2110 2110 a, g dbSNP:767553862
2159 2159 c, t dbSNP:560896156
2165 2165 a, t dbSNP:758398107
2172 2172 c, t dbSNP:752617075
2286 2286 a, t dbSNP:573308297
2301 2301 -, a dbSNP:35290339
2328 2328 c, t dbSNP:190662034
2355 2355 c, t dbSNP:571776435
2359 2359 c, t dbSNP:17016072
2398 2398 a, t dbSNP:765029456
2525 2525 g, t dbSNP:759307509
2526 2526 c, t dbSNP:776177886
2539 2539 c, t dbSNP:544732987
2575 2575 c, t dbSNP:561717303
2578 2578 c, t dbSNP:186189862
2580 2580 -, gggggg dbSNP:144110885
2665 2665 a, g dbSNP:766004459
2697 2697 c, g dbSNP:760219959
2714 2714 a, g dbSNP:538140807
2719 2719 c, t dbSNP:553070344
2787 2787 a, g dbSNP:3857053
2788 2788 a, g dbSNP:555697933
2790 2790 a, t dbSNP:1045722
2829 2829 g, t dbSNP:774934945
2845 2845 a, c dbSNP:557129591
2885 2885 a, g dbSNP:566899780
2909 2909 a, c dbSNP:551886776
2912 2912 a, g dbSNP:183802441
2959 2959 a, c dbSNP:375815714
2973 2973 c, t dbSNP:550895688
2994 2994 c, t dbSNP:769608000
3002 3002 a, t dbSNP:529553259
3013 3013 a, g dbSNP:371499244
3043 3043 c, t dbSNP:749619202
3054 3054 -, g dbSNP:34094043
3055 3055 g, t dbSNP:143616400
3060 3060 a, c dbSNP:745455499
3115 3115 a, g dbSNP:528466368
3204 3204 a, t dbSNP:548938652

Target ORF information:

RefSeq Version NM_001146054
Organism Homo sapiens (human)
Definition Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001146054

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23545
Accession Version NM_001146055.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 423bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-synuclein isoform NACP140
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA391115.1 and AC097478.2. Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA391115.1, BX423130.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001139527.1
CDS71..493
Misc Feature(1)53..55(+)
Misc Feature(2)71..466(+)
Misc Feature(3)71..73(+)
Misc Feature(4)128..271(+)
Misc Feature(5)329..331(+)
Misc Feature(6)443..445(+)
Misc Feature(7)455..457(+)
Exon (1)1..45
Gene:SNCA
Gene Synonym:
Exon (2)46..191
Gene:SNCA
Gene Synonym:
Exon (3)192..233
Gene:SNCA
Gene Synonym:
Exon (4)234..376
Gene:SNCA
Gene Synonym:
Exon (5)377..460
Gene:SNCA
Gene Synonym:
Exon (6)461..3022
Gene:SNCA
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:74786912
31 31 c, t dbSNP:190233303
48 48 c, t dbSNP:769265023
62 62 -, aatt dbSNP:769191615
64 64 a, g dbSNP:745412490
66 66 c, t dbSNP:780787014
77 77 a, g dbSNP:770296707
79 79 a, g dbSNP:370989462
82 82 a, c dbSNP:777339905
97 97 a, g dbSNP:758254766
109 109 a, c, g dbSNP:774124882
123 123 c, g dbSNP:752472160
129 129 a, g dbSNP:778867145
136 136 a, c dbSNP:754909792
146 146 a, g dbSNP:753674628
158 158 c, g dbSNP:104893878
169 169 a, g dbSNP:766497794
175 175 a, g dbSNP:768334864
179 179 a, g dbSNP:750745088
187 187 g, t dbSNP:372201440
190 190 a, g dbSNP:767842851
192 192 a, g dbSNP:750512067
206 206 a, g dbSNP:104893875
217 217 a, g dbSNP:141859659
220 220 g, t dbSNP:201106962
222 222 a, g dbSNP:431905511
226 226 g, t dbSNP:148108612
227 227 a, g dbSNP:104893877
228 228 c, g, t dbSNP:542171324
230 230 a, g dbSNP:374953392
236 236 a, g dbSNP:751833438
247 247 c, t dbSNP:764216470
259 259 a, g dbSNP:371864975
273 273 a, g dbSNP:752981956
277 277 a, g dbSNP:765809605
280 280 a, g dbSNP:529511227
282 282 c, t dbSNP:777070190
285 285 c, t dbSNP:767026129
286 286 a, g dbSNP:144758871
287 287 g, t dbSNP:774113587
295 295 a, t dbSNP:149401968
313 313 a, g dbSNP:568436589
316 316 a, g dbSNP:775179895
321 321 g, t dbSNP:386352363
341 341 a, g dbSNP:769664191
342 342 a, c dbSNP:745815563
357 357 a, g dbSNP:548523899
366 366 a, g dbSNP:757477802
368 368 c, t dbSNP:138969470
379 379 c, t dbSNP:759452333
384 384 a, c dbSNP:776535649
412 412 a, c dbSNP:770804878
416 416 a, g dbSNP:372101729
417 417 c, t dbSNP:760548842
419 419 a, c, t dbSNP:145138372
421 421 a, c, t dbSNP:143084604
428 428 a, c dbSNP:779158137
432 432 a, g dbSNP:768838511
435 435 a, g dbSNP:749476922
436 436 c, t dbSNP:780419569
437 437 a, g dbSNP:200056149
445 445 c, t dbSNP:367556974
451 451 a, g dbSNP:191055637
452 452 a, c dbSNP:750899874
464 464 a, g dbSNP:749526106
468 468 a, g dbSNP:377006107
478 478 c, t dbSNP:76642636
482 482 c, t dbSNP:375682339
483 483 a, c dbSNP:746232417
489 489 c, t dbSNP:781595227
490 490 c, g dbSNP:757748949
512 512 c, g dbSNP:747474608
516 516 a, c dbSNP:778588756
531 531 a, c dbSNP:754479691
533 533 a, g dbSNP:753544938
536 536 -, g dbSNP:755608841
537 537 c, t dbSNP:779277002
543 543 a, c dbSNP:755913681
549 549 c, g dbSNP:778443752
570 570 a, c dbSNP:145304567
574 574 g, t dbSNP:373801428
576 576 c, t dbSNP:370319708
604 604 a, t dbSNP:772716317
605 605 a, g dbSNP:748631342
609 609 c, g, t dbSNP:144511886
610 610 a, g dbSNP:184023281
611 611 a, g dbSNP:560702695
632 632 g, t dbSNP:10024743
655 655 c, t dbSNP:578250733
665 665 c, t dbSNP:192194319
666 666 a, g dbSNP:79726680
667 667 c, g dbSNP:187958987
687 687 c, t dbSNP:34825021
695 695 c, t dbSNP:185476145
696 696 a, g dbSNP:35716318
701 701 c, t dbSNP:565855781
742 742 a, g dbSNP:553599518
766 766 c, t dbSNP:193289281
775 775 a, t dbSNP:571218440
806 806 g, t dbSNP:549732620
816 816 c, t dbSNP:755315517
869 869 c, t dbSNP:35733299
916 916 a, g dbSNP:567582133
943 943 a, c dbSNP:754013370
957 957 a, c dbSNP:183204610
960 960 c, g dbSNP:533910909
963 963 g, t dbSNP:780286202
979 979 a, t dbSNP:370791472
994 994 c, t dbSNP:17016074
995 995 a, g dbSNP:560621582
1073 1073 -, atttt dbSNP:756360541
1079 1079 a, g dbSNP:545627654
1086 1086 a, c dbSNP:35101723
1143 1143 a, t dbSNP:563195772
1147 1147 c, t dbSNP:544604827
1178 1178 a, g dbSNP:575975134
1246 1246 a, c dbSNP:750566704
1251 1251 c, t dbSNP:554306228
1269 1269 g, t dbSNP:373978617
1291 1291 c, g dbSNP:571813266
1315 1315 a, g dbSNP:35343095
1343 1343 a, g dbSNP:553513542
1345 1345 g, t dbSNP:150645039
1353 1353 a, t dbSNP:577490090
1386 1386 cgt, tgc dbSNP:386677144
1386 1386 c, t dbSNP:356165
1387 1387 a, g dbSNP:192179063
1388 1388 c, t dbSNP:187002185
1414 1414 a, g dbSNP:148246747
1483 1483 a, g dbSNP:532997483
1495 1495 g, t dbSNP:182722435
1509 1509 c, t dbSNP:566987021
1526 1526 c, t dbSNP:550521282
1540 1540 g, t dbSNP:532025477
1585 1585 -, a dbSNP:750347645
1585 1585 -, a dbSNP:571454522
1587 1587 -, t dbSNP:143570143
1595 1595 c, t dbSNP:561544802
1664 1664 c, t dbSNP:551974660
1702 1702 a, g dbSNP:533541220
1717 1717 a, g dbSNP:147204331
1740 1740 a, t dbSNP:77964369
1752 1752 -, tc dbSNP:5860180
1766 1766 -, tctc dbSNP:761782877
1766 1766 -, tc dbSNP:765487318
1767 1767 -, ctct dbSNP:141457381
1767 1767 -, ct dbSNP:533408267
1769 1769 -, ct dbSNP:35270750
1769 1769 c, t dbSNP:201351609
1773 1773 c, t dbSNP:200268319
1780 1780 a, g dbSNP:377356638
1782 1782 c, t dbSNP:527798413
1785 1785 c, t dbSNP:1987877
1785 1785 -, ttttt dbSNP:397994464
1802 1802 -, tttt, ttttt, tttttt dbSNP:777296100
1899 1899 a, g dbSNP:529496201
1921 1921 a, g dbSNP:767553862
1970 1970 c, t dbSNP:560896156
1976 1976 a, t dbSNP:758398107
1983 1983 c, t dbSNP:752617075
2097 2097 a, t dbSNP:573308297
2112 2112 -, a dbSNP:35290339
2139 2139 c, t dbSNP:190662034
2166 2166 c, t dbSNP:571776435
2170 2170 c, t dbSNP:17016072
2209 2209 a, t dbSNP:765029456
2336 2336 g, t dbSNP:759307509
2337 2337 c, t dbSNP:776177886
2350 2350 c, t dbSNP:544732987
2386 2386 c, t dbSNP:561717303
2389 2389 c, t dbSNP:186189862
2391 2391 -, gggggg dbSNP:144110885
2476 2476 a, g dbSNP:766004459
2508 2508 c, g dbSNP:760219959
2525 2525 a, g dbSNP:538140807
2530 2530 c, t dbSNP:553070344
2598 2598 a, g dbSNP:3857053
2599 2599 a, g dbSNP:555697933
2601 2601 a, t dbSNP:1045722
2640 2640 g, t dbSNP:774934945
2656 2656 a, c dbSNP:557129591
2696 2696 a, g dbSNP:566899780
2720 2720 a, c dbSNP:551886776
2723 2723 a, g dbSNP:183802441
2770 2770 a, c dbSNP:375815714
2784 2784 c, t dbSNP:550895688
2805 2805 c, t dbSNP:769608000
2813 2813 a, t dbSNP:529553259
2824 2824 a, g dbSNP:371499244
2854 2854 c, t dbSNP:749619202
2865 2865 -, g dbSNP:34094043
2866 2866 g, t dbSNP:143616400
2871 2871 a, c dbSNP:745455499
2926 2926 a, g dbSNP:528466368
3015 3015 a, t dbSNP:548938652

Target ORF information:

RefSeq Version NM_001146055
Organism Homo sapiens (human)
Definition Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001146055

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGATGTAT TCATGAAAGG ACTTTCAAAG GCCAAGGAGG GAGTTGTGGC TGCTGCTGAG 
AAAACCAAAC AGGGTGTGGC AGAAGCAGCA GGAAAGACAA AAGAGGGTGT TCTCTATGTA
GGCTCCAAAA CCAAGGAGGG AGTGGTGCAT GGTGTGGCAA CAGTGGCTGA GAAGACCAAA
GAGCAAGTGA CAAATGTTGG AGGAGCAGTG GTGACGGGTG TGACAGCAGT AGCCCAGAAG
ACAGTGGAGG GAGCAGGGAG CATTGCAGCA GCCACTGGCT TTGTCAAAAA GGACCAGTTG
GGCAAGAATG AAGAAGGAGC CCCACAGGAA GGAATTCTGG AAGATATGCC TGTGGATCCT
GACAATGAGG CTTATGAAAT GCCTTCTGAG GAAGGGTATC AAGACTACGA ACCTGAAGCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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