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FOXL2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol FOXL2
Entrez Gene ID 668
Full Name forkhead box L2
Synonyms BPES, BPES1, PFRK, PINTO, POF3
General protein information
Preferred Names
forkhead box protein L2
Names
forkhead box protein L2
forkhead transcription factor FOXL2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q23

Summary This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jun 2009]. lac of sum
Disorder MIM:

605597

Disorder Html: Blepharophimosis, epicanthus inversus, and ptosis, type 1, 110100

mRNA and Protein(s)

mRNA Protein Name
NM_023067 NP_075555 forkhead box protein L2


Homo sapiens (human) FOXL2 NP_075555.1
Pan troglodytes (chimpanzee) FOXL2 XP_526323.2
Macaca mulatta (Rhesus monkey) LOC717906 XP_001109917.2
Bos taurus (cattle) FOXL2 NP_001026920.1
Mus musculus (house mouse) Foxl2 NP_036150.1
Rattus norvegicus (Norway rat) Foxl2 XP_003750619.1
Danio rerio (zebrafish) LOC100149117 XP_001922861.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOXL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20709
NM_023067 Homo sapiens forkhead box L2 (FOXL2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20709
Clone ID Related Accession (Same CDS sequence) NM_023067
Accession Version NM_023067.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1131bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-MAY-2014
Organism Homo sapiens (human)
Product forkhead box protein L2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092947.12. This sequence is a reference standard in the RefSeqGene project. On Jun 10, 2009 this sequence version replaced gi:42716284. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_075555.1
CDS419..1549
Misc Feature(1)317..319(+)
Misc Feature(2)578..811(+)
Misc Feature(3)686..790(+)
Misc Feature(4)1205..1207(+)
Exon (1)1..2917
Gene:FOXL2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_023067
Organism Homo sapiens (human)
Definition Homo sapiens forkhead box L2 (FOXL2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_023067

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGATGGCCA GCTACCCCGA GCCCGAGGAC GCGGCGGGGG CCCTGCTGGC CCCAGAGACC 
GGTCGCACAG TCAAGGAGCC AGAAGGGCCG CCGCCGAGCC CAGGCAAGGG CGGTGGGGGT
GGCGGCGGGA CAGCCCCGGA GAAGCCGGAC CCGGCGCAGA AGCCCCCGTA CTCGTACGTG
GCGCTCATCG CCATGGCGAT CCGCGAGAGC GCGGAGAAGA GGCTCACGCT GTCCGGCATC
TACCAGTACA TCATCGCGAA GTTCCCGTTC TACGAGAAGA ATAAGAAGGG CTGGCAAAAT
AGCATCCGCC ACAACCTCAG CCTCAACGAG TGCTTCATCA AGGTGCCGCG CGAGGGCGGC
GGCGAGCGCA AGGGCAACTA CTGGACGCTG GACCCGGCCT GCGAAGACAT GTTCGAGAAG
GGCAACTACC GGCGCCGCCG CCGCATGAAG AGGCCCTTCC GGCCGCCGCC CGCGCACTTC
CAGCCCGGCA AGGGGCTCTT CGGGGCCGGA GGCGCCGCAG GCGGGTGCGG CGTGGCGGGC
GCCGGGGCCG ACGGCTACGG CTACCTGGCG CCCCCCAAGT ACCTGCAGTC TGGCTTCCTC
AACAACTCGT GGCCGCTACC GCAGCCTCCC TCACCCATGC CCTATGCCTC CTGCCAGATG
GCGGCAGCCG CAGCGGCTGC AGCAGCTGCG GCTGCAGCCG CGGGCCCCGG TAGCCCTGGC
GCGGCCGCTG TGGTCAAGGG GCTGGCGGGC CCGGCCGCCT CGTACGGGCC GTACACACGC
GTGCAGAGCA TGGCGCTGCC CCCCGGCGTA GTGAACTCGT ACAATGGCCT GGGAGGCCCG
CCGGCCGCAC CCCCGCCTCC GCCGCACCCC CACCCGCATC CGCACGCACA CCATCTGCAC
GCGGCCGCCG CACCGCCGCC TGCCCCACCG CACCACGGGG CCGCCGCGCC GCCGCCGGGC
CAGCTCAGCC CTGCCAGCCC AGCCACCGCC GCGCCCCCGG CGCCCGCGCC CACCAGTGCG
CCGGGCCTGC AGTTCGCTTG TGCCCGGCAG CCCGAGCTCG CCATGATGCA TTGCTCTTAC
TGGGACCACG ACAGCAAGAC CGGCGCGCTG CATTCGCGCC TCGATCTCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

FOXL2-induced follistatin attenuates activin A-stimulated cell proliferation in human granulosa cell tumors
Biochem. Biophys. Res. Commun. 443 (2), 537-542 (2014)
Cheng JC, Chang HM, Qiu X, Fang L and Leung PC.


book

Impact of a second opinion using expression and molecular analysis of FOXL2 for sex cord-stromal tumors. A study of the GINECO group & the TMRO network
Gynecol. Oncol. 132 (1), 181-187 (2014)
Maillet D, Goulvent T, Rimokh R, Vacher-Lavenu MC, Pautier P, Alexandre J, Pujade-Laurraine E, Devouassoux-Shisheboran M, Treilleux I, Ray-Coquard I and Savina A.


book

Identification of the forkhead transcriptional factor 2 (FOXL2) gene mutations in four Chinese families with blepharophimosis syndrome
Mol. Vis. 19, 2298-2305 (2013)
Zhang L, Wang L, Han R, Guan L, Fan B, Liu M, Ying M, Peng H and Li N.


book

Adult granulosa cell tumours (GCT): clinicopathological outcomes including FOXL2 mutational status and expression
Gynecol. Oncol. 131 (2), 325-329 (2013)
Rosario R, Wilson M, Cheng WT, Payne K, Cohen PA, Fong P and Shelling AN.


book

Luteinized thecomas (thecomatosis) associated with sclerosing peritonitis exhibit positive staining with sex cord markers steroidogenic factor-1 (SF-1) and FOXL2
Am. J. Surg. Pathol. 37 (9), 1458-1459 (2013)
McCluggage WG, Staats PN, Gilks CB, Clement PB and Young RH.


book

The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
Nat. Genet. 27 (2), 159-166 (2001)
Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A and Pilia G.


book

Unified nomenclature for the winged helix/forkhead transcription factors
Genes Dev. 14 (2), 142-146 (2000)
Kaestner KH, Knochel W and Martinez DE.


book

High-resolution human/goat comparative map of the goat polled/intersex syndrome (PIS): the human homologue is contained in a human YAC from HSA3q23
Genomics 56 (1), 31-39 (1999)
Vaiman D, Schibler L, Oustry-Vaiman A, Pailhoux E, Goldammer T, Stevanovic M, Furet JP, Schwerin M, Cotinot C, Fellous M and Cribiu EP.


book

Blepharophimosis, Ptosis, and Epicanthus Inversus
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
De Baere,E.


book

Further evidence for the location of the BPES gene at 3q2
J. Med. Genet. 28 (10), 725 (1991)
de Die-Smulders,C.E., Engelen,J.J., Donk,J.M. and Fryns,J.P.


 
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