Email to GenScript

SPINK1 serine peptidase inhibitor, Kazal type 1 [Homo sapiens (human)]

Gene Symbol SPINK1
Entrez Gene ID 6690
Full Name serine peptidase inhibitor, Kazal type 1
Synonyms PCTT, PSTI, Spink3, TATI, TCP
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

167790

Disorder Html: Pancreatitis, hereditary, 167800 (3); {Fibrocalculous pancreatic





The following SPINK1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPINK1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu28321 NM_003122 Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu28321
Accession Version NM_003122.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 240bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pancreatic secretory trypsin inhibitor precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB159576.1, BC025790.1 and BU074107.1. This sequence is a reference standard in the RefSeqGene project. On or before Jun 20, 2014 this sequence version replaced gi:530380662, gi:195234783. Summary: The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB159576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
ATGAAGGTAA CAGGCATCTT TCTTCTCAGT GCCTTGGCCC TGTTGAGTCT ATCTGGTAAC 
ACTGGAGCTG ACTCCCTGGG AAGAGAGGCC AAATGTTACA ATGAACTTAA TGGATGCACC
AAGATATATG ACCCTGTCTG TGGGACTGAT GGAAATACTT ATCCCAATGA ATGCGTGTTA
TGTTTTGAAA ATCGGAAACG CCAGACTTCT ATCCTCATTC AAAAATCTGG GCCTTGCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003113.2
CDS290..529
Misc Feature(1)242..244(+)
Misc Feature(2)392..526(+)
Misc Feature(3)410..415(+)
Misc Feature(4)410..415(+)
Misc Feature(5)410..412(+)
Exon (1)1..98
Gene:SPINK1
Gene Synonym:
Exon (2)99..344
Gene:SPINK1
Gene Synonym:
Exon (3)345..376
Gene:SPINK1
Gene Synonym:
Exon (4)377..483
Gene:SPINK1
Gene Synonym:
Exon (5)484..610
Gene:SPINK1
Gene Synonym:
Translation
Position Chain Variation Link
13 13 a, g dbSNP:114188218
36 36 a, c dbSNP:565973425
39 39 a, g dbSNP:553910214
126 126 c, g dbSNP:74352029
143 143 a, g dbSNP:779832256
148 148 c, t dbSNP:755968566
208 208 a, g dbSNP:6865184
237 237 c, t dbSNP:367798627
238 238 a, g dbSNP:376017936
240 240 a, g dbSNP:780913633
244 244 -, a dbSNP:577417642
245 245 a, g dbSNP:746065379
247 247 a, g dbSNP:185818957
248 248 a, c, t dbSNP:181484530
249 249 a, g dbSNP:79438751
250 250 a, g dbSNP:560283989
262 262 a, g dbSNP:753168692
268 268 c, t dbSNP:190219062
270 270 c, t dbSNP:529746687
273 273 a, g dbSNP:369531839
275 275 a, c, t dbSNP:148434824
276 276 a, g dbSNP:373391756
282 282 c, t dbSNP:765154907
288 288 a, c dbSNP:761643947
290 290 a, g dbSNP:369163833
291 291 c, t dbSNP:104893938
294 294 a, g dbSNP:145448373
297 297 c, t dbSNP:768306142
303 303 a, g dbSNP:759869911
316 316 -, c dbSNP:193922659
318 318 a, g dbSNP:543771454
320 320 a, g dbSNP:771152309
322 322 c, t dbSNP:147454311
325 325 c, g dbSNP:35877720
327 327 c, t dbSNP:770387107
330 330 c, g, t dbSNP:104893939
338 338 c, t dbSNP:748579590
343 343 g, t dbSNP:781647751
360 360 a, c dbSNP:766778368
364 364 c, g, t dbSNP:35006579
369 369 a, g dbSNP:769727763
371 371 a, g dbSNP:375368064
377 377 g, t dbSNP:763305086
382 382 -, atgttacaa dbSNP:767903021
390 390 a, g dbSNP:17107315
394 394 a, t dbSNP:765379826
398 398 a, c dbSNP:761739859
399 399 a, g dbSNP:200142833
400 400 c, t dbSNP:769216699
415 415 a, g dbSNP:370266754
423 423 c, t dbSNP:775872440
425 425 c, g dbSNP:772387015
439 439 g, t dbSNP:515726206
447 447 c, t dbSNP:745557876
449 449 c, t dbSNP:515726207
451 451 c, t dbSNP:778375105
452 452 c, g, t dbSNP:111966833
454 454 c, g dbSNP:748820833
459 459 a, c dbSNP:777412858
462 462 a, g dbSNP:756166467
463 463 c, t dbSNP:35737774
464 464 a, g dbSNP:781162491
465 465 a, t dbSNP:754677627
466 466 a, g dbSNP:750670272
481 481 c, t dbSNP:765307896
482 482 c, t dbSNP:536203389
483 483 a, g dbSNP:141634296
487 487 a, c dbSNP:143014431
488 488 c, t dbSNP:515726208
489 489 a, g dbSNP:35523678
490 490 c, g dbSNP:767978919
492 492 a, g dbSNP:760077990
494 494 a, g dbSNP:543704459
495 495 c, t dbSNP:576564400
497 497 a, t dbSNP:373011963
504 504 c, t dbSNP:749558779
505 505 c, t dbSNP:543864495
507 507 c, t dbSNP:200263045
520 520 a, g dbSNP:34809998
526 526 c, g dbSNP:768532836
532 532 a, g dbSNP:1804247
538 538 a, g dbSNP:369604230
540 540 g, t dbSNP:746943373
552 552 a, g, t dbSNP:372615240
555 555 c, g dbSNP:758164084
556 556 g, t dbSNP:368871387
561 561 c, t dbSNP:11319
562 562 a, c, g, t dbSNP:372279808
563 563 c, t dbSNP:377333227
564 564 a, g dbSNP:752062590
567 567 g, t dbSNP:766673251
577 577 c, t dbSNP:763350070
580 580 c, t dbSNP:113527737
595 595 a, g dbSNP:745817577
609 609 a, c, g dbSNP:112657606
610 610 a, c, g dbSNP:113677347

Target ORF information:

RefSeq Version NM_003122
Organism Homo sapiens (human)
Definition Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003122

ORF Insert Sequence:

1
61
121
181
ATGAAGGTAA CAGGCATCTT TCTTCTCAGT GCCTTGGCCC TGTTGAGTCT ATCTGGTAAC 
ACTGGAGCTG ACTCCCTGGG AAGAGAGGCC AAATGTTACA ATGAACTTAA TGGATGCACC
AAGATATATG ACCCTGTCTG TGGGACTGAT GGAAATACTT ATCCCAATGA ATGCGTGTTA
TGTTTTGAAA ATCGGAAACG CCAGACTTCT ATCCTCATTC AAAAATCTGG GCCTTGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.