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SRY cDNA ORF clone, Homo sapiens (human)

Gene Symbol SRY
Entrez Gene ID 6736
Full Name sex determining region Y
Synonyms SRXX1, SRXY1, TDF, TDY
General protein information
Preferred Names
sex-determining region Y protein
Names
sex-determining region Y protein
sex-determining region on Y
testis-determining factor on Y
essential protein for sex determination in human males
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

Y

Yp11.3

Summary This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

480000

Disorder Html: 46XY complete gonadal dysgenesis, 400044 (3); 46XX true





The following SRY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu28314 NM_003140 Homo sapiens sex determining region Y (SRY), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

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**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu28314
Accession Version NM_003140.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 615bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 20-JUN-2014
Organism Homo sapiens (human)
Product sex-determining region Y protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006040.3 and L10101.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced gi:4507224. Summary: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_003131.1
CDS139..753
Misc Feature(1)1..1(+)
Misc Feature(2)79..81(+)
Misc Feature(3)313..546(+)
Misc Feature(4)313..528(+)
Misc Feature(5)319..369(+)
Misc Feature(6)322..489(+)
Misc Feature(7)457..555(+)
Misc Feature(8)526..546(+)
Misc Feature(9)544..546(+)
Misc Feature(10)550..603(+)
Misc Feature(11)730..750(+)
Exon (1)1..887
Gene:SRY
Gene Synonym:
Translation
Position Chain Variation Link
29 29 a, t dbSNP:759981348
130 130 a, t dbSNP:754712640
133 133 c, t dbSNP:754209742
136 136 a, g dbSNP:766867548
142 142 c, t dbSNP:104894977
150 150 a, t dbSNP:104894975
191 191 a, g dbSNP:104894971
201 201 g, t dbSNP:751006997
286 286 a, g dbSNP:767481926
308 308 a, g dbSNP:762003265
312 312 g, t dbSNP:773764555
316 316 c, g dbSNP:104894957
317 317 c, t dbSNP:764249635
330 330 a, g dbSNP:104894969
341 341 c, t dbSNP:104894968
343 343 c, g dbSNP:763174397
347 347 a, g dbSNP:104894965
357 357 g, t dbSNP:776339584
389 389 c, g dbSNP:770778716
392 392 a, t dbSNP:746931713
408 408 c, g dbSNP:104894959
412 412 a, t dbSNP:104894970
415 415 c, t dbSNP:104894958
421 421 c, g dbSNP:104894974
422 422 a, g dbSNP:104894972
455 455 a, t dbSNP:104894964
458 458 a, g dbSNP:104894967
462 462 -, a dbSNP:606231179
464 464 c, t dbSNP:104894956
475 475 a, g dbSNP:104894966
477 477 a, c dbSNP:773247144
502 502 -, gaga dbSNP:606231178
502 502 a, g dbSNP:771449441
518 518 a, t dbSNP:104894973
521 521 a, g dbSNP:375342012
535 535 c, t dbSNP:104894976
603 603 c, t dbSNP:11575897
606 606 a, c dbSNP:754623064
629 629 a, g dbSNP:748958243
698 698 a, g dbSNP:780561417
727 727 c, t dbSNP:756606002
775 775 a, g dbSNP:757482837
780 780 c, g dbSNP:750874990
804 804 c, g dbSNP:781744002

Target ORF information:

RefSeq Version NM_003140
Organism Homo sapiens (human)
Definition Homo sapiens sex determining region Y (SRY), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003140

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCAATCAT ATGCTTCTGC TATGTTAAGC GTATTCAACA GCGATGATTA CAGTCCAGCT 
GTGCAAGAGA ATATTCCCGC TCTCCGGAGA AGCTCTTCCT TCCTTTGCAC TGAAAGCTGT
AACTCTAAGT ATCAGTGTGA AACGGGAGAA AACAGTAAAG GCAACGTCCA GGATAGAGTG
AAGCGACCCA TGAACGCATT CATCGTGTGG TCTCGCGATC AGAGGCGCAA GATGGCTCTA
GAGAATCCCA GAATGCGAAA CTCAGAGATC AGCAAGCAGC TGGGATACCA GTGGAAAATG
CTTACTGAAG CCGAAAAATG GCCATTCTTC CAGGAGGCAC AGAAATTACA GGCCATGCAC
AGAGAGAAAT ACCCGAATTA TAAGTATCGA CCTCGTCGGA AGGCGAAGAT GCTGCCGAAG
AATTGCAGTT TGCTTCCCGC AGATCCCGCT TCGGTACTCT GCAGCGAAGT GCAACTGGAC
AACAGGTTGT ACAGGGATGA CTGTACGAAA GCCACACACT CAAGAATGGA GCACCAGCTA
GGCCACTTAC CGCCCATCAA CGCAGCCAGC TCACCGCAGC AACGGGACCG CTACAGCCAC
TGGACAAAGC TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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