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BST2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol BST2
Entrez Gene ID 684
Full Name bone marrow stromal cell antigen 2
Synonyms CD317, TETHERIN
General protein information
Preferred Names
bone marrow stromal antigen 2
Names
bone marrow stromal antigen 2
BST-2
NPC-A-7
HM1.24 antigen
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600534

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_004335 NP_004326 bone marrow stromal antigen 2 precursor

Reactome
R-HSA-168256 Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-913531 Interferon Signaling


Homo sapiens (human) BST2 NP_004326.1
Pan troglodytes (chimpanzee) BST2 NP_001177409.1
Macaca mulatta (Rhesus monkey) BST2 NP_001155138.1
Canis lupus familiaris (dog) BST2 XP_865603.1

Component

ID Name Evidence
GO:0005770 late endosome IEA
GO:0005794 Golgi apparatus IEA
GO:0005887 integral to plasma membrane TAS
GO:0031225 anchored to membrane IEA
GO:0044459 plasma membrane part IDA

Function

ID Name Evidence
GO:0004871 signal transducer activity IMP
GO:0042803 protein homodimerization activity IPI

Process

ID Name Evidence
GO:0006959 humoral immune response TAS
GO:0007165 signal transduction IMP
GO:0007267 cell-cell signaling TAS
GO:0007275 multicellular organismal development TAS
GO:0008283 cell proliferation TAS
GO:0042113 B cell activation IEA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IMP
GO:0045087 innate immune response IEA
GO:0051607 defense response to virus IDA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following BST2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BST2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu15823 NM_004335 Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu15823
Accession Version NM_004335.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 543bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product bone marrow stromal antigen 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC033873.1, AI077344.1 and CB047887.1. On Sep 12, 2013 this sequence version replaced gi:7262372. Summary: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033873.1, AL560990.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGCATCTA CTTCGTATGA CTATTGCAGA GTGCCCATGG AAGACGGGGA TAAGCGCTGT 
AAGCTTCTGC TGGGGATAGG AATTCTGGTG CTCCTGATCA TCGTGATTCT GGGGGTGCCC
TTGATTATCT TCACCATCAA GGCCAACAGC GAGGCCTGCC GGGACGGCCT TCGGGCAGTG
ATGGAGTGTC GCAATGTCAC CCATCTCCTG CAACAAGAGC TGACCGAGGC CCAGAAGGGC
TTTCAGGATG TGGAGGCCCA GGCCGCCACC TGCAACCACA CTGTGATGGC CCTAATGGCT
TCCCTGGATG CAGAGAAGGC CCAAGGACAA AAGAAAGTGG AGGAGCTTGA GGGAGAGATC
ACTACATTAA ACCATAAGCT TCAGGACGCG TCTGCAGAGG TGGAGCGACT GAGAAGAGAA
AACCAGGTCT TAAGCGTGAG AATCGCGGAC AAGAAGTACT ACCCCAGCTC CCAGGACTCC
AGCTCCGCTG CGGCGCCCCA GCTGCTGATT GTGCTGCTGG GCCTCAGCGC TCTGCTGCAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_004326.1
CDS82..624
Misc Feature(1)40..42(+)
Misc Feature(2)142..225(+)
Misc Feature(3)289..>537(+)
Exon (1)1..366
Gene:BST2
Gene Synonym:
Exon (2)367..433
Gene:BST2
Gene Synonym:
Exon (3)434..494
Gene:BST2
Gene Synonym:
Exon (4)495..639
Gene:BST2
Gene Synonym:
Exon (5)640..1027
Gene:BST2
Gene Synonym:
Translation
Position Chain Variation Link

Target ORF information:

RefSeq Version NM_004335
Organism Homo sapiens (human)
Definition Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004335

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCATCTA CTTCGTATGA CTATTGCAGA GTGCCCATGG AAGACGGGGA TAAGCGCTGT 
AAGCTTCTGC TGGGGATAGG AATTCTGGTG CTCCTGATCA TCGTGATTCT GGGGGTGCCC
TTGATTATCT TCACCATCAA GGCCAACAGC GAGGCCTGCC GGGACGGCCT TCGGGCAGTG
ATGGAGTGTC GCAATGTCAC CCATCTCCTG CAACAAGAGC TGACCGAGGC CCAGAAGGGC
TTTCAGGATG TGGAGGCCCA GGCCGCCACC TGCAACCACA CTGTGATGGC CCTAATGGCT
TCCCTGGATG CAGAGAAGGC CCAAGGACAA AAGAAAGTGG AGGAGCTTGA GGGAGAGATC
ACTACATTAA ACCATAAGCT TCAGGACGCG TCTGCAGAGG TGGAGCGACT GAGAAGAGAA
AACCAGGTCT TAAGCGTGAG AATCGCGGAC AAGAAGTACT ACCCCAGCTC CCAGGACTCC
AGCTCCGCTG CGGCGCCCCA GCTGCTGATT GTGCTGCTGG GCCTCAGCGC TCTGCTGCAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface
Virology 449, 287-296 (2014)
Wang SM, Huang KJ and Wang CT.


book

CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric molecules
J. Biol. Chem. 289 (1), 1-12 (2014)
Petris G, Casini A, Sasset L, Cesaratto F, Bestagno M, Cereseto A and Burrone OR.


book

Herpes simplex virus 1 counteracts tetherin restriction via its virion host shutoff activity
J. Virol. 87 (24), 13115-13123 (2013)
Zenner HL, Mauricio R, Banting G and Crump CM.


book

Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M
J. Virol. 87 (24), 13124-13133 (2013)
Blondeau C, Pelchen-Matthews A, Mlcochova P, Marsh M, Milne RS and Towers GJ.


book

A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release
Retrovirology 10, 85 (2013)
Sauter D, Hotter D, Engelhart S, Giehler F, Kieser A, Kubisch C and Kirchhoff F.


book

Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry
Cell. Immunol. 236 (1-2), 6-16 (2005)
Vidal-Laliena M, Romero X, March S, Requena V, Petriz J and Engel P.


book

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways
Oncogene 22 (21), 3307-3318 (2003)
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.


book

Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells
Biochem. Biophys. Res. Commun. 258 (3), 583-591 (1999)
Ohtomo T, Sugamata Y, Ozaki Y, Ono K, Yoshimura Y, Kawai S, Koishihara Y, Ozaki S, Kosaka M, Hirano T and Tsuchiya M.


book

Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans
Gene 165 (2), 329-330 (1995)
Furuya Y, Takasawa S, Yonekura H, Tanaka T, Takahara J and Okamoto H.


book

Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth
Genomics 26 (3), 527-534 (1995)
Ishikawa J, Kaisho T, Tomizawa H, Lee BO, Kobune Y, Inazawa J, Oritani K, Itoh M, Ochi T and Ishihara K.


 
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