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TBXAS1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TBXAS1
Entrez Gene ID 6916
Full Name thromboxane A synthase 1 (platelet)
Synonyms BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
General protein information
Preferred Names
thromboxane-A synthase
Names
thromboxane-A synthase
TXA synthase
cytochrome P450 5A1
platelet, cytochrome P450, subfamily V
cytochrome P450, family 5, subfamily A, polypeptide 1
thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
NP_001052.2
NP_001124438.1
NP_001159725.1
NP_001159726.1
NP_112246.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34-q35

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. lac of sum
Disorder MIM:

274180

Disorder Html: Thromboxane synthase deficiency (2); Ghosal syndrome, 231095 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011516544 XP_011514846 thromboxane-A synthase isoform X1
NM_001061 NP_001052 thromboxane-A synthase isoform 1
NM_030984 NP_112246 thromboxane-A synthase isoform 2
NM_001166253 NP_001159725 thromboxane-A synthase isoform 3
NM_001130966 NP_001124438 thromboxane-A synthase isoform 1
NM_001166254 NP_001159726 thromboxane-A synthase isoform 4



Homo sapiens (human) TBXAS1 NP_001052.2
Canis lupus familiaris (dog) TBXAS1 XP_539887.2
Bos taurus (cattle) TBXAS1 NP_001039492.1
Mus musculus (house mouse) Tbxas1 NP_035669.3
Rattus norvegicus (Norway rat) Tbxas1 NP_036819.1
Gallus gallus (chicken) TBXAS1 XP_416334.4
Danio rerio (zebrafish) tbxas1 NP_991172.1
Drosophila melanogaster (fruit fly) Cyp6a20 NP_611002.3
Drosophila melanogaster (fruit fly) Cyp6a2 NP_523628.1
Drosophila melanogaster (fruit fly) Cyp6a18 NP_651563.1
Drosophila melanogaster (fruit fly) Cyp6a8 NP_523749.2
Drosophila melanogaster (fruit fly) Cyp6a21 NP_611003.2
Drosophila melanogaster (fruit fly) Cyp6a9 NP_523748.2
Drosophila melanogaster (fruit fly) Cyp6a19 NP_611001.2
Drosophila melanogaster (fruit fly) Cyp6a23 NP_611000.2
Drosophila melanogaster (fruit fly) Cyp6a17 NP_652018.1
Drosophila melanogaster (fruit fly) Cyp6a22 NP_652075.1
Arabidopsis thaliana (thale cress) CYP711A1 NP_565617.2
Xenopus (Silurana) tropicalis (western clawed frog) tbxas1 NP_001164997.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TBXAS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBXAS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60882 XM_011516544 PREDICTED: Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu15640
NM_001061 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu15572 NM_030984 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $272.30
$389.00
OHu15608 NM_001166253 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $342.30
$489.00
OHu15640
NM_001130966 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu15621
NM_001166254 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu60882
Clone ID Related Accession (Same CDS sequence) XM_011516544
Accession Version XM_011516544.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1392bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007933.16) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTC CAAACTGAAT
CCAGAGATTT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011514846.1
CDS171..1562
Misc Feature(1)312..1538(+)
Translation

Target ORF information:

RefSeq Version XM_011516544
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516544

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTC CAAACTGAAT
CCAGAGATTT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15640
Clone ID Related Accession (Same CDS sequence) NM_001061 , NM_001130966
Accession Version NM_001061.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1605bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, BC041157.1 and BM673654.1. On Oct 14, 2009 this sequence version replaced gi:195972897. Transcript Variant: This variant (1, also known as TXS-I) encodes isoform 1, which is also known as isoform TXS-I. Both variants 1 and 3 encode the same isoform. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041157.1, M80647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001052.2
CDS236..1840
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1828(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..777
Gene:TBXAS1
Gene Synonym:
Exon (7)778..926
Gene:TBXAS1
Gene Synonym:
Exon (8)927..1057
Gene:TBXAS1
Gene Synonym:
Exon (9)1058..1372
Gene:TBXAS1
Gene Synonym:
Exon (10)1373..1464
Gene:TBXAS1
Gene Synonym:
Exon (11)1465..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1765
Gene:TBXAS1
Gene Synonym:
Exon (13)1766..2066
Gene:TBXAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001061
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001061

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15572
Clone ID Related Accession (Same CDS sequence) NM_030984
Accession Version NM_030984.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1383bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, M80646.1, AC004914.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. On Oct 14, 2009 this sequence version replaced gi:195972899. Transcript Variant: This variant (2, also known as TXS-II) lacks an alternate exon in the 3' coding region that encodes the heme binding site, compared to transcript variant 1. The encoded isoform (2, also known as isoform TXS-II) lacks thromboxane A synthase activity, has a distinct C-terminus, and is shorter than isoform 1. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M80646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTA CCGCTGCAGC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_112246.2
CDS236..1618
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1606(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..777
Gene:TBXAS1
Gene Synonym:
Exon (7)778..926
Gene:TBXAS1
Gene Synonym:
Exon (8)927..1057
Gene:TBXAS1
Gene Synonym:
Exon (9)1058..1372
Gene:TBXAS1
Gene Synonym:
Exon (10)1373..1464
Gene:TBXAS1
Gene Synonym:
Exon (11)1465..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1903
Gene:TBXAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_030984
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_030984

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTA CCGCTGCAGC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15608
Clone ID Related Accession (Same CDS sequence) NM_001166253
Accession Version NM_001166253.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1743bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, AK296069.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (4) includes an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK296069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGCTTGGCC TTTTAATCAT GCAAGAGAGA
ATAAAAGGTC ACATGGGTGG CCAGCAGGCT CCACAAAGAA TTCCACCCAC CCGTTTGTCG
AAGCCGAGTG GTATCTATGT GAATCTCCAT TATGCCACTC TACCTTTCTG TATGGTTCCC
CTCATCAGCC AAGCCTGCGA CCTTCTCCTG GCTCATTTAA AACGCTATGC GGAATCTGGG
GACGCATTTG ACATCCAGAG GTGCTACTGC AATTACACCA CAGATGTGGT TGCCAGCGTC
GCCTTTGGCA CCCCGGTGGA CTCCTGGCAG GCCCCTGAGG ATCCCTTTGT GAAACACTGC
AAGCGTTTCT TCGAATTCTG CATCCCCAGA CCTATCCTGG TTTTACTCTT ATCATTTCCA
TCCATAATGG TCCCACTGGC CCGGATTTTG CCCAATAAGA ACCGAGACGA ACTGAATGGC
TTTTTTAACA AACTCATTAG GAATGTGATT GCCTTGCGGG ACCAGCAAGC TGCCGAAGAG
AGGCGGAGAG ACTTCCTCCA AATGGTCCTG GATGCCCGAC ATTCTGCAAG TCCCATGGGC
GTGCAAGACT TTGACATCGT CAGAGACGTT TTCTCCTCTA CTGGGTGCAA GCCGAACCCT
TCCCGGCAAC ACCAGCCCAG CCCTATGGCC AGGCCTTTGA CTGTGGATGA GATTGTGGGC
CAGGCCTTCA TCTTCCTCAT CGCTGGCTAT GAAATCATCA CCAACACACT TTCTTTTGCC
ACCTACCTAC TGGCCACCAA CCCTGACTGC CAAGAGAAGC TTCTGAGAGA GGTAGACGTT
TTTAAGGAGA AACACATGGC CCCTGAGTTC TGCAGCCTCG AGGAAGGCCT GCCCTATCTG
GACATGGTGA TTGCAGAGAC GCTGAGGATG TACCCGCCAG CTTTCAGATT CACACGGGAG
GCAGCTCAGG ACTGCGAGGT GCTGGGGCAG CGCATCCCCG CAGGCGCTGT GCTAGAGATG
GCCGTGGGTG CCCTGCACCA TGACCCTGAG CACTGGCCAA GCCCGGAGAC CTTCAACCCT
GAAAGGTTCA CGGCTGAGGC CCGGCAGCAG CACCGGCCCT TCACGTACCT GCCCTTCGGG
GCCGGCCCAC GGAGCTGCCT CGGGGTGCGT CTAGGGCTGC TTGAGGTCAA GTTGACACTG
CTCCACGTGC TGCACAAGTT CCGGTTCCAA GCCTGCCCTG AGACCCAGGT ACCGCTGCAG
CTAGAATCCA AATCTGCCCT AGGTCCAAAA AATGGTGTCT ATATCAAGAT CGTATCCCGC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159725.1
CDS236..1978
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1966(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..826
Gene:TBXAS1
Gene Synonym:
Exon (7)827..915
Gene:TBXAS1
Gene Synonym:
Exon (8)916..1064
Gene:TBXAS1
Gene Synonym:
Exon (9)1065..1195
Gene:TBXAS1
Gene Synonym:
Exon (10)1196..1510
Gene:TBXAS1
Gene Synonym:
Exon (11)1511..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1740
Gene:TBXAS1
Gene Synonym:
Exon (13)1741..1903
Gene:TBXAS1
Gene Synonym:
Exon (14)1904..2204
Gene:TBXAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001166253
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166253

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGCTTGGCC TTTTAATCAT GCAAGAGAGA
ATAAAAGGTC ACATGGGTGG CCAGCAGGCT CCACAAAGAA TTCCACCCAC CCGTTTGTCG
AAGCCGAGTG GTATCTATGT GAATCTCCAT TATGCCACTC TACCTTTCTG TATGGTTCCC
CTCATCAGCC AAGCCTGCGA CCTTCTCCTG GCTCATTTAA AACGCTATGC GGAATCTGGG
GACGCATTTG ACATCCAGAG GTGCTACTGC AATTACACCA CAGATGTGGT TGCCAGCGTC
GCCTTTGGCA CCCCGGTGGA CTCCTGGCAG GCCCCTGAGG ATCCCTTTGT GAAACACTGC
AAGCGTTTCT TCGAATTCTG CATCCCCAGA CCTATCCTGG TTTTACTCTT ATCATTTCCA
TCCATAATGG TCCCACTGGC CCGGATTTTG CCCAATAAGA ACCGAGACGA ACTGAATGGC
TTTTTTAACA AACTCATTAG GAATGTGATT GCCTTGCGGG ACCAGCAAGC TGCCGAAGAG
AGGCGGAGAG ACTTCCTCCA AATGGTCCTG GATGCCCGAC ATTCTGCAAG TCCCATGGGC
GTGCAAGACT TTGACATCGT CAGAGACGTT TTCTCCTCTA CTGGGTGCAA GCCGAACCCT
TCCCGGCAAC ACCAGCCCAG CCCTATGGCC AGGCCTTTGA CTGTGGATGA GATTGTGGGC
CAGGCCTTCA TCTTCCTCAT CGCTGGCTAT GAAATCATCA CCAACACACT TTCTTTTGCC
ACCTACCTAC TGGCCACCAA CCCTGACTGC CAAGAGAAGC TTCTGAGAGA GGTAGACGTT
TTTAAGGAGA AACACATGGC CCCTGAGTTC TGCAGCCTCG AGGAAGGCCT GCCCTATCTG
GACATGGTGA TTGCAGAGAC GCTGAGGATG TACCCGCCAG CTTTCAGATT CACACGGGAG
GCAGCTCAGG ACTGCGAGGT GCTGGGGCAG CGCATCCCCG CAGGCGCTGT GCTAGAGATG
GCCGTGGGTG CCCTGCACCA TGACCCTGAG CACTGGCCAA GCCCGGAGAC CTTCAACCCT
GAAAGGTTCA CGGCTGAGGC CCGGCAGCAG CACCGGCCCT TCACGTACCT GCCCTTCGGG
GCCGGCCCAC GGAGCTGCCT CGGGGTGCGT CTAGGGCTGC TTGAGGTCAA GTTGACACTG
CTCCACGTGC TGCACAAGTT CCGGTTCCAA GCCTGCCCTG AGACCCAGGT ACCGCTGCAG
CTAGAATCCA AATCTGCCCT AGGTCCAAAA AATGGTGTCT ATATCAAGAT CGTATCCCGC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15640
Clone ID Related Accession (Same CDS sequence) NM_001061 , NM_001130966
Accession Version NM_001130966.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1605bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014117.2, AK223466.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. On Oct 14, 2009 this sequence version replaced gi:195972895. Transcript Variant: This variant (3, also known as TXS-III) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1, also known as isoform TXS-I). CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001124438.1
CDS539..2143
Misc Feature(1)476..478(+)
Misc Feature(2)680..2131(+)
Exon (1)1..224
Gene:TBXAS1
Gene Synonym:
Exon (2)225..309
Gene:TBXAS1
Gene Synonym:
Exon (3)310..373
Gene:TBXAS1
Gene Synonym:
Exon (4)374..462
Gene:TBXAS1
Gene Synonym:
Exon (5)463..630
Gene:TBXAS1
Gene Synonym:
Exon (6)631..724
Gene:TBXAS1
Gene Synonym:
Exon (7)725..777
Gene:TBXAS1
Gene Synonym:
Exon (8)778..874
Gene:TBXAS1
Gene Synonym:
Exon (9)875..991
Gene:TBXAS1
Gene Synonym:
Exon (10)992..1080
Gene:TBXAS1
Gene Synonym:
Exon (11)1081..1229
Gene:TBXAS1
Gene Synonym:
Exon (12)1230..1360
Gene:TBXAS1
Gene Synonym:
Exon (13)1361..1675
Gene:TBXAS1
Gene Synonym:
Exon (14)1676..1767
Gene:TBXAS1
Gene Synonym:
Exon (15)1768..1905
Gene:TBXAS1
Gene Synonym:
Exon (16)1906..2068
Gene:TBXAS1
Gene Synonym:
Exon (17)2069..2369
Gene:TBXAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001130966
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001130966

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15621
Clone ID Related Accession (Same CDS sequence) NM_001166254
Accession Version NM_001166254.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1401bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 4
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014117.2 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014117.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGCTCA GAAAGCTGTA TGGACCTCTG TGTGGGTACT ATCTTGGTCG TCGGATGTTT 
ATTGTTATTT CTGAGCCAGA CATGATCAAG CAGGTGTTGG TTGAGAACTT CAGTAACTTT
ACCAACAGAA TGGCGTCGGG TTTGGAGTTC AAGTCGGTAG CCGACAGCGT TCTGTTTTTA
CGTGACAAAA GATGGGAAGA GGTCAGAGGT GCCCTGATGT CTGCTTTCAG TCCTGAAAAG
CTGAACGAGA TGGTTCCCCT CATCAGCCAA GCCTGCGACC TTCTCCTGGC TCATTTAAAA
CGCTATGCGG AATCTGGGGA CGCATTTGAC ATCCAGAGGT GCTACTGCAA TTACACCACA
GATGTGGTTG CCAGCGTCGC CTTTGGCACC CCGGTGGACT CCTGGCAGGC CCCTGAGGAT
CCCTTTGTGA AACACTGCAA GCGTTTCTTC GAATTCTGCA TCCCCAGACC TATCCTGGTT
TTACTCTTAT CATTTCCATC CATAATGGTC CCACTGGCCC GGATTTTGCC CAATAAGAAC
CGAGACGAAC TGAATGGCTT TTTTAACAAA CTCATTAGGA ATGTGATTGC CTTGCGGGAC
CAGCAAGCTG CCGAAGAGAG GCGGAGAGAC TTCCTCCAAA TGGTCCTGGA TGCCCGACAT
TCTGCAAGTC CCATGGGCGT GCAAGACTTT GACATCGTCA GAGACGTTTT CTCCTCTACT
GGGTGCAAGC CGAACCCTTC CCGGCAACAC CAGCCCAGCC CTATGGCCAG GCCTTTGACT
GTGGATGAGA TTGTGGGCCA GGCCTTCATC TTCCTCATCG CTGGCTATGA AATCATCACC
AACACACTTT CTTTTGCCAC CTACCTACTG GCCACCAACC CTGACTGCCA AGAGAAGCTT
CTGAGAGAGG TAGACGTTTT TAAGGAGAAA CACATGGCCC CTGAGTTCTG CAGCCTCGAG
GAAGGCCTGC CCTATCTGGA CATGGTGATT GCAGAGACGC TGAGGATGTA CCCGCCAGCT
TTCAGATTCA CACGGGAGGC AGCTCAGGAC TGCGAGGTGC TGGGGCAGCG CATCCCCGCA
GGCGCTGTGC TAGAGATGGC CGTGGGTGCC CTGCACCATG ACCCTGAGCA CTGGCCAAGC
CCGGAGACCT TCAACCCTGA AAGGTTCACG GCTGAGGCCC GGCAGCAGCA CCGGCCCTTC
ACGTACCTGC CCTTCGGGGC CGGCCCACGG AGCTGCCTCG GGGTGCGTCT AGGGCTGCTT
GAGGTCAAGT TGACACTGCT CCACGTGCTG CACAAGTTCC GGTTCCAAGC CTGCCCTGAG
ACCCAGGTAC CGCTGCAGCT AGAATCCAAA TCTGCCCTAG GTCCAAAAAA TGGTGTCTAT
ATCAAGATCG TATCCCGCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159726.1
CDS490..1890
Misc Feature(1)340..342(+)
Misc Feature(2)490..1878(+)
Exon (1)1..224
Gene:TBXAS1
Gene Synonym:
Exon (2)225..288
Gene:TBXAS1
Gene Synonym:
Exon (3)289..377
Gene:TBXAS1
Gene Synonym:
Exon (4)378..471
Gene:TBXAS1
Gene Synonym:
Exon (5)472..524
Gene:TBXAS1
Gene Synonym:
Exon (6)525..621
Gene:TBXAS1
Gene Synonym:
Exon (7)622..738
Gene:TBXAS1
Gene Synonym:
Exon (8)739..827
Gene:TBXAS1
Gene Synonym:
Exon (9)828..976
Gene:TBXAS1
Gene Synonym:
Exon (10)977..1107
Gene:TBXAS1
Gene Synonym:
Exon (11)1108..1422
Gene:TBXAS1
Gene Synonym:
Exon (12)1423..1514
Gene:TBXAS1
Gene Synonym:
Exon (13)1515..1652
Gene:TBXAS1
Gene Synonym:
Exon (14)1653..1815
Gene:TBXAS1
Gene Synonym:
Exon (15)1816..2116
Gene:TBXAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001166254
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166254

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGCTCA GAAAGCTGTA TGGACCTCTG TGTGGGTACT ATCTTGGTCG TCGGATGTTT 
ATTGTTATTT CTGAGCCAGA CATGATCAAG CAGGTGTTGG TTGAGAACTT CAGTAACTTT
ACCAACAGAA TGGCGTCGGG TTTGGAGTTC AAGTCGGTAG CCGACAGCGT TCTGTTTTTA
CGTGACAAAA GATGGGAAGA GGTCAGAGGT GCCCTGATGT CTGCTTTCAG TCCTGAAAAG
CTGAACGAGA TGGTTCCCCT CATCAGCCAA GCCTGCGACC TTCTCCTGGC TCATTTAAAA
CGCTATGCGG AATCTGGGGA CGCATTTGAC ATCCAGAGGT GCTACTGCAA TTACACCACA
GATGTGGTTG CCAGCGTCGC CTTTGGCACC CCGGTGGACT CCTGGCAGGC CCCTGAGGAT
CCCTTTGTGA AACACTGCAA GCGTTTCTTC GAATTCTGCA TCCCCAGACC TATCCTGGTT
TTACTCTTAT CATTTCCATC CATAATGGTC CCACTGGCCC GGATTTTGCC CAATAAGAAC
CGAGACGAAC TGAATGGCTT TTTTAACAAA CTCATTAGGA ATGTGATTGC CTTGCGGGAC
CAGCAAGCTG CCGAAGAGAG GCGGAGAGAC TTCCTCCAAA TGGTCCTGGA TGCCCGACAT
TCTGCAAGTC CCATGGGCGT GCAAGACTTT GACATCGTCA GAGACGTTTT CTCCTCTACT
GGGTGCAAGC CGAACCCTTC CCGGCAACAC CAGCCCAGCC CTATGGCCAG GCCTTTGACT
GTGGATGAGA TTGTGGGCCA GGCCTTCATC TTCCTCATCG CTGGCTATGA AATCATCACC
AACACACTTT CTTTTGCCAC CTACCTACTG GCCACCAACC CTGACTGCCA AGAGAAGCTT
CTGAGAGAGG TAGACGTTTT TAAGGAGAAA CACATGGCCC CTGAGTTCTG CAGCCTCGAG
GAAGGCCTGC CCTATCTGGA CATGGTGATT GCAGAGACGC TGAGGATGTA CCCGCCAGCT
TTCAGATTCA CACGGGAGGC AGCTCAGGAC TGCGAGGTGC TGGGGCAGCG CATCCCCGCA
GGCGCTGTGC TAGAGATGGC CGTGGGTGCC CTGCACCATG ACCCTGAGCA CTGGCCAAGC
CCGGAGACCT TCAACCCTGA AAGGTTCACG GCTGAGGCCC GGCAGCAGCA CCGGCCCTTC
ACGTACCTGC CCTTCGGGGC CGGCCCACGG AGCTGCCTCG GGGTGCGTCT AGGGCTGCTT
GAGGTCAAGT TGACACTGCT CCACGTGCTG CACAAGTTCC GGTTCCAAGC CTGCCCTGAG
ACCCAGGTAC CGCTGCAGCT AGAATCCAAA TCTGCCCTAG GTCCAAAAAA TGGTGTCTAT
ATCAAGATCG TATCCCGCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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