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TBXAS1 thromboxane A synthase 1 (platelet) [Homo sapiens (human)]

Gene Symbol TBXAS1
Entrez Gene ID 6916
Full Name thromboxane A synthase 1 (platelet)
Synonyms BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
General protein information
Preferred Names
thromboxane-A synthase
Names
thromboxane-A synthase
TXA synthase
cytochrome P450 5A1
platelet, cytochrome P450, subfamily V
cytochrome P450, family 5, subfamily A, polypeptide 1
thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
NP_001052.2
NP_001124438.1
NP_001159725.1
NP_001159726.1
NP_112246.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34-q35

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. lac of sum
Disorder MIM:

274180

Disorder Html: Thromboxane synthase deficiency (2); Ghosal syndrome, 231095 (3)





The following TBXAS1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TBXAS1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60882 XM_011516544 PREDICTED: Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu15640 NM_001061 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.3
$379
OHu15572 NM_030984 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $389
OHu15608 NM_001166253 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $489
OHu15640 NM_001130966 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.3
$379
OHu15621 NM_001166254 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.3
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu60882
Accession Version XM_011516544.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1392bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_007933.16) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTC CAAACTGAAT
CCAGAGATTT AG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011514846.1
CDS171..1562
Misc Feature(1)312..1538(+)
Translation
Position Chain Variation Link
16 16 c, g dbSNP:548303628
20 20 c, g dbSNP:745445129
93 93 a, g dbSNP:753407831
99 99 c, t dbSNP:780793497
100 100 a, g dbSNP:745693905
104 104 -, c dbSNP:776200708
108 108 c, t dbSNP:769531447
110 110 a, c dbSNP:769116604
114 114 c, t dbSNP:566610125
115 115 a, g, t dbSNP:748243621
117 117 c, t dbSNP:534162963
118 118 a, g dbSNP:760943053
125 125 a, g dbSNP:765151274
130 130 c, t dbSNP:181789109
139 139 c, t dbSNP:763025742
142 142 c, g dbSNP:764125196
148 148 a, c dbSNP:751090270
149 149 a, g dbSNP:369114491
152 152 a, g dbSNP:766895277
153 153 c, g, t dbSNP:376526095
154 154 c, t dbSNP:780432038
161 161 a, c, t dbSNP:749644759
168 168 a, g dbSNP:370626399
170 170 a, g dbSNP:748539010
171 171 a, g dbSNP:374330294
172 172 c, t dbSNP:772228613
175 175 c, g, t dbSNP:148207522
183 183 c, t dbSNP:771248110
188 188 a, g dbSNP:775493645
198 198 c, t dbSNP:762830360
204 204 a, g dbSNP:758831195
215 215 c, t dbSNP:774376364
220 220 c, t dbSNP:761605340
223 223 c, t dbSNP:61733586
224 224 a, g dbSNP:201600575
229 229 c, t dbSNP:755828182
239 239 a, g dbSNP:765999355
240 240 g, t dbSNP:77579057
243 243 c, t dbSNP:755342498
247 247 c, t dbSNP:575146790
248 248 a, g dbSNP:374729467
249 249 a, g dbSNP:758813530
250 250 c, t dbSNP:777948651
252 252 c, t dbSNP:747082046
261 261 c, t dbSNP:146180153
274 274 c, t dbSNP:752977856
276 276 a, g dbSNP:759010950
277 277 c, t dbSNP:778130039
285 285 a, g dbSNP:137899905
289 289 c, t dbSNP:757418800
301 301 a, c, g dbSNP:564781973
302 302 c, t dbSNP:769874877
312 312 c, t dbSNP:778831274
323 323 g, t dbSNP:372284825
325 325 c, t dbSNP:377026714
331 331 c, t dbSNP:771838691
335 335 a, g dbSNP:766677167
338 338 c, t dbSNP:773135457
344 344 a, g dbSNP:760567947
351 351 c, t dbSNP:143035930
352 352 a, g, t dbSNP:6138
354 354 c, g dbSNP:759277158
366 366 a, g dbSNP:775012519
374 374 a, c dbSNP:762628361
381 381 c, t dbSNP:140463378
394 394 a, g dbSNP:774822571
395 395 c, t dbSNP:762472485
397 397 a, g dbSNP:768124977
401 401 a, t dbSNP:750883099
403 403 c, t dbSNP:756151303
408 408 a, g dbSNP:766440684
408 408 -, g dbSNP:762089088
416 416 c, t dbSNP:772585523
418 418 c, t dbSNP:140005285
423 423 c, t dbSNP:761127128
424 424 a, g, t dbSNP:193110720
427 427 a, g dbSNP:372928270
428 428 c, g, t dbSNP:776632713
436 436 c, t dbSNP:184269562
438 438 a, g dbSNP:149814692
447 447 a, g dbSNP:144789379
450 450 a, c dbSNP:767252885
455 455 c, t dbSNP:750224404
456 456 a, g dbSNP:756060703
462 462 a, g dbSNP:780050223
463 463 a, c dbSNP:753761062
470 470 a, g dbSNP:754565649
475 475 a, c, t dbSNP:370871916
489 489 a, g dbSNP:771726219
496 496 c, g dbSNP:536748649
508 508 -, cgt dbSNP:763408875
508 508 c, t dbSNP:139976441
509 509 a, g dbSNP:776535363
511 511 c, t dbSNP:545470216
512 512 a, g dbSNP:765253923
513 513 a, g dbSNP:752623907
515 515 g, t dbSNP:757931122
518 518 c, g dbSNP:145491642
522 522 c, t dbSNP:751251261
524 524 c, g dbSNP:756839668
529 529 c, t dbSNP:773309398
530 530 a, c, g, t dbSNP:41275018
536 536 c, t dbSNP:780540044
537 537 a, g dbSNP:368719678
538 538 a, g dbSNP:369045472
540 540 a, g dbSNP:774271298
542 542 c, t dbSNP:372829666
543 543 -, t dbSNP:769059666
543 543 a, g dbSNP:8192833
547 547 c, t dbSNP:776627683
549 549 g, t dbSNP:759417784
551 551 g, t dbSNP:769647611
556 556 a, g dbSNP:374952408
559 559 a, g dbSNP:762755305
560 560 c, t dbSNP:763711236
565 565 a, g dbSNP:751005900
566 566 a, t dbSNP:761582094
567 567 c, t dbSNP:767167593
570 570 a, g dbSNP:750007788
572 572 a, c dbSNP:540770195
577 577 g, t dbSNP:756499129
580 580 a, c, g dbSNP:549595955
587 587 c, g dbSNP:369644265
588 588 c, t dbSNP:755406302
593 593 a, g dbSNP:200508924
599 599 c, t dbSNP:748164764
611 611 a, g dbSNP:772223176
614 614 c, g dbSNP:142359181
620 620 c, t dbSNP:199666672
621 621 a, g dbSNP:769738510
623 623 a, g dbSNP:775130622
624 624 a, g dbSNP:753279904
626 626 g, t dbSNP:756857897
627 627 a, g dbSNP:142284603
631 631 c, t dbSNP:751688125
637 637 a, t dbSNP:757613487
638 638 c, g, t dbSNP:781271750
646 646 a, c dbSNP:543782716
648 648 c, t dbSNP:150999114
650 650 c, t dbSNP:371594766
651 651 a, g dbSNP:771992790
653 653 a, c dbSNP:5768
657 657 a, c dbSNP:6137
661 661 c, t dbSNP:374628335
663 663 a, g dbSNP:746537232
668 668 c, t dbSNP:770409673
675 675 c, t dbSNP:373695119
676 676 a, g dbSNP:150139510
679 679 a, g dbSNP:368121899
682 682 a, c, t dbSNP:775968061
683 683 a, g dbSNP:764689349
695 695 c, t dbSNP:201279773
704 704 c, t dbSNP:566317735
706 706 c, t dbSNP:767583237
713 713 c, g dbSNP:766601203
717 717 -, a dbSNP:750676023
717 717 c, t dbSNP:368219976
728 728 c, t dbSNP:758221656
731 731 a, c dbSNP:372676819
733 733 c, t dbSNP:751501421
749 749 c, t dbSNP:757190665
750 750 a, g dbSNP:372058761
752 752 -, cg dbSNP:760698812
752 752 c, t dbSNP:532367760
753 753 a, g dbSNP:769131779
755 755 c, g dbSNP:1042561
757 757 c, t dbSNP:779880193
763 763 a, c dbSNP:560818343
765 765 c, g dbSNP:138612126
766 766 c, t dbSNP:140278426
767 767 a, g dbSNP:762292195
770 770 a, g dbSNP:752730531
775 775 a, c dbSNP:773533669
776 776 c, t dbSNP:575820680
784 784 a, c dbSNP:766406648
785 785 c, t dbSNP:754081891
787 787 -, ct dbSNP:766421283
787 787 c, t dbSNP:267601314
794 794 a, t dbSNP:143125111
796 796 c, g dbSNP:137946697
800 800 c, t dbSNP:751367995
802 802 a, t dbSNP:757201633
809 809 c, t dbSNP:142313797
810 810 c, t dbSNP:547691074
811 811 c, g dbSNP:561110643
812 812 a, c dbSNP:755704969
816 816 c, g dbSNP:779684101
817 817 a, g dbSNP:748986878
819 819 -, g dbSNP:752651674
820 820 c, t dbSNP:754669979
821 821 -, cttcgaa dbSNP:758337568
824 824 c, t dbSNP:779201611
825 825 a, g dbSNP:748558139
830 830 a, c dbSNP:772258904
832 832 a, g dbSNP:773799620
833 833 c, t dbSNP:747425088
846 846 a, g dbSNP:376563307
848 848 c, t dbSNP:776662753
851 851 a, g dbSNP:528780783
852 852 a, g dbSNP:148258306
874 874 c, t dbSNP:554610146
889 889 g, t dbSNP:777345226
890 890 a, g dbSNP:546747241
893 893 c, t dbSNP:757958944
894 894 c, t dbSNP:778269471
895 895 a, g dbSNP:568328354
899 899 c, t dbSNP:572759693
907 907 a, g dbSNP:55856189
915 915 c, t dbSNP:200644306
916 916 a, g dbSNP:141602429
917 917 a, g dbSNP:769962039
921 921 a, g, t dbSNP:267601315
929 929 g, t dbSNP:768745298
942 942 a, g dbSNP:5769
946 946 c, t dbSNP:760550262
947 947 c, t dbSNP:770808858
951 951 a, g dbSNP:5770
960 960 a, t dbSNP:776731492
963 963 g, t dbSNP:376564758
969 969 c, t dbSNP:140774405
970 970 a, c, g dbSNP:145426879
987 987 a, g dbSNP:762726298
988 988 a, c dbSNP:756029091
989 989 a, g dbSNP:576991708
996 996 c, t dbSNP:761419784
997 997 a, g dbSNP:201485922
1002 1002 a, g dbSNP:750770036
1021 1021 c, t dbSNP:199733937
1023 1023 a, g dbSNP:756441005
1028 1028 c, g dbSNP:147264784
1029 1029 c, t dbSNP:766799764
1030 1030 a, g dbSNP:373090253
1048 1048 c, t dbSNP:755034312
1049 1049 a, g dbSNP:779114003
1050 1050 c, g dbSNP:748420937
1051 1051 a, g dbSNP:758689918
1052 1052 a, c, t dbSNP:781191549
1053 1053 a, g, t dbSNP:13306052
1059 1059 a, g dbSNP:200064479
1067 1067 c, t dbSNP:768208353
1071 1071 a, g dbSNP:773843069
1077 1077 a, g dbSNP:181415079
1079 1079 c, t dbSNP:186487639
1080 1080 a, g dbSNP:772851878
1091 1091 g, t dbSNP:770018092
1092 1092 a, g dbSNP:760976514
1101 1101 a, g dbSNP:371008827
1102 1102 a, c dbSNP:754350556
1105 1105 c, g, t dbSNP:202115912
1106 1106 a, g dbSNP:752812001
1112 1112 c, t dbSNP:532938264
1114 1114 -, c dbSNP:570470967
1117 1117 a, g dbSNP:758496547
1119 1119 a, c dbSNP:5771
1121 1121 -, ac dbSNP:749789077
1123 1123 -, ccagc dbSNP:769720072
1124 1124 c, t dbSNP:778147517
1125 1125 c, g dbSNP:747217876
1129 1129 c, g dbSNP:755886818
1134 1134 c, t dbSNP:779880644
1135 1135 c, g dbSNP:767320554
1137 1137 a, g dbSNP:768564320
1138 1138 c, t dbSNP:774212687
1140 1140 c, g dbSNP:747659359
1151 1151 a, g dbSNP:749775422
1164 1164 a, t dbSNP:772760722
1165 1165 c, t dbSNP:6140
1171 1171 g, t dbSNP:771239270
1172 1172 c, t dbSNP:149759095
1176 1176 a, g dbSNP:760178652
1193 1193 c, t dbSNP:771040362
1195 1195 c, t dbSNP:530584971
1202 1202 c, t dbSNP:763158770
1213 1213 c, t dbSNP:764187478
1230 1230 g, t dbSNP:145733169
1234 1234 c, g dbSNP:757474682
1236 1236 c, t dbSNP:779766759
1239 1239 c, g, t dbSNP:4529
1252 1252 a, g dbSNP:267601316
1255 1255 -, t dbSNP:774927838
1261 1261 a, g dbSNP:778850867
1277 1277 -, ga dbSNP:748473096
1285 1285 c, t dbSNP:748027473
1290 1290 a, g dbSNP:375792037
1301 1301 c, g dbSNP:374616816
1305 1305 a, c dbSNP:771618602
1307 1307 c, t dbSNP:13306054
1310 1310 a, g dbSNP:536936578
1316 1316 c, t dbSNP:201680614
1319 1319 -, t dbSNP:772450146
1322 1322 a, c dbSNP:368716167
1331 1331 c, g, t dbSNP:761978514
1332 1332 a, g dbSNP:3735354
1339 1339 g, t dbSNP:5760
1340 1340 c, g dbSNP:760866236
1342 1342 g, t dbSNP:765076182
1352 1352 g, t dbSNP:752484551
1356 1356 a, g, t dbSNP:758061526
1357 1357 a, t dbSNP:754978014
1359 1359 c, g dbSNP:201269727
1363 1363 c, t dbSNP:780814939
1372 1372 c, t dbSNP:78666490
1373 1373 a, g dbSNP:755811343
1374 1374 c, t dbSNP:143966863
1376 1376 a, g, t dbSNP:5761
1387 1387 c, t dbSNP:371738923
1388 1388 a, g dbSNP:548305901
1399 1399 a, g dbSNP:13306055
1407 1407 a, c, t dbSNP:200525534
1408 1408 a, g dbSNP:199422117
1416 1416 a, g dbSNP:754575232
1419 1419 c, g dbSNP:4528
1427 1427 a, c, t dbSNP:13306049
1428 1428 a, g dbSNP:150087656
1433 1433 a, g dbSNP:138413218
1442 1442 a, g dbSNP:202122899
1443 1443 c, t dbSNP:5762
1444 1444 a, g dbSNP:781107536
1447 1447 -, c dbSNP:766479574
1451 1451 c, t dbSNP:372503987
1452 1452 a, g dbSNP:2286199
1457 1457 c, t dbSNP:775711215
1458 1458 a, g dbSNP:4526
1462 1462 c, t dbSNP:531890821
1464 1464 c, t dbSNP:773326315
1467 1467 c, g dbSNP:760670865
1470 1470 a, g dbSNP:766046892
1475 1475 c, t dbSNP:4527
1476 1476 a, g dbSNP:759019222
1483 1483 -, ccctgca dbSNP:776636777
1483 1483 c, t dbSNP:568856853
1484 1484 c, t dbSNP:752344771
1486 1486 c, t dbSNP:758793578
1490 1490 c, t dbSNP:778078235
1493 1493 a, c, t dbSNP:752108207
1501 1501 a, g dbSNP:781397587
1503 1503 a, c dbSNP:745935423
1504 1504 a, c dbSNP:756173369
1508 1508 a, g dbSNP:780174620
1514 1514 a, c, t dbSNP:113298427
1516 1516 c, t dbSNP:773129737
1517 1517 a, g dbSNP:147299625
1518 1518 a, g dbSNP:8192868
1522 1522 a, c dbSNP:5763
1526 1526 c, g, t dbSNP:758990676
1529 1529 a, c dbSNP:775043078
1561 1561 a, c dbSNP:751548178
1579 1579 a, c dbSNP:191837425
1612 1612 c, t dbSNP:781240735
1638 1638 c, g dbSNP:113249182
1697 1697 a, t dbSNP:113849272
1701 1701 a, c dbSNP:373425608
1713 1713 c, t dbSNP:576122805
1723 1723 a, g dbSNP:753718231
1779 1779 a, g dbSNP:757106320
1798 1798 c, t dbSNP:779058906
1901 1901 c, t dbSNP:571801515
1922 1922 a, g dbSNP:137874003
1939 1939 c, t dbSNP:115245101
1991 1991 a, g dbSNP:77929903
2062 2062 a, g dbSNP:189901553
2067 2067 a, g dbSNP:541385036
2102 2102 a, g dbSNP:193187547
2104 2104 a, g dbSNP:746459186
2118 2118 a, g dbSNP:547970153
2120 2120 a, g dbSNP:545793589
2124 2124 a, c, g dbSNP:376408765
2127 2127 a, g dbSNP:549809682
2132 2132 a, c dbSNP:566200527
2143 2143 g, t dbSNP:150092733
2174 2174 a, g dbSNP:561754483
2180 2180 a, g dbSNP:185515962
2190 2190 c, g dbSNP:190815607
2256 2256 c, g dbSNP:762219987
2285 2285 a, c dbSNP:565617089
2296 2296 c, t dbSNP:138422610
2297 2297 a, g dbSNP:536562529
2333 2333 c, g dbSNP:71543351
2355 2355 a, t dbSNP:371253187
2356 2356 c, t dbSNP:773512048
2359 2359 c, t dbSNP:537150017
2393 2393 c, t dbSNP:373393400
2406 2406 a, g dbSNP:114885020
2407 2407 a, g dbSNP:373022891
2419 2419 c, t dbSNP:138153019
2446 2446 g, t dbSNP:77733242
2455 2455 c, t dbSNP:751282943
2502 2502 a, g dbSNP:756900150
2524 2524 c, t dbSNP:757835
2525 2525 a, g dbSNP:578249318
2540 2540 a, g dbSNP:545856211
2546 2546 c, t dbSNP:757834
2557 2557 c, t dbSNP:575948336
2611 2611 c, t dbSNP:143716003
2612 2612 a, g dbSNP:561805954
2621 2621 g, t dbSNP:767839337
2679 2679 c, g dbSNP:41315624
2771 2771 a, g dbSNP:547185999
2775 2775 c, g dbSNP:559261119
2777 2777 g, t dbSNP:368746172
2778 2778 a, c, t dbSNP:199684190
2779 2779 a, g dbSNP:756336279
2783 2783 a, g dbSNP:569974023
2793 2793 a, g dbSNP:769234141
2799 2799 g, t dbSNP:372834633

Target ORF information:

RefSeq Version XM_011516544
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011516544

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTC CAAACTGAAT
CCAGAGATTT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15640
Accession Version NM_001061.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1605bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, BC041157.1 and BM673654.1. On Oct 14, 2009 this sequence version replaced gi:195972897. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. Transcript Variant: This variant (1, also known as TXS-I) encodes isoform 1, which is also known as isoform TXS-I. Both variants 1 and 3 encode the same isoform. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041157.1, M80647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001052.2
CDS236..1840
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1828(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..777
Gene:TBXAS1
Gene Synonym:
Exon (7)778..926
Gene:TBXAS1
Gene Synonym:
Exon (8)927..1057
Gene:TBXAS1
Gene Synonym:
Exon (9)1058..1372
Gene:TBXAS1
Gene Synonym:
Exon (10)1373..1464
Gene:TBXAS1
Gene Synonym:
Exon (11)1465..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1765
Gene:TBXAS1
Gene Synonym:
Exon (13)1766..2066
Gene:TBXAS1
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:751050769
8 8 a, g dbSNP:150958431
24 24 g, t dbSNP:530155928
57 57 a, t dbSNP:763742782
81 81 c, g dbSNP:548303628
85 85 c, g dbSNP:745445129
158 158 a, g dbSNP:753407831
164 164 c, t dbSNP:780793497
165 165 a, g dbSNP:745693905
169 169 -, c dbSNP:776200708
173 173 c, t dbSNP:769531447
175 175 a, c dbSNP:769116604
179 179 c, t dbSNP:566610125
180 180 a, g, t dbSNP:748243621
182 182 c, t dbSNP:534162963
183 183 a, g dbSNP:760943053
190 190 a, g dbSNP:765151274
195 195 c, t dbSNP:181789109
204 204 c, t dbSNP:763025742
207 207 c, g dbSNP:764125196
213 213 a, c dbSNP:751090270
214 214 a, g dbSNP:369114491
217 217 a, g dbSNP:766895277
218 218 c, g, t dbSNP:376526095
219 219 c, t dbSNP:780432038
226 226 a, c, t dbSNP:749644759
233 233 a, g dbSNP:370626399
235 235 a, g dbSNP:748539010
236 236 a, g dbSNP:374330294
237 237 c, t dbSNP:772228613
240 240 c, g, t dbSNP:148207522
248 248 c, t dbSNP:771248110
253 253 a, g dbSNP:775493645
263 263 c, t dbSNP:762830360
269 269 a, g dbSNP:758831195
280 280 c, t dbSNP:774376364
285 285 c, t dbSNP:761605340
288 288 c, t dbSNP:61733586
289 289 a, g dbSNP:201600575
294 294 c, t dbSNP:755828182
304 304 a, g dbSNP:765999355
305 305 g, t dbSNP:77579057
308 308 c, t dbSNP:755342498
312 312 c, t dbSNP:575146790
313 313 a, g dbSNP:374729467
314 314 a, g dbSNP:758813530
315 315 c, t dbSNP:777948651
317 317 c, t dbSNP:747082046
326 326 c, t dbSNP:146180153
339 339 c, t dbSNP:752977856
341 341 a, g dbSNP:759010950
342 342 c, t dbSNP:778130039
350 350 a, g dbSNP:137899905
354 354 c, t dbSNP:757418800
366 366 a, c, g dbSNP:564781973
367 367 c, t dbSNP:769874877
377 377 c, t dbSNP:778831274
388 388 g, t dbSNP:372284825
390 390 c, t dbSNP:377026714
396 396 c, t dbSNP:771838691
400 400 a, g dbSNP:766677167
403 403 c, t dbSNP:773135457
409 409 a, g dbSNP:760567947
416 416 c, t dbSNP:143035930
417 417 a, g, t dbSNP:6138
419 419 c, g dbSNP:759277158
431 431 a, g dbSNP:775012519
439 439 a, c dbSNP:762628361
446 446 c, t dbSNP:140463378
459 459 a, g dbSNP:774822571
460 460 c, t dbSNP:762472485
462 462 a, g dbSNP:768124977
466 466 a, t dbSNP:750883099
468 468 c, t dbSNP:756151303
473 473 a, g dbSNP:766440684
473 473 -, g dbSNP:762089088
481 481 c, t dbSNP:772585523
483 483 c, t dbSNP:140005285
488 488 c, t dbSNP:761127128
489 489 a, g, t dbSNP:193110720
492 492 a, g dbSNP:372928270
493 493 c, g, t dbSNP:776632713
501 501 c, t dbSNP:184269562
503 503 a, g dbSNP:149814692
512 512 a, g dbSNP:144789379
515 515 a, c dbSNP:767252885
520 520 c, t dbSNP:750224404
521 521 a, g dbSNP:756060703
527 527 a, g dbSNP:780050223
528 528 a, c dbSNP:753761062
535 535 a, g dbSNP:754565649
540 540 a, c, t dbSNP:370871916
554 554 a, g dbSNP:771726219
561 561 c, g dbSNP:536748649
573 573 -, cgt dbSNP:763408875
573 573 c, t dbSNP:139976441
574 574 a, g dbSNP:776535363
576 576 c, t dbSNP:545470216
577 577 a, g dbSNP:765253923
578 578 a, g dbSNP:752623907
580 580 g, t dbSNP:757931122
583 583 c, g dbSNP:145491642
587 587 c, t dbSNP:751251261
589 589 c, g dbSNP:756839668
594 594 c, t dbSNP:773309398
595 595 a, c, g, t dbSNP:41275018
601 601 c, t dbSNP:780540044
602 602 a, g dbSNP:368719678
603 603 a, g dbSNP:369045472
605 605 a, g dbSNP:774271298
607 607 c, t dbSNP:372829666
608 608 -, t dbSNP:769059666
608 608 a, g dbSNP:8192833
612 612 c, t dbSNP:776627683
614 614 g, t dbSNP:759417784
616 616 g, t dbSNP:769647611
621 621 a, g dbSNP:374952408
624 624 a, g dbSNP:762755305
625 625 c, t dbSNP:763711236
630 630 a, g dbSNP:751005900
631 631 a, t dbSNP:761582094
632 632 c, t dbSNP:767167593
635 635 a, g dbSNP:750007788
637 637 a, c dbSNP:540770195
642 642 g, t dbSNP:756499129
645 645 a, c, g dbSNP:549595955
652 652 c, g dbSNP:369644265
653 653 c, t dbSNP:755406302
658 658 a, g dbSNP:200508924
664 664 c, t dbSNP:748164764
676 676 a, g dbSNP:772223176
679 679 c, g dbSNP:142359181
685 685 c, t dbSNP:199666672
686 686 a, g dbSNP:769738510
688 688 a, g dbSNP:775130622
689 689 a, g dbSNP:753279904
691 691 g, t dbSNP:756857897
692 692 a, g dbSNP:142284603
696 696 c, t dbSNP:751688125
702 702 a, t dbSNP:757613487
703 703 c, g, t dbSNP:781271750
711 711 a, c dbSNP:543782716
713 713 c, t dbSNP:150999114
715 715 c, t dbSNP:371594766
716 716 a, g dbSNP:771992790
718 718 a, c dbSNP:5768
722 722 a, c dbSNP:6137
726 726 c, t dbSNP:374628335
728 728 a, g dbSNP:746537232
733 733 c, t dbSNP:770409673
740 740 c, t dbSNP:373695119
741 741 a, g dbSNP:150139510
744 744 a, g dbSNP:368121899
747 747 a, c, t dbSNP:775968061
748 748 a, g dbSNP:764689349
760 760 c, t dbSNP:201279773
769 769 c, t dbSNP:566317735
771 771 c, t dbSNP:767583237
778 778 c, g dbSNP:766601203
782 782 -, a dbSNP:750676023
782 782 c, t dbSNP:368219976
793 793 c, t dbSNP:758221656
796 796 a, c dbSNP:372676819
798 798 c, t dbSNP:751501421
814 814 c, t dbSNP:757190665
815 815 a, g dbSNP:372058761
817 817 -, cg dbSNP:760698812
817 817 c, t dbSNP:532367760
818 818 a, g dbSNP:769131779
820 820 c, g dbSNP:1042561
822 822 c, t dbSNP:779880193
828 828 a, c dbSNP:560818343
830 830 c, g dbSNP:138612126
831 831 c, t dbSNP:140278426
832 832 a, g dbSNP:762292195
835 835 a, g dbSNP:752730531
840 840 a, c dbSNP:773533669
841 841 c, t dbSNP:575820680
849 849 a, c dbSNP:766406648
850 850 c, t dbSNP:754081891
852 852 -, ct dbSNP:766421283
852 852 c, t dbSNP:267601314
859 859 a, t dbSNP:143125111
861 861 c, g dbSNP:137946697
865 865 c, t dbSNP:751367995
867 867 a, t dbSNP:757201633
874 874 c, t dbSNP:142313797
875 875 c, t dbSNP:547691074
876 876 c, g dbSNP:561110643
877 877 a, c dbSNP:755704969
881 881 c, g dbSNP:779684101
882 882 a, g dbSNP:748986878
884 884 -, g dbSNP:752651674
885 885 c, t dbSNP:754669979
886 886 -, cttcgaa dbSNP:758337568
889 889 c, t dbSNP:779201611
890 890 a, g dbSNP:748558139
895 895 a, c dbSNP:772258904
897 897 a, g dbSNP:773799620
898 898 c, t dbSNP:747425088
911 911 a, g dbSNP:376563307
913 913 c, t dbSNP:776662753
916 916 a, g dbSNP:528780783
917 917 a, g dbSNP:148258306
939 939 c, t dbSNP:554610146
954 954 g, t dbSNP:777345226
955 955 a, g dbSNP:546747241
958 958 c, t dbSNP:757958944
959 959 c, t dbSNP:778269471
960 960 a, g dbSNP:568328354
964 964 c, t dbSNP:572759693
972 972 a, g dbSNP:55856189
980 980 c, t dbSNP:200644306
981 981 a, g dbSNP:141602429
982 982 a, g dbSNP:769962039
986 986 a, g, t dbSNP:267601315
994 994 g, t dbSNP:768745298
1007 1007 a, g dbSNP:5769
1011 1011 c, t dbSNP:760550262
1012 1012 c, t dbSNP:770808858
1016 1016 a, g dbSNP:5770
1025 1025 a, t dbSNP:776731492
1028 1028 g, t dbSNP:376564758
1034 1034 c, t dbSNP:140774405
1035 1035 a, c, g dbSNP:145426879
1052 1052 a, g dbSNP:762726298
1053 1053 a, c dbSNP:756029091
1054 1054 a, g dbSNP:576991708
1061 1061 c, t dbSNP:761419784
1062 1062 a, g dbSNP:201485922
1067 1067 a, g dbSNP:750770036
1086 1086 c, t dbSNP:199733937
1088 1088 a, g dbSNP:756441005
1093 1093 c, g dbSNP:147264784
1094 1094 c, t dbSNP:766799764
1095 1095 a, g dbSNP:373090253
1113 1113 c, t dbSNP:755034312
1114 1114 a, g dbSNP:779114003
1115 1115 c, g dbSNP:748420937
1116 1116 a, g dbSNP:758689918
1117 1117 a, c, t dbSNP:781191549
1118 1118 a, g, t dbSNP:13306052
1124 1124 a, g dbSNP:200064479
1132 1132 c, t dbSNP:768208353
1136 1136 a, g dbSNP:773843069
1142 1142 a, g dbSNP:181415079
1144 1144 c, t dbSNP:186487639
1145 1145 a, g dbSNP:772851878
1156 1156 g, t dbSNP:770018092
1157 1157 a, g dbSNP:760976514
1166 1166 a, g dbSNP:371008827
1167 1167 a, c dbSNP:754350556
1170 1170 c, g, t dbSNP:202115912
1171 1171 a, g dbSNP:752812001
1177 1177 c, t dbSNP:532938264
1179 1179 -, c dbSNP:570470967
1182 1182 a, g dbSNP:758496547
1184 1184 a, c dbSNP:5771
1186 1186 -, ac dbSNP:749789077
1188 1188 -, ccagc dbSNP:769720072
1189 1189 c, t dbSNP:778147517
1190 1190 c, g dbSNP:747217876
1194 1194 c, g dbSNP:755886818
1199 1199 c, t dbSNP:779880644
1200 1200 c, g dbSNP:767320554
1202 1202 a, g dbSNP:768564320
1203 1203 c, t dbSNP:774212687
1205 1205 c, g dbSNP:747659359
1216 1216 a, g dbSNP:749775422
1229 1229 a, t dbSNP:772760722
1230 1230 c, t dbSNP:6140
1236 1236 g, t dbSNP:771239270
1237 1237 c, t dbSNP:149759095
1241 1241 a, g dbSNP:760178652
1258 1258 c, t dbSNP:771040362
1260 1260 c, t dbSNP:530584971
1267 1267 c, t dbSNP:763158770
1278 1278 c, t dbSNP:764187478
1295 1295 g, t dbSNP:145733169
1299 1299 c, g dbSNP:757474682
1301 1301 c, t dbSNP:779766759
1304 1304 c, g, t dbSNP:4529
1317 1317 a, g dbSNP:267601316
1320 1320 -, t dbSNP:774927838
1326 1326 a, g dbSNP:778850867
1342 1342 -, ga dbSNP:748473096
1350 1350 c, t dbSNP:748027473
1355 1355 a, g dbSNP:375792037
1366 1366 c, g dbSNP:374616816
1370 1370 a, c dbSNP:771618602
1372 1372 c, t dbSNP:13306054
1375 1375 a, g dbSNP:536936578
1381 1381 c, t dbSNP:201680614
1384 1384 -, t dbSNP:772450146
1387 1387 a, c dbSNP:368716167
1396 1396 c, g, t dbSNP:761978514
1397 1397 a, g dbSNP:3735354
1404 1404 g, t dbSNP:5760
1405 1405 c, g dbSNP:760866236
1407 1407 g, t dbSNP:765076182
1417 1417 g, t dbSNP:752484551
1421 1421 a, g, t dbSNP:758061526
1422 1422 a, t dbSNP:754978014
1424 1424 c, g dbSNP:201269727
1428 1428 c, t dbSNP:780814939
1437 1437 c, t dbSNP:78666490
1438 1438 a, g dbSNP:755811343
1439 1439 c, t dbSNP:143966863
1441 1441 a, g, t dbSNP:5761
1452 1452 c, t dbSNP:371738923
1453 1453 a, g dbSNP:548305901
1464 1464 a, g dbSNP:13306055
1472 1472 a, c, t dbSNP:200525534
1473 1473 a, g dbSNP:199422117
1481 1481 a, g dbSNP:754575232
1484 1484 c, g dbSNP:4528
1492 1492 a, c, t dbSNP:13306049
1493 1493 a, g dbSNP:150087656
1498 1498 a, g dbSNP:138413218
1507 1507 a, g dbSNP:202122899
1508 1508 c, t dbSNP:5762
1509 1509 a, g dbSNP:781107536
1512 1512 -, c dbSNP:766479574
1516 1516 c, t dbSNP:372503987
1517 1517 a, g dbSNP:2286199
1522 1522 c, t dbSNP:775711215
1523 1523 a, g dbSNP:4526
1527 1527 c, t dbSNP:531890821
1529 1529 c, t dbSNP:773326315
1532 1532 c, g dbSNP:760670865
1535 1535 a, g dbSNP:766046892
1540 1540 c, t dbSNP:4527
1541 1541 a, g dbSNP:759019222
1548 1548 -, ccctgca dbSNP:776636777
1548 1548 c, t dbSNP:568856853
1549 1549 c, t dbSNP:752344771
1551 1551 c, t dbSNP:758793578
1555 1555 c, t dbSNP:778078235
1558 1558 a, c, t dbSNP:752108207
1566 1566 a, g dbSNP:781397587
1568 1568 a, c dbSNP:745935423
1569 1569 a, c dbSNP:756173369
1573 1573 a, g dbSNP:780174620
1579 1579 a, c, t dbSNP:113298427
1581 1581 c, t dbSNP:773129737
1582 1582 a, g dbSNP:147299625
1583 1583 a, g dbSNP:8192868
1587 1587 a, c dbSNP:5763
1591 1591 c, g, t dbSNP:758990676
1594 1594 a, c dbSNP:775043078
1603 1603 a, g dbSNP:773931087
1607 1607 a, c dbSNP:762103740
1608 1608 c, t dbSNP:200831963
1609 1609 a, g dbSNP:150820501
1613 1613 a, g dbSNP:756633372
1615 1615 a, g dbSNP:374788259
1617 1617 a, c dbSNP:753974178
1619 1619 a, c, g, t dbSNP:5764
1626 1626 a, g dbSNP:752926435
1627 1627 a, g dbSNP:757042013
1631 1631 c, t dbSNP:199972292
1632 1632 a, g dbSNP:41311778
1641 1641 c, t dbSNP:769763588
1642 1642 a, g dbSNP:369309793
1651 1651 c, g dbSNP:748806067
1655 1655 a, c, g, t dbSNP:149988492
1655 1655 -, g dbSNP:561266357
1658 1658 a, g dbSNP:535281830
1660 1660 c, g, t dbSNP:146745109
1661 1661 a, g dbSNP:139418226
1667 1667 c, t dbSNP:754348867
1668 1668 a, g dbSNP:371681873
1672 1672 a, c dbSNP:765376370
1673 1673 c, t dbSNP:753016461
1675 1675 c, t dbSNP:758631208
1679 1679 a, g, t dbSNP:199422116
1682 1682 a, g dbSNP:750234302
1686 1686 a, g dbSNP:755804900
1691 1691 a, g dbSNP:376254592
1694 1694 c, t dbSNP:144073388
1698 1698 c, t dbSNP:199422114
1703 1703 a, g dbSNP:749181041
1706 1706 a, g dbSNP:768208245
1721 1721 -, a dbSNP:767470646
1723 1723 c, t dbSNP:778383067
1724 1724 a, g dbSNP:747825074
1727 1727 a, c dbSNP:771761018
1730 1730 c, t dbSNP:772683389
1732 1732 c, g dbSNP:761124182
1734 1734 a, c dbSNP:80244437
1736 1736 c, t dbSNP:571830700
1739 1739 c, t dbSNP:539344678
1740 1740 a, g dbSNP:8192864
1758 1758 a, t dbSNP:200663004
1765 1765 a, g dbSNP:762870650
1770 1770 c, t dbSNP:13306050
1771 1771 a, g dbSNP:753638314
1772 1772 c, t dbSNP:754711666
1773 1773 c, t dbSNP:759354516
1779 1779 c, t dbSNP:752538699
1781 1781 a, g dbSNP:199906594
1797 1797 c, t dbSNP:777123902
1800 1800 a, g dbSNP:746731200
1804 1804 -, a dbSNP:748691839
1813 1813 g, t dbSNP:756965786
1818 1818 -, t dbSNP:772401079
1818 1818 a, g dbSNP:780924927
1825 1825 a, g dbSNP:200093421
1828 1828 c, t dbSNP:200481367
1829 1829 a, g dbSNP:185290287
1832 1832 a, t dbSNP:576405356
1834 1834 c, t dbSNP:202145405
1835 1835 c, t dbSNP:201159138
1836 1836 a, g dbSNP:761818836
1837 1837 c, g dbSNP:772299158
1844 1844 a, c dbSNP:773374959
1853 1853 c, t dbSNP:759357829
1854 1854 c, g, t dbSNP:200404222
1855 1855 a, g dbSNP:762784306
1858 1858 -, g dbSNP:747246663
1859 1859 a, c, g, t dbSNP:149010293
1859 1859 -, g dbSNP:773622146
1860 1860 c, g dbSNP:781010819
1861 1861 g, t dbSNP:750052024
1863 1863 a, g dbSNP:756539196
1864 1864 g, t dbSNP:780257012
1866 1866 g, t dbSNP:749876546
1871 1871 c, t dbSNP:769050092
1878 1878 a, g dbSNP:779422205
1881 1881 c, t dbSNP:748250240
1885 1885 a, g dbSNP:772099298
1889 1889 a, g dbSNP:773465067
1892 1892 c, t dbSNP:760866237
1900 1900 a, g dbSNP:769687125
1901 1901 a, g dbSNP:775141159
1902 1902 a, g dbSNP:762742576
1904 1904 a, g dbSNP:752629228
1906 1906 c, t dbSNP:763950341
1907 1907 -, gaa dbSNP:776938724
1907 1907 c, g dbSNP:751489459
1910 1910 a, g dbSNP:768103672
1914 1914 c, t dbSNP:761434746
1917 1917 -, a dbSNP:759498290
1919 1919 -, c dbSNP:769960042
1929 1929 c, t dbSNP:532177542
1935 1935 c, g dbSNP:767102429
1936 1936 -, t dbSNP:774411694
1937 1937 c, t dbSNP:550295650
1939 1939 c, g dbSNP:755720896
1942 1942 -, ag dbSNP:761901996
1947 1947 a, g dbSNP:779692621
1949 1949 a, c dbSNP:754170853
1955 1955 c, t dbSNP:755323687
1961 1961 a, g dbSNP:56091454
1962 1962 a, g dbSNP:5765
1966 1966 a, g dbSNP:748624063
1973 1973 c, t dbSNP:772191000
1985 1985 c, t dbSNP:777819493
1995 1995 c, t dbSNP:747322108
2005 2005 a, g dbSNP:13306051
2032 2032 c, t dbSNP:763605472
2041 2041 c, t dbSNP:548278115
2049 2049 c, g dbSNP:749058242
2052 2052 -, ctct dbSNP:376122476
2052 2052 c, t dbSNP:768454604
2059 2059 c, t dbSNP:774466897

Target ORF information:

RefSeq Version NM_001061
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001061

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15572
Accession Version NM_030984.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1383bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, M80646.1, AC004914.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. On Oct 14, 2009 this sequence version replaced gi:195972899. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. Transcript Variant: This variant (2, also known as TXS-II) lacks an alternate exon in the 3' coding region that encodes the heme binding site, compared to transcript variant 1. The encoded isoform (2, also known as isoform TXS-II) lacks thromboxane A synthase activity, has a distinct C-terminus, and is shorter than isoform 1. CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M80646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTA CCGCTGCAGC
TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_112246.2
CDS236..1618
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1606(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..777
Gene:TBXAS1
Gene Synonym:
Exon (7)778..926
Gene:TBXAS1
Gene Synonym:
Exon (8)927..1057
Gene:TBXAS1
Gene Synonym:
Exon (9)1058..1372
Gene:TBXAS1
Gene Synonym:
Exon (10)1373..1464
Gene:TBXAS1
Gene Synonym:
Exon (11)1465..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1903
Gene:TBXAS1
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:751050769
8 8 a, g dbSNP:150958431
24 24 g, t dbSNP:530155928
57 57 a, t dbSNP:763742782
81 81 c, g dbSNP:548303628
85 85 c, g dbSNP:745445129
158 158 a, g dbSNP:753407831
164 164 c, t dbSNP:780793497
165 165 a, g dbSNP:745693905
169 169 -, c dbSNP:776200708
173 173 c, t dbSNP:769531447
175 175 a, c dbSNP:769116604
179 179 c, t dbSNP:566610125
180 180 a, g, t dbSNP:748243621
182 182 c, t dbSNP:534162963
183 183 a, g dbSNP:760943053
190 190 a, g dbSNP:765151274
195 195 c, t dbSNP:181789109
204 204 c, t dbSNP:763025742
207 207 c, g dbSNP:764125196
213 213 a, c dbSNP:751090270
214 214 a, g dbSNP:369114491
217 217 a, g dbSNP:766895277
218 218 c, g, t dbSNP:376526095
219 219 c, t dbSNP:780432038
226 226 a, c, t dbSNP:749644759
233 233 a, g dbSNP:370626399
235 235 a, g dbSNP:748539010
236 236 a, g dbSNP:374330294
237 237 c, t dbSNP:772228613
240 240 c, g, t dbSNP:148207522
248 248 c, t dbSNP:771248110
253 253 a, g dbSNP:775493645
263 263 c, t dbSNP:762830360
269 269 a, g dbSNP:758831195
280 280 c, t dbSNP:774376364
285 285 c, t dbSNP:761605340
288 288 c, t dbSNP:61733586
289 289 a, g dbSNP:201600575
294 294 c, t dbSNP:755828182
304 304 a, g dbSNP:765999355
305 305 g, t dbSNP:77579057
308 308 c, t dbSNP:755342498
312 312 c, t dbSNP:575146790
313 313 a, g dbSNP:374729467
314 314 a, g dbSNP:758813530
315 315 c, t dbSNP:777948651
317 317 c, t dbSNP:747082046
326 326 c, t dbSNP:146180153
339 339 c, t dbSNP:752977856
341 341 a, g dbSNP:759010950
342 342 c, t dbSNP:778130039
350 350 a, g dbSNP:137899905
354 354 c, t dbSNP:757418800
366 366 a, c, g dbSNP:564781973
367 367 c, t dbSNP:769874877
377 377 c, t dbSNP:778831274
388 388 g, t dbSNP:372284825
390 390 c, t dbSNP:377026714
396 396 c, t dbSNP:771838691
400 400 a, g dbSNP:766677167
403 403 c, t dbSNP:773135457
409 409 a, g dbSNP:760567947
416 416 c, t dbSNP:143035930
417 417 a, g, t dbSNP:6138
419 419 c, g dbSNP:759277158
431 431 a, g dbSNP:775012519
439 439 a, c dbSNP:762628361
446 446 c, t dbSNP:140463378
459 459 a, g dbSNP:774822571
460 460 c, t dbSNP:762472485
462 462 a, g dbSNP:768124977
466 466 a, t dbSNP:750883099
468 468 c, t dbSNP:756151303
473 473 a, g dbSNP:766440684
473 473 -, g dbSNP:762089088
481 481 c, t dbSNP:772585523
483 483 c, t dbSNP:140005285
488 488 c, t dbSNP:761127128
489 489 a, g, t dbSNP:193110720
492 492 a, g dbSNP:372928270
493 493 c, g, t dbSNP:776632713
501 501 c, t dbSNP:184269562
503 503 a, g dbSNP:149814692
512 512 a, g dbSNP:144789379
515 515 a, c dbSNP:767252885
520 520 c, t dbSNP:750224404
521 521 a, g dbSNP:756060703
527 527 a, g dbSNP:780050223
528 528 a, c dbSNP:753761062
535 535 a, g dbSNP:754565649
540 540 a, c, t dbSNP:370871916
554 554 a, g dbSNP:771726219
561 561 c, g dbSNP:536748649
573 573 -, cgt dbSNP:763408875
573 573 c, t dbSNP:139976441
574 574 a, g dbSNP:776535363
576 576 c, t dbSNP:545470216
577 577 a, g dbSNP:765253923
578 578 a, g dbSNP:752623907
580 580 g, t dbSNP:757931122
583 583 c, g dbSNP:145491642
587 587 c, t dbSNP:751251261
589 589 c, g dbSNP:756839668
594 594 c, t dbSNP:773309398
595 595 a, c, g, t dbSNP:41275018
601 601 c, t dbSNP:780540044
602 602 a, g dbSNP:368719678
603 603 a, g dbSNP:369045472
605 605 a, g dbSNP:774271298
607 607 c, t dbSNP:372829666
608 608 -, t dbSNP:769059666
608 608 a, g dbSNP:8192833
612 612 c, t dbSNP:776627683
614 614 g, t dbSNP:759417784
616 616 g, t dbSNP:769647611
621 621 a, g dbSNP:374952408
624 624 a, g dbSNP:762755305
625 625 c, t dbSNP:763711236
630 630 a, g dbSNP:751005900
631 631 a, t dbSNP:761582094
632 632 c, t dbSNP:767167593
635 635 a, g dbSNP:750007788
637 637 a, c dbSNP:540770195
642 642 g, t dbSNP:756499129
645 645 a, c, g dbSNP:549595955
652 652 c, g dbSNP:369644265
653 653 c, t dbSNP:755406302
658 658 a, g dbSNP:200508924
664 664 c, t dbSNP:748164764
676 676 a, g dbSNP:772223176
679 679 c, g dbSNP:142359181
685 685 c, t dbSNP:199666672
686 686 a, g dbSNP:769738510
688 688 a, g dbSNP:775130622
689 689 a, g dbSNP:753279904
691 691 g, t dbSNP:756857897
692 692 a, g dbSNP:142284603
696 696 c, t dbSNP:751688125
702 702 a, t dbSNP:757613487
703 703 c, g, t dbSNP:781271750
711 711 a, c dbSNP:543782716
713 713 c, t dbSNP:150999114
715 715 c, t dbSNP:371594766
716 716 a, g dbSNP:771992790
718 718 a, c dbSNP:5768
722 722 a, c dbSNP:6137
726 726 c, t dbSNP:374628335
728 728 a, g dbSNP:746537232
733 733 c, t dbSNP:770409673
740 740 c, t dbSNP:373695119
741 741 a, g dbSNP:150139510
744 744 a, g dbSNP:368121899
747 747 a, c, t dbSNP:775968061
748 748 a, g dbSNP:764689349
760 760 c, t dbSNP:201279773
769 769 c, t dbSNP:566317735
771 771 c, t dbSNP:767583237
778 778 c, g dbSNP:766601203
782 782 -, a dbSNP:750676023
782 782 c, t dbSNP:368219976
793 793 c, t dbSNP:758221656
796 796 a, c dbSNP:372676819
798 798 c, t dbSNP:751501421
814 814 c, t dbSNP:757190665
815 815 a, g dbSNP:372058761
817 817 -, cg dbSNP:760698812
817 817 c, t dbSNP:532367760
818 818 a, g dbSNP:769131779
820 820 c, g dbSNP:1042561
822 822 c, t dbSNP:779880193
828 828 a, c dbSNP:560818343
830 830 c, g dbSNP:138612126
831 831 c, t dbSNP:140278426
832 832 a, g dbSNP:762292195
835 835 a, g dbSNP:752730531
840 840 a, c dbSNP:773533669
841 841 c, t dbSNP:575820680
849 849 a, c dbSNP:766406648
850 850 c, t dbSNP:754081891
852 852 -, ct dbSNP:766421283
852 852 c, t dbSNP:267601314
859 859 a, t dbSNP:143125111
861 861 c, g dbSNP:137946697
865 865 c, t dbSNP:751367995
867 867 a, t dbSNP:757201633
874 874 c, t dbSNP:142313797
875 875 c, t dbSNP:547691074
876 876 c, g dbSNP:561110643
877 877 a, c dbSNP:755704969
881 881 c, g dbSNP:779684101
882 882 a, g dbSNP:748986878
884 884 -, g dbSNP:752651674
885 885 c, t dbSNP:754669979
886 886 -, cttcgaa dbSNP:758337568
889 889 c, t dbSNP:779201611
890 890 a, g dbSNP:748558139
895 895 a, c dbSNP:772258904
897 897 a, g dbSNP:773799620
898 898 c, t dbSNP:747425088
911 911 a, g dbSNP:376563307
913 913 c, t dbSNP:776662753
916 916 a, g dbSNP:528780783
917 917 a, g dbSNP:148258306
939 939 c, t dbSNP:554610146
954 954 g, t dbSNP:777345226
955 955 a, g dbSNP:546747241
958 958 c, t dbSNP:757958944
959 959 c, t dbSNP:778269471
960 960 a, g dbSNP:568328354
964 964 c, t dbSNP:572759693
972 972 a, g dbSNP:55856189
980 980 c, t dbSNP:200644306
981 981 a, g dbSNP:141602429
982 982 a, g dbSNP:769962039
986 986 a, g, t dbSNP:267601315
994 994 g, t dbSNP:768745298
1007 1007 a, g dbSNP:5769
1011 1011 c, t dbSNP:760550262
1012 1012 c, t dbSNP:770808858
1016 1016 a, g dbSNP:5770
1025 1025 a, t dbSNP:776731492
1028 1028 g, t dbSNP:376564758
1034 1034 c, t dbSNP:140774405
1035 1035 a, c, g dbSNP:145426879
1052 1052 a, g dbSNP:762726298
1053 1053 a, c dbSNP:756029091
1054 1054 a, g dbSNP:576991708
1061 1061 c, t dbSNP:761419784
1062 1062 a, g dbSNP:201485922
1067 1067 a, g dbSNP:750770036
1086 1086 c, t dbSNP:199733937
1088 1088 a, g dbSNP:756441005
1093 1093 c, g dbSNP:147264784
1094 1094 c, t dbSNP:766799764
1095 1095 a, g dbSNP:373090253
1113 1113 c, t dbSNP:755034312
1114 1114 a, g dbSNP:779114003
1115 1115 c, g dbSNP:748420937
1116 1116 a, g dbSNP:758689918
1117 1117 a, c, t dbSNP:781191549
1118 1118 a, g, t dbSNP:13306052
1124 1124 a, g dbSNP:200064479
1132 1132 c, t dbSNP:768208353
1136 1136 a, g dbSNP:773843069
1142 1142 a, g dbSNP:181415079
1144 1144 c, t dbSNP:186487639
1145 1145 a, g dbSNP:772851878
1156 1156 g, t dbSNP:770018092
1157 1157 a, g dbSNP:760976514
1166 1166 a, g dbSNP:371008827
1167 1167 a, c dbSNP:754350556
1170 1170 c, g, t dbSNP:202115912
1171 1171 a, g dbSNP:752812001
1177 1177 c, t dbSNP:532938264
1179 1179 -, c dbSNP:570470967
1182 1182 a, g dbSNP:758496547
1184 1184 a, c dbSNP:5771
1186 1186 -, ac dbSNP:749789077
1188 1188 -, ccagc dbSNP:769720072
1189 1189 c, t dbSNP:778147517
1190 1190 c, g dbSNP:747217876
1194 1194 c, g dbSNP:755886818
1199 1199 c, t dbSNP:779880644
1200 1200 c, g dbSNP:767320554
1202 1202 a, g dbSNP:768564320
1203 1203 c, t dbSNP:774212687
1205 1205 c, g dbSNP:747659359
1216 1216 a, g dbSNP:749775422
1229 1229 a, t dbSNP:772760722
1230 1230 c, t dbSNP:6140
1236 1236 g, t dbSNP:771239270
1237 1237 c, t dbSNP:149759095
1241 1241 a, g dbSNP:760178652
1258 1258 c, t dbSNP:771040362
1260 1260 c, t dbSNP:530584971
1267 1267 c, t dbSNP:763158770
1278 1278 c, t dbSNP:764187478
1295 1295 g, t dbSNP:145733169
1299 1299 c, g dbSNP:757474682
1301 1301 c, t dbSNP:779766759
1304 1304 c, g, t dbSNP:4529
1317 1317 a, g dbSNP:267601316
1320 1320 -, t dbSNP:774927838
1326 1326 a, g dbSNP:778850867
1342 1342 -, ga dbSNP:748473096
1350 1350 c, t dbSNP:748027473
1355 1355 a, g dbSNP:375792037
1366 1366 c, g dbSNP:374616816
1370 1370 a, c dbSNP:771618602
1372 1372 c, t dbSNP:13306054
1375 1375 a, g dbSNP:536936578
1381 1381 c, t dbSNP:201680614
1384 1384 -, t dbSNP:772450146
1387 1387 a, c dbSNP:368716167
1396 1396 c, g, t dbSNP:761978514
1397 1397 a, g dbSNP:3735354
1404 1404 g, t dbSNP:5760
1405 1405 c, g dbSNP:760866236
1407 1407 g, t dbSNP:765076182
1417 1417 g, t dbSNP:752484551
1421 1421 a, g, t dbSNP:758061526
1422 1422 a, t dbSNP:754978014
1424 1424 c, g dbSNP:201269727
1428 1428 c, t dbSNP:780814939
1437 1437 c, t dbSNP:78666490
1438 1438 a, g dbSNP:755811343
1439 1439 c, t dbSNP:143966863
1441 1441 a, g, t dbSNP:5761
1452 1452 c, t dbSNP:371738923
1453 1453 a, g dbSNP:548305901
1464 1464 a, g dbSNP:13306055
1472 1472 a, c, t dbSNP:200525534
1473 1473 a, g dbSNP:199422117
1481 1481 a, g dbSNP:754575232
1484 1484 c, g dbSNP:4528
1492 1492 a, c, t dbSNP:13306049
1493 1493 a, g dbSNP:150087656
1498 1498 a, g dbSNP:138413218
1507 1507 a, g dbSNP:202122899
1508 1508 c, t dbSNP:5762
1509 1509 a, g dbSNP:781107536
1512 1512 -, c dbSNP:766479574
1516 1516 c, t dbSNP:372503987
1517 1517 a, g dbSNP:2286199
1522 1522 c, t dbSNP:775711215
1523 1523 a, g dbSNP:4526
1527 1527 c, t dbSNP:531890821
1529 1529 c, t dbSNP:773326315
1532 1532 c, g dbSNP:760670865
1535 1535 a, g dbSNP:766046892
1540 1540 c, t dbSNP:4527
1541 1541 a, g dbSNP:759019222
1548 1548 -, ccctgca dbSNP:776636777
1548 1548 c, t dbSNP:568856853
1549 1549 c, t dbSNP:752344771
1551 1551 c, t dbSNP:758793578
1555 1555 c, t dbSNP:778078235
1558 1558 a, c, t dbSNP:752108207
1566 1566 a, g dbSNP:781397587
1568 1568 a, c dbSNP:745935423
1569 1569 a, c dbSNP:756173369
1573 1573 a, g dbSNP:780174620
1579 1579 a, c, t dbSNP:113298427
1581 1581 c, t dbSNP:773129737
1582 1582 a, g dbSNP:147299625
1583 1583 a, g dbSNP:8192868
1587 1587 a, c dbSNP:5763
1591 1591 c, g, t dbSNP:758990676
1594 1594 a, c dbSNP:775043078
1607 1607 c, t dbSNP:13306050
1608 1608 a, g dbSNP:753638314
1609 1609 c, t dbSNP:754711666
1610 1610 c, t dbSNP:759354516
1616 1616 c, t dbSNP:752538699
1618 1618 a, g dbSNP:199906594
1634 1634 c, t dbSNP:777123902
1637 1637 a, g dbSNP:746731200
1641 1641 -, a dbSNP:748691839
1650 1650 g, t dbSNP:756965786
1655 1655 -, t dbSNP:772401079
1655 1655 a, g dbSNP:780924927
1662 1662 a, g dbSNP:200093421
1665 1665 c, t dbSNP:200481367
1666 1666 a, g dbSNP:185290287
1669 1669 a, t dbSNP:576405356
1671 1671 c, t dbSNP:202145405
1672 1672 c, t dbSNP:201159138
1673 1673 a, g dbSNP:761818836
1674 1674 c, g dbSNP:772299158
1681 1681 a, c dbSNP:773374959
1690 1690 c, t dbSNP:759357829
1691 1691 c, g, t dbSNP:200404222
1692 1692 a, g dbSNP:762784306
1695 1695 -, g dbSNP:747246663
1696 1696 a, c, g, t dbSNP:149010293
1696 1696 -, g dbSNP:773622146
1697 1697 c, g dbSNP:781010819
1698 1698 g, t dbSNP:750052024
1700 1700 a, g dbSNP:756539196
1701 1701 g, t dbSNP:780257012
1703 1703 g, t dbSNP:749876546
1708 1708 c, t dbSNP:769050092
1715 1715 a, g dbSNP:779422205
1718 1718 c, t dbSNP:748250240
1722 1722 a, g dbSNP:772099298
1726 1726 a, g dbSNP:773465067
1729 1729 c, t dbSNP:760866237
1737 1737 a, g dbSNP:769687125
1738 1738 a, g dbSNP:775141159
1739 1739 a, g dbSNP:762742576
1741 1741 a, g dbSNP:752629228
1743 1743 c, t dbSNP:763950341
1744 1744 -, gaa dbSNP:776938724
1744 1744 c, g dbSNP:751489459
1747 1747 a, g dbSNP:768103672
1751 1751 c, t dbSNP:761434746
1754 1754 -, a dbSNP:759498290
1756 1756 -, c dbSNP:769960042
1766 1766 c, t dbSNP:532177542
1772 1772 c, g dbSNP:767102429
1773 1773 -, t dbSNP:774411694
1774 1774 c, t dbSNP:550295650
1776 1776 c, g dbSNP:755720896
1779 1779 -, ag dbSNP:761901996
1784 1784 a, g dbSNP:779692621
1786 1786 a, c dbSNP:754170853
1792 1792 c, t dbSNP:755323687
1798 1798 a, g dbSNP:56091454
1799 1799 a, g dbSNP:5765
1803 1803 a, g dbSNP:748624063
1810 1810 c, t dbSNP:772191000
1822 1822 c, t dbSNP:777819493
1832 1832 c, t dbSNP:747322108
1842 1842 a, g dbSNP:13306051
1869 1869 c, t dbSNP:763605472
1878 1878 c, t dbSNP:548278115
1886 1886 c, g dbSNP:749058242
1889 1889 -, ctct dbSNP:376122476
1889 1889 c, t dbSNP:768454604
1896 1896 c, t dbSNP:774466897

Target ORF information:

RefSeq Version NM_030984
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_030984

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTA CCGCTGCAGC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15608
Accession Version NM_001166253.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1743bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006021.2, AK296069.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. Transcript Variant: This variant (4) includes an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK296069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGCTTGGCC TTTTAATCAT GCAAGAGAGA
ATAAAAGGTC ACATGGGTGG CCAGCAGGCT CCACAAAGAA TTCCACCCAC CCGTTTGTCG
AAGCCGAGTG GTATCTATGT GAATCTCCAT TATGCCACTC TACCTTTCTG TATGGTTCCC
CTCATCAGCC AAGCCTGCGA CCTTCTCCTG GCTCATTTAA AACGCTATGC GGAATCTGGG
GACGCATTTG ACATCCAGAG GTGCTACTGC AATTACACCA CAGATGTGGT TGCCAGCGTC
GCCTTTGGCA CCCCGGTGGA CTCCTGGCAG GCCCCTGAGG ATCCCTTTGT GAAACACTGC
AAGCGTTTCT TCGAATTCTG CATCCCCAGA CCTATCCTGG TTTTACTCTT ATCATTTCCA
TCCATAATGG TCCCACTGGC CCGGATTTTG CCCAATAAGA ACCGAGACGA ACTGAATGGC
TTTTTTAACA AACTCATTAG GAATGTGATT GCCTTGCGGG ACCAGCAAGC TGCCGAAGAG
AGGCGGAGAG ACTTCCTCCA AATGGTCCTG GATGCCCGAC ATTCTGCAAG TCCCATGGGC
GTGCAAGACT TTGACATCGT CAGAGACGTT TTCTCCTCTA CTGGGTGCAA GCCGAACCCT
TCCCGGCAAC ACCAGCCCAG CCCTATGGCC AGGCCTTTGA CTGTGGATGA GATTGTGGGC
CAGGCCTTCA TCTTCCTCAT CGCTGGCTAT GAAATCATCA CCAACACACT TTCTTTTGCC
ACCTACCTAC TGGCCACCAA CCCTGACTGC CAAGAGAAGC TTCTGAGAGA GGTAGACGTT
TTTAAGGAGA AACACATGGC CCCTGAGTTC TGCAGCCTCG AGGAAGGCCT GCCCTATCTG
GACATGGTGA TTGCAGAGAC GCTGAGGATG TACCCGCCAG CTTTCAGATT CACACGGGAG
GCAGCTCAGG ACTGCGAGGT GCTGGGGCAG CGCATCCCCG CAGGCGCTGT GCTAGAGATG
GCCGTGGGTG CCCTGCACCA TGACCCTGAG CACTGGCCAA GCCCGGAGAC CTTCAACCCT
GAAAGGTTCA CGGCTGAGGC CCGGCAGCAG CACCGGCCCT TCACGTACCT GCCCTTCGGG
GCCGGCCCAC GGAGCTGCCT CGGGGTGCGT CTAGGGCTGC TTGAGGTCAA GTTGACACTG
CTCCACGTGC TGCACAAGTT CCGGTTCCAA GCCTGCCCTG AGACCCAGGT ACCGCTGCAG
CTAGAATCCA AATCTGCCCT AGGTCCAAAA AATGGTGTCT ATATCAAGAT CGTATCCCGC
TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001159725.1
CDS236..1978
Misc Feature(1)68..68(+)
Misc Feature(2)173..175(+)
Misc Feature(3)377..1966(+)
Exon (1)1..327
Gene:TBXAS1
Gene Synonym:
Exon (2)328..421
Gene:TBXAS1
Gene Synonym:
Exon (3)422..474
Gene:TBXAS1
Gene Synonym:
Exon (4)475..571
Gene:TBXAS1
Gene Synonym:
Exon (5)572..688
Gene:TBXAS1
Gene Synonym:
Exon (6)689..826
Gene:TBXAS1
Gene Synonym:
Exon (7)827..915
Gene:TBXAS1
Gene Synonym:
Exon (8)916..1064
Gene:TBXAS1
Gene Synonym:
Exon (9)1065..1195
Gene:TBXAS1
Gene Synonym:
Exon (10)1196..1510
Gene:TBXAS1
Gene Synonym:
Exon (11)1511..1602
Gene:TBXAS1
Gene Synonym:
Exon (12)1603..1740
Gene:TBXAS1
Gene Synonym:
Exon (13)1741..1903
Gene:TBXAS1
Gene Synonym:
Exon (14)1904..2204
Gene:TBXAS1
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:751050769
8 8 a, g dbSNP:150958431
24 24 g, t dbSNP:530155928
57 57 a, t dbSNP:763742782
81 81 c, g dbSNP:548303628
85 85 c, g dbSNP:745445129
158 158 a, g dbSNP:753407831
164 164 c, t dbSNP:780793497
165 165 a, g dbSNP:745693905
169 169 -, c dbSNP:776200708
173 173 c, t dbSNP:769531447
175 175 a, c dbSNP:769116604
179 179 c, t dbSNP:566610125
180 180 a, g, t dbSNP:748243621
182 182 c, t dbSNP:534162963
183 183 a, g dbSNP:760943053
190 190 a, g dbSNP:765151274
195 195 c, t dbSNP:181789109
204 204 c, t dbSNP:763025742
207 207 c, g dbSNP:764125196
213 213 a, c dbSNP:751090270
214 214 a, g dbSNP:369114491
217 217 a, g dbSNP:766895277
218 218 c, g, t dbSNP:376526095
219 219 c, t dbSNP:780432038
226 226 a, c, t dbSNP:749644759
233 233 a, g dbSNP:370626399
235 235 a, g dbSNP:748539010
236 236 a, g dbSNP:374330294
237 237 c, t dbSNP:772228613
240 240 c, g, t dbSNP:148207522
248 248 c, t dbSNP:771248110
253 253 a, g dbSNP:775493645
263 263 c, t dbSNP:762830360
269 269 a, g dbSNP:758831195
280 280 c, t dbSNP:774376364
285 285 c, t dbSNP:761605340
288 288 c, t dbSNP:61733586
289 289 a, g dbSNP:201600575
294 294 c, t dbSNP:755828182
304 304 a, g dbSNP:765999355
305 305 g, t dbSNP:77579057
308 308 c, t dbSNP:755342498
312 312 c, t dbSNP:575146790
313 313 a, g dbSNP:374729467
314 314 a, g dbSNP:758813530
315 315 c, t dbSNP:777948651
317 317 c, t dbSNP:747082046
326 326 c, t dbSNP:146180153
339 339 c, t dbSNP:752977856
341 341 a, g dbSNP:759010950
342 342 c, t dbSNP:778130039
350 350 a, g dbSNP:137899905
354 354 c, t dbSNP:757418800
366 366 a, c, g dbSNP:564781973
367 367 c, t dbSNP:769874877
377 377 c, t dbSNP:778831274
388 388 g, t dbSNP:372284825
390 390 c, t dbSNP:377026714
396 396 c, t dbSNP:771838691
400 400 a, g dbSNP:766677167
403 403 c, t dbSNP:773135457
409 409 a, g dbSNP:760567947
416 416 c, t dbSNP:143035930
417 417 a, g, t dbSNP:6138
419 419 c, g dbSNP:759277158
431 431 a, g dbSNP:775012519
439 439 a, c dbSNP:762628361
446 446 c, t dbSNP:140463378
459 459 a, g dbSNP:774822571
460 460 c, t dbSNP:762472485
462 462 a, g dbSNP:768124977
466 466 a, t dbSNP:750883099
468 468 c, t dbSNP:756151303
473 473 a, g dbSNP:766440684
473 473 -, g dbSNP:762089088
481 481 c, t dbSNP:772585523
483 483 c, t dbSNP:140005285
488 488 c, t dbSNP:761127128
489 489 a, g, t dbSNP:193110720
492 492 a, g dbSNP:372928270
493 493 c, g, t dbSNP:776632713
501 501 c, t dbSNP:184269562
503 503 a, g dbSNP:149814692
512 512 a, g dbSNP:144789379
515 515 a, c dbSNP:767252885
520 520 c, t dbSNP:750224404
521 521 a, g dbSNP:756060703
527 527 a, g dbSNP:780050223
528 528 a, c dbSNP:753761062
535 535 a, g dbSNP:754565649
540 540 a, c, t dbSNP:370871916
554 554 a, g dbSNP:771726219
561 561 c, g dbSNP:536748649
573 573 -, cgt dbSNP:763408875
573 573 c, t dbSNP:139976441
574 574 a, g dbSNP:776535363
576 576 c, t dbSNP:545470216
577 577 a, g dbSNP:765253923
578 578 a, g dbSNP:752623907
580 580 g, t dbSNP:757931122
583 583 c, g dbSNP:145491642
587 587 c, t dbSNP:751251261
589 589 c, g dbSNP:756839668
594 594 c, t dbSNP:773309398
595 595 a, c, g, t dbSNP:41275018
601 601 c, t dbSNP:780540044
602 602 a, g dbSNP:368719678
603 603 a, g dbSNP:369045472
605 605 a, g dbSNP:774271298
607 607 c, t dbSNP:372829666
608 608 -, t dbSNP:769059666
608 608 a, g dbSNP:8192833
612 612 c, t dbSNP:776627683
614 614 g, t dbSNP:759417784
616 616 g, t dbSNP:769647611
621 621 a, g dbSNP:374952408
624 624 a, g dbSNP:762755305
625 625 c, t dbSNP:763711236
630 630 a, g dbSNP:751005900
631 631 a, t dbSNP:761582094
632 632 c, t dbSNP:767167593
635 635 a, g dbSNP:750007788
637 637 a, c dbSNP:540770195
642 642 g, t dbSNP:756499129
645 645 a, c, g dbSNP:549595955
652 652 c, g dbSNP:369644265
653 653 c, t dbSNP:755406302
658 658 a, g dbSNP:200508924
664 664 c, t dbSNP:748164764
676 676 a, g dbSNP:772223176
679 679 c, g dbSNP:142359181
685 685 c, t dbSNP:199666672
686 686 a, g dbSNP:769738510
688 688 a, g dbSNP:775130622
689 689 c, g dbSNP:189999730
694 694 c, g dbSNP:148763147
723 723 a, g dbSNP:559884287
767 767 a, c dbSNP:377719655
777 777 a, c dbSNP:182583278
779 779 c, t dbSNP:6952940
780 780 c, t dbSNP:771250138
792 792 a, g dbSNP:779968590
796 796 c, g dbSNP:142393188
800 800 c, t dbSNP:550050768
809 809 g, t dbSNP:370661277
827 827 a, g dbSNP:753279904
829 829 g, t dbSNP:756857897
830 830 a, g dbSNP:142284603
834 834 c, t dbSNP:751688125
840 840 a, t dbSNP:757613487
841 841 c, g, t dbSNP:781271750
849 849 a, c dbSNP:543782716
851 851 c, t dbSNP:150999114
853 853 c, t dbSNP:371594766
854 854 a, g dbSNP:771992790
856 856 a, c dbSNP:5768
860 860 a, c dbSNP:6137
864 864 c, t dbSNP:374628335
866 866 a, g dbSNP:746537232
871 871 c, t dbSNP:770409673
878 878 c, t dbSNP:373695119
879 879 a, g dbSNP:150139510
882 882 a, g dbSNP:368121899
885 885 a, c, t dbSNP:775968061
886 886 a, g dbSNP:764689349
898 898 c, t dbSNP:201279773
907 907 c, t dbSNP:566317735
909 909 c, t dbSNP:767583237
916 916 c, g dbSNP:766601203
920 920 -, a dbSNP:750676023
920 920 c, t dbSNP:368219976
931 931 c, t dbSNP:758221656
934 934 a, c dbSNP:372676819
936 936 c, t dbSNP:751501421
952 952 c, t dbSNP:757190665
953 953 a, g dbSNP:372058761
955 955 -, cg dbSNP:760698812
955 955 c, t dbSNP:532367760
956 956 a, g dbSNP:769131779
958 958 c, g dbSNP:1042561
960 960 c, t dbSNP:779880193
966 966 a, c dbSNP:560818343
968 968 c, g dbSNP:138612126
969 969 c, t dbSNP:140278426
970 970 a, g dbSNP:762292195
973 973 a, g dbSNP:752730531
978 978 a, c dbSNP:773533669
979 979 c, t dbSNP:575820680
987 987 a, c dbSNP:766406648
988 988 c, t dbSNP:754081891
990 990 -, ct dbSNP:766421283
990 990 c, t dbSNP:267601314
997 997 a, t dbSNP:143125111
999 999 c, g dbSNP:137946697
1003 1003 c, t dbSNP:751367995
1005 1005 a, t dbSNP:757201633
1012 1012 c, t dbSNP:142313797
1013 1013 c, t dbSNP:547691074
1014 1014 c, g dbSNP:561110643
1015 1015 a, c dbSNP:755704969
1019 1019 c, g dbSNP:779684101
1020 1020 a, g dbSNP:748986878
1022 1022 -, g dbSNP:752651674
1023 1023 c, t dbSNP:754669979
1024 1024 -, cttcgaa dbSNP:758337568
1027 1027 c, t dbSNP:779201611
1028 1028 a, g dbSNP:748558139
1033 1033 a, c dbSNP:772258904
1035 1035 a, g dbSNP:773799620
1036 1036 c, t dbSNP:747425088
1049 1049 a, g dbSNP:376563307
1051 1051 c, t dbSNP:776662753
1054 1054 a, g dbSNP:528780783
1055 1055 a, g dbSNP:148258306
1077 1077 c, t dbSNP:554610146
1092 1092 g, t dbSNP:777345226
1093 1093 a, g dbSNP:546747241
1096 1096 c, t dbSNP:757958944
1097 1097 c, t dbSNP:778269471
1098 1098 a, g dbSNP:568328354
1102 1102 c, t dbSNP:572759693
1110 1110 a, g dbSNP:55856189
1118 1118 c, t dbSNP:200644306
1119 1119 a, g dbSNP:141602429
1120 1120 a, g dbSNP:769962039
1124 1124 a, g, t dbSNP:267601315
1132 1132 g, t dbSNP:768745298
1145 1145 a, g dbSNP:5769
1149 1149 c, t dbSNP:760550262
1150 1150 c, t dbSNP:770808858
1154 1154 a, g dbSNP:5770
1163 1163 a, t dbSNP:776731492
1166 1166 g, t dbSNP:376564758
1172 1172 c, t dbSNP:140774405
1173 1173 a, c, g dbSNP:145426879
1190 1190 a, g dbSNP:762726298
1191 1191 a, c dbSNP:756029091
1192 1192 a, g dbSNP:576991708
1199 1199 c, t dbSNP:761419784
1200 1200 a, g dbSNP:201485922
1205 1205 a, g dbSNP:750770036
1224 1224 c, t dbSNP:199733937
1226 1226 a, g dbSNP:756441005
1231 1231 c, g dbSNP:147264784
1232 1232 c, t dbSNP:766799764
1233 1233 a, g dbSNP:373090253
1251 1251 c, t dbSNP:755034312
1252 1252 a, g dbSNP:779114003
1253 1253 c, g dbSNP:748420937
1254 1254 a, g dbSNP:758689918
1255 1255 a, c, t dbSNP:781191549
1256 1256 a, g, t dbSNP:13306052
1262 1262 a, g dbSNP:200064479
1270 1270 c, t dbSNP:768208353
1274 1274 a, g dbSNP:773843069
1280 1280 a, g dbSNP:181415079
1282 1282 c, t dbSNP:186487639
1283 1283 a, g dbSNP:772851878
1294 1294 g, t dbSNP:770018092
1295 1295 a, g dbSNP:760976514
1304 1304 a, g dbSNP:371008827
1305 1305 a, c dbSNP:754350556
1308 1308 c, g, t dbSNP:202115912
1309 1309 a, g dbSNP:752812001
1315 1315 c, t dbSNP:532938264
1317 1317 -, c dbSNP:570470967
1320 1320 a, g dbSNP:758496547
1322 1322 a, c dbSNP:5771
1324 1324 -, ac dbSNP:749789077
1326 1326 -, ccagc dbSNP:769720072
1327 1327 c, t dbSNP:778147517
1328 1328 c, g dbSNP:747217876
1332 1332 c, g dbSNP:755886818
1337 1337 c, t dbSNP:779880644
1338 1338 c, g dbSNP:767320554
1340 1340 a, g dbSNP:768564320
1341 1341 c, t dbSNP:774212687
1343 1343 c, g dbSNP:747659359
1354 1354 a, g dbSNP:749775422
1367 1367 a, t dbSNP:772760722
1368 1368 c, t dbSNP:6140
1374 1374 g, t dbSNP:771239270
1375 1375 c, t dbSNP:149759095
1379 1379 a, g dbSNP:760178652
1396 1396 c, t dbSNP:771040362
1398 1398 c, t dbSNP:530584971
1405 1405 c, t dbSNP:763158770
1416 1416 c, t dbSNP:764187478
1433 1433 g, t dbSNP:145733169
1437 1437 c, g dbSNP:757474682
1439 1439 c, t dbSNP:779766759
1442 1442 c, g, t dbSNP:4529
1455 1455 a, g dbSNP:267601316
1458 1458 -, t dbSNP:774927838
1464 1464 a, g dbSNP:778850867
1480 1480 -, ga dbSNP:748473096
1488 1488 c, t dbSNP:748027473
1493 1493 a, g dbSNP:375792037
1504 1504 c, g dbSNP:374616816
1508 1508 a, c dbSNP:771618602
1510 1510 c, t dbSNP:13306054
1513 1513 a, g dbSNP:536936578
1519 1519 c, t dbSNP:201680614
1522 1522 -, t dbSNP:772450146
1525 1525 a, c dbSNP:368716167
1534 1534 c, g, t dbSNP:761978514
1535 1535 a, g dbSNP:3735354
1542 1542 g, t dbSNP:5760
1543 1543 c, g dbSNP:760866236
1545 1545 g, t dbSNP:765076182
1555 1555 g, t dbSNP:752484551
1559 1559 a, g, t dbSNP:758061526
1560 1560 a, t dbSNP:754978014
1562 1562 c, g dbSNP:201269727
1566 1566 c, t dbSNP:780814939
1575 1575 c, t dbSNP:78666490
1576 1576 a, g dbSNP:755811343
1577 1577 c, t dbSNP:143966863
1579 1579 a, g, t dbSNP:5761
1590 1590 c, t dbSNP:371738923
1591 1591 a, g dbSNP:548305901
1602 1602 a, g dbSNP:13306055
1610 1610 a, c, t dbSNP:200525534
1611 1611 a, g dbSNP:199422117
1619 1619 a, g dbSNP:754575232
1622 1622 c, g dbSNP:4528
1630 1630 a, c, t dbSNP:13306049
1631 1631 a, g dbSNP:150087656
1636 1636 a, g dbSNP:138413218
1645 1645 a, g dbSNP:202122899
1646 1646 c, t dbSNP:5762
1647 1647 a, g dbSNP:781107536
1650 1650 -, c dbSNP:766479574
1654 1654 c, t dbSNP:372503987
1655 1655 a, g dbSNP:2286199
1660 1660 c, t dbSNP:775711215
1661 1661 a, g dbSNP:4526
1665 1665 c, t dbSNP:531890821
1667 1667 c, t dbSNP:773326315
1670 1670 c, g dbSNP:760670865
1673 1673 a, g dbSNP:766046892
1678 1678 c, t dbSNP:4527
1679 1679 a, g dbSNP:759019222
1686 1686 -, ccctgca dbSNP:776636777
1686 1686 c, t dbSNP:568856853
1687 1687 c, t dbSNP:752344771
1689 1689 c, t dbSNP:758793578
1693 1693 c, t dbSNP:778078235
1696 1696 a, c, t dbSNP:752108207
1704 1704 a, g dbSNP:781397587
1706 1706 a, c dbSNP:745935423
1707 1707 a, c dbSNP:756173369
1711 1711 a, g dbSNP:780174620
1717 1717 a, c, t dbSNP:113298427
1719 1719 c, t dbSNP:773129737
1720 1720 a, g dbSNP:147299625
1721 1721 a, g dbSNP:8192868
1725 1725 a, c dbSNP:5763
1729 1729 c, g, t dbSNP:758990676
1732 1732 a, c dbSNP:775043078
1741 1741 a, g dbSNP:773931087
1745 1745 a, c dbSNP:762103740
1746 1746 c, t dbSNP:200831963
1747 1747 a, g dbSNP:150820501
1751 1751 a, g dbSNP:756633372
1753 1753 a, g dbSNP:374788259
1755 1755 a, c dbSNP:753974178
1757 1757 a, c, g, t dbSNP:5764
1764 1764 a, g dbSNP:752926435
1765 1765 a, g dbSNP:757042013
1769 1769 c, t dbSNP:199972292
1770 1770 a, g dbSNP:41311778
1779 1779 c, t dbSNP:769763588
1780 1780 a, g dbSNP:369309793
1789 1789 c, g dbSNP:748806067
1793 1793 a, c, g, t dbSNP:149988492
1793 1793 -, g dbSNP:561266357
1796 1796 a, g dbSNP:535281830
1798 1798 c, g, t dbSNP:146745109
1799 1799 a, g dbSNP:139418226
1805 1805 c, t dbSNP:754348867
1806 1806 a, g dbSNP:371681873
1810 1810 a, c dbSNP:765376370
1811 1811 c, t dbSNP:753016461
1813 1813 c, t dbSNP:758631208
1817 1817 a, g, t dbSNP:199422116
1820 1820 a, g dbSNP:750234302
1824 1824 a, g dbSNP:755804900
1829 1829 a, g dbSNP:376254592
1832 1832 c, t dbSNP:144073388
1836 1836 c, t dbSNP:199422114
1841 1841 a, g dbSNP:749181041
1844 1844 a, g dbSNP:768208245
1859 1859 -, a dbSNP:767470646
1861 1861 c, t dbSNP:778383067
1862 1862 a, g dbSNP:747825074
1865 1865 a, c dbSNP:771761018
1868 1868 c, t dbSNP:772683389
1870 1870 c, g dbSNP:761124182
1872 1872 a, c dbSNP:80244437
1874 1874 c, t dbSNP:571830700
1877 1877 c, t dbSNP:539344678
1878 1878 a, g dbSNP:8192864
1896 1896 a, t dbSNP:200663004
1903 1903 a, g dbSNP:762870650
1908 1908 c, t dbSNP:13306050
1909 1909 a, g dbSNP:753638314
1910 1910 c, t dbSNP:754711666
1911 1911 c, t dbSNP:759354516
1917 1917 c, t dbSNP:752538699
1919 1919 a, g dbSNP:199906594
1935 1935 c, t dbSNP:777123902
1938 1938 a, g dbSNP:746731200
1942 1942 -, a dbSNP:748691839
1951 1951 g, t dbSNP:756965786
1956 1956 -, t dbSNP:772401079
1956 1956 a, g dbSNP:780924927
1963 1963 a, g dbSNP:200093421
1966 1966 c, t dbSNP:200481367
1967 1967 a, g dbSNP:185290287
1970 1970 a, t dbSNP:576405356
1972 1972 c, t dbSNP:202145405
1973 1973 c, t dbSNP:201159138
1974 1974 a, g dbSNP:761818836
1975 1975 c, g dbSNP:772299158
1982 1982 a, c dbSNP:773374959
1991 1991 c, t dbSNP:759357829
1992 1992 c, g, t dbSNP:200404222
1993 1993 a, g dbSNP:762784306
1996 1996 -, g dbSNP:747246663
1997 1997 a, c, g, t dbSNP:149010293
1997 1997 -, g dbSNP:773622146
1998 1998 c, g dbSNP:781010819
1999 1999 g, t dbSNP:750052024
2001 2001 a, g dbSNP:756539196
2002 2002 g, t dbSNP:780257012
2004 2004 g, t dbSNP:749876546
2009 2009 c, t dbSNP:769050092
2016 2016 a, g dbSNP:779422205
2019 2019 c, t dbSNP:748250240
2023 2023 a, g dbSNP:772099298
2027 2027 a, g dbSNP:773465067
2030 2030 c, t dbSNP:760866237
2038 2038 a, g dbSNP:769687125
2039 2039 a, g dbSNP:775141159
2040 2040 a, g dbSNP:762742576
2042 2042 a, g dbSNP:752629228
2044 2044 c, t dbSNP:763950341
2045 2045 -, gaa dbSNP:776938724
2045 2045 c, g dbSNP:751489459
2048 2048 a, g dbSNP:768103672
2052 2052 c, t dbSNP:761434746
2055 2055 -, a dbSNP:759498290
2057 2057 -, c dbSNP:769960042
2067 2067 c, t dbSNP:532177542
2073 2073 c, g dbSNP:767102429
2074 2074 -, t dbSNP:774411694
2075 2075 c, t dbSNP:550295650
2077 2077 c, g dbSNP:755720896
2080 2080 -, ag dbSNP:761901996
2085 2085 a, g dbSNP:779692621
2087 2087 a, c dbSNP:754170853
2093 2093 c, t dbSNP:755323687
2099 2099 a, g dbSNP:56091454
2100 2100 a, g dbSNP:5765
2104 2104 a, g dbSNP:748624063
2111 2111 c, t dbSNP:772191000
2123 2123 c, t dbSNP:777819493
2133 2133 c, t dbSNP:747322108
2143 2143 a, g dbSNP:13306051
2170 2170 c, t dbSNP:763605472
2179 2179 c, t dbSNP:548278115
2187 2187 c, g dbSNP:749058242
2190 2190 -, ctct dbSNP:376122476
2190 2190 c, t dbSNP:768454604
2197 2197 c, t dbSNP:774466897

Target ORF information:

RefSeq Version NM_001166253
Organism Homo sapiens (human)
Definition Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166253

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGCTTGGCC TTTTAATCAT GCAAGAGAGA
ATAAAAGGTC ACATGGGTGG CCAGCAGGCT CCACAAAGAA TTCCACCCAC CCGTTTGTCG
AAGCCGAGTG GTATCTATGT GAATCTCCAT TATGCCACTC TACCTTTCTG TATGGTTCCC
CTCATCAGCC AAGCCTGCGA CCTTCTCCTG GCTCATTTAA AACGCTATGC GGAATCTGGG
GACGCATTTG ACATCCAGAG GTGCTACTGC AATTACACCA CAGATGTGGT TGCCAGCGTC
GCCTTTGGCA CCCCGGTGGA CTCCTGGCAG GCCCCTGAGG ATCCCTTTGT GAAACACTGC
AAGCGTTTCT TCGAATTCTG CATCCCCAGA CCTATCCTGG TTTTACTCTT ATCATTTCCA
TCCATAATGG TCCCACTGGC CCGGATTTTG CCCAATAAGA ACCGAGACGA ACTGAATGGC
TTTTTTAACA AACTCATTAG GAATGTGATT GCCTTGCGGG ACCAGCAAGC TGCCGAAGAG
AGGCGGAGAG ACTTCCTCCA AATGGTCCTG GATGCCCGAC ATTCTGCAAG TCCCATGGGC
GTGCAAGACT TTGACATCGT CAGAGACGTT TTCTCCTCTA CTGGGTGCAA GCCGAACCCT
TCCCGGCAAC ACCAGCCCAG CCCTATGGCC AGGCCTTTGA CTGTGGATGA GATTGTGGGC
CAGGCCTTCA TCTTCCTCAT CGCTGGCTAT GAAATCATCA CCAACACACT TTCTTTTGCC
ACCTACCTAC TGGCCACCAA CCCTGACTGC CAAGAGAAGC TTCTGAGAGA GGTAGACGTT
TTTAAGGAGA AACACATGGC CCCTGAGTTC TGCAGCCTCG AGGAAGGCCT GCCCTATCTG
GACATGGTGA TTGCAGAGAC GCTGAGGATG TACCCGCCAG CTTTCAGATT CACACGGGAG
GCAGCTCAGG ACTGCGAGGT GCTGGGGCAG CGCATCCCCG CAGGCGCTGT GCTAGAGATG
GCCGTGGGTG CCCTGCACCA TGACCCTGAG CACTGGCCAA GCCCGGAGAC CTTCAACCCT
GAAAGGTTCA CGGCTGAGGC CCGGCAGCAG CACCGGCCCT TCACGTACCT GCCCTTCGGG
GCCGGCCCAC GGAGCTGCCT CGGGGTGCGT CTAGGGCTGC TTGAGGTCAA GTTGACACTG
CTCCACGTGC TGCACAAGTT CCGGTTCCAA GCCTGCCCTG AGACCCAGGT ACCGCTGCAG
CTAGAATCCA AATCTGCCCT AGGTCCAAAA AATGGTGTCT ATATCAAGAT CGTATCCCGC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15640
Accession Version NM_001130966.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1605bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product thromboxane-A synthase isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014117.2, AK223466.1 and BM673654.1. This sequence is a reference standard in the RefSeqGene project. On Oct 14, 2009 this sequence version replaced gi:195972895. Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. Transcript Variant: This variant (3, also known as TXS-III) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1, also known as isoform TXS-I). CCDS Note: This CCDS representation uses the 5'-most in-frame start codon. It should be noted that this start codon is restricted to primate species (human, chimp, orangutan, rhesus and marmoset), whereas other mammalian species use a much better-conserved downstream start codon, which has a stronger Kozak signal. It is possible that the first start codon is used in human some of the time, while leaky scanning by ribosomes allows the second start codon to be used more of the time. The use of the latter would reduce the protein length by 1 aa. There is no experimental evidence indicating which start codon is preferably used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGATGGAAG CCTTGGGGTT TCTAAAATTG GAAGTGAATG GCCCCATGGT GACGGTGGCC 
CTGTCAGTGG CTCTCTTGGC CCTCCTGAAA TGGTACTCCA CATCAGCATT CTCAAGACTG
GAGAAGTTAG GCCTCAGACA TCCCAAGCCT TCTCCTTTCA TTGGAAACTT GACATTTTTC
CGCCAGGGTT TTTGGGAAAG CCAAATGGAG CTCAGAAAGC TGTATGGACC TCTGTGTGGG
TACTATCTTG GTCGTCGGAT GTTTATTGTT ATTTCTGAGC CAGACATGAT CAAGCAGGTG
TTGGTTGAGA ACTTCAGTAA CTTTACCAAC AGAATGGCGT CGGGTTTGGA GTTCAAGTCG
GTAGCCGACA GCGTTCTGTT TTTACGTGAC AAAAGATGGG AAGAGGTCAG AGGTGCCCTG
ATGTCTGCTT TCAGTCCTGA AAAGCTGAAC GAGATGGTTC CCCTCATCAG CCAAGCCTGC
GACCTTCTCC TGGCTCATTT AAAACGCTAT GCGGAATCTG GGGACGCATT TGACATCCAG
AGGTGCTACT GCAATTACAC CACAGATGTG GTTGCCAGCG TCGCCTTTGG CACCCCGGTG
GACTCCTGGC AGGCCCCTGA GGATCCCTTT GTGAAACACT GCAAGCGTTT CTTCGAATTC
TGCATCCCCA GACCTATCCT GGTTTTACTC TTATCATTTC CATCCATAAT GGTCCCACTG
GCCCGGATTT TGCCCAATAA GAACCGAGAC GAACTGAATG GCTTTTTTAA CAAACTCATT
AGGAATGTGA TTGCCTTGCG GGACCAGCAA GCTGCCGAAG AGAGGCGGAG AGACTTCCTC
CAAATGGTCC TGGATGCCCG ACATTCTGCA AGTCCCATGG GCGTGCAAGA CTTTGACATC
GTCAGAGACG TTTTCTCCTC TACTGGGTGC AAGCCGAACC CTTCCCGGCA ACACCAGCCC
AGCCCTATGG CCAGGCCTTT GACTGTGGAT GAGATTGTGG GCCAGGCCTT CATCTTCCTC
ATCGCTGGCT ATGAAATCAT CACCAACACA CTTTCTTTTG CCACCTACCT ACTGGCCACC
AACCCTGACT GCCAAGAGAA GCTTCTGAGA GAGGTAGACG TTTTTAAGGA GAAACACATG
GCCCCTGAGT TCTGCAGCCT CGAGGAAGGC CTGCCCTATC TGGACATGGT GATTGCAGAG
ACGCTGAGGA TGTACCCGCC AGCTTTCAGA TTCACACGGG AGGCAGCTCA GGACTGCGAG
GTGCTGGGGC AGCGCATCCC CGCAGGCGCT GTGCTAGAGA TGGCCGTGGG TGCCCTGCAC
CATGACCCTG AGCACTGGCC AAGCCCGGAG ACCTTCAACC CTGAAAGGTT CACGGCTGAG
GCCCGGCAGC AGCACCGGCC CTTCACGTAC CTGCCCTTCG GGGCCGGCCC ACGGAGCTGC
CTCGGGGTGC GTCTAGGGCT GCTTGAGGTC AAGTTGACAC TGCTCCACGT GCTGCACAAG
TTCCGGTTCC AAGCCTGCCC TGAGACCCAG GTACCGCTGC AGCTAGAATC CAAATCTGCC
CTAGGTCCAA AAAATGGTGT CTATATCAAG ATCGTATCCC GCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001124438.1
CDS539..2143
Misc Feature(1)476..478(+)
Misc Feature(2)680..2131(+)
Exon (1)1..224
Gene:TBXAS1
Gene Synonym:
Exon (2)225..309
Gene:TBXAS1
Gene Synonym:
Exon (3)310..373
Gene:TBXAS1
Gene Synonym:
Exon (4)374..462
Gene:TBXAS1
Gene Synonym:
Exon (5)463..630
Gene:TBXAS1
Gene Synonym:
Exon (6)631..724
Gene:TBXAS1
Gene Synonym:
Exon (7)725..777
Gene:TBXAS1
Gene Synonym:
Exon (8)778..874
Gene:TBXAS1
Gene Synonym:
Exon (9)875..991
Gene:TBXAS1
Gene Synonym:
Exon (10)992..1080
Gene:TBXAS1
Gene Synonym:
Exon (11)1081..1229
Gene:TBXAS1
Gene Synonym:
Exon (12)1230..1360
Gene:TBXAS1
Gene Synonym:
Exon (13)1361..1675
Gene:TBXAS1
Gene Synonym:
Exon (14)1676..1767
Gene:TBXAS1
Gene Synonym:
Exon (15)1768..1905
Gene:TBXAS1
Gene Synonym:
Exon (16)1906..2068
Gene:TBXAS1
Gene Synonym:
Exon (17)2069..2369
Gene:TBXAS1
Gene Synonym:
Translation
Position Chain Variation Link
39 39 c, t dbSNP:2254854
53 53 a, g dbSNP:191519450
70 70 c, t dbSNP:769317225
81 81 -, tgtg dbSNP:572338191
82 82 -, tg dbSNP:762170098
83 83 -, tg dbSNP:777484991
98 98 -, cg dbSNP:767921521
129 129 g, t dbSNP:1860509
177 177 g, t dbSNP:75846610
226 226 c, g dbSNP:576975154
241 241 c, t dbSNP:763575977
262 262 c, t dbSNP:73475929
324 324 c, t dbSNP:143907053
344 344 c, g dbSNP:552051025
418 418 g, t dbSNP:749541438
438 438 g, t dbSNP:148566456
449 449 c, t dbSNP:571025546
456 456 a, g dbSNP:538136088
467 467 c, t dbSNP:780793497
468 468 a, g dbSNP:745693905
472 472 -, c dbSNP:776200708
476 476 c, t dbSNP:769531447
478 478 a, c dbSNP:769116604
482 482 c, t dbSNP:566610125
483 483 a, g, t dbSNP:748243621
485 485 c, t dbSNP:534162963
486 486 a, g dbSNP:760943053
493 493 a, g dbSNP:765151274
498 498 c, t dbSNP:181789109
507 507 c, t dbSNP:763025742
510 510 c, g dbSNP:764125196
516 516 a, c dbSNP:751090270
517 517 a, g dbSNP:369114491
520 520 a, g dbSNP:766895277
521 521 c, g, t dbSNP:376526095
522 522 c, t dbSNP:780432038
529 529 a, c, t dbSNP:749644759
536 536 a, g dbSNP:370626399
538 538 a, g dbSNP:748539010
539 539 a, g dbSNP:374330294
540 540 c, t dbSNP:772228613
543 543 c, g, t dbSNP:148207522
551 551 c, t dbSNP:771248110
556 556 a, g dbSNP:775493645
566 566 c, t dbSNP:762830360
572 572 a, g dbSNP:758831195
583 583 c, t dbSNP:774376364
588 588 c, t dbSNP:761605340
591 591 c, t dbSNP:61733586
592 592 a, g dbSNP:201600575
597 597 c, t dbSNP:755828182
607 607 a, g dbSNP:765999355
608 608 g, t dbSNP:77579057
611 611 c, t dbSNP:755342498
615 615 c, t dbSNP:575146790
616 616 a, g dbSNP:374729467
617 617 a, g dbSNP:758813530
618 618 c, t dbSNP:777948651
620 620 c, t dbSNP:747082046
629 629 c, t dbSNP:146180153
642 642 c, t dbSNP:752977856
644 644 a, g dbSNP:759010950
645 645 c, t dbSNP:778130039
653 653 a, g dbSNP:137899905
657 657 c, t dbSNP:757418800
669 669 a, c, g dbSNP:564781973
670 670 c, t dbSNP:769874877
680 680 c, t dbSNP:778831274
691 691 g, t dbSNP:372284825
693 693 c, t dbSNP:377026714
699 699 c, t dbSNP:771838691
703 703 a, g dbSNP:766677167
706 706 c, t dbSNP:773135457
712 712 a, g dbSNP:760567947
719 719 c, t dbSNP:143035930
720 720 a, g, t dbSNP:6138
722 722 c, g dbSNP:759277158
734 734 a, g dbSNP:775012519
742 742 a, c dbSNP:762628361
749 749 c, t dbSNP:140463378
762 762 a, g dbSNP:774822571
763 763 c, t dbSNP:762472485
765 765 a, g dbSNP:768124977
769 769 a, t dbSNP:750883099
771 771 c, t dbSNP:756151303
776 776 a, g dbSNP:766440684
776 776 -, g dbSNP:762089088
784 784 c, t dbSNP:772585523
786 786 c, t dbSNP:140005285
791 791 c, t dbSNP:761127128
792 792 a, g, t dbSNP:193110720
795 795 a, g dbSNP:372928270
796 796 c, g, t dbSNP:776632713
804 804 c, t dbSNP:184269562
806 806 a, g dbSNP:149814692
815 815 a, g dbSNP:144789379
818 818 a, c dbSNP:767252885
823 823 c, t dbSNP:750224404
824 824 a, g dbSNP:756060703
830 830 a, g dbSNP:780050223
831 831 a, c dbSNP:753761062
838 838 a, g dbSNP:754565649
843 843 a, c, t dbSNP:370871916
857 857 a, g dbSNP:771726219
864 864 c, g dbSNP:536748649
876 876 -, cgt dbSNP:763408875
876 876 c, t dbSNP:139976441
877 877 a, g dbSNP:776535363
879 879 c, t dbSNP:545470216
880 880 a, g dbSNP:765253923
881 881 a, g dbSNP:752623907
883 883 g, t dbSNP:757931122
886 886 c, g dbSNP:145491642
890 890 c, t dbSNP:751251261
892 892 c, g dbSNP:756839668
897 897