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ACTC1 actin, alpha, cardiac muscle 1 [Homo sapiens (human)]

Gene Symbol ACTC1
Entrez Gene ID 70
Full Name actin, alpha, cardiac muscle 1
Synonyms ACTC, ASD5, CMD1R, CMH11, LVNC4
General protein information
Preferred Names
actin, alpha cardiac muscle 1
Names
actin, alpha cardiac muscle 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14

Summary Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

102540

Disorder Html: Cardiomyopathy, dilated, 1R, 613424 (3); Cardiomyopathy, familial





The following ACTC1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACTC1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19196 NM_005159 Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.3
$319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19196
Accession Version NM_005159.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1134bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product actin, alpha cardiac muscle 1 proprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB504220.1, BC009978.2, AK056592.1, CR737466.1 and AI222203.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2006 this sequence version replaced gi:46411161. Summary: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009978.2, AK129902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2159607 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTGTGACG ACGAGGAGAC CACCGCCCTG GTGTGCGACA ACGGCTCTGG GCTGGTGAAG 
GCCGGCTTTG CGGGCGATGA CGCGCCCCGC GCTGTCTTCC CGTCCATCGT GGGCCGCCCG
CGGCACCAGG GAGTTATGGT GGGTATGGGT CAGAAGGACT CCTACGTAGG TGATGAAGCC
CAGAGCAAGA GAGGCATCCT GACCCTGAAG TATCCCATCG AGCATGGTAT CATCACCAAC
TGGGACGACA TGGAGAAGAT CTGGCACCAC ACCTTCTACA ATGAGCTCCG TGTGGCTCCC
GAGGAGCACC CCACCCTGCT CACAGAGGCC CCGCTGAACC CCAAGGCCAA CCGGGAGAAG
ATGACTCAGA TCATGTTTGA GACCTTCAAT GTCCCTGCCA TGTACGTGGC CATCCAGGCA
GTGCTATCCC TGTATGCTTC TGGCCGTACC ACAGGCATTG TTCTGGACTC TGGGGATGGT
GTAACTCACA ATGTCCCCAT CTATGAGGGC TACGCTTTGC CCCATGCCAT CATGCGTCTG
GATCTGGCTG GTCGGGACCT CACTGACTAC CTCATGAAGA TCCTCACTGA GCGTGGCTAC
TCCTTTGTCA CCACTGCTGA ACGTGAAATT GTCCGTGACA TTAAAGAGAA GCTGTGCTAT
GTCGCCCTGG ATTTTGAGAA TGAGATGGCC ACAGCTGCCT CTTCCTCCTC CCTGGAGAAG
AGCTATGAAC TGCCTGATGG CCAAGTCATC ACTATTGGCA ATGAGCGCTT CCGCTGTCCT
GAGACACTCT TCCAGCCCTC CTTCATTGGT ATGGAATCTG CTGGCATCCA TGAAACAACT
TACAATAGCA TCATGAAGTG TGACATTGAT ATCCGCAAGG ACCTGTATGC CAACAATGTC
TTATCTGGAG GCACCACTAT GTACCCTGGT ATTGCTGATC GTATGCAGAA GGAAATCACT
GCTCTGGCTC CTAGCACCAT GAAGATTAAG ATTATTGCTC CCCCTGAGCG TAAATACTCT
GTCTGGATTG GGGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAAAT GTGGATTAGC
AAGCAAGAGT ACGATGAGGC AGGCCCATCC ATTGTCCACC GCAAATGCTT CTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_005150.1
CDS244..1377
Misc Feature(1)229..231(+)
Misc Feature(2)256..1374(+)
Misc Feature(3)271..792(+)
Misc Feature(4)280..720(+)
Misc Feature(5)499..501(+)
Exon (1)1..221
Gene:ACTC1
Gene Synonym:
Exon (2)222..372
Gene:ACTC1
Gene Synonym:
Exon (3)373..697
Gene:ACTC1
Gene Synonym:
Exon (4)698..859
Gene:ACTC1
Gene Synonym:
Exon (5)860..1051
Gene:ACTC1
Gene Synonym:
Exon (6)1052..1233
Gene:ACTC1
Gene Synonym:
Exon (7)1234..3693
Gene:ACTC1
Gene Synonym:
Translation
Position Chain Variation Link
7 7 a, g dbSNP:556400562
16 16 a, c dbSNP:370499568
126 126 c, t dbSNP:746796603
187 187 a, c, t dbSNP:113178069
190 190 c, t dbSNP:558792304
194 194 a, g dbSNP:139691739
210 210 g, t dbSNP:374056306
223 223 a, g dbSNP:771314720
226 226 c, t dbSNP:763073776
232 232 a, g dbSNP:372036883
239 239 c, t dbSNP:773272217
241 241 a, g dbSNP:769795473
243 243 a, g dbSNP:748380799
245 245 c, t dbSNP:781220417
250 250 c, g dbSNP:397517069
252 252 c, t dbSNP:535623090
253 253 c, g dbSNP:730880408
255 255 c, t dbSNP:768526036
262 262 a, t dbSNP:746748461
265 265 a, g dbSNP:730880390
266 266 c, g dbSNP:780088008
271 271 a, c dbSNP:397517057
273 273 c, g dbSNP:759084387
276 276 a, g dbSNP:368212410
299 299 -, ca dbSNP:730880387
300 300 a, g dbSNP:750021291
310 310 c, t dbSNP:193922681
315 315 a, g dbSNP:778572289
318 318 a, c, t dbSNP:144819872
319 319 a, g dbSNP:727504399
324 324 c, t dbSNP:753552901
326 326 c, t dbSNP:397517072
342 342 c, t dbSNP:763616452
349 349 a, g dbSNP:759988070
360 360 c, t dbSNP:751851323
363 363 a, g dbSNP:766934253
375 375 a, c dbSNP:774244503
385 385 g, t dbSNP:76508081
387 387 g, t dbSNP:770650598
404 404 c, t dbSNP:730880391
405 405 c, t dbSNP:748909803
408 408 c, t dbSNP:149432225
420 420 a, g dbSNP:755858258
423 423 c, t dbSNP:370322510
441 441 a, c dbSNP:780724030
453 453 a, g dbSNP:758865091
457 457 -, cccatcgagcatggtat dbSNP:387906585
460 460 a, g dbSNP:750951965
462 462 c, t dbSNP:376566924
472 472 a, g dbSNP:397517056
489 489 c, t dbSNP:373261583
503 503 g, t dbSNP:764208251
511 511 c, t dbSNP:121912676
513 513 c, t dbSNP:138812333
515 515 a, c dbSNP:730880037
518 518 -, tct dbSNP:730880388
524 524 a, g dbSNP:767734253
532 532 c, t dbSNP:759495229
537 537 a, g dbSNP:397517058
543 543 c, t dbSNP:141322728
544 544 a, g dbSNP:193922680
549 549 a, g dbSNP:773112383
552 552 c, t dbSNP:769303249
553 553 c, t dbSNP:397517059
576 576 a, g dbSNP:774767260
579 579 g, t dbSNP:780634156
598 598 c, g dbSNP:397517060
612 612 a, g dbSNP:768169477
615 615 c, g dbSNP:397517061
616 616 a, g dbSNP:121912677
626 626 c, t dbSNP:727504308
630 630 c, t dbSNP:746308321
642 642 c, t dbSNP:764630691
648 648 c, t dbSNP:181479041
678 678 c, t dbSNP:555107579
693 693 c, t dbSNP:536432438
699 699 c, t dbSNP:771310484
708 708 a, g dbSNP:397517062
718 718 a, g dbSNP:397517063
738 738 c, t dbSNP:765421643
739 739 c, g dbSNP:267606628
741 741 c, t dbSNP:370082904
743 743 c, t dbSNP:730880409
756 756 c, t dbSNP:145023222
759 759 c, t dbSNP:397517064
765 765 c, g dbSNP:149768491
766 766 -, c dbSNP:730880389
772 772 a, g dbSNP:730880392
779 779 g, t dbSNP:201921957
780 780 a, c, t dbSNP:750131288
784 784 c, g dbSNP:730880393
796 796 c, t dbSNP:397517065
806 806 c, t dbSNP:730880394
822 822 g, t dbSNP:730880395
845 845 c, t dbSNP:730880038
857 857 c, g dbSNP:751661762
865 865 c, t dbSNP:727505179
866 866 a, g dbSNP:142839840
876 876 c, t dbSNP:199947846
878 878 a, g dbSNP:397517067
882 882 c, t dbSNP:753599089
894 894 a, g dbSNP:763905846
895 895 c, t dbSNP:760269526
906 906 a, c, t dbSNP:766868624
921 921 g, t dbSNP:759078213
931 931 g, t dbSNP:773788749
938 938 c, t dbSNP:730880396
943 943 c, t dbSNP:730880397
956 956 c, t dbSNP:770397773
960 960 a, g dbSNP:369019849
982 982 a, g dbSNP:727505330
994 994 a, g dbSNP:730880039
998 998 c, t dbSNP:730880398
999 999 c, g, t dbSNP:371940910
1012 1012 c, t dbSNP:730880399
1019 1019 c, g dbSNP:199566566
1035 1035 c, t dbSNP:769158928
1036 1036 c, g dbSNP:727504323
1041 1041 c, t dbSNP:397517068
1049 1049 c, t dbSNP:397517071
1055 1055 c, t dbSNP:730880401
1064 1064 c, t dbSNP:538052265
1073 1073 a, g dbSNP:113513162
1086 1086 c, t dbSNP:368010998
1088 1088 a, g dbSNP:759156523
1090 1090 a, g dbSNP:751044644
1093 1093 a, t dbSNP:397517073
1101 1101 c, g dbSNP:766013863
1109 1109 c, t dbSNP:727504379
1116 1116 c, t dbSNP:762354030
1129 1129 a, c, t dbSNP:730880402
1132 1132 g, t dbSNP:121912675
1143 1143 c, t dbSNP:777285554
1146 1146 a, c, g dbSNP:138347995
1161 1161 a, t dbSNP:397517074
1170 1170 c, t dbSNP:2307493
1173 1173 c, t dbSNP:561081869
1183 1183 c, t dbSNP:543030688
1184 1184 a, g dbSNP:121912673
1185 1185 c, t dbSNP:778914066
1195 1195 a, g dbSNP:730880403
1210 1210 a, g dbSNP:771011464
1211 1211 c, t dbSNP:730880404
1229 1229 c, t dbSNP:730880410
1234 1234 a, t dbSNP:730880405
1237 1237 a, g dbSNP:749354463
1240 1240 c, g dbSNP:267606629
1241 1241 c, t dbSNP:730880406
1253 1253 a, g dbSNP:777875134
1254 1254 c, t dbSNP:769737060
1275 1275 c, g dbSNP:113835687
1281 1281 c, t dbSNP:748062476
1282 1282 a, g dbSNP:727505192
1296 1296 a, c, g dbSNP:151321743
1320 1320 c, t dbSNP:778288220
1326 1326 a, g dbSNP:754736799
1328 1328 a, c dbSNP:375435815
1331 1331 a, g dbSNP:121912674
1335 1335 c, t dbSNP:140261885
1341 1341 a, g dbSNP:758173419
1342 1342 a, g dbSNP:370256882
1355 1355 c, t dbSNP:730880407
1374 1374 c, t dbSNP:764683976
1380 1380 c, t dbSNP:727504415
1382 1382 c, g dbSNP:756594449
1389 1389 c, t dbSNP:753155881
1393 1393 c, t dbSNP:201258118
1397 1397 a, t dbSNP:143407466
1399 1399 c, t dbSNP:28730667
1403 1403 c, t dbSNP:373997876
1405 1405 a, t dbSNP:763198919
1406 1406 c, g dbSNP:773231264
1407 1407 g, t dbSNP:769780832
1412 1412 a, g dbSNP:748053539
1413 1413 a, t dbSNP:776430979
1416 1416 c, t dbSNP:3729758
1417 1417 a, g dbSNP:377546862
1422 1422 c, t dbSNP:374252209
1423 1423 a, c dbSNP:370919129
1463 1463 c, t dbSNP:778272368
1488 1488 c, t dbSNP:572031368
1492 1492 c, t dbSNP:367884939
1493 1493 a, g dbSNP:553652706
1498 1498 a, g dbSNP:535622574
1514 1514 a, t dbSNP:149031785
1525 1525 a, c dbSNP:549446281
1537 1537 a, g dbSNP:537551929
1572 1572 a, g dbSNP:759733343
1573 1573 c, t dbSNP:550947264
1574 1574 c, t dbSNP:758951219
1585 1585 a, g dbSNP:753985896
1590 1590 c, t dbSNP:766325228
1591 1591 a, g dbSNP:540240407
1601 1601 a, g dbSNP:551820554
1637 1637 g, t dbSNP:773298484
1646 1646 c, t dbSNP:74009720
1688 1688 a, g dbSNP:559979638
1711 1711 c, t dbSNP:762711685
1713 1713 a, g dbSNP:547800928
1765 1765 a, g dbSNP:1370154
1804 1804 c, t dbSNP:562187785
1849 1849 c, t dbSNP:1370155
1856 1856 c, t dbSNP:575737144
1860 1860 c, t dbSNP:755179019
1861 1861 c, t dbSNP:563713498
1895 1895 a, g dbSNP:115295911
1920 1920 a, t dbSNP:780758417
1922 1922 a, g dbSNP:147572632
1981 1981 g, t dbSNP:554012838
1997 1997 c, t dbSNP:770288632
2011 2011 c, g dbSNP:541805662
2065 2065 g, t dbSNP:116184851
2119 2119 c, g dbSNP:746732857
2134 2134 a, g dbSNP:78727649
2158 2158 a, g dbSNP:145085048
2196 2196 c, g dbSNP:561833169
2223 2223 a, g dbSNP:78596978
2226 2226 a, g dbSNP:374736519
2230 2230 c, t dbSNP:12904588
2233 2233 a, g dbSNP:79104010
2245 2245 g, t dbSNP:80139141
2252 2252 c, g dbSNP:73387693
2275 2275 a, g dbSNP:529572133
2295 2295 -, a dbSNP:767830411
2295 2295 -, a dbSNP:34323254
2295 2295 a, g dbSNP:201867681
2299 2299 g, t dbSNP:568596720
2312 2312 c, g dbSNP:766542832
2333 2333 c, t dbSNP:76039064
2360 2360 c, t dbSNP:549986676
2381 2381 a, g dbSNP:116034611
2416 2416 a, g dbSNP:589759
2453 2453 c, g dbSNP:7183591
2469 2469 a, c dbSNP:774287146
2491 2491 a, g dbSNP:545523213
2501 2501 a, g dbSNP:527277176
2510 2510 g, t dbSNP:750686235
2518 2518 g, t dbSNP:559901215
2552 2552 a, g dbSNP:542059917
2562 2562 a, g dbSNP:767706907
2596 2596 c, t dbSNP:139559367
2639 2639 c, g dbSNP:189725849
2680 2680 c, g dbSNP:764944789
2695 2695 g, t dbSNP:759530643
2745 2745 g, t dbSNP:776418537
2790 2790 c, t dbSNP:147815755
2810 2810 a, g dbSNP:563042919
2822 2822 c, g dbSNP:8037241
2836 2836 c, t dbSNP:149715837
2890 2890 c, t dbSNP:113063427
2926 2926 c, t dbSNP:746468354
2939 2939 g, t dbSNP:566025687
2966 2966 c, t dbSNP:553885411
2971 2971 c, t dbSNP:536122084
2985 2985 a, g dbSNP:112420026
2994 2994 a, g dbSNP:181221098
2998 2998 a, t dbSNP:189953579
3000 3000 a, g dbSNP:773045876
3017 3017 g, t dbSNP:771869878
3041 3041 a, c dbSNP:534200384
3049 3049 c, t dbSNP:573910835
3051 3051 c, t dbSNP:112660730
3059 3059 a, g dbSNP:533021
3109 3109 c, g dbSNP:750495564
3110 3110 c, t dbSNP:749876681
3120 3120 c, t dbSNP:551847673
3147 3147 g, t dbSNP:527397732
3151 3151 a, g, t dbSNP:756269270
3158 3158 c, t dbSNP:560065427
3169 3169 a, g dbSNP:772562230
3172 3172 a, t dbSNP:750526983
3179 3179 c, t dbSNP:563318028
3180 3180 -, gc dbSNP:779572361
3180 3180 a, g dbSNP:541476797
3213 3213 c, t dbSNP:529727545
3220 3220 c, g dbSNP:572595291
3231 3231 c, t dbSNP:562747106
3255 3255 c, t dbSNP:117033977
3256 3256 c, t dbSNP:577101643
3266 3266 a, g dbSNP:565085900
3268 3268 c, t dbSNP:546234337
3270 3270 c, t dbSNP:185151197
3274 3274 c, t dbSNP:554104818
3296 3296 a, g dbSNP:557782296
3317 3317 c, t dbSNP:574521280
3319 3319 a, c dbSNP:181638011
3359 3359 c, t dbSNP:757475343
3400 3400 c, t dbSNP:751723291
3430 3430 g, t dbSNP:79955486
3463 3463 c, t dbSNP:570663792
3466 3466 c, t dbSNP:755303963
3467 3467 a, g dbSNP:604689
3468 3468 a, g dbSNP:112920084
3469 3469 a, g dbSNP:142735669
3564 3564 a, c dbSNP:538181640
3579 3579 a, g dbSNP:188953722
3581 3581 c, t dbSNP:184599823
3652 3652 c, t dbSNP:140004011

Target ORF information:

RefSeq Version NM_005159
Organism Homo sapiens (human)
Definition Homo sapiens actin, alpha, cardiac muscle 1 (ACTC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005159

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTGTGACG ACGAGGAGAC CACCGCCCTG GTGTGCGACA ACGGCTCTGG GCTGGTGAAG 
GCCGGCTTTG CGGGCGATGA CGCGCCCCGC GCTGTCTTCC CGTCCATCGT GGGCCGCCCG
CGGCACCAGG GAGTTATGGT GGGTATGGGT CAGAAGGACT CCTACGTAGG TGATGAAGCC
CAGAGCAAGA GAGGCATCCT GACCCTGAAG TATCCCATCG AGCATGGTAT CATCACCAAC
TGGGACGACA TGGAGAAGAT CTGGCACCAC ACCTTCTACA ATGAGCTCCG TGTGGCTCCC
GAGGAGCACC CCACCCTGCT CACAGAGGCC CCGCTGAACC CCAAGGCCAA CCGGGAGAAG
ATGACTCAGA TCATGTTTGA GACCTTCAAT GTCCCTGCCA TGTACGTGGC CATCCAGGCA
GTGCTATCCC TGTATGCTTC TGGCCGTACC ACAGGCATTG TTCTGGACTC TGGGGATGGT
GTAACTCACA ATGTCCCCAT CTATGAGGGC TACGCTTTGC CCCATGCCAT CATGCGTCTG
GATCTGGCTG GTCGGGACCT CACTGACTAC CTCATGAAGA TCCTCACTGA GCGTGGCTAC
TCCTTTGTCA CCACTGCTGA ACGTGAAATT GTCCGTGACA TTAAAGAGAA GCTGTGCTAT
GTCGCCCTGG ATTTTGAGAA TGAGATGGCC ACAGCTGCCT CTTCCTCCTC CCTGGAGAAG
AGCTATGAAC TGCCTGATGG CCAAGTCATC ACTATTGGCA ATGAGCGCTT CCGCTGTCCT
GAGACACTCT TCCAGCCCTC CTTCATTGGT ATGGAATCTG CTGGCATCCA TGAAACAACT
TACAATAGCA TCATGAAGTG TGACATTGAT ATCCGCAAGG ACCTGTATGC CAACAATGTC
TTATCTGGAG GCACCACTAT GTACCCTGGT ATTGCTGATC GTATGCAGAA GGAAATCACT
GCTCTGGCTC CTAGCACCAT GAAGATTAAG ATTATTGCTC CCCCTGAGCG TAAATACTCT
GTCTGGATTG GGGGCTCCAT CCTGGCCTCT CTGTCCACCT TCCAGCAAAT GTGGATTAGC
AAGCAAGAGT ACGATGAGGC AGGCCCATCC ATTGTCCACC GCAAATGCTT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.