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TGFB1 transforming growth factor, beta 1 [Homo sapiens (human)]

Gene Symbol TGFB1
Entrez Gene ID 7040
Full Name transforming growth factor, beta 1
Synonyms CED, DPD1, LAP, TGFB, TGFbeta
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.1

Summary This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

190180

Disorder Html: Camurati-Engelmann disease, 131300 (3); {Cystic fibrosis lung





The following TGFB1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGFB1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60972 XM_011527242 PREDICTED: Homo sapiens transforming growth factor, beta 1 (TGFB1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $319
OHu27680 NM_000660 Homo sapiens transforming growth factor, beta 1 (TGFB1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector in pcDNA3.1+/C-(K)DYK $379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu60972
Accession Version XM_011527242.1
Sequence Information ORF Nucleotide Sequence (Length: 1176bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transforming growth factor beta-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011109.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGCAGGGTTC
ACTACCGGCC GCCGAGGTGA CCTGGCCACC ATTCATGGCA TGAACCGGCC TTTCCTGCTT
CTCATGGCCA CCCCGCTGGA GAGGGCCCAG CATCTGCAAA GCTCCCGGCA CCGCCGAGCC
CTGGACACCA ACTATTGCTT CAGCTCCACG GAGAAGAACT GCTGCGTGCG GCAGCTGTAC
ATTGACTTCC GCAAGGACCT CGGCTGGAAG TGGATCCACG AGCCCAAGGG CTACCATGCC
AACTTCTGCC TCGGGCCCTG CCCCTACATT TGGAGCCTGG ACACGCAGTA CAGCAAGGTC
CTGGCCCTGT ACAACCAGCA TAACCCGGGC GCCTCGGCGG CGCCGTGCTG CGTGCCGCAG
GCGCTGGAGC CGCTGCCCAT CGTGTACTAC GTGGGCCGCA AGCCCAAGGT GGAGCAGCTG
TCCAACATGA TCGTGCGCTC CTGCAAGTGC AGCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011525544.1
CDS883..2058
Misc Feature(1)964..1668(+)
Misc Feature(2)1753..2055(+)
Translation
Position Chain Variation Link
26 26 a, c dbSNP:12977628
46 46 a, c dbSNP:527614232
49 49 c, t dbSNP:560261580
50 50 c, t dbSNP:12977601
51 51 a, t dbSNP:12985978
56 56 c, g dbSNP:11466315
100 100 a, g dbSNP:778503498
105 105 a, g dbSNP:36185305
114 114 -, c dbSNP:1800999
121 121 -, c dbSNP:1799753
138 138 c, t dbSNP:200356936
201 201 c, t dbSNP:202216587
235 235 c, g dbSNP:11551223
241 241 a, g dbSNP:79132525
242 242 a, g dbSNP:78191244
256 256 g, t dbSNP:201584846
303 303 a, t dbSNP:200340671
320 320 c, g dbSNP:202039131
327 327 c, g dbSNP:200883456
335 335 a, g dbSNP:200117700
341 341 c, t dbSNP:201677979
349 349 g, t dbSNP:552183289
413 413 a, c dbSNP:35025994
428 428 c, t dbSNP:200773845
429 429 c, t dbSNP:199974871
430 430 a, g dbSNP:11551226
439 439 a, t dbSNP:202033907
464 464 c, t dbSNP:200915629
496 496 c, t dbSNP:11466316
523 523 c, t dbSNP:201696222
540 540 a, c dbSNP:200716568
555 555 c, t dbSNP:45457101
559 559 c, g dbSNP:201530894
571 571 a, c dbSNP:200538848
607 607 a, c dbSNP:13306706
608 608 a, c, g dbSNP:201704451
623 623 a, c dbSNP:147066206
625 625 a, g dbSNP:200500159
634 634 a, c, g dbSNP:13306707
635 635 c, t dbSNP:141633455
647 647 c, g dbSNP:45616242
654 654 c, g dbSNP:61761350
670 670 c, t dbSNP:201093139
712 712 -, c dbSNP:281865481
715 715 a, t dbSNP:375306535
727 727 c, t dbSNP:200273952
741 741 c, t dbSNP:13306708
744 744 c, t dbSNP:573467500
759 759 a, c dbSNP:201020311
764 764 -, ccc dbSNP:200016578
769 769 c, t dbSNP:36102838
792 792 c, g dbSNP:199968369
807 807 c, t dbSNP:201994282
810 810 a, g dbSNP:56155294
816 816 a, g dbSNP:757563676
817 817 c, t dbSNP:149770409
838 838 a, c, g dbSNP:140027851
847 847 a, g dbSNP:200135233
849 849 g, t dbSNP:151118561
855 855 c, g dbSNP:201619377
863 863 c, g dbSNP:756013122
868 868 a, g dbSNP:539690559
869 869 -, g dbSNP:749452831
869 869 a, g dbSNP:9282871
872 872 c, t dbSNP:199947003
882 882 c, g dbSNP:755689139
893 893 c, t dbSNP:752190020
894 894 c, g dbSNP:201834171
895 895 a, c, g dbSNP:759113717
901 901 c, t dbSNP:774013338
902 902 g, t dbSNP:765539991
903 903 c, g dbSNP:762213228
911 911 -, cgctgc dbSNP:755927938
911 911 -, cgc dbSNP:779901179
911 911 -, t dbSNP:201844761
911 911 c, g, t dbSNP:1800470
912 912 a, g dbSNP:747464480
920 920 -, gctgctgct dbSNP:281865483
925 925 c, t dbSNP:775720479
937 937 c, t dbSNP:72480425
940 940 c, g dbSNP:746102616
944 944 c, t dbSNP:779175884
954 954 a, c dbSNP:146353438
956 956 c, g dbSNP:1800471
963 963 c, g dbSNP:777746049
966 966 a, g dbSNP:527542249
967 967 a, g dbSNP:200868154
968 968 a, c, g dbSNP:66551611
968 968 a, c, g dbSNP:199758510
973 973 g, t dbSNP:61761349
978 978 a, c dbSNP:139854151
990 990 c, g dbSNP:551552217
994 994 a, g dbSNP:751217033
995 995 c, t dbSNP:758523150
1012 1012 a, c dbSNP:766021098
1022 1022 a, g dbSNP:13447341
1025 1025 c, g dbSNP:762331262
1040 1040 c, t dbSNP:777118195
1041 1041 c, t dbSNP:764491141
1057 1057 a, c dbSNP:145953838
1060 1060 c, g dbSNP:201283333
1071 1071 -, g dbSNP:750211892
1073 1073 c, g dbSNP:533204331
1080 1080 a, g dbSNP:772095480
1088 1088 c, t dbSNP:745931726
1093 1093 a, g dbSNP:200230522
1097 1097 a, c dbSNP:774505337
1104 1104 c, t dbSNP:149455461
1110 1110 c, t dbSNP:771172130
1122 1122 a, g dbSNP:199592796
1123 1123 c, t dbSNP:111033611
1130 1130 c, g dbSNP:777547933
1134 1134 a, c, t dbSNP:199704558
1137 1137 c, t dbSNP:748104908
1138 1138 g, t dbSNP:201155269
1140 1140 c, t dbSNP:754483500
1142 1142 c, g dbSNP:751073303
1148 1148 c, t dbSNP:371589941
1167 1167 c, g dbSNP:758132393
1168 1168 a, g dbSNP:200512008
1173 1173 c, t dbSNP:147873920
1174 1174 a, g dbSNP:761100949
1177 1177 a, c dbSNP:753186435
1182 1182 a, g, t dbSNP:137864931
1188 1188 c, g dbSNP:759592536
1203 1203 a, g dbSNP:774502862
1215 1215 a, g dbSNP:529422438
1219 1219 a, g dbSNP:763192902
1220 1220 c, t dbSNP:562072561
1230 1230 c, t dbSNP:56281462
1251 1251 g, t dbSNP:766838405
1254 1254 c, t dbSNP:201417808
1256 1256 a, g dbSNP:750486222
1274 1274 c, t dbSNP:200652346
1277 1277 a, g dbSNP:200481365
1278 1278 c, t dbSNP:199696548
1281 1281 a, g dbSNP:201567874
1288 1288 a, t dbSNP:764002407
1290 1290 c, t dbSNP:760358819
1293 1293 a, t dbSNP:202071274
1302 1302 c, t dbSNP:772123190
1304 1304 a, g dbSNP:745744175
1310 1310 c, t dbSNP:774002594
1317 1317 g, t dbSNP:770307128
1323 1323 c, g, t dbSNP:200674778
1324 1324 a, g, t dbSNP:142642007
1325 1325 c, t dbSNP:747327039
1334 1334 c, t dbSNP:374698583
1336 1336 c, t dbSNP:201405597
1337 1337 a, g, t dbSNP:765327656
1338 1338 a, g dbSNP:757266734
1348 1348 c, t dbSNP:200482214
1356 1356 a, g dbSNP:767098791
1383 1383 c, t dbSNP:764220658
1387 1387 a, c, g dbSNP:281865484
1392 1392 a, g dbSNP:199678149
1395 1395 c, t dbSNP:775440657
1405 1405 a, g dbSNP:747738656
1409 1409 a, g dbSNP:780397214
1411 1411 a, g dbSNP:202057576
1416 1416 c, t dbSNP:772383040
1421 1421 a, g dbSNP:201951718
1425 1425 c, t dbSNP:779260857
1426 1426 c, g, t dbSNP:753852676
1433 1433 a, g dbSNP:777853244
1435 1435 a, c, t dbSNP:201055697
1436 1436 a, g dbSNP:200030349
1438 1438 c, t dbSNP:140746279
1441 1441 c, t dbSNP:759382690
1447 1447 c, t dbSNP:201828175
1452 1452 c, g, t dbSNP:779809888
1453 1453 a, g dbSNP:201383660
1458 1458 a, g dbSNP:766221068
1470 1470 a, c dbSNP:762579148
1480 1480 a, g dbSNP:539765936
1485 1485 c, t dbSNP:772607764
1486 1486 a, g dbSNP:151105395
1489 1489 a, g dbSNP:142931834
1495 1495 c, t dbSNP:199882566
1496 1496 a, g dbSNP:772469907
1505 1505 g, t dbSNP:146875339
1507 1507 a, c dbSNP:746228911
1510 1510 c, t dbSNP:779534698
1511 1511 a, g dbSNP:201430293
1516 1516 a, g dbSNP:200611791
1518 1518 a, g dbSNP:761285322
1524 1524 a, t dbSNP:373381454
1531 1531 c, t dbSNP:141352462
1534 1534 c, t dbSNP:104894721
1535 1535 a, g dbSNP:104894720
1542 1542 c, t dbSNP:760937418
1543 1543 a, g, t dbSNP:201327622
1546 1546 c, g dbSNP:281865485
1548 1548 c, t dbSNP:200351572
1549 1549 a, c, g, t dbSNP:104894722
1555 1555 c, t dbSNP:104894719
1558 1558 a, g dbSNP:202088345
1562 1562 a, g dbSNP:201772874
1564 1564 a, g dbSNP:760265490
1565 1565 a, g dbSNP:774585135
1566 1566 a, g dbSNP:771288773
1568 1568 a, g dbSNP:749782632
1572 1572 c, g dbSNP:773748442
1576 1576 c, t dbSNP:200317548
1579 1579 c, t dbSNP:770033162
1584 1584 a, g dbSNP:202184772
1593 1593 c, t dbSNP:748234689
1595 1595 c, g dbSNP:530534755
1596 1596 a, c, t dbSNP:112108984
1600 1600 a, t dbSNP:569594975
1603 1603 a, c, g dbSNP:148552731
1606 1606 a, g dbSNP:747216224
1607 1607 c, t dbSNP:72480424
1608 1608 a, c, t dbSNP:35383147
1609 1609 a, g dbSNP:745664232
1614 1614 c, g dbSNP:546927712
1616 1616 -, t dbSNP:34233206
1633 1633 a, g dbSNP:778626011
1634 1634 g, t dbSNP:757193903
1648 1648 c, t dbSNP:753735387
1649 1649 a, g dbSNP:149900977
1665 1665 c, t dbSNP:755630382
1666 1666 a, t dbSNP:547881966
1670 1670 c, t dbSNP:767192967
1673 1673 c, t dbSNP:1800472
1676 1676 c, t dbSNP:146182311
1677 1677 a, g dbSNP:200558128
1683 1683 a, g dbSNP:267605501
1686 1686 a, g dbSNP:373586759
1693 1693 c, t dbSNP:201948484
1703 1703 a, g dbSNP:559265663
1704 1704 c, t dbSNP:141484614
1706 1706 c, t dbSNP:775636009
1716 1716 c, g dbSNP:201119217
1719 1719 a, g dbSNP:746014542
1724 1724 c, t dbSNP:778711968
1731 1731 c, g dbSNP:770664280
1736 1736 a, g dbSNP:749275172
1751 1751 c, t dbSNP:770754343
1752 1752 a, c, g, t dbSNP:769782160
1757 1757 a, c dbSNP:747968669
1758 1758 -, gaa dbSNP:774427089
1758 1758 a, g dbSNP:190566789
1772 1772 a, g dbSNP:200164212
1777 1777 c, t dbSNP:139977837
1779 1779 a, g dbSNP:779818818
1784 1784 c, t dbSNP:201635147
1792 1792 c, t dbSNP:200527282
1793 1793 a, g dbSNP:775861573
1801 1801 c, t dbSNP:199946261
1803 1803 c, t dbSNP:72480429
1807 1807 c, t dbSNP:761279576
1811 1811 a, g dbSNP:369182751
1821 1821 c, g, t dbSNP:767685429
1824 1824 g, t dbSNP:200763912
1827 1827 c, t dbSNP:759582721
1829 1829 a, g dbSNP:199516461
1830 1830 c, g dbSNP:766572720
1838 1838 a, g dbSNP:763101036
1842 1842 c, g dbSNP:201366321
1846 1846 c, t dbSNP:769434404
1848 1848 c, t dbSNP:11551225
1852 1852 c, t dbSNP:748135261
1854 1854 c, t dbSNP:776406237
1855 1855 a, g dbSNP:768250306
1857 1857 a, g dbSNP:11466358
1858 1858 c, g dbSNP:200209614
1863 1863 c, t dbSNP:758130535
1864 1864 a, c dbSNP:56361919
1876 1876 a, g dbSNP:745482429
1877 1877 a, c, g dbSNP:199713772
1878 1878 c, t dbSNP:201281623
1882 1882 a, g dbSNP:200230083
1886 1886 c, t dbSNP:753287325
1895 1895 a, c, g dbSNP:199699574
1924 1924 a, t dbSNP:763943753
1932 1932 a, c dbSNP:368054278
1936 1936 -, tcg dbSNP:780197769
1940 1940 c, t dbSNP:775550741
1941 1941 c, g dbSNP:771748887
1947 1947 a, g dbSNP:373910726
1955 1955 g, t dbSNP:199849225
1967 1967 g, t dbSNP:541829714
1973 1973 c, g dbSNP:758966134
1989 1989 c, t dbSNP:370517732
1999 1999 c, t dbSNP:770505137
2019 2019 a, g dbSNP:748901865
2027 2027 a, c dbSNP:781566009
2034 2034 c, t dbSNP:768959025
2035 2035 g, t dbSNP:747563417
2037 2037 a, g dbSNP:780503471
2039 2039 a, g dbSNP:201700967
2040 2040 c, t dbSNP:550662946
2067 2067 -, gcgcc dbSNP:770027604
2076 2076 -, ccccgccccg dbSNP:757277969
2081 2081 -, ccccg dbSNP:780991744
2085 2085 -, ccccg dbSNP:745683754
2151 2151 c, t dbSNP:201096069
2156 2156 a, c dbSNP:200179008
2164 2164 c, g dbSNP:201889805
2187 2187 a, g dbSNP:200729745
2194 2194 a, g dbSNP:199636275
2195 2195 g, t dbSNP:201564160

Target ORF information:

RefSeq Version XM_011527242
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens transforming growth factor, beta 1 (TGFB1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011527242

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGCAGGGTTC
ACTACCGGCC GCCGAGGTGA CCTGGCCACC ATTCATGGCA TGAACCGGCC TTTCCTGCTT
CTCATGGCCA CCCCGCTGGA GAGGGCCCAG CATCTGCAAA GCTCCCGGCA CCGCCGAGCC
CTGGACACCA ACTATTGCTT CAGCTCCACG GAGAAGAACT GCTGCGTGCG GCAGCTGTAC
ATTGACTTCC GCAAGGACCT CGGCTGGAAG TGGATCCACG AGCCCAAGGG CTACCATGCC
AACTTCTGCC TCGGGCCCTG CCCCTACATT TGGAGCCTGG ACACGCAGTA CAGCAAGGTC
CTGGCCCTGT ACAACCAGCA TAACCCGGGC GCCTCGGCGG CGCCGTGCTG CGTGCCGCAG
GCGCTGGAGC CGCTGCCCAT CGTGTACTAC GTGGGCCGCA AGCCCAAGGT GGAGCAGCTG
TCCAACATGA TCGTGCGCTC CTGCAAGTGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27680
Accession Version NM_000660.5
Sequence Information ORF Nucleotide Sequence (Length: 1173bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transforming growth factor beta-1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG115704.1, X02812.1 and BC000125.1. This sequence is a reference standard in the RefSeqGene project. On Oct 23, 2013 this sequence version replaced gi:260655621. Summary: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02812.1, BC000125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGGGTTCACT
ACCGGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGGCCTTT CCTGCTTCTC
ATGGCCACCC CGCTGGAGAG GGCCCAGCAT CTGCAAAGCT CCCGGCACCG CCGAGCCCTG
GACACCAACT ATTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTGCGGCA GCTGTACATT
GACTTCCGCA AGGACCTCGG CTGGAAGTGG ATCCACGAGC CCAAGGGCTA CCATGCCAAC
TTCTGCCTCG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG
GCCCTGTACA ACCAGCATAA CCCGGGCGCC TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG
CTGGAGCCGC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCC
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000651.3
CDS890..2062
Misc Feature(1)51..51(+)
Misc Feature(2)134..136(+)
Misc Feature(3)321..321(+)
Misc Feature(4)971..1672(+)
Misc Feature(5)977..1111(+)
Misc Feature(6)1112..1702(+)
Misc Feature(7)1619..1627(+)
Misc Feature(8)1757..2059(+)
Exon (1)1..1244
Gene:TGFB1
Gene Synonym:
Exon (2)1245..1405
Gene:TGFB1
Gene Synonym:
Exon (3)1406..1523
Gene:TGFB1
Gene Synonym:
Exon (4)1524..1601
Gene:TGFB1
Gene Synonym:
Exon (5)1602..1749
Gene:TGFB1
Gene Synonym:
Exon (6)1750..1903
Gene:TGFB1
Gene Synonym:
Exon (7)1904..2583
Gene:TGFB1
Gene Synonym:
Translation
Position Chain Variation Link
33 33 a, c dbSNP:12977628
53 53 a, c dbSNP:527614232
56 56 c, t dbSNP:560261580
57 57 c, t dbSNP:12977601
58 58 a, t dbSNP:12985978
63 63 c, g dbSNP:11466315
107 107 a, g dbSNP:778503498
112 112 a, g dbSNP:36185305
121 121 -, c dbSNP:1800999
128 128 -, c dbSNP:1799753
145 145 c, t dbSNP:200356936
208 208 c, t dbSNP:202216587
242 242 c, g dbSNP:11551223
248 248 a, g dbSNP:79132525
249 249 a, g dbSNP:78191244
263 263 g, t dbSNP:201584846
310 310 a, t dbSNP:200340671
327 327 c, g dbSNP:202039131
334 334 c, g dbSNP:200883456
342 342 a, g dbSNP:200117700
348 348 c, t dbSNP:201677979
356 356 g, t dbSNP:552183289
420 420 a, c dbSNP:35025994
435 435 c, t dbSNP:200773845
436 436 c, t dbSNP:199974871
437 437 a, g dbSNP:11551226
446 446 a, t dbSNP:202033907
471 471 c, t dbSNP:200915629
503 503 c, t dbSNP:11466316
530 530 c, t dbSNP:201696222
547 547 a, c dbSNP:200716568
562 562 c, t dbSNP:45457101
566 566 c, g dbSNP:201530894
578 578 a, c dbSNP:200538848
614 614 a, c dbSNP:13306706
615 615 a, c, g dbSNP:201704451
630 630 a, c dbSNP:147066206
632 632 a, g dbSNP:200500159
641 641 a, c, g dbSNP:13306707
642 642 c, t dbSNP:141633455
654 654 c, g dbSNP:45616242
661 661 c, g dbSNP:61761350
677 677 c, t dbSNP:201093139
719 719 -, c dbSNP:281865481
722 722 a, t dbSNP:375306535
734 734 c, t dbSNP:200273952
748 748 c, t dbSNP:13306708
751 751 c, t dbSNP:573467500
766 766 a, c dbSNP:201020311
771 771 -, ccc dbSNP:200016578
776 776 c, t dbSNP:36102838
799 799 c, g dbSNP:199968369
814 814 c, t dbSNP:201994282
817 817 a, g dbSNP:56155294
823 823 a, g dbSNP:757563676
824 824 c, t dbSNP:149770409
845 845 a, c, g dbSNP:140027851
854 854 a, g dbSNP:200135233
856 856 g, t dbSNP:151118561
862 862 c, g dbSNP:201619377
870 870 c, g dbSNP:756013122
875 875 a, g dbSNP:539690559
876 876 -, g dbSNP:749452831
876 876 a, g dbSNP:9282871
879 879 c, t dbSNP:199947003
889 889 c, g dbSNP:755689139
900 900 c, t dbSNP:752190020
901 901 c, g dbSNP:201834171
902 902 a, c, g dbSNP:759113717
908 908 c, t dbSNP:774013338
909 909 g, t dbSNP:765539991
910 910 c, g dbSNP:762213228
918 918 -, cgctgc dbSNP:755927938
918 918 -, cgc dbSNP:779901179
918 918 -, t dbSNP:201844761
918 918 c, g, t dbSNP:1800470
919 919 a, g dbSNP:747464480
927 927 -, gctgctgct dbSNP:281865483
932 932 c, t dbSNP:775720479
944 944 c, t dbSNP:72480425
947 947 c, g dbSNP:746102616
951 951 c, t dbSNP:779175884
961 961 a, c dbSNP:146353438
963 963 c, g dbSNP:1800471
970 970 c, g dbSNP:777746049
973 973 a, g dbSNP:527542249
974 974 a, g dbSNP:200868154
975 975 a, c, g dbSNP:66551611
975 975 a, c, g dbSNP:199758510
980 980 g, t dbSNP:61761349
985 985 a, c dbSNP:139854151
997 997 c, g dbSNP:551552217
1001 1001 a, g dbSNP:751217033
1002 1002 c, t dbSNP:758523150
1019 1019 a, c dbSNP:766021098
1029 1029 a, g dbSNP:13447341
1032 1032 c, g dbSNP:762331262
1047 1047 c, t dbSNP:777118195
1048 1048 c, t dbSNP:764491141
1064 1064 a, c dbSNP:145953838
1067 1067 c, g dbSNP:201283333
1078 1078 -, g dbSNP:750211892
1080 1080 c, g dbSNP:533204331
1087 1087 a, g dbSNP:772095480
1095 1095 c, t dbSNP:745931726
1100 1100 a, g dbSNP:200230522
1104 1104 a, c dbSNP:774505337
1111 1111 c, t dbSNP:149455461
1117 1117 c, t dbSNP:771172130
1129 1129 a, g dbSNP:199592796
1130 1130 c, t dbSNP:111033611
1137 1137 c, g dbSNP:777547933
1141 1141 a, c, t dbSNP:199704558
1144 1144 c, t dbSNP:748104908
1145 1145 g, t dbSNP:201155269
1147 1147 c, t dbSNP:754483500
1149 1149 c, g dbSNP:751073303
1155 1155 c, t dbSNP:371589941
1174 1174 c, g dbSNP:758132393
1175 1175 a, g dbSNP:200512008
1180 1180 c, t dbSNP:147873920
1181 1181 a, g dbSNP:761100949
1184 1184 a, c dbSNP:753186435
1189 1189 a, g, t dbSNP:137864931
1195 1195 c, g dbSNP:759592536
1210 1210 a, g dbSNP:774502862
1222 1222 a, g dbSNP:529422438
1226 1226 a, g dbSNP:763192902
1227 1227 c, t dbSNP:562072561
1237 1237 c, t dbSNP:56281462
1258 1258 g, t dbSNP:766838405
1261 1261 c, t dbSNP:201417808
1263 1263 a, g dbSNP:750486222
1281 1281 c, t dbSNP:200652346
1284 1284 a, g dbSNP:200481365
1285 1285 c, t dbSNP:199696548
1288 1288 a, g dbSNP:201567874
1295 1295 a, t dbSNP:764002407
1297 1297 c, t dbSNP:760358819
1300 1300 a, t dbSNP:202071274
1309 1309 c, t dbSNP:772123190
1311 1311 a, g dbSNP:745744175
1317 1317 c, t dbSNP:774002594
1324 1324 g, t dbSNP:770307128
1330 1330 c, g, t dbSNP:200674778
1331 1331 a, g, t dbSNP:142642007
1332 1332 c, t dbSNP:747327039
1341 1341 c, t dbSNP:374698583
1343 1343 c, t dbSNP:201405597
1344 1344 a, g, t dbSNP:765327656
1345 1345 a, g dbSNP:757266734
1355 1355 c, t dbSNP:200482214
1363 1363 a, g dbSNP:767098791
1390 1390 c, t dbSNP:764220658
1394 1394 a, c, g dbSNP:281865484
1399 1399 a, g dbSNP:199678149
1402 1402 c, t dbSNP:775440657
1412 1412 a, g dbSNP:747738656
1416 1416 a, g dbSNP:780397214
1418 1418 a, g dbSNP:202057576
1423 1423 c, t dbSNP:772383040
1428 1428 a, g dbSNP:201951718
1432 1432 c, t dbSNP:779260857
1433 1433 c, g, t dbSNP:753852676
1440 1440 a, g dbSNP:777853244
1442 1442 a, c, t dbSNP:201055697
1443 1443 a, g dbSNP:200030349
1445 1445 c, t dbSNP:140746279
1448 1448 c, t dbSNP:759382690
1454 1454 c, t dbSNP:201828175
1459 1459 c, g, t dbSNP:779809888
1460 1460 a, g dbSNP:201383660
1465 1465 a, g dbSNP:766221068
1477 1477 a, c dbSNP:762579148
1487 1487 a, g dbSNP:539765936
1492 1492 c, t dbSNP:772607764
1493 1493 a, g dbSNP:151105395
1496 1496 a, g dbSNP:142931834
1502 1502 c, t dbSNP:199882566
1503 1503 a, g dbSNP:772469907
1512 1512 g, t dbSNP:146875339
1514 1514 a, c dbSNP:746228911
1517 1517 c, t dbSNP:779534698
1518 1518 a, g dbSNP:201430293
1523 1523 a, g dbSNP:200611791
1525 1525 a, g dbSNP:761285322
1531 1531 a, t dbSNP:373381454
1538 1538 c, t dbSNP:141352462
1541 1541 c, t dbSNP:104894721
1542 1542 a, g dbSNP:104894720
1549 1549 c, t dbSNP:760937418
1550 1550 a, g, t dbSNP:201327622
1553 1553 c, g dbSNP:281865485
1555 1555 c, t dbSNP:200351572
1556 1556 a, c, g, t dbSNP:104894722
1562 1562 c, t dbSNP:104894719
1565 1565 a, g dbSNP:202088345
1569 1569 a, g dbSNP:201772874
1571 1571 a, g dbSNP:760265490
1572 1572 a, g dbSNP:774585135
1573 1573 a, g dbSNP:771288773
1575 1575 a, g dbSNP:749782632
1579 1579 c, g dbSNP:773748442
1583 1583 c, t dbSNP:200317548
1586 1586 c, t dbSNP:770033162
1591 1591 a, g dbSNP:202184772
1600 1600 c, t dbSNP:748234689
1604 1604 a, t dbSNP:569594975
1607 1607 a, c, g dbSNP:148552731
1610 1610 a, g dbSNP:747216224
1611 1611 c, t dbSNP:72480424
1612 1612 a, c, t dbSNP:35383147
1613 1613 a, g dbSNP:745664232
1618 1618 c, g dbSNP:546927712
1620 1620 -, t dbSNP:34233206
1637 1637 a, g dbSNP:778626011
1638 1638 g, t dbSNP:757193903
1652 1652 c, t dbSNP:753735387
1653 1653 a, g dbSNP:149900977
1669 1669 c, t dbSNP:755630382
1670 1670 a, t dbSNP:547881966
1674 1674 c, t dbSNP:767192967
1677 1677 c, t dbSNP:1800472
1680 1680 c, t dbSNP:146182311
1681 1681 a, g dbSNP:200558128
1687 1687 a, g dbSNP:267605501
1690 1690 a, g dbSNP:373586759
1697 1697 c, t dbSNP:201948484
1707 1707 a, g dbSNP:559265663
1708 1708 c, t dbSNP:141484614
1710 1710 c, t dbSNP:775636009
1720 1720 c, g dbSNP:201119217
1723 1723 a, g dbSNP:746014542
1728 1728 c, t dbSNP:778711968
1735 1735 c, g dbSNP:770664280
1740 1740 a, g dbSNP:749275172
1755 1755 c, t dbSNP:770754343
1756 1756 a, c, g, t dbSNP:769782160
1761 1761 a, c dbSNP:747968669
1762 1762 -, gaa dbSNP:774427089
1762 1762 a, g dbSNP:190566789
1776 1776 a, g dbSNP:200164212
1781 1781 c, t dbSNP:139977837
1783 1783 a, g dbSNP:779818818
1788 1788 c, t dbSNP:201635147
1796 1796 c, t dbSNP:200527282
1797 1797 a, g dbSNP:775861573
1805 1805 c, t dbSNP:199946261
1807 1807 c, t dbSNP:72480429
1811 1811 c, t dbSNP:761279576
1815 1815 a, g dbSNP:369182751
1825 1825 c, g, t dbSNP:767685429
1828 1828 g, t dbSNP:200763912
1831 1831 c, t dbSNP:759582721
1833 1833 a, g dbSNP:199516461
1834 1834 c, g dbSNP:766572720
1842 1842 a, g dbSNP:763101036
1846 1846 c, g dbSNP:201366321
1850 1850 c, t dbSNP:769434404
1852 1852 c, t dbSNP:11551225
1856 1856 c, t dbSNP:748135261
1858 1858 c, t dbSNP:776406237
1859 1859 a, g dbSNP:768250306
1861 1861 a, g dbSNP:11466358
1862 1862 c, g dbSNP:200209614
1867 1867 c, t dbSNP:758130535
1868 1868 a, c dbSNP:56361919
1880 1880 a, g dbSNP:745482429
1881 1881 a, c, g dbSNP:199713772
1882 1882 c, t dbSNP:201281623
1886 1886 a, g dbSNP:200230083
1890 1890 c, t dbSNP:753287325
1899 1899 a, c, g dbSNP:199699574
1928 1928 a, t dbSNP:763943753
1936 1936 a, c dbSNP:368054278
1940 1940 -, tcg dbSNP:780197769
1944 1944 c, t dbSNP:775550741
1945 1945 c, g dbSNP:771748887
1951 1951 a, g dbSNP:373910726
1959 1959 g, t dbSNP:199849225
1971 1971 g, t dbSNP:541829714
1977 1977 c, g dbSNP:758966134
1993 1993 c, t dbSNP:370517732
2003 2003 c, t dbSNP:770505137
2023 2023 a, g dbSNP:748901865
2031 2031 a, c dbSNP:781566009
2038 2038 c, t dbSNP:768959025
2039 2039 g, t dbSNP:747563417
2041 2041 a, g dbSNP:780503471
2043 2043 a, g dbSNP:201700967
2044 2044 c, t dbSNP:550662946
2071 2071 -, gcgcc dbSNP:770027604
2080 2080 -, ccccgccccg dbSNP:757277969
2085 2085 -, ccccg dbSNP:780991744
2089 2089 -, ccccg dbSNP:745683754
2155 2155 c, t dbSNP:201096069
2160 2160 a, c dbSNP:200179008
2168 2168 c, g dbSNP:201889805
2191 2191 a, g dbSNP:200729745
2198 2198 a, g dbSNP:199636275
2199 2199 g, t dbSNP:201564160
2229 2229 g, t dbSNP:529010133
2234 2234 c, g dbSNP:200673279
2242 2242 a, g dbSNP:199517779
2258 2258 c, g, t dbSNP:201103297
2264 2264 c, g dbSNP:200451143
2276 2276 c, t dbSNP:199704340
2278 2278 c, t dbSNP:201584524
2284 2284 c, g dbSNP:200340652
2302 2302 a, c dbSNP:202014722
2321 2321 a, g dbSNP:201075248
2327 2327 a, g dbSNP:145297814
2357 2357 c, t dbSNP:201969193
2389 2389 c, t dbSNP:201098768
2394 2394 c, t dbSNP:199972613
2403 2403 c, g dbSNP:780713127
2407 2407 c, t dbSNP:202033577
2432 2432 c, t dbSNP:528369770
2468 2468 a, c dbSNP:759721166
2479 2479 a, g dbSNP:776754317
2539 2539 a, g dbSNP:770979365
2551 2551 g, t dbSNP:565441012

Target ORF information:

RefSeq Version NM_000660
Organism Homo sapiens (human)
Definition Homo sapiens transforming growth factor, beta 1 (TGFB1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000660

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGGGTTCACT
ACCGGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGGCCTTT CCTGCTTCTC
ATGGCCACCC CGCTGGAGAG GGCCCAGCAT CTGCAAAGCT CCCGGCACCG CCGAGCCCTG
GACACCAACT ATTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTGCGGCA GCTGTACATT
GACTTCCGCA AGGACCTCGG CTGGAAGTGG ATCCACGAGC CCAAGGGCTA CCATGCCAAC
TTCTGCCTCG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG
GCCCTGTACA ACCAGCATAA CCCGGGCGCC TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG
CTGGAGCCGC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCC
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.