×

TGFB1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TGFB1
Entrez Gene ID 7040
Full Name transforming growth factor, beta 1
Synonyms CED, DPD1, LAP, TGFB, TGFbeta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.1

Summary This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

190180

Disorder Html: Camurati-Engelmann disease, 131300 (3); {Cystic fibrosis lung

mRNA and Protein(s)

mRNA Protein Name
XM_011527242 XP_011525544 transforming growth factor beta-1 isoform X1
NM_000660 NP_000651 transforming growth factor beta-1 precursor



Homo sapiens (human) TGFB1 NP_000651.3
Pan troglodytes (chimpanzee) TGFB1 XP_512687.2
Canis lupus familiaris (dog) TGFB1 NP_001003309.1
Bos taurus (cattle) TGFB1 NP_001159540.1
Mus musculus (house mouse) Tgfb1 NP_035707.1
Rattus norvegicus (Norway rat) Tgfb1 NP_067589.1
Danio rerio (zebrafish) LOC563884 XP_692338.3
Danio rerio (zebrafish) tgfb1a NP_878293.1
Xenopus (Silurana) tropicalis (western clawed frog) tgfb1 XP_002939433.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TGFB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGFB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu60972 XM_011527242 PREDICTED: Homo sapiens transforming growth factor, beta 1 (TGFB1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
OHu27680
NM_000660 Homo sapiens transforming growth factor, beta 1 (TGFB1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu60972
Clone ID Related Accession (Same CDS sequence) XM_011527242
Accession Version XM_011527242.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1176bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transforming growth factor beta-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011109.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGCAGGGTTC
ACTACCGGCC GCCGAGGTGA CCTGGCCACC ATTCATGGCA TGAACCGGCC TTTCCTGCTT
CTCATGGCCA CCCCGCTGGA GAGGGCCCAG CATCTGCAAA GCTCCCGGCA CCGCCGAGCC
CTGGACACCA ACTATTGCTT CAGCTCCACG GAGAAGAACT GCTGCGTGCG GCAGCTGTAC
ATTGACTTCC GCAAGGACCT CGGCTGGAAG TGGATCCACG AGCCCAAGGG CTACCATGCC
AACTTCTGCC TCGGGCCCTG CCCCTACATT TGGAGCCTGG ACACGCAGTA CAGCAAGGTC
CTGGCCCTGT ACAACCAGCA TAACCCGGGC GCCTCGGCGG CGCCGTGCTG CGTGCCGCAG
GCGCTGGAGC CGCTGCCCAT CGTGTACTAC GTGGGCCGCA AGCCCAAGGT GGAGCAGCTG
TCCAACATGA TCGTGCGCTC CTGCAAGTGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011525544.1
CDS883..2058
Misc Feature(1)964..1668(+)
Misc Feature(2)1753..2055(+)
Translation

Target ORF information:

RefSeq Version XM_011527242
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens transforming growth factor, beta 1 (TGFB1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011527242

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGCAGGGTTC
ACTACCGGCC GCCGAGGTGA CCTGGCCACC ATTCATGGCA TGAACCGGCC TTTCCTGCTT
CTCATGGCCA CCCCGCTGGA GAGGGCCCAG CATCTGCAAA GCTCCCGGCA CCGCCGAGCC
CTGGACACCA ACTATTGCTT CAGCTCCACG GAGAAGAACT GCTGCGTGCG GCAGCTGTAC
ATTGACTTCC GCAAGGACCT CGGCTGGAAG TGGATCCACG AGCCCAAGGG CTACCATGCC
AACTTCTGCC TCGGGCCCTG CCCCTACATT TGGAGCCTGG ACACGCAGTA CAGCAAGGTC
CTGGCCCTGT ACAACCAGCA TAACCCGGGC GCCTCGGCGG CGCCGTGCTG CGTGCCGCAG
GCGCTGGAGC CGCTGCCCAT CGTGTACTAC GTGGGCCGCA AGCCCAAGGT GGAGCAGCTG
TCCAACATGA TCGTGCGCTC CTGCAAGTGC AGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27680
Clone ID Related Accession (Same CDS sequence) NM_000660
Accession Version NM_000660.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1173bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transforming growth factor beta-1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG115704.1, X02812.1 and BC000125.1. This sequence is a reference standard in the RefSeqGene project. On Oct 23, 2013 this sequence version replaced gi:260655621. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02812.1, BC000125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2142670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGGGTTCACT
ACCGGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGGCCTTT CCTGCTTCTC
ATGGCCACCC CGCTGGAGAG GGCCCAGCAT CTGCAAAGCT CCCGGCACCG CCGAGCCCTG
GACACCAACT ATTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTGCGGCA GCTGTACATT
GACTTCCGCA AGGACCTCGG CTGGAAGTGG ATCCACGAGC CCAAGGGCTA CCATGCCAAC
TTCTGCCTCG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG
GCCCTGTACA ACCAGCATAA CCCGGGCGCC TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG
CTGGAGCCGC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCC
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000651.3
CDS890..2062
Misc Feature(1)51..51(+)
Misc Feature(2)134..136(+)
Misc Feature(3)321..321(+)
Misc Feature(4)971..1672(+)
Misc Feature(5)977..1111(+)
Misc Feature(6)1112..1702(+)
Misc Feature(7)1619..1627(+)
Misc Feature(8)1757..2059(+)
Exon (1)1..1244
Gene:TGFB1
Gene Synonym:
Exon (2)1245..1405
Gene:TGFB1
Gene Synonym:
Exon (3)1406..1523
Gene:TGFB1
Gene Synonym:
Exon (4)1524..1601
Gene:TGFB1
Gene Synonym:
Exon (5)1602..1749
Gene:TGFB1
Gene Synonym:
Exon (6)1750..1903
Gene:TGFB1
Gene Synonym:
Exon (7)1904..2583
Gene:TGFB1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000660
Organism Homo sapiens (human)
Definition Homo sapiens transforming growth factor, beta 1 (TGFB1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000660

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCGCCCT CCGGGCTGCG GCTGCTGCCG CTGCTGCTAC CGCTGCTGTG GCTACTGGTG 
CTGACGCCTG GCCGGCCGGC CGCGGGACTA TCCACCTGCA AGACTATCGA CATGGAGCTG
GTGAAGCGGA AGCGCATCGA GGCCATCCGC GGCCAGATCC TGTCCAAGCT GCGGCTCGCC
AGCCCCCCGA GCCAGGGGGA GGTGCCGCCC GGCCCGCTGC CCGAGGCCGT GCTCGCCCTG
TACAACAGCA CCCGCGACCG GGTGGCCGGG GAGAGTGCAG AACCGGAGCC CGAGCCTGAG
GCCGACTACT ACGCCAAGGA GGTCACCCGC GTGCTAATGG TGGAAACCCA CAACGAAATC
TATGACAAGT TCAAGCAGAG TACACACAGC ATATATATGT TCTTCAACAC ATCAGAGCTC
CGAGAAGCGG TACCTGAACC CGTGTTGCTC TCCCGGGCAG AGCTGCGTCT GCTGAGGCTC
AAGTTAAAAG TGGAGCAGCA CGTGGAGCTG TACCAGAAAT ACAGCAACAA TTCCTGGCGA
TACCTCAGCA ACCGGCTGCT GGCACCCAGC GACTCGCCAG AGTGGTTATC TTTTGATGTC
ACCGGAGTTG TGCGGCAGTG GTTGAGCCGT GGAGGGGAAA TTGAGGGCTT TCGCCTTAGC
GCCCACTGCT CCTGTGACAG CAGGGATAAC ACACTGCAAG TGGACATCAA CGGGTTCACT
ACCGGCCGCC GAGGTGACCT GGCCACCATT CATGGCATGA ACCGGCCTTT CCTGCTTCTC
ATGGCCACCC CGCTGGAGAG GGCCCAGCAT CTGCAAAGCT CCCGGCACCG CCGAGCCCTG
GACACCAACT ATTGCTTCAG CTCCACGGAG AAGAACTGCT GCGTGCGGCA GCTGTACATT
GACTTCCGCA AGGACCTCGG CTGGAAGTGG ATCCACGAGC CCAAGGGCTA CCATGCCAAC
TTCTGCCTCG GGCCCTGCCC CTACATTTGG AGCCTGGACA CGCAGTACAG CAAGGTCCTG
GCCCTGTACA ACCAGCATAA CCCGGGCGCC TCGGCGGCGC CGTGCTGCGT GCCGCAGGCG
CTGGAGCCGC TGCCCATCGT GTACTACGTG GGCCGCAAGC CCAAGGTGGA GCAGCTGTCC
AACATGATCG TGCGCTCCTG CAAGTGCAGC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
*
*
*
*