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TGM1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TGM1
Entrez Gene ID 7051
Full Name transglutaminase 1
Synonyms ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q11.2

Summary The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

190195

Disorder Html: Ichthyosis, lamellar, autosomal recessive, 242300 (3); Ichthyosiform

mRNA and Protein(s)

mRNA Protein Name
NM_000359 NP_000350 protein-glutamine gamma-glutamyltransferase K


Homo sapiens (human) TGM1 NP_000350.1
Pan troglodytes (chimpanzee) TGM1 XP_001169496.3
Macaca mulatta (Rhesus monkey) TGM1 XP_001113577.1
Canis lupus familiaris (dog) TGM1 NP_001003079.1
Bos taurus (cattle) TGM1 NP_001010991.1
Mus musculus (house mouse) Tgm1 NP_001155187.1
Rattus norvegicus (Norway rat) Tgm1 NP_113847.1
Danio rerio (zebrafish) LOC100334173 XP_002665624.2
Danio rerio (zebrafish) tgm1l4 NP_001025267.1
Danio rerio (zebrafish) LOC793448 XP_001331914.1
Danio rerio (zebrafish) si:ch1073-138d10.2 XP_005169495.1
Danio rerio (zebrafish) tgm1l1 XP_694950.3
Danio rerio (zebrafish) LOC100535918 XP_003201279.2
Danio rerio (zebrafish) tgm1l2 XP_001332075.5
Drosophila melanogaster (fruit fly) Tg NP_609174.1
Xenopus (Silurana) tropicalis (western clawed frog) tgm1 XP_002939073.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TGM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23436
NM_000359 Homo sapiens transglutaminase 1 (TGM1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23436
Clone ID Related Accession (Same CDS sequence) NM_000359
Accession Version NM_000359.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2454bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein-glutamine gamma-glutamyltransferase K
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA437895.1, BC034699.1 and AL096870.5. This sequence is a reference standard in the RefSeqGene project. On Jul 20, 2006 this sequence version replaced gi:4507474. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034699.1, AK291350.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000350.1
CDS125..2578
Misc Feature(1)65..67(+)
Misc Feature(2)125..424(+)
Misc Feature(3)194..196(+)
Misc Feature(4)368..370(+)
Misc Feature(5)377..379(+)
Misc Feature(6)398..400(+)
Misc Feature(7)452..811(+)
Misc Feature(8)1235..1510(+)
Misc Feature(9)1859..2173(+)
Misc Feature(10)2195..2488(+)
Exon (1)1..122
Gene:TGM1
Gene Synonym:
Exon (2)123..443
Gene:TGM1
Gene Synonym:
Exon (3)444..632
Gene:TGM1
Gene Synonym:
Exon (4)633..881
Gene:TGM1
Gene Synonym:
Exon (5)882..1000
Gene:TGM1
Gene Synonym:
Exon (6)1001..1108
Gene:TGM1
Gene Synonym:
Exon (7)1109..1283
Gene:TGM1
Gene Synonym:
Exon (8)1284..1422
Gene:TGM1
Gene Synonym:
Exon (9)1423..1526
Gene:TGM1
Gene Synonym:
Exon (10)1527..1615
Gene:TGM1
Gene Synonym:
Exon (11)1616..1769
Gene:TGM1
Gene Synonym:
Exon (12)1770..2051
Gene:TGM1
Gene Synonym:
Exon (13)2052..2212
Gene:TGM1
Gene Synonym:
Exon (14)2213..2349
Gene:TGM1
Gene Synonym:
Exon (15)2350..2777
Gene:TGM1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000359
Organism Homo sapiens (human)
Definition Homo sapiens transglutaminase 1 (TGM1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000359

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal
Br. J. Dermatol. 168 (6), 1364-1367 (2013)
Esposito,G., De Falco,F., Neri,I., Graziano,C., Toschi,B., Auricchio,L., Gouveia,C., Sousa,A.B. and Salvatore,F.


book

Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis
J. Dermatol. Sci. 69 (3), 195-201 (2013)
Li H, Vahlquist A and Torma H.


book

Congenital lamellar ichthyosis in Tunisia is caused by a founder nonsense mutation in the TGM1 gene
Mol. Biol. Rep. 40 (3), 2527-2532 (2013)
Louhichi N, Hadjsalem I, Marrakchi S, Trabelsi F, Masmoudi A, Turki H and Fakhfakh F.


book

Transglutaminase-1 mutations in Omani families with lamellar ichthyosis
Med Princ Pract 22 (5), 438-443 (2013)
Al-Naamani A, Al-Waily A, Al-Kindi M, Al-Awadi M and Al-Yahyaee SA.


book

Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis
PLoS ONE 7 (11), E49694 (2012)
Lieden A, Winge MC, Saaf A, Kockum I, Ekelund E, Rodriguez E, Folster-Holst R, Franke A, Illig T, Tengvall-Linder M, Baurecht H, Weidinger S, Wahlgren CF, Nordenskjold M and Bradley M.


book

Autosomal Recessive Congenital Ichthyosis
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Richard,G. and Bale,S.J.


book

Type I keratinocyte transglutaminase: expression in human skin and psoriasis
J. Invest. Dermatol. 99 (1), 27-34 (1992)
Schroeder WT, Thacher SM, Stewart-Galetka S, Annarella M, Chema D, Siciliano MJ, Davies PJ, Tang HY, Sowa BA and Duvic M.


book

Organization and evolution of the human epidermal keratinocyte transglutaminase I gene
Proc. Natl. Acad. Sci. U.S.A. 89 (10), 4476-4480 (1992)
Polakowska RR, Eickbush T, Falciano V, Razvi F and Goldsmith LA.


book

Structure and organization of the human transglutaminase 1 gene
J. Biol. Chem. 267 (11), 7710-7717 (1992)
Kim IG, McBride OW, Wang M, Kim SY, Idler WW and Steinert PM.


book

Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function
J. Biol. Chem. 267 (4), 2282-2286 (1992)
Phillips MA, Stewart BE and Rice RH.


 
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