||ORF Nucleotide Sequence (Length: 702bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||tumor necrosis factor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP215875.1, BC028148.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jul 12, 2012 this sequence version replaced gi:25952110.
Summary: This gene encodes a multifunctional proinflammatory
cytokine that belongs to the tumor necrosis factor (TNF)
superfamily. This cytokine is mainly secreted by macrophages. It
can bind to, and thus functions through its receptors
TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the
regulation of a wide spectrum of biological processes including
cell proliferation, differentiation, apoptosis, lipid metabolism,
and coagulation. This cytokine has been implicated in a variety of
diseases, including autoimmune diseases, insulin resistance, and
cancer. Knockout studies in mice also suggested the neuroprotective
function of this cytokine. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BP215875.1, BC028148.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.