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TNNC2 troponin C type 2 (fast) [Homo sapiens (human)]

Gene Symbol TNNC2
Entrez Gene ID 7125
Full Name troponin C type 2 (fast)
Synonyms
General protein information
Preferred Names
troponin C, skeletal muscle
Names
troponin C, skeletal muscle
troponin C2, fast
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q12-q13.11

Summary Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

191039

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu61061 XM_011529031 PREDICTED: Homo sapiens troponin C type 2 (fast) (TNNC2), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu04113 NM_003279 Homo sapiens troponin C type 2 (fast) (TNNC2), mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu61061D
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product troponin C, skeletal muscle isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011362.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
ATGATCGCTG AGTTCAAGGC TGCCTTTGAC ATGTTTGATG CTGATGGTGG TGGGGACATC 
AGCGTCAAGG AGTTGGGCAC GGTGATGAGG ATGCTGGGCC AGACACCCAC CAAGGAGGAG
CTGGACGCCA TCATCGAGGA GGTGGATGAG GACGGCAGCG GCACCATCGA CTTCGAGGAG
TTCTTGGTCA TGATGGTGCG CCAGATGAAA GAGGACGCGA AAGGGAAGAG CGAGGAGGAG
CTGGCCGAGT GCTTCCGCAT CTTCGACAGG AATGCAGACG GCTACATCGA CCCGGAGGAG
CTGGCTGAGA TTTTCAGGGC CTCCGGGGAG CACGTGACGG ACGAGGAGAT CGAATCTCTG
ATGAAAGACG GCGACAAGAA CAACGACGGC CGCATTGACT TCGACGAGTT CCTGAAGATG
ATGGAGGGCG TGCAGTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_011527333.1
CDS116..553
Misc Feature(1)119..538(+)
Misc Feature(2)125..310(+)
Misc Feature(3)152..295(+)
Misc Feature(4)353..538(+)
Misc Feature(5)380..523(+)
Translation
Position Chain Variation Link
36 36 a, g dbSNP:138850420
76 76 a, g dbSNP:148902583
84 84 -, a dbSNP:748284133
91 91 a, g dbSNP:758747212
95 95 a, t dbSNP:750235721
102 102 a, c, g dbSNP:757123813
109 109 c, g, t dbSNP:201715509
122 122 a, g dbSNP:760239020
131 131 a, g dbSNP:752200112
146 146 a, t dbSNP:767061349
174 174 c, t dbSNP:11538663
175 175 c, g dbSNP:759139207
189 189 g, t dbSNP:751242468
190 190 c, g dbSNP:765452057
196 196 a, g dbSNP:145593698
213 213 a, g dbSNP:370018843
217 217 a, g dbSNP:769198477
223 223 c, t dbSNP:569859219
226 226 c, t dbSNP:775693770
229 229 a, g dbSNP:144632671
231 231 a, g dbSNP:746050749
241 241 c, t dbSNP:779204356
251 251 a, g dbSNP:770576553
253 253 g, t dbSNP:749098799
271 271 c, t dbSNP:748011299
277 277 a, c dbSNP:781120573
283 283 c, g dbSNP:754962399
307 307 g, t dbSNP:1804548
314 314 c, t dbSNP:746513021
315 315 a, g dbSNP:779467761
331 331 c, g dbSNP:758043604
332 332 g, t dbSNP:750069128
333 333 c, t dbSNP:764481639
340 340 a, g dbSNP:756556811
358 358 a, g dbSNP:753200493
361 361 c, t dbSNP:768125152
379 379 c, t dbSNP:760186895
383 383 a, g, t dbSNP:766419408
387 387 a, g dbSNP:771556542
398 398 c, t dbSNP:745359680
401 401 a, c, g dbSNP:770676074
404 404 a, c, g dbSNP:140683159
408 408 c, t dbSNP:755301842
409 409 c, g dbSNP:752044516
420 420 c, t dbSNP:780412349
434 434 a, g dbSNP:759010637
435 435 c, t dbSNP:763474829
440 440 a, g dbSNP:750467694
442 442 c, g dbSNP:765348042
445 445 a, g dbSNP:201505970
448 448 c, g dbSNP:754093865
453 453 c, t dbSNP:373881224
454 454 g, t dbSNP:4629
460 460 a, g dbSNP:555536943
464 464 a, c dbSNP:771899470
466 466 c, t dbSNP:759558973
467 467 c, g dbSNP:773978463
469 469 -, at dbSNP:763547902
470 470 a, t dbSNP:770588170
475 475 c, g dbSNP:371766471
485 485 a, g dbSNP:139378430
487 487 a, c dbSNP:769543985
501 501 a, g dbSNP:747329067
502 502 c, t dbSNP:780503233
503 503 c, g dbSNP:781622000
507 507 g, t dbSNP:758805359
510 510 c, t dbSNP:113240353
517 517 a, c dbSNP:778920626
520 520 c, t dbSNP:757336473
528 528 c, t dbSNP:772514556
532 532 g, t dbSNP:746310393
545 545 a, g dbSNP:777709485
546 546 c, t dbSNP:757823227
549 549 a, g dbSNP:749368853
558 558 c, t dbSNP:777950314
567 567 a, g dbSNP:756267886
574 574 c, t dbSNP:752988478
581 581 c, t dbSNP:767179127
582 582 a, g dbSNP:754831546
583 583 c, t dbSNP:751456774
584 584 a, g dbSNP:766413846
589 589 c, t dbSNP:763023883
594 594 a, g dbSNP:772570739
597 597 a, g, t dbSNP:188125171
608 608 c, t dbSNP:748047781
616 616 c, t dbSNP:541482010
622 622 c, t dbSNP:35280117
639 639 a, g dbSNP:8860
645 645 -, t dbSNP:750519370
652 652 a, c dbSNP:566203404
659 659 g, t dbSNP:547915744
675 675 a, g dbSNP:754718279

Target ORF information:

RefSeq Version XM_011529031
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens troponin C type 2 (fast) (TNNC2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_011529031

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGATCGCTG AGTTCAAGGC TGCCTTTGAC ATGTTTGATG CTGATGGTGG TGGGGACATC 
AGCGTCAAGG AGTTGGGCAC GGTGATGAGG ATGCTGGGCC AGACACCCAC CAAGGAGGAG
CTGGACGCCA TCATCGAGGA GGTGGATGAG GACGGCAGCG GCACCATCGA CTTCGAGGAG
TTCTTGGTCA TGATGGTGCG CCAGATGAAA GAGGACGCGA AAGGGAAGAG CGAGGAGGAG
CTGGCCGAGT GCTTCCGCAT CTTCGACAGG AATGCAGACG GCTACATCGA CCCGGAGGAG
CTGGCTGAGA TTTTCAGGGC CTCCGGGGAG CACGTGACGG ACGAGGAGAT CGAATCTCTG
ATGAAAGACG GCGACAAGAA CAACGACGGC CGCATTGACT TCGACGAGTT CCTGAAGATG
ATGGAGGGCG TGCAGTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu04113D
Sequence Information ORF Nucleotide Sequence (Length: 483bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product troponin C, skeletal muscle
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU854061.1, AI080746.1 and BC005323.1. On Jan 13, 2004 this sequence version replaced gi:4507616. Summary: Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF576408.1, BC005323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946, SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGACGGACC AGCAGGCTGA GGCCAGGTCC TACCTCAGCG AAGAGATGAT CGCTGAGTTC 
AAGGCTGCCT TTGACATGTT TGATGCTGAT GGTGGTGGGG ACATCAGCGT CAAGGAGTTG
GGCACGGTGA TGAGGATGCT GGGCCAGACA CCCACCAAGG AGGAGCTGGA CGCCATCATC
GAGGAGGTGG ATGAGGACGG CAGCGGCACC ATCGACTTCG AGGAGTTCTT GGTCATGATG
GTGCGCCAGA TGAAAGAGGA CGCGAAAGGG AAGAGCGAGG AGGAGCTGGC CGAGTGCTTC
CGCATCTTCG ACAGGAATGC AGACGGCTAC ATCGACCCGG AGGAGCTGGC TGAGATTTTC
AGGGCCTCCG GGGAGCACGT GACGGACGAG GAGATCGAAT CTCTGATGAA AGACGGCGAC
AAGAACAACG ACGGCCGCAT TGACTTCGAC GAGTTCCTGA AGATGATGGA GGGCGTGCAG
TAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_003270.1
CDS67..549
Misc Feature(1)70..72(+)
Misc Feature(2)100..534(+)
Misc Feature(3)121..306(+)
Misc Feature(4)148..291(+)
Misc Feature(5)349..534(+)
Misc Feature(6)376..519(+)
Exon (1)1..69
Gene:TNNC2
Gene Synonym:
Exon (2)70..121
Gene:TNNC2
Gene Synonym:
Exon (3)122..265
Gene:TNNC2
Gene Synonym:
Exon (4)266..380
Gene:TNNC2
Gene Synonym:
Exon (5)381..517
Gene:TNNC2
Gene Synonym:
Exon (6)518..683
Gene:TNNC2
Gene Synonym:
Translation
Position Chain Variation Link
31 31 c, t dbSNP:756129331
32 32 a, g dbSNP:748164656
37 37 a, g dbSNP:781373134
38 38 c, t dbSNP:755132167
40 40 a, g dbSNP:751828175
41 41 c, t dbSNP:766233819
45 45 -, agag dbSNP:772245620
52 52 c, g, t dbSNP:754727107
53 53 a, g dbSNP:199528760
56 56 c, t dbSNP:761880667
59 59 a, c dbSNP:775977578
64 64 a, g dbSNP:116367119
72 72 a, g dbSNP:148902583
80 80 -, a dbSNP:748284133
87 87 a, g dbSNP:758747212
91 91 a, t dbSNP:750235721
98 98 a, c, g dbSNP:757123813
105 105 c, g, t dbSNP:201715509
118 118 a, g dbSNP:760239020
127 127 a, g dbSNP:752200112
142 142 a, t dbSNP:767061349
170 170 c, t dbSNP:11538663
171 171 c, g dbSNP:759139207
185 185 g, t dbSNP:751242468
186 186 c, g dbSNP:765452057
192 192 a, g dbSNP:145593698
209 209 a, g dbSNP:370018843
213 213 a, g dbSNP:769198477
219 219 c, t dbSNP:569859219
222 222 c, t dbSNP:775693770
225 225 a, g dbSNP:144632671
227 227 a, g dbSNP:746050749
237 237 c, t dbSNP:779204356
247 247 a, g dbSNP:770576553
249 249 g, t dbSNP:749098799
267 267 c, t dbSNP:748011299
273 273 a, c dbSNP:781120573
279 279 c, g dbSNP:754962399
303 303 g, t dbSNP:1804548
310 310 c, t dbSNP:746513021
311 311 a, g dbSNP:779467761
327 327 c, g dbSNP:758043604
328 328 g, t dbSNP:750069128
329 329 c, t dbSNP:764481639
336 336 a, g dbSNP:756556811
354 354 a, g dbSNP:753200493
357 357 c, t dbSNP:768125152
375 375 c, t dbSNP:760186895
379 379 a, g, t dbSNP:766419408
383 383 a, g dbSNP:771556542
394 394 c, t dbSNP:745359680
397 397 a, c, g dbSNP:770676074
400 400 a, c, g dbSNP:140683159
404 404 c, t dbSNP:755301842
405 405 c, g dbSNP:752044516
416 416 c, t dbSNP:780412349
430 430 a, g dbSNP:759010637
431 431 c, t dbSNP:763474829
436 436 a, g dbSNP:750467694
438 438 c, g dbSNP:765348042
441 441 a, g dbSNP:201505970
444 444 c, g dbSNP:754093865
449 449 c, t dbSNP:373881224
450 450 g, t dbSNP:4629
456 456 a, g dbSNP:555536943
460 460 a, c dbSNP:771899470
462 462 c, t dbSNP:759558973
463 463 c, g dbSNP:773978463
465 465 -, at dbSNP:763547902
466 466 a, t dbSNP:770588170
471 471 c, g dbSNP:371766471
481 481 a, g dbSNP:139378430
483 483 a, c dbSNP:769543985
497 497 a, g dbSNP:747329067
498 498 c, t dbSNP:780503233
499 499 c, g dbSNP:781622000
503 503 g, t dbSNP:758805359
506 506 c, t dbSNP:113240353
513 513 a, c dbSNP:778920626
516 516 c, t dbSNP:757336473
524 524 c, t dbSNP:772514556
528 528 g, t dbSNP:746310393
541 541 a, g dbSNP:777709485
542 542 c, t dbSNP:757823227
545 545 a, g dbSNP:749368853
554 554 c, t dbSNP:777950314
563 563 a, g dbSNP:756267886
570 570 c, t dbSNP:752988478
577 577 c, t dbSNP:767179127
578 578 a, g dbSNP:754831546
579 579 c, t dbSNP:751456774
580 580 a, g dbSNP:766413846
585 585 c, t dbSNP:763023883
590 590 a, g dbSNP:772570739
593 593 a, g, t dbSNP:188125171
604 604 c, t dbSNP:748047781
612 612 c, t dbSNP:541482010
618 618 c, t dbSNP:35280117
635 635 a, g dbSNP:8860
641 641 -, t dbSNP:750519370
648 648 a, c dbSNP:566203404
655 655 g, t dbSNP:547915744
671 671 a, g dbSNP:754718279

Target ORF information:

RefSeq Version NM_003279
Organism Homo sapiens (human)
Definition Homo sapiens troponin C type 2 (fast) (TNNC2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_003279

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGACGGACC AGCAGGCTGA GGCCAGGTCC TACCTCAGCG AAGAGATGAT CGCTGAGTTC 
AAGGCTGCCT TTGACATGTT TGATGCTGAT GGTGGTGGGG ACATCAGCGT CAAGGAGTTG
GGCACGGTGA TGAGGATGCT GGGCCAGACA CCCACCAAGG AGGAGCTGGA CGCCATCATC
GAGGAGGTGG ATGAGGACGG CAGCGGCACC ATCGACTTCG AGGAGTTCTT GGTCATGATG
GTGCGCCAGA TGAAAGAGGA CGCGAAAGGG AAGAGCGAGG AGGAGCTGGC CGAGTGCTTC
CGCATCTTCG ACAGGAATGC AGACGGCTAC ATCGACCCGG AGGAGCTGGC TGAGATTTTC
AGGGCCTCCG GGGAGCACGT GACGGACGAG GAGATCGAAT CTCTGATGAA AGACGGCGAC
AAGAACAACG ACGGCCGCAT TGACTTCGAC GAGTTCCTGA AGATGATGGA GGGCGTGCAG
TAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.