The following TNNI3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNNI3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 633bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||troponin I, cardiac muscle
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK223451.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 5, 2007 this sequence version replaced gi:30141909.
Summary: Troponin I (TnI), along with troponin T (TnT) and troponin
C (TnC), is one of 3 subunits that form the troponin complex of the
thin filaments of striated muscle. TnI is the inhibitory subunit;
blocking actin-myosin interactions and thereby mediating striated
muscle relaxation. The TnI subfamily contains three genes:
TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and
TnI-cardiac. This gene encodes the TnI-cardiac protein and is
exclusively expressed in cardiac muscle tissues. Mutations in this
gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and
familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK223451.1, EU747720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.