||ORF Nucleotide Sequence (Length: 633bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||troponin I, cardiac muscle
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK223451.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 5, 2007 this sequence version replaced gi:30141909.
Summary: Troponin I (TnI), along with troponin T (TnT) and troponin
C (TnC), is one of 3 subunits that form the troponin complex of the
thin filaments of striated muscle. TnI is the inhibitory subunit;
blocking actin-myosin interactions and thereby mediating striated
muscle relaxation. The TnI subfamily contains three genes:
TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and
TnI-cardiac. This gene encodes the TnI-cardiac protein and is
exclusively expressed in cardiac muscle tissues. Mutations in this
gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and
familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK223451.1, EU747720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.