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TNNI3 troponin I type 3 (cardiac) [Homo sapiens (human)]

Gene Symbol TNNI3
Entrez Gene ID 7137
Full Name troponin I type 3 (cardiac)
Synonyms CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
General protein information
Preferred Names
troponin I, cardiac muscle
Names
troponin I, cardiac muscle
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.4

Summary Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

191044

Disorder Html: Cardiomyopathy, familial hypertrophic, 7, 613690 (3); Cardiomyopathy,





The following TNNI3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNNI3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25717 NM_000363 Homo sapiens troponin I type 3 (cardiac) (TNNI3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$269

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu25717
Accession Version NM_000363.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 633bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu25717D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product troponin I, cardiac muscle
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223451.1. This sequence is a reference standard in the RefSeqGene project. On Jul 5, 2007 this sequence version replaced gi:30141909. Summary: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223451.1, EU747720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGGCGGATG GGAGCAGCGA TGCGGCTAGG GAACCTCGCC CTGCACCAGC CCCAATCAGA 
CGCCGCTCCT CCAACTACCG CGCTTATGCC ACGGAGCCGC ACGCCAAGAA AAAATCTAAG
ATCTCCGCCT CGAGAAAATT GCAGCTGAAG ACTCTGCTGC TGCAGATTGC AAAGCAAGAG
CTGGAGCGAG AGGCGGAGGA GCGGCGCGGA GAGAAGGGGC GCGCTCTGAG CACCCGCTGC
CAGCCGCTGG AGTTGGCCGG GCTGGGCTTC GCGGAGCTGC AGGACTTGTG CCGACAGCTC
CACGCCCGTG TGGACAAGGT GGATGAAGAG AGATACGACA TAGAGGCAAA AGTCACCAAG
AACATCACGG AGATTGCAGA TCTGACTCAG AAGATCTTTG ACCTTCGAGG CAAGTTTAAG
CGGCCCACCC TGCGGAGAGT GAGGATCTCT GCAGATGCCA TGATGCAGGC GCTGCTGGGG
GCCCGGGCTA AGGAGTCCCT GGACCTGCGG GCCCACCTCA AGCAGGTGAA GAAGGAGGAC
ACCGAGAAGG AAAACCGGGA GGTGGGAGAC TGGCGCAAGA ACATCGATGC ACTGAGTGGA
ATGGAGGGCC GCAAGAAAAA GTTTGAGAGC TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000354.4
CDS144..776
Misc Feature(1)144..236(+)
Misc Feature(2)147..149(+)
Misc Feature(3)156..158(+)
Misc Feature(4)159..161(+)
Misc Feature(5)210..212(+)
Misc Feature(6)213..215(+)
Misc Feature(7)219..221(+)
Misc Feature(8)234..236(+)
Misc Feature(9)237..380(+)
Misc Feature(10)294..296(+)
Misc Feature(11)357..623(+)
Misc Feature(12)372..374(+)
Misc Feature(13)375..377(+)
Misc Feature(14)381..383(+)
Misc Feature(15)432..434(+)
Misc Feature(16)528..590(+)
Misc Feature(17)528..530(+)
Misc Feature(18)570..572(+)
Misc Feature(19)591..593(+)
Misc Feature(20)639..641(+)
Misc Feature(21)684..686(+)
Misc Feature(22)738..740(+)
Exon (1)1..154
Gene:TNNI3
Gene Synonym:
Exon (2)155..167
Gene:TNNI3
Gene Synonym:
Exon (3)168..251
Gene:TNNI3
Gene Synonym:
Exon (4)252..293
Gene:TNNI3
Gene Synonym:
Exon (5)294..425
Gene:TNNI3
Gene Synonym:
Exon (6)426..515
Gene:TNNI3
Gene Synonym:
Exon (7)516..692
Gene:TNNI3
Gene Synonym:
Exon (8)693..843
Gene:TNNI3
Gene Synonym:
Translation
Position Chain Variation Link
2 2 a, g dbSNP:755256736
9 9 c, t dbSNP:754024420
28 28 a, c, t dbSNP:555483433
30 30 a, g dbSNP:554755235
31 31 a, g dbSNP:538294792
32 32 a, g dbSNP:767289521
37 37 c, t dbSNP:761398360
41 41 c, t dbSNP:557391836
42 42 a, g dbSNP:763668988
46 46 a, c, t dbSNP:12973773
47 47 c, t dbSNP:771456864
48 48 c, t dbSNP:761058069
59 59 a, c dbSNP:186540595
67 67 a, c, t dbSNP:181036338
68 68 a, g dbSNP:748681078
71 71 c, t dbSNP:376861481
76 76 c, t dbSNP:569322461
86 86 a, c dbSNP:768695532
95 95 c, t dbSNP:749534125
97 97 c, t dbSNP:202159627
100 100 c, t dbSNP:755906283
108 108 a, g dbSNP:560901632
109 109 a, c dbSNP:3729707
114 114 c, t dbSNP:757183182
115 115 c, t dbSNP:751492474
117 117 c, t dbSNP:763720213
122 122 c, g dbSNP:757944627
126 126 a, c dbSNP:752407016
128 128 c, t dbSNP:371665059
129 129 a, g dbSNP:530600518
130 130 a, g dbSNP:759215889
136 136 a, g dbSNP:773513015
138 138 a, c dbSNP:767890375
144 144 a, g dbSNP:397516341
148 148 c, t dbSNP:397516359
149 149 a, g, t dbSNP:397516361
155 155 c, g dbSNP:746102505
164 164 c, t dbSNP:776875171
166 166 c, t dbSNP:770640091
167 167 a, g dbSNP:746763585
169 169 c, t dbSNP:771967539
177 177 a, c, t dbSNP:553214254
178 178 c, t dbSNP:768052584
182 182 c, g dbSNP:397516346
188 188 a, c dbSNP:377421427
195 195 a, c dbSNP:779416591
198 198 a, g dbSNP:755862334
200 200 a, c, g dbSNP:778133452
204 204 c, t dbSNP:267607128
208 208 a, g dbSNP:397516360
215 215 c, g dbSNP:758724238
228 228 g, t dbSNP:727503510
235 235 c, t dbSNP:201928445
236 236 c, g dbSNP:765719980
242 242 -, agccg dbSNP:760306570
244 244 a, t dbSNP:759949951
248 248 a, c dbSNP:397516339
249 249 a, c dbSNP:267607130
257 257 -, a dbSNP:772607683
257 257 a, t dbSNP:730881066
270 270 g, t dbSNP:727505023
274 274 c, g dbSNP:730881085
275 275 c, g dbSNP:727504941
282 282 c, t dbSNP:587780967
286 286 a, c, t dbSNP:200720341
293 293 a, g dbSNP:730881086
300 300 c, g dbSNP:763981651
301 301 g, t dbSNP:762589736
307 307 a, c dbSNP:775512887
309 309 a, g dbSNP:765219322
310 310 c, t dbSNP:545441942
311 311 g, t dbSNP:727503509
321 321 c, g dbSNP:776162352
341 341 a, g dbSNP:3729710
343 343 a, t dbSNP:760401006
345 345 a, c dbSNP:772695512
347 347 -, g dbSNP:727504872
347 347 g, t dbSNP:3729711
350 350 a, c, g dbSNP:201422579
351 351 a, g dbSNP:730881067
356 356 a, g dbSNP:770487905
363 363 a, c, g dbSNP:375795196
375 375 a, t dbSNP:786204399
376 376 c, g dbSNP:786205288
378 378 c, t dbSNP:3729712
379 379 g, t dbSNP:397516342
382 382 a, g dbSNP:777801855
387 387 c, t dbSNP:77615401
388 388 c, g dbSNP:752503819
389 389 a, g, t dbSNP:397516343
393 393 c, g dbSNP:759523214
401 401 -, c dbSNP:727503507
401 401 c, g, t dbSNP:727503508
406 406 g, t dbSNP:760033874
407 407 g, t dbSNP:772928416
415 415 c, t dbSNP:771678310
416 416 a, g dbSNP:75491697
421 421 c, t dbSNP:776035548
435 435 c, g, t dbSNP:730881068
436 436 a, g dbSNP:747522089
441 441 c, t dbSNP:773216333
443 443 c, g dbSNP:772145171
445 445 a, g dbSNP:730881087
446 446 c, t dbSNP:199539066
447 447 a, g dbSNP:374618872
450 450 c, t dbSNP:397516344
451 451 a, g, t dbSNP:371000425
452 452 c, t dbSNP:749136271
455 455 a, g dbSNP:779892594
461 461 a, c, g dbSNP:750350912
465 465 a, g dbSNP:766958196
474 474 a, g dbSNP:730881088
479 479 -, t dbSNP:35173650
479 479 c, t dbSNP:559450042
480 480 a, g dbSNP:779064799
482 482 c, t dbSNP:786204400
483 483 a, g dbSNP:730881070
484 484 c, t dbSNP:762692450
490 490 c, g dbSNP:777177571
499 499 a, c, t dbSNP:184709702
500 500 c, t dbSNP:761112430
506 506 c, t dbSNP:371490136
511 511 c, t dbSNP:397516345
512 512 a, g dbSNP:748164248
513 513 c, g dbSNP:727503506
527 527 a, g, t dbSNP:373130533
544 544 a, g dbSNP:727503505
550 550 a, g dbSNP:730881069
563 563 a, g dbSNP:764190541
564 564 c, t dbSNP:730881071
565 565 a, g dbSNP:397516347
569 569 c, t dbSNP:532949659
571 571 a, c dbSNP:397516348
574 574 a, c, t dbSNP:121917760
575 575 c, g, t dbSNP:776615304
576 576 c, g, t dbSNP:104894724
577 577 a, g dbSNP:397516349
582 582 c, g dbSNP:777782551
594 594 a, g dbSNP:730881072
601 601 a, c dbSNP:730881073
605 605 a, g dbSNP:397516350
606 606 a, g dbSNP:730881074
607 607 c, t dbSNP:397516352
613 613 c, t dbSNP:397516353
614 614 a, g dbSNP:747756509
617 617 c, g dbSNP:749880457
620 620 c, g dbSNP:754703054
625 625 c, t dbSNP:753413305
627 627 c, t dbSNP:368861241
628 628 a, c, g dbSNP:397516354
631 631 c, t dbSNP:727504367
634 634 a, c dbSNP:546367368
640 640 c, t dbSNP:727504242
651 651 c, g, t dbSNP:727503504
652 652 a, g dbSNP:727503503
654 654 a, g dbSNP:121917761
657 657 c, g dbSNP:730881075
659 659 c, t dbSNP:764527627
662 662 c, t dbSNP:758827138
664 664 a, c dbSNP:730881076
665 665 c, g dbSNP:730880231
668 668 c, g dbSNP:727503502
669 669 a, g dbSNP:727503501
675 675 -, aag dbSNP:397516351
675 675 a, g dbSNP:104894730
680 680 a, g dbSNP:3729841
684 684 a, g dbSNP:765207816
687 687 a, g dbSNP:397516355
690 690 a, g dbSNP:730881077
691 691 a, c dbSNP:730881078
693 693 a, g dbSNP:397516356
696 696 a, t dbSNP:730881089
697 697 a, g dbSNP:730881079
698 698 c, g dbSNP:267607129
699 699 c, t dbSNP:760978512
700 700 a, g dbSNP:397516357
702 702 a, g dbSNP:727505069
704 704 g, t dbSNP:773184959
705 705 a, g, t dbSNP:193922409
707 707 a, g dbSNP:767197546
709 709 a, g dbSNP:587782980
711 711 g, t dbSNP:727503500
712 712 a, g dbSNP:104894728
717 717 c, t dbSNP:727503499
718 718 a, c, g, t dbSNP:104894729
720 720 a, g dbSNP:730881080
722 722 c, g, t dbSNP:397516358
724 724 a, c, g dbSNP:730881081
725 725 c, g dbSNP:730881090
728 728 c, t dbSNP:200085986
729 729 a, g, t dbSNP:104894727
734 734 a, g dbSNP:748738767
735 735 c, g dbSNP:727504285
739 739 a, g dbSNP:730881091
745 745 c, t dbSNP:727504365
746 746 c, g dbSNP:774968223
750 750 a, g dbSNP:267607127
752 752 c, t dbSNP:587780968
753 753 c, t dbSNP:727504243
754 754 a, g, t dbSNP:727504275
756 756 a, c dbSNP:727505331
759 759 a, c, g dbSNP:104894725
760 760 a, t dbSNP:730881082
763 763 a, g dbSNP:367672692
768 768 a, g dbSNP:727504268
769 769 a, c dbSNP:730881083
775 775 g, t dbSNP:730881084
792 792 a, g dbSNP:778220410
793 793 c, t dbSNP:758648059
798 798 a, g dbSNP:55792205
799 799 a, c dbSNP:748691187
809 809 c, g dbSNP:546541003
811 811 c, t dbSNP:375447438
815 815 a, g dbSNP:754034217
818 818 a, g dbSNP:184858206
824 824 a, g dbSNP:756457017

Target ORF information:

RefSeq Version NM_000363
Organism Homo sapiens (human)
Definition Homo sapiens troponin I type 3 (cardiac) (TNNI3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000363

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCGGATG GGAGCAGCGA TGCGGCTAGG GAACCTCGCC CTGCACCAGC CCCAATCAGA 
CGCCGCTCCT CCAACTACCG CGCTTATGCC ACGGAGCCGC ACGCCAAGAA AAAATCTAAG
ATCTCCGCCT CGAGAAAATT GCAGCTGAAG ACTCTGCTGC TGCAGATTGC AAAGCAAGAG
CTGGAGCGAG AGGCGGAGGA GCGGCGCGGA GAGAAGGGGC GCGCTCTGAG CACCCGCTGC
CAGCCGCTGG AGTTGGCCGG GCTGGGCTTC GCGGAGCTGC AGGACTTGTG CCGACAGCTC
CACGCCCGTG TGGACAAGGT GGATGAAGAG AGATACGACA TAGAGGCAAA AGTCACCAAG
AACATCACGG AGATTGCAGA TCTGACTCAG AAGATCTTTG ACCTTCGAGG CAAGTTTAAG
CGGCCCACCC TGCGGAGAGT GAGGATCTCT GCAGATGCCA TGATGCAGGC GCTGCTGGGG
GCCCGGGCTA AGGAGTCCCT GGACCTGCGG GCCCACCTCA AGCAGGTGAA GAAGGAGGAC
ACCGAGAAGG AAAACCGGGA GGTGGGAGAC TGGCGCAAGA ACATCGATGC ACTGAGTGGA
ATGGAGGGCC GCAAGAAAAA GTTTGAGAGC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.