×

TTPA cDNA ORF clone, Homo sapiens (human)

Gene Symbol TTPA
Entrez Gene ID 7274
Full Name tocopherol (alpha) transfer protein
Synonyms ATTP, AVED, TTP1, alphaTTP
General protein information
Preferred Names
alpha-tocopherol transfer protein
Names
alpha-tocopherol transfer protein
alpha-TTP
tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q12.3

Summary This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]. lac of sum
Disorder MIM:

600415

Disorder Html: Ataxia with isolated vitamin E deficiency, 277460 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006716468 XP_006716531 alpha-tocopherol transfer protein isoform X1
NM_000370 NP_000361 alpha-tocopherol transfer protein


Homo sapiens (human) TTPA NP_000361.1
Pan troglodytes (chimpanzee) TTPA XP_528150.2
Macaca mulatta (Rhesus monkey) TTPA XP_001092014.1
Canis lupus familiaris (dog) TTPA XP_005638207.1
Bos taurus (cattle) TTPA NP_001193605.1
Mus musculus (house mouse) Ttpa NP_056582.1
Rattus norvegicus (Norway rat) Ttpa NP_037180.1
Gallus gallus (chicken) TTPA XP_001234376.2
Danio rerio (zebrafish) ttpa NP_956025.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TTPA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TTPA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu42296 XM_006716468 PREDICTED: Homo sapiens tocopherol (alpha) transfer protein (TTPA), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu23197 NM_000370 Homo sapiens tocopherol (alpha) transfer protein (TTPA), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu42296
Clone ID Related Accession (Same CDS sequence) XM_006716468
Accession Version XM_006716468.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 489bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product alpha-tocopherol transfer protein isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_008183.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578815702. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGCAGAGG CGCGATCCCA GCCCTCGGCG GGGCCGCAGC TCAACGCGCT ACCGGACCAC 
TCTCCGTTGC TGCAGCCGGG CCTGGCGGCG CTGCGGCGCC GGGCCCGGGA AGCTGGCGTC
CCGCTCGCGC CGCTGCCGCT CACCGACTCC TTCCTGCTGC GGTTCCTGCG CGCCCGGGAT
TTCGATCTGG ACCTGGCCTG GCGGGATTCA TTTCCATTGA AAGTTCGTGG CATCCATTTG
ATAAATGAAC CAGTAATTTT CCATGCTGTC TTTTCCATGA TCAAACCATT CCTGACTGAA
AAAATTAAGG AACGGATTCA CATGCATGGG AACAACTACA AACAAAGCTT GCTTCAGCAT
TTCCCAGACA TTCTTCCTCT GGAATATGGT GGTGAAGAAT TCTCCATGGA GGACATTTGT
CAGGAATGGA CAAATTTTAT AATGAAGTCT GAAGATTATC TCAGCAGCAT TTCTGAGAGC
ATTCAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006716531.1
CDS80..568
Misc Feature(1)194..475(+)
Misc Feature(2)233..397(+)
Misc Feature(3)296..394(+)
Translation

Target ORF information:

RefSeq Version XM_006716468
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens tocopherol (alpha) transfer protein (TTPA), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006716468

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCAGAGG CGCGATCCCA GCCCTCGGCG GGGCCGCAGC TCAACGCGCT ACCGGACCAC 
TCTCCGTTGC TGCAGCCGGG CCTGGCGGCG CTGCGGCGCC GGGCCCGGGA AGCTGGCGTC
CCGCTCGCGC CGCTGCCGCT CACCGACTCC TTCCTGCTGC GGTTCCTGCG CGCCCGGGAT
TTCGATCTGG ACCTGGCCTG GCGGGATTCA TTTCCATTGA AAGTTCGTGG CATCCATTTG
ATAAATGAAC CAGTAATTTT CCATGCTGTC TTTTCCATGA TCAAACCATT CCTGACTGAA
AAAATTAAGG AACGGATTCA CATGCATGGG AACAACTACA AACAAAGCTT GCTTCAGCAT
TTCCCAGACA TTCTTCCTCT GGAATATGGT GGTGAAGAAT TCTCCATGGA GGACATTTGT
CAGGAATGGA CAAATTTTAT AATGAAGTCT GAAGATTATC TCAGCAGCAT TTCTGAGAGC
ATTCAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23197
Clone ID Related Accession (Same CDS sequence) NM_000370
Accession Version NM_000370.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 837bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-tocopherol transfer protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC058000.1, BC041784.1 and AC120042.3. This sequence is a reference standard in the RefSeqGene project. On Nov 4, 2009 this sequence version replaced gi:50592999. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058000.1, BC041784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAGG CGCGATCCCA GCCCTCGGCG GGGCCGCAGC TCAACGCGCT ACCGGACCAC 
TCTCCGTTGC TGCAGCCGGG CCTGGCGGCG CTGCGGCGCC GGGCCCGGGA AGCTGGCGTC
CCGCTCGCGC CGCTGCCGCT CACCGACTCC TTCCTGCTGC GGTTCCTGCG CGCCCGGGAT
TTCGATCTGG ACCTGGCCTG GCGGTTACTA AAAAACTATT ATAAGTGGAG AGCAGAATGT
CCAGAAATAA GTGCAGATCT ACACCCTAGA AGTATTATTG GCCTCCTAAA GGCTGGCTAC
CATGGAGTCC TGAGATCCAG GGATCCCACT GGCAGCAAAG TTCTTATTTA CAGAATCGCA
CACTGGGACC CCAAAGTTTT TACAGCTTAT GACGTATTTC GAGTAAGTCT AATCACATCC
GAGCTTATTG TACAGGAGGT AGAAACTCAG CGGAATGGAA TCAAGGCTAT CTTTGATCTG
GAAGGTTGGC AGTTTTCTCA TGCTTTTCAA ATCACTCCAT CCGTAGCCAA GAAGATTGCT
GCTGTACTTA CGGATTCATT TCCATTGAAA GTTCGTGGCA TCCATTTGAT AAATGAACCA
GTAATTTTCC ATGCTGTCTT TTCCATGATC AAACCATTCC TGACTGAAAA AATTAAGGAA
CGGATTCACA TGCATGGGAA CAACTACAAA CAAAGCTTGC TTCAGCATTT CCCAGACATT
CTTCCTCTGG AATATGGTGG TGAAGAATTC TCCATGGAGG ACATTTGTCA GGAATGGACA
AATTTTATAA TGAAGTCTGA AGATTATCTC AGCAGCATTT CTGAGAGCAT TCAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000361.1
CDS33..869
Misc Feature(1)150..251(+)
Misc Feature(2)315..776(+)
Misc Feature(3)369..698(+)
Misc Feature(4)597..695(+)
Exon (1)1..236
Gene:TTPA
Gene Synonym:
Exon (2)237..390
Gene:TTPA
Gene Synonym:
Exon (3)391..584
Gene:TTPA
Gene Synonym:
Exon (4)585..695
Gene:TTPA
Gene Synonym:
Exon (5)696..2633
Gene:TTPA
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000370
Organism Homo sapiens (human)
Definition Homo sapiens tocopherol (alpha) transfer protein (TTPA), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000370

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGAGG CGCGATCCCA GCCCTCGGCG GGGCCGCAGC TCAACGCGCT ACCGGACCAC 
TCTCCGTTGC TGCAGCCGGG CCTGGCGGCG CTGCGGCGCC GGGCCCGGGA AGCTGGCGTC
CCGCTCGCGC CGCTGCCGCT CACCGACTCC TTCCTGCTGC GGTTCCTGCG CGCCCGGGAT
TTCGATCTGG ACCTGGCCTG GCGGTTACTA AAAAACTATT ATAAGTGGAG AGCAGAATGT
CCAGAAATAA GTGCAGATCT ACACCCTAGA AGTATTATTG GCCTCCTAAA GGCTGGCTAC
CATGGAGTCC TGAGATCCAG GGATCCCACT GGCAGCAAAG TTCTTATTTA CAGAATCGCA
CACTGGGACC CCAAAGTTTT TACAGCTTAT GACGTATTTC GAGTAAGTCT AATCACATCC
GAGCTTATTG TACAGGAGGT AGAAACTCAG CGGAATGGAA TCAAGGCTAT CTTTGATCTG
GAAGGTTGGC AGTTTTCTCA TGCTTTTCAA ATCACTCCAT CCGTAGCCAA GAAGATTGCT
GCTGTACTTA CGGATTCATT TCCATTGAAA GTTCGTGGCA TCCATTTGAT AAATGAACCA
GTAATTTTCC ATGCTGTCTT TTCCATGATC AAACCATTCC TGACTGAAAA AATTAAGGAA
CGGATTCACA TGCATGGGAA CAACTACAAA CAAAGCTTGC TTCAGCATTT CCCAGACATT
CTTCCTCTGG AATATGGTGG TGAAGAATTC TCCATGGAGG ACATTTGTCA GGAATGGACA
AATTTTATAA TGAAGTCTGA AGATTATCTC AGCAGCATTT CTGAGAGCAT TCAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
*
*
*
*