The following TTR gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TTR gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||Documents for ORF clone product in dufault vector
||ORF Nucleotide Sequence (Length: 444bp)
||pcDNA3.1+/C-(K)DYK or customized vector
||Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
||Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Document: OHu27033D_COA.pdf (pdf)
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB498675.1, BC020791.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jan 22, 2009 this sequence version replaced gi:167736363.
Summary: This gene encodes transthyretin, one of the three
prealbumins including alpha-1-antitrypsin, transthyretin and
orosomucoid. Transthyretin is a carrier protein; it transports
thyroid hormones in the plasma and cerebrospinal fluid, and also
transports retinol (vitamin A) in the plasma. The protein consists
of a tetramer of identical subunits. More than 80 different
mutations in this gene have been reported; most mutations are
related to amyloid deposition, affecting predominantly peripheral
nerve and/or the heart, and a small portion of the gene mutations
is non-amyloidogenic. The diseases caused by mutations include
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia,
amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal
amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel
syndrome, etc. [provided by RefSeq, Jan 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BI549547.1, CD357987.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.