||ORF Nucleotide Sequence (Length: 444bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB498675.1, BC020791.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jan 22, 2009 this sequence version replaced gi:167736363.
Summary: This gene encodes transthyretin, one of the three
prealbumins including alpha-1-antitrypsin, transthyretin and
orosomucoid. Transthyretin is a carrier protein; it transports
thyroid hormones in the plasma and cerebrospinal fluid, and also
transports retinol (vitamin A) in the plasma. The protein consists
of a tetramer of identical subunits. More than 80 different
mutations in this gene have been reported; most mutations are
related to amyloid deposition, affecting predominantly peripheral
nerve and/or the heart, and a small portion of the gene mutations
is non-amyloidogenic. The diseases caused by mutations include
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia,
amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal
amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel
syndrome, etc. [provided by RefSeq, Jan 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BI549547.1, CD357987.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.