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UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) [Homo sapiens (human)]

Gene Symbol UCHL1
Entrez Gene ID 7345
Full Name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Synonyms HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
General protein information
Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
ubiquitin thioesterase L1
neuron cytoplasmic protein 9.5
ubiquitin C-terminal hydrolase
NP_004172.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p14

Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]. lac of sum
Disorder MIM:

191342

Disorder Html: {Parkinson disease 5, susceptibility to}, 613643 (3); {Parkinson
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu19475 NM_004181 Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu19475D
Sequence Information ORF Nucleotide Sequence (Length: 672bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ubiquitin carboxyl-terminal hydrolase isozyme L1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP202166.1 and BC000332.2. This sequence is a reference standard in the RefSeqGene project. On Jun 12, 2009 this sequence version replaced gi:34147658. Summary: The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000332.2, BC006305.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC
AAGGCAGCCTT AA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_004172.2
CDS97..768
Misc Feature(1)67..69(+)
Misc Feature(2)97..99(+)
Misc Feature(3)109..753(+)
Misc Feature(4)109..711(+)
Misc Feature(5)109..579(+)
Misc Feature(6)109..126(+)
Misc Feature(7)112..114(+)
Misc Feature(8)130..132(+)
Misc Feature(9)346..624(+)
Misc Feature(10)466..468(+)
Misc Feature(11)622..624(+)
Misc Feature(12)631..633(+)
Misc Feature(13)727..744(+)
Misc Feature(14)754..756(+)
Exon (1)1..129
Gene:UCHL1
Gene Synonym:
Exon (2)130..141
Gene:UCHL1
Gene Synonym:
Exon (3)142..270
Gene:UCHL1
Gene Synonym:
Exon (4)271..421
Gene:UCHL1
Gene Synonym:
Exon (5)422..507
Gene:UCHL1
Gene Synonym:
Exon (6)508..555
Gene:UCHL1
Gene Synonym:
Exon (7)556..622
Gene:UCHL1
Gene Synonym:
Exon (8)623..681
Gene:UCHL1
Gene Synonym:
Exon (9)682..1124
Gene:UCHL1
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:201100258
38 38 c, g dbSNP:577696101
43 43 a, c dbSNP:746517688
46 46 a, c, g dbSNP:371943957
47 47 c, g, t dbSNP:375794773
48 48 a, c dbSNP:775798907
49 49 a, c, g dbSNP:763516024
50 50 c, t dbSNP:752001613
53 53 g, t dbSNP:757358332
57 57 c, t dbSNP:767459303
59 59 a, g dbSNP:750684470
64 64 c, t dbSNP:756271669
65 65 c, g dbSNP:778811044
66 66 c, g dbSNP:747954734
69 69 a, c, g dbSNP:201952662
70 70 a, g dbSNP:777866474
71 71 a, c, t dbSNP:746877403
73 73 a, g dbSNP:11556271
74 74 a, t dbSNP:745572268
77 77 c, t dbSNP:769324047
79 79 a, g dbSNP:775888515
80 80 a, c, g, t dbSNP:367935445
81 81 c, t dbSNP:9321
82 82 c, g, t dbSNP:767689458
84 84 a, g dbSNP:756428586
85 85 c, t dbSNP:766696958
86 86 a, c, g, t dbSNP:200302762
89 89 c, t dbSNP:751596305
90 90 a, c dbSNP:757111252
94 94 a, g dbSNP:780819970
98 98 c, t dbSNP:745355343
102 102 a, g dbSNP:769288409
103 103 c, t dbSNP:779681524
111 111 a, g dbSNP:11556276
112 112 a, t dbSNP:201864413
116 116 a, c dbSNP:397515634
118 118 a, c dbSNP:769034726
121 121 a, g dbSNP:774679952
126 126 c, t dbSNP:762425804
130 130 a, g dbSNP:779319504
135 135 a, g dbSNP:748451000
149 149 a, c dbSNP:5030732
150 150 a, c dbSNP:745957339
151 151 a, c, t dbSNP:769924890
152 152 g, t dbSNP:763182177
153 153 c, g dbSNP:370928430
156 156 a, g, t dbSNP:767261015
161 161 g, t dbSNP:760676226
163 163 g, t dbSNP:766292262
165 165 c, t dbSNP:753720793
190 190 c, g dbSNP:754490470
195 195 g, t dbSNP:764766596
211 211 c, t dbSNP:752315512
216 216 c, g dbSNP:375032754
230 230 c, t dbSNP:758047620
234 234 c, g dbSNP:778064650
240 240 -, gct dbSNP:749368841
240 240 g, t dbSNP:548993481
244 244 c, t dbSNP:757635849
246 246 a, g dbSNP:781765426
255 255 c, t dbSNP:11556278
258 258 c, t dbSNP:746333982
259 259 c, g, t dbSNP:769782961
264 264 c, g dbSNP:749516843
276 276 c, g, t dbSNP:762527925
288 288 a, g dbSNP:751276790
295 295 a, c dbSNP:761532352
311 311 a, g dbSNP:189371541
319 319 a, g dbSNP:148096293
322 322 a, g dbSNP:747330895
332 332 c, t dbSNP:11556275
333 333 a, g dbSNP:756641317
339 339 c, t dbSNP:780627453
360 360 c, t dbSNP:111649115
362 362 c, t dbSNP:11556279
370 370 a, t dbSNP:754234212
375 375 c, g, t dbSNP:121917767
387 387 c, t dbSNP:192697162
388 388 a, g dbSNP:748417996
410 410 a, c dbSNP:772252224
441 441 -, ac dbSNP:761194133
443 443 a, t dbSNP:372479324
449 449 c, t dbSNP:11556274
452 452 c, t dbSNP:141828940
460 460 a, g dbSNP:754392787
466 466 a, c dbSNP:150601238
479 479 a, g dbSNP:376624356
481 481 a, c dbSNP:752770640
484 484 a, g dbSNP:758414333
493 493 c, t dbSNP:777973619
497 497 a, t dbSNP:747159120
499 499 a, c dbSNP:200775509
503 503 a, g dbSNP:139618482
510 510 c, t dbSNP:753134305
511 511 a, g dbSNP:758504465
519 519 a, g dbSNP:764111400
531 531 c, t dbSNP:142811772
532 532 a, g dbSNP:764784241
540 540 a, g dbSNP:147393026
546 546 c, t dbSNP:749021086
549 549 a, g dbSNP:557049900
551 551 c, g dbSNP:779001647
553 553 c, t dbSNP:139583787
554 554 c, g dbSNP:771734476
565 565 a, g dbSNP:758378913
567 567 a, g dbSNP:777409628
575 575 a, t dbSNP:746488910
576 576 c, t dbSNP:146069195
582 582 c, t dbSNP:770405812
589 589 c, t dbSNP:564599222
597 597 c, t dbSNP:745473963
598 598 a, g dbSNP:770192031
609 609 c, t dbSNP:145093131
612 612 c, t dbSNP:763513865
614 614 a, g dbSNP:769027517
615 615 c, t dbSNP:374340108
629 629 a, g dbSNP:768996179
638 638 c, t dbSNP:774754812
641 641 c, t dbSNP:748642283
642 642 g, t dbSNP:772097475
654 654 c, t dbSNP:116680633
655 655 a, g dbSNP:761045481
658 658 a, g dbSNP:766696874
672 672 c, g, t dbSNP:776936367
685 685 g, t dbSNP:767451697
688 688 a, g dbSNP:750290755
693 693 c, g dbSNP:755650397
697 697 a, t dbSNP:765829058
705 705 a, g dbSNP:147661219
711 711 c, t dbSNP:375527220
712 712 a, g dbSNP:779215950
723 723 -, agg dbSNP:754277320
723 723 a, g dbSNP:540101531
726 726 a, g dbSNP:753093031
729 729 a, g dbSNP:758779751
730 730 c, g dbSNP:778431309
733 733 c, t dbSNP:747468259
738 738 c, t dbSNP:539670990
744 744 a, c, t dbSNP:781389075
745 745 a, g dbSNP:770039881
760 760 a, g dbSNP:112666846
770 770 a, g dbSNP:775513694
781 781 a, g dbSNP:370431599
785 785 c, g dbSNP:369814359
788 788 c, t dbSNP:77194345
789 789 a, g dbSNP:773158014
812 812 a, g dbSNP:760586461
814 814 a, g dbSNP:765917631
826 826 -, c dbSNP:760542056
828 828 c, t dbSNP:753389158
831 831 a, c, g dbSNP:759170558
834 834 a, t dbSNP:752225914
835 835 c, t dbSNP:758867690
837 837 c, g dbSNP:778259499
838 838 -, a dbSNP:768753947
840 840 -, c dbSNP:776684041
846 846 a, g dbSNP:553172248
899 899 c, t dbSNP:183586019
945 945 gc, tg dbSNP:386673866
995 995 c, g dbSNP:535206351
997 997 g, t dbSNP:555393576
1002 1002 g, t dbSNP:115323706
1008 1008 g, t dbSNP:11556270
1013 1013 c, t dbSNP:140683078
1018 1018 c, t dbSNP:564857603
1044 1044 a, t dbSNP:116336893
1052 1052 g, t dbSNP:540507296
1054 1054 c, t dbSNP:560407112
1062 1062 a, g dbSNP:116700032
1077 1077 c, t dbSNP:78683791
1098 1098 a, g dbSNP:755024590
1122 1122 a, g dbSNP:369393584

Target ORF information:

RefSeq Version NM_004181
Organism Homo sapiens (human)
Definition Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_004181

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC
AAGGCAGCCTT AA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.