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VPREB1 pre-B lymphocyte 1 [Homo sapiens (human)]

Gene Symbol VPREB1
Entrez Gene ID 7441
Full Name pre-B lymphocyte 1
Synonyms CD179a, IGI, IGVPB, VPREB
General protein information
Preferred Names
immunoglobulin iota chain
Names
immunoglobulin iota chain
CD179a
v(pre)B protein
CD179 antigen-like family member A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q11.22

Summary The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. lac of sum
Disorder MIM:

605141

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu18799 NM_007128 Homo sapiens pre-B lymphocyte 1 (VPREB1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu61315 NM_001303509 Homo sapiens pre-B lymphocyte 1 (VPREB1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu18799D
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product immunoglobulin iota chain isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG502270.1, BC017922.1 and AC245060.1. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2015 this sequence version replaced gi:18379350. Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG531255.1, BC017922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC
AGGACACGTG TCCCTTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_009059.1
CDS35..472
Misc Feature(1)10..10(+)
Misc Feature(2)92..157(+)
Misc Feature(3)110..382(+)
Misc Feature(4)122..388(+)
Misc Feature(5)158..202(+)
Misc Feature(6)203..244(+)
Misc Feature(7)245..277(+)
Misc Feature(8)278..379(+)
Exon (1)1..80
Gene:VPREB1
Gene Synonym:
Exon (2)81..650
Gene:VPREB1
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:748130554
5 5 a, g dbSNP:772110612
24 24 at, gc dbSNP:35044569
24 24 a, g dbSNP:11089977
25 25 c, t dbSNP:11089978
37 37 a, g dbSNP:770675216
40 40 c, g, t dbSNP:776159728
45 45 c, t dbSNP:764756028
47 47 c, g dbSNP:146019843
59 59 a, g dbSNP:763501525
68 68 a, g dbSNP:369078606
74 74 c, t dbSNP:764478096
76 76 a, c, t dbSNP:752028134
88 88 g, t dbSNP:751480887
91 91 a, t dbSNP:368615340
96 96 c, t dbSNP:372350881
97 97 a, g dbSNP:555986282
98 98 a, g dbSNP:575961028
101 101 c, g dbSNP:201722357
103 103 a, g dbSNP:9619852
111 111 c, t dbSNP:375221058
112 112 a, g dbSNP:773875100
114 114 c, t dbSNP:142180774
115 115 a, g dbSNP:772598196
116 116 c, g dbSNP:779190018
117 117 a, c, g dbSNP:773777992
118 118 c, t dbSNP:766788694
119 119 a, g dbSNP:151193387
121 121 a, g dbSNP:759763171
122 122 c, t dbSNP:765252661
123 123 c, t dbSNP:199900999
127 127 a, g dbSNP:201207008
146 146 c, t dbSNP:369071851
147 147 a, c, g dbSNP:139951133
157 157 c, t dbSNP:779761070
163 163 a, g dbSNP:748929156
169 169 c, t dbSNP:754613086
170 170 a, g, t dbSNP:373127258
173 173 c, g dbSNP:772511236
178 178 a, c dbSNP:773865986
179 179 a, g dbSNP:747453326
181 181 c, t dbSNP:200837518
182 182 a, g dbSNP:569269303
184 184 c, t dbSNP:369971197
185 185 g, t dbSNP:759724647
189 189 a, g dbSNP:765468390
190 190 c, t dbSNP:775501387
194 194 a, g dbSNP:763074545
198 198 a, c dbSNP:367626273
216 216 c, t dbSNP:764103880
217 217 a, c, g, t dbSNP:531716932
220 220 c, t dbSNP:548324194
225 225 c, g dbSNP:375144762
245 245 c, t dbSNP:778612621
247 247 c, t dbSNP:747694053
252 252 c, t dbSNP:757983199
258 258 c, g dbSNP:777378025
260 260 a, g dbSNP:1320
264 264 a, g, t dbSNP:147568280
271 271 c, g dbSNP:371374519
272 272 a, g, t dbSNP:62640870
273 273 a, g dbSNP:144188550
278 278 c, t dbSNP:763020090
282 282 -, c dbSNP:777891394
282 282 g, t dbSNP:764194298
283 283 c, g dbSNP:145423292
286 286 c, g dbSNP:760657740
287 287 c, t dbSNP:766275818
290 290 c, t dbSNP:753630669
291 291 a, g dbSNP:149218137
294 294 c, t dbSNP:374140532
297 297 a, c dbSNP:752424548
308 308 a, g dbSNP:200057782
315 315 c, t dbSNP:777471890
318 318 a, g dbSNP:751080779
323 323 -, ag dbSNP:747158083
325 325 c, g, t dbSNP:188917401
326 326 a, g dbSNP:746302877
327 327 g, t dbSNP:770199352
330 330 a, g, t dbSNP:143361893
335 335 a, t dbSNP:760542180
339 339 a, t dbSNP:201276189
340 340 c, t dbSNP:373510626
343 343 c, t dbSNP:148339904
350 350 c, t dbSNP:17851581
361 361 c, t dbSNP:377536245
370 370 a, g dbSNP:140610553
378 378 a, g dbSNP:370863274
379 379 c, t dbSNP:765101837
384 384 c, t dbSNP:752409950
387 387 g, t dbSNP:762733699
389 389 g, t dbSNP:111340500
390 390 a, c dbSNP:751172832
392 392 c, t dbSNP:201713481
393 393 a, g dbSNP:200943449
397 397 c, t dbSNP:5995719
399 399 c, t dbSNP:11089979
400 400 a, g dbSNP:368680329
403 403 g, t dbSNP:749626116
405 405 -, agg dbSNP:756014624
409 409 a, g dbSNP:371684716
419 419 a, c dbSNP:779116797
420 420 a, g dbSNP:748299022
424 424 a, g dbSNP:564394873
428 428 a, g dbSNP:5995720
437 437 a, g dbSNP:200309974
438 438 c, t dbSNP:769587854
447 447 c, g dbSNP:775421278
458 458 a, t dbSNP:374994226
461 461 c, t dbSNP:367915074
462 462 a, g dbSNP:751262788
466 466 c, g dbSNP:761519628
469 469 c, t dbSNP:371960617
471 471 a, g dbSNP:62640867
475 475 a, t dbSNP:371987770
487 487 a, g dbSNP:6001563
488 488 a, g dbSNP:765590760
492 492 c, g dbSNP:766795867
493 493 a, g dbSNP:754282074
498 498 c, t dbSNP:185445944
517 517 a, g dbSNP:113585988
528 528 a, g dbSNP:750943572
531 531 c, t dbSNP:2285019
535 535 c, t dbSNP:547653598
536 536 a, g dbSNP:571106781
545 545 a, g dbSNP:570823541
547 547 c, t dbSNP:530631007
548 548 a, g dbSNP:140258192
611 611 -, c dbSNP:746870842
641 641 c, t dbSNP:190303299

Target ORF information:

RefSeq Version NM_007128
Organism Homo sapiens (human)
Definition Homo sapiens pre-B lymphocyte 1 (VPREB1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_007128

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu61315D
Sequence Information ORF Nucleotide Sequence (Length: 435bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-MAY-2015
Organism Homo sapiens (human)
Product immunoglobulin iota chain isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245060.1. Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG502270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG
ACACGTGTCC CTTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001290438.1
CDS24..458
Misc Feature(1)10..10(+)
Misc Feature(2)96..368(+)
Misc Feature(3)108..374(+)
Exon (1)1..80
Gene:VPREB1
Gene Synonym:
Exon (2)81..636
Gene:VPREB1
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:748130554
5 5 a, g dbSNP:772110612
24 24 at, gc dbSNP:35044569
24 24 a, g dbSNP:11089977
25 25 c, t dbSNP:11089978
37 37 a, g dbSNP:770675216
40 40 c, g, t dbSNP:776159728
45 45 c, t dbSNP:764756028
47 47 c, g dbSNP:146019843
59 59 a, g dbSNP:763501525
68 68 a, g dbSNP:369078606
74 74 c, t dbSNP:764478096
76 76 a, c, t dbSNP:752028134
82 82 c, t dbSNP:372350881
83 83 a, g dbSNP:555986282
84 84 a, g dbSNP:575961028
87 87 c, g dbSNP:201722357
89 89 a, g dbSNP:9619852
97 97 c, t dbSNP:375221058
98 98 a, g dbSNP:773875100
100 100 c, t dbSNP:142180774
101 101 a, g dbSNP:772598196
102 102 c, g dbSNP:779190018
103 103 a, c, g dbSNP:773777992
104 104 c, t dbSNP:766788694
105 105 a, g dbSNP:151193387
107 107 a, g dbSNP:759763171
108 108 c, t dbSNP:765252661
109 109 c, t dbSNP:199900999
113 113 a, g dbSNP:201207008
132 132 c, t dbSNP:369071851
133 133 a, c, g dbSNP:139951133
143 143 c, t dbSNP:779761070
149 149 a, g dbSNP:748929156
155 155 c, t dbSNP:754613086
156 156 a, g, t dbSNP:373127258
159 159 c, g dbSNP:772511236
164 164 a, c dbSNP:773865986
165 165 a, g dbSNP:747453326
167 167 c, t dbSNP:200837518
168 168 a, g dbSNP:569269303
170 170 c, t dbSNP:369971197
171 171 g, t dbSNP:759724647
175 175 a, g dbSNP:765468390
176 176 c, t dbSNP:775501387
180 180 a, g dbSNP:763074545
184 184 a, c dbSNP:367626273
202 202 c, t dbSNP:764103880
203 203 a, c, g, t dbSNP:531716932
206 206 c, t dbSNP:548324194
211 211 c, g dbSNP:375144762
231 231 c, t dbSNP:778612621
233 233 c, t dbSNP:747694053
238 238 c, t dbSNP:757983199
244 244 c, g dbSNP:777378025
246 246 a, g dbSNP:1320
250 250 a, g, t dbSNP:147568280
257 257 c, g dbSNP:371374519
258 258 a, g, t dbSNP:62640870
259 259 a, g dbSNP:144188550
264 264 c, t dbSNP:763020090
268 268 -, c dbSNP:777891394
268 268 g, t dbSNP:764194298
269 269 c, g dbSNP:145423292
272 272 c, g dbSNP:760657740
273 273 c, t dbSNP:766275818
276 276 c, t dbSNP:753630669
277 277 a, g dbSNP:149218137
280 280 c, t dbSNP:374140532
283 283 a, c dbSNP:752424548
294 294 a, g dbSNP:200057782
301 301 c, t dbSNP:777471890
304 304 a, g dbSNP:751080779
309 309 -, ag dbSNP:747158083
311 311 c, g, t dbSNP:188917401
312 312 a, g dbSNP:746302877
313 313 g, t dbSNP:770199352
316 316 a, g, t dbSNP:143361893
321 321 a, t dbSNP:760542180
325 325 a, t dbSNP:201276189
326 326 c, t dbSNP:373510626
329 329 c, t dbSNP:148339904
336 336 c, t dbSNP:17851581
347 347 c, t dbSNP:377536245
356 356 a, g dbSNP:140610553
364 364 a, g dbSNP:370863274
365 365 c, t dbSNP:765101837
370 370 c, t dbSNP:752409950
373 373 g, t dbSNP:762733699
375 375 g, t dbSNP:111340500
376 376 a, c dbSNP:751172832
378 378 c, t dbSNP:201713481
379 379 a, g dbSNP:200943449
383 383 c, t dbSNP:5995719
385 385 c, t dbSNP:11089979
386 386 a, g dbSNP:368680329
389 389 g, t dbSNP:749626116
391 391 -, agg dbSNP:756014624
395 395 a, g dbSNP:371684716
405 405 a, c dbSNP:779116797
406 406 a, g dbSNP:748299022
410 410 a, g dbSNP:564394873
414 414 a, g dbSNP:5995720
423 423 a, g dbSNP:200309974
424 424 c, t dbSNP:769587854
433 433 c, g dbSNP:775421278
444 444 a, t dbSNP:374994226
447 447 c, t dbSNP:367915074
448 448 a, g dbSNP:751262788
452 452 c, g dbSNP:761519628
455 455 c, t dbSNP:371960617
457 457 a, g dbSNP:62640867
461 461 a, t dbSNP:371987770
473 473 a, g dbSNP:6001563
474 474 a, g dbSNP:765590760
478 478 c, g dbSNP:766795867
479 479 a, g dbSNP:754282074
484 484 c, t dbSNP:185445944
503 503 a, g dbSNP:113585988
514 514 a, g dbSNP:750943572
517 517 c, t dbSNP:2285019
521 521 c, t dbSNP:547653598
522 522 a, g dbSNP:571106781
531 531 a, g dbSNP:570823541
533 533 c, t dbSNP:530631007
534 534 a, g dbSNP:140258192
597 597 -, c dbSNP:746870842
627 627 c, t dbSNP:190303299

Target ORF information:

RefSeq Version NM_001303509
Organism Homo sapiens (human)
Definition Homo sapiens pre-B lymphocyte 1 (VPREB1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001303509

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.