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WRN Werner syndrome, RecQ helicase-like [Homo sapiens (human)]

Gene Symbol WRN
Entrez Gene ID 7486
Full Name Werner syndrome, RecQ helicase-like
Synonyms RECQ3, RECQL2, RECQL3
General protein information
Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome ATP-dependent helicase
exonuclease WRN
recQ protein-like 2
DNA helicase, RecQ-like type 3
NP_000544.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12

Summary This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604611

Disorder Html: Werner syndrome, 277700 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu61339 XM_011544639 PREDICTED: Homo sapiens Werner syndrome, RecQ helicase-like (WRN), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 25 Starting from $99.00
OHu61340 XM_011544640 PREDICTED: Homo sapiens Werner syndrome, RecQ helicase-like (WRN), transcript variant X5, mRNA. pcDNA3.1-C-(k)DYK Not in stock 12-14 Starting from $99.00
OHu18809 NM_000553 Homo sapiens Werner syndrome, RecQ helicase-like (WRN), mRNA. pcDNA3.1-C-(k)DYK Not in stock -1 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu61339D
Sequence Information ORF Nucleotide Sequence (Length: 4218bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product Werner syndrome ATP-dependent helicase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167187.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG
GGAGGTCTTT TTAGTTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_011542941.1
CDS273..4490
Misc Feature(1)453..959(+)
Misc Feature(2)516..920(+)
Misc Feature(3)516..920(+)
Misc Feature(4)519..920(+)
Misc Feature(5)1803..3221(+)
Misc Feature(6)1884..2306(+)
Misc Feature(7)1911..1925(+)
Misc Feature(8)2193..2204(+)
Misc Feature(9)2466..2792(+)
Misc Feature(10)2505..2660(+)
Misc Feature(11)2676..2762(+)
Misc Feature(12)3063..3344(+)
Misc Feature(13)3657..3878(+)
Misc Feature(14)3960..4247(+)
Translation
Position Chain Variation Link
9 9 g, t dbSNP:369873912
31 31 a, t dbSNP:566565869
60 60 a, g dbSNP:11574158
73 73 c, t dbSNP:778938665
76 76 a, c, t dbSNP:11574159
85 85 a, g dbSNP:753342861
94 94 c, t dbSNP:754522897
110 110 c, g dbSNP:11574160
129 129 g, t dbSNP:537618726
189 189 c, t dbSNP:188087758
222 222 c, t dbSNP:187869929
225 225 c, t dbSNP:193031348
227 227 c, g dbSNP:774377745
236 236 a, g dbSNP:370014019
247 247 a, g dbSNP:763753170
249 249 c, t dbSNP:753595348
280 280 -, a dbSNP:745681892
284 284 a, g dbSNP:761784221
288 288 a, c, t dbSNP:202148988
297 297 a, g dbSNP:757791580
305 305 a, g dbSNP:756255418
309 309 c, t dbSNP:373503267
314 314 a, g dbSNP:3087420
345 345 a, g dbSNP:754627643
346 346 g, t dbSNP:781459943
347 347 a, g dbSNP:150524008
349 349 a, g dbSNP:550926459
351 351 a, g dbSNP:778355874
354 354 a, g dbSNP:538314935
367 367 a, g dbSNP:34477820
368 368 -, g dbSNP:755891046
371 371 a, g dbSNP:753114305
376 376 c, t dbSNP:538178496
378 378 c, t dbSNP:141495269
379 379 a, g dbSNP:34084741
383 383 c, g dbSNP:771433734
386 386 c, t dbSNP:201800431
401 401 c, t dbSNP:201590676
402 402 c, g dbSNP:139775895
407 407 -, ctt dbSNP:768226589
409 409 c, t dbSNP:772246871
415 415 a, g dbSNP:775635001
416 416 a, g dbSNP:145959045
417 417 a, t dbSNP:587778749
429 429 a, g dbSNP:772963859
432 432 a, g dbSNP:762851957
443 443 c, t dbSNP:373806031
444 444 a, g dbSNP:773803207
448 448 c, t dbSNP:759022881
450 450 a, g dbSNP:767288688
454 454 a, g dbSNP:752345825
469 469 c, t dbSNP:756575284
473 473 a, g dbSNP:764589321
491 491 a, g dbSNP:566693857
497 497 -, g dbSNP:747587698
501 501 c, g dbSNP:144670883
513 513 c, t dbSNP:760452488
531 531 -, c dbSNP:773717744
542 542 c, t dbSNP:148758902
548 548 a, g dbSNP:754221635
561 561 a, g dbSNP:757573403
575 575 a, g dbSNP:765687541
576 576 c, t dbSNP:750903457
585 585 -, tc dbSNP:760991758
587 587 c, t dbSNP:758873256
594 594 a, c dbSNP:780157148
598 598 a, g dbSNP:142346721
599 599 c, g, t dbSNP:371538747
600 600 -, a dbSNP:766733097
602 602 c, t dbSNP:749053792
611 611 c, t dbSNP:374898432
612 612 a, g dbSNP:2230009
621 621 a, g dbSNP:768216398
622 622 c, t dbSNP:772108759
634 634 c, g dbSNP:768174465
635 635 c, g dbSNP:372942234
645 645 a, g dbSNP:267607007
647 647 a, t dbSNP:387906337
675 675 a, g dbSNP:267607008
678 678 a, g dbSNP:17847582
692 692 g, t dbSNP:548061402
693 693 a, g dbSNP:769317785
701 701 c, t dbSNP:773697397
703 703 a, g dbSNP:771444804
704 704 a, g dbSNP:766887542
708 708 a, c, g dbSNP:752014453
714 714 c, g dbSNP:767673195
715 715 a, t dbSNP:587778753
717 717 c, t dbSNP:752693894
718 718 a, c, g dbSNP:61761625
724 724 a, t dbSNP:200456571
738 738 a, c, g dbSNP:758208189
744 744 c, t dbSNP:746985833
757 757 c, t dbSNP:147661728
758 758 a, g dbSNP:141480904
759 759 g, t dbSNP:368717487
760 760 a, t dbSNP:769495252
769 769 a, g dbSNP:772797243
771 771 -, aa dbSNP:776785728
771 771 a, g dbSNP:749679346
785 785 c, t dbSNP:1800389
786 786 a, c dbSNP:367991517
787 787 a, c dbSNP:777437332
796 796 -, g dbSNP:752830087
799 799 g, t dbSNP:748976035
808 808 a, g dbSNP:770545798
814 814 c, t dbSNP:774751582
820 820 a, g dbSNP:746210769
821 821 c, t dbSNP:772637078
833 833 a, g dbSNP:775802030
847 847 a, g dbSNP:760829035
848 848 c, g dbSNP:771397499
851 851 a, g dbSNP:764227749
853 853 c, t dbSNP:776831463
855 855 a, g dbSNP:371736282
858 858 c, t dbSNP:375762379
859 859 a, g dbSNP:561603992
860 860 a, c dbSNP:759197788
873 873 a, g dbSNP:767516095
882 882 c, t dbSNP:199644081
885 885 c, g dbSNP:756050193
891 891 c, g dbSNP:777311042
898 898 a, g dbSNP:753330899
900 900 a, c dbSNP:138037385
907 907 a, g dbSNP:756966886
913 913 c, g dbSNP:778470570
917 917 a, t dbSNP:746256937
918 918 c, g dbSNP:772273549
925 925 a, g dbSNP:780640173
926 926 c, t dbSNP:747520883
932 932 g, t dbSNP:756697581
936 936 a, t dbSNP:201902936
938 938 c, t dbSNP:376622928
939 939 a, g, t dbSNP:587778754
945 945 c, t dbSNP:370324188
946 946 a, g dbSNP:62506077
948 948 a, c dbSNP:143088402
972 972 c, g dbSNP:769291583
987 987 a, g dbSNP:781741859
992 992 g, t dbSNP:148229804
996 996 a, c, g dbSNP:769959338
1010 1010 a, c dbSNP:141615988
1016 1016 c, t dbSNP:370071444
1017 1017 a, g dbSNP:758055295
1019 1019 a, c dbSNP:374142752
1020 1020 a, g dbSNP:767793936
1026 1026 a, c dbSNP:751986285
1052 1052 a, g dbSNP:776183892
1056 1056 a, g dbSNP:781773383
1061 1061 c, t dbSNP:748707126
1068 1068 a, g dbSNP:756669569
1081 1081 a, c dbSNP:777770937
1102 1102 a, c dbSNP:749379604
1106 1106 a, g, t dbSNP:527842476
1107 1107 c, t dbSNP:199923241
1108 1108 a, g dbSNP:768400363
1109 1109 c, g dbSNP:113672137
1111 1111 c, g dbSNP:761786255
1118 1118 c, t dbSNP:772258462
1119 1119 a, g dbSNP:201643901
1122 1122 g, t dbSNP:747871633
1123 1123 c, t dbSNP:769634887
1124 1124 a, g dbSNP:146197312
1127 1127 a, g dbSNP:762404436
1132 1132 a, g dbSNP:770517898
1134 1134 a, g dbSNP:773980642
1137 1137 -, tcagaaaa dbSNP:752312589
1148 1148 a, g dbSNP:759323644
1152 1152 a, t dbSNP:376219460
1156 1156 c, t dbSNP:767270343
1165 1165 c, t dbSNP:753112277
1167 1167 -, t dbSNP:757968518
1168 1168 c, t dbSNP:761040399
1175 1175 a, g dbSNP:747226837
1177 1177 c, t dbSNP:754329517
1184 1184 -, c dbSNP:777323239
1193 1193 -, tg dbSNP:746445847
1214 1214 c, t dbSNP:757672816
1221 1221 -, tta dbSNP:771474603
1233 1233 g, t dbSNP:779012596
1240 1240 c, t dbSNP:369277330
1242 1242 a, g dbSNP:1800390
1249 1249 a, g dbSNP:143068173
1256 1256 a, g dbSNP:201979783
1258 1258 a, c, g dbSNP:4987237
1263 1263 a, g dbSNP:777402254
1270 1270 g, t dbSNP:530437272
1277 1277 a, t dbSNP:770764781
1279 1279 a, g dbSNP:774075901
1284 1284 a, g dbSNP:759046519
1290 1290 a, g dbSNP:771859604
1292 1292 a, t dbSNP:775231592
1295 1295 c, t dbSNP:760975157
1296 1296 a, g dbSNP:764559021
1297 1297 c, t dbSNP:181033722
1299 1299 a, g dbSNP:11574222
1318 1318 c, t dbSNP:765667470
1339 1339 a, g dbSNP:556227294
1342 1342 a, g dbSNP:372907716
1345 1345 a, g dbSNP:780287000
1353 1353 g, t dbSNP:751850825
1356 1356 a, g dbSNP:755136292
1358 1358 a, g dbSNP:777685918
1365 1365 a, c dbSNP:749035826
1372 1372 c, t dbSNP:576284026
1377 1377 c, t dbSNP:17847577
1390 1390 g, t dbSNP:376913063
1393 1393 -, ttc dbSNP:781511385
1395 1395 c, g dbSNP:745391184
1417 1417 a, g dbSNP:541455377
1421 1421 g, t dbSNP:4987238
1427 1427 a, g dbSNP:2230010
1427 1427 a, g dbSNP:386561765
1431 1431 a, g dbSNP:370136100
1433 1433 a, g dbSNP:1800391
1435 1435 -, a dbSNP:558267186
1439 1439 a, c dbSNP:762026460
1444 1444 g, t dbSNP:145445994
1446 1446 a, t dbSNP:773671411
1452 1452 c, t dbSNP:75632545
1453 1453 c, g, t dbSNP:200487813
1454 1454 a, g dbSNP:138565529
1459 1459 a, g dbSNP:755298910
1461 1461 a, g dbSNP:767571801
1464 1464 a, g dbSNP:532554615
1469 1469 a, c dbSNP:748158243
1471 1471 a, g dbSNP:757065467
1476 1476 c, g dbSNP:779022285
1478 1478 c, t dbSNP:745838198
1493 1493 a, g dbSNP:758386387
1494 1494 a, c dbSNP:779671852
1508 1508 a, g dbSNP:746496708
1512 1512 c, g dbSNP:587778755
1519 1519 a, g dbSNP:560922465
1528 1528 a, c dbSNP:776098344
1532 1532 a, g dbSNP:748544713
1536 1536 a, c dbSNP:770185829
1539 1539 a, g dbSNP:773546749
1547 1547 a, g dbSNP:771486771
1555 1555 a, g dbSNP:774668851
1560 1560 a, g dbSNP:573775829
1568 1568 c, t dbSNP:772082980
1570 1570 a, g dbSNP:775685980
1573 1573 c, t dbSNP:761035278
1574 1574 a, g dbSNP:374140086
1576 1576 c, t dbSNP:750246326
1581 1581 a, g dbSNP:562250010
1596 1596 a, g dbSNP:147669987
1600 1600 a, t dbSNP:751493081
1611 1611 a, g dbSNP:754922905
1613 1613 a, g dbSNP:200380997
1623 1623 c, t dbSNP:745685947
1626 1626 c, t dbSNP:545516221
1630 1630 a, t dbSNP:775240079
1634 1634 c, t dbSNP:760660037
1639 1639 a, g dbSNP:764011979
1642 1642 g, t dbSNP:776008000
1648 1648 c, t dbSNP:761328537
1649 1649 c, g dbSNP:764818941
1657 1657 c, t dbSNP:750052448
1659 1659 a, t dbSNP:758101797
1666 1666 c, t dbSNP:766910166
1676 1676 -, aaaa dbSNP:751112452
1677 1677 a, t dbSNP:751969803
1695 1695 c, g dbSNP:755548890
1696 1696 g, t dbSNP:201172985
1698 1698 c, t dbSNP:752745117
1700 1700 c, t dbSNP:756183348
1704 1704 a, c dbSNP:777679266
1705 1705 c, t dbSNP:749569654
1708 1708 -, aagaag dbSNP:781777438
1708 1708 -, aag dbSNP:555283914
1718 1718 a, c dbSNP:771126045
1720 1720 a, g dbSNP:113811718
1721 1721 -, gat dbSNP:746348167
1721 1721 a, g, t dbSNP:149565907
1722 1722 c, g, t dbSNP:368413625
1723 1723 a, g dbSNP:761259830
1724 1724 a, t dbSNP:531326550
1726 1726 a, t dbSNP:763266496
1728 1728 c, g dbSNP:772584887
1734 1734 c, g dbSNP:376345065
1754 1754 a, c dbSNP:747825738
1757 1757 g, t dbSNP:751988233
1759 1759 -, a dbSNP:770352933
1761 1761 a, g dbSNP:759933355
1769 1769 -, c dbSNP:780555196
1773 1773 a, c, t dbSNP:752994352
1778 1778 a, g dbSNP:369741345
1785 1785 c, t dbSNP:764445113
1789 1789 c, t dbSNP:11574240
1790 1790 c, t dbSNP:757279675
1795 1795 a, t dbSNP:765475534
1799 1799 a, g dbSNP:540506828
1809 1809 c, t dbSNP:750684158
1819 1819 a, c dbSNP:151001436
1843 1843 c, t dbSNP:781107893
1860 1860 -, attc dbSNP:749616545
1865 1865 c, t dbSNP:750496781
1888 1888 a, t dbSNP:758649710
1889 1889 c, t dbSNP:571962311
1895 1895 c, t dbSNP:140875989
1896 1896 g, t dbSNP:755823012
1899 1899 c, g dbSNP:587778746
1901 1901 c, g, t dbSNP:370664707
1905 1905 c, g dbSNP:778636025
1906 1906 c, t dbSNP:745310541
1908 1908 a, g dbSNP:150148567
1910 1910 g, t dbSNP:145564947
1915 1915 a, g dbSNP:757269649
1916 1916 c, t dbSNP:13438802
1921 1921 a, t dbSNP:121908448
1931 1931 c, t dbSNP:749974657
1935 1935 c, t dbSNP:757808169
1944 1944 c, t dbSNP:554671327
1947 1947 c, g dbSNP:746690931
1951 1951 a, t dbSNP:137977751
1952 1952 c, t dbSNP:372635306
1953 1953 a, g dbSNP:587778747
1959 1959 a, t dbSNP:770306531
1967 1967 a, c dbSNP:773549958
1974 1974 a, t dbSNP:763482212
1977 1977 c, t dbSNP:374514457
1979 1979 c, t dbSNP:13438803
1986 1986 a, g dbSNP:368931681
1997 1997 c, g dbSNP:201586173
2004 2004 c, g dbSNP:753701726
2005 2005 a, g dbSNP:761654576
2009 2009 a, g dbSNP:765298638
2012 2012 a, g dbSNP:750369623
2015 2015 a, g dbSNP:758335587
2017 2017 a, t dbSNP:779488238
2022 2022 a, g dbSNP:762866297
2024 2024 a, g dbSNP:766281234
2026 2026 c, g dbSNP:11574250
2029 2029 a, g dbSNP:754443271
2031 2031 a, g dbSNP:577000913
2041 2041 g, t dbSNP:752392526
2044 2044 g, t dbSNP:755746575
2070 2070 a, g dbSNP:374688634
2073 2073 c, g dbSNP:77969734
2077 2077 c, t dbSNP:757722268
2080 2080 a, g dbSNP:779430282
2085 2085 a, g dbSNP:745979339
2092 2092 a, c, g dbSNP:759533715
2094 2094 a, g dbSNP:774998815
2098 2098 a, g dbSNP:569266355
2100 2100 a, c, t dbSNP:148286708
2108 2108 a, g dbSNP:200291937
2111 2111 c, t dbSNP:765756226
2112 2112 a, g dbSNP:572026265
2123 2123 a, g dbSNP:758979216
2133 2133 c, g dbSNP:780657433
2144 2144 c, t dbSNP:11574263
2148 2148 c, g dbSNP:373177461
2149 2149 c, t dbSNP:781109286
2155 2155 a, t dbSNP:376938452
2166 2166 a, g dbSNP:769901163
2173 2173 g, t dbSNP:755426500
2175 2175 a, g dbSNP:781397548
2178 2178 a, t dbSNP:754509612
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2180 2180 a, g, t dbSNP:201982706
2184 2184 a, g dbSNP:754104065
2190 2190 a, g, t dbSNP:748097536
2195 2195 c, t dbSNP:575593855
2198 2198 a, g dbSNP:745697860
2214 2214 c, g dbSNP:758232075
2218 2218 a, g dbSNP:779805817
2220 2220 a, g dbSNP:747026081
2221 2221 a, g dbSNP:543878821
2222 2222 a, g dbSNP:776209945
2224 2224 a, g dbSNP:747555501
2226 2226 a, g dbSNP:769600792
2243 2243 c, t dbSNP:148385320
2248 2248 a, g dbSNP:370522829
2250 2250 g, t dbSNP:185468906
2258 2258 c, t dbSNP:191757062
2269 2269 c, g, t dbSNP:760090174
2274 2274 c, t dbSNP:752841355
2277 2277 a, g dbSNP:756149876
2282 2282 a, t dbSNP:781016211
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2286 2286 a, g dbSNP:756115593
2288 2288 c, t dbSNP:777423206
2295 2295 c, t dbSNP:748745844
2299 2299 c, g, t dbSNP:201384942
2303 2303 c, t dbSNP:745506503
2305 2305 c, t dbSNP:141563618
2307 2307 g, t dbSNP:775913837
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2310 2310 a, c, g dbSNP:761240520
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2319 2319 a, g dbSNP:180814740
2322 2322 c, t dbSNP:34560788
2323 2323 a, c, g dbSNP:750658657
2329 2329 a, g dbSNP:767281534
2331 2331 a, g dbSNP:752472638
2333 2333 c, t dbSNP:756129972
2337 2337 c, t dbSNP:201990558
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2359 2359 a, c dbSNP:778467522
2362 2362 a, g dbSNP:372795551
2366 2366 c, t dbSNP:771754762
2370 2370 -, t dbSNP:281865158
2376 2376 a, g dbSNP:558054655
2383 2383 a, t dbSNP:747317429
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2386 2386 a, g dbSNP:777084325
2392 2392 a, g dbSNP:762358256
2398 2398 a, g dbSNP:769819743
2406 2406 a, g dbSNP:773337566
2412 2412 c, t dbSNP:763089663
2413 2413 a, g dbSNP:766561388
2416 2416 a, c dbSNP:374156628
2422 2422 a, g dbSNP:368402409
2424 2424 a, g dbSNP:763947488
2425 2425 a, c dbSNP:753878041
2428 2428 g, t dbSNP:757207256
2429 2429 a, c dbSNP:764724926
2430 2430 c, g dbSNP:749885093
2432 2432 g, t dbSNP:2230011
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2454 2454 a, g dbSNP:769448856
2464 2464 a, g dbSNP:748667880
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2488 2488 c, g dbSNP:748486712
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2491 2491 c, g, t dbSNP:201282577
2493 2493 a, g dbSNP:771180836
2498 2498 c, t dbSNP:538573677
2503 2503 c, g dbSNP:746161973
2506 2506 c, t dbSNP:140730934
2519 2519 a, g, t dbSNP:555281600
2522 2522 a, g dbSNP:375863936
2529 2529 a, g dbSNP:574787451
2533 2533 c, t dbSNP:17847568
2544 2544 a, c dbSNP:765938062
2546 2546 a, g dbSNP:751002549
2552 2552 g, t dbSNP:1800392
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2561 2561 a, c, t dbSNP:753030891
2562 2562 g, t dbSNP:200169079
2563 2563 a, g dbSNP:754423621
2564 2564 c, t dbSNP:757837913
2578 2578 c, t dbSNP:779140898
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2602 2602 a, g dbSNP:145698720
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2607 2607 a, g dbSNP:200935416
2613 2613 c, t dbSNP:369776725
2614 2614 a, g dbSNP:377012608
2630 2630 a, t dbSNP:182891206
2638 2638 a, g dbSNP:762881466
2641 2641 c, g dbSNP:774308552
2651 2651 c, g, t dbSNP:1800393
2654 2654 c, t dbSNP:771666930
2658 2658 a, g dbSNP:774855087
2684 2684 a, t dbSNP:760382364
2691 2691 c, t dbSNP:3087425
2692 2692 a, g dbSNP:201442356
2693 2693 -, c dbSNP:748484883
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2700 2700 a, g dbSNP:762233119
2706 2706 g, t dbSNP:765666269
2708 2708 c, t dbSNP:779314628
2709 2709 a, g dbSNP:758819862
2712 2712 a, c, g dbSNP:748169173
2713 2713 c, t dbSNP:755249893
2733 2733 c, t dbSNP:567405400
2734 2734 a, g dbSNP:748334111
2736 2736 c, t dbSNP:757089385
2738 2738 g, t dbSNP:778662830
2744 2744 c, g dbSNP:745869554
2757 2757 -, gtc dbSNP:775125764
2760 2760 c, t dbSNP:201188293
2761 2761 a, g dbSNP:369971328
2762 2762 c, t dbSNP:3087432
2786 2786 c, t dbSNP:140176367
2787 2787 a, g dbSNP:776463866
2800 2800 c, t dbSNP:188554751
2801 2801 c, t dbSNP:199976474
2809 2809 -, ttaact dbSNP:777930678
2819 2819 c, t dbSNP:765756171
2826 2826 -, ctt dbSNP:749180567
2832 2832 a, c dbSNP:201958640
2838 2838 a, t dbSNP:769510537
2840 2840 a, g dbSNP:201806650
2841 2841 c, t dbSNP:763297475
2842 2842 a, g dbSNP:771294955
2856 2856 c, t dbSNP:774765029
2857 2857 a, g dbSNP:374262282
2861 2861 a, g dbSNP:767647726
2862 2862 c, t dbSNP:377553274
2868 2868 g, t dbSNP:764367192
2878 2878 c, t dbSNP:778405540
2880 2880 a, g dbSNP:760902935
2888 2888 a, g dbSNP:764253610
2892 2892 a, g dbSNP:750264937
2895 2895 a, t dbSNP:758167794
2907 2907 a, g dbSNP:751795043
2912 2912 a, t dbSNP:751513363
2917 2917 a, g dbSNP:754965109
2926 2926 a, g, t dbSNP:11574323
2931 2931 c, t dbSNP:751304410
2938 2938 a, c dbSNP:754985773
2942 2942 a, t dbSNP:201406649
2952 2952 -, a dbSNP:760298876
2969 2969 a, c dbSNP:142216807
2975 2975 a, g dbSNP:755729832
2980 2980 c, t dbSNP:777323246
2984 2984 a, g dbSNP:748959906
2990 2990 a, g dbSNP:770548815
3008 3008 c, t dbSNP:779156692
3013 3013 a, c dbSNP:746183898
3016 3016 c, g dbSNP:772600753
3017 3017 a, g dbSNP:778590283
3030 3030 c, t dbSNP:760584509
3035 3035 c, t dbSNP:151267769
3052 3052 a, t dbSNP:745491066
3065 3065 c, t dbSNP:765932330
3072 3072 c, g dbSNP:780384737
3077 3077 a, g dbSNP:146727423
3084 3084 a, g dbSNP:769143572
3086 3086 c, g dbSNP:776589924
3109 3109 c, g, t dbSNP:748216889
3113 3113 a, c, t dbSNP:773614544
3115 3115 a, c dbSNP:767486739
3127 3127 a, t dbSNP:775356894
3128 3128 c, g, t dbSNP:147802438
3131 3131 c, g dbSNP:374522855
3135 3135 c, t dbSNP:756832663
3137 3137 a, g dbSNP:145367571
3138 3138 a, g dbSNP:532588948
3141 3141 a, t dbSNP:146443310
3142 3142 c, t dbSNP:780405291
3150 3150 c, t dbSNP:747319628
3151 3151 a, g dbSNP:569405870
3168 3168 c, t dbSNP:749330842
3169 3169 a, g dbSNP:370713742
3174 3174 a, g dbSNP:140768346
3176 3176 c, t dbSNP:150095039
3177 3177 a, g dbSNP:138379977
3181 3181 a, g dbSNP:776286762
3186 3186 c, t dbSNP:761819112
3187 3187 a, g dbSNP:769665299
3192 3192 c, t dbSNP:374413412
3212 3212 a, c dbSNP:367867308
3215 3215 a, g dbSNP:184758404
3218 3218 a, t dbSNP:751280152
3219 3219 -, caaa dbSNP:748860208
3224 3224 -, ag dbSNP:759972548
3226 3226 a, c dbSNP:759101476
3233 3233 a, g dbSNP:371720457
3249 3249 c, t dbSNP:190364546
3250 3250 a, g dbSNP:115298665
3254 3254 g, t dbSNP:778382412
3276 3276 a, g dbSNP:754365120
3278 3278 a, g dbSNP:757463409
3279 3279 a, g dbSNP:143793363
3282 3282 c, g dbSNP:138492730
3288 3288 c, t dbSNP:143954702
3289 3289 a, g dbSNP:367789256
3292 3292 a, t dbSNP:200370409
3294 3294 a, g dbSNP:769756672
3298 3298 a, g dbSNP:773176431
3302 3302 c, t dbSNP:377211917
3303 3303 a, g dbSNP:749207633
3304 3304 c, t dbSNP:377096989
3306 3306 a, g dbSNP:113001550
3314 3314 c, t dbSNP:773664315
3316 3316 c, t dbSNP:759240091
3322 3322 c, t dbSNP:780547284
3323 3323 a, g dbSNP:775952540
3325 3325 a, g dbSNP:369095273
3339 3339 c, t dbSNP:777537726
3353 3353 c, t dbSNP:111426441
3354 3354 a, c, g dbSNP:770793076
3359 3359 a, g dbSNP:745330652
3364 3364 c, t dbSNP:147294573
3385 3385 c, t dbSNP:775053146
3387 3387 a, t dbSNP:760392886
3396 3396 c, t dbSNP:369044109
3397 3397 c, t dbSNP:777069176
3400 3400 g, t dbSNP:61761622
3402 3402 c, t dbSNP:61761623
3409 3409 a, g dbSNP:750552131
3413 3413 g, t dbSNP:1801195
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3434 3434 -, tg dbSNP:770947623
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4465 4465 c, t dbSNP:143771120
4466 4466 g, t dbSNP:753208401
4471 4471 a, c, g dbSNP:61751045
4481 4481 c, t dbSNP:754076485
4496 4496 c, t dbSNP:576895598
4516 4516 c, t dbSNP:369870659
4517 4517 c, t dbSNP:780816071
4524 4524 a, t dbSNP:375879048
4525 4525 g, t dbSNP:373140422
4527 4527 a, g dbSNP:779762531
4529 4529 g, t dbSNP:751322468
4530 4530 a, g dbSNP:754726306
4542 4542 c, t dbSNP:781126957
4580 4580 g, t dbSNP:751590895
4588 4588 a, g dbSNP:571070144
4595 4595 c, t dbSNP:752257643
4615 4615 c, t dbSNP:576422857
4630 4630 a, g dbSNP:779991041
4642 4642 a, c dbSNP:377567315
4648 4648 a, g dbSNP:556811074
4684 4684 c, t dbSNP:11574411
4685 4685 a, g, t dbSNP:536279745
4802 4802 a, g dbSNP:189143230
4804 4804 a, g dbSNP:754980223
4834 4834 a, g dbSNP:778671247
4861 4861 a, g dbSNP:147191291
4898 4898 a, t dbSNP:538307011
4901 4901 a, g dbSNP:558392613
4905 4905 c, g dbSNP:11574412
4957 4957 a, c, t dbSNP:369778842
4958 4958 a, g dbSNP:373416825
5001 5001 c, t dbSNP:11574413
5033 5033 c, g dbSNP:11574414
5037 5037 -, a dbSNP:777731812
5060 5060 a, g dbSNP:11574415
5064 5064 c, t dbSNP:11574416
5078 5078 a, g dbSNP:777411815
5094 5094 a, g dbSNP:11574417
5118 5118 g, t dbSNP:770372560

Target ORF information:

RefSeq Version XM_011544639
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens Werner syndrome, RecQ helicase-like (WRN), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_011544639

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT
GATGAAGATT TAGAAATGGA GATGCTTAAG TCTTTAGAAA ACCTCAATAG TGGCACGGTA
GAACCAACTC ATTCTAAATG CTTAAAAATG GAAAGAAATC TGGGTCTTCC TACTAAAGAA
GAAGAAGAAG ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT
TTGTGGCCAG CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC
AGTTTTAAAC CAGTTCAGTG GAAAGTGATT CATTCAGTAT TAGAAGAAAG AAGAGATAAT
GTTGCTGTCA TGGCAACTGG ATATGGAAAG AGTTTGTGCT TCCAGTATCC ACCTGTTTAT
GTAGGCAAGA TTGGCCTTGT TATCTCTCCC CTTATTTCTC TGATGGAAGA CCAAGTGCTA
CAGCTTAAAA TGTCCAACAT CCCAGCTTGC TTCCTTGGAT CAGCACAGTC AGAAAATGTT
CTAACAGATA TTAAATTAGG TAAATACCGG ATTGTATACG TAACTCCAGA ATACTGTTCA
GGTAACATGG GCCTGCTCCA GCAACTTGAG GCTGATATTG GTATCACGCT CATTGCTGTG
GATGAGGCTC ACTGTATTTC TGAGTGGGGG CATGATTTTA GGGATTCATT CAGGAAGTTG
GGCTCCCTAA AGACAGCACT GCCAATGGTT CCAATCGTTG CACTTACTGC TACTGCAAGT
TCTTCAATCC GGGAAGACAT TGTACGTTGC TTAAATCTGA GAAATCCTCA GATCACCTGT
ACTGGTTTTG ATCGACCAAA CCTGTATTTA GAAGTTAGGC GAAAAACAGG GAATATCCTT
CAGGATCTGC AGCCATTTCT TGTCAAAACA AGTTCCCACT GGGAATTTGA AGGTCCAACA
ATCATCTACT GTCCTTCTAG AAAAATGACA CAACAAGTTA CAGGTGAACT TAGGAAACTG
AATCTATCCT GTGGAACATA CCATGCGGGC ATGAGTTTTA GCACAAGGAA AGACATTCAT
CATAGGTTTG TAAGAGATGA AATTCAGTGT GTCATAGCTA CCATAGCTTT TGGAATGGGC
ATTAATAAAG CTGACATTCG CCAAGTCATT CATTACGGTG CTCCTAAGGA CATGGAATCA
TATTATCAGG AGATTGGTAG AGCTGGTCGT GATGGACTTC AAAGTTCTTG TCACGTCCTC
TGGGCTCCTG CAGACATTAA CTTAAATAGG CACCTTCTTA CTGAGATACG TAATGAGAAG
TTTCGATTAT ACAAATTAAA GATGATGGCA AAGATGGAAA AATATCTTCA TTCTAGCAGA
TGTAGGAGAC AAATCATCTT GTCTCATTTT GAGGACAAAC AAGTACAAAA AGCCTCCTTG
GGAATTATGG GAACTGAAAA ATGCTGTGAT AATTGCAGGT CCAGATTGGA TCATTGCTAT
TCCATGGATG ACTCAGAGGA TACATCCTGG GACTTTGGTC CACAAGCATT TAAGCTTTTG
TCTGCTGTGG ACATCTTAGG CGAAAAATTT GGAATTGGGC TTCCAATTTT ATTTCTCCGA
GGATCTAATT CTCAGCGTCT TGCCGATCAA TATCGCAGGC ACAGTTTATT TGGCACTGGC
AAGGATCAAA CAGAGAGTTG GTGGAAGGCT TTTTCCCGTC AGCTGATCAC TGAGGGATTC
TTGGTAGAAG TTTCTCGGTA TAACAAATTT ATGAAGATTT GCGCCCTTAC GAAAAAGGGT
AGAAATTGGC TTCATAAAGC TAATACAGAA TCTCAGAGCC TCATCCTTCA AGCTAATGAA
GAATTGTGTC CAAAGAAGTT GCTTCTGCCT AGTTCGAAAA CTGTATCTTC GGGCACCAAA
GAGCATTGTT ATAATCAAGT ACCAGTTGAA TTAAGTACAG AGAAGAAGTC TAACTTGGAG
AAGTTATATT CTTATAAACC ATGTGATAAG ATTTCTTCTG GGAGTAACAT TTCTAAAAAA
AGTATCATGG TACAGTCACC AGAAAAAGCT TACAGTTCCT CACAGCCTGT TATTTCGGCA
CAAGAGCAGG AGACTCAGAT TGTGTTATAT GGCAAATTGG TAGAAGCTAG GCAGAAACAT
GCCAATAAAA TGGATGTTCC CCCAGCTATT CTGGCAACAA ACAAGATACT GGTGGATATG
GCCAAAATGA GACCAACTAC GGTTGAAAAC GTAAAAAGGA TTGATGGTGT TTCTGAAGGC
AAAGCTGCCA TGTTGGCCCC TCTGTTGGAA GTCATCAAAC ATTTCTGCCA AACAAATAGT
GTTCAGACAG ACCTCTTTTC AAGTACAAAA CCTCAAGAAG AACAGAAGAC GAGTCTGGTA
GCAAAAAATA AAATATGCAC ACTTTCACAG TCTATGGCCA TCACATACTC TTTATTCCAA
GAAAAGAAGA TGCCTTTGAA GAGCATAGCT GAGAGCAGGA TTCTGCCTCT CATGACAATT
GGCATGCACT TATCCCAAGC GGTGAAAGCT GGCTGCCCCC TTGATTTGGA GCGAGCAGGC
CTGACTCCAG AGGTTCAGAA GATTATTGCT GATGTTATCC GAAACCCTCC CGTCAACTCA
GATATGAGTA AAATTAGCCT AATCAGAATG TTAGTTCCTG AAAACATTGA CACGTACCTT
ATCCACATGG CAATTGAGAT CCTTAAACAT GGTCCTGACA GCGGACTTCA ACCTTCATGT
GATGTCAACA AAAGGAGATG TTTTCCCGGT TCTGAAGAGA TCTGTTCAAG TTCTAAGAGA
AGCAAGGAAG AAGTAGGCAT CAATACTGAG ACTTCATCTG CAGAGAGAAA GAGACGATTA
CCTGTGTGGT TTGCCAAAGG AAGTGATACC AGCAAGAAAT TAATGGACAA AACGAAAAGG
GGAGGTCTTT TTAGTTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu61340D
Sequence Information ORF Nucleotide Sequence (Length: 2700bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product Werner syndrome ATP-dependent helicase isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167187.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT TTGTGGCCAG 
CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC AGTTTTAAAC
CGATATGGAA AGAGTTTGTG CTTCCAGTAT CCACCTGTTT ATGTAGGCAA GATTGGCCTT
GTTATCTCTC CCCTTATTTC TCTGATGGAA GACCAAGTGC TACAGCTTAA AATGTCCAAC
ATCCCAGCTT GCTTCCTTGG ATCAGCACAG TCAGAAAATG TTCTAACAGA TATTAAATTA
GGTAAATACC GGATTGTATA CGTAACTCCA GAATACTGTT CAGGTAACAT GGGCCTGCTC
CAGCAACTTG AGGCTGATAT TGGTATCACG CTCATTGCTG TGGATGAGGC TCACTGTATT
TCTGAGTGGG GGCATGATTT TAGGGATTCA TTCAGGAAGT TGGGCTCCCT AAAGACAGCA
CTGCCAATGG TTCCAATCGT TGCACTTACT GCTACTGCAA GTTCTTCAAT CCGGGAAGAC
ATTGTACGTT GCTTAAATCT GAGAAATCCT CAGATCACCT GTACTGGTTT TGATCGACCA
AACCTGTATT TAGAAGTTAG GCGAAAAACA GGGAATATCC TTCAGGATCT GCAGCCATTT
CTTGTCAAAA CAAGTTCCCA CTGGGAATTT GAAGGTCCAA CAATCATCTA CTGTCCTTCT
AGAAAAATGA CACAACAAGT TACAGGTGAA CTTAGGAAAC TGAATCTATC CTGTGGAACA
TACCATGCGG GCATGAGTTT TAGCACAAGG AAAGACATTC ATCATAGGTT TGTAAGAGAT
GAAATTCAGT GTGTCATAGC TACCATAGCT TTTGGAATGG GCATTAATAA AGCTGACATT
CGCCAAGTCA TTCATTACGG TGCTCCTAAG GACATGGAAT CATATTATCA GGAGATTGGT
AGAGCTGGTC GTGATGGACT TCAAAGTTCT TGTCACGTCC TCTGGGCTCC TGCAGACATT
AACTTAAATA GGCACCTTCT TACTGAGATA CGTAATGAGA AGTTTCGATT ATACAAATTA
AAGATGATGG CAAAGATGGA AAAATATCTT CATTCTAGCA GATGTAGGAG ACAAATCATC
TTGTCTCATT TTGAGGACAA ACAAGTACAA AAAGCCTCCT TGGGAATTAT GGGAACTGAA
AAATGCTGTG ATAATTGCAG GTCCAGATTG GATCATTGCT ATTCCATGGA TGACTCAGAG
GATACATCCT GGGACTTTGG TCCACAAGCA TTTAAGCTTT TGTCTGCTGT GGACATCTTA
GGCGAAAAAT TTGGAATTGG GCTTCCAATT TTATTTCTCC GAGGATCTAA TTCTCAGCGT
CTTGCCGATC AATATCGCAG GCACAGTTTA TTTGGCACTG GCAAGGATCA AACAGAGAGT
TGGTGGAAGG CTTTTTCCCG TCAGCTGATC ACTGAGGGAT TCTTGGTAGA AGTTTCTCGG
TATAACAAAT TTATGAAGAT TTGCGCCCTT ACGAAAAAGG GTAGAAATTG GCTTCATAAA
GCTAATACAG AATCTCAGAG CCTCATCCTT CAAGCTAATG AAGAATTGTG TCCAAAGAAG
TTGCTTCTGC CTAGTTCGAA AACTGTATCT TCGGGCACCA AAGAGCATTG TTATAATCAA
GTACCAGTTG AATTAAGTAC AGAGAAGAAG TCTAACTTGG AGAAGTTATA TTCTTATAAA
CCATGTGATA AGATTTCTTC TGGGAGTAAC ATTTCTAAAA AAAGTATCAT GGTACAGTCA
CCAGAAAAAG CTTACAGTTC CTCACAGCCT GTTATTTCGG CACAAGAGCA GGAGACTCAG
ATTGTGTTAT ATGGCAAATT GGTAGAAGCT AGGCAGAAAC ATGCCAATAA AATGGATGTT
CCCCCAGCTA TTCTGGCAAC AAACAAGATA CTGGTGGATA TGGCCAAAAT GAGACCAACT
ACGGTTGAAA ACGTAAAAAG GATTGATGGT GTTTCTGAAG GCAAAGCTGC CATGTTGGCC
CCTCTGTTGG AAGTCATCAA ACATTTCTGC CAAACAAATA GTGTTCAGAC AGACCTCTTT
TCAAGTACAA AACCTCAAGA AGAACAGAAG ACGAGTCTGG TAGCAAAAAA TAAAATATGC
ACACTTTCAC AGTCTATGGC CATCACATAC TCTTTATTCC AAGAAAAGAA GATGCCTTTG
AAGAGCATAG CTGAGAGCAG GATTCTGCCT CTCATGACAA TTGGCATGCA CTTATCCCAA
GCGGTGAAAG CTGGCTGCCC CCTTGATTTG GAGCGAGCAG GCCTGACTCC AGAGGTTCAG
AAGATTATTG CTGATGTTAT CCGAAACCCT CCCGTCAACT CAGATATGAG TAAAATTAGC
CTAATCAGAA TGTTAGTTCC TGAAAACATT GACACGTACC TTATCCACAT GGCAATTGAG
ATCCTTAAAC ATGGTCCTGA CAGCGGACTT CAACCTTCAT GTGATGTCAA CAAAAGGAGA
TGTTTTCCCG GTTCTGAAGA GATCTGTTCA AGTTCTAAGA GAAGCAAGGA AGAAGTAGGC
ATCAATACTG AGACTTCATC TGCAGAGAGA AAGAGACGAT TACCTGTGTG GTTTGCCAAA
GGAAGTGATA CCAGCAAGAA ATTAATGGAC AAAACGAAAA GGGGAGGTCT TTTTAGTTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_011542942.1
CDS101..2800
Misc Feature(1)224..1531(+)
Misc Feature(2)227..616(+)
Misc Feature(3)227..235(+)
Misc Feature(4)503..514(+)
Misc Feature(5)776..1102(+)
Misc Feature(6)815..970(+)
Misc Feature(7)986..1072(+)
Misc Feature(8)1373..1654(+)
Misc Feature(9)1967..2188(+)
Misc Feature(10)2270..2557(+)
Translation
Position Chain Variation Link
1 1 c, t dbSNP:745685947
4 4 c, t dbSNP:545516221
8 8 a, t dbSNP:775240079
12 12 c, t dbSNP:760660037
17 17 a, g dbSNP:764011979
20 20 g, t dbSNP:776008000
26 26 c, t dbSNP:761328537
27 27 c, g dbSNP:764818941
35 35 c, t dbSNP:750052448
37 37 a, t dbSNP:758101797
44 44 c, t dbSNP:766910166
54 54 -, aaaa dbSNP:751112452
55 55 a, t dbSNP:751969803
73 73 c, g dbSNP:755548890
74 74 g, t dbSNP:201172985
76 76 c, t dbSNP:752745117
78 78 c, t dbSNP:756183348
82 82 a, c dbSNP:777679266
83 83 c, t dbSNP:749569654
86 86 -, aagaag dbSNP:781777438
86 86 -, aag dbSNP:555283914
96 96 a, c dbSNP:771126045
98 98 a, g dbSNP:113811718
99 99 -, gat dbSNP:746348167
99 99 a, g, t dbSNP:149565907
100 100 c, g, t dbSNP:368413625
101 101 a, g dbSNP:761259830
102 102 a, t dbSNP:531326550
104 104 a, t dbSNP:763266496
106 106 c, g dbSNP:772584887
112 112 c, g dbSNP:376345065
132 132 a, c dbSNP:747825738
135 135 g, t dbSNP:751988233
137 137 -, a dbSNP:770352933
139 139 a, g dbSNP:759933355
147 147 -, c dbSNP:780555196
151 151 a, c, t dbSNP:752994352
156 156 a, g dbSNP:369741345
163 163 c, t dbSNP:764445113
167 167 c, t dbSNP:11574240
168 168 c, t dbSNP:757279675
173 173 a, t dbSNP:765475534
177 177 a, g dbSNP:540506828
187 187 c, t dbSNP:750684158
197 197 a, c dbSNP:151001436
221 221 c, t dbSNP:781107893
225 225 a, g dbSNP:757269649
226 226 c, t dbSNP:13438802
231 231 a, t dbSNP:121908448
241 241 c, t dbSNP:749974657
245 245 c, t dbSNP:757808169
254 254 c, t dbSNP:554671327
257 257 c, g dbSNP:746690931
261 261 a, t dbSNP:137977751
262 262 c, t dbSNP:372635306
263 263 a, g dbSNP:587778747
269 269 a, t dbSNP:770306531
277 277 a, c dbSNP:773549958
284 284 a, t dbSNP:763482212
287 287 c, t dbSNP:374514457
289 289 c, t dbSNP:13438803
296 296 a, g dbSNP:368931681
307 307 c, g dbSNP:201586173
314 314 c, g dbSNP:753701726
315 315 a, g dbSNP:761654576
319 319 a, g dbSNP:765298638
322 322 a, g dbSNP:750369623
325 325 a, g dbSNP:758335587
327 327 a, t dbSNP:779488238
332 332 a, g dbSNP:762866297
334 334 a, g dbSNP:766281234
336 336 c, g dbSNP:11574250
339 339 a, g dbSNP:754443271
341 341 a, g dbSNP:577000913
351 351 g, t dbSNP:752392526
354 354 g, t dbSNP:755746575
380 380 a, g dbSNP:374688634
383 383 c, g dbSNP:77969734
387 387 c, t dbSNP:757722268
390 390 a, g dbSNP:779430282
395 395 a, g dbSNP:745979339
402 402 a, c, g dbSNP:759533715
404 404 a, g dbSNP:774998815
408 408 a, g dbSNP:569266355
410 410 a, c, t dbSNP:148286708
418 418 a, g dbSNP:200291937
421 421 c, t dbSNP:765756226
422 422 a, g dbSNP:572026265
433 433 a, g dbSNP:758979216
443 443 c, g dbSNP:780657433
454 454 c, t dbSNP:11574263
458 458 c, g dbSNP:373177461
459 459 c, t dbSNP:781109286
465 465 a, t dbSNP:376938452
476 476 a, g dbSNP:769901163
483 483 g, t dbSNP:755426500
485 485 a, g dbSNP:781397548
488 488 a, t dbSNP:754509612
489 489 c, t dbSNP:752650803
490 490 a, g, t dbSNP:201982706
494 494 a, g dbSNP:754104065
500 500 a, g, t dbSNP:748097536
505 505 c, t dbSNP:575593855
508 508 a, g dbSNP:745697860
524 524 c, g dbSNP:758232075
528 528 a, g dbSNP:779805817
530 530 a, g dbSNP:747026081
531 531 a, g dbSNP:543878821
532 532 a, g dbSNP:776209945
534 534 a, g dbSNP:747555501
536 536 a, g dbSNP:769600792
553 553 c, t dbSNP:148385320
558 558 a, g dbSNP:370522829
560 560 g, t dbSNP:185468906
568 568 c, t dbSNP:191757062
579 579 c, g, t dbSNP:760090174
584 584 c, t dbSNP:752841355
587 587 a, g dbSNP:756149876
592 592 a, t dbSNP:781016211
593 593 c, g dbSNP:752740258
596 596 a, g dbSNP:756115593
598 598 c, t dbSNP:777423206
605 605 c, t dbSNP:748745844
609 609 c, g, t dbSNP:201384942
613 613 c, t dbSNP:745506503
615 615 c, t dbSNP:141563618
617 617 g, t dbSNP:775913837
619 619 -, aa dbSNP:762855622
620 620 a, c, g dbSNP:761240520
624 624 c, t dbSNP:11574289
629 629 a, g dbSNP:180814740
632 632 c, t dbSNP:34560788
633 633 a, c, g dbSNP:750658657
639 639 a, g dbSNP:767281534
641 641 a, g dbSNP:752472638
643 643 c, t dbSNP:756129972
647 647 c, t dbSNP:201990558
648 648 a, g dbSNP:753428420
666 666 a, g dbSNP:186693124
669 669 a, c dbSNP:778467522
672 672 a, g dbSNP:372795551
676 676 c, t dbSNP:771754762
680 680 -, t dbSNP:281865158
686 686 a, g dbSNP:558054655
693 693 a, t dbSNP:747317429
695 695 c, t dbSNP:143916053
696 696 a, g dbSNP:777084325
702 702 a, g dbSNP:762358256
708 708 a, g dbSNP:769819743
716 716 a, g dbSNP:773337566
722 722 c, t dbSNP:763089663
723 723 a, g dbSNP:766561388
726 726 a, c dbSNP:374156628
732 732 a, g dbSNP:368402409
734 734 a, g dbSNP:763947488
735 735 a, c dbSNP:753878041
738 738 g, t dbSNP:757207256
739 739 a, c dbSNP:764724926
740 740 c, g dbSNP:749885093
742 742 g, t dbSNP:2230011
745 745 -, tat dbSNP:763767781
750 750 c, t dbSNP:779633784
751 751 g, t dbSNP:747407604
757 757 a, g dbSNP:372016270
764 764 a, g dbSNP:769448856
774 774 a, g dbSNP:748667880
782 782 c, t dbSNP:200009031
790 790 a, t dbSNP:751269220
795 795 -, tccaacaa dbSNP:755433977
795 795 a, g dbSNP:754619565
797 797 c, g dbSNP:781541304
798 798 c, g dbSNP:748486712
800 800 a, g dbSNP:756597086
801 801 c, g, t dbSNP:201282577
803 803 a, g dbSNP:771180836
808 808 c, t dbSNP:538573677
813 813 c, g dbSNP:746161973
816 816 c, t dbSNP:140730934
829 829 a, g, t dbSNP:555281600
832 832 a, g dbSNP:375863936
839 839 a, g dbSNP:574787451
843 843 c, t dbSNP:17847568
854 854 a, c dbSNP:765938062
856 856 a, g dbSNP:751002549
862 862 g, t dbSNP:1800392
867 867 c, t dbSNP:767108016
871 871 a, c, t dbSNP:753030891
872 872 g, t dbSNP:200169079
873 873 a, g dbSNP:754423621
874 874 c, t dbSNP:757837913
888 888 c, t dbSNP:779140898
901 901 a, t dbSNP:750944794
902 902 a, c dbSNP:745889273
912 912 a, g dbSNP:145698720
916 916 c, t dbSNP:780284174
917 917 a, g dbSNP:200935416
923 923 c, t dbSNP:369776725
924 924 a, g dbSNP:377012608
940 940 a, t dbSNP:182891206
948 948 a, g dbSNP:762881466
951 951 c, g dbSNP:774308552
961 961 c, g, t dbSNP:1800393
964 964 c, t dbSNP:771666930
968 968 a, g dbSNP:774855087
994 994 a, t dbSNP:760382364
1001 1001 c, t dbSNP:3087425
1002 1002 a, g dbSNP:201442356
1003 1003 -, c dbSNP:748484883
1009 1009 c, t dbSNP:777161223
1010 1010 a, g dbSNP:762233119
1016 1016 g, t dbSNP:765666269
1018 1018 c, t dbSNP:779314628
1019 1019 a, g dbSNP:758819862
1022 1022 a, c, g dbSNP:748169173
1023 1023 c, t dbSNP:755249893
1043 1043 c, t dbSNP:567405400
1044 1044 a, g dbSNP:748334111
1046 1046 c, t dbSNP:757089385
1048 1048 g, t dbSNP:778662830
1054 1054 c, g dbSNP:745869554
1067 1067 -, gtc dbSNP:775125764
1070 1070 c, t dbSNP:201188293
1071 1071 a, g dbSNP:369971328
1072 1072 c, t dbSNP:3087432
1096 1096 c, t dbSNP:140176367
1097 1097 a, g dbSNP:776463866
1110 1110 c, t dbSNP:188554751
1111 1111 c, t dbSNP:199976474
1119 1119 -, ttaact dbSNP:777930678
1129 1129 c, t dbSNP:765756171
1136 1136 -, ctt dbSNP:749180567
1142 1142 a, c dbSNP:201958640
1148 1148 a, t dbSNP:769510537
1150 1150 a, g dbSNP:201806650
1151 1151 c, t dbSNP:763297475
1152 1152 a, g dbSNP:771294955
1166 1166 c, t dbSNP:774765029
1167 1167 a, g dbSNP:374262282
1171 1171 a, g dbSNP:767647726
1172 1172 c, t dbSNP:377553274
1178 1178 g, t dbSNP:764367192
1188 1188 c, t dbSNP:778405540
1190 1190 a, g dbSNP:760902935
1198 1198 a, g dbSNP:764253610
1202 1202 a, g dbSNP:750264937
1205 1205 a, t dbSNP:758167794
1217 1217 a, g dbSNP:751795043
1222 1222 a, t dbSNP:751513363
1227 1227 a, g dbSNP:754965109
1236 1236 a, g, t dbSNP:11574323
1241 1241 c, t dbSNP:751304410
1248 1248 a, c dbSNP:754985773
1252 1252 a, t dbSNP:201406649
1262 1262 -, a dbSNP:760298876
1279 1279 a, c dbSNP:142216807
1285 1285 a, g dbSNP:755729832
1290 1290 c, t dbSNP:777323246
1294 1294 a, g dbSNP:748959906
1300 1300 a, g dbSNP:770548815
1318 1318 c, t dbSNP:779156692
1323 1323 a, c dbSNP:746183898
1326 1326 c, g dbSNP:772600753
1327 1327 a, g dbSNP:778590283
1340 1340 c, t dbSNP:760584509
1345 1345 c, t dbSNP:151267769
1362 1362 a, t dbSNP:745491066
1375 1375 c, t dbSNP:765932330
1382 1382 c, g dbSNP:780384737
1387 1387 a, g dbSNP:146727423
1394 1394 a, g dbSNP:769143572
1396 1396 c, g dbSNP:776589924
1419 1419 c, g, t dbSNP:748216889
1423 1423 a, c, t dbSNP:773614544
1425 1425 a, c dbSNP:767486739
1437 1437 a, t dbSNP:775356894
1438 1438 c, g, t dbSNP:147802438
1441 1441 c, g dbSNP:374522855
1445 1445 c, t dbSNP:756832663
1447 1447 a, g dbSNP:145367571
1448 1448 a, g dbSNP:532588948
1451 1451 a, t dbSNP:146443310
1452 1452 c, t dbSNP:780405291
1460 1460 c, t dbSNP:747319628
1461 1461 a, g dbSNP:569405870
1478 1478 c, t dbSNP:749330842
1479 1479 a, g dbSNP:370713742
1484 1484 a, g dbSNP:140768346
1486 1486 c, t dbSNP:150095039
1487 1487 a, g dbSNP:138379977
1491 1491 a, g dbSNP:776286762
1496 1496 c, t dbSNP:761819112
1497 1497 a, g dbSNP:769665299
1502 1502 c, t dbSNP:374413412
1522 1522 a, c dbSNP:367867308
1525 1525 a, g dbSNP:184758404
1528 1528 a, t dbSNP:751280152
1529 1529 -, caaa dbSNP:748860208
1534 1534 -, ag dbSNP:759972548
1536 1536 a, c dbSNP:759101476
1543 1543 a, g dbSNP:371720457
1559 1559 c, t dbSNP:190364546
1560 1560 a, g dbSNP:115298665
1564 1564 g, t dbSNP:778382412
1586 1586 a, g dbSNP:754365120
1588 1588 a, g dbSNP:757463409
1589 1589 a, g dbSNP:143793363
1592 1592 c, g dbSNP:138492730
1598 1598 c, t dbSNP:143954702
1599 1599 a, g dbSNP:367789256
1602 1602 a, t dbSNP:200370409
1604 1604 a, g dbSNP:769756672
1608 1608 a, g dbSNP:773176431
1612 1612 c, t dbSNP:377211917
1613 1613 a, g dbSNP:749207633
1614 1614 c, t dbSNP:377096989
1616 1616 a, g dbSNP:113001550
1624 1624 c, t dbSNP:773664315
1626 1626 c, t dbSNP:759240091
1632 1632 c, t dbSNP:780547284
1633 1633 a, g dbSNP:775952540
1635 1635 a, g dbSNP:369095273
1649 1649 c, t dbSNP:777537726
1663 1663 c, t dbSNP:111426441
1664 1664 a, c, g dbSNP:770793076
1669 1669 a, g dbSNP:745330652
1674 1674 c, t dbSNP:147294573
1695 1695 c, t dbSNP:775053146
1697 1697 a, t dbSNP:760392886
1706 1706 c, t dbSNP:369044109
1707 1707 c, t dbSNP:777069176
1710 1710 g, t dbSNP:61761622
1712 1712 c, t dbSNP:61761623
1719 1719 a, g dbSNP:750552131
1723 1723 g, t dbSNP:1801195
1725 1725 c, t dbSNP:766463285
1731 1731 c, t dbSNP:751843882
1733 1733 a, g dbSNP:543930395
1737 1737 a, c, t dbSNP:3087414
1738 1738 a, g dbSNP:11574345
1744 1744 -, tg dbSNP:770947623
1745 1745 c, g dbSNP:778754032
1745 1745 -, g dbSNP:745905108
1752 1752 c, t dbSNP:587778748
1760 1760 a, g dbSNP:374154973
1784 1784 c, t dbSNP:779724704
1785 1785 c, t dbSNP:746470648
1789 1789 a, t dbSNP:768458255
1803 1803 a, c dbSNP:781035646
1804 1804 a, g dbSNP:747782749
1810 1810 g, t dbSNP:770117143
1824 1824 a, c dbSNP:201274303
1829 1829 c, g, t dbSNP:368115321
1836 1836 a, g dbSNP:113532342
1841 1841 c, t dbSNP:749621372
1851 1851 a, c dbSNP:771167567
1852 1852 g, t dbSNP:774886450
1860 1860 c, t dbSNP:746361330
1866 1866 c, g dbSNP:772205458
1876 1876 c, t dbSNP:377535272
1877 1877 -, a dbSNP:778872619
1884 1884 c, g dbSNP:775482053
1887 1887 a, t dbSNP:761932192
1889 1889 a, t dbSNP:532384887
1890 1890 c, t dbSNP:774227681
1892 1892 a, g dbSNP:759564734
1896 1896 a, g dbSNP:146265072
1898 1898 g, t dbSNP:11574358
1910 1910 a, g dbSNP:545826298
1912 1912 g, t dbSNP:767519655
1918 1918 c, t dbSNP:752542644
1920 1920 a, c dbSNP:760280044
1923 1923 c, t dbSNP:139323683
1933 1933 g, t dbSNP:753592904
1934 1934 a, c dbSNP:756835995
1935 1935 c, t dbSNP:760910926
1938 1938 c, t dbSNP:779264260
1939 1939 a, g dbSNP:750737389
1954 1954 a, g dbSNP:144116311
1956 1956 a, c dbSNP:200240557
1965 1965 c, t dbSNP:769961391
1969 1969 a, g, t dbSNP:576208057
1972 1972 c, t dbSNP:146480453
1994 1994 c, t dbSNP:121908447
1999 1999 a, g dbSNP:771967255
2001 2001 a, g dbSNP:149071983
2007 2007 a, g dbSNP:587778750
2022 2022 c, t dbSNP:182077287
2024 2024 a, c dbSNP:768430448
2029 2029 c, t dbSNP:142109468
2030 2030 a, g dbSNP:761354888
2038 2038 a, g dbSNP:764706761
2039 2039 a, g dbSNP:772910372
2044 2044 -, a dbSNP:770556928
2060 2060 a, g dbSNP:762592772
2074 2074 a, g dbSNP:200018117
2081 2081 a, g dbSNP:754007268
2082 2082 c, t dbSNP:376068344
2083 2083 a, g, t dbSNP:762685242
2085 2085 c, t dbSNP:550252124
2088 2088 -, a dbSNP:770667024
2089 2089 a, g dbSNP:61761624
2091 2091 -, a dbSNP:281865160
2092 2092 c, t dbSNP:151143960
2093 2093 a, c, g dbSNP:147116477
2095 2095 a, g dbSNP:764282607
2105 2105 a, g dbSNP:753920588
2111 2111 c, g dbSNP:757530533
2114 2114 c, t dbSNP:368955181
2117 2117 c, g dbSNP:746082406
2124 2124 a, g dbSNP:529421538
2128 2128 a, t dbSNP:780963410
2131 2131 c, t dbSNP:748084810
2132 2132 a, g dbSNP:769665112
2141 2141 c, g dbSNP:371980000
2143 2143 c, t dbSNP:777291010
2147 2147 c, t dbSNP:549673147
2150 2150 a, g dbSNP:376485135
2160 2160 a, g dbSNP:755045369
2166 2166 g, t dbSNP:17847574
2169 2169 c, g dbSNP:773929985
2176 2176 a, g dbSNP:759219832
2177 2177 a, g, t dbSNP:566277794
2187 2187 a, c, t dbSNP:369158322
2190 2190 a, c dbSNP:776027380
2191 2191 -, agac dbSNP:606231162
2200 2200 g, t dbSNP:761162177
2204 2204 a, c dbSNP:769121831
2205 2205 a, g dbSNP:777064429
2208 2208 c, t dbSNP:140064662
2225 2225 c, t dbSNP:762379051
2232 2232 c, t dbSNP:370299361
2233 2233 a, g dbSNP:750463286
2239 2239 a, g dbSNP:147117969
2245 2245 a, g dbSNP:766552266
2256 2256 c, t dbSNP:751754209
2269 2269 a, g dbSNP:755957592
2272 2272 a, g dbSNP:777616472
2279 2279 a, g dbSNP:201107091
2281 2281 -, a dbSNP:757487317
2282 2282 a, g, t dbSNP:201661079
2286 2286 c, g dbSNP:78488552
2300 2300 c, t dbSNP:757950531
2302 2302 a, g dbSNP:779902531
2304 2304 -, a dbSNP:781412016
2306 2306 a, g dbSNP:746648510
2314 2314 a, g dbSNP:769211927
2315 2315 c, g dbSNP:776989868
2331 2331 c, g dbSNP:199849137
2337 2337 a, g dbSNP:767033541
2339 2339 a, g dbSNP:753619197
2351 2351 c, t dbSNP:368876038
2355 2355 g, t dbSNP:371799306
2360 2360 a, g dbSNP:757172649
2363 2363 a, g dbSNP:765259410
2371 2371 c, t dbSNP:750364571
2376 2376 a, c, g dbSNP:142614369
2377 2377 c, t dbSNP:746666880
2382 2382 c, t dbSNP:146861737
2383 2383 a, g dbSNP:781435643
2386 2386 a, g dbSNP:551020765
2394 2394 g, t dbSNP:202129203
2398 2398 c, t dbSNP:773822420
2400 2400 c, t dbSNP:533336892
2401 2401 a, c, g dbSNP:138886038
2411 2411 c, g dbSNP:759805320
2414 2414 c, t dbSNP:121908446
2415 2415 a, g dbSNP:775535952
2416 2416 -, a dbSNP:587776621
2417 2417 a, g dbSNP:759484995
2418 2418 c, t dbSNP:761690581
2430 2430 c, t dbSNP:375176583
2447 2447 a, g dbSNP:750389299
2448 2448 c, t dbSNP:377596908
2461 2461 -, c dbSNP:756173427
2463 2463 a, c, g dbSNP:766042685
2471 2471 c, t dbSNP:754624193
2473 2473 c, g, t dbSNP:370253199
2474 2474 a, g dbSNP:756510312
2479 2479 c, t dbSNP:778109129
2487 2487 c, t dbSNP:755711042
2490 2490 a, g dbSNP:778162176
2491 2491 g, t dbSNP:11547230
2497 2497 c, t dbSNP:754171903
2502 2502 g, t dbSNP:200403732
2511 2511 c, t dbSNP:779419290
2512 2512 a, g dbSNP:544317387
2516 2516 a, g, t dbSNP:11574395
2519 2519 c, t dbSNP:747312018
2520 2520 c, t dbSNP:768974963
2525 2525 a, c dbSNP:773178758
2527 2527 c, t dbSNP:762868798
2529 2529 c, t dbSNP:770796609
2534 2534 a, c dbSNP:774438611
2535 2535 a, c dbSNP:759390217
2536 2536 a, g dbSNP:767115441
2540 2540 a, c dbSNP:752127887
2543 2543 a, g dbSNP:374028957
2544 2544 g, t dbSNP:760417225
2545 2545 c, t dbSNP:763768734
2552 2552 a, g dbSNP:587778752
2555 2555 a, g dbSNP:368551262
2564 2564 c, t dbSNP:757631368
2571 2571 a, g dbSNP:765518421
2582 2582 a, g dbSNP:751004956
2584 2584 c, t dbSNP:1801196
2585 2585 a, g dbSNP:780229859
2586 2586 a, g dbSNP:372005303
2590 2590 c, t dbSNP:747026440
2600 2600 c, t dbSNP:1346044
2601 2601 a, g dbSNP:781583408
2602 2602 c, t dbSNP:201955394
2604 2604 a, t dbSNP:770921190
2609 2609 -, a dbSNP:748089844
2612 2612 -, a dbSNP:772047427
2612 2612 a, c dbSNP:774007667
2622 2622 a, g dbSNP:745870422
2624 2624 c, t dbSNP:112224806
2627 2627 -, c dbSNP:766643585
2628 2628 c, t dbSNP:146055899
2629 2629 c, t dbSNP:545168763
2630 2630 a, g dbSNP:760127655
2640 2640 a, g dbSNP:763538154
2641 2641 a, g dbSNP:776270050
2646 2646 a, g dbSNP:761450405
2666 2666 a, g dbSNP:587778751
2671 2671 a, g dbSNP:750730139
2679 2679 c, g, t dbSNP:186424616
2681 2681 a, g dbSNP:545431480
2685 2685 a, g dbSNP:755118429
2692 2692 a, g dbSNP:369276959
2693 2693 a, g dbSNP:767758699
2694 2694 c, t dbSNP:752795658
2695 2695 g, t dbSNP:756225803
2704 2704 a, g dbSNP:777881622
2717 2717 c, t dbSNP:11574410
2718 2718 a, g dbSNP:758132889
2719 2719 a, g dbSNP:779894987
2724 2724 c, t dbSNP:764468799
2729 2729 c, t dbSNP:768558349
2730 2730 g, t dbSNP:780718250
2741 2741 c, g dbSNP:747685773
2745 2745 -, t dbSNP:746732427
2749 2749 c, t dbSNP:112024742
2752 2752 c, t dbSNP:772748725
2754 2754 a, g dbSNP:762597300
2757 2757 a, c dbSNP:771261660
2761 2761 a, c dbSNP:774839008
2766 2766 c, t dbSNP:760164017
2775 2775 c, t dbSNP:143771120
2776 2776 g, t dbSNP:753208401
2781 2781 a, c, g dbSNP:61751045
2791 2791 c, t dbSNP:754076485
2806 2806 c, t dbSNP:576895598
2826 2826 c, t dbSNP:369870659
2827 2827 c, t dbSNP:780816071
2834 2834 a, t dbSNP:375879048
2835 2835 g, t dbSNP:373140422
2837 2837 a, g dbSNP:779762531
2839 2839 g, t dbSNP:751322468
2840 2840 a, g dbSNP:754726306
2852 2852 c, t dbSNP:781126957
2890 2890 g, t dbSNP:751590895
2898 2898 a, g dbSNP:571070144
2905 2905 c, t dbSNP:752257643
2925 2925 c, t dbSNP:576422857
2940 2940 a, g dbSNP:779991041
2952 2952 a, c dbSNP:377567315
2958 2958 a, g dbSNP:556811074
2994 2994 c, t dbSNP:11574411
2995 2995 a, g, t dbSNP:536279745
3112 3112 a, g dbSNP:189143230
3114 3114 a, g dbSNP:754980223
3144 3144 a, g dbSNP:778671247
3171 3171 a, g dbSNP:147191291
3208 3208 a, t dbSNP:538307011
3211 3211 a, g dbSNP:558392613
3215 3215 c, g dbSNP:11574412
3267 3267 a, c, t dbSNP:369778842
3268 3268 a, g dbSNP:373416825
3311 3311 c, t dbSNP:11574413
3343 3343 c, g dbSNP:11574414
3347 3347 -, a dbSNP:777731812
3370 3370 a, g dbSNP:11574415
3374 3374 c, t dbSNP:11574416
3388 3388 a, g dbSNP:777411815
3404 3404 a, g dbSNP:11574417
3428 3428 g, t dbSNP:770372560

Target ORF information:

RefSeq Version XM_011544640
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens Werner syndrome, RecQ helicase-like (WRN), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_011544640

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGATGAAAA TGAAGCTAAT GAAGGGGAAG AAGATGATGA TAAGGACTTT TTGTGGCCAG 
CACCCAATGA AGAGCAAGTT ACTTGCCTCA AGATGTACTT TGGCCATTCC AGTTTTAAAC
CGATATGGAA AGAGTTTGTG CTTCCAGTAT CCACCTGTTT ATGTAGGCAA GATTGGCCTT
GTTATCTCTC CCCTTATTTC TCTGATGGAA GACCAAGTGC TACAGCTTAA AATGTCCAAC
ATCCCAGCTT GCTTCCTTGG ATCAGCACAG TCAGAAAATG TTCTAACAGA TATTAAATTA
GGTAAATACC GGATTGTATA CGTAACTCCA GAATACTGTT CAGGTAACAT GGGCCTGCTC
CAGCAACTTG AGGCTGATAT TGGTATCACG CTCATTGCTG TGGATGAGGC TCACTGTATT
TCTGAGTGGG GGCATGATTT TAGGGATTCA TTCAGGAAGT TGGGCTCCCT AAAGACAGCA
CTGCCAATGG TTCCAATCGT TGCACTTACT GCTACTGCAA GTTCTTCAAT CCGGGAAGAC
ATTGTACGTT GCTTAAATCT GAGAAATCCT CAGATCACCT GTACTGGTTT TGATCGACCA
AACCTGTATT TAGAAGTTAG GCGAAAAACA GGGAATATCC TTCAGGATCT GCAGCCATTT
CTTGTCAAAA CAAGTTCCCA CTGGGAATTT GAAGGTCCAA CAATCATCTA CTGTCCTTCT
AGAAAAATGA CACAACAAGT TACAGGTGAA CTTAGGAAAC TGAATCTATC CTGTGGAACA
TACCATGCGG GCATGAGTTT TAGCACAAGG AAAGACATTC ATCATAGGTT TGTAAGAGAT
GAAATTCAGT GTGTCATAGC TACCATAGCT TTTGGAATGG GCATTAATAA AGCTGACATT
CGCCAAGTCA TTCATTACGG TGCTCCTAAG GACATGGAAT CATATTATCA GGAGATTGGT
AGAGCTGGTC GTGATGGACT TCAAAGTTCT TGTCACGTCC TCTGGGCTCC TGCAGACATT
AACTTAAATA GGCACCTTCT TACTGAGATA CGTAATGAGA AGTTTCGATT ATACAAATTA
AAGATGATGG CAAAGATGGA AAAATATCTT CATTCTAGCA GATGTAGGAG ACAAATCATC
TTGTCTCATT TTGAGGACAA ACAAGTACAA AAAGCCTCCT TGGGAATTAT GGGAACTGAA
AAATGCTGTG ATAATTGCAG GTCCAGATTG GATCATTGCT ATTCCATGGA TGACTCAGAG
GATACATCCT GGGACTTTGG TCCACAAGCA TTTAAGCTTT TGTCTGCTGT GGACATCTTA
GGCGAAAAAT TTGGAATTGG GCTTCCAATT TTATTTCTCC GAGGATCTAA TTCTCAGCGT
CTTGCCGATC AATATCGCAG GCACAGTTTA TTTGGCACTG GCAAGGATCA AACAGAGAGT
TGGTGGAAGG CTTTTTCCCG TCAGCTGATC ACTGAGGGAT TCTTGGTAGA AGTTTCTCGG
TATAACAAAT TTATGAAGAT TTGCGCCCTT ACGAAAAAGG GTAGAAATTG GCTTCATAAA
GCTAATACAG AATCTCAGAG CCTCATCCTT CAAGCTAATG AAGAATTGTG TCCAAAGAAG
TTGCTTCTGC CTAGTTCGAA AACTGTATCT TCGGGCACCA AAGAGCATTG TTATAATCAA
GTACCAGTTG AATTAAGTAC AGAGAAGAAG TCTAACTTGG AGAAGTTATA TTCTTATAAA
CCATGTGATA AGATTTCTTC TGGGAGTAAC ATTTCTAAAA AAAGTATCAT GGTACAGTCA
CCAGAAAAAG CTTACAGTTC CTCACAGCCT GTTATTTCGG CACAAGAGCA GGAGACTCAG
ATTGTGTTAT ATGGCAAATT GGTAGAAGCT AGGCAGAAAC ATGCCAATAA AATGGATGTT
CCCCCAGCTA TTCTGGCAAC AAACAAGATA CTGGTGGATA TGGCCAAAAT GAGACCAACT
ACGGTTGAAA ACGTAAAAAG GATTGATGGT GTTTCTGAAG GCAAAGCTGC CATGTTGGCC
CCTCTGTTGG AAGTCATCAA ACATTTCTGC CAAACAAATA GTGTTCAGAC AGACCTCTTT
TCAAGTACAA AACCTCAAGA AGAACAGAAG ACGAGTCTGG TAGCAAAAAA TAAAATATGC
ACACTTTCAC AGTCTATGGC CATCACATAC TCTTTATTCC AAGAAAAGAA GATGCCTTTG
AAGAGCATAG CTGAGAGCAG GATTCTGCCT CTCATGACAA TTGGCATGCA CTTATCCCAA
GCGGTGAAAG CTGGCTGCCC CCTTGATTTG GAGCGAGCAG GCCTGACTCC AGAGGTTCAG
AAGATTATTG CTGATGTTAT CCGAAACCCT CCCGTCAACT CAGATATGAG TAAAATTAGC
CTAATCAGAA TGTTAGTTCC TGAAAACATT GACACGTACC TTATCCACAT GGCAATTGAG
ATCCTTAAAC ATGGTCCTGA CAGCGGACTT CAACCTTCAT GTGATGTCAA CAAAAGGAGA
TGTTTTCCCG GTTCTGAAGA GATCTGTTCA AGTTCTAAGA GAAGCAAGGA AGAAGTAGGC
ATCAATACTG AGACTTCATC TGCAGAGAGA AAGAGACGAT TACCTGTGTG GTTTGCCAAA
GGAAGTGATA CCAGCAAGAA ATTAATGGAC AAAACGAAAA GGGGAGGTCT TTTTAGTTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu18809D
Sequence Information ORF Nucleotide Sequence (Length: 4299bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product Werner syndrome ATP-dependent helicase
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC084736.5, BP279291.1, AF091214.1 and AB209652.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2008 this sequence version replaced gi:110735438. Summary: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF091214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
ATGAGTGAAA AAAAATTGGA AACAACTGCA CAGCAGCGGA AATGTCCTGA ATGGATGAAT 
GTGCAGAATA AAAGATGTGC TGTAGAAGAA AGAAAGGCAT GTGTTCGGAA GAGTGTTTTT
GAAGATGACC TCCCCTTCTT AGAATTCACT GGATCCATTG TGTATAGTTA CGATGCTAGT
GATTGCTCTT TCCTGTCAGA AGATATTAGC ATGAGTCTAT CAGATGGGGA TGTGGTGGGA
TTTGACATGG AGTGGCCACC ATTATACAAT AGAGGGAAAC TTGGCAAAGT TGCACTAATT
CAGTTGTGTG TTTCTGAGAG CAAATGTTAC TTGTTCCACG TTTCTTCCAT GTCAGTTTTT
CCCCAGGGAT TAAAAATGTT GCTTGAAAAT AAAGCAGTTA AAAAGGCAGG TGTAGGAATT
GAAGGAGATC AGTGGAAACT TCTACGTGAC TTTGATATCA AATTGAAGAA TTTTGTGGAG
TTGACAGATG TTGCCAATAA AAAGCTGAAA TGCACAGAGA CCTGGAGCCT TAACAGTCTG
GTTAAACACC TCTTAGGTAA ACAGCTCCTG AAAGACAAGT CTATCCGCTG TAGCAATTGG
AGTAAATTTC CTCTCACTGA GGACCAGAAA CTGTATGCAG CCACTGATGC TTATGCTGGT
TTTATTATTT ACCGAAATTT AGAGATTTTG GATGATACTG TGCAAAGGTT TGCTATAAAT
AAAGAGGAAG AAATCCTACT TAGCGACATG AACAAACAGT TGACTTCAAT CTCTGAGGAA
GTGATGGATC TGGCTAAGCA TCTTCCTCAT GCTTTCAGTA AATTGGAAAA CCCACGGAGG
GTTTCTATCT TACTAAAGGA TATTTCAGAA AATCTATATT CACTGAGGAG GATGATAATT
GGGTCTACTA ACATTGAGAC TGAACTGAGG CCCAGCAATA ATTTAAACTT ATTATCCTTT
GAAGATTCAA CTACTGGGGG AGTACAACAG AAACAAATTA GAGAACATGA AGTTTTAATT
CACGTTGAAG ATGAAACATG GGACCCAACA CTTGATCATT TAGCTAAACA TGATGGAGAA
GATGTACTTG GAAATAAAGT GGAACGAAAA GAAGATGGAT TTGAAGATGG AGTAGAAGAC
AACAAATTGA AAGAGAATAT GGAAAGAGCT TGTTTGATGT CGTTAGATAT TACAGAACAT
GAACTCCAAA TTTTGGAACA GCAGTCTCAG GAAGAATATC TTAGTGATAT TGCTTATAAA
TCTACTGAGC ATTTATCTCC CAATGATAAT GAAAACGATA CGTCCTATGT AATTGAGAGT
GATGAAGATT TAGAAATGGA GATGCTTAAG CATTTATCTC CCAATGATAA TGAAAACGAT
ACGTCCTATG TAATTGAGAG TGATGAAGAT TTAGAAATGG AGATGCTTAA GTCTTTAGAA
AACCTCAATA GTGGCACGGT AGAACCAACT CATTCTAAAT GCTTAAAAAT GGAAAGAAAT
CTGGGTCTTC CTACTAAAGA AGAAGAAGAA GATGATGAAA ATGAAGCTAA TGAAGGGGAA
GAAGATGATG ATAAGGACTT TTTGTGGCCA GCACCCAATG AAGAGCAAGT TACTTGCCTC
AAGATGTACT TTGGCCATTC CAGTTTTAAA CCAGTTCAGT GGAAAGTGAT TCATTCAGTA
TTAGAAGAAA GAAGAGATAA TGTTGCTGTC ATGGCAACTG GATATGGAAA GAGTTTGTGC
TTCCAGTATC CACCTGTTTA TGTAGGCAAG ATTGGCCTTG TTATCTCTCC CCTTATTTCT
CTGATGGAAG ACCAAGTGCT ACAGCTTAAA ATGTCCAACA TCCCAGCTTG CTTCCTTGGA
TCAGCACAGT CAGAAAATGT TCTAACAGAT ATTAAATTAG GTAAATACCG GATTGTATAC
GTAACTCCAG AATACTGTTC AGGTAACATG GGCCTGCTCC AGCAACTTGA GGCTGATATT
GGTATCACGC TCATTGCTGT GGATGAGGCT CACTGTATTT CTGAGTGGGG GCATGATTTT
AGGGATTCAT TCAGGAAGTT GGGCTCCCTA AAGACAGCAC TGCCAATGGT TCCAATCGTT
GCACTTACTG CTACTGCAAG TTCTTCAATC CGGGAAGACA TTGTACGTTG CTTAAATCTG
AGAAATCCTC AGATCACCTG TACTGGTTTT GATCGACCAA ACCTGTATTT AGAAGTTAGG
CGAAAAACAG GGAATATCCT TCAGGATCTG CAGCCATTTC TTGTCAAAAC AAGTTCCCAC
TGGGAATTTG AAGGTCCAAC AATCATCTAC TGTCCTTCTA GAAAAATGAC ACAACAAGTT
ACAGGTGAAC TTAGGAAACT GAATCTATCC TGTGGAACAT ACCATGCGGG CATGAGTTTT
AGCACAAGGA AAGACATTCA TCATAGGTTT GTAAGAGATG AAATTCAGTG TGTCATAGCT
ACCATAGCTT TTGGAATGGG CATTAATAAA GCTGACATTC GCCAAGTCAT TCATTACGGT
GCTCCTAAGG ACATGGAATC ATATTATCAG GAGATTGGTA GAGCTGGTCG TGATGGACTT
CAAAGTTCTT GTCACGTCCT CTGGGCTCCT GCAGACATTA ACTTAAATAG GCACCTTCTT
ACTGAGATAC GTAATGAGAA GTTTCGATTA TACAAATTAA AGATGATGGC AAAGATGGAA
AAATATCTTC ATTCTAGCAG ATGTAGGAGA CAAATCATCT TGTCTCATTT TGAGGACAAA
CAAGTACAAA AAGCCTCCTT GGGAATTATG GGAACTGAAA AATGCTGTGA TAATTGCAGG
TCCAGATTGG ATCATTGCTA TTCCATGGAT GACTCAGAGG ATACATCCTG GGACTTTGGT
CCACAAGCAT TTAAGCTTTT GTCTGCTGTG GACATCTTAG GCGAAAAATT TGGAATTGGG
CTTCCAATTT TATTTCTCCG AGGATCTAAT TCTCAGCGTC TTGCCGATCA ATATCGCAGG
CACAGTTTAT TTGGCACTGG CAAGGATCAA ACAGAGAGTT GGTGGAAGGC TTTTTCCCGT
CAGCTGATCA CTGAGGGATT CTTGGTAGAA GTTTCTCGGT ATAACAAATT TATGAAGATT
TGCGCCCTTA CGAAAAAGGG TAGAAATTGG CTTCATAAAG CTAATACAGA ATCTCAGAGC
CTCATCCTTC AAGCTAATGA AGAATTGTGT CCAAAGAAGT TGCTTCTGCC TAGTTCGAAA
ACTGTATCTT CGGGCACCAA AGAGCATTGT TATAATCAAG TACCAGTTGA ATTAAGTACA
GAGAAGAAGT CTAACTTGGA GAAGTTATAT TCTTATAAAC CATGTGATAA GATTTCTTCT
GGGAGTAACA TTTCTAAAAA AAGTATCATG GTACAGTCAC CAGAAAAAGC TTACAGTTCC
TCACAGCCTG TTATTTCGGC ACAAGAGCAG GAGACTCAGA TTGTGTTATA TGGCAAATTG
GTAGAAGCTA GGCAGAAACA TGCCAATAAA ATGGATGTTC CCCCAGCTAT TCTGGCAACA
AACAAGATAC TGGTGGATAT GGCCAAAATG AGACCAACTA CGGTTGAAAA CGTAAAAAGG
ATTGATGGTG TTTCTGAAGG CAAAGCTGCC ATGTTGGCCC CTCTGTTGGA AGTCATCAAA
CATTTCTGCC AAACAAATAG TGTTCAGACA GACCTCTTTT CAAGTACAAA ACCTCAAGAA
GAACAGAAGA CGAGTCTGGT AGCAAAAAAT AAAATATGCA CACTTTCACA GTCTATGGCC
ATCACATACT CTTTATTCCA AGAAAAGAAG ATGCCTTTGA AGAGCATAGC TGAGAGCAGG
ATTCTGCCTC TCATGACAAT TGGCATGCAC TTATCCCAAG CGGTGAAAGC TGGCTGCCCC
CTTGATTTGG AGCGAGCAGG CCTGACTCCA GAGGTTCAGA AGATTATTGC TGATGTTATC
CGAAACCCTC CCGTCAACTC AGATATGAGT AAAATTAGCC TAATCAGAAT GTTAGTTCCT
GAAAACATTG ACACGTACCT TATCCACATG GCAATTGAGA TCCTTAAACA TGGTCCTGAC
AGCGGACTTC AACCTTCATG TGATGTCAAC AAAAGGAGAT GTTTTCCCGG TTCTGAAGAG
ATCTGTTCAA GTTCTAAGAG AAGCAAGGAA GAAGTAGGCA TCAATACTGA GACTTCATCT
GCAGAGAGAA AGAGACGATT ACCTGTGTGG TTTGCCAAAG GAAGTGATAC CAGCAAGAAA
TTAATGGACA AAACGAAAAG GGGAGGTCTT TTTAGTTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000544.2
CDS789..5087
Misc Feature(1)774..776(+)
Misc Feature(2)792..1619(+)
Misc Feature(3)792..794(+)
Misc Feature(4)969..1475(+)
Misc Feature(5)1032..1436(+)
Misc Feature(6)1032..1436(+)
Misc Feature(7)1035..1436(+)
Misc Feature(8)1221..1223(+)
Misc Feature(9)2058..2219(+)
Misc Feature(10)2064..2066(+)
Misc Feature(11)2106..2108(+)
Misc Feature(12)2145..2147(+)
Misc Feature(13)2187..2189(+)
Misc Feature(14)2400..3818(+)
Misc Feature(15)2481..2903(+)
Misc Feature(16)2508..2522(+)
Misc Feature(17)2790..2801(+)
Misc Feature(18)2790..2801(+)
Misc Feature(19)3063..3389(+)
Misc Feature(20)3102..3257(+)
Misc Feature(21)3273..3359(+)
Misc Feature(22)3660..3941(+)
Misc Feature(23)3747..3767(+)
Misc Feature(24)3897..3899(+)
Misc Feature(25)3960..3962(+)
Misc Feature(26)4185..4187(+)
Misc Feature(27)4209..4211(+)
Misc Feature(28)4254..4475(+)
Misc Feature(29)4557..4844(+)
Misc Feature(30)4662..4664(+)
Exon (1)1..712
Gene:WRN
Gene Synonym:
Exon (2)713..884
Gene:WRN
Gene Synonym:
Exon (3)885..997
Gene:WRN
Gene Synonym:
Exon (4)998..1143
Gene:WRN
Gene Synonym:
Exon (5)1144..1292
Gene:WRN
Gene Synonym:
Exon (6)1293..1442
Gene:WRN
Gene Synonym:
Exon (7)1443..1512
Gene:WRN
Gene Synonym:
Exon (8)1513..1627
Gene:WRN
Gene Synonym:
Exon (9)1628..2057
Gene:WRN
Gene Synonym:
Exon (10)2058..2138
Gene:WRN
Gene Synonym:
Exon (11)2139..2219
Gene:WRN
Gene Synonym:
Exon (12)2220..2364
Gene:WRN
Gene Synonym:
Exon (13)2365..2440
Gene:WRN
Gene Synonym:
Exon (14)2441..2508
Gene:WRN
Gene Synonym:
Exon (15)2509..2617
Gene:WRN
Gene Synonym:
Exon (16)2618..2686
Gene:WRN
Gene Synonym:
Exon (17)2687..2769
Gene:WRN
Gene Synonym:
Exon (18)2770..2876
Gene:WRN
Gene Synonym:
Exon (19)2877..3061
Gene:WRN
Gene Synonym:
Exon (20)3062..3236
Gene:WRN
Gene Synonym:
Exon (21)3237..3418
Gene:WRN
Gene Synonym:
Exon (22)3419..3520
Gene:WRN
Gene Synonym:
Exon (23)3521..3613
Gene:WRN
Gene Synonym:
Exon (24)3614..3755
Gene:WRN
Gene Synonym:
Exon (25)3756..3926
Gene:WRN
Gene Synonym:
Exon (26)3927..4021
Gene:WRN
Gene Synonym:
Exon (27)4022..4097
Gene:WRN
Gene Synonym:
Exon (28)4098..4171
Gene:WRN
Gene Synonym:
Exon (29)4172..4247
Gene:WRN
Gene Synonym:
Exon (30)4248..4360
Gene:WRN
Gene Synonym:
Exon (31)4361..4475
Gene:WRN
Gene Synonym:
Exon (32)4476..4607
Gene:WRN
Gene Synonym:
Exon (33)4608..4770
Gene:WRN
Gene Synonym:
Exon (34)4771..4979
Gene:WRN
Gene Synonym:
Exon (35)4980..5746
Gene:WRN
Gene Synonym:
Translation
Position Chain Variation Link
70 70 c, g dbSNP:558022122
75 75 a, g dbSNP:369167366
90 90 c, g dbSNP:578121063
158 158 c, g dbSNP:10112017
171 171 c, g dbSNP:7017069
184 184 a, c dbSNP:11574155
200 200 c, t dbSNP:543017223
233 233 c, t dbSNP:559815612
268 268 g, t dbSNP:528540025
270 270 a, c dbSNP:545194854
289 289 c, t dbSNP:564980452
304 304 a, t dbSNP:375149892
313 313 c, t dbSNP:777640941
374 374 a, g dbSNP:749467037
381 381 c, t dbSNP:11574156
415 415 g, t dbSNP:567202018
425 425 a, t dbSNP:529655264
511 511 c, g dbSNP:11574157
515 515 -, g dbSNP:5890546
525 525 g, t dbSNP:369873912
547 547 a, t dbSNP:566565869
576 576 a, g dbSNP:11574158
589 589 c, t dbSNP:778938665
592 592 a, c, t dbSNP:11574159
601 601 a, g dbSNP:753342861
610 610 c, t dbSNP:754522897
626 626 c, g dbSNP:11574160
645 645 g, t dbSNP:537618726
705 705 c, t dbSNP:188087758
738 738 c, t dbSNP:187869929
741 741 c, t dbSNP:193031348
743 743 c, g dbSNP:774377745
752 752 a, g dbSNP:370014019
763 763 a, g dbSNP:763753170
765 765 c, t dbSNP:753595348
796 796 -, a dbSNP:745681892
800 800 a, g dbSNP:761784221
804 804 a, c, t dbSNP:202148988
813 813 a, g dbSNP:757791580
821 821 a, g dbSNP:756255418
825 825 c, t dbSNP:373503267
830 830 a, g dbSNP:3087420
861 861 a, g dbSNP:754627643
862 862 g, t dbSNP:781459943
863 863 a, g dbSNP:150524008
865 865 a, g dbSNP:550926459
867 867 a, g dbSNP:778355874
870 870 a, g dbSNP:538314935
883 883 a, g dbSNP:34477820
884 884 -, g dbSNP:755891046
887 887 a, g dbSNP:753114305
892 892 c, t dbSNP:538178496
894 894 c, t dbSNP:141495269
895 895 a, g dbSNP:34084741
899 899 c, g dbSNP:771433734
902 902 c, t dbSNP:201800431
917 917 c, t dbSNP:201590676
918 918 c, g dbSNP:139775895
923 923 -, ctt dbSNP:768226589
925 925 c, t dbSNP:772246871
931 931 a, g dbSNP:775635001
932 932 a, g dbSNP:145959045
933 933 a, t dbSNP:587778749
945 945 a, g dbSNP:772963859
948 948 a, g dbSNP:762851957
959 959 c, t dbSNP:373806031
960 960 a, g dbSNP:773803207
964 964 c, t dbSNP:759022881
966 966 a, g dbSNP:767288688
970 970 a, g dbSNP:752345825
985 985 c, t dbSNP:756575284
989 989 a, g dbSNP:764589321
1007 1007 a, g dbSNP:566693857
1013 1013 -, g dbSNP:747587698
1017 1017 c, g dbSNP:144670883
1029 1029 c, t dbSNP:760452488
1047 1047 -, c dbSNP:773717744
1058 1058 c, t dbSNP:148758902
1064 1064 a, g dbSNP:754221635
1077 1077 a, g dbSNP:757573403
1091 1091 a, g dbSNP:765687541
1092 1092 c, t dbSNP:750903457
1101 1101 -, tc dbSNP:760991758
1103 1103 c, t dbSNP:758873256
1110 1110 a, c dbSNP:780157148
1114 1114 a, g dbSNP:142346721
1115 1115 c, g, t dbSNP:371538747
1116 1116 -, a dbSNP:766733097
1118 1118 c, t dbSNP:749053792
1127 1127 c, t dbSNP:374898432
1128 1128 a, g dbSNP:2230009
1137 1137 a, g dbSNP:768216398
1138 1138 c, t dbSNP:772108759
1150 1150 c, g dbSNP:768174465
1151 1151 c, g dbSNP:372942234
1161 1161 a, g dbSNP:267607007
1163 1163 a, t dbSNP:387906337
1191 1191 a, g dbSNP:267607008
1194 1194 a, g dbSNP:17847582
1208 1208 g, t dbSNP:548061402
1209 1209 a, g dbSNP:769317785
1217 1217 c, t dbSNP:773697397
1219 1219 a, g dbSNP:771444804
1220 1220 a, g dbSNP:766887542
1224 1224 a, c, g dbSNP:752014453
1230 1230 c, g dbSNP:767673195
1231 1231 a, t dbSNP:587778753
1233 1233 c, t dbSNP:752693894
1234 1234 a, c, g dbSNP:61761625
1240 1240 a, t dbSNP:200456571
1254 1254 a, c, g dbSNP:758208189
1260 1260 c, t dbSNP:746985833
1273 1273 c, t dbSNP:147661728
1274 1274 a, g dbSNP:141480904
1275 1275 g, t dbSNP:368717487
1276 1276 a, t dbSNP:769495252
1285 1285 a, g dbSNP:772797243
1287 1287 -, aa dbSNP:776785728
1287 1287 a, g dbSNP:749679346
1301 1301 c, t dbSNP:1800389
1302 1302 a, c dbSNP:367991517
1303 1303 a, c dbSNP:777437332
1312 1312 -, g dbSNP:752830087
1315 1315 g, t dbSNP:748976035
1324 1324 a, g dbSNP:770545798
1330 1330 c, t dbSNP:774751582
1336 1336 a, g dbSNP:746210769
1337 1337 c, t dbSNP:772637078
1349 1349 a, g dbSNP:775802030
1363 1363 a, g dbSNP:760829035
1364 1364 c, g dbSNP:771397499
1367 1367 a, g dbSNP:764227749
1369 1369 c, t dbSNP:776831463
1371 1371 a, g dbSNP:371736282
1374 1374 c, t dbSNP:375762379
1375 1375 a, g dbSNP:561603992
1376 1376 a, c dbSNP:759197788
1389 1389 a, g dbSNP:767516095
1398 1398 c, t dbSNP:199644081
1401 1401 c, g dbSNP:756050193
1407 1407 c, g dbSNP:777311042
1414 1414 a, g dbSNP:753330899
1416 1416 a, c dbSNP:138037385
1423 1423 a, g dbSNP:756966886
1429 1429 c, g dbSNP:778470570
1433 1433 a, t dbSNP:746256937
1434 1434 c, g dbSNP:772273549
1441 1441 a, g dbSNP:780640173
1442 1442 c, t dbSNP:747520883
1448 1448 g, t dbSNP:756697581
1452 1452 a, t dbSNP:201902936
1454 1454 c, t dbSNP:376622928
1455 1455 a, g, t dbSNP:587778754
1461 1461 c, t dbSNP:370324188
1462 1462 a, g dbSNP:62506077
1464 1464 a, c dbSNP:143088402
1488 1488 c, g dbSNP:769291583
1503 1503 a, g dbSNP:781741859
1508 1508 g, t dbSNP:148229804
1512 1512 a, c, g dbSNP:769959338
1526 1526 a, c dbSNP:141615988
1532 1532 c, t dbSNP:370071444
1533 1533 a, g dbSNP:758055295
1535 1535 a, c dbSNP:374142752
1536 1536 a, g dbSNP:767793936
1542 1542 a, c dbSNP:751986285
1568 1568 a, g dbSNP:776183892
1572 1572 a, g dbSNP:781773383
1577 1577 c, t dbSNP:748707126
1584 1584 a, g dbSNP:756669569
1597 1597 a, c dbSNP:777770937
1618 1618 a, c dbSNP:749379604
1622 1622 a, g, t dbSNP:527842476
1623 1623 c, t dbSNP:199923241
1624 1624 a, g dbSNP:768400363
1625 1625 c, g dbSNP:113672137
1627 1627 c, g dbSNP:761786255
1634 1634 c, t dbSNP:772258462
1635 1635 a, g dbSNP:201643901
1638 1638 g, t dbSNP:747871633
1639 1639 c, t dbSNP:769634887
1640 1640 a, g dbSNP:146197312
1643 1643 a, g dbSNP:762404436
1648 1648 a, g dbSNP:770517898
1650 1650 a, g dbSNP:773980642
1653 1653 -, tcagaaaa dbSNP:752312589
1664 1664 a, g dbSNP:759323644
1668 1668 a, t dbSNP:376219460
1672 1672 c, t dbSNP:767270343
1681 1681 c, t dbSNP:753112277
1683 1683 -, t dbSNP:757968518
1684 1684 c, t dbSNP:761040399
1691 1691 a, g dbSNP:747226837
1693 1693 c, t dbSNP:754329517
1700 1700 -, c dbSNP:777323239
1709 1709 -, tg dbSNP:746445847
1730 1730 c, t dbSNP:757672816
1737 1737 -, tta dbSNP:771474603
1749 1749 g, t dbSNP:779012596
1756 1756 c, t dbSNP:369277330
1758 1758 a, g dbSNP:1800390
1765 1765 a, g dbSNP:143068173
1772 1772 a, g dbSNP:201979783
1774 1774 a, c, g dbSNP:4987237
1779 1779 a, g dbSNP:777402254
1786 1786 g, t dbSNP:530437272
1793 1793 a, t dbSNP:770764781
1795 1795 a, g dbSNP:774075901
1800 1800 a, g dbSNP:759046519
1806 1806 a, g dbSNP:771859604
1808 1808 a, t dbSNP:775231592
1811 1811 c, t dbSNP:760975157
1812 1812 a, g dbSNP:764559021
1813 1813 c, t dbSNP:181033722
1815 1815 a, g dbSNP:11574222
1834 1834 c, t dbSNP:765667470
1855 1855 a, g dbSNP:556227294
1858 1858 a, g dbSNP:372907716
1861 1861 a, g dbSNP:780287000
1869 1869 g, t dbSNP:751850825
1872 1872 a, g dbSNP:755136292
1874 1874 a, g dbSNP:777685918
1881 1881 a, c dbSNP:749035826
1888 1888 c, t dbSNP:576284026
1893 1893 c, t dbSNP:17847577
1906 1906 g, t dbSNP:376913063
1909 1909 -, ttc dbSNP:781511385
1911 1911 c, g dbSNP:745391184
1933 1933 a, g dbSNP:541455377
1937 1937 g, t dbSNP:4987238
1943 1943 a, g dbSNP:2230010
1943 1943 a, g dbSNP:386561765
1947 1947 a, g dbSNP:370136100
1949 1949 a, g dbSNP:1800391
1951 1951 -, a dbSNP:558267186
1955 1955 a, c dbSNP:762026460
1960 1960 g, t dbSNP:145445994
1962 1962 a, t dbSNP:773671411
1968 1968 c, t dbSNP:75632545
1969 1969 c, g, t dbSNP:200487813
1970 1970 a, g dbSNP:138565529
1975 1975 a, g dbSNP:755298910
1977 1977 a, g dbSNP:767571801
1980 1980 a, g dbSNP:532554615
1985 1985 a, c dbSNP:748158243
1987 1987 a, g dbSNP:757065467
1992 1992 c, g dbSNP:779022285
1994 1994 c, t dbSNP:745838198
2009 2009 a, g dbSNP:758386387
2010 2010 a, c dbSNP:779671852
2024 2024 a, g dbSNP:746496708
2028 2028 c, g dbSNP:587778755
2035 2035 a, g dbSNP:560922465
2044 2044 a, c dbSNP:776098344
2048 2048 a, g dbSNP:748544713
2052 2052 a, c dbSNP:770185829
2055 2055 a, g dbSNP:773546749
2063 2063 a, g dbSNP:771486771
2071 2071 a, g dbSNP:774668851
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