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YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta [Homo sapiens (human)]

Gene Symbol YWHAH
Entrez Gene ID 7533
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Synonyms YWHA1
General protein information
Preferred Names
14-3-3 protein eta
Names
14-3-3 protein eta
14-3-3 eta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q12.3

Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]. lac of sum
Disorder MIM:

113508

Disorder Html:





The following YWHAH gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the YWHAH gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu29420 NM_003405 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu29420
Accession Version NM_003405.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 741bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu29420D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product 14-3-3 protein eta
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z82248.1, BC003047.1 and AY007132.1. On Mar 24, 2005 this sequence version replaced gi:21464102. Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003047.1, S80794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA
GAAGCAGGAG AAGGCAACTG A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003396.1
CDS242..982
Misc Feature(1)209..211(+)
Misc Feature(2)245..247(+)
Misc Feature(3)245..247(+)
Misc Feature(4)248..964(+)
Misc Feature(5)269..517(+)
Misc Feature(6)314..316(+)
Misc Feature(7)389..928(+)
Misc Feature(8)410..412(+)
Misc Feature(9)416..418(+)
Misc Feature(10)635..637(+)
Exon (1)1..328
Gene:YWHAH
Gene Synonym:
Exon (2)329..1793
Gene:YWHAH
Gene Synonym:
Translation
Position Chain Variation Link
70 70 a, g dbSNP:557843353
81 81 c, t dbSNP:571378044
84 84 c, t dbSNP:534015195
86 86 c, t dbSNP:554180567
88 88 -, gcctgca dbSNP:71697452
94 94 -, gcctgca dbSNP:758069981
106 106 -, gcagcct dbSNP:80248435
126 126 a, g dbSNP:573950800
128 128 g, t dbSNP:536956116
129 129 c, g dbSNP:556539407
138 138 c, g dbSNP:576593511
149 149 c, t dbSNP:184614680
172 172 c, t dbSNP:565455707
181 181 c, t dbSNP:11539380
202 202 -, a dbSNP:755526658
220 220 g, t dbSNP:11539379
244 244 -, ggg dbSNP:779321639
250 250 c, t dbSNP:747723196
269 269 c, g dbSNP:771708125
354 354 c, t dbSNP:749981631
357 357 a, g dbSNP:148198776
361 361 a, t dbSNP:779744773
367 367 a, c dbSNP:376719456
373 373 c, g dbSNP:758808807
380 380 c, g dbSNP:777955407
410 410 c, t dbSNP:747585534
418 418 c, g dbSNP:61752252
432 432 a, g dbSNP:371520759
447 447 a, g dbSNP:200741786
460 460 c, t dbSNP:746003960
465 465 a, g dbSNP:769990372
466 466 c, t dbSNP:775786720
467 467 a, g dbSNP:763036574
475 475 a, g dbSNP:768526326
484 484 a, g dbSNP:201984741
497 497 a, c dbSNP:761643647
504 504 a, g dbSNP:767498575
507 507 c, t dbSNP:568392674
508 508 c, t dbSNP:760179452
514 514 c, g dbSNP:765821071
517 517 a, g dbSNP:753554467
537 537 a, t dbSNP:754548953
550 550 a, g dbSNP:764915437
556 556 c, t dbSNP:751039885
565 565 a, g dbSNP:751919287
568 568 c, t dbSNP:757684882
571 571 g, t dbSNP:11539378
579 579 a, g dbSNP:781781497
591 591 a, g dbSNP:746311458
601 601 a, g dbSNP:756283317
602 602 c, g dbSNP:761060110
625 625 c, t dbSNP:766851218
652 652 c, t dbSNP:749354982
657 657 c, g dbSNP:150273100
660 660 a, g dbSNP:768808599
665 665 a, g dbSNP:774617044
668 668 -, a dbSNP:145603750
670 670 a, g dbSNP:78051162
679 679 g, t dbSNP:771784106
683 683 a, g dbSNP:773143527
687 687 c, g dbSNP:760561469
730 730 a, c, g dbSNP:765949241
731 731 a, c dbSNP:759067894
744 744 c, t dbSNP:764857679
745 745 a, g dbSNP:8192635
752 752 a, g dbSNP:367752222
756 756 a, g dbSNP:537326257
756 756 -, g dbSNP:765403118
757 757 a, g dbSNP:750997440
781 781 c, t dbSNP:756725733
792 792 a, g dbSNP:780586701
809 809 c, t dbSNP:554213754
814 814 a, g dbSNP:749382258
817 817 a, g dbSNP:755078335
820 820 c, t dbSNP:779002920
823 823 c, t dbSNP:748307630
824 824 c, g, t dbSNP:771880344
844 844 c, t dbSNP:746778385
847 847 a, c, t dbSNP:770826115
849 849 a, c dbSNP:759037761
865 865 a, g dbSNP:113715410
868 868 c, t dbSNP:769282289
871 871 a, g dbSNP:775297184
877 877 c, t dbSNP:754047554
885 885 c, t dbSNP:75617813
901 901 a, g dbSNP:35621275
902 902 c, t dbSNP:750865274
914 914 c, t dbSNP:369393668
928 928 c, t dbSNP:766860181
931 931 a, c dbSNP:754302886
942 942 c, t dbSNP:201532069
946 946 c, t dbSNP:377641891
954 954 a, g dbSNP:778998997
964 964 a, g dbSNP:139643031
970 970 a, g dbSNP:758664704
985 985 a, g dbSNP:78386008
994 994 a, g dbSNP:1049583
996 996 c, t dbSNP:770757162
999 999 c, g, t dbSNP:80295425
1001 1001 a, g dbSNP:2858755
1003 1003 c, t dbSNP:769211259
1004 1004 a, c dbSNP:775180236
1006 1006 g, t dbSNP:373594195
1007 1007 c, t dbSNP:376992185
1010 1010 c, t dbSNP:774141438
1012 1012 c, t dbSNP:370005433
1015 1015 -, cca dbSNP:774489663
1026 1026 a, t dbSNP:372639562
1034 1034 c, t dbSNP:754319923
1037 1037 c, t dbSNP:535486217
1060 1060 a, g dbSNP:536785227
1074 1074 a, t dbSNP:553190974
1077 1077 c, t dbSNP:758539087
1102 1102 c, g dbSNP:555329579
1145 1145 c, t dbSNP:765758198
1150 1150 a, g dbSNP:777672490
1186 1186 a, c dbSNP:746963961
1230 1230 a, g dbSNP:575576344
1238 1238 a, g dbSNP:544498051
1244 1244 -, g dbSNP:755773565
1348 1348 a, g dbSNP:573218026
1350 1350 g, t dbSNP:186550345
1356 1356 c, g dbSNP:745477298
1380 1380 c, t dbSNP:192602237
1415 1415 a, g dbSNP:751714633
1456 1456 a, c, g dbSNP:763306435
1464 1464 c, g dbSNP:769313403
1492 1492 c, t dbSNP:370416947
1513 1513 c, t dbSNP:185384904
1541 1541 a, g dbSNP:148616662
1550 1550 c, t dbSNP:528172644
1585 1585 c, t dbSNP:115884522
1589 1589 g, t dbSNP:561664665
1593 1593 -, t dbSNP:541365242
1594 1594 -, t dbSNP:775811152
1594 1594 c, t dbSNP:539195869
1595 1595 -, t dbSNP:34145379
1601 1601 -, t dbSNP:71697808
1608 1608 -, t dbSNP:398036900
1608 1608 g, t dbSNP:77289669
1610 1610 g, t dbSNP:62240587
1611 1611 g, t dbSNP:1049816
1680 1680 a, c dbSNP:142094943
1682 1682 c, t dbSNP:577881199
1696 1696 -, c dbSNP:34122600
1700 1700 a, g dbSNP:775252892
1711 1711 c, g dbSNP:752052745
1738 1738 c, t dbSNP:1049865
1742 1742 a, g dbSNP:762367675
1763 1763 c, t dbSNP:188688583

Target ORF information:

RefSeq Version NM_003405
Organism Homo sapiens (human)
Definition Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003405

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGGGGACC GGGAGCAGCT GCTGCAGCGG GCGCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGACATGG CCTCCGCTAT GAAGGCGGTG ACAGAGCTGA ATGAACCTCT CTCCAATGAA
GATCGAAATC TCCTCTCTGT GGCCTACAAG AATGTGGTTG GTGCCAGGCG ATCTTCCTGG
AGGGTCATTA GCAGCATTGA GCAGAAAACC ATGGCTGATG GAAACGAAAA GAAATTGGAG
AAAGTTAAAG CTTACCGGGA GAAGATTGAG AAGGAGCTGG AGACAGTTTG CAATGATGTC
CTGTCTCTGC TTGACAAGTT CCTGATCAAG AACTGCAATG ATTTCCAGTA TGAGAGCAAG
GTGTTTTACC TGAAAATGAA GGGTGATTAC TACCGCTACT TAGCAGAGGT CGCTTCTGGG
GAGAAGAAAA ACAGTGTGGT CGAAGCTTCT GAAGCTGCCT ACAAGGAAGC CTTTGAAATC
AGCAAAGAGC AGATGCAACC CACGCATCCC ATCCGGCTGG GCCTGGCCCT CAACTTCTCC
GTGTTCTACT ATGAGATCCA GAATGCACCT GAGCAAGCCT GCCTCTTAGC CAAACAAGCC
TTCGATGATG CCATAGCTGA GCTGGACACA CTAAACGAGG ATTCCTATAA GGACTCCACG
CTGATCATGC AGTTGCTGCG AGACAACCTC ACCCTCTGGA CGAGCGACCA GCAGGATGAA
GAAGCAGGAG AAGGCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.