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ZIC3 Zic family member 3 [Homo sapiens (human)]

Gene Symbol ZIC3
Entrez Gene ID 7547
Full Name Zic family member 3
Synonyms HTX, HTX1, VACTERLX, ZNF203
General protein information
Preferred Names
zinc finger protein ZIC 3
Names
zinc finger protein ZIC 3
heterotaxy 1
zinc finger protein 203
zinc finger protein of the cerebellum 3
Zic family member 3 (odd-paired homolog, Drosophila)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq26.2

Summary This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300265

Disorder Html: Heterotaxy, visceral, 1, X-linked 306955 (3); Congenital heart





The following ZIC3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZIC3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18212 NM_003413 Homo sapiens Zic family member 3 (ZIC3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18212
Accession Version NM_003413.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1404bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product zinc finger protein ZIC 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL035443.4. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2008 this sequence version replaced gi:22547199. Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF028706.1, EU532020.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGACGATGC TCCTGGACGG AGGCCCGCAG TTCCCTGGGC TGGGAGTGGG CAGCTTCGGC 
GCGCCGCGCC ACCACGAGAT GCCCAACCGT GAGCCGGCAG GCATGGGGCT GAATCCCTTC
GGGGACTCAA CCCACGCCGC CGCCGCCGCC GCCGCCGCCG CTGCCTTCAA GCTGAGCCCT
GCCGCGGCGC ACGATCTATC TTCAGGCCAG AGCTCGGCTT TCACGCCGCA GGGTTCGGGC
TACGCCAACG CCCTGGGCCA CCATCACCAC CACCATCACC ATCATCACCA CACCAGCCAG
GTGCCCAGCT ACGGTGGCGC TGCCTCTGCC GCCTTCAACT CAACGCGCGA GTTTCTGTTC
CGCCAGCGCA GCTCCGGGCT CAGTGAGGCG GCCTCGGGTG GCGGGCAGCA CGGGCTCTTC
GCCGGCTCGG CGAGCAGCCT GCATGCTCCA GCTGGCATCC CCGAGCCCCC TAGCTACTTG
CTGTTTCCCG GGCTGCATGA GCAGGGCGCT GGGCACCCGT CGCCCACAGG GCACGTGGAC
AACAACCAGG TCCACCTGGG GCTGCGTGGG GAGCTGTTCG GCCGTGCTGA CCCATACCGC
CCAGTGGCCA GCCCGCGCAC GGACCCCTAC GCGGCCGGCG CTCAGTTTCC TAACTACAGC
CCCATGAACA TGAACATGGG AGTGAACGTG GCGGCCCACC ACGGGCCCGG CGCCTTCTTC
CGTTATATGC GGCAGCCTAT CAAGCAGGAG CTGTCGTGCA AGTGGATCGA CGAGGCTCAG
CTGAGCCGGC CCAAGAAGAG CTGCGACCGG ACCTTCAGCA CCATGCATGA GCTGGTGACA
CATGTCACCA TGGAGCATGT GGGGGGCCCG GAGCAGAACA ACCACGTCTG CTACTGGGAG
GAGTGCCCCC GGGAGGGCAA GTCTTTCAAG GCGAAGTACA AACTGGTCAA CCACATCCGA
GTGCACACGG GCGAGAAGCC CTTCCCATGC CCCTTCCCGG GCTGCGGGAA GATCTTTGCC
CGTTCTGAGA ACCTCAAGAT CCACAAGAGG ACCCACACAG GTGAGAAACC TTTCAAATGT
GAATTTGAAG GCTGTGACAG ACGCTTTGCC AACAGCAGCG ACCGTAAGAA GCACATGCAT
GTGCATACCT CGGACAAGCC CTATATCTGC AAAGTGTGCG ACAAGTCCTA CACGCACCCG
AGCTCCCTGC GCAAACACAT GAAGGTTCAT GAATCTCAAG GGTCAGATTC CTCCCCTGCT
GCCAGTTCAG GCTATGAATC TTCCACTCCA CCCGCTATAG CTTCTGCAAA CAGTAAAGAT
ACCACTAAAA CCCCTTCTGC AGTTCAAACT AGCACCAGCC ACAACCCTGG ACTTCCTCCT
AATTTTAACG AATGGTACGT CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003404.1
CDS506..1909
Misc Feature(1)236..238(+)
Misc Feature(2)1394..1471(+)
Misc Feature(3)1409..1471(+)
Misc Feature(4)1409..1471(+)
Misc Feature(5)1424..1648(+)
Misc Feature(6)1448..1528(+)
Misc Feature(7)1493..1561(+)
Misc Feature(8)1493..1561(+)
Misc Feature(9)1493..1558(+)
Misc Feature(10)1535..1618(+)
Misc Feature(11)1583..1651(+)
Misc Feature(12)1583..1651(+)
Misc Feature(13)1592..1651(+)
Misc Feature(14)1598..1651(+)
Misc Feature(15)1604..1732(+)
Misc Feature(16)1625..1702(+)
Misc Feature(17)1667..1735(+)
Misc Feature(18)1673..1735(+)
Misc Feature(19)1673..1735(+)
Exon (1)1..1565
Gene:ZIC3
Gene Synonym:
Exon (2)1566..1729
Gene:ZIC3
Gene Synonym:
Exon (3)1730..3939
Gene:ZIC3
Gene Synonym:
Translation
Position Chain Variation Link
2 2 c, t dbSNP:776236586
78 78 a, c, t dbSNP:529515809
171 171 c, t dbSNP:181414932
217 217 c, t dbSNP:750446491
311 311 c, t dbSNP:758408698
421 421 c, t dbSNP:766240527
436 436 a, g dbSNP:749818500
456 456 g, t dbSNP:777529417
458 458 -, c dbSNP:759794590
485 485 c, t dbSNP:746705684
487 487 c, t dbSNP:770620335
489 489 c, g dbSNP:776090175
492 492 a, t dbSNP:745406810
500 500 a, c dbSNP:751292937
519 519 c, t dbSNP:776181924
524 524 a, g dbSNP:763534805
531 531 c, g dbSNP:764613910
534 534 a, t dbSNP:771361451
540 540 a, c dbSNP:774855618
549 549 c, g dbSNP:762020217
554 554 g, t dbSNP:147232392
580 580 c, g dbSNP:61735157
587 587 c, t dbSNP:756255074
594 594 c, g dbSNP:766420888
597 597 a, t dbSNP:752686913
598 598 c, g dbSNP:758325909
601 601 a, g dbSNP:777619649
602 602 g, t dbSNP:746833203
603 603 c, t dbSNP:201398331
608 608 a, g dbSNP:780929975
636 636 c, g dbSNP:78870836
640 640 -, cgccgccgccgc dbSNP:757778290
640 640 -, cgccgccgc dbSNP:749833589
640 640 -, cgccgc dbSNP:777825604
640 640 -, cgc dbSNP:748325646
640 640 c, t dbSNP:769479561
642 642 -, cgc dbSNP:772947913
646 646 c, t dbSNP:771406033
653 653 c, g dbSNP:749880079
658 658 -, gccgccgct dbSNP:767851433
661 661 a, c dbSNP:769295569
662 662 -, gccgct dbSNP:766950526
665 665 -, gct dbSNP:749955088
667 667 c, t dbSNP:62637689
670 670 -, gccgcc dbSNP:398122850
671 671 -, ttcaa dbSNP:755738453
721 721 c, g dbSNP:762264614
729 729 a, c dbSNP:772291510
757 757 c, t dbSNP:746180463
775 775 c, t dbSNP:369721947
793 793 c, t dbSNP:776092045
810 810 c, t dbSNP:766511169
813 813 a, g dbSNP:753919160
824 824 a, g dbSNP:759553920
831 831 c, g dbSNP:373628598
873 873 a, g dbSNP:751413121
902 902 a, g dbSNP:757117094
925 925 c, t dbSNP:761546254
931 931 c, t dbSNP:750150672
934 934 c, g dbSNP:755825923
944 944 c, t dbSNP:375943285
950 950 a, g dbSNP:769498242
967 967 a, c dbSNP:772820536
970 970 a, g dbSNP:768237552
977 977 a, g dbSNP:779510281
996 996 a, g dbSNP:748579579
1000 1000 g, t dbSNP:772542926
1018 1018 a, g, t dbSNP:370048935
1028 1028 c, g dbSNP:763037926
1031 1031 a, g dbSNP:771154908
1039 1039 c, g dbSNP:776785233
1060 1060 c, t dbSNP:766184012
1062 1062 c, t dbSNP:765201397
1066 1066 c, g dbSNP:751566306
1088 1088 c, g dbSNP:761644167
1102 1102 c, t dbSNP:769300030
1103 1103 a, c dbSNP:767415936
1112 1112 a, g dbSNP:140823819
1119 1119 c, g dbSNP:755920134
1135 1135 c, t dbSNP:779878257
1144 1144 a, c dbSNP:200655438
1146 1146 c, t dbSNP:754581917
1154 1154 c, g dbSNP:104894963
1156 1156 c, t dbSNP:748754678
1162 1162 c, t dbSNP:767327756
1166 1166 c, g dbSNP:758831851
1167 1167 -, catgaa dbSNP:779610526
1181 1181 a, c dbSNP:778283887
1187 1187 a, g dbSNP:373327450
1191 1191 a, c, g dbSNP:771246553
1197 1197 c, g dbSNP:746070565
1198 1198 a, g dbSNP:752982874
1216 1216 c, g dbSNP:756295103
1231 1231 c, t dbSNP:147483234
1244 1244 a, g dbSNP:377356678
1250 1250 c, t dbSNP:104894960
1256 1256 c, t dbSNP:767373338
1262 1262 a, t dbSNP:122463167
1263 1263 c, g dbSNP:104894961
1268 1268 g, t dbSNP:122463168
1276 1276 c, t dbSNP:773238245
1303 1303 a, g dbSNP:181042949
1309 1309 a, c dbSNP:122462166
1321 1321 c, t dbSNP:760583163
1337 1337 c, t dbSNP:148567981
1366 1366 a, g dbSNP:61735159
1370 1370 a, g dbSNP:151121012
1372 1372 c, t dbSNP:764876477
1374 1374 c, t dbSNP:752160420
1375 1375 a, g dbSNP:757814584
1378 1378 a, g dbSNP:778174682
1386 1386 a, c dbSNP:747483692
1390 1390 c, t dbSNP:757668001
1411 1411 c, t dbSNP:779221820
1417 1417 a, g, t dbSNP:10126585
1461 1461 c, t dbSNP:769915486
1465 1465 a, g dbSNP:775727430
1473 1473 c, t dbSNP:122462165
1483 1483 a, g dbSNP:749353346
1486 1486 a, c, g dbSNP:768745059
1498 1498 c, t dbSNP:760673255
1501 1501 c, t dbSNP:766341980
1507 1507 c, t dbSNP:759652207
1516 1516 a, g dbSNP:61735960
1531 1531 c, t dbSNP:759316036
1544 1544 a, g dbSNP:764818979
1568 1568 c, g dbSNP:763662353
1585 1585 c, t dbSNP:751075155
1614 1614 c, t dbSNP:761258496
1651 1651 c, t dbSNP:768036826
1660 1660 c, g dbSNP:750905477
1663 1663 a, g dbSNP:773879335
1676 1676 a, g dbSNP:756480202
1681 1681 a, g dbSNP:780449661
1684 1684 c, t dbSNP:754070677
1693 1693 c, g dbSNP:755253459
1699 1699 g, t dbSNP:143990850
1718 1718 a, g dbSNP:104894962
1727 1727 a, t dbSNP:387906498
1740 1740 c, t dbSNP:754241460
1753 1753 g, t dbSNP:755343529
1756 1756 c, t dbSNP:765585606
1767 1767 c, t dbSNP:752936376
1782 1782 a, t dbSNP:758600009
1796 1796 c, t dbSNP:765128011
1798 1798 a, c dbSNP:777895494
1828 1828 a, c dbSNP:745861579
1831 1831 a, t dbSNP:756083842
1835 1835 a, c dbSNP:779799532
1844 1844 a, g dbSNP:749105833
1847 1847 a, g, t dbSNP:375086818
1849 1849 a, c, t dbSNP:747781489
1850 1850 a, c dbSNP:772780189
1852 1852 a, t dbSNP:760042281
1853 1853 a, c dbSNP:766929373
1854 1854 c, t dbSNP:776962220
1855 1855 a, c, g, t dbSNP:760017218
1857 1857 c, g, t dbSNP:758689938
1859 1859 a, c dbSNP:199708513
1870 1870 c, t dbSNP:757238089
1875 1875 a, g dbSNP:780074821
1894 1894 -, at dbSNP:748030447
1895 1895 -, tatatattat dbSNP:772165853
1904 1904 c, g dbSNP:750385251
1905 1905 c, t dbSNP:28753954
1918 1918 a, g dbSNP:377035964
1919 1919 c, g dbSNP:754820282
1923 1923 c, t dbSNP:778670997
1935 1935 c, t dbSNP:370928726
1950 1950 a, g dbSNP:12387258
1951 1951 c, t dbSNP:367553369
1961 1961 a, g dbSNP:747521945
2055 2055 c, t dbSNP:758042725
2111 2111 a, g dbSNP:756910022
2169 2169 c, t dbSNP:41299098
2175 2175 c, t dbSNP:189945897
2309 2309 a, c dbSNP:745341731
2344 2344 c, t dbSNP:751049904
2398 2398 a, g dbSNP:183286584
2405 2405 c, g dbSNP:188158405
2458 2458 a, g dbSNP:746936081
2465 2465 c, t dbSNP:773353638
2486 2486 c, t dbSNP:192686023
2491 2491 a, g dbSNP:780846201
2493 2493 a, c dbSNP:768507518
2496 2496 -, t dbSNP:776380867
2545 2545 -, g dbSNP:35271758
2557 2557 a, t dbSNP:1053654
2624 2624 a, t dbSNP:749660087
2658 2658 -, aag dbSNP:759563150
2688 2688 -, act dbSNP:761993352
2692 2692 a, g dbSNP:182699220
2799 2799 a, g dbSNP:771292559
2908 2908 a, c dbSNP:187801928
2931 2931 a, g dbSNP:192578428
2958 2958 a, g dbSNP:779463899
3037 3037 g, t dbSNP:766549633
3048 3048 a, g dbSNP:752176102
3049 3049 g, t dbSNP:184391484
3098 3098 a, g dbSNP:41300285
3114 3114 g, t dbSNP:567389652
3127 3127 -, tctgt dbSNP:771433400
3146 3146 a, g, t dbSNP:772508899
3218 3218 c, t dbSNP:754848855
3220 3220 c, t dbSNP:189095612
3238 3238 a, t dbSNP:193001606
3271 3271 g, t dbSNP:775549541
3332 3332 c, t dbSNP:749914642
3383 3383 c, t dbSNP:757962223
3385 3385 a, g dbSNP:112250638
3402 3402 g, t dbSNP:779535842
3404 3404 a, g dbSNP:746990583
3411 3411 a, g dbSNP:768560560
3449 3449 a, g dbSNP:184855783
3530 3530 a, g dbSNP:747938910
3555 3555 c, t dbSNP:141562009
3567 3567 c, t dbSNP:773536203
3586 3586 c, t dbSNP:536230068
3619 3619 a, c dbSNP:763259751
3704 3704 c, g dbSNP:747064566
3718 3718 g, t dbSNP:771172525
3740 3740 a, g dbSNP:189739012
3799 3799 a, c dbSNP:760141437
3866 3866 g, t dbSNP:76159565
3887 3887 a, t dbSNP:768096443
3933 3933 c, g dbSNP:113057036

Target ORF information:

RefSeq Version NM_003413
Organism Homo sapiens (human)
Definition Homo sapiens Zic family member 3 (ZIC3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003413

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGACGATGC TCCTGGACGG AGGCCCGCAG TTCCCTGGGC TGGGAGTGGG CAGCTTCGGC 
GCGCCGCGCC ACCACGAGAT GCCCAACCGT GAGCCGGCAG GCATGGGGCT GAATCCCTTC
GGGGACTCAA CCCACGCCGC CGCCGCCGCC GCCGCCGCCG CTGCCTTCAA GCTGAGCCCT
GCCGCGGCGC ACGATCTATC TTCAGGCCAG AGCTCGGCTT TCACGCCGCA GGGTTCGGGC
TACGCCAACG CCCTGGGCCA CCATCACCAC CACCATCACC ATCATCACCA CACCAGCCAG
GTGCCCAGCT ACGGTGGCGC TGCCTCTGCC GCCTTCAACT CAACGCGCGA GTTTCTGTTC
CGCCAGCGCA GCTCCGGGCT CAGTGAGGCG GCCTCGGGTG GCGGGCAGCA CGGGCTCTTC
GCCGGCTCGG CGAGCAGCCT GCATGCTCCA GCTGGCATCC CCGAGCCCCC TAGCTACTTG
CTGTTTCCCG GGCTGCATGA GCAGGGCGCT GGGCACCCGT CGCCCACAGG GCACGTGGAC
AACAACCAGG TCCACCTGGG GCTGCGTGGG GAGCTGTTCG GCCGTGCTGA CCCATACCGC
CCAGTGGCCA GCCCGCGCAC GGACCCCTAC GCGGCCGGCG CTCAGTTTCC TAACTACAGC
CCCATGAACA TGAACATGGG AGTGAACGTG GCGGCCCACC ACGGGCCCGG CGCCTTCTTC
CGTTATATGC GGCAGCCTAT CAAGCAGGAG CTGTCGTGCA AGTGGATCGA CGAGGCTCAG
CTGAGCCGGC CCAAGAAGAG CTGCGACCGG ACCTTCAGCA CCATGCATGA GCTGGTGACA
CATGTCACCA TGGAGCATGT GGGGGGCCCG GAGCAGAACA ACCACGTCTG CTACTGGGAG
GAGTGCCCCC GGGAGGGCAA GTCTTTCAAG GCGAAGTACA AACTGGTCAA CCACATCCGA
GTGCACACGG GCGAGAAGCC CTTCCCATGC CCCTTCCCGG GCTGCGGGAA GATCTTTGCC
CGTTCTGAGA ACCTCAAGAT CCACAAGAGG ACCCACACAG GTGAGAAACC TTTCAAATGT
GAATTTGAAG GCTGTGACAG ACGCTTTGCC AACAGCAGCG ACCGTAAGAA GCACATGCAT
GTGCATACCT CGGACAAGCC CTATATCTGC AAAGTGTGCG ACAAGTCCTA CACGCACCCG
AGCTCCCTGC GCAAACACAT GAAGGTTCAT GAATCTCAAG GGTCAGATTC CTCCCCTGCT
GCCAGTTCAG GCTATGAATC TTCCACTCCA CCCGCTATAG CTTCTGCAAA CAGTAAAGAT
ACCACTAAAA CCCCTTCTGC AGTTCAAACT AGCACCAGCC ACAACCCTGG ACTTCCTCCT
AATTTTAACG AATGGTACGT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.