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RAB7A cDNA ORF clone, Homo sapiens (human)

Gene Symbol RAB7A
Entrez Gene ID 7879
Full Name RAB7A, member RAS oncogene family
Synonyms PRO2706, RAB7
General protein information
Preferred Names
ras-related protein Rab-7a
Names
ras-related protein Rab-7a
Ras-associated protein RAB7
RAB7, member RAS oncogene family
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q21.3

Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602298

Disorder Html: Charcot-Marie-Tooth disease, type 2B, 600882 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_004637 NP_004628 ras-related protein Rab-7a



Homo sapiens (human) RAB7A NP_004628.4
Pan troglodytes (chimpanzee) RAB7A XP_003950230.1
Macaca mulatta (Rhesus monkey) RAB7A XP_001095709.2
Canis lupus familiaris (dog) RAB7A NP_001003316.1
Bos taurus (cattle) RAB7A NP_001030253.1
Mus musculus (house mouse) Rab7 NP_033031.2
Rattus norvegicus (Norway rat) Rab7a NP_076440.1
Gallus gallus (chicken) RAB7A XP_003642026.1
Danio rerio (zebrafish) rab7 NP_957222.1
Arabidopsis thaliana (thale cress) RAB7B NP_188512.1
Arabidopsis thaliana (thale cress) RABG3E NP_001031161.1
Xenopus (Silurana) tropicalis (western clawed frog) rab7a NP_001008026.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following RAB7A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB7A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25792
NM_004637 Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25792
Clone ID Related Accession (Same CDS sequence) NM_004637
Accession Version NM_004637.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 624bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ras-related protein Rab-7a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU122058.1, AF498942.1, BC008721.2, AK094449.1 and CA748697.1. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2004 this sequence version replaced gi:34147512. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008721.2, BM910436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGACCTCTA GGAAGAAAGT GTTGCTGAAG GTTATCATCC TGGGAGATTC TGGAGTCGGG 
AAGACATCAC TCATGAACCA GTATGTGAAT AAGAAATTCA GCAATCAGTA CAAAGCCACA
ATAGGAGCTG ACTTTCTGAC CAAGGAGGTG ATGGTGGATG ACAGGCTAGT CACAATGCAG
ATATGGGACA CAGCAGGACA GGAACGGTTC CAGTCTCTCG GTGTGGCCTT CTACAGAGGT
GCAGACTGCT GCGTTCTGGT ATTTGATGTG ACTGCCCCCA ACACATTCAA AACCCTAGAT
AGCTGGAGAG ATGAGTTTCT CATCCAGGCC AGTCCCCGAG ATCCTGAAAA CTTCCCATTT
GTTGTGTTGG GAAACAAGAT TGACCTCGAA AACAGACAAG TGGCCACAAA GCGGGCACAG
GCCTGGTGCT ACAGCAAAAA CAACATTCCC TACTTTGAGA CCAGTGCCAA GGAGGCCATC
AACGTGGAGC AGGCGTTCCA GACGATTGCA CGGAATGCAC TTAAGCAGGA AACGGAGGTG
GAGCTGTACA ACGAATTTCC TGAACCTATC AAACTGGACA AGAATGACCG GGCCAAGGCC
TCGGCAGAAA GCTGCAGTTG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004628.4
CDS233..856
Misc Feature(1)227..229(+)
Misc Feature(2)257..769(+)
Misc Feature(3)257..262(+)
Misc Feature(4)260..757(+)
Misc Feature(5)275..298(+)
Misc Feature(6)281..703(+)
Misc Feature(7)281..469(+)
Misc Feature(8)299..349(+)
Misc Feature(9)329..370(+)
Misc Feature(10)341..367(+)
Misc Feature(11)344..406(+)
Misc Feature(12)350..352(+)
Misc Feature(13)353..751(+)
Misc Feature(14)353..367(+)
Misc Feature(15)404..418(+)
Misc Feature(16)419..430(+)
Misc Feature(17)428..466(+)
Misc Feature(18)437..454(+)
Misc Feature(19)446..448(+)
Misc Feature(20)461..475(+)
Misc Feature(21)488..505(+)
Misc Feature(22)581..598(+)
Misc Feature(23)605..616(+)
Misc Feature(24)695..703(+)
Misc Feature(25)743..769(+)
Misc Feature(26)779..781(+)
Misc Feature(27)845..847(+)
Misc Feature(28)851..853(+)
Exon (1)1..224
Gene:RAB7A
Gene Synonym:
Exon (2)225..285
Gene:RAB7A
Gene Synonym:
Exon (3)286..412
Gene:RAB7A
Gene Synonym:
Exon (4)413..631
Gene:RAB7A
Gene Synonym:
Exon (5)632..760
Gene:RAB7A
Gene Synonym:
Exon (6)761..2232
Gene:RAB7A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004637
Organism Homo sapiens (human)
Definition Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004637

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCTCTA GGAAGAAAGT GTTGCTGAAG GTTATCATCC TGGGAGATTC TGGAGTCGGG 
AAGACATCAC TCATGAACCA GTATGTGAAT AAGAAATTCA GCAATCAGTA CAAAGCCACA
ATAGGAGCTG ACTTTCTGAC CAAGGAGGTG ATGGTGGATG ACAGGCTAGT CACAATGCAG
ATATGGGACA CAGCAGGACA GGAACGGTTC CAGTCTCTCG GTGTGGCCTT CTACAGAGGT
GCAGACTGCT GCGTTCTGGT ATTTGATGTG ACTGCCCCCA ACACATTCAA AACCCTAGAT
AGCTGGAGAG ATGAGTTTCT CATCCAGGCC AGTCCCCGAG ATCCTGAAAA CTTCCCATTT
GTTGTGTTGG GAAACAAGAT TGACCTCGAA AACAGACAAG TGGCCACAAA GCGGGCACAG
GCCTGGTGCT ACAGCAAAAA CAACATTCCC TACTTTGAGA CCAGTGCCAA GGAGGCCATC
AACGTGGAGC AGGCGTTCCA GACGATTGCA CGGAATGCAC TTAAGCAGGA AACGGAGGTG
GAGCTGTACA ACGAATTTCC TGAACCTATC AAACTGGACA AGAATGACCG GGCCAAGGCC
TCGGCAGAAA GCTGCAGTTG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A novel RAB7 mutation in a Chinese family with Charcot-Marie-Tooth type 2B disease
Gene 534 (2), 431-434 (2014)
Wang,X., Han,C., Liu,W., Wang,P. and Zhang,X.


book

Rab family proteins regulate the endosomal trafficking and function of RGS4
J. Biol. Chem. 288 (30), 21836-21849 (2013)
Bastin G and Heximer SP.


book

Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment
J. Virol. 87 (11), 6415-6427 (2013)
Macovei A, Petrareanu C, Lazar C, Florian P and Branza-Nichita N.


book

The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy
Dev. Cell 25 (1), 15-28 (2013)
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I and Braga VM.


book

Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid
Biochem. Biophys. Res. Commun. 229 (3), 887-890 (1996)
Vitelli R, Chiariello M, Lattero D, Bruni CB and Bucci C.


book

Rab4 and Rab7 define distinct nonoverlapping endosomal compartments
J. Biol. Chem. 271 (46), 29191-29197 (1996)
Bottger G, Nagelkerken B and van der Sluijs P.


book

Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions
J. Biol. Chem. 271 (34), 20470-20478 (1996)
Simon I, Zerial M and Goody RS.


book

Charcot-Marie-Tooth Hereditary Neuropathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bird,T.D.


book

Charcot-Marie-Tooth Neuropathy Type 2
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bird,T.D.


book

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
Cell 62 (2), 317-329 (1990)
Chavrier P, Parton RG, Hauri HP, Simons K and Zerial M.


 
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