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RAB7A RAB7A, member RAS oncogene family [Homo sapiens (human)]

Gene Symbol RAB7A
Entrez Gene ID 7879
Full Name RAB7A, member RAS oncogene family
Synonyms PRO2706, RAB7
General protein information
Preferred Names
ras-related protein Rab-7a
Names
ras-related protein Rab-7a
Ras-associated protein RAB7
RAB7, member RAS oncogene family
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q21.3

Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602298

Disorder Html: Charcot-Marie-Tooth disease, type 2B, 600882 (3)





The following RAB7A gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAB7A gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25792 NM_004637 Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu25792
Accession Version NM_004637.5
Sequence Information ORF Nucleotide Sequence (Length: 624bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product ras-related protein Rab-7a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU122058.1, AF498942.1, BC008721.2, AK094449.1 and CA748697.1. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2004 this sequence version replaced gi:34147512. Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC008721.2, BM910436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGACCTCTA GGAAGAAAGT GTTGCTGAAG GTTATCATCC TGGGAGATTC TGGAGTCGGG 
AAGACATCAC TCATGAACCA GTATGTGAAT AAGAAATTCA GCAATCAGTA CAAAGCCACA
ATAGGAGCTG ACTTTCTGAC CAAGGAGGTG ATGGTGGATG ACAGGCTAGT CACAATGCAG
ATATGGGACA CAGCAGGACA GGAACGGTTC CAGTCTCTCG GTGTGGCCTT CTACAGAGGT
GCAGACTGCT GCGTTCTGGT ATTTGATGTG ACTGCCCCCA ACACATTCAA AACCCTAGAT
AGCTGGAGAG ATGAGTTTCT CATCCAGGCC AGTCCCCGAG ATCCTGAAAA CTTCCCATTT
GTTGTGTTGG GAAACAAGAT TGACCTCGAA AACAGACAAG TGGCCACAAA GCGGGCACAG
GCCTGGTGCT ACAGCAAAAA CAACATTCCC TACTTTGAGA CCAGTGCCAA GGAGGCCATC
AACGTGGAGC AGGCGTTCCA GACGATTGCA CGGAATGCAC TTAAGCAGGA AACGGAGGTG
GAGCTGTACA ACGAATTTCC TGAACCTATC AAACTGGACA AGAATGACCG GGCCAAGGCC
TCGGCAGAAA GCTGCAGTTG CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_004628.4
CDS233..856
Misc Feature(1)227..229(+)
Misc Feature(2)257..769(+)
Misc Feature(3)257..262(+)
Misc Feature(4)260..757(+)
Misc Feature(5)275..298(+)
Misc Feature(6)281..703(+)
Misc Feature(7)281..469(+)
Misc Feature(8)299..349(+)
Misc Feature(9)329..370(+)
Misc Feature(10)341..367(+)
Misc Feature(11)344..406(+)
Misc Feature(12)350..352(+)
Misc Feature(13)353..751(+)
Misc Feature(14)353..367(+)
Misc Feature(15)404..418(+)
Misc Feature(16)419..430(+)
Misc Feature(17)428..466(+)
Misc Feature(18)437..454(+)
Misc Feature(19)446..448(+)
Misc Feature(20)461..475(+)
Misc Feature(21)488..505(+)
Misc Feature(22)581..598(+)
Misc Feature(23)605..616(+)
Misc Feature(24)695..703(+)
Misc Feature(25)743..769(+)
Misc Feature(26)779..781(+)
Misc Feature(27)845..847(+)
Misc Feature(28)851..853(+)
Exon (1)1..224
Gene:RAB7A
Gene Synonym:
Exon (2)225..285
Gene:RAB7A
Gene Synonym:
Exon (3)286..412
Gene:RAB7A
Gene Synonym:
Exon (4)413..631
Gene:RAB7A
Gene Synonym:
Exon (5)632..760
Gene:RAB7A
Gene Synonym:
Exon (6)761..2232
Gene:RAB7A
Gene Synonym:
Translation
Position Chain Variation Link
18 18 -, ggcggt dbSNP:770559386
18 18 c, t dbSNP:560785742
35 35 c, g dbSNP:766601787
58 58 a, t dbSNP:774064602
99 99 g, t dbSNP:112026138
100 100 a, c dbSNP:555863800
118 118 c, t dbSNP:374777610
136 136 c, g dbSNP:141622970
163 163 -, ctc dbSNP:763539443
165 165 c, t dbSNP:567590545
196 196 a, g dbSNP:531862365
204 204 g, t dbSNP:112000804
206 206 c, t dbSNP:571542071
214 214 c, t dbSNP:772486152
224 224 g, t dbSNP:11549760
227 227 c, t dbSNP:777086793
252 252 a, t dbSNP:11549752
253 253 a, g dbSNP:140857794
259 259 a, g dbSNP:756651096
263 263 c, g dbSNP:150089960
266 266 a, g dbSNP:780732950
289 289 c, t dbSNP:373510884
319 319 a, g dbSNP:145441548
321 321 a, g dbSNP:201407628
326 326 a, g dbSNP:11549759
336 336 a, g dbSNP:747270770
340 340 a, g dbSNP:529173052
347 347 a, g dbSNP:776746396
352 352 a, c dbSNP:745731016
384 384 c, t dbSNP:769771992
399 399 c, t dbSNP:775104487
410 410 c, t dbSNP:11549755
413 413 a, g dbSNP:749968204
415 415 a, c dbSNP:376642691
422 422 a, g dbSNP:747759228
434 434 a, g dbSNP:11549758
445 445 a, g dbSNP:140299645
451 451 c, t dbSNP:4548
460 460 c, t dbSNP:11549757
463 463 c, t dbSNP:758757916
484 484 c, t dbSNP:778176566
485 485 a, g dbSNP:747215257
487 487 g, t dbSNP:757479568
509 509 c, g, t dbSNP:11549756
520 520 c, g dbSNP:745988626
529 529 a, g dbSNP:543782151
532 532 c, t dbSNP:138982701
553 553 c, t dbSNP:749227632
562 562 c, t dbSNP:556570036
568 568 a, c dbSNP:768572013
570 570 a, g dbSNP:142136407
586 586 c, t dbSNP:774346438
601 601 a, g dbSNP:761501241
617 617 c, t dbSNP:121909078
619 619 c, t dbSNP:767284504
635 635 a, g dbSNP:368804888
637 637 c, t dbSNP:753869029
646 646 g, t dbSNP:754928233
653 653 a, g, t dbSNP:201399896
655 655 c, g dbSNP:61758751
661 661 c, t dbSNP:777486903
667 667 c, t dbSNP:746610394
693 693 c, g dbSNP:770494797
703 703 c, g dbSNP:121909081
714 714 a, c dbSNP:121909080
716 716 a, g dbSNP:121909079
721 721 c, g dbSNP:200290674
726 726 c, t dbSNP:776165312
727 727 a, g dbSNP:146566121
735 735 c, t dbSNP:141978327
737 737 a, g dbSNP:774810842
738 738 c, t dbSNP:375630134
739 739 c, t dbSNP:767911042
740 740 a, g dbSNP:750766845
743 743 a, c dbSNP:1802891
748 748 a, t dbSNP:760888311
765 765 c, t dbSNP:142747565
766 766 a, g dbSNP:766818777
770 770 a, g dbSNP:186247059
776 776 a, c dbSNP:140685176
781 781 c, t dbSNP:192418864
783 783 a, g dbSNP:752824265
784 784 c, g, t dbSNP:143140848
800 800 a, g dbSNP:147480945
809 809 a, g dbSNP:756968558
813 813 a, c dbSNP:781110052
821 821 c, g, t dbSNP:745507763
822 822 a, g dbSNP:779472408
824 824 a, g dbSNP:748832566
835 835 a, g dbSNP:61748098
844 844 c, t dbSNP:773572403
853 853 c, t dbSNP:747616052
861 861 a, c, g dbSNP:771183870
876 876 -, ca dbSNP:761702262
878 878 c, g dbSNP:759761853
879 879 a, g dbSNP:765587347
881 881 a, g dbSNP:775661322
885 885 c, t dbSNP:762917615
890 890 a, c dbSNP:764272943
891 891 a, c dbSNP:751449841
899 899 a, g dbSNP:199811322
904 904 a, g dbSNP:767242981
905 905 c, t dbSNP:373308557
906 906 a, g dbSNP:755728008
929 929 -, ctc dbSNP:750509935
939 939 c, t dbSNP:376932040
941 941 a, g dbSNP:549333234
1015 1015 -, tctc dbSNP:756987557
1019 1019 -, ca dbSNP:3830294
1019 1019 g, t dbSNP:182521602
1022 1022 -, cacacacacacacacg dbSNP:541418692
1024 1024 -, cacacacacacacg dbSNP:146444984
1037 1037 a, g dbSNP:3206306
1038 1038 -, ca dbSNP:139417205
1039 1039 a, g dbSNP:774054837
1045 1045 a, g dbSNP:11549750
1057 1057 c, t dbSNP:138714412
1061 1061 c, t dbSNP:757348735
1062 1062 a, g dbSNP:16851333
1082 1082 g, t dbSNP:571355772
1085 1085 c, t dbSNP:147244704
1086 1086 c, g dbSNP:751015573
1088 1088 c, g dbSNP:561760979
1120 1120 a, c dbSNP:114778883
1130 1130 a, g dbSNP:565849348
1154 1154 c, t dbSNP:536720093
1171 1171 a, g dbSNP:555274287
1212 1212 -, ga dbSNP:201899446
1223 1223 a, g dbSNP:575228150
1227 1227 -, t dbSNP:747970461
1229 1229 g, t dbSNP:567411812
1261 1261 c, t dbSNP:537789867
1266 1266 a, t dbSNP:11549751
1306 1306 a, c dbSNP:556493561
1401 1401 c, t dbSNP:754668337
1427 1427 a, t dbSNP:10222
1444 1444 a, c dbSNP:544316328
1455 1455 a, g dbSNP:577741634
1481 1481 c, t dbSNP:545004919
1483 1483 c, g dbSNP:570589054
1530 1530 a, g dbSNP:1065349
1614 1614 a, c dbSNP:769239958
1616 1616 c, t dbSNP:564093776
1625 1625 a, g dbSNP:115008416
1642 1642 a, g dbSNP:561364216
1655 1655 a, g dbSNP:531931208
1675 1675 a, c dbSNP:772662283
1676 1676 a, g dbSNP:369256306
1692 1692 c, t dbSNP:565225588
1696 1696 a, g dbSNP:757917555
1698 1698 a, g dbSNP:749258878
1702 1702 a, g dbSNP:532629721
1706 1706 g, t dbSNP:547405796
1719 1719 c, g dbSNP:59753334
1764 1764 a, c, g dbSNP:546868558
1846 1846 -, t dbSNP:371200521
1853 1853 c, g, t dbSNP:3755593
1860 1860 -, t dbSNP:777387248
1864 1864 c, g dbSNP:560464472
1877 1877 c, t dbSNP:373116095
1882 1882 a, g dbSNP:376185459
1885 1885 a, g dbSNP:776759455
1904 1904 a, g dbSNP:762072514
1935 1935 c, t dbSNP:141066124
1956 1956 a, t dbSNP:556530753
1997 1997 c, t dbSNP:192329045
1998 1998 a, g dbSNP:747470481
2022 2022 c, t dbSNP:529245514
2033 2033 a, g, t dbSNP:144914469
2042 2042 a, t dbSNP:755328753
2054 2054 c, g dbSNP:765427178
2057 2057 c, t dbSNP:553813614
2104 2104 a, g dbSNP:571998983
2108 2108 -, c dbSNP:34564209
2110 2110 a, g dbSNP:377543858
2129 2129 a, g dbSNP:750489618
2141 2141 -, c dbSNP:34629369
2142 2142 g, t dbSNP:542407020
2157 2157 a, g dbSNP:182528613
2162 2162 c, t dbSNP:1050006
2191 2191 a, g dbSNP:1050012
2199 2199 c, t dbSNP:576597041
2200 2200 g, t dbSNP:763557372
2203 2203 a, g dbSNP:543627663
2215 2215 c, t dbSNP:147938224
2230 2230 a, g dbSNP:539522952

Target ORF information:

RefSeq Version NM_004637
Organism Homo sapiens (human)
Definition Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004637

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCTCTA GGAAGAAAGT GTTGCTGAAG GTTATCATCC TGGGAGATTC TGGAGTCGGG 
AAGACATCAC TCATGAACCA GTATGTGAAT AAGAAATTCA GCAATCAGTA CAAAGCCACA
ATAGGAGCTG ACTTTCTGAC CAAGGAGGTG ATGGTGGATG ACAGGCTAGT CACAATGCAG
ATATGGGACA CAGCAGGACA GGAACGGTTC CAGTCTCTCG GTGTGGCCTT CTACAGAGGT
GCAGACTGCT GCGTTCTGGT ATTTGATGTG ACTGCCCCCA ACACATTCAA AACCCTAGAT
AGCTGGAGAG ATGAGTTTCT CATCCAGGCC AGTCCCCGAG ATCCTGAAAA CTTCCCATTT
GTTGTGTTGG GAAACAAGAT TGACCTCGAA AACAGACAAG TGGCCACAAA GCGGGCACAG
GCCTGGTGCT ACAGCAAAAA CAACATTCCC TACTTTGAGA CCAGTGCCAA GGAGGCCATC
AACGTGGAGC AGGCGTTCCA GACGATTGCA CGGAATGCAC TTAAGCAGGA AACGGAGGTG
GAGCTGTACA ACGAATTTCC TGAACCTATC AAACTGGACA AGAATGACCG GGCCAAGGCC
TCGGCAGAAA GCTGCAGTTG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.