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TMEM43 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TMEM43
Entrez Gene ID 79188
Full Name transmembrane protein 43
Synonyms ARVC5, ARVD5, EDMD7, LUMA
General protein information
Preferred Names
transmembrane protein 43
Names
transmembrane protein 43
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p25.1

Summary This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

612048

Disorder Html: Arrhythmogenic right ventricular dysplasia, familial, 5, 604400 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011534109 XP_011532411 transmembrane protein 43 isoform X1
NM_024334 NP_077310 transmembrane protein 43


Homo sapiens (human) TMEM43 NP_077310.1
Pan troglodytes (chimpanzee) TMEM43 XP_001157301.1
Macaca mulatta (Rhesus monkey) TMEM43 XP_001091243.1
Canis lupus familiaris (dog) TMEM43 XP_541751.2
Bos taurus (cattle) TMEM43 NP_001095950.1
Mus musculus (house mouse) Tmem43 NP_083042.1
Rattus norvegicus (Norway rat) Tmem43 NP_001007746.1
Gallus gallus (chicken) TMEM43 XP_414378.1
Danio rerio (zebrafish) tmem43 NP_998403.1
Drosophila melanogaster (fruit fly) CG8111 NP_648162.2
Xenopus (Silurana) tropicalis (western clawed frog) tmem43 XP_002938277.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TMEM43 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM43 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu71826 XM_011534109 PREDICTED: Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu19231
NM_024334 Homo sapiens transmembrane protein 43 (TMEM43), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu71826
Clone ID Related Accession (Same CDS sequence) XM_011534109
Accession Version XM_011534109.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1098bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 43 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_022517.19) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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721
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841
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961
1021
1081
ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011532411.1
CDS1951..3048
Misc Feature(1)2206..2964(+)
Translation

Target ORF information:

RefSeq Version XM_011534109
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens transmembrane protein 43 (TMEM43), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011534109

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTTTGTGG GGCTCATGGC CTTCCTGCTC TCCTTCTACC TAATTTTCAC CAATGAGGGC 
CGCGCATTGA AGACGGCAAC CTCATTGGCT GAGGGGCTCT CGCTTGTGGT GTCTCCCGAC
AGCATCCACA GTGTGGCTCC GGAGAATGAA GGAAGGCTGG TGCACATCAT TGGCGCCTTA
CGGACATCCA AGCTTTTGTC TGATCCAAAC TATGGGGTCC ATCTTCCGGC TGTGAAACTG
CGGAGGCACG TGGAGATGTA CCAATGGGTA GAAACTGAGG AGTCCAGGGA GTACACCGAG
GATGGGCAGG TGAAGAAGGA GACGAGGTAT TCCTACAACA CTGAATGGAG GTCAGAAATC
ATCAACAGCA AAAACTTCGA CCGAGAGATT GGCCACAAAA ACCCCAGTGC CATGGCAGTG
GAGTCATTCA TGGCAACAGC CCCCTTTGTC CAAATTGGCA GGTTTTTCCT CTCGTCAGGC
CTCATCGACA AAGTCGACAA CTTCAAGTCC CTGAGCCTAT CCAAGCTGGA GGACCCTCAT
GTGGACATCA TTCGCCGTGG AGACTTTTTC TACCACAGCG AAAATCCCAA GTATCCAGAG
GTGGGAGACT TGCGTGTCTC CTTTTCCTAT GCTGGACTGA GCGGCGATGA CCCTGACCTG
GGCCCAGCTC ACGTGGTCAC TGTGATTGCC CGGCAGCGGG GTGACCAGCT AGTCCCATTC
TCCACCAAGT CTGGGGATAC CTTACTGCTC CTGCACCACG GGGACTTCTC AGCAGAGGAG
GTGTTTCATA GAGAACTAAG GAGCAACTCC ATGAAGACCT GGGGCCTGCG GGCAGCTGGC
TGGATGGCCA TGTTCATGGG CCTCAACCTT ATGACACGGA TCCTCTACAC CTTGGTGGAC
TGGTTTCCTG TTTTCCGAGA CCTGGTCAAC ATTGGCCTGA AAGCCTTTGC CTTCTGTGTG
GCCACCTCGC TGACCCTGCT GACCGTGGCG GCTGGCTGGC TCTTCTACCG ACCCCTGTGG
GCCCTCCTCA TTGCCGGCCT GGCCCTTGTG CCCATCCTTG TTGCTCGGAC ACGGGTGCCA
GCCAAAAAGT TGGAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19231
Clone ID Related Accession (Same CDS sequence) NM_024334
Accession Version NM_024334.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1203bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 43
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA259919.1, BC003125.1 and AY358625.1. This sequence is a reference standard in the RefSeqGene project. On Sep 13, 2008 this sequence version replaced gi:13236586. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003125.1, AL136916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_077310.1
CDS255..1457
Misc Feature(1)216..218(+)
Misc Feature(2)258..260(+)
Misc Feature(3)348..410(+)
Misc Feature(4)615..1373(+)
Misc Feature(5)1194..1256(+)
Misc Feature(6)1290..1352(+)
Misc Feature(7)1359..1421(+)
Exon (1)1..266
Gene:TMEM43
Gene Synonym:
Exon (2)267..416
Gene:TMEM43
Gene Synonym:
Exon (3)417..551
Gene:TMEM43
Gene Synonym:
Exon (4)552..646
Gene:TMEM43
Gene Synonym:
Exon (5)647..696
Gene:TMEM43
Gene Synonym:
Exon (6)697..766
Gene:TMEM43
Gene Synonym:
Exon (7)767..837
Gene:TMEM43
Gene Synonym:
Exon (8)838..959
Gene:TMEM43
Gene Synonym:
Exon (9)960..1034
Gene:TMEM43
Gene Synonym:
Exon (10)1035..1136
Gene:TMEM43
Gene Synonym:
Exon (11)1137..1254
Gene:TMEM43
Gene Synonym:
Exon (12)1255..3342
Gene:TMEM43
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_024334
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protein 43 (TMEM43), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024334

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCCGCGA ATTATTCCAG TACCAGTACC CGGAGAGAAC ATGTCAAAGT TAAAACCAGC 
TCCCAGCCAG GCTTCCTGGA ACGGCTGAGC GAGACCTCGG GTGGGATGTT TGTGGGGCTC
ATGGCCTTCC TGCTCTCCTT CTACCTAATT TTCACCAATG AGGGCCGCGC ATTGAAGACG
GCAACCTCAT TGGCTGAGGG GCTCTCGCTT GTGGTGTCTC CCGACAGCAT CCACAGTGTG
GCTCCGGAGA ATGAAGGAAG GCTGGTGCAC ATCATTGGCG CCTTACGGAC ATCCAAGCTT
TTGTCTGATC CAAACTATGG GGTCCATCTT CCGGCTGTGA AACTGCGGAG GCACGTGGAG
ATGTACCAAT GGGTAGAAAC TGAGGAGTCC AGGGAGTACA CCGAGGATGG GCAGGTGAAG
AAGGAGACGA GGTATTCCTA CAACACTGAA TGGAGGTCAG AAATCATCAA CAGCAAAAAC
TTCGACCGAG AGATTGGCCA CAAAAACCCC AGTGCCATGG CAGTGGAGTC ATTCATGGCA
ACAGCCCCCT TTGTCCAAAT TGGCAGGTTT TTCCTCTCGT CAGGCCTCAT CGACAAAGTC
GACAACTTCA AGTCCCTGAG CCTATCCAAG CTGGAGGACC CTCATGTGGA CATCATTCGC
CGTGGAGACT TTTTCTACCA CAGCGAAAAT CCCAAGTATC CAGAGGTGGG AGACTTGCGT
GTCTCCTTTT CCTATGCTGG ACTGAGCGGC GATGACCCTG ACCTGGGCCC AGCTCACGTG
GTCACTGTGA TTGCCCGGCA GCGGGGTGAC CAGCTAGTCC CATTCTCCAC CAAGTCTGGG
GATACCTTAC TGCTCCTGCA CCACGGGGAC TTCTCAGCAG AGGAGGTGTT TCATAGAGAA
CTAAGGAGCA ACTCCATGAA GACCTGGGGC CTGCGGGCAG CTGGCTGGAT GGCCATGTTC
ATGGGCCTCA ACCTTATGAC ACGGATCCTC TACACCTTGG TGGACTGGTT TCCTGTTTTC
CGAGACCTGG TCAACATTGG CCTGAAAGCC TTTGCCTTCT GTGTGGCCAC CTCGCTGACC
CTGCTGACCG TGGCGGCTGG CTGGCTCTTC TACCGACCCC TGTGGGCCCT CCTCATTGCC
GGCCTGGCCC TTGTGCCCAT CCTTGTTGCT CGGACACGGG TGCCAGCCAA AAAGTTGGAG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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