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HPS6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol HPS6
Entrez Gene ID 79803
Full Name Hermansky-Pudlak syndrome 6
General protein information
Preferred Names
Hermansky-Pudlak syndrome 6 protein
Names
Hermansky-Pudlak syndrome 6 protein
ruby-eye protein homolog
Hermansky-Pudlak syndrome-6 protein (HPS6)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q24.32

Summary This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 5 protein. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 6. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607522

Disorder Html: Hermansky-Pudlak syndrome 6, 203300 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_024747 NP_079023 Hermansky-Pudlak syndrome 6 protein


Homo sapiens (human) HPS6 NP_079023.2
Pan troglodytes (chimpanzee) HPS6 XP_001170704.1
Macaca mulatta (Rhesus monkey) HPS6 XP_001111761.1
Canis lupus familiaris (dog) HPS6 XP_851823.2
Bos taurus (cattle) HPS6 NP_001075055.1
Mus musculus (house mouse) Hps6 NP_789742.2
Rattus norvegicus (Norway rat) Hps6 NP_852097.1
Gallus gallus (chicken) HPS6 XP_001233664.1
Danio rerio (zebrafish) LOC101882947 XP_005156992.1
Xenopus (Silurana) tropicalis (western clawed frog) hps6 XP_002940614.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HPS6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HPS6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19197
NM_024747 Homo sapiens Hermansky-Pudlak syndrome 6 (HPS6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$279.50-$391.30
$559.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19197
Clone ID Related Accession (Same CDS sequence) NM_024747
Accession Version NM_024747.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2328bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product Hermansky-Pudlak syndrome 6 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI761726.1, BC011594.1 and BC080564.1. This sequence is a reference standard in the RefSeqGene project. On Feb 5, 2011 this sequence version replaced gi:31881784. ##Evidence-Data-START## Transcript is intronless :: BC014993.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGAAGCGCT CGGGGACTCT GCGGCTGCTC TCGGACCTGA GCGCCTTCGG CGGCGCGGCG 
CGGCTCCGGG AGCTGGTGGC CGGGGACTCA GCGGTCCGAG TCCGTGGCAG TCCGGACGGC
CGCCACTTGC TGCTCCTGCG ACCCCCTGGG GCGGTAGCCC CACAGCTGCT AGTCGCGTCG
CGAGGGCCCG GCGCGGAGCT AGAGCGGGCC TGGCCGGCCG GCCAGCCCTC CCCGCTGGAC
GCCTTCTTCC TGCCGTGGCC AGCGCGGCCG GCGCTGGTGC TGGTGTGGGA GAGTGGCCTG
GCCGAGGTGT GGGGCGCGGG CGTGGGGCCT GGCTGGCGGC CGCTGCAGAG CACCGAGCTG
TGTCCGGGCG GGGGAGCCCG CGTTGTGGCA GTGGCGGCGC TCCGAGGCCG CCTGGTGTGG
TGCGAGGAGC GGCAGGCCCG GGCCGAGGGC CCGTCAGGGT CGCCAGCAGC CGCTTTCAGC
CACTGTGTGT GCGTCCGGAC TCTGGAGCCC AGCGGGGAAG CTAGCACCAG CCTGGGCCGC
ACACACGTCC TGCTGCACCA CTGCCCTGCC TTCGGGCTGC TGGCCTCCTG CAGACAACTC
TTCCTGGTGC CCACTGCCAC CACCTGGCCT GGCGTGGCCC ACGTTCTACT CATCTGGAGC
CCAGGCAAGG GCAAAGTGAT GGTGGCTGCC CCACGGCTTG GTCTCTCCTA CAGTAAGAGT
CTGAATCCTG GACGAGGGGA CACATGGGAC TTCCGGACCC TGCTCCGAGG CCTTCCTGGG
TTGCTGTCCC CCAGGGAGCC ACTGGCTGTA CACACCTGGG CCCCAACTCC CCAGGGCCTG
CTGTTGCTTG ACTTCGGGGG CACTGTGAGC CTATTGCAGT CCCACGGTGG TACGCGGGCT
GTGGGCACCC TGCAGGAGGC ACCTGTAGGC CCGTGGGGGT CTGCAGCCCT AGGCACATTT
CAGGGCACTC TGGCCTGTGT GCTGGGCTCC ACATTGGAAC TGCTGGACAT GGGCAGTGGG
CAGCTGCTGG AGAGGAAGGT CCTAAGTACA GACAGGGTAC ATCTGCTAGA ACCGCCAGCC
CCCGGCATGG AGGATGAGGA AGAGCTGGAG ACCCGAGGGA ATCTTCGTCT GCTTTCAGCC
TTGGGTCTGT TTTGTGTGGG CTGGGAAGCC CCACAGGGTG TTGAGTTGCC TTCAGCCAAG
GATCTGGTGT TTGAGGAGGC CTGCGGGTAC TACCAGCGGC GGAGCCTGCG GGGTGCCCAG
CTCACTCCAG AAGAACTGAG ACACAGCAGC ACATTCCGGG CACCTCAGGC TCTGGCCTCC
ATCCTCCAGG GCCACCTGCC CCCATCTGCA CTGCTGACCA TGTTGAGGAC CGAGCTTCGG
GATTACCGAG GCTTAGAACA GCTGAAGGCC CAGCTGGTGG CTGGGGATGA TGAGGAGGCT
GGTTGGACTG AGCTGGCGGA GCAGGAAGTG GCACGCCTGC TGAGGACTGA GTTGATAGGA
GACCAGCTAG CCCAGCTCAA CACCGTTTTC CAAGCCCTTC CTACAGCAGC CTGGGGTGCC
ACCCTCAGGG CCCTGCAGCT CCAGCTAGAT GGGAATGGCA AGCTGAGGTC CCAAGCACCC
CCTGATGTGT GGAAGAAAGT GTTAGGGGGA ATAACCGCTG GAAAGGAACC CCCCAATGGA
ATACTGCCCC CCTTTGAACT CCTGTGCCAG TGTCTGTGCC AGCTGGAGCC TCGATGGCTG
CCACCCTTTG TGGAGCTGGC ACAGCAGCAG GGCGGGCCGG GCTGGGGGGC AGGGGGCCCA
GGACTGCCCC TGTATCGCCG AGCTCTGGCA GTGCTAGGTG AGGAGGGGAC CAGGCCTGAG
GCTCTGGAGC TAGAGCTGCT CTTGAGCAGT GGGCGGCCTA AAGCTGTGCT CCAAGCTGTC
GGGCAGCTGG TGCAAAAGGA ACAATGGGAT CGGGCTCTGG ATGCTGGCCT GGCCCTCGGC
CCCTCCAGTC CCCTGCTTCG AAGTGAAATC TTCAAACTGC TGCTGGCCGA GTTTGCCCAG
CACCGCCGGC TTGATGCTCA CCTCCCCCTC CTTTGCCGCC TGTGCCCACC AGAACTGGCT
CCAGCTGAGC TCCTGCTTCT ACTGAGGACA TACCTCCCAG ATGAGGTGGG GCCCCCAACC
CCATTCCCTG AGCCTGGAGC AGAGCCCCCT CTCACTGTGG GCTTGCTCAA AGCCCTGCTG
GAGCAGACTG GGGCTCAAGG ATGGCTGTCG GGCCCAGTTC TAAGCCCATA TGAGGACATC
CTATGGGACC CCAGCACTCC ACCCCCGACT CCACCTCGGG ACCTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_079023.2
CDS109..2436
Exon (1)1..2672
Gene:HPS6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_024747
Organism Homo sapiens (human)
Definition Homo sapiens Hermansky-Pudlak syndrome 6 (HPS6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024747

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
ATGAAGCGCT CGGGGACTCT GCGGCTGCTC TCGGACCTGA GCGCCTTCGG CGGCGCGGCG 
CGGCTCCGGG AGCTGGTGGC CGGGGACTCA GCGGTCCGAG TCCGTGGCAG TCCGGACGGC
CGCCACTTGC TGCTCCTGCG ACCCCCTGGG GCGGTAGCCC CACAGCTGCT AGTCGCGTCG
CGAGGGCCCG GCGCGGAGCT AGAGCGGGCC TGGCCGGCCG GCCAGCCCTC CCCGCTGGAC
GCCTTCTTCC TGCCGTGGCC AGCGCGGCCG GCGCTGGTGC TGGTGTGGGA GAGTGGCCTG
GCCGAGGTGT GGGGCGCGGG CGTGGGGCCT GGCTGGCGGC CGCTGCAGAG CACCGAGCTG
TGTCCGGGCG GGGGAGCCCG CGTTGTGGCA GTGGCGGCGC TCCGAGGCCG CCTGGTGTGG
TGCGAGGAGC GGCAGGCCCG GGCCGAGGGC CCGTCAGGGT CGCCAGCAGC CGCTTTCAGC
CACTGTGTGT GCGTCCGGAC TCTGGAGCCC AGCGGGGAAG CTAGCACCAG CCTGGGCCGC
ACACACGTCC TGCTGCACCA CTGCCCTGCC TTCGGGCTGC TGGCCTCCTG CAGACAACTC
TTCCTGGTGC CCACTGCCAC CACCTGGCCT GGCGTGGCCC ACGTTCTACT CATCTGGAGC
CCAGGCAAGG GCAAAGTGAT GGTGGCTGCC CCACGGCTTG GTCTCTCCTA CAGTAAGAGT
CTGAATCCTG GACGAGGGGA CACATGGGAC TTCCGGACCC TGCTCCGAGG CCTTCCTGGG
TTGCTGTCCC CCAGGGAGCC ACTGGCTGTA CACACCTGGG CCCCAACTCC CCAGGGCCTG
CTGTTGCTTG ACTTCGGGGG CACTGTGAGC CTATTGCAGT CCCACGGTGG TACGCGGGCT
GTGGGCACCC TGCAGGAGGC ACCTGTAGGC CCGTGGGGGT CTGCAGCCCT AGGCACATTT
CAGGGCACTC TGGCCTGTGT GCTGGGCTCC ACATTGGAAC TGCTGGACAT GGGCAGTGGG
CAGCTGCTGG AGAGGAAGGT CCTAAGTACA GACAGGGTAC ATCTGCTAGA ACCGCCAGCC
CCCGGCATGG AGGATGAGGA AGAGCTGGAG ACCCGAGGGA ATCTTCGTCT GCTTTCAGCC
TTGGGTCTGT TTTGTGTGGG CTGGGAAGCC CCACAGGGTG TTGAGTTGCC TTCAGCCAAG
GATCTGGTGT TTGAGGAGGC CTGCGGGTAC TACCAGCGGC GGAGCCTGCG GGGTGCCCAG
CTCACTCCAG AAGAACTGAG ACACAGCAGC ACATTCCGGG CACCTCAGGC TCTGGCCTCC
ATCCTCCAGG GCCACCTGCC CCCATCTGCA CTGCTGACCA TGTTGAGGAC CGAGCTTCGG
GATTACCGAG GCTTAGAACA GCTGAAGGCC CAGCTGGTGG CTGGGGATGA TGAGGAGGCT
GGTTGGACTG AGCTGGCGGA GCAGGAAGTG GCACGCCTGC TGAGGACTGA GTTGATAGGA
GACCAGCTAG CCCAGCTCAA CACCGTTTTC CAAGCCCTTC CTACAGCAGC CTGGGGTGCC
ACCCTCAGGG CCCTGCAGCT CCAGCTAGAT GGGAATGGCA AGCTGAGGTC CCAAGCACCC
CCTGATGTGT GGAAGAAAGT GTTAGGGGGA ATAACCGCTG GAAAGGAACC CCCCAATGGA
ATACTGCCCC CCTTTGAACT CCTGTGCCAG TGTCTGTGCC AGCTGGAGCC TCGATGGCTG
CCACCCTTTG TGGAGCTGGC ACAGCAGCAG GGCGGGCCGG GCTGGGGGGC AGGGGGCCCA
GGACTGCCCC TGTATCGCCG AGCTCTGGCA GTGCTAGGTG AGGAGGGGAC CAGGCCTGAG
GCTCTGGAGC TAGAGCTGCT CTTGAGCAGT GGGCGGCCTA AAGCTGTGCT CCAAGCTGTC
GGGCAGCTGG TGCAAAAGGA ACAATGGGAT CGGGCTCTGG ATGCTGGCCT GGCCCTCGGC
CCCTCCAGTC CCCTGCTTCG AAGTGAAATC TTCAAACTGC TGCTGGCCGA GTTTGCCCAG
CACCGCCGGC TTGATGCTCA CCTCCCCCTC CTTTGCCGCC TGTGCCCACC AGAACTGGCT
CCAGCTGAGC TCCTGCTTCT ACTGAGGACA TACCTCCCAG ATGAGGTGGG GCCCCCAACC
CCATTCCCTG AGCCTGGAGC AGAGCCCCCT CTCACTGTGG GCTTGCTCAA AGCCCTGCTG
GAGCAGACTG GGGCTCAAGG ATGGCTGTCG GGCCCAGTTC TAAGCCCATA TGAGGACATC
CTATGGGACC CCAGCACTCC ACCCCCGACT CCACCTCGGG ACCTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Targeting protein-trafficking pathways alters melanoma treatment sensitivity
Proc. Natl. Acad. Sci. U.S.A. 109 (2), 553-558 (2012)
Huang ZM, Chinen M, Chang PJ, Xie T, Zhong L, Demetriou S, Patel MP, Scherzer R, Sviderskaya EV, Bennett DC, Millhauser GL, Oh DH, Cleaver JE and Wei ML.


book

Clinical and cellular characterisation of Hermansky-Pudlak syndrome type 6
J. Med. Genet. 46 (12), 803-810 (2009)
Huizing M, Pederson B, Hess RA, Griffin A, Helip-Wooley A, Westbroek W, Dorward H, O'Brien KJ, Golas G, Tsilou E, White JG and Gahl WA.


book

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
Am. J. Hum. Genet. 78 (1), 78-88 (2006)
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J and Goate A.


book

Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6
Traffic 5 (4), 276-283 (2004)
Di Pietro SM, Falcon-Perez JM and Dell'Angelica EC.


book

Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6
Nat. Genet. 33 (2), 145-153 (2003)
Zhang Q, Zhao B, Li W, Oiso N, Novak EK, Rusiniak ME, Gautam R, Chintala S, O'Brien EP, Zhang Y, Roe BA, Elliott RW, Eicher EM, Liang P, Kratz C, Legius E, Spritz RA, O'Sullivan TN, Copeland NG, Jenkins NA and Swank RT.


book

Hermansky-Pudlak Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Gahl,W.A. and Huizing,M.


 
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