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CSRP3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CSRP3
Entrez Gene ID 8048
Full Name cysteine and glycine-rich protein 3 (cardiac LIM protein)
Synonyms CLP, CMD1M, CMH12, CRP3, LMO4, MLP
General protein information
Preferred Names
cysteine and glycine-rich protein 3
Names
cysteine and glycine-rich protein 3
LIM domain only 4
muscle LIM protein
cardiac LIM domain protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.1

Summary This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600824

Disorder Html: Cardiomyopathy, dilated, 1M, 607482 (3); Cardiomyopathy,

mRNA and Protein(s)

mRNA Protein Name
NM_003476 NP_003467 cysteine and glycine-rich protein 3


Homo sapiens (human) CSRP3 NP_003467.1
Pan troglodytes (chimpanzee) CSRP3 XP_528813.2
Macaca mulatta (Rhesus monkey) CSRP3 XP_001095430.1
Canis lupus familiaris (dog) CSRP3 XP_852328.1
Bos taurus (cattle) CSRP3 NP_001019860.1
Mus musculus (house mouse) Csrp3 NP_001185770.1
Rattus norvegicus (Norway rat) Csrp3 NP_476485.1
Gallus gallus (chicken) CSRP3 NP_001186415.1
Danio rerio (zebrafish) csrp3 NP_001006026.1
Drosophila melanogaster (fruit fly) Mlp60A NP_001137750.1
Xenopus (Silurana) tropicalis (western clawed frog) csrp3 NP_001006836.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CSRP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSRP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21723
NM_003476 Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIM protein) (CSRP3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21723
Clone ID Related Accession (Same CDS sequence) NM_003476
Accession Version NM_003476.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cysteine and glycine-rich protein 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC024010.1, AC009652.14, AJ711422.1 and AA192614.1. On or before Aug 31, 2013 this sequence version replaced gi:530395838, gi:189083752, gi:189083751. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024010.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2155550, SAMEA962337 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003467.1
CDS240..824
Misc Feature(1)93..95(+)
Misc Feature(2)264..425(+)
Misc Feature(3)267..422(+)
Misc Feature(4)429..446(+)
Misc Feature(5)597..758(+)
Misc Feature(6)597..752(+)
Exon (1)1..122
Gene:CSRP3
Gene Synonym:
Exon (2)123..211
Gene:CSRP3
Gene Synonym:
Exon (3)212..351
Gene:CSRP3
Gene Synonym:
Exon (4)352..520
Gene:CSRP3
Gene Synonym:
Exon (5)521..653
Gene:CSRP3
Gene Synonym:
Exon (6)654..747
Gene:CSRP3
Gene Synonym:
Exon (7)748..1464
Gene:CSRP3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003476
Organism Homo sapiens (human)
Definition Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIM protein) (CSRP3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003476

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
Mol. Cell. Biochem. 367 (1-2), 185-194 (2012)
Shi HJ, Wen JK, Miao SB, Liu Y and Zheng B.


book

A novel custom resequencing array for dilated cardiomyopathy
Genet. Med. 12 (5), 268-278 (2010)
Zimmerman RS, Cox S, Lakdawala NK, Cirino A, Mancini-DiNardo D, Clark E, Leon A, Duffy E, White E, Baxter S, Alaamery M, Farwell L, Weiss S, Seidman CE, Seidman JG, Ho CY, Rehm HL and Funke BH.


book

Common susceptibility variants examined for association with dilated cardiomyopathy
Ann. Hum. Genet. 74 (2), 110-116 (2010)
Rampersaud E, Kinnamon DD, Hamilton K, Khuri S, Hershberger RE and Martin ER.


book

Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
Mol. Cell. Biol. 17 (8), 4750-4760 (1997)
Kong Y, Flick MJ, Kudla AJ and Konieczny SF.


book

Characterization of a human cardiac gene which encodes for a LIM domain protein and is developmentally expressed in myocardial development
J. Mol. Cell. Cardiol. 28 (6), 1203-1210 (1996)
Fung YW, Wang R and Liew CC.


book

The cysteine-rich protein family of highly related LIM domain proteins
J. Biol. Chem. 270 (48), 28946-28954 (1995)
Weiskirchen R, Pino JD, Macalma T, Bister K and Beckerle MC.


book

Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization
Genomics 28 (3), 602-603 (1995)
Fung YW, Wang RX, Heng HH and Liew CC.


book

Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation
Cell 79 (2), 221-231 (1994)
Arber S, Halder G and Caroni P.


book

Hypertrophic Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Cirino,A.L. and Ho,C.


book

Dilated Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Hershberger,R.E. and Morales,A.


 
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