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CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) [Homo sapiens (human)]

Gene Symbol CSRP3
Entrez Gene ID 8048
Full Name cysteine and glycine-rich protein 3 (cardiac LIM protein)
Synonyms CLP, CMD1M, CMH12, CRP3, LMO4, MLP
General protein information
Preferred Names
cysteine and glycine-rich protein 3
Names
cysteine and glycine-rich protein 3
LIM domain only 4
muscle LIM protein
cardiac LIM domain protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.1

Summary This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600824

Disorder Html: Cardiomyopathy, dilated, 1M, 607482 (3); Cardiomyopathy,





The following CSRP3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSRP3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21723 NM_003476 Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIM protein) (CSRP3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu21723
Accession Version NM_003476.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu21723D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cysteine and glycine-rich protein 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC024010.1, AC009652.14, AJ711422.1 and AA192614.1. On or before Aug 31, 2013 this sequence version replaced gi:530395838, gi:189083752, gi:189083751. Summary: This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024010.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2155550, SAMEA962337 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003467.1
CDS240..824
Misc Feature(1)93..95(+)
Misc Feature(2)264..425(+)
Misc Feature(3)267..422(+)
Misc Feature(4)429..446(+)
Misc Feature(5)597..758(+)
Misc Feature(6)597..752(+)
Exon (1)1..122
Gene:CSRP3
Gene Synonym:
Exon (2)123..211
Gene:CSRP3
Gene Synonym:
Exon (3)212..351
Gene:CSRP3
Gene Synonym:
Exon (4)352..520
Gene:CSRP3
Gene Synonym:
Exon (5)521..653
Gene:CSRP3
Gene Synonym:
Exon (6)654..747
Gene:CSRP3
Gene Synonym:
Exon (7)748..1464
Gene:CSRP3
Gene Synonym:
Translation
Position Chain Variation Link
9 9 a, g dbSNP:113140918
14 14 c, t dbSNP:563993867
28 28 c, t dbSNP:776757322
29 29 c, t dbSNP:183992670
45 45 a, g dbSNP:569978006
60 60 -, a dbSNP:34865888
76 76 -, aaa dbSNP:778256417
76 76 -, aa dbSNP:763575628
76 76 -, a dbSNP:769956179
77 77 -, aa, g dbSNP:61238046
77 77 a, g dbSNP:112672382
78 78 a, g dbSNP:558218559
79 79 -, g dbSNP:138573509
135 135 a, g dbSNP:563432277
140 140 c, t dbSNP:545265371
152 152 a, g dbSNP:727502947
156 156 a, g dbSNP:727504617
166 166 a, c dbSNP:45498797
170 170 c, t dbSNP:147388951
183 183 a, g dbSNP:541052548
194 194 c, t dbSNP:373296490
195 195 g, t dbSNP:555496937
209 209 a, c dbSNP:537504368
219 219 a, c dbSNP:768173909
225 225 c, t dbSNP:760049800
229 229 c, t dbSNP:774006811
237 237 a, c dbSNP:760384315
244 244 a, c dbSNP:762730416
249 249 c, t dbSNP:45550635
252 252 c, g dbSNP:769677095
254 254 c, t dbSNP:747959696
255 255 a, g dbSNP:185980145
259 259 g, t dbSNP:768595166
260 260 c, t dbSNP:151177504
261 261 a, g dbSNP:45531937
268 268 a, g dbSNP:141980088
277 277 a, g dbSNP:182726860
279 279 c, g dbSNP:777883490
281 281 a, g dbSNP:756368977
286 286 c, t dbSNP:397516857
287 287 c, t dbSNP:753120437
288 288 -, gtctacc dbSNP:776444956
288 288 a, g dbSNP:767932680
291 291 -, t dbSNP:759305806
294 294 c, g dbSNP:375525973
311 311 -, g dbSNP:766395852
313 313 g, t dbSNP:190182843
324 324 a, c dbSNP:765951170
325 325 a, g dbSNP:372717179
329 329 c, t dbSNP:772727223
337 337 c, t dbSNP:758947977
338 338 a, g dbSNP:147549410
347 347 c, t dbSNP:763193066
348 348 c, t dbSNP:776468900
349 349 -, g dbSNP:760600548
351 351 a, c dbSNP:768436996
353 353 c, g dbSNP:769986102
355 355 c, g dbSNP:748417030
359 359 c, t dbSNP:112884796
370 370 c, t dbSNP:104894205
375 375 a, c dbSNP:137852765
377 377 a, c dbSNP:747363563
379 379 c, t dbSNP:397516851
380 380 a, g dbSNP:758842207
386 386 c, t dbSNP:576346189
387 387 a, g dbSNP:145300736
388 388 c, t dbSNP:139805841
389 389 a, g dbSNP:7124801
391 391 a, c, g, t dbSNP:397516853
392 392 c, t dbSNP:752452689
394 394 a, t dbSNP:767326021
399 399 agggg, tcgga dbSNP:281865416
400 400 c, t dbSNP:759455306
401 401 a, g dbSNP:112848043
403 403 a, g dbSNP:267606753
405 405 a, g dbSNP:770041119
407 407 c, g dbSNP:767360228
408 408 c, t dbSNP:374764059
411 411 g, t dbSNP:104894204
414 414 a, g dbSNP:769003538
422 422 c, t dbSNP:34075817
429 429 a, c, t dbSNP:368392588
430 430 a, g dbSNP:375014380
436 436 a, g dbSNP:397516854
437 437 c, t dbSNP:779421059
440 440 c, t dbSNP:557643642
444 444 a, c dbSNP:539656337
445 445 a, g dbSNP:137852764
447 447 g, t dbSNP:777211110
451 451 c, t dbSNP:755784426
452 452 c, t dbSNP:45476991
453 453 a, g dbSNP:45552933
455 455 a, g, t dbSNP:751348376
455 455 -, g dbSNP:772117382
458 458 c, t dbSNP:397516852
461 461 a, c dbSNP:762915899
462 462 a, c dbSNP:776862812
467 467 c, t dbSNP:768767452
468 468 a, g, t dbSNP:746207
469 469 c, g dbSNP:772138289
475 475 c, g dbSNP:199793773
477 477 c, t dbSNP:779184695
479 479 c, t dbSNP:771444930
490 490 c, g, t dbSNP:777327517
491 491 a, g dbSNP:755614464
494 494 c, t dbSNP:752338221
495 495 a, g dbSNP:780917755
497 497 a, g dbSNP:182798086
500 500 c, t dbSNP:773476497
503 503 a, c, t dbSNP:758256351
504 504 a, g, t dbSNP:367827746
508 508 c, t dbSNP:760832923
509 509 a, g dbSNP:774366633
511 511 a, t dbSNP:727504436
521 521 g, t dbSNP:550097061
523 523 c, t dbSNP:767477787
524 524 a, c, g dbSNP:45483799
525 525 c, t dbSNP:774530670
526 526 c, t dbSNP:766783066
530 530 a, g dbSNP:763334172
532 532 c, t dbSNP:773411006
533 533 a, g dbSNP:142832902
537 537 c, t dbSNP:201214593
538 538 a, g dbSNP:138218523
539 539 c, t dbSNP:146290726
541 541 c, t dbSNP:746707959
545 545 c, t dbSNP:779874019
550 550 c, t dbSNP:758083208
551 551 c, g dbSNP:45582433
566 566 a, g dbSNP:778512127
573 573 c, g dbSNP:727504905
574 574 a, c, t dbSNP:753711278
575 575 a, c, g dbSNP:13451
583 583 a, g dbSNP:143384148
590 590 c, t dbSNP:766621810
591 591 a, g dbSNP:763096875
595 595 a, g dbSNP:750815304
598 598 a, g dbSNP:765507249
604 604 a, g dbSNP:193922667
617 617 a, c dbSNP:776972578
618 618 a, g dbSNP:149201422
625 625 c, g, t dbSNP:760292738
643 643 -, g dbSNP:35210858
647 647 a, t dbSNP:775072134
648 648 g, t dbSNP:771861706
660 660 c, g dbSNP:771700174
673 673 g, t dbSNP:759269008
674 674 c, t dbSNP:773848388
675 675 c, t dbSNP:376198883
676 676 a, g, t dbSNP:377066670
685 685 a, t dbSNP:777480588
688 688 a, g dbSNP:761507504
695 695 a, g dbSNP:397516856
696 696 -, ag dbSNP:748393033
701 701 g, t dbSNP:71486897
704 704 a, g dbSNP:200334242
706 706 c, t dbSNP:758379114
720 720 c, g dbSNP:138254181
728 728 c, t dbSNP:746150722
735 735 c, g dbSNP:150114628
747 747 c, g dbSNP:757433657
750 750 c, t dbSNP:770760020
752 752 c, t dbSNP:376799144
755 755 c, t dbSNP:727504575
755 755 -, t dbSNP:756715438
758 758 c, t dbSNP:749515242
763 763 a, c dbSNP:370147131
768 768 a, g dbSNP:778319057
771 771 c, g, t dbSNP:749002955
772 772 c, t dbSNP:767944340
773 773 c, g dbSNP:755450152
774 774 a, g dbSNP:397516859
775 775 c, t dbSNP:142019584
777 777 g, t dbSNP:547374738
778 778 g, t dbSNP:727504899
783 783 c, g dbSNP:111868331
794 794 c, t dbSNP:765066102
800 800 a, g dbSNP:181530945
804 804 c, t dbSNP:776339605
807 807 g, t dbSNP:145073736
815 815 c, g dbSNP:141100524
818 818 -, agaa dbSNP:727502946
819 819 c, g dbSNP:571722496
822 822 c, t dbSNP:774359383
823 823 a, g dbSNP:372220068
830 830 c, t dbSNP:749568462
831 831 a, g dbSNP:189477598
832 832 c, t dbSNP:368444918
833 833 a, g dbSNP:531722178
835 835 c, g dbSNP:748531257
836 836 a, g dbSNP:45607943
839 839 c, t dbSNP:111525588
849 849 c, t dbSNP:755498404
850 850 c, t dbSNP:752103761
851 851 -, t dbSNP:534055346
853 853 c, t dbSNP:779471970
854 854 g, t dbSNP:757882490
869 869 g, t dbSNP:749887485
929 929 c, t dbSNP:751301106
952 952 g, t dbSNP:766143757
976 976 a, g dbSNP:45595441
982 982 a, g dbSNP:552831804
998 998 c, t dbSNP:45597034
1069 1069 c, t dbSNP:369635973
1086 1086 a, g dbSNP:542558419
1091 1091 a, g dbSNP:528830511
1113 1113 c, t dbSNP:773016212
1138 1138 a, c dbSNP:768779880
1165 1165 c, t dbSNP:758360773
1192 1192 g, t dbSNP:747195431
1215 1215 c, t dbSNP:184669824
1233 1233 c, t dbSNP:563331791
1239 1239 a, g dbSNP:180844111
1253 1253 -, t dbSNP:746387631
1274 1274 g, t dbSNP:45479995
1284 1284 a, g dbSNP:545629631
1383 1383 a, g dbSNP:45606836
1436 1436 c, t dbSNP:147897204
1437 1437 a, g dbSNP:553621998
1447 1447 c, t dbSNP:188117175
1453 1453 c, t dbSNP:45599440
1462 1462 c, t dbSNP:779532194

Target ORF information:

RefSeq Version NM_003476
Organism Homo sapiens (human)
Definition Homo sapiens cysteine and glycine-rich protein 3 (cardiac LIM protein) (CSRP3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003476

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCCAAACT GGGGCGGAGG CGCAAAATGT GGAGCCTGTG AAAAGACCGT CTACCATGCA 
GAAGAAATCC AGTGCAATGG AAGGAGTTTC CACAAGACGT GTTTCCACTG CATGGCCTGC
AGGAAGGCTC TTGACAGCAC GACAGTCGCG GCTCATGAGT CGGAGATCTA CTGCAAGGTG
TGCTATGGGC GCAGATATGG CCCCAAAGGG ATCGGGTATG GACAAGGCGC TGGCTGTCTC
AGCACAGACA CGGGCGAGCA TCTCGGCCTG CAGTTCCAAC AGTCCCCAAA GCCGGCACGC
TCAGTTACCA CCAGCAACCC TTCCAAATTC ACTGCGAAGT TTGGAGAGTC CGAGAAGTGC
CCTCGATGTG GCAAGTCAGT CTATGCTGCT GAGAAGGTTA TGGGAGGTGG CAAGCCTTGG
CACAAGACCT GTTTCCGCTG TGCCATCTGT GGGAAGAGTC TGGAGTCCAC AAATGTCACT
GACAAAGATG GGGAACTTTA TTGCAAAGTT TGCTATGCCA AAAATTTTGG CCCCACGGGT
ATTGGGTTTG GAGGCCTTAC ACAACAAGTG GAAAAGAAAG AATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.