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HIST1H2AL cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H2AL
Entrez Gene ID 8332
Full Name histone cluster 1, H2al
Synonyms H2A.i, H2A/i, H2AFI, dJ193B12.9
General protein information
Preferred Names
histone H2A type 1
Names
histone H2A type 1
H2A.1
histone 1, H2al
H2A histone family, member I
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.1

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602793


mRNA and Protein(s)

mRNA Protein Name
NM_003511 NP_003502 histone H2A type 1



Homo sapiens (human) HIST1H2AL NP_003502.1
Pan troglodytes (chimpanzee) LOC471894 XP_527272.2
Macaca mulatta (Rhesus monkey) LOC705469 XP_001097227.1
Bos taurus (cattle) LOC524176 XP_005215080.1
Mus musculus (house mouse) Hist1h2ae NP_835494.1
Rattus norvegicus (Norway rat) Hist1h2ah XP_006254039.1

The following HIST1H2AL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2AL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu13075
NM_003511 Homo sapiens histone cluster 1, H2al (HIST1H2AL), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu13075
Clone ID Related Accession (Same CDS sequence) NM_003511
Accession Version NM_003511.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 393bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H2A type 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X83549.1. On Sep 21, 2001 this sequence version replaced gi:4504242. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC069306.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGTCGGGAC GCGGCAAGCA GGGAGGCAAA GCTCGCGCCA AAGCCAAGAC CCGCTCTTCT 
CGTGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAT
GCTGAGCGGG TCGGGGCCGG CGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACT
GCCGAGATCC TGGAGCTGGC GGGCAACGCC GCCCGCGACA ACAAGAAGAC CCGCATTATC
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA
GTAACCATCG CTCAGGGTGG TGTCCTGCCC AACATCCAGG CTGTGCTACT GCCCAAGAAG
ACCGAGAGTC ACCACAAGGC CAAAGGCAAA TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003502.1
CDS27..419
Misc Feature(1)27..416(+)
Misc Feature(2)30..32(+)
Misc Feature(3)30..32(+)
Misc Feature(4)36..38(+)
Misc Feature(5)36..38(+)
Misc Feature(6)42..386(+)
Misc Feature(7)42..56(+)
Misc Feature(8)42..44(+)
Misc Feature(9)114..260(+)
Misc Feature(10)135..137(+)
Misc Feature(11)141..152(+)
Misc Feature(12)180..218(+)
Misc Feature(13)339..341(+)
Misc Feature(14)381..383(+)
Misc Feature(15)384..386(+)
Misc Feature(16)384..386(+)
Misc Feature(17)387..389(+)
Misc Feature(18)393..395(+)
Misc Feature(19)402..404(+)
Exon (1)1..470
Gene:HIST1H2AL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003511
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H2al (HIST1H2AL), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003511

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGTCGGGAC GCGGCAAGCA GGGAGGCAAA GCTCGCGCCA AAGCCAAGAC CCGCTCTTCT 
CGTGCCGGTC TCCAGTTCCC CGTGGGCCGA GTGCACCGAC TGCTCCGCAA GGGCAACTAT
GCTGAGCGGG TCGGGGCCGG CGCGCCGGTG TACCTGGCGG CGGTGCTGGA GTACCTGACT
GCCGAGATCC TGGAGCTGGC GGGCAACGCC GCCCGCGACA ACAAGAAGAC CCGCATTATC
CCGCGCCACT TGCAGCTGGC CATCCGCAAC GACGAGGAGC TCAACAAGCT GCTGGGCAAA
GTAACCATCG CTCAGGGTGG TGTCCTGCCC AACATCCAGG CTGTGCTACT GCCCAAGAAG
ACCGAGAGTC ACCACAAGGC CAAAGGCAAA TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
FEBS Lett. 588 (21), 3844-3854 (2014)
Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M and Glass KC.


book

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
Proteomics 13 (10-11), 1667-1671 (2013)
Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T and Drake RR.


book

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase
J. Biol. Chem. 287 (8), 5278-5289 (2012)
Kim W, Chakraborty G, Kim S, Shin J, Park CH, Jeong MW, Bharatham N, Yoon HS and Kim KT.


book

Proteomic characterization of the human sperm nucleus
Proteomics 11 (13), 2714-2726 (2011)
de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.


book

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis
FEBS J. 277 (16), 3321-3342 (2010)
Pozuelo-Rubio M.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter
Mol. Cell. Biol. 18 (5), 2535-2544 (1998)
El Kharroubi A, Piras G, Zensen R and Martin MA.


book

The human histone gene cluster at the D6S105 locus
Hum. Genet. 101 (3), 284-294 (1997)
Albig W and Doenecke D.


book

Characterization of the H1.5 gene completes the set of human H1 subtype genes
Gene 184 (2), 141-148 (1997)
Albig W, Meergans T and Doenecke D.


book

Definition of a C-reactive protein binding determinant on histones
J. Biol. Chem. 266 (4), 2167-2171 (1991)
Du Clos TW, Zlock LT and Marnell L.


 
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