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HIST1H2BG cDNA ORF clone, Homo sapiens (human)

Gene Symbol HIST1H2BG
Entrez Gene ID 8339
Full Name histone cluster 1, H2bg
Synonyms H2B.1A, H2B/a, H2BFA, dJ221C16.8
General protein information
Preferred Names
histone H2B type 1-C/E/F/G/I
Names
histone H2B type 1-C/E/F/G/I
histone H2B.a
histone 1, H2bg
histone H2B.1 A
H2B histone family, member A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.2

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602798

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_003518 NP_003509 histone H2B type 1-C/E/F/G/I

KEGG
hsa05322 Systemic lupus erythematosus
hsa05203 Viral carcinogenesis
hsa05034 Alcoholism
Reactome
R-HSA-1643685 Disease
R-HSA-977225 Amyloid formation
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-195721 Signaling by Wnt
R-HSA-74160 Gene Expression
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-1640170 Cell Cycle
R-HSA-211000 Gene Silencing by RNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-427359 SIRT1 negatively regulates rRNA Expression
R-HSA-5334118 DNA methylation
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-69481 G2/M Checkpoints
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-1500620 Meiosis
R-HSA-1221632 Meiotic synapsis
R-HSA-157579 Telomere Maintenance
R-HSA-912446 Meiotic recombination
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-73886 Chromosome Maintenance
R-HSA-774815 Nucleosome assembly
R-HSA-2262752 Cellular responses to stress
R-HSA-4839726 Chromatin organization
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3214847 HATs acetylate histones
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-3214815 HDACs deacetylate histones


Homo sapiens (human) HIST1H2BG NP_003509.1
Pan troglodytes (chimpanzee) LOC100610052 XP_003311104.1
Macaca mulatta (Rhesus monkey) LOC696996 XP_001086637.2
Macaca mulatta (Rhesus monkey) LOC696506 XP_001086167.1
Macaca mulatta (Rhesus monkey) LOC696808 XP_002803690.1
Macaca mulatta (Rhesus monkey) LOC697857 XP_001087459.1
Macaca mulatta (Rhesus monkey) LOC697469 XP_001087112.1
Canis lupus familiaris (dog) LOC611482 XP_854244.1
Bos taurus (cattle) LOC787465 XP_005223854.1
Mus musculus (house mouse) Hist1h2bf NP_835502.1
Rattus norvegicus (Norway rat) Hist1h2bf XP_225384.1


The following HIST1H2BG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2BG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30077
NM_003518 Homo sapiens histone cluster 1, H2bg (HIST1H2BG), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.30
$99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu30077
Accession Version NM_003518.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H2B type 1-C/E/F/G/I
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M60750.1. On Jun 21, 2002 this sequence version replaced gi:19923172. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12860195 replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGCCTGAAC CAGCTAAGTC AGCTCCTGCT CCGAAGAAGG GTTCCAAGAA GGCTGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGC AAGCGCAGTC GTAAGGAGAG CTACTCCGTG
TATGTGTACA AGGTGCTAAA ACAGGTTCAC CCCGATACTG GCATCTCATC CAAGGCCATG
GGCATCATGA ATTCCTTCGT TAACGACATC TTCGAACGCA TCGCAGGCGA GGCTTCCCGT
CTGGCCCACT ACAACAAGCG CTCGACCATT ACCTCCAGGG AGATCCAGAC CGCCGTGCGT
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCAGTGTCCG AAGGTACCAA GGCTGTCACC
AAGTATACAA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_003509.1
CDS2..382
Misc Feature(1)5..7(+)
Misc Feature(2)17..19(+)
Misc Feature(3)17..19(+)
Misc Feature(4)35..37(+)
Misc Feature(5)35..37(+)
Misc Feature(6)38..40(+)
Misc Feature(7)38..40(+)
Misc Feature(8)44..46(+)
Misc Feature(9)47..49(+)
Misc Feature(10)47..49(+)
Misc Feature(11)50..52(+)
Misc Feature(12)50..52(+)
Misc Feature(13)62..64(+)
Misc Feature(14)62..64(+)
Misc Feature(15)71..73(+)
Misc Feature(16)71..73(+)
Misc Feature(17)83..373(+)
Misc Feature(18)104..106(+)
Misc Feature(19)110..112(+)
Misc Feature(20)140..142(+)
Misc Feature(21)173..175(+)
Misc Feature(22)239..241(+)
Misc Feature(23)257..259(+)
Misc Feature(24)257..259(+)
Misc Feature(25)260..262(+)
Misc Feature(26)278..280(+)
Misc Feature(27)326..328(+)
Misc Feature(28)347..349(+)
Misc Feature(29)350..352(+)
Exon (1)1..445
Gene:HIST1H2BG
Gene Synonym:
Translation
Position Chain Variation Link
1 1 c, t dbSNP:776934484
4 4 a, g, t dbSNP:148814957
6 6 c, g dbSNP:773203416
7 7 c, t dbSNP:771976174
10 10 a, g dbSNP:372673859
11 11 a, c, g dbSNP:191008734
12 12 c, t dbSNP:202162061
14 14 a, c, g dbSNP:769401291
15 15 c, g, t dbSNP:778162085
16 16 c, t dbSNP:758732493
21 21 a, c, g, t dbSNP:145524593
24 24 c, t dbSNP:753793487
25 25 g, t dbSNP:368880863
26 26 c, t dbSNP:149681157
27 27 c, t dbSNP:575981224
29 29 c, g, t dbSNP:761654812
30 30 c, t dbSNP:114698706
32 32 c, g, t dbSNP:146860350
35 35 a, c dbSNP:774920524
37 37 -, c dbSNP:765204307
37 37 a, g dbSNP:769327331
40 40 c, g dbSNP:745560922
41 41 a, g dbSNP:780781537
46 46 c, t dbSNP:143774290
55 55 c, t dbSNP:748454377
58 58 g, t dbSNP:779477632
60 60 c, g dbSNP:755499900
61 61 c, g, t dbSNP:144645222
63 63 a, g dbSNP:756229739
65 65 a, c, g, t dbSNP:146142074
66 66 a, c, t dbSNP:142815649
69 69 a, g dbSNP:763936797
74 74 -, aag dbSNP:763480943
76 76 a, g dbSNP:762848033
81 81 -, g dbSNP:753597313
85 85 a, g dbSNP:775468179
88 88 g, t dbSNP:769326895
92 92 a, c dbSNP:758995956
94 94 a, g dbSNP:533938487
103 103 c, t dbSNP:770502877
106 106 a, g dbSNP:751156445
112 112 c, t dbSNP:117226020
115 115 c, t dbSNP:769039154
119 119 g, t dbSNP:749796846
120 120 c, t dbSNP:780568228
121 121 c, g dbSNP:756278826
124 124 c, t dbSNP:745879206
125 125 g, t dbSNP:781421534
127 127 a, c, g, t dbSNP:555818951
129 129 a, g dbSNP:758174332
132 132 a, g dbSNP:752597600
136 136 a, g dbSNP:765100725
140 140 a, t dbSNP:759051084
143 143 c, t dbSNP:376254420
151 151 c, t dbSNP:765857790
155 155 a, g dbSNP:760291254
163 163 c, t dbSNP:772886682
166 166 a, c, g dbSNP:749610657
172 172 c, t dbSNP:140919872
175 175 a, g dbSNP:372917727
176 176 a, g dbSNP:746368662
177 177 c, t dbSNP:781470850
178 178 c, t dbSNP:762435555
179 179 a, g dbSNP:200965546
190 190 g, t dbSNP:747228517
191 191 -, t dbSNP:766192153
196 196 a, c dbSNP:778005479
199 199 c, t dbSNP:570046076
208 208 c, t dbSNP:752469309
211 211 a, c, t dbSNP:374281578
217 217 a, g, t dbSNP:41266811
218 218 c, t dbSNP:765911190
219 219 c, g dbSNP:760189973
221 221 a, t dbSNP:772758945
223 223 c, t dbSNP:767133701
229 229 c, t dbSNP:761370253
233 233 a, g dbSNP:776059675
234 234 c, g dbSNP:770265113
239 239 a, c, t dbSNP:777238838
240 240 g, t dbSNP:779443828
241 241 c, t dbSNP:770940533
242 242 c, t dbSNP:747050536
244 244 g, t dbSNP:777861065
247 247 c, g dbSNP:772404532
248 248 c, t dbSNP:748304068
250 250 c, t dbSNP:778724341
253 253 a, c, g, t dbSNP:369376110
255 255 a, g dbSNP:755586518
256 256 c, t dbSNP:750019670
259 259 a, g dbSNP:202170052
261 261 a, g dbSNP:761580046
262 262 c, g dbSNP:751225846
265 265 a, g dbSNP:765729377
267 267 c, t dbSNP:759933007
269 269 a, g dbSNP:375561975
277 277 a, c, t dbSNP:201957387
280 280 a, g dbSNP:139135890
285 285 g, t dbSNP:772022131
286 286 c, g dbSNP:748405525
288 288 a, c dbSNP:779063580
289 289 a, g, t dbSNP:16891427
292 292 c, t dbSNP:372346685
295 295 a, c, t dbSNP:756138373
296 296 a, g, t dbSNP:368649575
298 298 a, g dbSNP:143613920
302 302 c, t dbSNP:377201962
313 313 c, g dbSNP:371778293
331 331 c, t dbSNP:751280874
332 332 a, g dbSNP:367765460
337 337 a, g dbSNP:763783564
340 340 c, t dbSNP:186981469
352 352 a, g dbSNP:138214841
353 353 c, g dbSNP:754320179
355 355 -, t dbSNP:760271385
358 358 c, t dbSNP:766638514
361 361 c, g, t dbSNP:773561876
364 364 a, g dbSNP:767666925
367 367 c, t dbSNP:761831024
372 372 a, g dbSNP:774567730
374 374 a, t dbSNP:768934674
376 376 c, t dbSNP:182318715
381 381 a, g dbSNP:775404879
384 384 c, t dbSNP:199951228
385 385 g, t dbSNP:745853955
387 387 a, g dbSNP:780946079
388 388 a, t dbSNP:772220232
389 389 g, t dbSNP:746456357
391 391 c, t dbSNP:777415026
392 392 c, t dbSNP:548265162
396 396 c, t dbSNP:752372359
398 398 c, g, t dbSNP:374205944
401 401 c, t dbSNP:750962368
406 406 c, g dbSNP:767852202
407 407 c, t dbSNP:200940163
408 408 -, t dbSNP:771418876
408 408 c, g, t dbSNP:764137342
410 410 -, aa dbSNP:770067645
412 412 a, g dbSNP:370513998
416 416 c, g dbSNP:775535861
420 420 a, t dbSNP:201937698
423 423 g, t dbSNP:745595914
427 427 c, t dbSNP:776637442
428 428 a, g dbSNP:771056248
429 429 c, t dbSNP:746926779
431 431 c, t dbSNP:759761140
433 433 a, c dbSNP:777471534
436 436 c, t dbSNP:189690437
441 441 a, g dbSNP:28448296

Target ORF information:

RefSeq Version NM_003518
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H2bg (HIST1H2BG), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003518

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGCCTGAAC CAGCTAAGTC AGCTCCTGCT CCGAAGAAGG GTTCCAAGAA GGCTGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGC AAGCGCAGTC GTAAGGAGAG CTACTCCGTG
TATGTGTACA AGGTGCTAAA ACAGGTTCAC CCCGATACTG GCATCTCATC CAAGGCCATG
GGCATCATGA ATTCCTTCGT TAACGACATC TTCGAACGCA TCGCAGGCGA GGCTTCCCGT
CTGGCCCACT ACAACAAGCG CTCGACCATT ACCTCCAGGG AGATCCAGAC CGCCGTGCGT
CTGCTGCTTC CCGGAGAGCT GGCCAAGCAC GCAGTGTCCG AAGGTACCAA GGCTGTCACC
AAGTATACAA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
J Proteomics 82, 193-229 (2013)
Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P and Moll S.


book

Proteomic characterization of the human sperm nucleus
Proteomics 11 (13), 2714-2726 (2011)
de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.


book

Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells
Biochem. Biophys. Res. Commun. 404 (1), 428-433 (2011)
Gao Z and Xu CW.


book

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
Immunol. Cell Biol. 88 (8), 851-856 (2010)
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and Stoorvogel W.


book

The human and mouse replication-dependent histone genes
Genomics 80 (5), 487-498 (2002)
Marzluff WF, Gongidi P, Woods KR, Jin J and Maltais LJ.


book

Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay
Biochim. Biophys. Acta 1296 (2), 219-227 (1996)
Diaz-Jullien C, Perez-Estevez A, Covelo G and Freire M.


book

Biochemical and antibacterial analysis of human wound and blister fluid
Eur. J. Biochem. 237 (1), 86-92 (1996)
Frohm M, Gunne H, Bergman AC, Agerberth B, Bergman T, Boman A, Liden S, Jornvall H and Boman HG.


book

Isolation and characterization of two human H1 histone genes within clusters of core histone genes
Genomics 10 (4), 940-948 (1991)
Albig W, Kardalinou E, Drabent B, Zimmer A and Doenecke D.


book

Human spleen histone H2B. Isolation and amino acid sequence
J. Biochem. 85 (2), 615-624 (1979)
Ohe,Y., Hayashi,H. and Iwai,K.


 
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