Email to GenScript

HIST1H2BE histone cluster 1, H2be [Homo sapiens (human)]

Gene Symbol HIST1H2BE
Entrez Gene ID 8344
Full Name histone cluster 1, H2be
Synonyms H2B.h, H2B/h, H2BFH, dJ221C16.8
General protein information
Preferred Names
histone H2B type 1-C/E/F/G/I
Names
histone H2B type 1-C/E/F/G/I
histone H2B.h
histone 1, H2be
histone H2B.1 A
H2B histone family, member H
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p22.2

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

602805

Disorder Html:





The following HIST1H2BE gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H2BE gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu30268 NM_003523 Homo sapiens histone cluster 1, H2be (HIST1H2BE), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu30268
Accession Version NM_003523.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 381bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H2B type 1-C/E/F/G/I
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z80780.1. On Jun 12, 2002 this sequence version replaced gi:4504266. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BP362977.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12860195 replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGCCTGAGC CAGCGAAATC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCCGTGACC 
AAGGCGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTA
TACGTGTACA AGGTGCTGAA ACAGGTCCAC CCCGACACCG GCATCTCCTC TAAAGCCATG
GGGATCATGA ATTCCTTTGT CAACGACATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC
CTGCTGCTTC CCGGGGAGCT GGCCAAGCAC GCTGTGTCAG AGGGCACCAA GGCCGTTACC
AAGTACACCA GCTCCAAGTA A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_003514.2
CDS1..381
Misc Feature(1)4..6(+)
Misc Feature(2)16..18(+)
Misc Feature(3)16..18(+)
Misc Feature(4)34..36(+)
Misc Feature(5)34..36(+)
Misc Feature(6)37..39(+)
Misc Feature(7)37..39(+)
Misc Feature(8)43..45(+)
Misc Feature(9)46..48(+)
Misc Feature(10)46..48(+)
Misc Feature(11)49..51(+)
Misc Feature(12)49..51(+)
Misc Feature(13)61..63(+)
Misc Feature(14)61..63(+)
Misc Feature(15)70..72(+)
Misc Feature(16)70..72(+)
Misc Feature(17)82..372(+)
Misc Feature(18)103..105(+)
Misc Feature(19)109..111(+)
Misc Feature(20)139..141(+)
Misc Feature(21)172..174(+)
Misc Feature(22)238..240(+)
Misc Feature(23)256..258(+)
Misc Feature(24)256..258(+)
Misc Feature(25)259..261(+)
Misc Feature(26)277..279(+)
Misc Feature(27)325..327(+)
Misc Feature(28)346..348(+)
Misc Feature(29)349..351(+)
Exon (1)1..435
Gene:HIST1H2BE
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, g dbSNP:201385344
11 11 c, t dbSNP:148688357
14 14 c, t dbSNP:779045512
15 15 a, g dbSNP:748257611
18 18 a, g dbSNP:16891375
20 20 a, c, g, t dbSNP:146757427
20 20 -, c dbSNP:752665647
21 21 a, c, t dbSNP:776953714
25 25 a, c dbSNP:769731925
27 27 c, t dbSNP:773930099
29 29 -, c dbSNP:777660004
32 32 c, g dbSNP:145468173
33 33 -, gaa dbSNP:746971809
34 34 -, a dbSNP:770740234
35 35 a, g dbSNP:761539054
36 36 a, g dbSNP:767067699
37 37 a, g dbSNP:749976400
41 41 a, g dbSNP:368968049
42 42 c, t dbSNP:371930376
44 44 c, g dbSNP:753645222
45 45 c, t dbSNP:754785922
47 47 a, g dbSNP:779190019
48 48 a, c, g dbSNP:748248883
51 51 a, g, t dbSNP:570095612
52 52 a, g dbSNP:374387585
54 54 a, c, g dbSNP:777712658
57 57 a, g dbSNP:529756458
58 58 a, g dbSNP:775938262
59 59 c, g dbSNP:61978632
60 60 c, t dbSNP:141005448
66 66 a, g dbSNP:371699016
67 67 c, t dbSNP:760309477
68 68 -, aga dbSNP:549755584
75 75 a, g, t dbSNP:374653390
79 79 a, g dbSNP:7766641
81 81 c, g, t dbSNP:764880184
86 86 a, c dbSNP:758574968
89 89 a, g, t dbSNP:552518996
94 94 c, t dbSNP:751629438
99 99 c, t dbSNP:757397758
101 101 g, t dbSNP:781340266
102 102 c, t dbSNP:746304949
103 103 a, t dbSNP:770358380
110 110 c, g dbSNP:780242788
111 111 -, c dbSNP:759516856
116 116 c, t dbSNP:749703382
120 120 a, g, t dbSNP:369028901
126 126 a, g dbSNP:112927641
128 128 a, t dbSNP:760256128
142 142 c, t dbSNP:770496239
149 149 -, c dbSNP:769849723
149 149 a, g dbSNP:776216134
153 153 c, g dbSNP:759339073
155 155 a, g dbSNP:765247203
167 167 -, ct dbSNP:775706706
168 168 c, t dbSNP:752399380
170 170 c, t dbSNP:762799171
179 179 a, c, t dbSNP:764300457
180 180 a, g dbSNP:569385193
181 181 a, g dbSNP:781085099
183 183 a, c, g dbSNP:538164578
184 184 a, g dbSNP:185241633
186 186 a, c, t dbSNP:751848804
195 195 c, g dbSNP:568409555
198 198 c, t dbSNP:779423507
201 201 c, g dbSNP:371923151
208 208 a, g dbSNP:138743711
210 210 c, t dbSNP:746599697
215 215 a, g dbSNP:770636472
216 216 a, g dbSNP:775961020
217 217 c, t dbSNP:759121356
222 222 c, t dbSNP:769608700
225 225 c, t dbSNP:775568164
233 233 c, t dbSNP:762885584
236 236 c, t dbSNP:763821729
238 238 c, t dbSNP:751379639
244 244 a, g dbSNP:199592828
245 245 c, t dbSNP:761984325
246 246 g, t dbSNP:767822362
249 249 g, t dbSNP:572484796
255 255 -, a dbSNP:764476503
255 255 c, t dbSNP:553736996
256 256 a, g dbSNP:756275349
261 261 c, t dbSNP:201769089
263 263 a, c, t dbSNP:191131837
264 264 c, g dbSNP:779369515
266 266 c, t dbSNP:748551665
268 268 a, g dbSNP:149352594
272 272 c, t dbSNP:558477628
279 279 a, g dbSNP:745369773
284 284 g, t dbSNP:769284614
285 285 a, c, t dbSNP:143792250
287 287 a, t dbSNP:768613673
291 291 a, g dbSNP:774102429
294 294 c, t dbSNP:146191676
295 295 a, g dbSNP:767620801
298 298 c, t dbSNP:773550263
300 300 c, t dbSNP:760811531
301 301 c, t dbSNP:766422315
306 306 a, g dbSNP:753986633
309 309 g, t dbSNP:755498876
315 315 a, g dbSNP:143978911
324 324 c, t dbSNP:753085597
331 331 g, t dbSNP:370186182
333 333 c, t dbSNP:767737385
339 339 -, ag dbSNP:751893009
345 345 c, t dbSNP:374025158
348 348 c, t dbSNP:147307438
352 352 a, g dbSNP:755747436
354 354 c, t dbSNP:779500981
359 359 -, c dbSNP:762357074
360 360 c, g dbSNP:748838846
364 364 -, a dbSNP:767897318
366 366 c, t dbSNP:768558560
371 371 c, g dbSNP:774331157
374 374 c, t dbSNP:747890451
378 378 g, t dbSNP:771832548
386 386 c, g dbSNP:772893838
388 388 c, t dbSNP:760900720
390 390 c, t dbSNP:766735705
392 392 c, g dbSNP:776819133
395 395 a, t dbSNP:4331976
397 397 g, t dbSNP:377663923
398 398 a, g dbSNP:561213967
403 403 a, g dbSNP:574763920
404 404 a, g dbSNP:753192106
411 411 c, t dbSNP:763388326
412 412 a, g dbSNP:764473312
413 413 a, g dbSNP:751903027
416 416 a, g dbSNP:755761544
418 418 -, aaa dbSNP:753454928
419 419 c, g, t dbSNP:540248226
420 420 g, t dbSNP:753333100
423 423 -, g dbSNP:752419348
424 424 a, c, t dbSNP:369025359
425 425 -, at dbSNP:758083116
429 429 c, t dbSNP:748059770
431 431 a, g dbSNP:532246531

Target ORF information:

RefSeq Version NM_003523
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 1, H2be (HIST1H2BE), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003523

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGCCTGAGC CAGCGAAATC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCCGTGACC 
AAGGCGCAGA AGAAGGACGG CAAGAAGCGC AAGCGCAGCC GCAAGGAGAG CTACTCCGTA
TACGTGTACA AGGTGCTGAA ACAGGTCCAC CCCGACACCG GCATCTCCTC TAAAGCCATG
GGGATCATGA ATTCCTTTGT CAACGACATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC
CTGGCGCATT ACAACAAGCG CTCGACCATC ACCTCCAGGG AGATCCAGAC GGCCGTGCGC
CTGCTGCTTC CCGGGGAGCT GGCCAAGCAC GCTGTGTCAG AGGGCACCAA GGCCGTTACC
AAGTACACCA GCTCCAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.